rosacea

Summary

Summary: A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).

Top Publications

  1. Papageorgiou P, Clayton W, Norwood S, Chopra S, Rustin M. Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results. Br J Dermatol. 2008;159:628-32 pubmed publisher
    b>Rosacea is a common skin condition but the treatments currently available are not satisfactory. To assess the efficacy of intense pulsed light (IPL) for treatment of stage I rosacea (flushing, erythema and telangiectasia)...
  2. Elewski B, Draelos Z, Dreno B, Jansen T, Layton A, Picardo M. Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. J Eur Acad Dermatol Venereol. 2011;25:188-200 pubmed publisher
    ..of specific histological or serological markers, the gaps in understanding the aetiology and pathophysiology of rosacea, and the broad diversity in its clinical manifestations has made it difficult to reach international consensus on ..
  3. Vidigal M, Kakihara C, Gatti T, Tebcherani A, Pires M. Gnatophyma: a rare variant of phyma. Clin Exp Dermatol. 2008;33:743-4 pubmed publisher
    We report a case of a 44-year-old woman with an 8-year history of gnatophyma. Rosacea is a facial dermatosis that may present as flushing, erythema, telangiectases, papules, pustules and phyma...
  4. Yamasaki K, Kanada K, MacLeod D, Borkowski A, Morizane S, Nakatsuji T, et al. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol. 2011;131:688-97 pubmed publisher
    ..b>Rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli...
  5. Lacey N, Delaney S, Kavanagh K, Powell F. Mite-related bacterial antigens stimulate inflammatory cells in rosacea. Br J Dermatol. 2007;157:474-81 pubmed
    Patients with papulopustular rosacea have a higher density of Demodex folliculorum mites on their faces than normal subjects but the role, if any, of their mites in initiating inflammation is disputed...
  6. Li J, O Reilly N, Sheha H, Katz R, Raju V, Kavanagh K, et al. Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus proteins in patients with Facial rosacea. Ophthalmology. 2010;117:870-877.e1 pubmed publisher
    ..Facial rosacea, lid margin, and ocular surface inflammation were documented by photography and graded in a masked fashion...
  7. Ezra N, Greco J, Haley J, Chiu M. Gnatophyma and otophyma. J Cutan Med Surg. 2009;13:266-72 pubmed
    Phymas are slowly progressive, disfiguring disorders of the face and ears that represent the end stage of rosacea. The most common phyma is rhinophyma, yet similar swellings may occur on the chin (gnatophyma), forehead (metophyma), one ..
  8. Berardesca E, Cameli N, Cavallotti C, Levy J, Pierard G, de Paoli Ambrosi G. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008;7:8-14 pubmed publisher
    ..a topical treatment based on silymarin/methylsulfonilmethane (S-MSM) to improve erythematous-telangiectactic rosacea. Forty-six patients affected by stage I-III rosacea entered this double-blind, placebo-controlled study...
  9. Zhang J, Xu X, Rao N, Argyle B, McCoard L, Rusho W, et al. Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea. PLoS ONE. 2011;6:e16658 pubmed publisher
    b>Rosacea is a common disfiguring skin disease of primarily Caucasians characterized by central erythema of the face, with telangiectatic blood vessels, papules and pustules, and can produce skin thickening, especially on the nose of men, ..
  10. Yamasaki K, Gallo R. The molecular pathology of rosacea. J Dermatol Sci. 2009;55:77-81 pubmed publisher
    b>Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all related by the presence of chronic facial skin inflammation...

Detail Information

Publications62

  1. Papageorgiou P, Clayton W, Norwood S, Chopra S, Rustin M. Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results. Br J Dermatol. 2008;159:628-32 pubmed publisher
    b>Rosacea is a common skin condition but the treatments currently available are not satisfactory. To assess the efficacy of intense pulsed light (IPL) for treatment of stage I rosacea (flushing, erythema and telangiectasia)...
  2. Elewski B, Draelos Z, Dreno B, Jansen T, Layton A, Picardo M. Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. J Eur Acad Dermatol Venereol. 2011;25:188-200 pubmed publisher
    ..of specific histological or serological markers, the gaps in understanding the aetiology and pathophysiology of rosacea, and the broad diversity in its clinical manifestations has made it difficult to reach international consensus on ..
  3. Vidigal M, Kakihara C, Gatti T, Tebcherani A, Pires M. Gnatophyma: a rare variant of phyma. Clin Exp Dermatol. 2008;33:743-4 pubmed publisher
    We report a case of a 44-year-old woman with an 8-year history of gnatophyma. Rosacea is a facial dermatosis that may present as flushing, erythema, telangiectases, papules, pustules and phyma...
  4. Yamasaki K, Kanada K, MacLeod D, Borkowski A, Morizane S, Nakatsuji T, et al. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol. 2011;131:688-97 pubmed publisher
    ..b>Rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli...
  5. Lacey N, Delaney S, Kavanagh K, Powell F. Mite-related bacterial antigens stimulate inflammatory cells in rosacea. Br J Dermatol. 2007;157:474-81 pubmed
    Patients with papulopustular rosacea have a higher density of Demodex folliculorum mites on their faces than normal subjects but the role, if any, of their mites in initiating inflammation is disputed...
  6. Li J, O Reilly N, Sheha H, Katz R, Raju V, Kavanagh K, et al. Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus proteins in patients with Facial rosacea. Ophthalmology. 2010;117:870-877.e1 pubmed publisher
    ..Facial rosacea, lid margin, and ocular surface inflammation were documented by photography and graded in a masked fashion...
  7. Ezra N, Greco J, Haley J, Chiu M. Gnatophyma and otophyma. J Cutan Med Surg. 2009;13:266-72 pubmed
    Phymas are slowly progressive, disfiguring disorders of the face and ears that represent the end stage of rosacea. The most common phyma is rhinophyma, yet similar swellings may occur on the chin (gnatophyma), forehead (metophyma), one ..
  8. Berardesca E, Cameli N, Cavallotti C, Levy J, Pierard G, de Paoli Ambrosi G. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008;7:8-14 pubmed publisher
    ..a topical treatment based on silymarin/methylsulfonilmethane (S-MSM) to improve erythematous-telangiectactic rosacea. Forty-six patients affected by stage I-III rosacea entered this double-blind, placebo-controlled study...
  9. Zhang J, Xu X, Rao N, Argyle B, McCoard L, Rusho W, et al. Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea. PLoS ONE. 2011;6:e16658 pubmed publisher
    b>Rosacea is a common disfiguring skin disease of primarily Caucasians characterized by central erythema of the face, with telangiectatic blood vessels, papules and pustules, and can produce skin thickening, especially on the nose of men, ..
  10. Yamasaki K, Gallo R. The molecular pathology of rosacea. J Dermatol Sci. 2009;55:77-81 pubmed publisher
    b>Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all related by the presence of chronic facial skin inflammation...
  11. Kennedy Carney C, Cantrell W, Elewski B. Rosacea: a review of current topical, systemic and light-based therapies. G Ital Dermatol Venereol. 2009;144:673-88 pubmed
    b>Rosacea is a common chronic inflammatory disorder of the facial skin characterized by periods of exacerbation, remission and possible progression...
  12. Del Rosso J. The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. Cutis. 2006;77:22-4 pubmed
    Topical azelaic acid (AzA) is approved for the treatment of acne vulgaris and inflammatory (papulopustular) rosacea. Because of diverse mechanisms of action that correlate with potential therapeutic benefit, AzA has been used to treat ..
  13. Donaldson K, Karp C, Dunbar M. Evaluation and treatment of children with ocular rosacea. Cornea. 2007;26:42-6 pubmed
    To describe the clinical presentation and treatment of ocular rosacea in children, an often unrecognized entity...
  14. Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007;13:975-80 pubmed
    Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by erythema, papulopustules and telangiectasia...
  15. Wu J, Weinstein G, Kricorian G, Kormeili T, McCullough J. Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea. Clin Exp Dermatol. 2007;32:693-5 pubmed
    Many patients with rosacea are unable to tolerate extended treatment periods with topical agents because of the unusually high skin sensitivity that often accompanies rosacea...
  16. Sulk M, Seeliger S, Aubert J, Schwab V, Cevikbas F, Rivier M, et al. Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J Invest Dermatol. 2012;132:1253-62 pubmed publisher
    b>Rosacea is a frequent chronic inflammatory skin disease of unknown etiology. Because early rosacea reveals all characteristics of neurogenic inflammation, a central role of sensory nerves in its pathophysiology has been discussed...
  17. Carlson J, Mazza J, Kircher K, Tran T. Otophyma: a case report and review of the literature of lymphedema (elephantiasis) of the ear. Am J Dermatopathol. 2008;30:67-72 pubmed publisher
    Phymas (swellings, masses, or bulbs) are considered the end-stage of rosacea and mostly affect the nose (rhinophyma), and rarely involve the chin (gnatophyma), the cheek (metophyma), eyelids (blepharophyma), or ears (otophyma)...
  18. Lee J, Hsu C. Granulomatous rosacea-like demodicidosis. Dermatol Online J. 2007;13:9 pubmed
    Demodicidosis may present as pityriasis folliculitis, papulopustular lesions, rosacea-like eruptions, and granulomatous rosacea-like eruptions...
  19. Schechter B, Katz R, Friedman L. Efficacy of topical cyclosporine for the treatment of ocular rosacea. Adv Ther. 2009;26:651-9 pubmed publisher
    ..05% with an artificial tear solution for the treatment of rosacea-associated eyelid and corneal pathology...
  20. Yaylali V, Ozyurt C. Comparison of tear function tests and impression cytology with the ocular findings in acne rosacea. Eur J Ophthalmol. 2002;12:11-7 pubmed
    The aim of this study was to determine the correlation between tear function tests and impression cytology results and the clinical findings in ocular rosacea.
  21. Grønhøj Larsen F, Jakobsen P, Grønhøj Larsen C, Heidenheim M, Held E, Nielsen Kudsk F. The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol. Br J Dermatol. 2009;161:664-70 pubmed publisher
    Isotretinoin is effective in the treatment of severe acne and rosacea. Both parent drug and its main metabolite 4-oxo-isotretinoin are potentially teratogenic compounds and contain a carboxylic acid moiety...
  22. Korting H, Schöllmann C. Tetracycline actions relevant to rosacea treatment. Skin Pharmacol Physiol. 2009;22:287-94 pubmed publisher
    Until today, the pathogenesis of rosacea is not known in detail...
  23. Cetinkaya A, Akova Y. Pediatric ocular acne rosacea: long-term treatment with systemic antibiotics. Am J Ophthalmol. 2006;142:816-21 pubmed
    To report our experience with four cases of pediatric ocular acne rosacea, including responses to long-term systemic treatment. Retrospective interventional case series...
  24. Zhao Y, Wu L, Peng Y, Cheng H. Retrospective analysis of the association between Demodex infestation and rosacea. Arch Dermatol. 2010;146:896-902 pubmed publisher
    To explore the association between Demodex infestation and rosacea and the pathogenesis of demodicosis rosacea by means of a meta-analysis...
  25. Whitfeld M, Gunasingam N, Leow L, Shirato K, Preda V. Staphylococcus epidermidis: a possible role in the pustules of rosacea. J Am Acad Dermatol. 2011;64:49-52 pubmed publisher
    b>Rosacea is a common skin and ocular disease. Cutaneous rosacea is characterized by facial flushing, telangiectasia, papules, and pustules. It is generally regarded as inflammatory in nature...
  26. Moravvej H, Dehghan Mangabadi M, Abbasian M, Meshkat Razavi G. Association of rosacea with demodicosis. Arch Iran Med. 2007;10:199-203 pubmed
    There are controversial reports about the role of Demodex mites in pathogenesis of acne rosacea. The aim of this study was to examine the relationship between the presence and number of Demodex mites and the pathogenesis of rosacea...
  27. Jarmuda S, O Reilly N, Zaba R, Jakubowicz O, Szkaradkiewicz A, Kavanagh K. Potential role of Demodex mites and bacteria in the induction of rosacea. J Med Microbiol. 2012;61:1504-10 pubmed publisher
    b>Rosacea is a common dermatological condition that predominantly affects the central regions of the face. Rosacea affects up to 3?% of the world's population and a number of subtypes are recognized...
  28. Chamaillard M, Mortemousque B, Boralevi F, Marques da Costa C, Aitali F, Taieb A, et al. Cutaneous and ocular signs of childhood rosacea. Arch Dermatol. 2008;144:167-71 pubmed publisher
    Objectives To describe the clinical features of cutaneous and ocular manifestations of childhood rosacea, to propose diagnostic criteria, and to emphasize the possible severity of ocular complications in this age group.
  29. Fowler J. Combined effect of anti-inflammatory dose doxycycline (40-mg doxycycline, usp monohydrate controlled-release capsules) and metronidazole topical gel 1% in the treatment of rosacea. J Drugs Dermatol. 2007;6:641-5 pubmed
    Research into the pathophysiology of rosacea suggests a central role for inflammatory mediators such as nitric oxide (NO), reactive oxygen species (ROS), and matrix metalloproteinases (MMPs)...
  30. Shanler S, Ondo A. Successful treatment of the erythema and flushing of rosacea using a topically applied selective alpha1-adrenergic receptor agonist, oxymetazoline. Arch Dermatol. 2007;143:1369-71 pubmed
  31. Mini R, Figura N, D Ambrosio C, Braconi D, Bernardini G, Di Simplicio F, et al. Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria. Proteomics. 2005;5:777-87 pubmed
    b>Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms...
  32. Jansen T, Krug S, Kind P, Plewig G, Messer G. BsmI polymorphism of the vitamin D receptor gene in patients with the fulminant course of rosacea conglobata (rosacea fulminans). J Dermatol. 2004;31:244-6 pubmed
  33. Cuevas P, Arrazola J. Therapeutic response of rosacea to dobesilate. Eur J Med Res. 2005;10:454-6 pubmed
    Despite an incomplete understanding of the pathogenesis of rosacea, therapeutic modalities continue to expand...
  34. Lee W, Darlington J, Mannis M, Schwab I. Dendritic keratopathy in ocular rosacea. Cornea. 2005;24:632-3 pubmed
    To report a case of dendritic keratopathy secondary to ocular rosacea in a 62-year-old man. Case report...
  35. An H, Ninonuevo M, Aguilan J, Liu H, Lebrilla C, Alvarenga L, et al. Glycomics analyses of tear fluid for the diagnostic detection of ocular rosacea. J Proteome Res. 2005;4:1981-7 pubmed
    A Glycomics approach to detect disease is illustrated in the analyses of human tear fluid for rosacea. The diagnosis of ocular rosacea is particularly challenging in a subgroup of patients that do not present with typical facial skin ..
  36. Basta Juzbasic A, Subić J, Ljubojevic S. Demodex folliculorum in development of dermatitis rosaceiformis steroidica and rosacea-related diseases. Clin Dermatol. 2002;20:135-40 pubmed
  37. Powell F. Clinical practice. Rosacea. N Engl J Med. 2005;352:793-803 pubmed
  38. El Shazly A, Ghaneum B, Morsy T, Aaty H. The pathogenesis of Demodex folliculorum (hair follicular mites) in females with and without rosacea. J Egypt Soc Parasitol. 2001;31:867-75 pubmed
    In rosacea patients (ages 11-50 years old) 44% were infested with D. folliculorum as compared to normal controls (23.0%). The difference was significant. The mean +/-SD of mite density ranged between 13.2+/-0.9 to 18.2+/-1...
  39. Rohrich R, Griffin J, Adams W. Rhinophyma: review and update. Plast Reconstr Surg. 2002;110:860-69; quiz 870 pubmed
    ..The etiology and epidemiology of rhinophyma. 3. Associated diagnosis that can complicate rhinophyma. 4. Common nonsurgical and surgical therapies for rhinophyma. 5. A safe and integrated treatment plan for the patient with rhinophyma. ..
  40. Kari O, Aho V, Peltonen S, Saari J, Kari M, Määttä M, et al. Group IIA phospholipase A(2) concentration of tears in patients with ocular rosacea. Acta Ophthalmol Scand. 2005;83:483-6 pubmed
    To determine the concentration of group IIA phospholipase A(2) (GIIAPLA(2)) in tears of patients with ocular rosacea, and to compare it with GIIAPLA(2) concentration in tears of age-matched healthy controls...
  41. Jones D. Reactive oxygen species and rosacea. Cutis. 2004;74:17-20, 32-4 pubmed
    Although the fundamental pathogenesis of rosacea remains unknown, inflammation is a central process in this disorder...
  42. Bassichis B, Swamy R, Dayan S. Use of the KTP laser in the treatment of rosacea and solar lentigines. Facial Plast Surg. 2004;20:77-83 pubmed
    Numerous techniques have evolved in facial plastic surgery to treat rosacea and solar lentigines...
  43. Katoulis A, Georgala S, Stavrianeas N. Poikiloderma of civatte and rosacea: variants in the same nosological spectrum?. Dermatology. 2005;211:386-7 pubmed
  44. Draelos Z, Ertel K, Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis. 2005;76:135-41 pubmed
    ..The clinical signs and symptoms of rosacea, which include increased facial skin dryness and sensitivity, suggest a possible role for such moisturizers as an ..
  45. Mark K, Sparacio R, Voigt A, Marenus K, Sarnoff D. Objective and quantitative improvement of rosacea-associated erythema after intense pulsed light treatment. Dermatol Surg. 2003;29:600-4 pubmed
    ..In addition, very few studies specifically address rosacea-associated erythema...
  46. Kucukyilmaz I, Alpsoy E, Yazar S. Kaposi's varicelliform eruption in association with rosacea. J Am Acad Dermatol. 2004;51:S169-72 pubmed
    ..We report here a new case of Kaposi's varicelliform eruption in a 38-year-old woman with rosacea. To our knowledge, this is the first case of Kaposi's varicelliform eruption associated with rosacea to be ..
  47. Crawford G, Pelle M, James W. Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol. 2004;51:327-41; quiz 342-4 pubmed
    b>Rosacea is one of the most common conditions dermatologists treat. Rosacea is most often characterized by transient or persistent central facial erythema, visible blood vessels, and often papules and pustules...
  48. Forton F, Germaux M, Brasseur T, De Liever A, Laporte M, Mathys C, et al. Demodicosis and rosacea: epidemiology and significance in daily dermatologic practice. J Am Acad Dermatol. 2005;52:74-87 pubmed
    ..Demodicoses are thought to be rare, occurring mainly for patients with immunosuppression...
  49. Forton F, Seys B. Density of Demodex folliculorum in rosacea: a case-control study using standardized skin-surface biopsy. Br J Dermatol. 1993;128:650-9 pubmed
    A standardized skin-surface biopsy (1 cm2) of the check was performed in 49 patients with rosacea [13 with erythemato-telangiectatic rosacea (ETR), three with squamous rosacea (SR), 33 with papulopustular rosacea (PPR)], and 45 controls...