shock

Summary

Summary: A pathological condition manifested by failure to perfuse or oxygenate vital organs.

Top Publications

  1. Romero R, Kadar N, Vaisbuch E, Hassan S. Maternal death following cardiopulmonary collapse after delivery: amniotic fluid embolism or septic shock due to intrauterine infection?. Am J Reprod Immunol. 2010;64:113-25 pubmed publisher
    ..It may be possible to identify a subset of patients who have biochemical and immunological evidence of systemic inflammation at the time of admission, and before a catastrophic event occurs. ..
  2. De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, et al. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010;362:779-89 pubmed publisher
    Both dopamine and norepinephrine are recommended as first-line vasopressor agents in the treatment of shock. There is a continuing controversy about whether one agent is superior to the other...
  3. Paladino L, Subramanian R, Nabors S, Sinert R. The utility of shock index in differentiating major from minor injury. Eur J Emerg Med. 2011;18:94-8 pubmed publisher
    The importance of early recognition of hemorrhagic shock and its effects on outcome have long been recognized. Traditional vital signs are relatively insensitive as early diagnostic markers of hemorrhage...
  4. Bunnag T, Kalayanarooj S. Dengue shock syndrome at the emergency room of Queen Sirikit National Institute of Child Health, Bangkok, Thailand. J Med Assoc Thai. 2011;94 Suppl 3:S57-63 pubmed
    ..b>Shock is one of the common presentations at the emergency room (ER) and dengue shock syndrome (DSS) is among the common ..
  5. Probst C, Mirzayan M, Mommsen P, Zeckey C, Tegeder T, Geerken L, et al. Systemic inflammatory effects of traumatic brain injury, femur fracture, and shock: an experimental murine polytrauma model. Mediators Inflamm. 2012;2012:136020 pubmed publisher
    Despite broad research in neurotrauma and shock, little is known on systemic inflammatory effects of the clinically most relevant combined polytrauma...
  6. Samuelsson A, Farnebo S, Magnusson B, Anderson C, Tesselaar E, Zettersten E, et al. Implications for burn shock resuscitation of a new in vivo human vascular microdosing technique (microdialysis) for dermal administration of noradrenaline. Burns. 2012;38:975-83 pubmed publisher
    ..flow, and is therefore often used for recruitment of blood during states of hypoperfusion such as during burn shock resuscitation...
  7. Trof R, Beishuizen A, Cornet A, de Wit R, Girbes A, Groeneveld A. Volume-limited versus pressure-limited hemodynamic management in septic and nonseptic shock. Crit Care Med. 2012;40:1177-85 pubmed publisher
    To evaluate the effect of hemodynamic management guided by upper limits of cardiac filling volumes or pressures on durations of mechanical ventilation and lengths of stay in critically ill patients with shock.
  8. Johansson P, Sørensen A, Perner A, Welling K, Wanscher M, Larsen C, et al. High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. J Thromb Haemost. 2012;10:207-16 pubmed publisher
    ..Soluble CD40L is a platelet-derived mediator that links inflammation, hemostasis and vascular dysfunction...
  9. Polito A, Parisini E, Ricci Z, Picardo S, Annane D. Vasopressin for treatment of vasodilatory shock: an ESICM systematic review and meta-analysis. Intensive Care Med. 2012;38:9-19 pubmed publisher
    To examine the benefits and risks of vasopressin or its analog terlipressin for patients with vasodilatory shock.

More Information

Publications65

  1. Hicks C, Cui X, Sweeney D, Li Y, Barochia A, Eichacker P. The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shock. Toxins (Basel). 2011;3:1185-202 pubmed publisher
    ..One notable aspect of these cases has been the difficulty in supporting patients once shock has developed. Anthrax bacilli produce several different components which likely contribute to this shock...
  2. Cheung R, Shen F, Phillips J, McGeachy M, Cua D, Heyworth P, et al. Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J Clin Invest. 2011;121:4446-61 pubmed publisher
    Systemic inflammatory response syndrome (SIRS) is a potentially lethal condition, as it can progress to shock, multi-organ failure, and death. It can be triggered by infection, tissue damage, or hemorrhage...
  3. Chew M, Ihrman L, Düring J, Bergenzaun L, Ersson A, Undén J, et al. Extravascular lung water index improves the diagnostic accuracy of lung injury in patients with shock. Crit Care. 2012;16:R1 pubmed publisher
    ..Whether EVLW confers diagnostic value in a general population with shock, as well as which index performs best, is unclear...
  4. Linkermann A, Bräsen J, De Zen F, Weinlich R, Schwendener R, Green D, et al. Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-?-induced shock. Mol Med. 2012;18:577-86 pubmed publisher
    ..In the lethal mouse model of TNF?-mediated shock, addition of the pan-caspase inhibitor zVAD-fmk (zVAD) accelerates time to death...
  5. Urbano J, López Herce J, Solana M, del Castillo J, Botrán M, Bellón J. Comparison of normal saline, hypertonic saline and hypertonic saline colloid resuscitation fluids in an infant animal model of hypovolemic shock. Resuscitation. 2012;83:1159-65 pubmed publisher
    Incorrect resuscitation after hypovolemic shock is a major contributor to preventable pediatric death...
  6. Zeyed Y, Bastarache J, Matthay M, Ware L. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2012;303:L550-5 pubmed publisher
    ..Patients with ALI often develop circulatory shock, but how shock affects the rate of AFC is unknown...
  7. Kausar F, Morris J, Fathalla M, Ojengbede O, Fabamwo A, Mourad Youssif M, et al. Nurses in low resource settings save mothers' lives with non-pneumatic anti-shock garment. MCN Am J Matern Child Nurs. 2012;37:308-16 pubmed
    ..in preventing and treating postpartum hemorrhage (PPH) from uterine atony in developing countries and examine the role of a new device, the non-pneumatic anti-shock garment (NASG), in improving the outcomes for these patients.
  8. Guzman M, Alvarez M, Halstead S. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch Virol. 2013;158:1445-59 pubmed publisher
    ..virus (DENV) infection as a principal risk factor for severe dengue disease (dengue hemorrhagic fever/dengue shock syndrome, DHF/DSS)...
  9. Gupta A, Cooper Z, Tulapurkar M, Potla R, Maity T, Hasday J, et al. Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release. J Biol Chem. 2013;288:2756-66 pubmed publisher
    Heat shock protein (Hsp) 70 expression can be stimulated by febrile range temperature (FRT)...
  10. Ameloot K, Gillebert C, Desie N, Malbrain M. Hypoperfusion, shock states, and abdominal compartment syndrome (ACS). Surg Clin North Am. 2012;92:207-20, vii pubmed publisher
  11. Parsons E, Hough C, Seymour C, Cooke C, Rubenfeld G, Watkins T. Red blood cell transfusion and outcomes in patients with acute lung injury, sepsis and shock. Crit Care. 2011;15:R221 pubmed publisher
    In this study, we sought to determine the association between red blood cell (RBC) transfusion and outcomes in patients with acute lung injury (ALI), sepsis and shock.
  12. Chew M, Linder A, Santen S, Ersson A, Herwald H, Thorlacius H. Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study. Inflamm Res. 2012;61:375-9 pubmed publisher
    Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with shock.
  13. Mentzelopoulos S, Malachias S, Chamos C, Konstantopoulos D, Ntaidou T, Papastylianou A, et al. Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial. JAMA. 2013;310:270-9 pubmed publisher
    ..b>Shock after resuscitation was treated with stress-dose hydrocortisone (300 mg daily for 7 days maximum and gradual taper)..
  14. Barochia A, Cui X, Sun J, Li Y, Solomon S, Migone T, et al. Protective antigen antibody augments hemodynamic support in anthrax lethal toxin shock in canines. J Infect Dis. 2012;205:818-29 pubmed publisher
    Anthrax-associated shock is closely linked to lethal toxin (LT) release and is highly lethal despite conventional hemodynamic support...
  15. Chi C, Khanh T, Thoa L, Tseng F, Wang S, Thinh L, et al. Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial. Crit Care Med. 2013;41:1754-60 pubmed publisher
    Enterovirus 71-induced brainstem encephalitis with pulmonary edema and/or neurogenic shock (stage 3B) is associated with rapid mortality in children...
  16. Martin Loeches I, Deja M, Koulenti D, Dimopoulos G, Marsh B, Torres A, et al. Potentially resistant microorganisms in intubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors. Intensive Care Med. 2013;39:672-81 pubmed publisher
  17. Aksu U, Bezemer R, Demirci C, Ince C. Acute effects of balanced versus unbalanced colloid resuscitation on renal macrocirculatory and microcirculatory perfusion during endotoxemic shock. Shock. 2012;37:205-9 pubmed publisher
    ..on renal macrocirculatory and microcirculatory perfusions during lipopolysaccharide-induced endotoxemic shock in rats...
  18. Annane D, Siami S, Jaber S, Martin C, Elatrous S, Declère A, et al. Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA. 2013;310:1809-17 pubmed publisher
    Evidence supporting the choice of intravenous colloid vs crystalloid solutions for management of hypovolemic shock remains unclear.
  19. Krakauer T, Buckley M. Intranasal rapamycin rescues mice from staphylococcal enterotoxin B-induced shock. Toxins (Basel). 2012;4:718-28 pubmed publisher
    ..and related exotoxins produced by Staphylococcus aureus are potent activators of the immune system and cause toxic shock in humans...
  20. Mutschler M, Nienaber U, Brockamp T, Wafaisade A, Wyen H, Peiniger S, et al. A critical reappraisal of the ATLS classification of hypovolaemic shock: does it really reflect clinical reality?. Resuscitation. 2013;84:309-13 pubmed publisher
    The aim of this study was to validate the classification of hypovolaemic shock given by the Advanced Trauma Life Support (ATLS).
  21. Visser M, Vermeulen M, Richir M, Teerlink T, Houdijk A, Kostense P, et al. Imbalance of arginine and asymmetric dimethylarginine is associated with markers of circulatory failure, organ failure and mortality in shock patients. Br J Nutr. 2012;107:1458-65 pubmed publisher
    In shock, organ perfusion is of vital importance because organ oxygenation is at risk. NO, the main endothelial-derived vasodilator, is crucial for organ perfusion and coronary patency...
  22. van Genderen M, Klijn E, Lima A, de Jonge J, Sleeswijk Visser S, Voorbeijtel J, et al. Microvascular perfusion as a target for fluid resuscitation in experimental circulatory shock. Crit Care Med. 2014;42:e96-e105 pubmed publisher
    To study regional perfusion during experimental endotoxemic and obstructive shock and compare the effect of initial cardiac output-targeted fluid resuscitation with optimal cardiac output-targeted resuscitation on different peripheral ..
  23. Hu S, Hou J, Wang H, Yang M, Sheng Z. The effect of valproic acid in alleviating early death in burn shock. Burns. 2012;38:83-9 pubmed publisher
    ..to examine whether administration of valproic acid (VPA) improves blood circulation and survival after lethal burn shock. Forty adult male Beagle dogs underwent a 50% TBSA full-thickness flame injury...
  24. Hoffmann U, Borggrefe M, Brueckmann M. New horizons: NT-proBNP for risk stratification of patients with shock in the intensive care unit. Crit Care. 2006;10:134 pubmed
    ..and prognostic use of natriuretic peptides in the intensive care setting for patients with various forms of shock could be an attractive alternative as noninvasive markers of cardiac dysfunction that could obviate the need for ..
  25. Dugo L, Collin M, Thiemermann C. Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation. Shock. 2007;27:113-23 pubmed
    ..to the regulation of glycogen synthase activity, has recently been clinically used in the therapy for septic shock. The beneficial anti-inflammatory effects of insulin in preclinical and clinical studies could possibly be due, at ..
  26. Badami C, Senthil M, Caputo F, Rupani B, Doucet D, Pisarenko V, et al. Mesenteric lymph duct ligation improves survival in a lethal shock model. Shock. 2008;30:680-5 pubmed publisher
    ..To test this hypothesis, a lethal splanchnic artery occlusion (SAO) shock model was used in male Sprague-Dawley rats...
  27. Elbers P, Ince C. Mechanisms of critical illness--classifying microcirculatory flow abnormalities in distributive shock. Crit Care. 2006;10:221 pubmed
    Over 30 years ago Weil and Shubin proposed a re-classification of shock states and identified hypovolemic, cardiogenic, obstructive and distributive shock...
  28. Michell M, Oliveira H, Kinsky M, Vaid S, Herndon D, Kramer G. Enteral resuscitation of burn shock using World Health Organization oral rehydration solution: a potential solution for mass casualty care. J Burn Care Res. 2006;27:819-25 pubmed
    Enteral resuscitation could provide a means to resuscitate burn shock when intravenous (IV) therapy is unavailable, such as in mass disasters...
  29. Wafaisade A, Wutzler S, Lefering R, Tjardes T, Banerjee M, Paffrath T, et al. Drivers of acute coagulopathy after severe trauma: a multivariate analysis of 1987 patients. Emerg Med J. 2010;27:934-9 pubmed publisher
    ..This study was conducted to assess the risk factors associated with acute traumatic coagulopathy together with quantitative estimates of their importance...
  30. Krausz L, Bianchini R, Ronchetti S, Fettucciari K, Nocentini G, Riccardi C. GITR-GITRL system, a novel player in shock and inflammation. ScientificWorldJournal. 2007;7:533-66 pubmed
    ..evidence suggests that the GITR/GITRL system participates in the development of inflammatory responses, including shock, either due to early response of neutrophils and macrophages, or together with autoimmune/allergic pathogenesis...
  31. Luckner G, Mayr V, Jochberger S, Wenzel V, Ulmer H, Hasibeder W, et al. Comparison of two dose regimens of arginine vasopressin in advanced vasodilatory shock. Crit Care Med. 2007;35:2280-5 pubmed
    ..To evaluate the effects of two arginine vasopressin (AVP) dose regimens (0.033 vs. 0.067 IU/min) on treatment efficacy, hemodynamic response, prevalence of adverse events, and changes in laboratory variables...
  32. Scarcello E, Ferrari M, Rossi G, Berchiolli R, Adami D, Romagnani F, et al. A new preoperative predictor of outcome in ruptured abdominal aortic aneurysms: the time before shock (TBS). Ann Vasc Surg. 2010;24:315-20 pubmed publisher
    In patients with ruptured abdominal aortic aneurysm (RAAA) and shock, the time lag between the onset of the symptoms due to RAAA and the presence of a full developed shock syndrome was evaluated to assess its prognostic meaning...
  33. Esposito E, Cuzzocrea S. Superoxide, NO, peroxynitrite and PARP in circulatory shock and inflammation. Front Biosci (Landmark Ed). 2009;14:263-96 pubmed
    ..and high energy oxidants (such as peroxynitrite) as mediators of tissue injury associated with circulatory shock and inflammation. Reactive oxygen species (ROS) (e.g...
  34. van der Heijden M, Verheij J, van Nieuw Amerongen G, Groeneveld A. Crystalloid or colloid fluid loading and pulmonary permeability, edema, and injury in septic and nonseptic critically ill patients with hypovolemia. Crit Care Med. 2009;37:1275-81 pubmed publisher
    ..We hypothesized that 1) crystalloid loading results in more edema formation than colloid loading and 2) the differences among the types of fluid decreases at high permeability...
  35. Choong K, Kissoon N. Vasopressin in pediatric shock and cardiac arrest. Pediatr Crit Care Med. 2008;9:372-9 pubmed publisher
    To review the physiology and the published literature on the role of vasopressin in shock in children.
  36. Dunser M, Westphal M. Arginine vasopressin in vasodilatory shock: effects on metabolism and beyond. Curr Opin Anaesthesiol. 2008;21:122-7 pubmed publisher
    To describe the effects of arginine vasopressin other than its vasoconstrictive and antidiuretic potential in vasodilatory shock.
  37. McMahon C, Kenny R, Bennett K, Little R, Kirkman E. The effect of acute traumatic brain injury on the performance of shock index. J Trauma. 2010;69:1169-75 pubmed publisher
    b>Shock index (SI) is recognized to be a more reliable early indicator of hemorrhage than traditional vital signs...
  38. Monge García M, Gil Cano A, Gracia Romero M. Dynamic arterial elastance to predict arterial pressure response to volume loading in preload-dependent patients. Crit Care. 2011;15:R15 pubmed publisher
  39. Januzzi J, Morss A, Tung R, Pino R, Fifer M, Thompson B, et al. Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study. Crit Care. 2006;10:R37 pubmed
    Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in evaluating heart failure, but its role in evaluating patients with shock in the intensive care unit (ICU) is not clear.
  40. O Dwyer M, Mankan A, Stordeur P, O Connell B, Duggan E, White M, et al. The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression. Shock. 2006;26:544-50 pubmed
    ..These groups consisted of an intensive care unit (ICU) cohort who presented with severe sepsis or septic shock, a group of noncritically ill ward patients with documented Gram-negative bacteremia, and a group of healthy ..
  41. Penn A, Schmid Schonbein G. The intestine as source of cytotoxic mediators in shock: free fatty acids and degradation of lipid-binding proteins. Am J Physiol Heart Circ Physiol. 2008;294:H1779-92 pubmed publisher
    b>Shock and multiple organ failure remain primary causes of late-stage morbidity and mortality in victims of trauma...
  42. Ivanovska N, Dimitrova P, Luckett J, El Rachkidy Lonnen R, Schwaeble W, Stover C. Properdin deficiency in murine models of nonseptic shock. J Immunol. 2008;180:6962-9 pubmed
    ..Its relative contribution toward the outcome of nonseptic shock has not been investigated...
  43. Goldman D, Casadevall A. Anthrax-associated shock. Front Biosci. 2008;13:4009-14 pubmed
    Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy...
  44. Hu S, Che J, Tian Y. [Effect of oral fluid resuscitation on pulmonary vascular permeability and lung water content in burn dogs in shock stage]. Zhonghua Shao Shang Za Zhi. 2009;25:184-7 pubmed
    To investigate the effect of oral fluid resuscitation on pulmonary vascular permeability and lung water content in burn dogs during shock stage.
  45. Xuan B, Mai H, Thi T, Thi M, Nguyen H, Rabenou R. Swarming hornet attacks: shock and acute kidney injury--a large case series from Vietnam. Nephrol Dial Transplant. 2010;25:1146-50 pubmed publisher
    ..Social hornets attack victims in swarms in Asia, Africa and the Middle East. The venom consists of multiple proteins with myotoxin, haemotoxin, vasodilatory and anticoagulant effects...
  46. Perera P, Mailhot T, Riley D, Mandavia D. The RUSH exam: Rapid Ultrasound in SHock in the evaluation of the critically lll. Emerg Med Clin North Am. 2010;28:29-56, vii pubmed publisher
    The RUSH exam (Rapid Ultrasound in SHock examination), presented in this article, represents a comprehensive algorithm for the integration of bedside ultrasound into the care of the patient in shock...
  47. Zhang Q, Itagaki K, Hauser C. Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase. Shock. 2010;34:55-9 pubmed publisher
    ..Thus, mtDNA retains molecular motifs similar to bDNA. It is unknown, however, whether mtDNA is released by shock or is capable of eliciting immune responses like bDNA...
  48. Shafi S, Elliott A, Gentilello L. Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma. 2005;59:1081-5 pubmed
    ..We tested the hypothesis that HT is associated with improved survival in trauma patients by analyzing a large, national trauma database...
  49. Greer R. The temporal evolution of acute respiratory distress syndrome following shock. Eur J Anaesthesiol. 2010;27:226-32 pubmed publisher
    ..The underlying pathophysiological mechanisms include activation of the immune response, neutrophil activation and sequestration of these into the alveolus with subsequent tissue damage and hypoxia...
  50. Shalhub S, Junker C, Imahara S, Mindrinos M, Dissanaike S, O Keefe G. Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study. J Trauma. 2009;66:115-22; discussion 122-3 pubmed publisher
    ..Genetic variation contributes to risk and outcomes of sepsis. We sought to determine whether variation in inflammation related genes is associated with severity of sepsis in trauma patients...
  51. Ah Soune P, Vitton V, Subtil C, Meunier Carpentier S, Bonmardion R, Desjeux A, et al. [Ectopic pancreas: an exceptional cause of lower intestinal bleeding with hemorrhagic shock]. Gastroenterol Clin Biol. 2008;32:202-4 pubmed publisher
  52. Toosi M, Merlino J, Leeper K. Prognostic value of the shock index along with transthoracic echocardiography in risk stratification of patients with acute pulmonary embolism. Am J Cardiol. 2008;101:700-5 pubmed publisher
    ..To assess the value of shock index and echocardiographic abnormalities as predictors of in-hospital complications and mortality, ..
  53. Barrington K. Hypotension and shock in the preterm infant. Semin Fetal Neonatal Med. 2008;13:16-23 pubmed
    ..the unique characteristics of the neonatal cardiovascular system, and addresses the definitions of hypotension and shock in the preterm infant, the indications for treatment and appropriate therapies in individual cases...
  54. Cui X, Li Y, Li X, Laird M, Subramanian M, Moayeri M, et al. Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model. J Infect Dis. 2007;195:572-80 pubmed
    To better define the contribution of edema toxins (ETx) and lethal toxins (LeTx) to shock with Bacillus anthracis, recombinant preparations of each were investigated alone or together in rats.
  55. Jang D, Nelson L, Hoffman R. Methylene blue in the treatment of refractory shock from an amlodipine overdose. Ann Emerg Med. 2011;58:565-7 pubmed publisher
    ..Methylene blue also has the ability to scavenge nitric oxide, as well as inhibit nitric oxide synthase. We report the use of methylene blue for refractory shock in a patient with amlodipine toxicity.
  56. Sakr Y, Reinhart K, Vincent J, Sprung C, Moreno R, Ranieri V, et al. Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med. 2006;34:589-97 pubmed
    The optimal adrenergic support in shock is controversial. We investigated whether dopamine administration influences the outcome from shock.