Summary: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Top Publications

  1. Gordon M, El Kalla M, Zhao Y, Fiteih Y, Law J, Volodko N, et al. The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS ONE. 2013;8:e75483 pubmed publisher
    ..Here we report that RASSF1A is a novel regulator of intestinal inflammation as Rassf1a(+/-) , Rassf1a(-/-) and an intestinal epithelial cell specific knockout mouse (Rassf1a (IEC-KO) ) ..
  2. Saunders C, Christensen M, Finger T, Tizzano M. Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation. Proc Natl Acad Sci U S A. 2014;111:6075-80 pubmed publisher
    ..Direct chemical excitation of trigeminal pain fibers by capsaicin evokes neurogenic inflammation in the surrounding epithelium...
  3. Rong X, Albert C, Hong C, Duerr M, Chamberlain B, Tarling E, et al. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013;18:685-97 pubmed publisher
    ..Conversely, Lpcat3 knockdown in liver exacerbates ER stress and inflammation. Mechanistically, Lpcat3 modulates inflammation both by regulating inflammatory kinase activation through ..
  4. Weckbach L, Gola A, Winkelmann M, Jakob S, Groesser L, Borgolte J, et al. The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via ?2 integrins (CD11/CD18). Blood. 2014;123:1887-96 pubmed publisher
    Emerging evidence suggests a role of the cytokine midkine (MK) in inflammation. In this study, its functional relevance for recruitment of polymorphonuclear neutrophils (PMNs) during acute inflammation was investigated...
  5. Riol Blanco L, Ordovas Montanes J, Perro M, Naval E, Thiriot A, Alvarez D, et al. Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature. 2014;510:157-61 pubmed publisher
    ..T (γδT17) cells, the aberrant activation of which by IL-23 can provoke psoriasis-like inflammation. The skin is also innervated by a meshwork of peripheral nerves consisting of relatively sparse autonomic and ..
  6. Montecucco F, Cea M, Cagnetta A, Damonte P, Nahimana A, Ballestrero A, et al. Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders. Curr Top Med Chem. 2013;13:2930-8 pubmed
    ..Overall, NAMPT inhibition holds potential for the treatment of inflammation-related disorders and the development of effective and safe NAMPT inhibitors remains an area of strong interest ..
  7. Belkaid Y, Hand T. Role of the microbiota in immunity and inflammation. Cell. 2014;157:121-41 pubmed publisher
    ..This phenomenon is proposed to account for some of the dramatic rise in autoimmune and inflammatory disorders in parts of the world where our symbiotic relationship with the microbiota has been the most affected. ..
  8. Buckley C, Gilroy D, Serhan C. Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity. 2014;40:315-27 pubmed publisher
    ..Indeed, the resolution phase of inflammation is just as actively orchestrated and carefully choreographed as its induction and inhibition...
  9. Mira Y, Muhuyati -, Lu W, He P, Liu Z, Yang Y. TGF-β1 signal pathway in the regulation of inflammation in patients with atrial fibrillation. Asian Pac J Trop Med. 2013;6:999-1003 pubmed publisher
    ..547). There were also a positive correlation between Smad3 and IL-6 mRNA (r=0.823). AF is associated with inflammation, and the inflammation is also involved in the fibrillation and sustain of AF...

More Information

Publications111 found, 100 shown here

  1. Samad F, Ruf W. Inflammation, obesity, and thrombosis. Blood. 2013;122:3415-22 pubmed publisher
    ..disorders, including obesity, insulin resistance, type 2 diabetes, and hepatic steatosis, involve inflammation elicited by infiltration and activation of immune cells, particularly macrophages, into adipose tissue...
  2. Jimenez Gomez Y, Mattison J, Pearson K, Martin Montalvo A, Palacios H, Sossong A, et al. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab. 2013;18:533-45 pubmed publisher
    Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes...
  3. Modvig S, Degn M, Horwitz H, Cramer S, Larsson H, Wanscher B, et al. Relationship between cerebrospinal fluid biomarkers for inflammation, demyelination and neurodegeneration in acute optic neuritis. PLoS ONE. 2013;8:e77163 pubmed publisher
    ..To investigate the interrelation between biomarkers of inflammation, demyelination and neurodegeneration in acute optic neuritis and to assess their association to measures of MS ..
  4. McCarthy C, Goulopoulou S, Wenceslau C, Spitler K, Matsumoto T, Webb R. Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension. Am J Physiol Heart Circ Physiol. 2014;306:H184-96 pubmed publisher
    Low-grade systemic inflammation is a common manifestation of hypertension; however, the exact mechanisms that initiate this pathophysiological response, thereby contributing to further increases in blood pressure, are not well understood...
  5. Wang B, Sun J, Li X, Zhou Q, Bai J, Shi Y, et al. Resveratrol prevents suppression of regulatory T-cell production, oxidative stress, and inflammation of mice prone or resistant to high-fat diet-induced obesity. Nutr Res. 2013;33:971-81 pubmed publisher
    Consumption of a high-fat diet (HFD) is correlated with increased oxidative stress and chronic inflammation in many organs. Regulatory T cells (Tregs) are essential negative regulators of inflammation...
  6. Leonard B. Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry. 2014;48:261-7 pubmed publisher
    This review summarises the evidence that chronic low grade inflammation plays an important role in the pathology of depression...
  7. Sandler N, Sereti I. Can early therapy reduce inflammation?. Curr Opin HIV AIDS. 2014;9:72-9 pubmed publisher
    ..outnumber AIDS events in the current combination antiretroviral therapy (ART) era and are attributed to chronic inflammation. Thus, a better understanding of why inflammation persists on ART will assist in developing better therapeutic ..
  8. Lade A, Noon L, Friedman S. Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer. Curr Opin Oncol. 2014;26:100-7 pubmed publisher that could culminate in cancer, as well as the emerging contribution of the gut-liver axis in promoting inflammation, senescence, and tumor growth in NASH and HCC...
  9. Bergink V, Gibney S, Drexhage H. Autoimmunity, inflammation, and psychosis: a search for peripheral markers. Biol Psychiatry. 2014;75:324-31 pubmed publisher
    ..Further, animal models of psychotic conditions (maternal stress and inflammation paradigms) suggest that such monocyte/microglia activation could be seen as the result of a combination of ..
  10. Kim Y, Udayanga K, Totsuka N, Weinberg J, Nunez G, Shibuya A. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE?. Cell Host Microbe. 2014;15:95-102 pubmed publisher
    ..We report that gut dysbiosis induced by antibiotic (Abx) treatment promotes allergic airway inflammation by shifting macrophage polarization in the lung toward the alternatively activated M2 phenotype...
  11. Brogden K, Johnson G, Vincent S, Abbasi T, Vali S. Oral inflammation, a role for antimicrobial peptide modulation of cytokine and chemokine responses. Expert Rev Anti Infect Ther. 2013;11:1097-113 pubmed publisher
    Acute and chronic inflammation commonly occurs throughout the oral cavity. The most common causes are physical damage and microbial infections, and less frequently immune reactions and malignant changes...
  12. Demoruelle M, Deane K, Holers V. When and where does inflammation begin in rheumatoid arthritis?. Curr Opin Rheumatol. 2014;26:64-71 pubmed publisher
    ..An improved understanding of the initial steps in the development of RA would provide insights into disease pathogenesis that could ultimately lead to more effective treatments and/or novel preventive strategies in RA...
  13. Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, et al. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. Cell Metab. 2013;18:491-504 pubmed publisher
    ..Here we describe a previously unknown role of class 3 semaphorin E (Sema3E) in adipose tissue inflammation and insulin resistance...
  14. Schiffrin E. Immune mechanisms in hypertension and vascular injury. Clin Sci (Lond). 2014;126:267-74 pubmed publisher
    Over the last 20 years it has become recognized that low-grade inflammation plays a role in cardiovascular disease...
  15. Zhao H, Anand A, Ganju R. Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia. J Immunol. 2014;192:385-93 pubmed publisher
    ..Further studies reveal that LPS enhances endothelial inflammation by downregulating the anti-inflammatory Slit2 and Robo4 in HUVECs in vitro, as well as in arterial endothelial ..
  16. Etzerodt A, Rasmussen M, Svendsen P, Chalaris A, Schwarz J, Galea I, et al. Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-? in macrophages. J Biol Chem. 2014;289:778-88 pubmed publisher
    ..receptor CD163 and proTNF-? are transmembrane macrophage proteins subjected to cleavage by the inflammation-responsive protease ADAM17. This leads to release of soluble CD163 (sCD163) and bioactive TNF-?...
  17. Ley S, Sun Q, Willett W, Eliassen A, Wu K, Pan A, et al. Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. Am J Clin Nutr. 2014;99:352-60 pubmed publisher
    ..However, the relation of red meat intake to biomarkers of inflammation and glucose metabolism has not been investigated thoroughly...
  18. Ren Y, Young W. Managing inflammation after spinal cord injury through manipulation of macrophage function. Neural Plast. 2013;2013:945034 pubmed publisher
    Spinal cord injury (SCI) triggers inflammation with activation of innate immune responses that contribute to secondary injury including oligodendrocyte apoptosis, demyelination, axonal degeneration, and neuronal death...
  19. Amor S, Peferoen L, Vogel D, Breur M, van der Valk P, Baker D, et al. Inflammation in neurodegenerative diseases--an update. Immunology. 2014;142:151-66 pubmed publisher neurodegenerative diseases contributing to tissue damage, but also plays important roles in resolving inflammation and mediating neuroprotection and repair...
  20. Philpott D, Sorbara M, Robertson S, Croitoru K, Girardin S. NOD proteins: regulators of inflammation in health and disease. Nat Rev Immunol. 2014;14:9-23 pubmed publisher
  21. Mori J, Patel V, Abo Alrob O, Basu R, Altamimi T, Desaulniers J, et al. Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation. Circ Heart Fail. 2014;7:327-39 pubmed publisher Ang 1-7 was accompanied by a reduction in myocardial lipid accumulation and systemic fat mass and inflammation and increased insulin-stimulated myocardial glucose oxidation...
  22. Das A, Ganesh K, Khanna S, Sen C, Roy S. Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation. J Immunol. 2014;192:1120-9 pubmed publisher
    ..of apoptotic cells by wound macrophages or efferocytosis is a prerequisite for the timely resolution of inflammation. Emerging evidence indicates that microRNA-21 (miR-21) may regulate the inflammatory response...
  23. Zhang C, Kong X, Liu C, Liang Z, Zhao H, Tong W, et al. ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats. Biochem Biophys Res Commun. 2014;444:395-400 pubmed publisher
    ..None of the rats expired and no obvious adverse effects were observed. Local delivery of a lentiviral siRNA targeting ERK2 can prevent epidural scar adhesion in post-laminectomy rat via inhibiting collagen expression and inflammation.
  24. Wong W, Vince J, Lalaoui N, Lawlor K, Chau D, Bankovacki A, et al. cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014;123:2562-72 pubmed publisher
    ..lineage caused overproduction of many proinflammatory cytokines, resulting in granulocytosis and severe sterile inflammation. In vitro differentiation of macrophages from bone marrow in the absence of cIAPs and XIAP led to detectable ..
  25. Ryan A, Ge S, Blumenthal J, Serra M, Prior S, Goldberg A. Aerobic exercise and weight loss reduce vascular markers of inflammation and improve insulin sensitivity in obese women. J Am Geriatr Soc. 2014;62:607-14 pubmed publisher
    To examine the relationships between plasma and tissue markers of systemic and vascular inflammation and obesity and insulin resistance and determine the effects of aerobic exercise training plus weight loss (AEX+WL) and weight loss (WL) ..
  26. Zeng W, Guo Y, Qi W, Chen J, Yang L, Luo Z, et al. 4-Phenylbutyric acid suppresses inflammation through regulation of endoplasmic reticulum stress of endothelial cells stimulated by uremic serum. Life Sci. 2014;103:15-24 pubmed publisher
    ..These findings suggest that regulation of ER stress coupled with inflammatory activation by 4-PBA would be a promising therapy to reverse the process and development of uremic serum-induced EC dysfunction. ..
  27. van de Stadt L, de Vrieze H, Derksen N, Brouwer M, Wouters D, van Schaardenburg D, et al. Antibodies to IgG4 hinge can be found in rheumatoid arthritis patients during all stages of disease and may exacerbate chronic antibody-mediated inflammation. Arthritis Rheumatol. 2014;66:1133-40 pubmed publisher
    ..protein antibodies (ACPAs) develop in response to neoepitopes that are formed under conditions of chronic inflammation. These autoantibodies may subsequently be fragmented by inflammation-associated proteases, leading to the ..
  28. de Araújo Júnior R, Souza T, de Moura L, Torres K, de Souza L, Alves M, et al. Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis. PLoS ONE. 2013;8:e75322 pubmed publisher
    ..The findings support a role of Atorvastatin for reducing the bone loss, inflammatory response, oxidative stress, and expression of extracellular matrix proteins, while reducing RANK/RANKL and increase OPG in periodontal disease. ..
  29. Tang C, Huang H, Lee Y, Tang Y, Wang C. Hepatoprotective effect of mulberry water extracts on ethanol-induced liver injury via anti-inflammation and inhibition of lipogenesis in C57BL/6J mice. Food Chem Toxicol. 2013;62:786-96 pubmed publisher
    ..This may be mediated by multiple pathways, including reduced lipid accumulation and lipid synthesis, increased fatty acid transport and fatty acid oxidation responses, decreased oxidative stress and facilitated anti-inflammation.
  30. Berk M, Williams L, Jacka F, O Neil A, Pasco J, Moylan S, et al. So depression is an inflammatory disease, but where does the inflammation come from?. BMC Med. 2013;11:200 pubmed publisher
    ..The obvious question this poses is 'what is the source of this chronic low-grade inflammation?' This review explores the role of inflammation and oxidative and nitrosative stress as possible mediators of ..
  31. Zanetti M, Harris S, Dawson Hughes B. Ability of vitamin D to reduce inflammation in adults without acute illness. Nutr Rev. 2014;72:95-8 pubmed publisher
    In vitro studies and some clinical studies suggest that vitamin D plays an important role in reducing inflammation. The objective of this review was to examine recent evidence that vitamin D status influences the level of inflammation in ..
  32. Son D, Kumar S, Takabe W, Kim C, Ni C, Alberts Grill N, et al. The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nat Commun. 2013;4:3000 pubmed publisher
    ..MMPs) and a disintegrin and metalloproteases (ADAMs) and stimulate pro-atherogenic responses, endothelial inflammation and permeability...
  33. Kurashima Y, Goto Y, Kiyono H. Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur J Immunol. 2013;43:3108-15 pubmed publisher
    ..Disruption of mucosal homeostasis causes intestinal inflammation such as that seen in inflammatory bowel disease...
  34. Kichev A, Rousset C, Baburamani A, Levison S, Wood T, Gressens P, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation. J Biol Chem. 2014;289:9430-9 pubmed publisher
    ..The toxicity of TRAIL in primary neurons suggests that TRAIL signaling participates in neonatal brain injury after inflammation and HI.
  35. Dammann K, Khare V, Gasche C. Tracing PAKs from GI inflammation to cancer. Gut. 2014;63:1173-84 pubmed publisher
    ..Intestinal PAK1 expression increases with inflammation and malignant transformation, although the biological relevance of PAKs in the development and progression of ..
  36. Patki G, Solanki N, Atrooz F, Allam F, Salim S. Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. Brain Res. 2013;1539:73-86 pubmed publisher
  37. Jakobsdottir G, Xu J, Molin G, Ahrne S, Nyman M. High-fat diet reduces the formation of butyrate, but increases succinate, inflammation, liver fat and cholesterol in rats, while dietary fibre counteracts these effects. PLoS ONE. 2013;8:e80476 pubmed publisher
    ..These effects may be associated with short-chain fatty acids (SCFAs), particularly propionic and butyric acids, formed by microbial degradation of dietary fibres in colon, and by their capacity to reduce low-grade inflammation.
  38. Neyrinck A, Alligier M, Memvanga P, Névraumont E, Larondelle Y, Préat V, et al. Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue. PLoS ONE. 2013;8:e81252 pubmed publisher
    ..doses of curcumin, derived from the spice Curcuma longa, have been proposed as a potential treatment of inflammation and metabolic disorders related to obesity...
  39. Murinello S, Mullins R, Lotery A, Perry V, Teeling J. Fc? receptor upregulation is associated with immune complex inflammation in the mouse retina and early age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;55:247-58 pubmed publisher
    Several lines of evidence suggest the involvement of antibodies and immune complex inflammation in AMD, a blinding disease with a strong inflammatory component...
  40. Brehm A, Geraghty P, Campos M, Garcia Arcos I, Dabo A, Gaffney A, et al. Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation. FASEB J. 2014;28:2318-31 pubmed publisher
    ..chronic obstructive pulmonary disease (COPD), this study aimed to determine how PLTP affects lung signaling and inflammation. Despite its increased expression, PLTP activity decreased by 80% in COPD bronchoalveolar lavage fluid (BALF) ..
  41. Holmdahl R, Malmstrom V, Burkhardt H. Autoimmune priming, tissue attack and chronic inflammation - the three stages of rheumatoid arthritis. Eur J Immunol. 2014;44:1593-9 pubmed publisher
    ..This inflammatory reaction might be clinically diagnosed as the earliest signs of the disease. Third, inflammation is converted to a chronic process leading to tissue destruction and remodeling...
  42. Libby P, Tabas I, Fredman G, Fisher E. Inflammation and its resolution as determinants of acute coronary syndromes. Circ Res. 2014;114:1867-79 pubmed publisher
    b>Inflammation contributes to many of the characteristics of plaques implicated in the pathogenesis of acute coronary syndromes...
  43. Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, et al. TRPA1: a transducer and amplifier of pain and inflammation. Basic Clin Pharmacol Toxicol. 2014;114:50-5 pubmed publisher induced and amplified by TRPA1 not only elicits pain sensation but also contributes to peripheral neurogenic inflammation through a peripheral axon reflex or a centrally mediated back propagating dorsal root reflex that releases ..
  44. Csóka B, Koscsó B, Töro G, Kókai E, Virag L, Németh Z, et al. A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation. Diabetes. 2014;63:850-66 pubmed publisher
    ..ARs) are important regulators of macrophage activation, we examined the role of A2B ARs in adipose tissue inflammation and insulin resistance...
  45. Berger S, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, et al. Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. J Immunol. 2014;192:5476-80 pubmed publisher
    ..the balance of RIP1 kinase activity and scaffolding function in vivo during development and TNF-dependent inflammation has been hampered by the perinatal lethality of RIP1-deficient mice...
  46. Bjørndal B, Berge C, Ramsvik M, Svardal A, Bohov P, Skorve J, et al. A fish protein hydrolysate alters fatty acid composition in liver and adipose tissue and increases plasma carnitine levels in a mouse model of chronic inflammation. Lipids Health Dis. 2013;12:143 pubmed publisher
    ..The aim of the study was to determine if FPH could influence fatty acid metabolism and inflammation in transgene mice expressing human tumor necrosis factor alpha (hTNF?).
  47. Ofengeim D, Yuan J. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol. 2013;14:727-36 pubmed publisher
    ..Targeting RIP1 might be a novel therapeutic strategy for the treatment of both acute and chronic human diseases. ..
  48. Wilson C, McLaughlin L, Nair A, Ebenezer P, Dange R, Francis J. Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. PLoS ONE. 2013;8:e76146 pubmed publisher
    ..we measured damaging reactive oxygen species and inflammatory cytokines to determine if oxidative stress and inflammation in the brain, adrenal glands, and systemic circulation were upregulated in response to constant stress...
  49. Elinav E, Nowarski R, Thaiss C, Hu B, Jin C, Flavell R. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013;13:759-71 pubmed publisher
    b>Inflammation is a fundamental innate immune response to perturbed tissue homeostasis. Chronic inflammatory processes affect all stages of tumour development as well as therapy...
  50. Hwang Y, Kim J, Shin J, Kim J, Seo J, Webster M, et al. Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia. Transl Psychiatry. 2013;3:e321 pubmed publisher
    ..studies identified several biological processes including synaptic function, mitochondrial function and immune/inflammation response as altered in the cortex of subjects with schizophrenia...
  51. Benoit B, Plaisancie P, Awada M, Geloen A, Estienne M, Capel F, et al. High-fat diet action on adiposity, inflammation, and insulin sensitivity depends on the control low-fat diet. Nutr Res. 2013;33:952-60 pubmed publisher
    ..the effect of sy-HF on body weight gain, subcutaneous adipose tissue, insulin sensitivity, and adipose tissue inflammation were modified according to the control LFD...
  52. Torres Rosas R, Yehia G, Peña G, Mishra P, del Rocio Thompson Bonilla M, Moreno Eutimio M, et al. Dopamine mediates vagal modulation of the immune system by electroacupuncture. Nat Med. 2014;20:291-5 pubmed publisher
    ..Neuronal networks represent physiological mechanisms, selected by evolution to control inflammation, that can be exploited for the treatment of inflammatory and infectious disorders...
  53. Jones S, Paynich M, Kearns D, Knight K. Protection from intestinal inflammation by bacterial exopolysaccharides. J Immunol. 2014;192:4813-20 pubmed publisher
    ..Previous studies demonstrated that administration of a single dose of Bacillus subtilis prevented disease and inflammation by the enteric mouse pathogen Citrobacter rodentium, which causes disease similar to the human pathogen ..
  54. Harris C, Chowanadisai W, Mishchuk D, Satre M, Slupsky C, Rucker R. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem. 2013;24:2076-84 pubmed publisher
    ..In study 2, PQQ was administered as a daily dose (0.3 mg PQQ/kg). After 76 h, measurements included indices of inflammation [plasma C-reactive protein, interleukin (IL)-6 levels], standard clinical indices (e.g...
  55. Zhang R, Lao L, Ren K, Berman B. Mechanisms of acupuncture-electroacupuncture on persistent pain. Anesthesiology. 2014;120:482-503 pubmed publisher
    ..Additional studies suggest that electroacupuncture, when combined with low dosages of conventional analgesics, provides effective pain management which can forestall the side effects of often-debilitating pharmaceuticals. ..
  56. Atsumi T, Singh R, Sabharwal L, Bando H, Meng J, Arima Y, et al. Inflammation amplifier, a new paradigm in cancer biology. Cancer Res. 2014;74:8-14 pubmed publisher
    Tumor-associated inflammation can induce various molecules expressed from the tumors themselves or surrounding cells to create a microenvironment that potentially promotes cancer development...
  57. Mudgal J, Gowdra V, Mathew G, Nayak P, Reddy N, Namdeo N, et al. Remedial effects of novel 2,3-disubstituted thiazolidin-4-ones in chemical mediated inflammation. Chem Biol Interact. 2014;210:34-42 pubmed publisher
    ..7 murine macrophages and whole blood. These derivatives attenuated carrageenan-induced acute inflammation in rats...
  58. Arocena A, Onofrio L, Pellegrini A, Carrera Silva A, Paroli A, Cano R, et al. Myeloid-derived suppressor cells are key players in the resolution of inflammation during a model of acute infection. Eur J Immunol. 2014;44:184-94 pubmed publisher
    ..During acute infection with the causative agent of Chagas disease, Trypanosoma cruzi, BALB/c mice show less inflammation and better survival than C57BL/6 (B6) mice...
  59. Shrestha S, Irvin M, Grunfeld C, Arnett D. HIV, inflammation, and calcium in atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34:244-50 pubmed publisher
    ..biological processes are postulated to accelerate progression of atherosclerosis in the context of HIV: (1) inflammation, (2) transformation of monocytes to macrophages and then foam cells, and (3) apoptosis of foam cells leading to ..
  60. Rogoz K, Andersen H, Kullander K, Lagerström M. Glutamate, substance P, and calcitonin gene-related peptide cooperate in inflammation-induced heat hyperalgesia. Mol Pharmacol. 2014;85:322-34 pubmed publisher
    ..receptor potential cation channel subfamily V member 1 (TRPV1) is known as a thermosensor and integrator of inflammation-induced hyperalgesia...
  61. Do J, Asosingh K, Baldwin W, Min B. Cutting edge: IFN-?R signaling in non-T cell targets regulates T cell-mediated intestinal inflammation through multiple mechanisms. J Immunol. 2014;192:2537-41 pubmed publisher
    Naive CD4 T cells transferred into lymphopenic mice undergo spontaneous proliferation and induce chronic inflammation in the intestine. Cellular mechanisms regulating the proliferative and inflammatory processes are not fully understood...
  62. Roxburgh C, McMillan D. Cancer and systemic inflammation: treat the tumour and treat the host. Br J Cancer. 2014;110:1409-12 pubmed publisher
    ..There are important parallels with the development of useful treatments for the systemic inflammatory response in patients with rheumatological disease and cardiovascular disease. ..
  63. Idzko M, Ferrari D, Eltzschig H. Nucleotide signalling during inflammation. Nature. 2014;509:310-7 pubmed publisher
    ..Conversely, P2X/P2Y signalling can promote chronic inflammation during ischaemia and reperfusion injury, inflammatory bowel disease or acute and chronic diseases of the lungs...
  64. Zhang Y, Zhang L, Wu J, Di C, Xia Z. Heme oxygenase-1 exerts a protective role in ovalbumin-induced neutrophilic airway inflammation by inhibiting Th17 cell-mediated immune response. J Biol Chem. 2013;288:34612-26 pubmed publisher
    Allergic asthma is conventionally considered as a Th2 immune response characterized by eosinophilic inflammation. Recent investigations revealed that Th17 cells play an important role in the pathogenesis of non-eosinophilic asthma (NEA), ..
  65. Gerner R, Wieser V, Moschen A, Tilg H. Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver. Can J Physiol Pharmacol. 2013;91:867-72 pubmed publisher
    ..e., cytokines, are increasingly recognized as being of crucial importance in metabolic inflammation as observed in morbid obesity and type 2 diabetes (T2D)...
  66. Jiao H, Zhang Y, Yan Z, Wang Z, Liu G, Minshall R, et al. Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation. J Immunol. 2013;191:6191-9 pubmed publisher
    ..was required for the interaction with TLR4 and activation of TLR4-MyD88 signaling and sepsis-induced lung inflammation. Inhibiting caveolin-1 Tyr(14) phosphorylation and resultant inactivation of TLR4 signaling in pulmonary ..
  67. Shiels M, Pfeiffer R, Hildesheim A, Engels E, Kemp T, Park J, et al. Circulating inflammation markers and prospective risk for lung cancer. J Natl Cancer Inst. 2013;105:1871-80 pubmed publisher
    Despite growing recognition of an etiologic role for inflammation in lung carcinogenesis, few prospective epidemiologic studies have comprehensively investigated the association of circulating inflammation markers with lung cancer.
  68. Ballesteros I, Cuartero M, Pradillo J, de la Parra J, Pérez Ruiz A, Corbí A, et al. Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPAR? and 5-LO-dependent pathways. J Leukoc Biol. 2014;95:587-98 pubmed publisher
    ..Moreover, CD36 expression helped resolution of inflammation through phagocytosis, concomitantly to neuroprotection...
  69. Espley R, Butts C, Laing W, Martell S, Smith H, McGhie T, et al. Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice. J Nutr. 2014;144:146-54 pubmed publisher
    Apples are rich in polyphenols, which provide antioxidant properties, mediation of cellular processes such as inflammation, and modulation of gut microbiota...
  70. Kwon O, Zhang L, Ittmann M, Xin L. Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. Proc Natl Acad Sci U S A. 2014;111:E592-600 pubmed publisher
    Chronic inflammation has been shown to promote the initiation and progression of diverse malignancies by inducing genetic and epigenetic alterations...
  71. Kono H, Onda A, Yanagida T. Molecular determinants of sterile inflammation. Curr Opin Immunol. 2014;26:147-56 pubmed publisher
    ..g. pathogens). In addition, sterile necrosis leads to innate immune-mediated acute inflammation. The dying cells still represent a threat to the body that should be eliminated by the host immune response...
  72. Antonioli L, Blandizzi C, Pacher P, Hasko G. Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer. 2013;13:842-57 pubmed publisher
    ..This Review critically discusses the role of adenosine and its receptors in regulating the complex interplay among immune, inflammatory, endothelial and cancer cells during the course of neoplastic disease. ..
  73. Marlow G, Ellett S, Ferguson I, Zhu S, Karunasinghe N, Jesuthasan A, et al. Transcriptomics to study the effect of a Mediterranean-inspired diet on inflammation in Crohn's disease patients. Hum Genomics. 2013;7:24 pubmed publisher
    b>Inflammation is an essential immune response; however, chronic inflammation results in disease including Crohn's disease...
  74. Flesher R, Herbert C, Kumar R. Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma. Clin Sci (Lond). 2014;126:805-14 pubmed publisher
    ..weeks, followed by a single moderate-level challenge to simulate an allergen-induced exacerbation of asthmatic inflammation. Induction of an exacerbation was associated with rapid recruitment of neutrophils, lymphocytes and eosinophils,..
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    ..Inflammatory mediators regulate aromatase expression in the human breast as one mechanism whereby they increase the risk of breast cancer, especially in women who are obese. ..
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    Chronic inflammation is known to promote metabolic dysregulation in obesity and type 2 diabetes...
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    ..Similarly to severe human anemia of inflammation, the B abortus model shows multifactorial pathogenesis of inflammatory anemia including iron restriction from ..
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    ..DM), polymyositis, and inclusion body myositis, which share the characteristics of chronic muscle inflammation and skeletal muscle wasting, are poorly understood...
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    Chronic inflammation induced by endotoxin from a dysbiotic gut microbiota contributes to the development of obesity-related metabolic disorders...
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    ..miR-125a-5p targets KLF13, a transcriptional factor that has an important role in T lymphocyte activation and inflammation. KLF13 knockdown had similar effects on M1 activation as did miR-125a-5p overexpression...
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    ..recently emerged as a critical immune regulator by suppressing T cell immunity and macrophage activation during inflammation, but its role in dendritic cells (DCs) remains unknown...