death

Summary

Summary: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.

Top Publications

  1. Norton M, Smith K, Østbye T, Tschanz J, Schwartz S, Corcoran C, et al. Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: the Cache County study. Am J Geriatr Psychiatry. 2011;19:814-24 pubmed publisher
    Early parental death is associated with lifelong tendencies toward depression and chronic stress. We tested the hypothesis that early parental death is associated with higher risk for Alzheimer disease (AD) in offspring...
  2. Hernadez Alejandro R, Wall W, Jevnikar A, Luke P, Sharpe M, Russell D, et al. Organ donation after cardiac death: donor and recipient outcomes after the first three years of the Ontario experience. Can J Anaesth. 2011;58:599-605 pubmed publisher
    The aim of this study was to explore donor and recipient outcomes from organ donation after cardiac death (DCD) in Ontario and to examine the impact of DCD on deceased donation rates in Ontario since its implementation...
  3. Wang D, Sun J, Solomon S, Klein H, Natanson C. Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion. 2012;52:1184-95 pubmed publisher
    ..b>Death was the outcome of interest...
  4. Deng R, Gu G, Wang D, Tai Q, Wu L, Ju W, et al. Machine perfusion versus cold storage of kidneys derived from donation after cardiac death: a meta-analysis. PLoS ONE. 2013;8:e56368 pubmed publisher
    In response to the increased organ shortage, organs derived from donation after cardiac death (DCD) donors are becoming an acceptable option once again for clinical use in transplantation...
  5. Ohsumi A, Chen F, Sakamoto J, Nakajima D, Hijiya K, Motoyama H, et al. Protective effect of pre-recovery surfactant inhalation on lungs donated after cardiac death in a canine lung transplantation model. J Heart Lung Transplant. 2012;31:1136-42 pubmed publisher
    Warm ischemia-reperfusion injury related to donation after cardiac death is a crucial issue in transplantation...
  6. Rallidis L, Tellis C, Lekakis J, Rizos I, Varounis C, Charalampopoulos A, et al. Lipoprotein-associated phospholipase A(2) bound on high-density lipoprotein is associated with lower risk for cardiac death in stable coronary artery disease patients: a 3-year follow-up. J Am Coll Cardiol. 2012;60:2053-60 pubmed publisher
    ..The aim of this study was to examine the prognostic value of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associated with high-density lipoprotein (HDL) (HDL-Lp-PLA(2)) in patients with stable coronary artery disease (CAD)...
  7. Nagaraja P, Roberts G, Stephens M, Horváth S, Fialova J, Chavez R, et al. Influence of delayed graft function and acute rejection on outcomes after kidney transplantation from donors after cardiac death. Transplantation. 2012;94:1218-23 pubmed publisher
    ..exert an adverse impact on graft outcomes after kidney transplantation using organs from donation after brain-stem death (DBD) donors...
  8. Mason D, Brown C, Murthy S, Vakil N, Lyon C, Budev M, et al. Growing single-center experience with lung transplantation using donation after cardiac death. Ann Thorac Surg. 2012;94:406-11; discussion 411-2 pubmed publisher
    Early experience with lung transplantation (LTx) using organs from donors after cardiac death (DCD) has been promising, although widespread adoption has been slow because of the perception of diminished organ quality...
  9. Trammell R, Cox L, Toth L. Markers for heightened monitoring, imminent death, and euthanasia in aged inbred mice. Comp Med. 2012;62:172-8 pubmed
    The goal of this study was to identify objective criteria that would reliably predict spontaneous death in aged inbred mice...

More Information

Publications65

  1. Orman E, Barritt A, Wheeler S, Hayashi P. Declining liver utilization for transplantation in the United States and the impact of donation after cardiac death. Liver Transpl. 2013;19:59-68 pubmed publisher
    ..The donor age, the body mass index (BMI), and the prevalence of diabetes and donation after cardiac death (DCD) all increased over time, and all 4 factors were independently associated with liver nonuse...
  2. Moorin R, Gibson D, Holman D, Hendrie D. The contribution of age and time-to-death on health care expenditure for out-of-hospital services. J Health Serv Res Policy. 2012;17:197-205 pubmed publisher
    Controversy persists over the relationships between health care expenditure, time-to-death and age, undermining attempts to generate convincing predictions for policy...
  3. Kotzé S, Mole C. Talking about death: implementing peer discussion as a coping mechanism to overcome fears about dissection, death, and dying. Anat Sci Educ. 2013;6:191-8 pubmed publisher
    ..Prior to dissection, first year students are given lectures on aspects of dissection, death and dying, and death rituals in various cultures...
  4. Bathini V, McGregor T, McAlister V, Luke P, Sener A. Renal perfusion pump vs cold storage for donation after cardiac death kidneys: a systematic review. J Urol. 2013;189:2214-20 pubmed publisher
    ..We reviewed evidence of the effectiveness of storing kidneys from deceased donors after cardiac death before transplantation using cold static storage solution or pulsatile hypothermic machine perfusion.
  5. Rady M, Verheijde J. No-touch time in donors after cardiac death (nonheart-beating organ donation). Curr Opin Organ Transplant. 2013;18:140-7 pubmed publisher
    ..To evaluate arterial pulselessness and the no-touch time of 5?min in defining irreversible cessation of cardiorespiratory functions in nonheart-beating donation (NHBD)...
  6. van Walraven C, Wong J, Forster A. LACE+ index: extension of a validated index to predict early death or urgent readmission after hospital discharge using administrative data. Open Med. 2012;6:e80-90 pubmed
    b>Death or urgent readmission after hospital discharge is a common adverse event that can be used to compare outcomes of care between institutions...
  7. Morrissey P, Monaco A. Donation after circulatory death: current practices, ongoing challenges, and potential improvements. Transplantation. 2014;97:258-64 pubmed publisher
    Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide...
  8. Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, et al. A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction. Biochem Biophys Res Commun. 2012;427:280-4 pubmed publisher
    ..667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, ..
  9. Fischer S, Min S, Cervantes L, Kutner J. Where do you want to spend your last days of life? Low concordance between preferred and actual site of death among hospitalized adults. J Hosp Med. 2013;8:178-83 pubmed publisher
    b>Death in the U.S. frequently occurs in institutions despite the overwhelming majority of persons who state that they prefer to die at home...
  10. Kawut S, Barr R, Lima J, Praestgaard A, Johnson W, Chahal H, et al. Right ventricular structure is associated with the risk of heart failure and cardiovascular death: the Multi-Ethnic Study of Atherosclerosis (MESA)--right ventricle study. Circulation. 2012;126:1681-8 pubmed publisher
    ..We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline...
  11. Lipuma S. Continuous sedation until death as physician-assisted suicide/euthanasia: a conceptual analysis. J Med Philos. 2013;38:190-204 pubmed publisher
    A distinction is commonly drawn between continuous sedation until death and physician-assisted suicide/euthanasia. Only the latter is found to involve killing, whereas the former eludes such characterization...
  12. Mishra S, Guan J, Plovie E, Seldin D, Connors L, Merlini G, et al. Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish. Am J Physiol Heart Circ Physiol. 2013;305:H95-103 pubmed publisher
    ..AL-LC injection resulted in impaired cardiac function, pericardial edema, and increased cell death relative to Con-LC, culminating in compromised survival with 100% mortality within 2 wk, independent of AL fibril ..
  13. Ooba N, Setoguchi S, Ando T, Sato T, Yamaguchi T, Mochizuki M, et al. Claims-based definition of death in Japanese claims database: validity and implications. PLoS ONE. 2013;8:e66116 pubmed publisher
    For the pending National Claims Database in Japan, researchers will not have access to death information in the enrollment files. We developed and evaluated a claims-based definition of death.
  14. Wadei H, Heckman M, Rawal B, Taner C, Farahat W, Nur L, et al. Comparison of kidney function between donation after cardiac death and donation after brain death kidney transplantation. Transplantation. 2013;96:274-81 pubmed publisher
    Kidney graft survival is comparable between donation after cardiac death (DCD) and donation after brain death (DBD) kidney transplantation. However, data concerning kidney function after DCD kidney transplantation are lacking.
  15. Lambert A, Stadler T. Birth-death models and coalescent point processes: the shape and probability of reconstructed phylogenies. Theor Popul Biol. 2013;90:113-28 pubmed publisher
  16. Bastami S, Matthes O, Krones T, Biller Andorno N. Systematic review of attitudes toward donation after cardiac death among healthcare providers and the general public. Crit Care Med. 2013;41:897-905 pubmed publisher
    Organ donation after cardiac death (DCD) is one promising possibility of combating the organ shortage, but it raises ethical issues that differ from those raised in donation after brain death (DBD)...
  17. Shah S, Carey I, Harris T, Dewilde S, Victor C, Cook D. Do good health and material circumstances protect older people from the increased risk of death after bereavement?. Am J Epidemiol. 2012;176:689-98 pubmed publisher
    An increased risk of death in persons who have suffered spousal bereavement has been described in many populations. The impact of modifying factors, such as chronic disease and material circumstances, is less well understood...
  18. Ko W, Beccaro M, Miccinesi G, Van Casteren V, Donker G, Onwuteaka Philipsen B, et al. Awareness of general practitioners concerning cancer patients' preferences for place of death: evidence from four European countries. Eur J Cancer. 2013;49:1967-74 pubmed publisher
    ..healthcare systems and they supposedly have a role in supporting cancer patients in achieving their desired place of death. A four-country (Belgium, the Netherlands, Italy and Spain) study was carried out exploring current practices.
  19. Lodhi S, Lamb K, Uddin I, Meier Kriesche H. Pulsatile pump decreases risk of delayed graft function in kidneys donated after cardiac death. Am J Transplant. 2012;12:2774-80 pubmed publisher
    ..have been under scrutiny to determine the best preservation method, particularly in donation after cardiac death (DCD) kidneys...
  20. Barclay J, Kuchibhatla M, Tulsky J, Johnson K. Association of hospice patients' income and care level with place of death. JAMA Intern Med. 2013;173:450-6 pubmed publisher
    ..Terminally ill patients with lower incomes are less likely to die at home, even with hospice care...
  21. Wubshet M, Berhane Y, Worku A, Kebede Y. Death and seeking alternative therapy largely accounted for lost to follow-up of patients on ART in northwest Ethiopia: a community tracking survey. PLoS ONE. 2013;8:e59197 pubmed publisher
    ..Tracking patients lost to follow-up and understanding their status is essential to maintain program quality and to develop targeted interventions to prevent LTF. We aimed to determine the outcome and factors associated with LTF...
  22. Van Orden K, Simning A, Conwell Y, Skoog I, Waern M. Characteristics and comorbid symptoms of older adults reporting death ideation. Am J Geriatr Psychiatry. 2013;21:803-10 pubmed publisher
    To determine whether death ideation in late life is associated with markers of elevated risk for suicide, or reflects normal psychological processes in later life.
  23. Neyrinck A, Van Raemdonck D, Monbaliu D. Donation after circulatory death: current status. Curr Opin Anaesthesiol. 2013;26:382-90 pubmed publisher
    ..Donation after circulatory death (DCD) has opened new perspectives and could be a valuable option to expand the brain-dead donors...
  24. Currow D, Stevenson J, Abernethy A, Plummer J, Shelby James T. Prescribing in palliative care as death approaches. J Am Geriatr Soc. 2007;55:590-5 pubmed
    ..To determine how prescribing for comorbid illnesses and symptom control changes during the palliative phase of a terminal illness...
  25. Nishimura M, Tsukamoto K, Hasebe N, Tamaki N, Kikuchi K, Ono T. Prediction of cardiac death in hemodialysis patients by myocardial fatty acid imaging. J Am Coll Cardiol. 2008;51:139-45 pubmed publisher
    The aim was to evaluate the potential of single-photon emission computed tomography (SPECT) to predict cardiac death in chronic hemodialysis patients using the iodinated fatty acid analogue iodine-123 123I-beta-methyl iodophenyl-..
  26. Maheshwari A, Maley W, Li Z, Thuluvath P. Biliary complications and outcomes of liver transplantation from donors after cardiac death. Liver Transpl. 2007;13:1645-53 pubmed
    Biliary complications after liver transplantation (LT) using organs retrieved from donors after cardiac death are not well characterized...
  27. Rojas Pena A, Hall C, Cook K, Bartlett R, Arenas J, Punch J. Timing of heparin and perfusion temperature during procurement of organs with extracorporeal support in donors after circulatory determination of death. ASAIO J. 2011;57:368-74 pubmed publisher
    Despite successful resuscitation of donors after circulatory determination of death (DCD) with extracorporeal support (ECS), the technique is limited by ethical concerns about donor management (heparinization) and the complexity to ..
  28. Oberender F, Tibballs J. Withdrawal of life-support in paediatric intensive care--a study of time intervals between discussion, decision and death. BMC Pediatr. 2011;11:39 pubmed publisher
    Scant information exists about the time-course of events during withdrawal of life-sustaining treatment. We investigated the time required for end-of-life decisions, subsequent withdrawal of life-sustaining treatment and the time to death.
  29. Hornby K, Hornby L, Shemie S. A systematic review of autoresuscitation after cardiac arrest. Crit Care Med. 2010;38:1246-53 pubmed publisher
    There is a lack of consensus on how long circulation must cease for death to be determined after cardiac arrest. The lack of scientific evidence concerning autoresuscitation influences the practice of organ donation after cardiac death...
  30. Olivola C, Sagara N. Distributions of observed death tolls govern sensitivity to human fatalities. Proc Natl Acad Sci U S A. 2009;106:22151-6 pubmed publisher
    ..the loss of human lives depends largely on the extent to which we are moved by the size of their associated death tolls...
  31. Chochinov H. Death, time and the theory of relativity. J Pain Symptom Manage. 2011;42:460-3 pubmed publisher
    ..This fails to recognize that the value of time, particularly quality time, appears to increase as death draws near...
  32. Sun Y, Chien K, Hsu H, Su T, Chen M, Lee Y. Use of serum homocysteine to predict stroke, coronary heart disease and death in ethnic Chinese. 12-year prospective cohort study. Circ J. 2009;73:1423-30 pubmed
    Prospective data about the association between serum total homocysteine (Hcy) and vascular disease in Asia is limited because few investigations have evaluated the cutpoint of Hcy for predicting the risk of vascular disease and death.
  33. Jokela M, Elovainio M, Singh Manoux A, Kivimaki M. IQ, socioeconomic status, and early death: The US National Longitudinal Survey of Youth. Psychosom Med. 2009;71:322-8 pubmed publisher
    ..To assess whether the association between cognitive ability (IQ) and early mortality is mediated by socioeconomic status (SES) or whether the association between SES and mortality reflects a spurious association caused by IQ...
  34. Muramatsu N, Hoyem R, Yin H, Campbell R. Place of death among older Americans: does state spending on home- and community-based services promote home death?. Med Care. 2008;46:829-38 pubmed publisher
    ..States vary greatly in their proportion of home deaths. Although individuals' circumstances largely determine where they die, health policies may affect the range of options available to them...
  35. Williams B, Woodby L, Bailey F, Burgio K. Identifying and responding to ethical and methodological issues in after-death interviews with next-of-kin. Death Stud. 2008;32:197-236 pubmed publisher
    After-death research with next-of-kin can enhance our understanding of end-of-life care and translate into better services for dying persons and their survivors...
  36. Tibballs J. Organ donation after cardiac death: legal and ethical justifications for antemortem interventions. Med J Aust. 2008;188:186-7; author reply 188 pubmed
  37. Reb A. Transforming the death sentence: elements of hope in women with advanced ovarian cancer. Oncol Nurs Forum. 2007;34:E70-81 pubmed
    ..To describe the experience of hope in women with advanced ovarian cancer...
  38. Burk R, Hill K, Olson G, Weeber E, Motley A, Winfrey V, et al. Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. J Neurosci. 2007;27:6207-11 pubmed
    ..Feeding a selenium-deficient diet to apoER2-/- mice led to neurological dysfunction and death, with some of the characteristics exhibited by Sepp1-/- mice fed the same diet...
  39. Lamers L. The transformation of utilities for health states worse than death: consequences for the estimation of EQ-5D value sets. Med Care. 2007;45:238-44 pubmed
    Utilities for health are measured on an interval scale, where 1 refers to full health and 0 refers to death. No theoretical lower boundary on the utilities for states worse than death exists...
  40. Childress J. Organ donation after circulatory determination of death: lessons and unresolved controversies. J Law Med Ethics. 2008;36:766-71, 610 pubmed publisher
    ..symposium of the Journal of Law, Medicine & Ethics on uncontrolled organ donation following circulatory death (uDCD)...
  41. Holdsworth L, Fisher S. A retrospective analysis of preferred and actual place of death for hospice patients. Int J Palliat Nurs. 2010;16:424, 426, 428 passim pubmed
    The purpose of this study was to explore recording rates of preferences, and the preferred and actual place of death among hospice patients. Data was collected retrospectively from a group of three hospices over a 6-month period...
  42. Jakobsen I, Christiansen E. Young people's risk of suicide attempts in relation to parental death: a population-based register study. J Child Psychol Psychiatry. 2011;52:176-83 pubmed publisher
    The objective of this study was to examine the association between the death of a biological parent and subsequent suicide attempts by young people (aged 10-22 years), and to explore sociodemographic factors as modifying factors in the ..
  43. Min S, Kim S, Park Y, Min S, Kim Y, Ahn C, et al. Trends in deceased organ donation and utilization in Korea: 2000-2009. J Korean Med Sci. 2010;25:1122-7 pubmed publisher
    ..attributable to increases in the number and percentage of extended criteria donors (ECD) and donors after cardiac death (DCD), since the OTPD was 2.25 for DCD, 2.5 for ECD, and 3.09 for SCD in 2009...
  44. van Lommel P. Near-death experiences: the experience of the self as real and not as an illusion. Ann N Y Acad Sci. 2011;1234:19-28 pubmed publisher
    Because the publication of several prospective studies on near-death experience (NDE) in survivors of cardiac arrest have shown strikingly similar results and conclusions, the phenomenon of the NDE can no longer be scientifically ignored...
  45. Machnicki G, Pinsky B, Takemoto S, Balshaw R, Salvalaggio P, Buchanan P, et al. Predictive ability of pretransplant comorbidities to predict long-term graft loss and death. Am J Transplant. 2009;9:494-505 pubmed publisher
    ..Classifications Software (CCS), Charlson and Elixhauser comorbidities and used Cox regressions for graft loss, death with function (DWF) and death...
  46. Klijs B, Mackenbach J, Kunst A. Disability occurrence and proximity to death. Disabil Rehabil. 2010;32:1733-41 pubmed publisher
    This paper aims to assess whether disability occurrence is related more strongly to proximity to death than to age.
  47. Rady M, Verheijde J, McGregor J. Organ procurement after cardiocirculatory death: a critical analysis. J Intensive Care Med. 2008;23:303-12 pubmed publisher
    ..have been introduced requiring hospitals to develop policies for organ donation after cardiac (or circulatory) death (DCD)...
  48. Hernandez Alejandro R, Croome K, Quan D, Mawardi M, Chandok N, Dale C, et al. Increased risk of severe recurrence of hepatitis C virus in liver transplant recipients of donation after cardiac death allografts. Transplantation. 2011;92:686-9 pubmed publisher
    In hepatitis C virus (HCV) recipients of donation after cardiac death (DCD) grafts, there is suggestion of lower rates of graft survival, indicating that DCD grafts themselves may represent a significant risk factor for severe recurrence ..
  49. Bellingham J, Santhanakrishnan C, Neidlinger N, Wai P, Kim J, Niederhaus S, et al. Donation after cardiac death: a 29-year experience. Surgery. 2011;150:692-702 pubmed publisher
    To report the long-term outcomes of 1218 organs transplanted from donation after cardiac death (DCD) donors from January 1980 through December 2008.
  50. Summers D, Johnson R, Allen J, Fuggle S, Collett D, Watson C, et al. Analysis of factors that affect outcome after transplantation of kidneys donated after cardiac death in the UK: a cohort study. Lancet. 2010;376:1303-11 pubmed publisher
    A third of all kidneys from deceased donors in the UK are donated after cardiac death, but concerns have been raised about the long-term outcome of such transplants...
  51. Ray M, Johnston N, Verhulst S, Trammell R, Toth L. Identification of markers for imminent death in mice used in longevity and aging research. J Am Assoc Lab Anim Sci. 2010;49:282-8 pubmed
    The goal of this study was to identify objective criteria that would reliably predict imminent death in aged mice...
  52. Bartlett A, Vara R, Muiesan P, Mariott P, Dhawan A, Mieli Vergani G, et al. A single center experience of donation after cardiac death liver transplantation in pediatric recipients. Pediatr Transplant. 2010;14:388-92 pubmed publisher
    ..8 months (1.7-74 months). LT with DCD grafts in pediatric recipients can be performed with low morbidity and excellent short-to-medium term patient and graft outcome...
  53. Reznik O, Bagnenko S, Loginov I, Iljina V, Ananyev A, Eremich S, et al. Machine perfusion as a tool to select kidneys recovered from uncontrolled donors after cardiac death. Transplant Proc. 2008;40:1023-6 pubmed publisher
    The use of kidneys from uncontrolled donors after cardiac death (uDCD) remains disputable due to significant warm ischemia time (WIT) causing ischemia-reperfusion injuries...
  54. Houttekier D, Cohen J, Bilsen J, Addington Hall J, Onwuteaka Philipsen B, Deliens L. Place of death in metropolitan regions: metropolitan versus non-metropolitan variation in place of death in Belgium, The Netherlands and England. Health Place. 2010;16:132-9 pubmed publisher
    Place of death is an important societal indicator of end-of-life quality for the terminally ill...
  55. Khushf G. A matter of respect: a defense of the dead donor rule and of a "whole-brain" criterion for determination of death. J Med Philos. 2010;35:330-64 pubmed publisher
    Many accounts of the historical development of neurological criteria for determination of death insufficiently distinguish between two strands of interpretation advanced by advocates of a "whole-brain" criterion...
  56. Joffe A, Anton N, Decaen A. Survey of pediatricians' opinions on donation after cardiac death: are the donors dead?. Pediatrics. 2008;122:e967-74 pubmed publisher
    There has been debate in the ethics literature as to whether the donation-after-cardiac-death donor is dead after 5 minutes of absent circulation...