Summary: The feeling-tone accompaniment of an idea or mental representation. It is the most direct psychic derivative of instinct and the psychic representative of the various bodily changes by means of which instincts manifest themselves.

Top Publications

  1. ncbi Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being
    James J Gross
    Department of Psychology, Stanford University, California 94305 2130, USA
    J Pers Soc Psychol 85:348-62. 2003
  2. ncbi Core affect and the psychological construction of emotion
    James A Russell
    Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Psychol Rev 110:145-72. 2003
  3. ncbi DS14: standard assessment of negative affectivity, social inhibition, and Type D personality
    Johan Denollet
    Medical Psychology, Department of Psychology and Health, Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands
    Psychosom Med 67:89-97. 2005
  4. ncbi The benefits of frequent positive affect: does happiness lead to success?
    Sonja Lyubomirsky
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Psychol Bull 131:803-55. 2005
  5. ncbi A time-lagged momentary assessment study on daily life physical activity and affect
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Health Psychol 31:135-44. 2012
  6. ncbi The positive and negative affect schedule (PANAS): construct validity, measurement properties and normative data in a large non-clinical sample
    John R Crawford
    Department of Psychology, King s College, University of Aberdeen, UK
    Br J Clin Psychol 43:245-65. 2004
  7. ncbi Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness
    H S Mayberg
    Research Imaging Center, University of Texas Health Science Center at San Antonio, USA
    Am J Psychiatry 156:675-82. 1999
  8. ncbi Age-related differences and change in positive and negative affect over 23 years
    S T Charles
    Department of Psychology and Social Behavior, University of California, Irvine 92697 7085, USA
    J Pers Soc Psychol 80:136-51. 2001
  9. ncbi Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study
    Y I Sheline
    Department of Psychiatry, Washington University, St. Louis, Missouri 63110, USA
    Biol Psychiatry 50:651-8. 2001
  10. pmc Go and no-go learning in reward and punishment: interactions between affect and effect
    Marc Guitart-Masip
    Institute of Cognitive Neuroscience, University College London, London, W1CN 4AR, UK
    Neuroimage 62:154-66. 2012

Detail Information

Publications357 found, 100 shown here

  1. ncbi Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being
    James J Gross
    Department of Psychology, Stanford University, California 94305 2130, USA
    J Pers Soc Psychol 85:348-62. 2003
    ..regulation strategies such as reappraisal and suppression, and these individual differences have implications for affect, well-being, and social relationships...
  2. ncbi Core affect and the psychological construction of emotion
    James A Russell
    Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Psychol Rev 110:145-72. 2003
    ..These states--called core affect--influence reflexes, perception, cognition, and behavior and are influenced by many causes internal and external, ..
  3. ncbi DS14: standard assessment of negative affectivity, social inhibition, and Type D personality
    Johan Denollet
    Medical Psychology, Department of Psychology and Health, Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands
    Psychosom Med 67:89-97. 2005
    ..This study reports on the Type D Scale-14 (DS14) as a standard measure of NA, SI, and Type D...
  4. ncbi The benefits of frequent positive affect: does happiness lead to success?
    Sonja Lyubomirsky
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Psychol Bull 131:803-55. 2005
    ..that the happiness-success link exists not only because success makes people happy, but also because positive affect engenders success...
  5. ncbi A time-lagged momentary assessment study on daily life physical activity and affect
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Health Psychol 31:135-44. 2012
    ..The current study examined the effects of physical activity on affective state. A primary and within-study replication sample was derived from twin pairs...
  6. ncbi The positive and negative affect schedule (PANAS): construct validity, measurement properties and normative data in a large non-clinical sample
    John R Crawford
    Department of Psychology, King s College, University of Aberdeen, UK
    Br J Clin Psychol 43:245-65. 2004
    ..To evaluate the reliability and validity of the PANAS (Watson, Clark, & Tellegen, 1988b) and provide normative data...
  7. ncbi Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness
    H S Mayberg
    Research Imaging Center, University of Texas Health Science Center at San Antonio, USA
    Am J Psychiatry 156:675-82. 1999
    ..Expanding on this theory, this study examined functional interactions between specific limbic and neocortical regions accompanying normal and disease-associated shifts in negative mood state...
  8. ncbi Age-related differences and change in positive and negative affect over 23 years
    S T Charles
    Department of Psychology and Social Behavior, University of California, Irvine 92697 7085, USA
    J Pers Soc Psychol 80:136-51. 2001
    Positive and negative affect, measured by the Bradburn Affect Balance Scale, were studied in a longitudinal sample spanning from 1971 to 1994. The sample (N = 2,804) represented 4 generations of families...
  9. ncbi Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study
    Y I Sheline
    Department of Psychiatry, Washington University, St. Louis, Missouri 63110, USA
    Biol Psychiatry 50:651-8. 2001
    ..CONCLUSIONS: Depressed patients have left amygdala hyperarousal, even when processing stimuli outside conscious awareness. Increased amygdala activation normalizes with antidepressant treatment...
  10. pmc Go and no-go learning in reward and punishment: interactions between affect and effect
    Marc Guitart-Masip
    Institute of Cognitive Neuroscience, University College London, London, W1CN 4AR, UK
    Neuroimage 62:154-66. 2012
    Decision-making invokes two fundamental axes of control: affect or valence, spanning reward and punishment, and effect or action, spanning invigoration and inhibition...
  11. ncbi Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night
    D F Dinges
    Department of Psychiatry, University of Pennyslvania School of Medicine, Philadelphia 19104-6021, USA
    Sleep 20:267-77. 1997
    ..These findings suggest that cumulative nocturnal sleep debt had a dynamic and escalating analog in cumulative daytime sleepiness and that asymptotic or steady-state sleepiness was not achieved in response to sleep restriction...
  12. ncbi Risk as analysis and risk as feelings: some thoughts about affect, reason, risk, and rationality
    Paul Slovic
    Decision Research, Eugene, OR 97401, USA
    Risk Anal 24:311-22. 2004
    ..It relies on images and associations, linked by experience to emotion and affect (a feeling that something is good or bad)...
  13. pmc The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions
    B L Fredrickson
    Department of Psychology and Research Center for Group Dynamics, Institute for Social Research, University of Michigan, 525 East University Avenue, Ann Arbor, MI 48109 1109, USA
    Am Psychol 56:218-26. 2001
    ..The theory and findings suggest that the capacity to experience positive emotions may be a fundamental human strength central to the study of human flourishing...
  14. pmc Positive affect increases the breadth of attentional selection
    G Rowe
    Department of Psychology, University of Toronto, Toronto, ON, Canada M5S 3G3
    Proc Natl Acad Sci U S A 104:383-8. 2007
    The present study examined the thesis that positive affect may serve to broaden the scope of attentional filters, reducing their selectivity...
  15. ncbi Beyond threat: amygdala reactivity across multiple expressions of facial affect
    Daniel A Fitzgerald
    Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue MC3077 L 466C, Chicago, IL 60637 1470, USA
    Neuroimage 30:1441-8. 2006
    The amygdala has been consistently isolated as a key neural substrate for processing facial displays of affect. Recent evidence from human lesion and functional neuroimaging studies have begun to challenge the notion that the amygdala is ..
  16. ncbi Early improvement in positive rather than negative emotion predicts remission from depression after pharmacotherapy
    Nicole Geschwind
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Eur Neuropsychopharmacol 21:241-7. 2011
    ..The aim of the current study is to examine the contribution of early change in positive affect to the prediction of response to pharmacotherapy...
  17. ncbi Resisting temptation: decreasing alcohol-related affect and drinking behavior by training response inhibition
    Katrijn Houben
    Clinical Psychological Science, Maastricht University, Maastricht, The Netherlands
    Drug Alcohol Depend 116:132-6. 2011
    ..This study demonstrates that repeatedly stopping prepotent responses toward alcohol-related stimuli can be an effective strategy to reduce excessive alcohol use...
  18. ncbi Effects of Hatha yoga and African dance on perceived stress, affect, and salivary cortisol
    Jeremy West
    Reed College, USA
    Ann Behav Med 28:114-8. 2004
    ..Dance and yoga have been shown to produce improvements in psychological well-being...
  19. ncbi A survey method for characterizing daily life experience: the day reconstruction method
    Daniel Kahneman
    Woodrow Wilson School and Department of Psychology, Princeton University, Princeton, NJ 08540, USA
    Science 306:1776-80. 2004
    ..An analysis of the hedonic treadmill shows the DRM's potential for well-being research...
  20. ncbi Does positive affect influence health?
    Sarah D Pressman
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychol Bull 131:925-71. 2005
    This review highlights consistent patterns in the literature associating positive affect (PA) and physical health. However, it also raises serious conceptual and methodological reservations...
  21. ncbi The cognitive benefits of interacting with nature
    Marc G Berman
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
    Psychol Sci 19:1207-12. 2008
  22. pmc Overnight therapy? The role of sleep in emotional brain processing
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, California 94720 1650, USA
    Psychol Bull 135:731-48. 2009
  23. ncbi One year pre-post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients
    Linda E Carlson
    Department of Psychosocial Resources, Tom Baker Cancer Centre Holy Cross Site, Alberta Cancer Board, 2202 Second St S W, Calgary, Alta, Canada T3B 0W7
    Brain Behav Immun 21:1038-49. 2007
  24. ncbi Selective attention and emotional vulnerability: assessing the causal basis of their association through the experimental manipulation of attentional bias
    Colin MacLeod
    Department of Psychology, University of Western Australia, Nedlands, Perth
    J Abnorm Psychol 111:107-23. 2002
  25. ncbi Perceiving affect from arm movement
    F E Pollick
    Department of Psychology, Glasgow University, 58 Hillhead Street, Glasgow G12 8QB, UK
    Cognition 82:B51-61. 2001
    We examined the visual perception of affect from point-light displays of arm movements...
  26. ncbi Effects of yoga program on quality of life and affect in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial
    H S Vadiraja
    Department of Yoga Research, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, India
    Complement Ther Med 17:274-80. 2009
    ..This study compares the effects of an integrated yoga program with brief supportive therapy in breast cancer outpatients undergoing adjuvant radiotherapy at a cancer centre...
  27. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
  28. pmc Serotonin and dopamine: unifying affective, activational, and decision functions
    Roshan Cools
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands
    Neuropsychopharmacology 36:98-113. 2011
  29. ncbi Developing interpretation bias modification as a "cognitive vaccine" for depressed mood: imagining positive events makes you feel better than thinking about them verbally
    Emily A Holmes
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Abnorm Psychol 118:76-88. 2009
    ..Imagining a positive event can make you feel better than thinking about the same event verbally. The authors propose that recruiting imagery will be useful in therapeutic innovations to develop a "cognitive vaccine" for depressed mood...
  30. ncbi The orbitofrontal cortex and beyond: from affect to decision-making
    Edmund T Rolls
    University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, England, United Kingdom
    Prog Neurobiol 86:216-44. 2008
    ..With an origin from beyond the orbitofrontal cortex, top-down attention to affect modulates orbitofrontal cortex representations, and attention to intensity modulates representations in earlier ..
  31. ncbi Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli
    Matthew D Lieberman
    University of California, Los Angeles, CA 90095 1563, USA
    Psychol Sci 18:421-8. 2007
    Putting feelings into words (affect labeling) has long been thought to help manage negative emotional experiences; however, the mechanisms by which affect labeling produces this benefit remain largely unknown...
  32. pmc Fishing for happiness: the effects of generating positive imagery on mood and behaviour
    Arnaud Pictet
    Department of Psychiatry, University of Oxford, UK
    Behav Res Ther 49:885-91. 2011
    ..this finding extends to overtly positive stimuli and whether generating positive imagery can increase positive affect in people with dysphoria...
  33. ncbi Stress-reactivity in psychosis: evidence for an affective pathway to psychosis
    Inez Myin-Germeys
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Clin Psychol Rev 27:409-24. 2007
    ..These findings are discussed in the light of recent biological and psychological mechanisms...
  34. ncbi Animal behaviour: cognitive bias and affective state
    Emma J Harding
    Centre for Behavioural Biology, Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford BS40 5DU, UK
    Nature 427:312. 2004
  35. ncbi Reward counteracts conflict adaptation. Evidence for a role of affect in executive control
    Henk van Steenbergen
    Leiden Institute for Brain and Cognition and Leiden University Institute of Psychology, 2333 AK Leiden, The Netherlands
    Psychol Sci 20:1473-7. 2009
  36. pmc Neural responses to monetary incentives in major depression
    Brian Knutson
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 63:686-92. 2008
    ..In the present study, we compared neural correlates of monetary incentive processing in unmedicated depressed participants and never-depressed control subjects...
  37. ncbi Anger is an approach-related affect: evidence and implications
    Charles S Carver
    Department of Psychology, University of Miami, Coral Gables, FL 33124 0751, USA
    Psychol Bull 135:183-204. 2009
    The authors review a range of evidence concerning the motivational underpinnings of anger as an affect, with particular reference to the relationship between anger and anxiety or fear...
  38. ncbi An inkblot for attitudes: affect misattribution as implicit measurement
    B Keith Payne
    Department of Psychology, The Ohio State University, OH, USA
    J Pers Soc Psychol 89:277-93. 2005
    ..Combining the logic of projective tests with advances in priming research, the affect misattribution procedure (AMP) was sensitive to normatively favorable and unfavorable evaluations (Experiments 1-4)..
  39. ncbi Core affect, prototypical emotional episodes, and other things called emotion: dissecting the elephant
    J A Russell
    Department of Psychology, University of British Columbia, Vancouver, Canada
    J Pers Soc Psychol 76:805-19. 1999
    ..As an illustration, core affect is distinguished from prototypical emotional episode...
  40. ncbi Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings
    Jukka M Leppanen
    Human Information Processing Laboratory, Department of Psychology, University of Tampere, Tampere, Finland
    Curr Opin Psychiatry 19:34-9. 2006
    ..Only the most recent studies, however, have begun to elucidate the specificity and neural basis of these abnormalities. This article reviews and discusses the results of these studies...
  41. ncbi A meta-analysis of 25 years of mood-creativity research: hedonic tone, activation, or regulatory focus?
    Matthijs Baas
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    Psychol Bull 134:779-806. 2008
    ..g., fluency, flexibility, originality, eureka/insight). The authors discuss theoretical implications and highlight avenues for future research on specific moods, creativity, and their relationships...
  42. ncbi Facial affect and affective prosody recognition in first-episode schizophrenia
    J Edwards
    Early Psychosis Prevention and Intervention Centre Mental Health Services for Kids and Youth, North West Health, Victoria, Australia
    Schizophr Res 48:235-53. 2001
    ..Facial affect and affective prosody recognition were examined in representative samples of individuals with first-episode ..
  43. ncbi The Montreal Affective Voices: a validated set of nonverbal affect bursts for research on auditory affective processing
    Pascal Belin
    Department of Psychology, University of Glasgow, Glasgow, Scotland
    Behav Res Methods 40:531-9. 2008
    The Montreal Affective Voices consist of 90 nonverbal affect bursts corresponding to the emotions of anger, disgust, fear, pain, sadness, surprise, happiness, and pleasure (plus a neutral expression), recorded by 10 different actors (5 of ..
  44. ncbi In the mood for adaptation: how affect regulates conflict-driven control
    Henk van Steenbergen
    Leiden Institute for Brain and Cognition, Leiden, The Netherlands
    Psychol Sci 21:1629-34. 2010
    ..Arousal level did not influence conflict adaptation. This study suggests that affect adaptively regulates cognitive control. Implications for future research and psychopathology are discussed.
  45. ncbi Positive affect modulates flexibility and evaluative control
    Nelleke C van Wouwe
    Leiden University
    J Cogn Neurosci 23:524-39. 2011
    ..and neurocomputational work suggests that dopamine release is transiently enhanced by induced positive affect. This ERP study investigated the role of positive affect in different aspects of information processing: in ..
  46. ncbi Impact of mindfulness-based stress reduction (MBSR) on sleep, mood, stress and fatigue symptoms in cancer outpatients
    Linda E Carlson
    Department of Oncology, Department of Psychology, University of Calgary, Calgary, Alberta, Canada
    Int J Behav Med 12:278-85. 2005
    ..There was also a significant reduction in stress (p < .001), mood disturbance (p = .001), and fatigue (p < .001). The associations among these changes and implications for improving quality of life of cancer patients are discussed...
  47. ncbi Positive emotions trigger upward spirals toward emotional well-being
    Barbara L Fredrickson
    Department of Psychology, University of Michigan, Ann Arbor 48109 1109, USA
    Psychol Sci 13:172-5. 2002
    ..The present study assessed this prediction by testing whether positive affect and broad-minded coping reciprocally and prospectively predict one another...
  48. ncbi Attending to the big picture: mood and global versus local processing of visual information
    Karen Gasper
    Department of Psychology, The Pennsylvania State University, University Park 16802, USA
    Psychol Sci 13:34-40. 2002
    ..As predicted, individuals in sad moods were less likely than those in happier moods to classify figures on the basis of globalfeatures...
  49. ncbi What does the prefrontal cortex "do" in affect: perspectives on frontal EEG asymmetry research
    Richard J Davidson
    Laboratory for Affective Neuroscience, W M Keck Laboratory for Functional Neuroimaging and Behavior, University of Wisconsin Madison, 1202 West Johnson Street, Madison, WI 53706, USA
    Biol Psychol 67:219-33. 2004
    ..provides reflections on the current state of affairs in research on EEG frontal asymmetries associated with affect. Although considerable progress has occurred since the first report on this topic 25 years ago, research on ..
  50. ncbi Why the sunny side is up: association between affect and vertical position
    Brian P Meier
    Department of Psychology, North Dakota State University, Fargo, ND 58105, USA
    Psychol Sci 15:243-7. 2004
    Metaphors linking spatial location and affect (e.g., feeling up or down) may have subtle, but pervasive, effects on evaluation. In three studies, participants evaluated words presented on a computer...
  51. ncbi Effects of positive and negative affect on electromyographic activity over zygomaticus major and corrugator supercilii
    Jeff T Larsen
    Department of Psychology, Texas Tech University, Lubbock, Texas 79409, USA
    Psychophysiology 40:776-85. 2003
    ..In addition, positive and negative affect ratings indicated that positive and negative affect have reciprocal effects on activity over corrugator supercilii,..
  52. pmc Deficits in facial affect recognition among antisocial populations: a meta-analysis
    Abigail A Marsh
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neurosci Biobehav Rev 32:454-65. 2008
    Individuals with disorders marked by antisocial behavior frequently show deficits in recognizing displays of facial affect. Antisociality may be associated with specific deficits in identifying fearful expressions, which would implicate ..
  53. ncbi Cerebral pathways in processing of affective prosody: a dynamic causal modeling study
    Thomas Ethofer
    Section of Experimental MR of the CNS, Department of Neuroradiology, Otfried Mueller Strasse 51, University of Tuebingen, 72076 Tuebingen, Germany
    Neuroimage 30:580-7. 2006
  54. ncbi The beneficial effects of additional task load, positive affect, and instruction on the attentional blink
    Christian N L Olivers
    Department of Cognitive Psychology, Vrije Universiteit, Amsterdam, Netherlands
    J Exp Psychol Hum Percept Perform 32:364-79. 2006
  55. ncbi A neuropsychological theory of positive affect and its influence on cognition
    F G Ashby
    Department of Psychology, University of California, Santa Barbara 93106, USA
    Psychol Rev 106:529-50. 1999
    Positive affect systematically influences performance on many cognitive tasks...
  56. ncbi Looking on the bright side: accessing benign meanings reduces worry
    Colette R Hirsch
    Department of Psychology, Institute of Psychiatry, King s College London, UK
    J Abnorm Psychol 118:44-54. 2009
    ..These findings suggest that enhancing access to benign outcomes is an effective method of reducing both the persistence of worry and its detrimental consequences...
  57. ncbi Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients
    Hsing Feng Lee
    Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan
    Pain 153:1301-10. 2012
    ..The visceral placebo analgesia produced heightened activity in affective/cognitive brain regions in IBS patients...
  58. ncbi Fear is only as deep as the mind allows: a coordinate-based meta-analysis of neuroimaging studies on the regulation of negative affect
    Esther Kristina Diekhof
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Germany
    Neuroimage 58:275-85. 2011
    Humans have the ability to control negative affect and perceived fear. Nevertheless, it is still unclear whether this affect regulation capacity relies on a common neural mechanism in different experimental domains...
  59. ncbi Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 195:102-8. 2009
    ..The neuropharmacological actions of antidepressants are well characterised but our understanding of how these changes translate into improved mood are still emerging...
  60. pmc Differential effects of acute and regular physical exercise on cognition and affect
    M E Hopkins
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA
    Neuroscience 215:59-68. 2012
    ..In contrast, a single bout of exercise did not affect recognition memory and resulted in increased perceived stress levels...
  61. ncbi Salivary cortisol in response to acute social rejection and acceptance by peers
    Ginette C Blackhart
    Department of Psychology, East Tennessee State University, PO Box 70649, Johnson City, TN 37614, United States
    Biol Psychol 75:267-76. 2007
    ..g., depression), but laboratory studies examining self-reports of negative affect after social rejection have reported inconsistent results...
  62. ncbi Affect, risk, and decision making
    Paul Slovic
    Decision Research, Eugene, OR 97401, USA
    Health Psychol 24:S35-40. 2005
    ..Reliance on risk as feelings is described with "the affect heuristic." The authors trace the development of this heuristic across a variety of research paths...
  63. ncbi The effects of exercise on body satisfaction and affect
    Marie L Lepage
    Kent State University, Department of Psychology, Kent, OH 44224, United States
    Body Image 7:124-30. 2010
    ..research used ecological momentary assessment to examine the effects of exercise on state body dissatisfaction and affect in 33 undergraduate females with high trait body dissatisfaction and 28 with low trait body dissatisfaction who ..
  64. ncbi Affect 4.0: a free software package for implementing psychological and psychophysiological experiments
    Adriaan Spruyt
    University of Leuven, Belgium
    Exp Psychol 57:36-45. 2010
    We describe Affect 4.0, a user-friendly software package for implementing psychological and psychophysiological experiments. Affect 4.0 can be used to present visual, acoustic, and/or tactile stimuli in highly complex (i.e...
  65. ncbi Attending to affect: appraisal strategies modulate the electrocortical response to arousing pictures
    Greg Hajcak
    Department of Psychology, University of Delaware, Newark, DE, USA
    Emotion 6:517-22. 2006
    ..The results are further discussed in terms of the utility of using the LPP to study emotion regulation...
  66. pmc How emotions inform judgment and regulate thought
    Gerald L Clore
    Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA
    Trends Cogn Sci 11:393-9. 2007
    Being happy or sad influences the content and style of thought. One explanation is that affect serves as information about the value of whatever comes to mind...
  67. ncbi Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior
    E Epel
    UCSF Health Psychology Program, 3333 California St, Suite 465, San Francisco, CA 94118, USA
    Psychoneuroendocrinology 26:37-49. 2001
    ..These results suggest that psychophysiological response to stress may influence subsequent eating behavior. Over time, these alterations could impact both weight and health...
  68. ncbi Negative affect and cue-induced overeating in non-eating disordered obesity
    Anita Jansen
    Maastricht University, Department of Clinical Psychological Science, Maastricht, The Netherlands
    Appetite 51:556-62. 2008
    The recent separation of non-eating disordered obesity into a subtype that is high in negative affect and a subtype that is low in negative affect led to the hypothesis that the two subtypes would show opposite eating responses to typical ..
  69. ncbi How positive affect modulates cognitive control: reduced perseveration at the cost of increased distractibility
    Gesine Dreisbach
    Psychology Department, Dresden University of Technology, Dresden, Germany
    J Exp Psychol Learn Mem Cogn 30:343-53. 2004
    ..The authors show that positive affect plays an important role in the regulation of this stability-flexibility balance...
  70. pmc Simultaneous acquisition of corrugator electromyography and functional magnetic resonance imaging: a new method for objectively measuring affect and neural activity concurrently
    Aaron S Heller
    Department of Psychology University of Wisconsin Madison, Madison, WI 53706, USA
    Neuroimage 58:930-4. 2011
    ..of functional neuroimaging of emotion holds the promise to enhance our understanding of the biological bases of affect and improve our knowledge of psychiatric diseases...
  71. ncbi Feelings change: accounting for individual differences in the temporal dynamics of affect
    Peter Kuppens
    Department of Psychology, University of Leuven, Leuven, Belgium
    J Pers Soc Psychol 99:1042-60. 2010
    ..In this article, we present a theoretical account for the dynamics of affect (DynAffect) that identifies the major processes underlying individual differences in the temporal dynamics of ..
  72. ncbi Feeling the future: experimental evidence for anomalous retroactive influences on cognition and affect
    Daryl J Bem
    Department of Psychology, Uris Hall, Cornell University, Ithaca, NY 14853, USA
    J Pers Soc Psychol 100:407-25. 2011
    ..43. Skepticism about psi, issues of replication, and theories of psi are also discussed...
  73. ncbi The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels
    Simon N Young
    Department of Psychiatry, McGill University, 1033 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada
    Pharmacol Biochem Behav 71:857-65. 2002
    ..Higher levels of serotonin may help to promote more constructive social interactions by decreasing aggression and increasing dominance...
  74. ncbi Momentary affect predicts bodily movement in daily life: an ambulatory monitoring study
    Andreas Schwerdtfeger
    Department of Psychology, Johannes Gutenberg University Mainz, Mainz, Germany
    J Sport Exerc Psychol 32:674-93. 2010
    ..It has been found that aerobic exercise programs can significantly diminish negative affect. Moreover, among healthy individuals, moderate levels of physical activity seem to increase energetic arousal and ..
  75. ncbi Neural correlates of dispositional mindfulness during affect labeling
    J David Creswell
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Psychosom Med 69:560-5. 2007
    ..Converging evidence from the mindfulness and neuroscience literature suggests that labeling affect may be one mechanism for these effects.
  76. ncbi Acoustic correlates of caller identity and affect intensity in the vowel-like grunt vocalizations of baboons
    Drew Rendall
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    J Acoust Soc Am 113:3390-402. 2003
    ..arousal condition was associated primarily with tempo- and source-related features, many matching those identified as vehicles of affect expression in other nonhuman primate species and in human speech and other nonverbal vocal signals.
  77. ncbi Assessment of mindfulness by self-report: the Kentucky inventory of mindfulness skills
    Ruth A Baer
    University of Kentucky, USA
    Assessment 11:191-206. 2004
  78. ncbi A classification of controlled interpersonal affect regulation strategies
    Karen Niven
    University of Sheffield, Institute of Work Psychology, Sheffield, England
    Emotion 9:498-509. 2009
    Controlled interpersonal affect regulation refers to the deliberate regulation of someone else's affect...
  79. ncbi Positive mood and executive function: evidence from stroop and fluency tasks
    Louise H Phillips
    Department of Psychology, University of Aberdeen, Scotland, United Kingdom
    Emotion 2:12-22. 2002
    ..The effect of positive mood on an executive task may therefore depend on whether a task is inherently motivating or is impaired by diffuse semantic activation...
  80. ncbi When inclusion costs and ostracism pays, ostracism still hurts
    Ilja van Beest
    Department of Social and Organizational Psychology, Leiden University, Leiden, Netherlands
    J Pers Soc Psychol 91:918-28. 2006
    ..In these conditions, participants were sensitive to financial incentives. However, even then participants felt worse when given no positive attention than when given punitive attention...
  81. ncbi Mind at ease puts a smile on the face: psychophysiological evidence that processing facilitation elicits positive affect
    P Winkielman
    Department of Psychology, University of Denver, Colorado 80208, USA
    J Pers Soc Psychol 81:989-1000. 2001
    The affect system, in its position to monitor organismic-environmental transactions, may be sensitive to the internal dynamics of information processing...
  82. pmc Preschool-aged children with iron deficiency anemia show altered affect and behavior
    Betsy Lozoff
    Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109 0406, USA
    J Nutr 137:683-9. 2007
    ..Children's social looking toward adults, affect, and wary or hesitant behavior in response to novelty were assessed in a semistructured paradigm during an in-home ..
  83. pmc Anticipatory affect: neural correlates and consequences for choice
    Brian Knutson
    Department of Psychology, Stanford University, Building 420, Jordan Hall, Stanford, CA 94305, USA
    Philos Trans R Soc Lond B Biol Sci 363:3771-86. 2008
    Anticipatory affect' refers to emotional states that people experience while anticipating significant outcomes...
  84. ncbi Effect of acute antidepressant administration on negative affective bias in depressed patients
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 166:1178-84. 2009
    ..The authors investigated whether this effect is apparent in depressed patients early in treatment, prior to changes in mood and symptoms...
  85. ncbi Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients
    Linda E Carlson
    Department Psychosocial Resources, Tom Baker Cancer Centre, Calgary, Alberta, Canada
    Psychosom Med 65:571-81. 2003
  86. ncbi Amygdala, affect and cognition: evidence from 10 patients with Urbach-Wiethe disease
    Michaela Siebert
    Physiological Psychology, University of Bielefeld, D 33501 Bielefeld, Germany
    Brain 126:2627-37. 2003
    ..This suggests that the human amygdala influences both negative and positive emotional processing...
  87. ncbi Estimating the efficiency of recognizing gender and affect from biological motion
    Frank E Pollick
    Department of Psychology, Glasgow University, 58 Hillhead Street, G12 8QB, Glasgow, UK
    Vision Res 42:2345-55. 2002
    ..were presented to participants who were asked to judge the gender of the model in Experiment 1 and the affect in Experiment 2...
  88. pmc The circumplex model of affect: an integrative approach to affective neuroscience, cognitive development, and psychopathology
    Jonathan Posner
    Columbia College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Psychopathol 17:715-34. 2005
    The circumplex model of affect proposes that all affective states arise from cognitive interpretations of core neural sensations that are the product of two independent neurophysiological systems...
  89. pmc Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males
    David O Kennedy
    Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Psychopharmacology (Berl) 211:55-68. 2010
    ..Few studies have assessed the relationship between supplementation with vitamins/minerals and psychological functioning in healthy cohorts of non-elderly adults...
  90. pmc Positive affect and health-related neuroendocrine, cardiovascular, and inflammatory processes
    Andrew Steptoe
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:6508-12. 2005
    ..Here we show that positive affect in middle-aged men and women is associated with reduced neuroendocrine, inflammatory, and cardiovascular activity...
  91. ncbi Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review
    Jane Edwards
    Departments of Psychology and Psychiatry, University of Melbourne, Early Psychosis Prevention and Intervention Center, Parkville, Victoria, Australia
    Clin Psychol Rev 22:789-832. 2002
    Disturbances in affect recognition may be one of the most pervasive and serious aspects of the schizophrenic patient's interpersonal problems...
  92. ncbi Affect modulates appetite-related brain activity to images of food
    William D S Killgore
    Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, Massachusetts, USA
    Int J Eat Disord 39:357-63. 2006
    We examined whether affect ratings predicted regional cerebral responses to high and low-calorie foods.
  93. ncbi Affect-specific modulation of the N1m to shock-conditioned tones: magnetoencephalographic correlates
    Ann Kathrin Bröckelmann
    Institute for Biomagnetism and Biosignalanalysis, University Hospital Munster, Malmedyweg 15, D 48149 Munster, Germany
    Eur J Neurosci 37:303-15. 2013
    ..In line with previous findings from intramodal MultiCS conditioning we found an affect-specific modulation of the auditory N1m component 100-150 ms post-stimulus within a distributed frontal-temporal-..
  94. pmc Response inhibition and psychomotor speed during methadone maintenance: impact of treatment duration, dose, and sleep deprivation
    B K Bracken
    Behavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 125:132-9. 2012
    ..In opiate-dependent individuals, abstinence results in deficits in cognitive functioning, which may be exacerbated by medication-associated sleep disruption...
  95. ncbi Cognitive bias modification: the critical role of active training in modifying emotional responses
    Laura Hoppitt
    School of Social Work and Psychology, University of East Anglia, Norwich NR47TJ, UK
    Behav Ther 41:73-81. 2010
    ..This finding supports the view that active generation of meaning during interpretive training is critical for the modification of later emotional responses...
  96. pmc The impact of emotional well-being on long-term recovery and survival in physical illness: a meta-analysis
    Sanne M A Lamers
    Psychology, Health and Technology, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    J Behav Med 35:538-47. 2012
    ..Medline and PsycInfo) identified 17 eligible studies examining the impact of general well-being, positive affect and life satisfaction on recovery and survival in physically ill patients...
  97. pmc Positive and negative affect and oral health-related quality of life
    David S Brennan
    Australian Research Centre for Population Oral Health, School of Dentistry, The University of Adelaide, South Australia 5005 Australia
    Health Qual Life Outcomes 4:83. 2006
    The aims of the study were to assess the impact of both positive (PA) and negative affect (NA) on self-reported oral health-related quality of life and to determine the effect of including affectivity on the relationship between oral ..
  98. ncbi Maternal depressive symptoms affect infant cognitive development in Barbados
    J R Galler
    Center for Behavioral Development and Mental Retardation, Boston University School of Medicine, MA 02118, USA
    J Child Psychol Psychiatry 41:747-57. 2000
    ..These findings demonstrate the need to carefully monitor maternal moods during the postpartum period, in order to maximize the benefits of breast-feeding and related health programs to infant cognitive development...
  99. ncbi "I see what you're saying": intrusive images from listening to a traumatic verbal report
    Julie Krans
    Behavioural Science Institute, Radboud University Nijmegen, Department of Clinical Psychology, Montessorilaan 3, 6525 HR Nijmegen, The Netherlands
    J Anxiety Disord 24:134-40. 2010
    ..This study provides a valuable addition to models of posttraumatic stress disorder and autobiographical memory. Additionally, the results have potential implications for therapists working with traumatized individuals...
  100. pmc Modifying interpretations among individuals high in anxiety sensitivity
    Shari A Steinman
    Department of Psychology, University of Virginia, P O Box 400400, Charlottesville, VA 22904 4400, United States
    J Anxiety Disord 24:71-8. 2010
    ..Evidence was mixed for the effect of Positive training on emotional vulnerability (small effect for less fear, but not for avoidance). Findings support the causal premise underlying cognitive models of anxiety...
  101. ncbi Anxiety, depression, and the anticipation of future positive and negative experiences
    A K MacLeod
    Department of Psychology, Royal Holloway University of London, Egham, Surrey, England
    J Abnorm Psychol 105:286-9. 1996
    ..The results are discussed in terms of the distinction between positive affect and negative affect (D. Watson, L. A. Clark, & G. Carey, 1988).

Research Grants77

    Keri Hammel; Fiscal Year: 2013
    ..Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the retina, the light sensing area at the back of the eye...
    Keri Hammel; Fiscal Year: 2012
    ..Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the retina, the light sensing area at the back of the eye...
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  5. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  6. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..b. Maintain log of scientific decisions made during the study that affect the study design, conduct, or analysis. c...
  7. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Genetic defects in liver functions affect approximately 1/50,000 live births...
  8. Xenoestrogen regulation of Leydig cells
    ..Several reports in the literature have shown that exposure of rodents and non human primates to soy isoflavones affect testicular androgen secretion...
  9. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..Hence, the X-gene is a tumor suppressor gene. We show that these two sex chromosome genes can affect testosterone (male-hormone) associated physiology, again in opposing directions...
  10. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..The disease is a major public health problem in all societies and is estimated to affect up to 15% of the adult dentate population, with severe forms affecting 5 6%...
  11. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..Adverse menopausal symptoms such as hot flashes affect about 70% of women approaching menopause and The North American Menopause Society posits that over 6,000 American ..
  12. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ..the ER-retention of the H1RR allele and whether pharmacological chaperones can restore H1RR surface expression and affect disease in vivo...
  13. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..product, OPN-Leu (OPN-L), in synovial fluid samples from rheumatoid arthritis patients and these cleaved OPN forms affect neutrophils and fibroblast-like synoviocytes...
  14. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    ..Ser180 within an important regulatory motif and at 3 highly conserved amino acids within the C terminus that may affect binding of the hormone to its cognate receptor (preliminary data, unpublished)...
  15. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..Data from our own and other laboratories, however, show that tyrosine supply can affect dopamine...
  16. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..apoER2', or a common antagonist to members of the LDL receptor family named receptor associated protein (RAP) affect aPL-mediated upregulation of TF, ICAM-1, cytokines and p38 mitogen activated protein kinase (p38 MAPK) ..
  17. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..My career objective is to conduct independent research to understand how stress and affect interact and elucidate their respective roles in the etiology of mental disorders like depression and anxiety...
  18. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..Aim 3: To investigate mechanism of dvUT blockade. We will examine if known mammalian UT blockers affect urea binding and permeation on dvUT, and if so, we will identify blocker binding sites by X-ray crystallography...
    Enrique A Mesri; Fiscal Year: 2013
    ..The tumor is characterized by intense angiogenesis and the proliferation of spindle cells that can affect the skin, mucosa and viscera, causing significant morbidity...
  20. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..whether modulation of SCD1 expression by dietary MR is an essential component of the mechanism used by MR to affect energy homeostasis and limit fat deposition...
  21. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..are necessary a) in order to align quantitative trait loci (QTL) haplotype structure with polymorphisms that may affect gene function e.g. non-synonymous coding SNPs and b) to mask striatal gene expression data...
  22. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..will study how Th2 cells are regulated by protein kinase C? (PKC?) in Project 2, how different IgEs differentially affect mast cell activation in Project 3, and how Treg cells are regulated by Itch, an E3 ubiquitin ligase, in Project 4...
    Melanie H Cobb; Fiscal Year: 2012
    ..enzymes that have been found in screens to identify proteins required for development and survival, and that affect growth in flies, worms, and mammals. WNK1 is essential for embryonic development in mice...
    Gary Cecchini; Fiscal Year: 2013
    ..First, does mitochondrial protein acetylation affect respiratory chain activity and the active/deactive transition of complex I...
  25. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: 7. PROJECT NARRATIVE Cancer will affect 1 in 2 veterans and involuntary weight loss (also known as cachexia) resulting from a loss of fat and muscle mass ..
  26. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..We hypothesize that LRP6 mutation directly affect glycogen synthesis by impairment of glycogen synthase activity...
  27. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..Our central hypothesis is that differences in particulate matter composition affect intracellular phagosome transport via ROS generation...
  28. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..Further, typical NIRS fails to account for shifts in water, fat, blood volume, and stool, any of which can affect oxygenation measurements if not specifically accounted for, making NIRS unreliable for quantitative studies of the ..
  29. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..Our preliminary data demonstrate that modest changes in levels of dietary iron affect circadian regulation of metabolism, in particular of hepatic glucose production...
  30. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Respiratory illnesses affect over two-thirds of Veterans deployed to Iraq or Afghanistan...
    Pi Wan Cheng; Fiscal Year: 2010
    ..Modulation of C2GnT-M gene expression can greatly affect the physicochemical properties of airway mucins and functions of airway mucus...
  32. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..comprehensible data supporting links between actin and apoptosis in eukaryotic cells from studies using drugs that affect actin turnover...
    Adrian R Krainer; Fiscal Year: 2010
    ..PROJECT NARRATIVE - Pre-mRNA splicing and mRNA quality-control are key steps in gene expression. Mutations that affect these processes in specific genes, or that alter the properties or levels of the factors involved in these ..
  34. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dementia and other milder forms of cognitive diseases of the CNS affect HIV-1 infected patients...
    Lisa M Salati; Fiscal Year: 2012
    ..non-pathological fluctuations in dietary fat intake alter intracellular metabolism and how these signaling actions affect events in the nucleus...
  36. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..The chronic loss of sleep may affect the way in which the body's immune system works, and our research in a mouse model of human RA has shown that ..
  37. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..PD) is a neurodegenerative movement disorder which affects 5% of the world population over the age of 85 and may affect some individuals as young as 40. More than 15,000 U.S...
  38. The role of IKK beta in cardiomyocytes at baseline and following stress
    MATTHEW PETER COGGINS; Fiscal Year: 2013
    ..NF-kB inhibition is also being considered in cancer and diabetes, which could affect cardiovascular health. Understanding NF-kB's role in the heart thus has important practical implications...
  39. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..To understand how ROS affect cells, it is essential to monitor their levels...
  40. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013 understanding the role of CD44 isoforms in the regulation of MS and other inflammatory diseases of the CNS that affect a large proportion of Veterans as well provide novel treatment modalities that would benefit Veterans'health...
  41. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..For instance, vitamin D3 (VD3) can affect the functions of immune cells including macrophages, dendritic cells (DC), B and T cells...
  42. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010 this research proposal is: can a popular technique that specifically targets active mastery and improved affect regulation, yoga, which is utilized by approximately 4% of the US population each year (1), improve the ..
    Alvaro Puga; Fiscal Year: 2013
    ..low doses of chromium leads to gradual changes in histone marks and signal transduction pathways that cumulatively affect gene expression and silencing...
  44. Mechanisms of Sex Determination in Zebrafish
    ..death in homozygous mutant juvenile gonads and suggest the hypothesis that 1) environmental and genetic factors affect oocyte survival in juveniles, and thereby 2) alter the strength of an oocyte-derived signal that promotes, in ..
  45. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..Many environmental chemicals, pathogens, drugs or excessive alcohol can harm the liver and affect its function. An estimated 5...
  46. Analysis of gene regulation of Vibrio cholerae during infection
    Jun Zhu; Fiscal Year: 2013
    ..oxide (NO), and oxidative stress from reactive oxygen species (ROS) generated in vivo and how these modifications affect AphB functionality, including posttranslational modification-induced AphB degradation...
  47. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    ..The proposed experiments will elucidate how sequential infection and catheterization affect the course of UTI and aid in better clinical management and the development of new therapeutics for combating this ..
  48. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    ..use in some countries, yet it remains unknown how poor nutritional status or concurrent parasitic infections will affect responses to the vaccines...
  49. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..At the same time, the project will address important, testable questions about the neurobiology of genetic vulnerability to MDD, an identified public health priority. ..
  50. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..illnesses that result from the immune system attacking the body's own tissues, are estimated to adversely affect up to 25 million persons in the U.S...
  51. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..adverse changes, inflammation and toxicity in cervicovaginal tissue in vivo;xiii) is not immunogenic;xiv) does not affect cellular signaling pathways;xv) apparently does not allow viral development resistance;xvi) efficiently blocks HIV ..
  52. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..HOX are highly reactive and oxidatively halogenate proteins to adversely affect cell function...
    Francis W Luscinskas; Fiscal Year: 2013 the regulation of the inflammatory process, which is central to so many pathophysiological conditions that affect the heart and blood vessels (e.g., heart attacks and strokes), as well as other organs and tissues of the body...
  54. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..Studies are needed that will determine whether environmental exposures can affect risk for copy number variation and other structural variations that have been implicated in complex diseases...
  55. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis (CF), and asthma, together, lung diseases that affect millions of individuals world-wide...
  56. Therapeutic Effect of a Novel Antioxidant on Degenerative Eye Disorders
    Nuran Ercal; Fiscal Year: 2012
    ..Diseases such as cataracts and age-related macular degeneration significantly affect quality of life and represent sizable medical costs...
  57. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    ..In addition, we can also use this model to screen drug for treatments of optic atrophy. By understanding how Opa1 affect the life span, we may develop a drug to prolong the life span...
  58. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..Our long-term goal is to understand the molecular and cellular mechanisms by which various factors interact to affect hematopoiesis...
  59. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2012
    ..recent discovery that the Y chromosome of Drosophila melanogaster is polymorphic for sequences that differentially affect the expression of many hundreds of autosomal and X-linked genes...
  60. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    ..forces exerted by the tensor tympani and the stapedius muscles, will also be used to understand how these muscles affect sound transmission through the middle ear...
  61. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012 defined by permanent changes in ovarian function, we still do not understand how postmenopausal sex hormones affect diabetes risk...
  62. Novel Reagents and Methods for Rapid and High Throughput Detection of Aflatoxin C
    ALAN AI PING WEI; Fiscal Year: 2013
    ..They affect 4.5 billion people worldwide and causes up to 150,000 cases of hepatocellular carcinoma each year. In the U.S...
  63. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..In fact, the highest concentrations of MR are in hippocampal neurons involved in memory, learning and affect that also express AS...
  64. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..However, little is known about how those environmental factors affect disease development...
  65. Investigations of the role of house flies as vectors for bacterial pathogens
    Dana Nayduch; Fiscal Year: 2009
    ..nature and indiscriminate feeding habits, house flies are involved in the epidemiology of >65 diseases that affect humans world-wide...
    Greg Hunt; Fiscal Year: 2000
    ..The project will focus on the two identified QTLs recognized to affect defensive behavior in Africanized honey bee colonies...
  67. Indicators of early neurodegeneration: gene-toxin interactions at the syanpse
    Felix E Schweizer; Fiscal Year: 2010
    ..We find that environmental toxins such as pesticides that are implicated in Parkinson's disease (PD) rapidly affect synaptic transmission and synaptic plasticity...
  68. Failure to Utilize Diabetes Health Services Following a Referral
    Andrew John Karter; Fiscal Year: 2010
    ..public health implications, given that repeated non-utilization ("persistent non-utilization") may adversely affect continuity of care, and increase the risk for serious and costly events...
  69. Pseudomonas aeruginosa genomic islands and virulence factors
    VANDERLENE LIU KUNG; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The environment contains a large number of toxins that adversely affect the health of humans...
  70. Economic Restructuring and Social Mobility in Japan
    Wei hsin Yu; Fiscal Year: 2009
    ..Such changes are likely to fundamentally reshape Japan's system of social protection and hence affect its citizens'lifetime economic conditions...
  71. Does Enhanced School-Readiness Affect Adult Health of African Americans?
    Frances A Campbell; Fiscal Year: 2010
    ..Number RFA-OD-09-003 NIH Challenge Grants in Health and Science Research Does Enhanced School-Readiness Affect Adult Health of African Americans? This application addresses Broad Challenge Area (05) Comparative Effectiveness ..
  72. Multispecies competition, indirect effects, and invasion in mosquito communities
    STEVEN JULIANO; Fiscal Year: 2009
    ..To understand how multispecies assemblages of interacting mosquitoes may affect one another directly and indirectly, and the consequences of those effects for vector populations, this project ..
    Peter Ubel; Fiscal Year: 2004
    ..groups, 2) To explore possible reasons for these discrepancies; and 3) to test how alternative utility measures affect the size and direction of the discrepancy, and the reliability and validity of utility assessment...
  74. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..These disorders affect millions of people in the United States every year...
    Charles Lieber; Fiscal Year: 2001
    We plan to pursue our studies of factors that affect activity and inducibility of the microsomal ethanol oxidizing systems (MEOS) and associated functions, and hence their pathologic role in alcohol-induced liver injury...
  76. Changes in Control of Movement Timing and Stability With Muscle Fatigue
    JONATHAN DINGWELL; Fiscal Year: 2009
    ..and effective strategies for rehabilitation, it is critical to understand how fatigue muscle and muscle imbalances affect the control of goal-directed movements...
  77. Megakaryocyte Chemokines & Post-Irradiation Thrombocytopenia
    Mortimer Poncz; Fiscal Year: 2009
    ..PF4 is normally released by megakaryocytes in amounts sufficient to affect platelet counts in both mice and humans with platelet counts inversely related to PF4 content...