identification psychology


Summary: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others.

Top Publications

  1. ncbi The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks
    L A Campfield
    Department of Metabolic Diseases, Hoffmann-La Roche Inc, Nutley, NJ 07110, USA
    Horm Metab Res 28:619-32. 1996
  2. ncbi [Prevention and treatment of febrile neutropenia]
    F Montemurro
    Dipartimento di Scienze Biomediche ed Oncologia Umana, , Italy
    Tumori 83:S15-9. 1997
  3. ncbi CD4+ lymphocyte responses to pulmonary infection with Mycobacterium tuberculosis in naïve and vaccinated BALB/c mice
    C M Mason
    Pulmonary/Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Tuberculosis (Edinb) 81:327-34. 2001
  4. ncbi [CD34+ cells: biological aspects]
    F Benedetti
    Cattedra di Ematologia,
    Tumori 82:S3-13. 1996
  5. ncbi Retention/quantitation properties of the o-phthaldialdehyde-3-mercaptopropionic acid and the o-phthaldialdehyde-N-acetyl-L-cysteine amino acid derivatives in reversed-phase high-performance liquid chromatography
    A Vasanits
    Institute of Inorganic and Analytical Chemistry, , Budapest, Hungary
    J Chromatogr A 870:271-87. 2000
  6. ncbi Menstrual experiences and beliefs: a multicountry study of relationships with fertility and fertility regulating methods
    L J Severy
    College of Liberal Arts and Sciences, University of Florida, Gainesville 32611
    Women Health 20:1-20. 1993
  7. ncbi A systematic overview of chemotherapy effects in acute myeloid leukaemia
    E Kimby
    Department of Haematology, University Hospital, Huddinge, Sweden
    Acta Oncol 40:231-52. 2001
  8. ncbi Differential gene expression in the human ciliary epithelium
    M Coca-Prados
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
    Prog Retin Eye Res 18:403-29. 1999
  9. ncbi Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond
    M A Serabian
    U S Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Therapeutics Research and Review, Rockville, Maryland 20852, USA
    Toxicol Pathol 27:27-31. 1999
  10. ncbi Role of apoptosis in biology and pathology: resistance to apoptosis in colon carcinogenesis
    C M Payne
    Arizona Research Laboratories, University of Arizona, Tucson 85724, USA
    Ultrastruct Pathol 19:221-48. 1995

Detail Information

Publications718 found, 100 shown here

  1. ncbi The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks
    L A Campfield
    Department of Metabolic Diseases, Hoffmann-La Roche Inc, Nutley, NJ 07110, USA
    Horm Metab Res 28:619-32. 1996
    ..Therapeutic approaches to the treatment of obesity based on OB protein ranging from OB protein by injection to OB-R receptor agonists and to upregulation of OB signalling pathways are under intense investigation...
  2. ncbi [Prevention and treatment of febrile neutropenia]
    F Montemurro
    Dipartimento di Scienze Biomediche ed Oncologia Umana, , Italy
    Tumori 83:S15-9. 1997
    ..In the first reports, outpatient treatment has proven to be effective, cost saving and well received by patients, but further studies are needed to accurately define low risk status and the optimal home antibiotic regimens...
  3. ncbi CD4+ lymphocyte responses to pulmonary infection with Mycobacterium tuberculosis in naïve and vaccinated BALB/c mice
    C M Mason
    Pulmonary/Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Tuberculosis (Edinb) 81:327-34. 2001
    ..This will help to improve knowledge concerning radiation conditions inside of spacecrafts, necessary to secure a maximum possible protection to the astronauts...
  4. ncbi [CD34+ cells: biological aspects]
    F Benedetti
    Cattedra di Ematologia,
    Tumori 82:S3-13. 1996
    ..The first data seem to suggest this is a good way to pursue, even if a clinical application remains still far from being satisfying...
  5. ncbi Retention/quantitation properties of the o-phthaldialdehyde-3-mercaptopropionic acid and the o-phthaldialdehyde-N-acetyl-L-cysteine amino acid derivatives in reversed-phase high-performance liquid chromatography
    A Vasanits
    Institute of Inorganic and Analytical Chemistry, , Budapest, Hungary
    J Chromatogr A 870:271-87. 2000
    ..Derivatization of the apple pulp was performed with filtered samples, applying any special isolation processes...
  6. ncbi Menstrual experiences and beliefs: a multicountry study of relationships with fertility and fertility regulating methods
    L J Severy
    College of Liberal Arts and Sciences, University of Florida, Gainesville 32611
    Women Health 20:1-20. 1993
    ..Beliefs, which reflect socialization according to demographic variables, appear to affect choice of methods and family size...
  7. ncbi A systematic overview of chemotherapy effects in acute myeloid leukaemia
    E Kimby
    Department of Haematology, University Hospital, Huddinge, Sweden
    Acta Oncol 40:231-52. 2001
    ..Patients with relapsed AML can only infrequently achieve long-term remissions with chemotherapy in conventional doses. trolled data indicate that allogeneic transplantation can be a curative treatment for these patients a..
  8. ncbi Differential gene expression in the human ciliary epithelium
    M Coca-Prados
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA
    Prog Retin Eye Res 18:403-29. 1999
    ..e., trabecular meshwork cells) by a paracrine mechanism. Finally, we hypothesize that these mechanisms could be entrained in the light-dark cycle following the circadian rhythm of aqueous humor and intraocular pressure...
  9. ncbi Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond
    M A Serabian
    U S Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Therapeutics Research and Review, Rockville, Maryland 20852, USA
    Toxicol Pathol 27:27-31. 1999
  10. ncbi Role of apoptosis in biology and pathology: resistance to apoptosis in colon carcinogenesis
    C M Payne
    Arizona Research Laboratories, University of Arizona, Tucson 85724, USA
    Ultrastruct Pathol 19:221-48. 1995
    ..Thus, a resistance-to-apoptosis bioassay may prove useful as an intermediate biomarker for determining which individuals are at high risk for colon cancer...
  11. ncbi Analysis of codeine, dihydrocodeine and their glucuronides in human urine by electrokinetic capillary immunoassays and capillary electrophoresis-ion trap mass spectrometry
    A B Wey
    Department of Clinical Pharmacology, University of Berne, Switzerland
    J Chromatogr A 895:133-46. 2000
    ..5) and DHC (m/z 478.5) via their fragmentation to COD and DHC, respectively. MSn (n > or = 2) is shown to be capable of properly identifying the urinary codeinoids on the 100-200 ng/ml concentration level...
  12. ncbi Alcoholism in homeless men in the mid-nineties: results from the Bavarian Public Health Study on homelessness
    M Fichter
    Department of Psychiatry, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 249:34-44. 1999
    ..Currently homeless men in Germany are adequately supplied with food, clothes, and shelter but psychiatrically (and medically) neglected. Existing concepts and programs for dealing with these problems need to be implemented...
  13. ncbi Identification, purification and characterization of a putative novel growth-inhibitory and/or apoptotic protein from rat liver
    S S Dadke
    Cellular Carcinogenesis Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India
    Tumori 84:14-20. 1998
    ..CONCLUSIONS: A growth-inhibitory protein of 14 kD can be isolated from normal rat liver. The physiologic role of the protein in liver appears to be either growth regulatory or apoptotic...
  14. ncbi [Can ambulatory arterial blood pressure monitoring taken in the 4th month of pregnancy in normotensive primaparas predict the appearance of a fetomaternal event? Results of a French multicenter study. Report of 170 cases]
    S Ragot
    Service Cardiologie, CHU La Miletrie, Poitiers
    Arch Mal Coeur Vaiss 92:1145-9. 1999
    ..To evaluate in a primigravid normotensive population the predictive value of outcome of the ambulatory blood pressure monitoring (ABPM) at the 4th month of pregnancy...
  15. ncbi Depressive disorders in primary care: prevalence, functional disability, and identification
    J W Williams
    Division of General Internal Medicine, Audie L. Murphy Memorial Veterans Affairs Hospital, San Antonio, TX 78284, USA
    J Gen Intern Med 10:7-12. 1995
    ..Both MDD and SubD were associated with significant functional impairment. The sensitivity of the SDS was lower for identifying depressive disorders (MDD or SubD) than it was for identifying MD...
  16. pmc Survey of state public health departments on procedures for reporting elder abuse
    P Ehrlich
    Community Services, Benjamin Rose Institute, Cleveland, OH 44115
    Public Health Rep 106:151-4. 1991
    ..Health departments can be useful facilitators in the development of interdepartmental coordination to address the complex issues of elder abuse...
  17. pmc The pathobiology of the human enterochromaffin-like cell
    I M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
    Yale J Biol Med 65:775-92; discussion 827-9. 1992
    ..It is possible that the future pharmacotherapy of acid secretory disease may require regulation not only of parietal cell but of ECL-cell function...
  18. ncbi Functional comparison of the yeast scERV1 and scERV2 genes
    G Stein
    Botanisches Institut, , Germany
    Yeast 14:171-80. 1998
  19. ncbi [Alternative surgical options to heart transplantation]
    G Dreyfus
    Service de chirurgie cardiovasculaire, , , Suresnes
    Arch Mal Coeur Vaiss 91:1413-22. 1998
    ..The advantages of these procedures are certain as there is no waiting list, the functional results in good indications have been demonstrated and, if necessary, secondary orthotopic cardiac transplantation is always possible...
  20. ncbi Identification of the location, extent, and pathway of sensory neurologic feedback after mechanical stimulation of a lateral spinal ligament in chickens
    H Jiang
    Department of Surgery, University of Alberta, Edmonton, Canada
    Spine (Phila Pa 1976) 22:17-25. 1997
  21. ncbi Evaluation of housestaff physicians' preparation and interpretation of sputum Gram stains for community-acquired pneumonia
    M J Fine
    Department of Medicine, University of Pittsburgh, Pennsylvania
    J Gen Intern Med 6:189-98. 1991
    ..Housestaff physicians should receive formal training in the preparation and interpretation of Gram stains; the specific defects elucidated in this study warrant special attention...
  22. ncbi Identification of four ovarian receptor proteins that bind vitellogenin but not other homologous plasma lipoproteins in the rainbow trout, Oncorhynchus mykiss
    C R Tyler
    Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UK
    J Comp Physiol B 166:11-20. 1996
  23. ncbi Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent
    W W Li
    Laboratories of Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 7:2908-11. 2001
    ..ET-743 is an extremely potent cytotoxic agent against human STS cell lines and is being evaluated as an antitumor agent in this disease...
  24. ncbi Biochemical characteristics and recent biological knowledge on prostate-specific antigen
    E Seregni
    Nuclear Medicine Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Tumori 82:72-7. 1996
    ..These new findings will have implications for the clinical application of PSA as a tumor marker for prostate cancer...
  25. ncbi Mapping the sentinel lymph node in malignant melanoma by blue dye, lymphoscintigraphy and intraoperative gamma probe
    G Villa
    Nuclear Medicine Service, DIMI, Genoa, Italy
    Tumori 86:343-5. 2000
    ..The latter all underwent SLND of the affected basin. In 10 patients (55.6%) the SN was the only site of tumor invasion; eight patients (44.4%) with positive SNs had one or more metastatic lymph nodes in the draining basin...
  26. ncbi The pathways of cell death: oncosis, apoptosis, and necrosis
    B F Trump
    Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
    Toxicol Pathol 25:82-8. 1997
    ..Genetic evidence strongly indicates that activation of proteases is an important step, possibly very near to the point where cell death occurs...
  27. pmc Breast-feeding, nutritional status, and other prognostic factors for dehydration among young children with diarrhoea in Brazil
    C G Victora
    Department of Social Medicine, Universidade Federal de Pelotas, RS, Brazil
    Bull World Health Organ 70:467-75. 1992
    ..In terms of their sensitivity and specificity, however, these prognostic factors were not as effective as early signs and symptoms for predicting the outcome of the episode...
  28. ncbi Screening and identification of familial defective apolipoprotein B-100 in clinical samples by capillary gel electrophoresis
    R Lehmann
    , Innere Medizin Abteilung IV, Germany
    J Chromatogr A 744:187-94. 1996
    ..The PCR-CGE method on the Dionex capillary electrophoresis system (CES I) allows rapid, fully automated detection of the mutation resulting in the unequivocal diagnosis of FDB...
  29. ncbi Detection of Mycobacterium tuberculosis in formaldehyde solution-fixed, paraffin-embedded tissue by polymerase chain reaction in Pott's disease
    R H Berk
    School of Medicine, Department of Orthopaedics and Traumatology, Dokuz Eylul University, Izmir, Turkey
    Spine (Phila Pa 1976) 21:1991-5. 1996
    ..CONCLUSION: Polymerase chain reaction has a sensitivity of 94.7%, specificity of 83.3%, positive predictive value of 94.7%, and a negative predictive value of 83.3%. Accuracy was calculated as 92%...
  30. ncbi Identification of a gene cluster within the genome of Chilo iridescent virus encoding enzymes involved in viral DNA replication and processing
    K Muller
    Institut fur Medizinische Virologie, Universitat Heidelberg, Federal Republic of Germany
    Virus Genes 18:243-64. 1999
    ..In addition, four putative gene products were found to be significantly homologous to previously identified hypothetical proteins of CIV...
  31. ncbi Onco-suppressor genes in human cancer
    G Della Porta
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Tumori 75:329-36. 1989
    ..abstract truncated at 400 words)..
  32. ncbi Development of a recombinant interleukin-4-Pseudomonas exotoxin for therapy of glioblastoma
    R K Puri
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Toxicol Pathol 27:53-7. 1999
    ..Intratumor administration of IL4-PE has been initiated for the treatment of malignant astrocytoma in a phase I clinical trial...
  33. ncbi Temperature, eluent flow-rate and column effects on the retention and quantitation properties of phenylthiocarbamyl derivatives of amino acids in reversed-phase high-performance liquid chromatography
    A Vasanits
    Institute of Inorganic and Analytical Chemistry, , Budapest, Hungary
    J Chromatogr A 832:109-22. 1999
    ..The utility of the protocol was shown in the quantitation of the free amino acid content of three apple varieties...
  34. ncbi Prescription of statins: cost implications of evidence-based treatment applied to a health authority population
    N Bradshaw
    Gwent Health Authority, Pontypool and Welsh School of Pharmacy, University of Wales, Cardiff, UK
    J Clin Pharm Ther 22:379-89. 1997
    ..It is proposed that statin treatment will have to be prioritized for those at highest risk, whilst maintaining a population-based strategy of promoting lifestyle advice to reduce the risk of cardiovascular events...
  35. ncbi Choline Acetyltransferase from the electric organ of Electrophorus electricus (L.)--physicochemical characterization and immunochemical identification
    N N Tavares
    , , Universidade Federal do Rio de Janeiro, Brasil
    Z Naturforsch C 53:407-15. 1998
    ..Employing an antibody, the presence of ChAT was confirmed with the Western blotting technique. Isoelectrofocusing analysis demonstrated two isoforms with pI of 6,49 and 6,56, respectively...
  36. ncbi Modulating effects of sensory and autonomic neuropeptides on murine splenocyte proliferation and cytokine secretion induced by Leishmania major
    A A Ahmed
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 21:507-26. 1999
    ..These findings indicate that the nervous system, represented by sensory and autonomic nerve terminals and their content of neuromediators, may be involved in the pathophysiology of cutaneous leishmaniasis...
  37. ncbi Health care utilization as a marker for suicidal behavior on an American Indian Reservation
    C N Mock
    Harborview Injury Prevention and Research Center, Seattle, WA 98104
    J Gen Intern Med 11:519-24. 1996
    ..Further research is needed to identify the usefulness of community outreach efforts to identify and intervene among individuals at high risk of death by suicide...
  38. pmc Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3
    L S Kean
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Cell Biol 138:255-70. 1997
    ..These data demonstrated that PDR1 and PDR3 regulate the net rate of M-C6-NBD-PE translocation (flip-flop) and the steady-state distribution of endogenous phosphatidylethanolamine across the plasma membrane...
  39. ncbi The long-term effects of physical loading and exercise lifestyles on back-related symptoms, disability, and spinal pathology among men
    T Videman
    , Finland
    Spine (Phila Pa 1976) 20:699-709. 1995
    ..No benefits were shown for vigorous exercise compared with lighter exercise with respect to back findings...
  40. ncbi Epidemiological identification of Chinese individuals putatively susceptible or insusceptible to Schistosoma japonicum: a prelude to immunogenetic study of human resistance to Asian schistosomiasis
    A G Ross
    Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia
    Ann Trop Med Parasitol 92:765-74. 1998
  41. ncbi Identification of functional domains in the Sep1 protein (= Kem1, Xrn1), which is required for transition through meiotic prophase in Saccharomyces cerevisiae
    V I Bashkirov
    Institute of General Microbiology, University of Bern, Baltzer Strasse 4, CH 3012 Bern, Switzerland
    Chromosoma 104:215-22. 1995
    ..We discuss the potential cellular roles of the Sep1 protein as a microtubule-nucleic acid interface protein linking its suspected function in the microtubular cytoskeleton with its role as a nucleic acid binding protein...
  42. pmc Identification of renal natriuretic peptide receptor subpopulations by use of the non-peptide antagonist, HS-142-1
    R A Rutherford
    Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Br J Pharmacol 113:931-9. 1994
    ..HS-142-1 may be a valuable tool in further elucidating the localization and function of these receptors, but heterogeneity between species should be considered when selecting experimental models...
  43. ncbi Identification of clinical and environmental isolates of Legionella pneumophila by analysis of outer-membrane proteins, ubiquinones and fatty acids
    W Ehret
    Max v Pettenkofer Institute for Hygiene and Medical Microbiology,
    Zentralbl Bakteriol Mikrobiol Hyg A 266:261-75. 1987
    ..pneumophila. The biochemical analyses presented here can supplement immunological studies, clarify immunological findings and help to identify new serogroups of L. pneumophila...
  44. ncbi Quantitation of urinary nucleosides by high-performance liquid chromatography
    H M Liebich
    , , Germany
    J Chromatogr A 763:193-7. 1997
    ..e. breast and floor of mouth tumours, showed some abnormal levels of ribonucleosides. Further experiments are now in progress to measure the modified nucleosides in urine of patients with different forms of cancer...
  45. ncbi A comparison between methods of identification and serotyping of encapsulated strains of Haemophilus influenzae
    I S Taubitz

    Zentralbl Bakteriol Mikrobiol Hyg A 270:83-97. 1988
    ..Rapid identification of at least H. influenzae type b could render treatment in some cases more effective by early application of a suitable antibiotic...
  46. ncbi Cutaneous leishmaniasis in Jordan: biochemical identification of human and Psammomys obesus isolates as Leishmania major
    E K Saliba
    Department of Biological Sciences, University of Jordan, Amman
    Ann Trop Med Parasitol 82:21-5. 1988
    ..m. mexicana. All seven Jordan isolates showed enzyme electromorphs identical to L. major, confirming our ecological/epidemiological studies that P. obesus is a major reservoir for human cutaneous leishmaniasis in Jordan...
  47. ncbi Identification and quantitation of cysteine in proteins separated by gel electrophoresis
    J X Yan
    Macquarie University Centre for Analytical Biotechnology, School of Biological Sciences, Macquarie University, Sydney, NSW, Australia
    J Chromatogr A 813:187-200. 1998
    ..Lysine alkylation with iodoacetamide and acrylamide has also been characterised. Protein identification using amino acid composition including Cys has been introduced...
  48. ncbi Screening and identification of drugs in human hair by high-performance liquid chromatography-photodiode-array UV detection and gas chromatography-mass spectrometry after solid-phase extraction. A powerful tool in forensic medicine
    Y Gaillard
    Laboratoire d'Expertises TOXLAB, Paris, France
    J Chromatogr A 762:251-67. 1997
    ..By establishing a victim's drug use history, it is a very powerful tool in forensic medicine. We illustrate the method with some real cases of police crime investigation...
  49. ncbi Identification of an Spc110p-related protein in vertebrates
    A M Tassin
    Institut Curie, Section Recherche, UMR 144 du CNRS, Paris, France
    J Cell Sci 110:2533-45. 1997
    ..Altogether, these results suggest the existence of an yeast Spc110-related protein in vertebrate centrosomes which is involved in microtubule nucleation...
  50. ncbi [Serotype determination of enteroviruses that cause hand-foot-mouth disease; identification of enterovirus 71 and coxsackievirus A16 from clinical specimens by using specific probe]
    A Kitamura
    Mitsubishi Kagaku Bio-Clinical Laboratories, Inc, Tokyo, Japan
    Kansenshogaku Zasshi 71:715-23. 1997
    ..0%) and 13 (86.7%) specimens were clearly identified, indicating that the method described here offer advantages over the traditional neutralization assay: It is rapid, specific and less labor-consuming...
  51. ncbi [Immediate delayed coronary angioplasty after intravenous thrombolysis in myocardial infarction. Prospective study]
    J L Bonnet
    Service de cardiologie A, CHU Timone, Marseille
    Arch Mal Coeur Vaiss 83:1375-9. 1990
    ..A therapeutic success was obtained in 22 of the 25 patients in Group A, and 19 of the 25 patients in Group B.(ABSTRACT TRUNCATED AT 250 WORDS)..
  52. pmc Identification of both NK1 and NK2 receptors in guinea-pig airways
    K T McKee
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire, Dorval, , Canada
    Br J Pharmacol 110:693-700. 1993
    ..6. In summary, these data demonstrate that guinea-pig lung parenchyma and guinea-pig trachea express both NK1 and NK2 receptors...
  53. ncbi Technetium bone scanning in the diagnosis of osteomyelitis: a meta-analysis of test performance. Diagnostic Technology Assessment Consortium
    B Littenberg
    Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire
    J Gen Intern Med 7:158-64. 1992
    ..In many clinical situations, the specificity of the bone scan will not be high enough to confirm the diagnosis of osteomyelitis...
  54. ncbi Identification of anaerobic bacteria using high-performance liquid chromatography
    R Krausse
    Dept of Medical Microbiology, Univ of Kiel, Federal Republic of Germany
    Zentralbl Bakteriol Mikrobiol Hyg A 265:340-52. 1987
    ..The aim of the method developed is to establish a complete automatization for the identification of anaerobic bacteria using an automatic sampling system and a microprocessor-controlled chromatography unit...
  55. ncbi [Relation of an increase of von Willebrand factor in the blood, acute myocardial infarction, unstable angina and coronary thrombosis]
    J M Mossard
    Service de cardiologie, , CHU de Strasbourg
    Arch Mal Coeur Vaiss 82:1813-8. 1989
    ..In conclusion, the VWF may be considered to be a marker for thrombus and/or endothelial activation but a larger study population would be required to identify more accurately the subgroups with thrombosis or risk of thrombosis...
  56. ncbi [A study on identification method of coxsackie virus A16 and enterovirus 71]
    M Shinohara
    Saitama Institute of Public Health
    Kansenshogaku Zasshi 73:749-57. 1999
    ..And Eco T22 I digestion pattern is only one. These results were in accord with Taq I and EcoT22 I digestion sites on sequences of CA16 and Ev71. This method should be useful for the rapid identification of CA16 and Ev71...
  57. pmc Identification of a novel calcium antagonist binding site in rat brain by SR 33557
    B A Kenny
    Department of Pharmacology, Syntex Research Centre, Riccarton, Edinburgh
    Br J Pharmacol 108:93-9. 1993
    ..The coupling between the SR 33557 and DHP site appears to be very close, resulting in apparently competitive interactions in some experimental protocols but can be revealed as negatively allosteric in other circumstances...
  58. ncbi Identification of protein kinase C isoenzymes in smooth muscle: partial purification and characterization of chicken gizzard PKC zeta
    O Clément-Chomienne
    Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, AB, Canada
    Biochem Cell Biol 74:51-65. 1996
    ..Chicken gizzard PKC zeta was insensitive to the PKC activator phorbol 12,13-dibutyrate or the PKC inhibitor chelerythrine. The properties of PKC zeta are, therefore, quite distinct from those of other well-characterized PKC isoenzymes...
  59. ncbi [Identification of subjects at high risk of coronary disease in a working population using a prediction model]
    D Laurier
    , INSERM U263,
    Arch Mal Coeur Vaiss 88:1569-75. 1995
    ..This multifactorial model is particularly useful for detecting subjects with several borderline factors none of which overstep the usually accepted limits...
  60. ncbi Identification of peroxisomal membrane ghosts with an epitope-tagged integral membrane protein in yeast mutants lacking peroxisomes
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029, USA
    Yeast 11:1045-60. 1995
    ..Gold-labelled membranes were clearly visible in both mutants: in peb2 the labelled membrane vesicles were generally much smaller than those in peb4, which resembled normal peroxisomes in size...
  61. pmc Effectiveness of a skin cancer control educational intervention for internal medicine housestaff and attending physicians
    N C Dolan
    Division of Internal Medicine, Northwestern University Medical School, Chicago, Ill 60611, USA
    J Gen Intern Med 12:531-6. 1997
    ..A more intensive intervention with greater participation may be necessary to show a stronger impact on attitudes and knowledge about skin cancer control among primary care physicians...
  62. pmc Fourier transform infrared spectroscopy for rapid identification of nonfermenting gram-negative bacteria isolated from sputum samples from cystic fibrosis patients
    Alejandra Bosch
    CINDEFI, CONICET, Facultad de Ciencias Exactas, UNLP, 50 entre 115 y 116, La Plata 1900, Argentina
    J Clin Microbiol 46:2535-46. 2008
    ..8%. Our results demonstrate the high degree of reliability and strong potential of ANN-based FTIR spectrum analysis for the rapid identification of NF rods suitable for use in routine clinical microbiology laboratories...
  63. ncbi Using countertransference: analytic contact, projective identification, and transference phantasy states
    Robert Waska
    Am J Psychother 62:333-51. 2008
    ..Then, the patient may use it to build greater psychological freedom, emotional stability, and personal choice...
  64. ncbi Regulatory motif finding by logic regression
    Sunduz Keles
    Division of Biostatistics, University of California, Berkeley, CA 94720, USA
    Bioinformatics 20:2799-811. 2004
  65. ncbi Fluorescence in situ hybridization: a highly efficient technique of molecular diagnosis and predication for disease course in patients with myeloid leukemias
    P S Amare
    Cytogenetics Laboratory, Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai 400012, India
    Cancer Genet Cytogenet 131:125-34. 2001
  66. ncbi Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues
    D N Petersen
    Department of Molecular Sciences and Osteoporosis Group, Pfizer Central Research, Groton, Connecticut 06340, USA
    Endocrinology 139:1082-92. 1998
    ..We propose that ER beta2 should also be considered in addition to ER beta1 and ER alpha when describing the effects of estrogen, estrogen agonists/antagonists, or environmental estrogens...
  67. ncbi Effect-directed analysis of key toxicants in European river basins a review
    Werner Brack
    UFZ Centre for Environmental Research, Department of Effect Directed Analysis, Leipzig, Germany
    Environ Sci Pollut Res Int 14:30-8. 2007
    ..Thus, one focus of present European research is on toxicant identification in European river basins in order to allow for a reduction of toxic pressure on aquatic ecosystems according to the WFD...
  68. ncbi Projected cost-effectiveness of statewide universal newborn hearing screening
    Ron Keren
    Department of Medicine, Children s Hospital, Boston, Massachusetts, USA
    Pediatrics 110:855-64. 2002
  69. ncbi Evaluation of six commercial identification kits for the identification of Staphylococcus aureus isolated from bovine mastitis
    M Zschock
    Public Investigation Office Hesse, Department of Veterinary Medicine, Giessen, Germany
    J Appl Microbiol 98:450-5. 2005
    ..Comparison of six commercially available in human medicine well-established slide agglutination systems for the identification of Staphylococcus aureus...
  70. ncbi Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome
    Qingsong Zhu
    Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA
    Bioinformatics 20:161-9. 2004
    ..We are, therefore, interested in studying the functional genomics of chitinase-like gene families in insects...
  71. ncbi The classification and identification of human somatic and parasympathetic nerve fibres including urinary bladder afferents and efferents is preserved following spinal cord injury
    G Schalow
    Electromyogr Clin Neurophysiol 49:263-86. 2009
    ..Two reasons are brought forward for a too small storage volume of the urinary bladder in paraplegics: too high afferent activity of the bladder due to changed receptor field transduction mechanisms and too low compliance...
  72. pmc Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis
    Genoveva Berná
    Department of Stem Cells, Andalusian Center of Molecular Biology and Regenerative Medicine, University Pablo Olavide CABIMER UPO, Seville 41091, Spain
    Nutrients 6:5338-69. 2014
  73. ncbi Separation and identification of photosynthetic antenna membrane proteins by high- performance liquid chromatography electrospray ionization mass spectrometry
    Lello Zolla
    Department of Environmental Sciences, University of Tuscia, 01100 Viterbo, Italy
    Eur J Mass Spectrom (Chichester) 10:321-33. 2004
  74. pmc Microbial identification by mass cataloging
    Zhengdong Zhang
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Avenue, Houston, TX 77204 5001, USA
    BMC Bioinformatics 7:117. 2006
    ..Alternatively, if the organism is not in the existing database, it will still be possible to determine its genetic affinity relative to the known organisms...
  75. pmc Detection of campylobacter species: a comparison of culture and polymerase chain reaction based methods
    S P Kulkarni
    Public Health Laboratory, Central Middlesex Hospital, Acton Lane, Park Royal, London NW10 7NS, UK
    J Clin Pathol 55:749-53. 2002
    ..To investigate the optimal method for the detection of campylobacters from stool samples by comparing selective culture with membrane filtration and the polymerase chain reaction (PCR)...
  76. doi Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1
    Albert P Li
    Advanced Pharmaceutical Sciences, Inc and In Vitro ADMET Laboratories LLC, Columbia, MD 21045, USA
    Chem Biol Interact 179:4-8. 2009
    ..This proof-of-concept study suggests that MCCA and CMPIA with cryopreserved human hepatocytes are potentially useful for the evaluation of the relationship between human xenobiotic metabolism and toxicity...
  77. doi Effects of hearing loss and spectral shaping on identification and neural response patterns of stop-consonant stimuli in young adults
    Ashley W Harkrider
    Department of Audiology and Speech Pathology, University of Tennessee, Knoxville, TN 37920, USA
    Ear Hear 30:31-42. 2009
  78. ncbi A biomimetic approach to the detection and identification of estrogen receptor agonists in surface waters using semipermeable membrane devices (SPMDs) and bioassay-directed chemical analysis
    Andrew C Rastall
    Institute of Hygiene and Medical Microbiology, University of Heidelberg, Germany
    Environ Sci Pollut Res Int 13:256-67. 2006
  79. ncbi [DNA extraction and identification of Trichophyton rubrum by real-time polymerase chain reaction from direct nail scraping specimens of patients with onycomycosis]
    Elife Berk
    Kayseri Research and Training Hospital, Microbiology Clinics, Kayseri, Turkey
    Mikrobiyol Bul 45:150-8. 2011
  80. ncbi Rapid and sensitive identification of major histocompatibility complex class I-associated tumor peptides by Nano-LC MALDI MS/MS
    Sandra Hofmann
    Institute for Pharmaceutical Chemistry Center for Drug Research, Development and Safety ZAFES, Biocenter, Johann Wolfgang Goethe University of Frankfurt, Marie Curie Str 9, 60439 Frankfurt Main, Germany
    Mol Cell Proteomics 4:1888-97. 2005
    ..We conclude that the nano-LC MALDI MS/MS approach is a sensitive tool for the rapid and automated identification of MHC-associated tumor peptides...
  81. ncbi Discriminating toxicant classes by mode of action. 1. (Eco)toxicity profiles
    Monika Nendza
    Analytisches Laboratorium, Luhnstedt, Germany
    Environ Sci Pollut Res Int 13:192-203. 2006
    ..identification of chemicals with specific MOAs, (4.) indication of most sensitive species, (5.) identification of chemicals that are outliers in QSARs and (6.) selection of appropriate QSARs for predictions...
  82. ncbi [Future prospects of molecular epidemiology in tuberculosis]
    Tomoshige Matsumoto
    Osaka Prefectural Hospital Organization Osaka Prefectural Medical Center for Respiratory and Allergic Diseases
    Kekkaku 84:783-4. 2009
    ..By introducing VNTR to clinical practice, we can diminish days of inappropriate hospitalization. Because VNTR data are numerical, we can easily construct VNTR database, compare data, and survey emergence of MDR/XDR-tuberculosis...
  83. ncbi Species identification and strain differentiation of clinical Candida isolates using the DiversiLab system of automated repetitive sequence-based PCR
    Mark G Wise
    Bacterial Barcodes Inc, Athens, GA 30602, USA
    J Med Microbiol 56:778-87. 2007
    ..This system may also be useful for epidemiological studies such as source tracking that require Candida subspecies discrimination...
  84. ncbi Rapid identification of non-sporing anaerobes using nuclear magnetic resonance spectroscopy and an identification strategy
    S Menon
    Department of Microbiology, Grant Medical College and Sir J J Hospital, Mumbai 400 008, Maharashatra, India
    Indian J Med Microbiol 25:330-5. 2007
  85. pmc Enhanced detection method for corneal protein identification using shotgun proteomics
    Mitchell L Meade
    Applied Biotechnology Branch, Biosciences and Protection Division, Wright Patterson AFB, Ohio, USA
    Proteome Sci 7:23. 2009
  86. pmc Automated de-identification of free-text medical records
    Ishna Neamatullah
    Laboratory for Computational Physiology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    BMC Med Inform Decis Mak 8:32. 2008
    ..Manual de-identification of large medical record databases is prohibitively expensive, time-consuming and prone to error, necessitating automatic methods for large-scale, automated de-identification...
  87. doi Identification and quantification of phenolic compounds in grapes by HPLC-PDA-ESI-MS on a semimicro separation scale
    Isabella Nicoletti
    Istituto di Metodologie Chimiche CNR, Area della Ricerca di Roma 1, Via Salaria km 29 300, Montelibretti, P O Box 10, 00016 Monterotondo Stazione, Rome, Italy
    J Agric Food Chem 56:8801-8. 2008
    ..In almost all samples, the most and least abundant anthocyanins were malvidin 3-O-glucoside and cyanidin 3-O-glucoside, respectively, with the exception of Uva di Troia where the least abundant anthocyanin was delphinidin 3-O-glucoside...
  88. pmc Accuracy of six commercially available systems for identification of members of the family vibrionaceae
    Caroline M O'Hara
    Division of Healthcare Quality Promotion, Epidemiology and Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:5654-9. 2003
    ..parahaemolyticus strains. Thus, extreme care must be taken in the interpretation of answers from these six commercially available systems for the identification of Vibrio species...
  89. ncbi Recurrent laryngeal nerve identification and assessment during thyroid surgery: laryngeal palpation
    Gregory W Randolph
    Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
    World J Surg 28:755-60. 2004
    ..We believe that laryngeal palpation is useful as an adjunct to formal EMG monitoring during thyroid and parathyroid surgery...
  90. ncbi In vivo identification of sentinel lymph nodes for clinical stage I non-small cell lung cancer for abbreviation of mediastinal lymph node dissection
    Hiroaki Nomori
    Department of Thoracic Surgery, Saiseikai Central Hospital, 1 4 17 Mita, Minato ku, Tokyo 108 0073, Japan
    Lung Cancer 46:49-55. 2004
  91. ncbi Identification of coagulase-negative staphylococci other than Staphylococcus epidermidis by automated ribotyping
    E Carretto
    Laboratori Sperimentali di Ricerca, Area Infettivologica, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Clin Microbiol Infect 11:177-84. 2005
    ..caprae, Staphylococcus warneri, Staphylococcus lugdunensis, Staphylococcus schleiferi, Staphylococcus sciuri, Staphylococcus pasteuri and Staphylococcus xylosus...
  92. doi Is post-mortem CT of the dentition adequate for correct forensic identification?: comparison of dental computed tomograpy and visual dental record
    S Kirchhoff
    Institute of Clinical Radiology, University Hospital Munich Grosshadern Innenstadt, Ziemssenstrasse 1, 80336, Munich, Germany
    Int J Legal Med 122:471-9. 2008
    ..Thus, PMCT should only be performed for identification in individual cases due to the relatively high error rate...
  93. ncbi Approaches to the identification and recording of nasal lesions in toxicology studies
    K T Morgan
    CIIT, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 19:337-51. 1991
    ..A systematic but flexible approach is recommended...
  94. pmc Detection and identification by PCR of Clostridium chauvoei in clinical isolates, bovine faeces and substrates from biogas plant
    E Bagge
    Department of Bacteriology, National Veterinary Institute, Uppsala, Sweden
    Acta Vet Scand 51:8. 2009
    ..chauvoei. Therefore, detection by PCR is would be useful. This study applied a PCR-based method to detect of C. chauvoei in 25 muscle and blood samples, 114 manure samples, 84 soil samples and 33 samples from the biogas process...
  95. doi Discrimination of Culicoides obsoletus and Culicoides scoticus, potential bluetongue vectors, by morphometrical and mitochondrial cytochrome oxidase subunit I analysis
    D Augot
    USC VECPAR, AFSSA LERPAZ, JE2533, Universite de Reims Champagne Ardenne, UFR Pharmacie, 51 rue Cognacq Jay, 51100 Reims, France
    Infect Genet Evol 10:629-37. 2010
    ..This approach should improve the accuracy of morphologically-based species identification...
  96. pmc Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia
    Pavel Drevinek
    Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3TL, UK
    BMC Microbiol 8:44. 2008
  97. pmc Rapid identification of methicillin-resistant staphylococci bacteremia among intensive care unit patients
    Manal Diab
    Medical Microbiology and Immunology, Cairo University, Guiza, Egypt
    Medscape J Med 10:126. 2008
    ..Therefore, it is recommended to use the method with high sensitivity and the shortest TAT...
  98. pmc Species-specific identification of a wide range of clinically relevant fungal pathogens by use of Luminex xMAP technology
    C Landlinger
    Division of Molecular Microbiology and Development of Genetic Diagnostics, Children s Cancer Research Institute, Vienna, Austria
    J Clin Microbiol 47:1063-73. 2009
    ..Our observations demonstrate that the Luminex-based technology presented permits rapid and reliable identification of fungal species and may therefore be instrumental in routine clinical diagnostics...
  99. ncbi Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing
    V Thybaud
    Drug Safety Evaluation, Sanofi Aventis, 94400 Vitry sur Seine, France
    Mutat Res 627:41-58. 2007
    ..Although general principles were agreed upon, time did not permit the development of recommendations for the selection of specific tests beyond those commonly employed in initial test batteries...
  100. pmc Identification of coryneform bacterial isolates by ribosomal DNA sequence analysis
    Y W Tang
    Departments of Medicine and Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Microbiol 38:1676-8. 2000
    ..5 to 18.5 h. These data demonstrate that the MicroSeq 500 16S bacterial sequencing kit provides a potentially powerful method for the definitive identification of clinical coryneform bacterium isolates...
  101. ncbi Music perception with temporal cues in acoustic and electric hearing
    Ying Yee Kong
    Department of Cognitive Sciences, University of California, Irvine, 92697, USA
    Ear Hear 25:173-85. 2004
    ..The second aim is to identify the relative contribution of temporal and spectral cues to melody recognition in acoustic and electric hearing...

Research Grants81

    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  5. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  6. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  7. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  8. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..The contractor is responsible for providing staff with the credentials required by CLIA. ..
  9. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
  10. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..We therefore believe the proposed work has the potential to have a significant impact on the health care of Veterans. ..
  11. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
  12. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
  13. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
  14. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..The outcome of this project will be the initial characterization of a valuable therapeutic option for treatment of patients with various types of skin wounds. ..
  15. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..This would set the stage for a final lead optimization campaign focused on identifying pre- clinical leads with well-balanced in vivo PK parameters during an SBIR Phase 2 continuing grant. ..
  16. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..abstract_text> ..
  17. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..abstract_text> ..
  18. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..The chemical probes designed, synthesized and validated in this proposal will have applications in the discovery of molecular targets to treat diseases such as cancer and in the development of safe stem cell based therapeutics. ..
  19. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Results of this proposed research will provide fundamental information that may lead to better prevention and/or therapeutics for diabetes and cardiovascular disease in humans. ..
  20. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans. ..
    Enrique A Mesri; Fiscal Year: 2013
    ..So our work will allow us to not only to identify mechanisms of KS carcinogenesis but also will help to identify potential new target and new drugs for anti-KS therapy. ..
  22. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    ..The studies would also lead to the identification of biomarkers that would be useful in clinical trials. ..
  23. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..Thus, our research plan has potentially broad translational significance. ..
  24. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
  25. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..The results of this study will aid in the development of evidence-based guidelines for the treatment of Alaska Native infants diagnosed with CPT1A deficiency by newborn screening. ..
  26. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
  27. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..These studies are relevant to other vascular diseases including stroke, diabetes, and chronic renal insufficiency, which are also common among veterans. ..
  28. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    ..abstract_text> ..
  29. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    David Allen; Fiscal Year: 2009
    ..NICEATM and ICCVAM will also evaluate non-animal methods and approaches for determining the skin irritation potential of antimicrobial cleaning products...
  31. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..Understanding how these proteins work together will help to design new therapeutic approaches and possibly drugs for treatment of different human diseases and breast cancer. ..
    Sarah Wagner; Fiscal Year: 2013
    ..This research will identify and analyze these issues and challenges, and inform the development of concrete policy recommendations by relevant stakeholders. ..
  33. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..The proposed experiments will provide essential mechanistic insight into the previously observed radio-protective and -mitigative effects of CBLB502. ..
    Pi Wan Cheng; Fiscal Year: 2010
    ..Current studies could facilitate the development of therapy for mucus hypersecretory diseases through identification of small carbohydrate inhibitors and mucus cell-specific promoter. ..
  35. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..Furthermore, the accompanying mentoring and course work will prepare Dr. Assassi to become an independent and productive clinician scientist and a leader in rigorously designed and conducted translational research in rheumatic diseases. ..
  36. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
  37. Genomics of Antiviral Responses of Anopheles gambiae Against O'nyong-nyong Virus
    Young S Hong; Fiscal Year: 2010
    ..Considering there exist overlapping immune responses against bacterial and malaria infections in An. gambiae, our findings may also provide information applicable to Plasmodium infection. ..
  38. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
  39. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
    ..If successful, this technology can potentially transform the field of live attenuated vaccines for many viral diseases. ..
  40. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
  41. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
  42. Latin American Center for Malaria Research and Control
    ..RELEVANCE: Identify the relationship between environmental factors, parasite characteristics, household conditions and the malaria prevalence related to the epidemiology and clinical findings. ..
  43. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
  44. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
  45. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
  46. Interdisciplinary Research Training in Reproduction for Indian Fellows
    John C Herr; Fiscal Year: 2010
    ..abstract_text> ..
  47. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
  48. Viral and Host Determinants of New World Alphaviral Entry
    ASIM AMINSHARIF AHMED; Fiscal Year: 2013
    ..Children's Hospital Boston is committed to this career development plan and has assured the candidate will be able to devote at least 85% full-time effort to the activities described in this proposal. ..
  49. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..Defining the mechanistic linkage between PUFA synthesis, TAG hydrolysis, FoxO1, GNG &stress pathways will identify novel methods to manage diabetic complications, like hyperglycemia &fatty liver. ..
  50. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..This project will identify potential therapeutic targets and molecules that will provide the basis for future therapies of these chronic lung diseases that, together, comprise a major health problem world-wide. ..
  51. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..Ultimately, Dr. Bhave hopes to translate his seminal biochemical discovery into an independent line of investigation examining the role of peroxidasin in matrix remodeling and expansion in renal disease. ..
  52. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..The long-range goal of our research is to understand the role of -defensins in the innate immune defense against viruses so that novel therapies can be developed from our findings. ..
  53. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..The contributions of alterations in the production of gastrointestinal and adipocyte hormones, changes of bile acids and intestinal microbial composition, as well as mitochondrial function will be assessed. ..
    Alvaro Puga; Fiscal Year: 2013
    Rafi Ahmed; Fiscal Year: 2013
  56. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..This project aims to identify proteins that are important to male osteoporosis. The findings will provide essential scientific basis for effective prevention, diagnosis and treatment of the disease. ..
  57. Cerebral metabolism, EEG, and sleep cycling in critically ill neonates
    Renée A Shellhaas; Fiscal Year: 2013
    ..abstract_text> ..
  58. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
    ..Studying the untoward effects of mutant ET genes will increase our knowledge of ET and other movement disorders such as Parkinson disease. ..
  59. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    ..These studies may lead to the development of new drugs and/or dietary components for use in cancer prevention or treatment. ..
  60. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
  61. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    ..Also, this study has potential impact on the identification and development of novel therapeutic targets for effective treatment of NAFLD and other related metabolic diseases. ..
  62. Genetics of the Neuromuscular Junction: Mechanisms and Disease Models
    Robert W Burgess; Fiscal Year: 2013
  63. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..We will explore the possibility of making this therapy noncellular to avoid complications of cell therapy. This research is of high significance for development of improved therapies for female pelvic floor disorders. ..
  64. Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammals
    Rochelle W Tyl; Fiscal Year: 2009
    ..N-dimethylacetoacetamide were completed during this reporting period and final reports are being prepared. ..
  65. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
  66. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
    ..abstract_text> ..
  67. Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP Synthase
    Zulfiqar Ahmad; Fiscal Year: 2009
    ..Intact F1Fo and soluble F1ATPase can be obtained in pure form. F1-ATPase yield is high and the enzyme can be stored in -70 oC for a long period of time with excellent retention of ATPase activity. ..
  68. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
  69. Mutational Cloning in Familial Dementia and Alzheimers Disease
    Wendy H Raskind; Fiscal Year: 2010
    ..We will employ newly available powerful sequencing and bioinformatics techniques to detect causative mutations in families with apparent autosomal dominant dementia where the available affected persons are too few for linkage analyses. ..
    James Slama; Fiscal Year: 1991
    ..The "transition-state analogue" will be tested as an inhibitor of NAD- glycohydrolase and the microbial toxins...
  71. Proteomic Identification of Actionable Biomarkers in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2010
    ..6% of the world population. This proposal will identify novel autoantibody and cytokine biomarkers for (i) early diagnosis, (ii) predicting disease severity, and (iii) guiding therapeutic decision making for the treatment of RA. ..
  72. Culture and Identification of Rickettsia-like Organisms in Maryland
    Douglas E Norris; Fiscal Year: 2010
    ..Additionally, we will utilize the genetic material recovered via culture, to develop, optimize and utilize molecular methods to characterize these novel organisms that have eluded identification with existing tools. ..
  73. A novel assay for inhibitors of influenza A virus polymerase complex assembly
    Feng Li; Fiscal Year: 2009
    ..Successful completion of the proposed research will help identify and design additional anti-influenza inhibitors that will provide additional treatment options and improve disease outcome. ..
  74. Identification of Novel Alpha Amidated Peptide Hormones
    ANGELO CONSALVO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  75. Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
    Hilary P Blumberg; Fiscal Year: 2010
  76. Risk of Cancer with Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..The goal is to develop management strategies for these incidental findings that will maximize the detection of occult cancer, while minimizing unnecessary imaging surveillance. ..
  77. Arrayed Lateral Flow Biosensor for Rapid Molecular Identification of UTI-Related
    Anjal C Sharma; Fiscal Year: 2012
    ..Having the information on the identity of the pathogen(s) involved also allows physicians to better prescribe antibiotics without contributing to growing antimicrobial resistance. ..
  78. LTQ Orbitrap XL ETD Mass Spectrometer
    Haining Zhu; Fiscal Year: 2010
    ..The requested instruments are environmentally friendly. In summary, the funding of this application will make the United States and the world healthier, cleaner and safer. ..
    Deborah Redford Badwal; Fiscal Year: 1993
    ..The strategy should be applicable to defining mutations of any gene that is expressed in cartilage and provide an avenue for understanding the molecular basis of this extremely heterogeneous group of heritable disorders...
  80. DNA-modulated release of drug from melanoma targeting NP
    Kit Lam; Fiscal Year: 2009
    ..In this R21 application we shall develop this novel nanotherapeutic approach in a melanoma xenograft model. ..
  81. Technology for automated real-time counting and identification of adult mosquitoe
    PHILIPP KIRSCH; Fiscal Year: 2007
    ..Public health vector control specialists are very supportive of the proposed work plan and technology. [unreadable] [unreadable] [unreadable]..