Summary: The processes whereby the internal environment of an organism tends to remain balanced and stable.

Top Publications

  1. ncbi Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Science 306:2090-3. 2004
  2. ncbi Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    D R Matthews
    Diabetologia 28:412-9. 1985
  3. pmc Hepcidin and iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1823:1434-43. 2012
  4. pmc Macrophage biology in development, homeostasis and disease
    Thomas A Wynn
    Immunopathogenesis Section, Program in Tissue Immunity and Repair and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20877 8003, USA
    Nature 496:445-55. 2013
  5. pmc Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    Paul D Ray
    Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, NC 27695 7633, USA
    Cell Signal 24:981-90. 2012
  6. ncbi Regulation of cell death: the calcium-apoptosis link
    Sten Orrenius
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
    Nat Rev Mol Cell Biol 4:552-65. 2003
  7. pmc Adipocytes as regulators of energy balance and glucose homeostasis
    Evan D Rosen
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 444:847-53. 2006
  8. pmc Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Science 313:1137-40. 2006
  9. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
  10. ncbi ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
    Michel B Toledano
    CEA, iBiTecS, SBIGeM, Laboratoire Stress Oxydants et Cancer, Batiment 142, Commissariat à l Energie Atomique Saclay, 91191 Gif sur Yvette, France
    Nat Rev Mol Cell Biol 8:813-24. 2007

Detail Information

Publications329 found, 100 shown here

  1. ncbi Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Science 306:2090-3. 2004
    ..The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface...
  2. ncbi Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    D R Matthews
    Diabetologia 28:412-9. 1985
    ..of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA)...
  3. pmc Hepcidin and iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1823:1434-43. 2012
    ..Hepcidin, ferroportin and their regulators represent potential targets for the diagnosis and treatment of iron disorders and anemias. This article is part of a Special Issue entitled: Cell Biology of Metals...
  4. pmc Macrophage biology in development, homeostasis and disease
    Thomas A Wynn
    Immunopathogenesis Section, Program in Tissue Immunity and Repair and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20877 8003, USA
    Nature 496:445-55. 2013
    ..They have roles in development, homeostasis, tissue repair and immunity...
  5. pmc Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    Paul D Ray
    Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, NC 27695 7633, USA
    Cell Signal 24:981-90. 2012
    ..such as proliferation and survival (MAP kinases, PI3 kinase, PTEN, and protein tyrosine phosphatases), ROS homeostasis and antioxidant gene regulation (thioredoxin, peroxiredoxin, Ref-1, and Nrf-2), mitochondrial oxidative stress, ..
  6. ncbi Regulation of cell death: the calcium-apoptosis link
    Sten Orrenius
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
    Nat Rev Mol Cell Biol 4:552-65. 2003
    ..However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death...
  7. pmc Adipocytes as regulators of energy balance and glucose homeostasis
    Evan D Rosen
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 444:847-53. 2006
    ..Adipose tissue also serves as a crucial integrator of glucose homeostasis. Knowledge of adipocyte biology is therefore crucial for understanding the pathophysiological basis of obesity ..
  8. pmc Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Science 313:1137-40. 2006
    ..Our results demonstrate that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes...
  9. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha...
  10. ncbi ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
    Michel B Toledano
    CEA, iBiTecS, SBIGeM, Laboratoire Stress Oxydants et Cancer, Batiment 142, Commissariat à l Energie Atomique Saclay, 91191 Gif sur Yvette, France
    Nat Rev Mol Cell Biol 8:813-24. 2007
    ..The pathways that regulate ROS homeostasis are crucial for mitigating the toxicity of ROS and provide strong evidence about specificity in ROS signalling...
  11. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
    ..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases.
  12. ncbi Tensional homeostasis and the malignant phenotype
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 8:241-54. 2005
    ..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...
  13. pmc Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    Simon Yona
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 38:79-91. 2013
  14. doi Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    Tomoki Nakashima
    Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    Nat Med 17:1231-4. 2011
    Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts...
  15. ncbi Sleep function and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Sleep Med Rev 10:49-62. 2006
    This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis...
  16. pmc Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    Suneng Fu
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 473:528-31. 2011
    ..synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER homeostasis leads to stress and the activation of the unfolded protein response...
  17. pmc The self-tuning neuron: synaptic scaling of excitatory synapses
    Gina G Turrigiano
    Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Cell 135:422-35. 2008
    ..Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales...
  18. pmc Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
    Congcong He
    Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nature 481:511-5. 2012
    ..Thus, exercise induces autophagy, BCL2 is a crucial regulator of exercise- (and starvation)-induced autophagy in vivo, and autophagy induction may contribute to the beneficial metabolic effects of exercise...
  19. ncbi Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    Peter M Siegel
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Rev Cancer 3:807-21. 2003
  20. ncbi Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabetes Care 23:57-63. 2000
    To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans.
  21. pmc MiR-33 contributes to the regulation of cholesterol homeostasis
    Katey J Rayner
    Department of Medicine, Leon H Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
    Science 328:1570-3. 2010
    ..Conversely, silencing of miR-33 in vivo increases hepatic expression of ABCA1 and plasma HDL levels. Thus, miR-33 appears to regulate both HDL biogenesis in the liver and cellular cholesterol efflux...
  22. pmc Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis
    Shuo Chien Ling
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Neuron 79:416-38. 2013
    ..Dysfunction in RNA processing and protein homeostasis is an emerging theme...
  23. pmc The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    Meghan A Koch
    Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 10:595-602. 2009
    Several subsets of Foxp3(+) regulatory T cells (T(reg) cells) work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure...
  24. ncbi A single type of progenitor cell maintains normal epidermis
    Elizabeth Clayton
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 0XZ, UK
    Nature 446:185-9. 2007
    According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate ..
  25. pmc Homeostasis and inflammation in the intestine
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:859-70. 2010
    ..In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost.
  26. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    ..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
  27. doi Immune adaptations that maintain homeostasis with the intestinal microbiota
    Lora V Hooper
    The Howard Hughes Medical Institute and The Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Nat Rev Immunol 10:159-69. 2010
    ..In this Review, we discuss the unique adaptations of the intestinal immune system that maintain homeostatic interactions with a diverse resident microbiota...
  28. ncbi Translational control is required for the unfolded protein response and in vivo glucose homeostasis
    D Scheuner
    Howard Hughes Medical Institute, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA
    Mol Cell 7:1165-76. 2001
    ..The results demonstrate that regulation of translation through eIF2alpha phosphorylation is essential for the ER stress response and in vivo glucose homeostasis.
  29. pmc Intrinsic noise in gene regulatory networks
    M Thattai
    Department of Physics, Room 13-2010, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 98:8614-9. 2001
    ..The analysis of intrinsic noise reveals biological roles of gene network structures and can lead to a deeper understanding of their evolutionary origin...
  30. doi Autophagy for tissue homeostasis and neuroprotection
    Guillermo Mariño
    INSERM, U848, F 94805 Villejuif, France
    Curr Opin Cell Biol 23:198-206. 2011
    ..been viewed as a cell death mechanism in the mammalian system, it is now considered as indispensable for the homeostasis of cells, tissues, and organisms...
  31. pmc Epidermal homeostasis: a balancing act of stem cells in the skin
    Cedric Blanpain
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, 808, Route de Lennik, 1070 Bruxelles, Belgium
    Nat Rev Mol Cell Biol 10:207-17. 2009
    The skin epidermis and its array of appendages undergo ongoing renewal by a process called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue homeostasis by providing new cells to replace those that are ..
  32. ncbi A central role for JNK in obesity and insulin resistance
    Jiro Hirosumi
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 420:333-6. 2002
    ..Thus, JNK is a crucial mediator of obesity and insulin resistance and a potential target for therapeutics...
  33. pmc MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
    Wei Chih Tsai
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Clin Invest 122:2884-97. 2012
  34. doi Reactive oxygen species homeostasis and signalling during drought and salinity stresses
    Gad Miller
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, 89557, USA
    Plant Cell Environ 33:453-67. 2010
    ..in combination with other stresses, disrupt photosynthesis and increase photorespiration, altering the normal homeostasis of cells and cause an increased production of reactive oxygen species (ROS)...
  35. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity...
  36. ncbi Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
    Science 306:457-61. 2004
    ..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...
  37. pmc Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Science 332:243-7. 2011
    ..Adipose tissue AAMs are necessary to maintain glucose homeostasis and are induced by the cytokine interleukin-4 (IL-4)...
  38. doi Homeostasis of naive and memory T cells
    Charles D Surh
    The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 29:848-62. 2008
    ..Typical memory cells are kept alive and induced to divide intermittently by a mixture of IL-7 and IL-15. This review highlights recent advances in how naive and memory T cell homeostasis is regulated.
  39. ncbi Local sleep and learning
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nature 430:78-81. 2004
    ..It has been suggested that SWA homeostasis may reflect synaptic changes underlying a cellular need for sleep...
  40. pmc The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    Patrick M Smith
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Science 341:569-73. 2013
    ..Our study reveals that a class of abundant microbial metabolites underlies adaptive immune microbiota coadaptation and promotes colonic homeostasis and health.
  41. ncbi Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
    ..In addition, TGF-beta signaling positively regulated T cell development and homeostasis. Development of CD8+ T cells and NKT cells, maintenance of peripheral Foxp3-expressing regulatory T cells, and ..
  42. pmc MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    S Hani Najafi-Shoushtari
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Science 328:1566-9. 2010
    ..Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases.
  43. ncbi Regulation of ion homeostasis under salt stress
    Jian Kang Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Curr Opin Plant Biol 6:441-5. 2003
    ..The protein kinase complex then phosphorylates and activates various ion transporters, such as the plasma membrane Na(+)/H(+) antiporter SOS1...
  44. doi Tgf-beta superfamily signaling in embryonic development and homeostasis
    Mary Y Wu
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 16:329-43. 2009
    ..that these pathways contribute to the increased diversity and complexity required for the development and homeostasis of these organisms...
  45. pmc Redox homeostasis and antioxidant signaling: a metabolic interface between stress perception and physiological responses
    Christine H Foyer
    Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Plant Cell 17:1866-75. 2005
  46. pmc NK cell development, homeostasis and function: parallels with CD8⁺ T cells
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Rev Immunol 11:645-57. 2011
    ..In this Review, we highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8(+) T cell...
  47. pmc LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
    Martin C Herzig
    Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Hum Mol Genet 20:4209-23. 2011
    ..These novel aspects of peripheral LRRK2 biology critically impact ongoing attempts to develop LRRK2 selective kinase inhibitors as therapeutics for PD...
  48. pmc Zinc homeostasis and signaling in health and diseases: Zinc signaling
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230 0045, Japan
    J Biol Inorg Chem 16:1123-34. 2011
    The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory ..
  49. pmc Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
    Jonathan Sprent
    Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Nat Immunol 12:478-84. 2011
    ..The molecular mechanisms that control the conversion of naive resting T cells into memory-phenotype cells TCR-dependent in normal animals are beginning to be understood...
  50. doi Regulation of oxygen homeostasis by hypoxia-inducible factor 1
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA
    Physiology (Bethesda) 24:97-106. 2009
    ..Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease...
  51. pmc Alkali metal cation transport and homeostasis in yeasts
    Joaquin Arino
    Departament de Bioquimica i Biologia Molecular, Ed V, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Microbiol Mol Biol Rev 74:95-120. 2010
    ..Similarly, very little is known about the regulation of organellar transport and homeostasis of alkali metal cations...
  52. doi Intestinal homeostasis and its breakdown in inflammatory bowel disease
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 474:298-306. 2011
    Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system...
  53. doi FOXOs: signalling integrators for homeostasis maintenance
    Astrid Eijkelenboom
    Molecular Cancer Research, Division Biomedical Genetics, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584CG Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 14:83-97. 2013
    ..The diversity of this upstream regulation and the downstream effects of FOXOs suggest that they function as homeostasis regulators to maintain tissue homeostasis over time and coordinate a response to environmental changes, ..
  54. pmc A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Bong Hyun Ahn
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:14447-52. 2008
    ..These results implicate protein acetylation as an important regulator of Complex I activity and demonstrate that Sirt3 functions in vivo to regulate and maintain basal ATP levels...
  55. ncbi A receptor-mediated pathway for cholesterol homeostasis
    M S Brown
    Science 232:34-47. 1986
  56. pmc Unraveling mechanisms of homeostatic synaptic plasticity
    Karine Pozo
    MRC Cell Biology Unit and MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Neuron 66:337-51. 2010
    ..Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity...
  57. doi Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    Anne Wilson
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Cell 135:1118-29. 2008
    ..While they form a silent reservoir of the most potent HSCs during homeostasis, they are efficiently activated to self-renew in response to bone marrow injury or G-CSF stimulation...
  58. pmc FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    Ji Hye Paik
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Cell 128:309-23. 2007
    ..Functional studies validated Sprouty2 and PBX1, among others, as FoxO-regulated mediators of endothelial cell morphogenesis and vascular homeostasis.
  59. pmc The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
    Kai Yang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 12:888-97. 2011
    ..complex mTORC1 but less mTORC2 activity, and activation of mTORC1 was essential for the disruption of immune homeostasis. Therefore, Tsc1-dependent control of mTOR is crucial in actively maintaining the quiescence of naive T cells ..
  60. ncbi Sleep and synaptic homeostasis: a hypothesis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Brain Res Bull 62:143-50. 2003
    ..Synaptic downscaling is tied to the beneficial effects of sleep on performance. The hypothesized link between sleep and synaptic homeostasis is supported by several lines of evidence and leads to testable predictions.
  61. doi Key role for gene dosage and synaptic homeostasis in autism spectrum disorders
    Roberto Toro
    Human Genetics and Cognitive Functions, Institut Pasteur, 75015 Paris, France
    Trends Genet 26:363-72. 2010
    ..Finally, the broad expression and function of the causative genes suggest that alteration of synaptic homeostasis could be a common biological process associated with ASD...
  62. pmc Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
    Thomas R Cox
    Cancer Research UK Tumour Cell Signalling Unit, Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
    Dis Model Mech 4:165-78. 2011
    ..Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound healing and normal organ homeostasis. Life-threatening pathological conditions arise when ECM remodeling becomes excessive or uncontrolled...
  63. doi Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    Djahida Bouskra
    Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961
    Nature 456:507-10. 2008
    Intestinal homeostasis is critical for efficient energy extraction from food and protection from pathogens...
  64. doi Epithelial barriers in homeostasis and disease
    Amanda M Marchiando
    Department of Pathology, Graduate Program in Molecular Pathogenesis and Molecular Medicine, The University of Chicago, Chicago, Illinois, 60637, USA
    Annu Rev Pathol 5:119-44. 2010
    ..In this review, we discuss the critical roles of the tight junction in health and explore the contributions of barrier dysfunction to disease pathogenesis...
  65. pmc AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    Sang Min Jeon
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Nature 485:661-5. 2012
    ..Thus AMPK, in addition to its function in ATP homeostasis, has a key function in NADPH maintenance, which is critical for cancer cell survival under energy stress ..
  66. doi WNT signaling in bone homeostasis and disease: from human mutations to treatments
    Roland Baron
    Department of Medicine, Harvard Medical School, Harvard University, Boston, Massachusetts, USA
    Nat Med 19:179-92. 2013
    ..Mouse genetics confirmed the importance of canonical Wnt signaling in the regulation of bone homeostasis, with activation of the pathway leading to increased, and inhibition leading to decreased, bone mass and ..
  67. pmc Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
    Laurel A Monticelli
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:1045-54. 2011
    ..orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized...
  68. ncbi Identification of a nuclear receptor for bile acids
    M Makishima
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9050, USA
    Science 284:1362-5. 1999
    ..These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport...
  69. doi A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
    Robert J Snelgrove
    Imperial College London, Kennedy Institute, London, W6 8LH, UK
    Nat Immunol 9:1074-83. 2008
    ..Thus, CD200R is critical for lung macrophage immune homeostasis in the resting state and limits inflammatory amplitude and duration during pulmonary influenza infection.
  70. pmc Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
    L D Klaman
    Cancer Biology Program, Division of Hematology Oncology, Boston, Massachusetts 02215, USA
    Mol Cell Biol 20:5479-89. 2000
    ..Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo...
  71. pmc MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake
    Fabiana Perocchi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 467:291-6. 2010
    ..Its discovery may lead to the complete molecular characterization of mitochondrial calcium uptake pathways, and offers genetic strategies for understanding their contribution to normal physiology and disease...
  72. doi Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    Hellmut G Augustin
    Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, University of Heidelberg, and German Cancer Research Center Heidelberg DKFZ ZMBH Alliance, Germany
    Nat Rev Mol Cell Biol 10:165-77. 2009
    ..essential during embryonic vessel assembly and maturation, and functions as a key regulator of adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands ..
  73. pmc Complement: a key system for immune surveillance and homeostasis
    Daniel Ricklin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Nat Immunol 11:785-97. 2010
    ..microbes, orchestrating immune responses and sending 'danger' signals, complement contributes substantially to homeostasis, but it can also take action against healthy cells if not properly controlled...
  74. ncbi Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    Gilles Huberfeld
    INSERM U739, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, IFR70, CHU Pitie Salpetriere, 75013 Paris, France
    J Neurosci 27:9866-73. 2007
    Changes in chloride (Cl-) homeostasis may be involved in the generation of some epileptic activities...
  75. doi The mitochondrial UPR - protecting organelle protein homeostasis
    Cole M Haynes
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 390, New York, NY 10065, USA
    J Cell Sci 123:3849-55. 2010
    ..Here, we review the current knowledge of this mitochondrial unfolded protein response (UPR(mt)), compare it with the better understood UPR of the endoplasmic reticulum and highlight its potential impact on development and disease...
  76. pmc Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
    Maria M Mihaylova
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 145:607-21. 2011
    ..Finally, suppression of class IIa HDACs in mouse models of type 2 diabetes ameliorates hyperglycemia, suggesting that inhibitors of class I/II HDACs may be potential therapeutics for metabolic syndrome...
  77. ncbi The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Michael A Cowley
    The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Neuron 37:649-61. 2003
    ..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis.
  78. pmc Nutrient sensing and inflammation in metabolic diseases
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:923-34. 2008
    ..of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival...
  79. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
    ..We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cells...
  80. ncbi AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    Barbara B Kahn
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 1:15-25. 2005
    ..leptin, adiponectin, and possibly resistin) in regulating food intake, body weight, and glucose and lipid homeostasis. AMPK is regulated by upstream kinases of which the tumor suppressor, LKB1, is the first to be identified...
  81. ncbi Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis
    C E Outten
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Science 292:2488-92. 2001
    ..Thus, cells exert tight control over cytosolic metal concentrations, even for relatively low-toxicity metals such as zinc...
  82. pmc Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    David Patsouris
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Cell Metab 8:301-9. 2008
    ..Together, these results indicate that these CD11c+ cells are a potential therapeutic target for treatment of obesity-related insulin resistance and type II diabetes...
  83. pmc Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    Huaqi Jiang
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cell 137:1343-55. 2009
    ..Gut homeostasis is maintained by intestinal stem cells (ISCs) that divide to replenish the intestinal epithelium, but little is ..
  84. ncbi Reactive oxygen species as signals that modulate plant stress responses and programmed cell death
    Tsanko S Gechev
    Institute of Plant Sciences, ETH Zurich, Switzerland
    Bioessays 28:1091-101. 2006
  85. doi Origin and physiological roles of inflammation
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 454:428-35. 2008
    ..Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases...
  86. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
    ..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis.
  87. ncbi Use and abuse of HOMA modeling
    Tara M Wallace
    Oxford Centre for Diabetes, Endocrinology and Metabolism, The Churchill Hospital, Old Road, Oxford OX3 7LJ, U K
    Diabetes Care 27:1487-95. 2004
    ..However, as with all models, the primary input data need to be robust, and the data need to be interpreted carefully...
  88. ncbi Network motifs: theory and experimental approaches
    Uri Alon
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Rev Genet 8:450-61. 2007
    ..Here I review network motifs and their functions, with an emphasis on experimental studies. Network motifs in other biological networks are also mentioned, including signalling and neuronal networks...
  89. pmc The role of estrogens in control of energy balance and glucose homeostasis
    Franck Mauvais-Jarvis
    Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Endocr Rev 34:309-38. 2013
    ..the literature in both rodents and humans on the role of estrogens and their receptors in the control of energy homeostasis and glucose metabolism in health and metabolic diseases...
  90. doi Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina
    Anand Swaroop
    Neurobiology Neurodegeneration and Repair Laboratory, Building 6 338, MSC 0610, National Eye Institute, National Institutes of Health, 6 Center Drive, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 11:563-76. 2010
    ..Elucidation of gene-regulatory networks that dictate photoreceptor genesis and homeostasis will have wider implications for understanding the development of nervous system function and for the treatment ..
  91. pmc Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein
    Jacinthe Azevedo
    Institut de Biologie Moleculaire des Plantes du CNRS, Universite de Strasbourg, 67084 Strasbourg Cedex, France
    Genes Dev 24:904-15. 2010
    ..The likely widespread occurrence and expected consequences of GW protein mimicry on host silencing pathways are discussed in the context of innate and adaptive immunity in plants and metazoans...
  92. ncbi Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    Mitsuhiro Watanabe
    Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch, France
    Nature 439:484-9. 2006
    ..This indicates that BAs might be able to function beyond the control of BA homeostasis as general metabolic integrators...
  93. pmc Triacylglycerol homeostasis: insights from yeast
    Sepp D Kohlwein
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 285:15663-7. 2010
    ..Based on these similarities, studies performed in yeast may provide further significant mechanistic insight into the molecular basis of triacylglycerol homeostasis and its important physiological roles in healthy and diseased cells.
  94. doi Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
    Thomas Braun
    Max Planck Institute for Heart and Lung Research, Department for Cardiac Development and Remodelling, Benekestrasse, Bad Nauheim, Germany thomas braun mpi bn mpg de
    Nat Rev Mol Cell Biol 12:349-61. 2011
    ..It has also emerged that there is extensive post-transcriptional regulation by microRNAs in development and postnatal remodelling...
  95. pmc Autocrine VEGF signaling is required for vascular homeostasis
    Sunyoung Lee
    Department of Molecular, Cellular and Developmental Biology, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA
    Cell 130:691-703. 2007
    ..Here we show that in the absence of any pathological insult, autocrine VEGF is required for the homeostasis of blood vessels in the adult...
  96. pmc Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
    Nat Immunol 10:176-84. 2009
    ..These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals.
  97. pmc Cortical firing and sleep homeostasis
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Neuron 63:865-78. 2009
    ..to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not ..
  98. ncbi Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
    Alexander Link
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Nat Immunol 8:1255-65. 2007
    ..Here we report a critical function for lymph node access in T cell homeostasis and identify T zone fibroblastic reticular cells in these organs as the main source of interleukin 7...
  99. doi Involvement of OsSPX1 in phosphate homeostasis in rice
    Chuang Wang
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China
    Plant J 57:895-904. 2009
    ..This suggests that OsSPX1 acts via a negative feedback loop to optimize growth under phosphate-limited conditions...
  100. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
  101. pmc Bmi1 is expressed in vivo in intestinal stem cells
    Eugenio Sangiorgi
    Howard Hughes Medical Institute and Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Nat Genet 40:915-20. 2008
    ..Unexpectedly, the distribution of Bmi1-expressing stem cells along the length of the small intestine suggested that mammals use more than one molecularly distinguishable adult stem cell subpopulation to maintain organ homeostasis.

Research Grants73

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  3. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..If these mutations disrupt the function of key regulatory genes involved in cell growth and homeostasis, premature aging or cancer can occur...
  4. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..That glucose homeostasis depends upon regulation of PDC, which in turn depends upon hormonal control of the amounts of the PDKs, was the ..
  5. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..through B cell OPG production, and modulated by T cell costimulation, are critical regulators of basal bone homeostasis in young mice and mitigate in part, the enhanced bone resorption associated with aging"...
  6. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..obesity and obesity-related metabolic disorders (changes in insulin responsiveness and derangements in lipid homeostasis) in 2209 study subjects from 507 families participating in the Take Off Pounds Sensibly (TOPS) obesity research ..
  7. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..CST maintains glucose homeostasis by balancing increased gluconeogenesis with increased glucose disposal and decreased glycogenolysis...
  8. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..gastrointestinal hormones in response to meal stimuli play an important role in the regulation of body weight homeostasis. A complete understanding of this mechanism will improve the quality of life in our veteran patients by ..
  9. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..It is also unknown whether enhancing the decline anabolic homeostasis by providing testosterone (T) replacement therapy (TRT) would reverse body composition and metabolic profile ..
  10. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..propose our central hypothesis, which states that SPL plays a critical role in muscle biology, development and homeostasis. The specific aims of our proposal are, thus: 1) To define the role of SPL in muscle cell biology;2) To dissect ..
  11. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..of SCD1 expression by dietary MR is an essential component of the mechanism used by MR to affect energy homeostasis and limit fat deposition...
  12. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..LO as a metalloenzyme is susceptible to changes in cellular metal homeostasis. Previous studies by this lab investigating the phenotype change from Cd sensitive to Cd resistant of rat lung ..
  13. Regulation of ER stress-induced cell death
    Randal J Kaufman; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Diabetes is a world-wide epidemic characterized by an abnormality in glucose homeostasis that results from a failure of beta cells to produce insulin...
    Michael J LaMonte; Fiscal Year: 2013
    ..syndrome (Metsyn) is a condition of coexisting abnormalities in glucose, lipid, blood pressure, and body fat homeostasis, that affects more than half of U.S. adults 55 years and older...
  15. Med1 in Liver Metabolism, Regeneration and Cancer
    Janardan K Reddy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The liver plays a pivotal role in energy homeostasis by orchestrating biochemical pathways of carbohydrate, fat, and protein metabolism and exhibits inherent compensatory regeneration capacity to ..
    Maureen J Charron; Fiscal Year: 2010
    ..of hepatic substrate utilization and insulin sensitivity is crucial for maintenance of whole body glucose homeostasis as it integrates signals from the gut, peripheral tissue and central nervous system...
  17. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..and the dysregulation that we demonstrate occurs in diabetes, should have important consequences for iron homeostasis and inflammation, both of which have been demonstrated to contribute to diabetes pathogenesis...
  18. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..mice, to determine the full range of 13(V) roles in ultrastructure, cell biology, development, metabolism, homeostasis and disease - the latter including possible heritable diseases and/or predispositions to chronic ailments in ..
  19. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Multiple mechanisms such as lipotoxicity, glucotoxicity, oxidative stress, impaired myocardial calcium homeostasis and impaired insulin signaling have been implicated...
  20. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..Reasons proposed in the literature to explain why retinoid homeostasis is impaired in alcoholics are: 1...
  21. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..addition, salt-sensitive hypertension is associated with and linked to deficiencies in renal PGE2 synthesis and homeostasis. The physiologic and/or cellular triggers regulating PGE2 production in the distal nephron that maintain ..
  22. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..relevance of full-length and cleaved villin fragments respectively, in the maintenance of gastrointestinal homeostasis;(ii) to characterize the interaction of villin with ATP synthase 2- subunit to examine the relevance of this ..
  23. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..of cellular iron levels, suggesting a new and unanticipated role for the mammalian siderophore in cellular iron homeostasis. We will probe the role of IRE-IRP network in the regulation of the mammalian siderophore levels and in ..
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..the effects of FOX01 repression of PPAR3 on overall in vivo insulin sensitivity TZD-responsiveness and glucose homeostasis. Finally, CD11c+ macrophage represents the majority of the macrophages recruited into obese adipose tissues...
  25. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..Now recent evidence has emerged demonstrating that the Na/Ca exchanger plays a role in nuclear calcium homeostasis in some cells which immediately suggests that there must be a sodium concentration gradient across the nuclear ..
  26. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..immunopathology Macrophages (MF) form a heterogeneous population of mononuclear phagocytes necessary for organ homeostasis, host defense, and immunoregulation...
  27. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ..These proteins may affect astrocyte homeostasis, which in turn will influence neuronal function or might be secreted and taken up by neurons to directly affect ..
  28. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..and the mineralocorticoid receptor, thus regulating cochlear gene expression via immune suppression and ion homeostasis, respectively...
  29. Regulation of microRNA-375 by cyclic-AMP in pancreatic beta-cells
    DAVID MATTHEW KELLER; Fiscal Year: 2010
    ..messenger signaling cascade is a key regulator of diverse cellular process such as insulin secretion and energy homeostasis (Seino and Shibasaki, 2005)...
  30. The Kallikrein/Kinin-Mast Cell Interaction in Volume Overload
    CHIH CHANG KEVIN WEI; Fiscal Year: 2013
    ..We will study the effects of kallikrein inhibition on in vivo LV function, ECM homeostasis, ISF BK and chymase activity, and mast cell degranulation in response to VO in the early and chronic time ..
  31. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
    ..to the loss of BDNF signaling and thus a functional BDNF system is more crucial in the regulation of energy homeostasis in females...
  32. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2013
    ..rats with zoledronic acid at early and late time points and determine the effect of serum measures of mineral homeostasis, bone turnover, architecture and biomechanics, and arterial calcification, aorta compliance and left ..
  33. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..axonal information from other regions of the brain that also play important roles in CNS regulation of energy homeostasis, and sending out efferent information that regulates food intake and utilization...
  34. Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid Metabolism
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2013
    ..that genetic inhibition of hepatic Notch action demonstrated beneficial effects in both glucose and lipid homeostasis. These effects were recapitulated by pharmacologic inhibitors of Notch action, which were able to markedly ..
  35. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..for how OC interacting with adipocytes, pancreatic 2 cells and other molecules functionally involved in glucose homeostasis are still unclear...
  36. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..Alteration of bile acid synthesis impairs metabolic homeostasis leading to diabetes, obesity, and cardiovascular diseases...
  37. Iron in the pathogenesis of Friedreich's ataxia
    ..Its putative normal function is the biogenesis of iron- sulfur (Fe-S) clusters conveying iron homeostasis to the entire cell...
  38. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..studies will test the novel hypothesis that the osteoblast plays a critical role in the maintenance of glucose homeostasis. Specific Aim 2: Define the mechanisms through which OC influences pancreatic ss-cell function Preliminary ..
  39. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bone homeostasis in the adult or aging skeleton, is perturbed by mechanisms that involve decreased defense against oxidative stress and/or increased production of Reactive Oxygen Species (ROS)...
  40. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..ER stress induced by accumulation of misfolded proteins and alterations in calcium homeostasis can trigger apoptosis...
  41. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..Activation of the HPA axis is a basic response of animals to environmental perturbations that threaten homeostasis. These responses are regulated by neurons residing in the paraventricular nucleus of the hypothalamus (PVN) ..
    Francis W Luscinskas; Fiscal Year: 2013
    ..The vascular endothelium plays an active and vital role in regulating inflammatory responses and in maintaining homeostasis of the innate and adaptive immune systems...
  43. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    ..Hepcidin is a circulatory peptide synthesized in the liver. It plays a central role in iron homeostasis by regulating both intestinal and reticulo-endothelial iron transport...
  44. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..regarding the role and regulation of adipose LDL receptors and its relationship to whole body cholesterol homeostasis. Also, our knowledge of the signaling pathway controlling adipose endocrine and lipo-metabolic functions ..
  45. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..Ultimately, Dr. Bhave hopes to translate his seminal biochemical discovery into an independent line of investigation examining the role of peroxidasin in matrix remodeling and expansion in renal disease. ..
  46. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..results of these studies will provide valuable insight into how aldosterone and ET-1 interact to modulate Na homeostasis. Importantly, these studies will lend understanding into a novel signaling pathway that may explain the role of ..
  47. Ceramide Metabolism and Photoreceptor Homeostasis
    Usha R Acharya; Fiscal Year: 2013
    ..the focus of this project is to continue to understand how sphingolipid metabolism regulates photoreceptor homeostasis. The specific aims of the project are: (1) To obtain further insight into ceramide mediated disruption of ..
  48. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bile acids are crucial for lipid homeostasis in the liver. During the last decade, researchers have discovered that bile acids not only act as detergents, but also as important signaling molecules...
  49. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ..we will examine the effects of aerobic exercise-training on neurocognitive function, and on cerebral glucose homeostasis. It is yet to be determined whether AAs with mild AD can be recruited into such a study, nor has the ..
  50. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..This hypothesis will be tested through the exploration of the function of specific LD-associated proteins on LD homeostasis and cholesterol transport for steroidogenesis...
  51. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..The eicosanoid prostaglandin E2 (PGE2) can regulate embryonic HSC formation and adult homeostasis across vertebrate species...
  52. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..epithelial cels, develop spontaneous colitis because of an inability to maintain intestinal bacterial homeostasis. Further, upon rederivation of TLR5KO mice via embryonic transfer, ocurence of spontaneous colitis was ..
  53. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..hormone only, lack of significant glucose changes, lack of measurement of potential confounders such as insulin homeostasis, or examination only in Caucasians of European ancestry...
  54. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..lung cell proliferation and apoptosis, as well as extracellular matrix degradation, can alter lung cell homeostasis and architecture, leading to the development and progression of COPD...
  55. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..parts of the normal human and rat brain, only a few of which are involved in hemodynamic, fluid and electrolyte homeostasis and neurally modulated inflammatory processes...
    Cornelia M Weyand; Fiscal Year: 2012
    ..The current application will investigate this defect in T cell homeostasis and builds on our preliminary data, demonstrating a striking impairment in the survival of na[unreadable]ve CD4 ..
  57. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..Lysyl oxidase-like 1 (LOXL1) is a protein essential for elastin remodeling and homeostasis. Unlike in normal mice, vaginal delivery in LOXL1 knockout (KO) mice results in POP and SUI, making it an ideal ..
  58. Regulation of K-Ras by a Farnesyl-electrostatic Switch
    MARK REID PHILIPS; Fiscal Year: 2013
    ..We will ascertain if phospho-K-Ras alters mitochondrial calcium homeostasis. We will determine if IP3R, calpain and autophagy are required for phospho-K-Ras mediated cell death...
  59. Neural Functioning of Feeding Centers in Obese Youth
    ROBERT STANLEY SHERWIN; Fiscal Year: 2013
    ..in conjunction with high circulating insulin levels, might also display abnormal neuronal activity in certain regions of the brain, some of which are known to be key regulators of energy homeostasis and food seeking behavior.
  60. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..transcription factors have been identified as key regulators of genes involved in both cholesterol and lipid homeostasis. Because of the prominence of aberrant cholesterol and lipid homeostasis in the metabolic dysregulation ..
  61. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..clinical and experimental findings suggest that alcohol abuse and HIV-1 infection both interfere with zinc homeostasis and activation of anti-oxidant defenses within the airway and thereby render the lung susceptible to injury...
  62. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    ..Runx2 is a master osteoblast transcription factor playing pivotal roles in skeletal development and homeostasis. In humans, Runx2 haplotypes contribute to variations in bone mass...
  63. The Effects of Hyper and Hypocapnia on Phonatory Laryngeal Resistance
    Amanda I Gillespie; Fiscal Year: 2012
    ..by applicant): The larynx has a challenging dual role in the simultaneous regulation of breathing for blood-gas homeostasis and voice production for communication...
  64. Beauveriolide-Derived Cyclodepsipeptides as a New Class of Anti-Alzheimer's Drugs
    Paul Wentworth; Fiscal Year: 2010
    ..It has been shown definitively that the generation and clearance of A2 in the CNS is regulated by cholesterol homeostasis. Compounds that perturb cellular free cholesterol homeostasis such as acyl-coenzyme A: cholesterol ..
  65. Neuroendocrine Response to Gastric Bypass in Nonhuman Primates
    Randy J Seeley; Fiscal Year: 2010
    ..of physiological systems, including the regulation of ingestive behavior, energy expenditure and glucose homeostasis. In contrast to restrictive diets, surgery-induced weight loss is associated with decreased hunger and hedonic ..
  66. Understanding the role of bile as a mechanism for improved glucose homeostasis fo
    APRIL DAWN STRADER; Fiscal Year: 2010
    ..Interposition has been shown to improve glucose homeostasis in rat models of diabetes. Importantly, ileal interposition improves type-II diabetes in humans...
  67. Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ..by applicant): Our overall aim is to investigate the effects of dietary fatty acid composition on glucose homeostasis in women with polycystic ovary syndrome (PCOS)...
    LINDA GREENBAUM; Fiscal Year: 1999
    ..Despite the loss of two-thirds of the liver mass, metabolic and synthetic homeostasis is maintained...
  69. Redox Biology in COPD
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..Yet, the concept that oxidants are molecules with regulatory functions important in normal cell and tissue homeostasis has also emerged...
  70. Amyloid Beta-Protein: ApoE and Cholesterol Homeostasis
    WELLINGTON WOOD; Fiscal Year: 2009
    This application focuses on mechanisms of amyloid beta-protein perturbation of cholesterol and apoE homeostasis within astrocytes and resulting consequences on neuronal function...
  71. Cholesterol Homeostasis in Framingham Offspring Study
    Alice Lichtenstein; Fiscal Year: 2006
    The objective of this application is to investigate the predictive value of using measures of cholesterol homeostasis to identify individuals at high risk of developing cardiovascular disease (CVD) relative to established risk factors...
  72. Human Zinc Transporter Zip 13 and Cellular Zinc Homeostasis
    Joel Walker; Fiscal Year: 2007
    ..One mechanism to regulate cellular zinc homeostasis involves the Zrt-, Irt-like, Protein (ZIP) family of zinc transporters which function to import zinc into the ..
    ROGER CONE; Fiscal Year: 2003
    ..individuals to lose weight is the multifactorial neuroendocrine processes that function to maintain energy homeostasis. Decreased caloric intake results in a decrease in basal metabolic rate, and even decreased energy requirements ..