Summary: The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.

Top Publications

  1. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
  2. pmc Gene regulatory networks in the evolution and development of the heart
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1922-7. 2006
  3. doi Regulation of cell polarity during epithelial morphogenesis
    Fernando Martin-Belmonte
    Centro de Biologia Molecular Severo Ochoa, CSIC, UAM, 28049 Madrid, Spain
    Curr Opin Cell Biol 20:227-34. 2008
  4. doi Adherens junctions: from molecules to morphogenesis
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 11:502-14. 2010
  5. doi Self-organizing optic-cup morphogenesis in three-dimensional culture
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 472:51-6. 2011
  6. doi Collective cell migration in morphogenesis, regeneration and cancer
    Peter Friedl
    Microscopical Imaging of the Cell, Department of Cell Biology 283, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 10:445-57. 2009
  7. ncbi Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    T Lee
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 22:451-61. 1999
  8. ncbi Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
  9. pmc Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling
    Buzz Baum
    University College London, London WC1E 6BT, England, UK
    J Cell Biol 192:907-17. 2011
  10. pmc A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
    Ngan Vo
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:16426-31. 2005

Detail Information

Publications398 found, 100 shown here

  1. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..murine breast tumor model, we have found that the transcription factor Twist, a master regulator of embryonic morphogenesis, plays an essential role in metastasis...
  2. pmc Gene regulatory networks in the evolution and development of the heart
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1922-7. 2006
    ..The consequences of such mutations reveal the logic of organogenesis and the evolutionary origins of morphological complexity...
  3. doi Regulation of cell polarity during epithelial morphogenesis
    Fernando Martin-Belmonte
    Centro de Biologia Molecular Severo Ochoa, CSIC, UAM, 28049 Madrid, Spain
    Curr Opin Cell Biol 20:227-34. 2008
    ..The polarity of individual cells is oriented and coordinated with other cells by interactions with the extracellular matrix...
  4. doi Adherens junctions: from molecules to morphogenesis
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 11:502-14. 2010
    ..As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis.
  5. doi Self-organizing optic-cup morphogenesis in three-dimensional culture
    Mototsugu Eiraku
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 472:51-6. 2011
    ..We demonstrate that optic-cup morphogenesis in this simple cell culture depends on an intrinsic self-organizing program involving stepwise and domain-..
  6. doi Collective cell migration in morphogenesis, regeneration and cancer
    Peter Friedl
    Microscopical Imaging of the Cell, Department of Cell Biology 283, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 10:445-57. 2009
    ..migration of cells as a cohesive group is a hallmark of the tissue remodelling events that underlie embryonic morphogenesis, wound repair and cancer invasion...
  7. ncbi Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    T Lee
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 22:451-61. 1999
    ..As an example, we show that the short stop gene is required in mushroom body neurons for the extension and guidance of their axons...
  8. ncbi Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
    Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell rearrangements and cell movements...
  9. pmc Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling
    Buzz Baum
    University College London, London WC1E 6BT, England, UK
    J Cell Biol 192:907-17. 2011
    ..This turnover contributes to junction formation and to the maintenance of epithelial integrity during tissue homeostasis and remodeling...
  10. pmc A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
    Ngan Vo
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:16426-31. 2005
    ..We provide evidence that miR132 regulates neuronal morphogenesis by decreasing levels of the GTPase-activating protein, p250GAP...
  11. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
    ..Analysis of such mutants revealed that virulence requires the glycolipid glucosylceramide. To our knowledge, this is the first C. albicans small molecule that has been found to be required specifically for virulence...
  12. pmc Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis
    Cory L Simpson
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 12:565-80. 2011
    ..These architectural components are more than just rivets and scaffolds - they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation.
  13. ncbi p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 398:714-8. 1999
    ..Taken together, our results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis.
  14. ncbi Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nat Genet 38:356-62. 2006
    ..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ.
  15. ncbi The distinct morphogenic states of Candida albicans
    Peter Sudbery
    Sheffield University, Department of Molecular Biology and Biotechnology, Western Bank, Sheffield S10 2TN, UK
    Trends Microbiol 12:317-24. 2004
    ..We argue that studies on "filamentous forms" should always include a formal analysis to determine whether the cells are hyphae or pseudohyphae and we suggest some simple experimental criteria that can be applied to achieve this...
  16. ncbi The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:873-87. 2004
    ..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites...
  17. ncbi Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
    Jennifer M Halbleib
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:3199-214. 2006
    Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo)...
  18. ncbi De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
    U Gat
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Cell 95:605-14. 1998
    ..a stabilized beta-catenin controlled by an epidermal promoter undergo a process resembling de novo hair morphogenesis. The new follicles formed sebaceous glands and dermal papilla, normally established only in embryogenesis...
  19. ncbi Induction of pancreatic differentiation by signals from blood vessels
    E Lammert
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 294:564-7. 2001
    ..These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development...
  20. pmc Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    Christiana Ruhrberg
    Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 16:2684-98. 2002
    Branching morphogenesis in the mammalian lung and Drosophila trachea relies on the precise localization of secreted modulators of epithelial growth to select branch sites and direct branch elongation, but the intercellular signals that ..
  21. ncbi MicroRNAs regulate brain morphogenesis in zebrafish
    Antonio J Giraldez
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 308:833-8. 2005
    ..MZdicer mutants undergo axis formation and differentiate multiple cell types but display abnormal morphogenesis during gastrulation, brain formation, somitogenesis, and heart development...
  22. doi Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    Hellmut G Augustin
    Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, University of Heidelberg, and German Cancer Research Center Heidelberg DKFZ ZMBH Alliance, Germany
    Nat Rev Mol Cell Biol 10:165-77. 2009
    ..The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands provide unique insights into the functions of this vascular signalling system...
  23. pmc beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair
    David Enshell-Seijffers
    Cutaneous Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    Dev Cell 18:633-42. 2010
    ..This study reveals a signaling loop that employs Wnt/beta-catenin signaling in both epithelial progenitor cells and their mesenchymal niche to govern and coordinate the interactions between these compartments to guide hair morphogenesis.
  24. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
  25. pmc Integration of contractile forces during tissue invagination
    Adam C Martin
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 188:735-49. 2010
    ..the actomyosin cytoskeleton within individual cells collectively generate tissue-level force during epithelial morphogenesis. During Drosophila mesoderm invagination, pulsed actomyosin meshwork contractions and a ratchet-like ..
  26. ncbi Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
    Claire Bertet
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Nature 429:667-71. 2004
    Shaping a developing organ or embryo relies on the spatial regulation of cell division and shape. However, morphogenesis also occurs through changes in cell-neighbourhood relationships produced by intercalation...
  27. ncbi Fibroblast growth factor signaling during early vertebrate development
    Ralph T Böttcher
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Endocr Rev 26:63-77. 2005
    ..We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements...
  28. doi Developmental patterning by mechanical signals in Arabidopsis
    Olivier Hamant
    INRA, Laboratoire de Reproduction et Développement des Plantes, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Science 322:1650-5. 2008
    ..biology is whether and how mechanical forces serve as cues for cellular behavior and thereby regulate morphogenesis. We found that morphogenesis at the Arabidopsis shoot apex depends on the microtubule cytoskeleton, which in ..
  29. ncbi Modeling tissue morphogenesis and cancer in 3D
    Kenneth M Yamada
    Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 130:601-10. 2007
    ..These models may help to accelerate translational research in cancer biology and tissue engineering...
  30. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    ..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP.
  31. ncbi Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    A Vortkamp
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 273:613-22. 1996
    Proper regulation of chondrocyte differentiation is necessary for the morphogenesis of skeletal elements, yet little is known about the molecular regulation of this process...
  32. pmc Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila
    D P Kiehart
    Department of Cell Biology, Cell and Molecular Biology Program, University Program in Genetics and the Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710 3709, USA
    J Cell Biol 149:471-90. 2000
    The molecular and cellular bases of cell shape change and movement during morphogenesis and wound healing are of intense interest and are only beginning to be understood...
  33. pmc Hair follicle stem cells are specified and function in early skin morphogenesis
    Jonathan A Nowak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 3:33-43. 2008
    ..In the absence of early SCs, hair follicle and sebaceous gland morphogenesis is blocked, and epidermal wound repair is compromised...
  34. ncbi The cadherins: cell-cell adhesion molecules controlling animal morphogenesis
    M Takeichi
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 102:639-55. 1988
    ..Antibodies to cadherins were shown to perturb the morphogenesis of some embryonic organs in vitro...
  35. pmc Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging
    Cyrus M Ghajar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 8206, USA
    Histochem Cell Biol 130:1105-18. 2008
  36. pmc A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis
    Gabriele Siegel
    Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universitat Heidelberg, and Institut für Neuroanatomie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany
    Nat Cell Biol 11:705-16. 2009
    ..pathway has been implicated in the regulation of synaptic protein synthesis and ultimately in dendritic spine morphogenesis, a phenomenon associated with long-lasting forms of memory...
  37. doi Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis
    Romain Levayer
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 13:529-40. 2011
    E-cadherin plays a pivotal role in epithelial morphogenesis. It controls the intercellular adhesion required for tissue cohesion and anchors the actomyosin-driven tension needed to change cell shape...
  38. ncbi Sonic hedgehog mediates the polarizing activity of the ZPA
    R D Riddle
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 75:1401-16. 1993
    ..Like the ZPA, Sonic hedgehog expression leads to the activation of Hox genes. Sonic hedgehog thus appears to function as the signal for antero-posterior patterning in the limb...
  39. pmc Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
    Frank Costantini
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 18:698-712. 2010
    ..In this review, we will consider their embryological origin and the genes controlling their morphogenesis, patterning, and differentiation, with a focus on recent advances in several areas.
  40. pmc Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis
    Joanne Durgan
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 286:12461-74. 2011
    Cdc42 plays an evolutionarily conserved role in promoting cell polarity and is indispensable during epithelial morphogenesis. To further investigate the role of Cdc42, we have used a three-dimensional matrigel model, in which single Caco-..
  41. ncbi Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization
    George E Davis
    Department of Pathology, Texas A and M University System Health Science Center, College Station, USA
    Circ Res 97:1093-107. 2005
    ..signal transduction pathways, ECM controls the EC cytoskeleton to orchestrate the complex process of vascular morphogenesis by which proliferating ECs organize into multicellular tubes with functional lumens...
  42. ncbi Organizing activity of wingless protein in Drosophila
    G Struhl
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 72:527-40. 1993
    ..We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc...
  43. pmc Branching out: mechanisms of dendritic arborization
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California, 1550 4th Street, San Francisco 94158, USA
    Nat Rev Neurosci 11:316-28. 2010
    ..on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species...
  44. ncbi A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
    T P Yamaguchi
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    Development 126:1211-23. 1999
    b>Morphogenesis depends on the precise control of basic cellular processes such as cell proliferation and differentiation...
  45. pmc Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
    F J Naya
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 11:2323-34. 1997
    ..Islet morphogenesis appeared to be arrested between E14.5 and E17...
  46. pmc Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
    Rebecca S Shapiro
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Curr Biol 19:621-9. 2009
    ..This transition is normally regulated by environmental cues, such as exposure to serum, that are contingent upon elevated temperature to induce morphogenesis. The basis for this temperature dependence has remained enigmatic.
  47. pmc Candida albicans morphogenesis and host defence: discriminating invasion from colonization
    Neil A R Gow
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Nat Rev Microbiol 10:112-22. 2012
    ..In this Review, we describe the properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans...
  48. pmc puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
    E Martin-Blanco
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Genes Dev 12:557-70. 1998
  49. ncbi Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis
    Annie N Y Ng
    Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Dev Biol 286:114-35. 2005
    ..a framework for the future characterization of zebrafish mutant phenotypes in which intestinal epithelial morphogenesis has been disrupted...
  50. doi Reaction-diffusion model as a framework for understanding biological pattern formation
    Shigeru Kondo
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, 565 0871, Japan
    Science 329:1616-20. 2010
    ..In this review, we describe the essence of this theory for experimental biologists unfamiliar with the model, using examples from experimental studies in which the RD model is effectively incorporated...
  51. pmc Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop
    Wei Meng Woo
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 26:1235-46. 2012
    During hair follicle morphogenesis, dermal papillae (DPs) function as mesenchymal signaling centers that cross-talk with overlying epithelium to regulate morphogenesis...
  52. pmc Truffles regulate plant root morphogenesis via the production of auxin and ethylene
    Richard Splivallo
    Department of Crop Sciences, Molecular Phytopathology and Mycotoxin Research, Georg August University, D 37077 Goettingen, Germany
    Plant Physiol 150:2018-29. 2009
    ..Taken together, these results establish the central role of IAA and ethylene as signal molecules in truffle/plant interactions...
  53. pmc Notch signaling is essential for vascular morphogenesis in mice
    L T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 14:1343-52. 2000
    ..These results reveal an essential role for the Notch signaling pathway in regulating embryonic vascular morphogenesis and remodeling, and indicate that whereas the Notch4 gene is not essential during embryonic development, the ..
  54. pmc Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival
    Nicola V L Serão
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    BMC Med Genomics 4:49. 2011
    ..The goal of this study was to identify general and clinical-dependent biomarker genes and biological processes of three complementary events: lifetime, overall and progression-free glioblastoma survival...
  55. ncbi Recent advances in craniofacial morphogenesis
    Yang Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    Dev Dyn 235:2353-75. 2006
    ..Here, we highlight recent advances in our understanding of evo-devo as it relates to craniofacial morphogenesis, fate determination of cranial neural crest cells, and specific signaling pathways in regulating tissue-tissue ..
  56. pmc Junctional trafficking and epithelial morphogenesis
    Frederik Wirtz-Peitz
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Curr Opin Genet Dev 19:350-6. 2009
    ..Here we describe recent progress in understanding the roles of the vesicle transport machinery in regulating cell adhesion and junctional dynamics during epithelial morphogenesis in vivo.
  57. pmc Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
    Eleni Bazigou
    Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 17:175-86. 2009
    Dysfunction of lymphatic valves underlies human lymphedema, yet the process of valve morphogenesis is poorly understood...
  58. ncbi p63 is a p53 homologue required for limb and epidermal morphogenesis
    A A Mills
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 398:708-13. 1999
    ..Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis...
  59. ncbi A tension-based theory of morphogenesis and compact wiring in the central nervous system
    D C Van Essen
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 385:313-8. 1997
    ..By keeping the aggregate length of axonal and dendritic wiring low, tension should contribute to the compactness of neural circuitry throughout the adult brain...
  60. ncbi Controls of hair follicle cycling
    K S Stenn
    Beauty Genome Sciences Inc, Skillman, New Jersey, USA
    Physiol Rev 81:449-494. 2001
    ..For the immediate future, our challenge is to define the molecular basis for hair follicle growth control, to regenerate a mature hair follicle in vitro from defined populations, and to offer real solutions to our patients' problems...
  61. doi Epithelial polarity and morphogenesis
    Daniel St Johnston
    The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QN, United Kingdom
    Curr Opin Cell Biol 23:540-6. 2011
    ..Here we discuss the role played by modifications in the apical-basal polarity system in driving morphogenesis, with an emphasis on well-characterised events during Drosophila development...
  62. pmc Eye morphogenesis and patterning of the optic vesicle
    Sabine Fuhrmann
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
    Curr Top Dev Biol 93:61-84. 2010
    ..followed by invagination of the distal domain of the vesicles and the overlying lens placode resulting in morphogenesis of the optic cup...
  63. pmc The extracellular matrix in development and morphogenesis: a dynamic view
    Tania Rozario
    Department of Cell Biology and the Morphogenesis and Regenerative Medicine Institute, University of Virginia, PO Box 800732, School of Medicine, Charlottesville, VA 22908, USA
    Dev Biol 341:126-40. 2010
    ..that the extracellular microenvironment is critically important for cell growth, survival, differentiation and morphogenesis. ECM and the cellular receptors that interact with it mediate both physical linkages with the cytoskeleton and ..
  64. pmc A molecular network for de novo generation of the apical surface and lumen
    David M Bryant
    Department of Anatomy, University of California, San Francisco, CA 94143 2140, USA
    Nat Cell Biol 12:1035-45. 2010
    ..This Rab11a-directed network directs Cdc42-dependent apical exocytosis during lumen formation, revealing an interaction between the machineries of vesicular transport and polarization...
  65. doi External forces control mitotic spindle positioning
    Jenny Fink
    Institut Curie, CNRS UMR 144, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Cell Biol 13:771-8. 2011
    The response of cells to forces is essential for tissue morphogenesis and homeostasis. This response has been extensively investigated in interphase cells, but it remains unclear how forces affect dividing cells...
  66. pmc Mechanical control of tissue and organ development
    Tadanori Mammoto
    Vascular Biology Program, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 137:1407-20. 2010
    ..of physics, engineering and biology that suggests that mechanical forces generated by living cells are as crucial as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning.
  67. pmc APSES proteins regulate morphogenesis and metabolism in Candida albicans
    Thomas Doedt
    Institut fur Mikrobiologie, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Biol Cell 15:3167-80. 2004
    ..Unexpectedly, Efg1p not only regulates genes involved in morphogenesis but also strongly influences the expression of metabolic genes, inducing glycolytic genes and repressing genes ..
  68. pmc Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung
    Laura L Yates
    Mammalian Genetics Unit, Medical Research Council, Harwell, UK
    Dev Biol 373:267-80. 2013
    ..Lung branching and lumen morphogenesis require close epithelial cell-cell contacts that are maintained as a result of adherens junctions, tight ..
  69. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..We report that Gata-3 has essential roles in the morphogenesis of the mammary gland in both the embryo and adult...
  70. ncbi Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    V Kaartinen
    Department of Pathology, Childrens Hospital of Los Angeles Research Institute, California 90027, USA
    Nat Genet 11:415-21. 1995
    ..This study demonstrates an essential function for TGF-beta 3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial-mesenchymal interaction.
  71. doi V-ATPase-dependent ectodermal voltage and pH regionalization are required for craniofacial morphogenesis
    Laura N Vandenberg
    The Tufts Center for Regenerative and Developmental Biology, and Biology Department, Tufts University, Medford, Massachusetts, USA
    Dev Dyn 240:1889-904. 2011
    ..We conclude that this bioelectric signal has a role in development of the face. Thus, it exemplifies an important, under-studied mechanism of developmental regulation...
  72. ncbi Fungal morphogenesis and host invasion
    Neil A R Gow
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, AB25 2ZD, Aberdeen, UK
    Curr Opin Microbiol 5:366-71. 2002
    ..However, molecular control circuits that regulate morphogenesis also regulate the expression of other virulence traits...
  73. doi Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability
    Isabelle Mouyna
    Unite des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux 75724 Paris Cedex 15, France
    Mol Microbiol 76:1205-21. 2010
    ..These results indicate that the PMT family members play a major role in growth, morphogenesis and viability of A. fumigatus.
  74. pmc Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries
    Jeffrey O Bush
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 24:2068-80. 2010
  75. doi TGFbeta-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis
    Judith Stegmuller
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:1961-9. 2008
    ..and its substrate the transcriptional modulator SnoN form a cell-intrinsic pathway that orchestrates axonal morphogenesis in the mammalian brain. How the Cdh1-APC/SnoN pathway is controlled in the nervous system remained unknown...
  76. doi Cryptococcus neoformans: morphogenesis, infection, and evolution
    Xiaorong Lin
    Department of Biology, Texas A and M University, 3258 TAMU, College Station, TX 77843 3258, USA
    Infect Genet Evol 9:401-16. 2009
    ..roles of each form inside and outside of mammalian hosts and summarizes recent insights on the life cycle and morphogenesis of this fungus and their impact on the pathogenicity. Application of recently developed advanced tools for C...
  77. doi Control of Dpp morphogen signalling by a secreted feedback regulator
    Robin Vuilleumier
    Institute for Biology I, Albert Ludwigs University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    Nat Cell Biol 12:611-7. 2010
    ..We show that Pent interacts with the glypican Dally to control Dpp distribution and provide evidence that proper establishment of the BMP morphogen gradient requires the inbuilt feedback loop embodied by Pent...
  78. doi Signaling by members of the TGF-beta family in vascular morphogenesis and disease
    Evangelia Pardali
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
    Trends Cell Biol 20:556-67. 2010
    ..These advances provide opportunities for the development of new therapies for diseases with vascular abnormalities...
  79. doi Pulsed forces timed by a ratchet-like mechanism drive directed tissue movement during dorsal closure
    Jerome Solon
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Cell 137:1331-42. 2009
    ..Our work uncovers a sophisticated mechanism of cooperative force generation between two major forces driving morphogenesis.
  80. ncbi Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways
    Vikas Kumar
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 25:11288-99. 2005
    ..Although many proteins have been identified recently as regulators of dendritic morphogenesis, the intracellular signaling pathways that control these processes are not well understood...
  81. ncbi Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis
    Michael Klüppel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Development 132:3989-4003. 2005
    ..proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis. Our study demonstrates an important biological role of differential chondroitin sulfation in mammalian ..
  82. pmc Early steps in the development of the forebrain
    Stephen W Wilson
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Cell 6:167-81. 2004
    ..Here, we discuss early events in forebrain development--those that lead to the establishment of the anterior neural plate and the regional subdivision of this territory into the different domains of the prospective forebrain...
  83. ncbi Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis
    Ying Fu
    Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA
    Cell 120:687-700. 2005
    ..between adjacent cells is a critical yet poorly understood aspect of tissue development and organ morphogenesis. We report a Rho GTPase signaling network underlying the jigsaw puzzle appearance of Arabidopsis leaf pavement ..
  84. ncbi Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis
    B Glise
    Centre de Biologie du Developpement, Unité Mixte de Recherche UMR 5547 Centre National de la Recherche Scientifique CNRS, Toulouse, France
    Genes Dev 11:1738-47. 1997
    ..Dorsal closure couples JNK and dpp signaling pathways, a situation that may be conserved in vertebrate development...
  85. doi Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis
    Catarina C F Homem
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 135:1005-18. 2008
    ..We used loss- and gain-of-function approaches to examine the role of Diaphanous in Drosophila morphogenesis. We found that Diaphanous has a dynamic expression pattern consistent with a role in regulating cell shape ..
  86. ncbi Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches
    M Qiu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Biol 185:165-84. 1997
    ..Finally, the Dlx-2 and Dlx-1 and -2 mutants have ectopic skull components that resemble bones and cartilages found in phylogenetically more primitive vertebrates...
  87. doi Mechanics of epithelial tissue homeostasis and morphogenesis
    Charlène Guillot
    Aix Marseille Universite, CNRS UMR 7288, IBDM, Campus de Luminy, Marseille, France
    Science 340:1185-9. 2013
    ..Epithelial cells can change shape or intercalate as tissues deform during morphogenesis. We review the mechanical basis of tissue robustness and fluidity, with an emphasis on the pivotal role of ..
  88. doi Force generation, transmission, and integration during cell and tissue morphogenesis
    Thomas Lecuit
    Developmental Biology Institute of Marseilles Luminy, Centre National de la Recherche Scientifique, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    Annu Rev Cell Dev Biol 27:157-84. 2011
    ..These are now complemented by studies in developing organisms that emphasize how cell and tissue morphogenesis emerge from the interplay between force-generating machines, such as actomyosin networks, and adhesive ..
  89. pmc Molecular control of endothelial cell behaviour during blood vessel morphogenesis
    Shane P Herbert
    Department of Biochemistry and Biophysics, Program in Developmental Biology, Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Nat Rev Mol Cell Biol 12:551-64. 2011
    ..proliferation, polarity, differentiation and cell-cell communication is critical for functional blood vessel morphogenesis. Recent data uncover elaborate transcriptional, post-transcriptional and post-translational mechanisms that ..
  90. pmc Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
    Rusty L Montgomery
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Genes Dev 21:1790-802. 2007
    ..cell-autonomous and non-cell-autonomous functions for HDAC1 and HDAC2 in the control of myocardial growth, morphogenesis, and contractility, which reflect partially redundant roles of these enzymes in tissue-specific ..
  91. doi The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival
    Ulrich Tepass
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Annu Rev Cell Dev Biol 28:655-85. 2012
    ..increasingly clear that APRs interact with the cytoskeleton and vesicle trafficking machinery, regulate morphogenesis, and modulate epithelial cell growth and survival...
  92. pmc Local cortical tension by myosin II guides 3D endothelial cell branching
    Robert S Fischer
    Laboratory of Cell and Tissue Morphodynamics, Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 19:260-5. 2009
    A key feature of angiogenesis is directional control of endothelial cell (EC) morphogenesis and movement [1]...
  93. ncbi Laminin functions in tissue morphogenesis
    Jeffrey H Miner
    Renal Division, Department of Internal Medicine and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Annu Rev Cell Dev Biol 20:255-84. 2004
    ..These studies have shown that different laminin subunits profoundly affect tissue morphogenesis, starting around the time of embryonic implantation and extending through organogenesis and into the postnatal ..
  94. ncbi Cell biology of cardiac cushion development
    Anthony D Person
    Department of Cell Biology and Anatomy, University of Arizona School of Medicine, Tucson, Arizona 85724, USA
    Int Rev Cytol 243:287-335. 2005
    ..Cushion morphogenesis is unique in that these cellular possesses occur in a functioning organ where the cushions act as valves even ..
  95. pmc LGN regulates mitotic spindle orientation during epithelial morphogenesis
    Zhen Zheng
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Cell Biol 189:275-88. 2010
    Coordinated cell polarization and mitotic spindle orientation are thought to be important for epithelial morphogenesis. Whether spindle orientation is indeed linked to epithelial morphogenesis and how it is controlled at the molecular ..
  96. ncbi Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development
    I Satokata
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Nat Genet 6:348-56. 1994
    ..The Msx1-/Msx1- phenotype is similar to human cleft palate, and provides a genetic model for cleft palate and oligodontia in which the defective gene is known...
  97. pmc Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis
    Pengfei Lu
    Department of Anatomy and Program in Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Dev Biol 321:77-87. 2008
    ..Together, our data demonstrate that Fgfr2 functions in the proliferating and invading TEBs, but it is not required in the mature ducts of the pubertal mammary gland...
  98. pmc The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis
    Alejo E Rodríguez-Fraticelli
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Madrid 28049, Spain
    J Cell Biol 189:725-38. 2010
    ..which is a master regulator of cell polarity, regulates the formation of the central lumen in epithelial morphogenesis. However, how Cdc42 is regulated during this process is still poorly understood...
  99. ncbi PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance
    Stephan K H Prill
    Institut fur Mikrobiologie, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Microbiol 55:546-60. 2005
    ..Hyphal morphogenesis of a pmt4 mutant was defective under aerobic induction conditions, yet increased in embedded or hypoxic ..
  100. pmc Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis
    M Komada
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 13:1475-85. 1999
    ..These phenotypes arise from a defect in ventral folding morphogenesis that occurs normally around E8.0...
  101. ncbi Effective targeted gene 'knockdown' in zebrafish
    A Nasevicius
    Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA
    Nat Genet 26:216-20. 2000
    ..Conserved vertebrate processes and diseases are now amenable to a systematic, in vivo, reverse-genetic paradigm using zebrafish embryos...

Research Grants118 found, 100 shown here

  1. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..The tumor microenvironment is responsible for stimulating a morphogenesis within carcinoma cells referred to as epithelial to mesenchymal transition (EMT)...
  2. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    ..tissue formation by exploring the role of GTPase Rac signaling in the regulation of salivary gland branching morphogenesis and tissue polarization, processes that are crucial for development of a functional organ...
    Alvaro Puga; Fiscal Year: 2013
    ..5, a key determinant of cardiac morphogenesis. Our rationale is that mutations in the NKX2...
  4. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..and malignant cells in 3D culture, but not in flat cell monolayers, indicating dependency on tissue morphogenesis. Nuclear organization is interconnected with tissue morphogenesis and carcinogenesis...
    Anisa Shaker; Fiscal Year: 2012
    ..Epimorphin (epim) is a stromal and myofibroblast protein that regulates intestinal epithelial morphogenesis. Epim-/- mice are partially protected from acute colitis in association with an increase in crypt cell ..
  6. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
    ..stabilization and/or localization to focal adhesions, where it is critical for FA turnover and cell morphogenesis/migration...
  7. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..Branching morphogenesis in the embryonic tracheal system is controlled by patterned interactions between a fibroblast growth factor (..
  8. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..of organs (Senior-Loken syndrome), whereas truncating mutations cause severe developmental defects during morphogenesis and lead to malformation or dysplasia (Meckel syndrome)...
    J Evan Sadler; Fiscal Year: 2013
    ..of platelets and angiogenesis in metastasis;biology of human immunodeficiency and leukemia viruses;epithelial morphogenesis;pathogenesis of leukemia, MDS, myeloproliferative neoplasms, and congenital neutropenia;cell cycle control;..
  10. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..2) Induction of hair morphogenesis in CSS by expression in keratinocytes of stabilized p-eatenin, either constitutively, or under an estrogen-..
  11. Regulation of IFN-beta induction by P2X7 purinergic receptor signaling
    JUDITH ANNE SMITH; Fiscal Year: 2011
    ..As both IFN- [unreadable] and purinergic receptor signaling have been implicated in bacterial sepsis and bone morphogenesis, it is critical to understand the mechanism of how P2X7 modulates the induction of IFN- [unreadable]...
    ALBERT HONG JAE KIM; Fiscal Year: 2013
    ..record of successful, published research projects in developmental and excitotoxic neuronal death and neuronal morphogenesis. To prepare for the transition to successful independent investigator, the candidate's career development ..
  13. Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast Milk
    Lynn Puddington; Fiscal Year: 2010
    ..monocyte recruitment from the blood followed by differentiation to macrophages in the breast during branching morphogenesis in the mammary gland...
    Ezra Burstein; Fiscal Year: 2013
    ..malignant transformation in the GI tract, particularly the esophagus and colon;cancer prevention and screening;morphogenesis of the digestive system;obesity, liver steatosis, lipid metabolism and gallstone disease;immune responses in ..
  15. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..role in respiratory physiology including regulation of airway tone, vasodilation, inflammation and lung morphogenesis. An alteration of NO production has been implicated in the pathology of numerous respiratory diseases such as ..
  16. Novel genetics, pathobiology &therapy of nephronophthisis-related ciliopathies
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..the following way: Two truncating mutations cause a severe, early- onset developmental phenotype that affects morphogenesis and leads to malformation or dysplasia (Meckel- Gruber syndrome), whereas two missense mutations cause only a ..
  17. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..polycystic kidney disease (ADPKD), co-localizes in the endothelial primary cilium together with the capillary morphogenesis gene-1 product (CMG-1), the human ortholog of CrIFT71, a component of the intraflagellar transport (IFT) ..
  18. Foxf1 Transcription Factor in Development of Pulmonary Capillaries
    Vladimir V Kalinichenko; Fiscal Year: 2013
    ..injury in newborn mice as a model of BPD to test the hypothesis that Foxf1 is required to maintain normal lung morphogenesis after hyperoxia injury by stimulating angiogenesis and increasing survival of endothelial cells...
  19. Role in Myopia Development of Retinal Pigment Epithelium - A New Therapeutic Targ
    Yan Zhang; Fiscal Year: 2013
    ..research focus is the TGF-[unreadable] family including BMPs and their roles in cell differentiation, tissue morphogenesis, and extracellular matrix production...
  20. NFAT Signaling and Down Syndrome
    Gerald R Crabtree; Fiscal Year: 2012
    ..transcription factors and signaling proteins and are essential to many aspects of vertebrate development and morphogenesis. This signaling and transcriptional pathway is required for signaling by neurotrophins, netrins, FGF, VEGF, ..
  21. Mechanisms of Pleural Fibrosis in Empyema
    Kamal A Mohammed; Fiscal Year: 2013
    ..major class of gene expression regulators linked to many biological functions including cell proliferation and morphogenesis. In preliminary studies, in MRSA infected HO-1 -/- PMC, we found an exaggerated expression of miR-26a and ..
  22. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ..This proposed research will not only answer the question of whether BPA- induced morphogenesis changes in different developmental windows of mammary gland has a stem cell origin, but also shed light on ..
  23. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..spermatogenesis is an ideal model system for genetic dissection of conserved mechanisms of mitochondrial morphogenesis, since mitochondria undergo dramatic shaping during sperm development...
    Kassim Traore; Fiscal Year: 2013
    ..During development, androgen plays a critical role in programming sex organ morphogenesis and function...
  25. Cloning &Functional Studies of Deafness Mutations
    Kenneth R Johnson; Fiscal Year: 2013
    ..of each gene, as they relate to such processes as inner ear development, endolymph homeostasis, hair cell morphogenesis, and mechanotransduction...
  26. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..We also showed retinal EC prepared from CYP1B1-/- mice are less migratory and fail to undergo capillary morphogenesis in Matrigel...
  27. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    ..growth factor (HGF) is a pleiotropic cytokine that promotes cell proliferation, motility, survival, and morphogenesis. HGF binds to its receptor c-Met tyrosine kinase and triggers signal transduction that protects cells against ..
    Licia Selleri; Fiscal Year: 2009
    ..genetic and developmental approaches, exploiting the mouse as a model system, to study skeletal patterning and morphogenesis during development...
    David J Feith; Fiscal Year: 2013
    ..First, skin sections will be analyzed to identify the developmental defects in hair follicle morphogenesis and cycling that are induced by AZ and AdoMetDC expression...
  30. Mammary Gland Morphogenesis and Breast Cancer
    Ian G Macara; Fiscal Year: 2013
    ..Yet the molecular mechanisms underlying polarity in mammary morphogenesis and the role of Par proteins in breast cancer remain largely unknown...
  31. Distinct roles of CARP target genes in wound healing
    Karinna Almodóvar; Fiscal Year: 2013
    ..Effective wound repair requires extracellular matrx (ECM) remodeling to allow cell migration and capillary morphogenesis. ECM remodeling and signaling cascades derived from this process dictate whether or to what extent tissue ..
  32. Encapsidation of the poxvirus genome
    Paula Traktman; Fiscal Year: 2012
    ..It is this process of genome encapsidation, which lies at the interface of replication and morphogenesis, that it is the focus of this exploratory application...
  33. Targeted epigenetic therapy of triple-negative breast cancer
    Samuel Waxman; Fiscal Year: 2013
    ..disrupts SID transcription factor binding to the Sin3A PAH2 domain induces profound phenotypic changes of morphogenesis, loss of invasion, contact inhibition in triple negative human and mouse breast cancer models in vitro and in ..
  34. Perinatal Stress and programming of childhood wheeze and lung function
    Rosalind J Wright; Fiscal Year: 2013
    ..postnatal development may alter risk for developing wheezing phenotypes and alter the normal course of lung morphogenesis and maturation, potentially impacting both structure and function of the respiratory system...
  35. Role of SATB in placental development
    Mohammad A K Rumi; Fiscal Year: 2013
    ..Revealing the fundamental regulators of TS cells will greatly expand our understanding of placental morphogenesis and the pathophysiology of placenta-associated disorders.
  36. Regulation of 22q11 Genes in Embroyonic and Adult Forebrain
    Anthony S LaMantia; Fiscal Year: 2013
    ..Genes regulated by signaling molecules that influence induction and morphogenesis at 22q11DS phenotypic sites including the heart, face, thymus, limbs, and forebrain. 2...
    John F Engelhardt; Fiscal Year: 2013 how Wnts, Noggin, and BMPs coordinate TCF/Sox regulation of the Lef-1 promoter during submucosal gland morphogenesis. Based on the inhibitory and enhancer functions of an identified Wnt-responsive element in the Lef-1 promoter, ..
  38. A Developmental Craniofacial Atlas for the Zebrafish
    Charles B Kimmel; Fiscal Year: 2010
    ..During stages of skeletal morphogenesis and growth, the cells making the skeleton will be revealed specifically by expression of markers including ..
    Richard J Kuhn; Fiscal Year: 2013
    ..studies investigating the assembly pathway of alphaviruses have proven extremely fruitful in understanding the morphogenesis pathway and structure of this group of simple, yet important, enveloped viruses...
  40. Mechanisms of FGFR2 Signaling in Craniofacial Development
    Veraragavan P Eswarakumar; Fiscal Year: 2013
    ..two Specific Aims to determine the mechanisms of FGFR2 signaling that govern craniofacial development and morphogenesis. In Aim 1...
  41. Role of Cofilin and Wnt Signaling in Neural Crest Development
    O apos NEIL WIGGAN; Fiscal Year: 2013
    Project Summary/Abstract Abstract: A key aspect of cell and tissue morphogenesis is regulation of the actin cytoskeleton...
  42. Transcriptional Control of Submucosal Gland Formation and Function
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..that PAX9 and an associated transcriptional network play a critical role in the regulation of AEC and SMG morphogenesis and function in the developing and mature airway...
  43. Regeneration of stereocilia of cochlear hair cells
    David Z Z He; Fiscal Year: 2010
    ..will determine whether over-expression of myosin-15a and whirlin, two genes that are involved in stereocilium morphogenesis, can promote hair-bundle repair/regeneration and whether the newly regenerated stereocilia are functional...
  44. Regulation of Apical-Basal Cell polarity during Intestinal Epithelial Morphogenes
    Nan Gao; Fiscal Year: 2013
    ..My long-term goal is to investigate the cell polarity regulators and their roles in the gastrointestinal morphogenesis and related diseases...
  45. Morphogenesis of mammalian gut endoderm
    Anna Katerina Hadjantonakis; Fiscal Year: 2012
    ..A rigorous understanding of normal gut endoderm morphogenesis, including knowledge of the origin, commitment, specification and differentiation of cells generating gut ..
  46. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    ..develop infection models in protozoa and in tap water to identify environmental conditions that promote cyst morphogenesis with sub aims of (i) tracking morphogenesis by light and electron microscopy;(i) by reporter gene fusions;(iii)..
  47. Mouse model for eyelid disease: Congenital blepharophimosis
    Chia Yang Liu; Fiscal Year: 2013
    ..and smooth muscle differentiation marker gene, alpha-smooth actin (a-SMA) expressions in POMCs during eyelid morphogenesis. Our preliminary studies allow us to propose the hypotheses that sustained Notch signaling disturbs the ..
  48. The role of the primitive choana in amniote craniofacial morphogenesis
    John Abramyan; Fiscal Year: 2013
    ..The presence of a new signalling center in the face will be investigated, and novel molecular causes for facial abnormalities such as cleft palate will be discovered. ..
  49. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2010
    ..b>Morphogenesis of the vertebrate head is particularly complex-it entails participation of multiple cell types, signaling ..
    Ina Dobrinski; Fiscal Year: 2013
    ..gene deletion through germ cell transplantation;3) to study the effects of the testicular microenvironment on morphogenesis and germ cell differentiation from pluripotent stem cells using xenografting of isolated testis cells;and 4) ..
  51. Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive Angiogenesis
    Steven Mentzer; Fiscal Year: 2013
    ..The goal of this project is the functional regulation of adult intussusceptive angiogenesis;that is, the rapid expansion of microvascular networks for application in both regenerative medicine and tissue engineering. ..
  52. Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and Behavior
    Grigorios Oikonomou; Fiscal Year: 2012
    ..To test the hypothesis that the LC provides cues that are sufficient to instruct Hcrt neuron morphogenesis, ectopic LC-like neurons will be generated...
  53. Regulation of tubulogenesis in the Drosophila ovary
    Celeste A Berg; Fiscal Year: 2012
    ..of the twk nubs phenotype and suggested that trimeric G-proteins participate in the regulation of tube morphogenesis. Surprisingly, mosaic analyses showed that G213F acts in a subset of leading cells to regulate the ..
  54. Transcriptional mechanisms of lower urinary tract development
    Gerald Mingin; Fiscal Year: 2013
    ..that the Six1-Eya1 transcriptional complex regulates expression of target genes that are required for the morphogenesis of the genitourinary structures...
  55. Smooth muscle adhesion and plasticity in coronary and outflow tract development
    Joan M Taylor; Fiscal Year: 2013
    ..In this proposal we seek to determine how FAK regulates SMC phenotype during vascular morphogenesis and to identify the precise mechanism(s) by which FAK and leupaxin alter SMC motility and differentiation...
  56. A Developmental And Molecular Investigation Of How Vitamin E Ameliorates Endocrin
    Krista McCoy; Fiscal Year: 2013
    ..ameliorative effects, and has two multifaceted specific aims 1) to investigate Vitamin E's effects on morphogenesis including cell invasion, proliferation, and apoptosis (cell death), 2) to investigate Vitamin E's ..
  57. Function of Microtubule Plus-End-Tracking Proteins in the Neuronal Growth Cone
    Laura Anne Lowery; Fiscal Year: 2013
    ..Supported by a pre-doctoral NRSA, she made significant progress defining the genes essential for early brain morphogenesis, including the identification of several genes required for normal neurogenesis and axon pathway formation...
  58. Regulation of Synapse Morphogenesis in Drosophila
    David L Van Vactor; Fiscal Year: 2013
    ..Our goal is to explore the molecular machinery that mediates synapse development and morphogenesis. This fundamental knowledge will be important for our understanding of neurological disease and for the ..
  59. Using shared mechanisms of morphogenesis to study neural tube defects
    DESCRIPTION (provided by applicant): Morphogenesis involves changes in cell shape regulated by complex networks that control cell polarity, cytoskeleton rearrangements and adhesive properties...
    ..We will define the role(s) of the C-terminal domain of p/rds in OS morphogenesis and stability and understand the physiological implications of binary (direct) protein binding to this domain...
  61. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2012
    ..The late stage of regeneration, morphogenesis, will be carefully analyzed using microCT scanning and histology...
  62. The Roles of Semaphorin Signaling During Valvuloseptal Development
    Kai Jiao; Fiscal Year: 2013
    ..of this study is to identify the molecular, cellular, and genetic mechanisms governing normal valvuloseptal morphogenesis and to reveal their contributions to CHDs...
  63. The role of the kimble gene in regulating craniofacial morphogenesis
    Daniel S Levic; Fiscal Year: 2013
    ..By exploring the function of this novel gene during craniofacial morphogenesis, this project identifies a new mechanism leading to chondrocyte cell death and cartilage degradation...
  64. Role of Angiogenesis in Distraction Osteogenesis
    ..Aim 1 will define the functional relationship between vessel morphogenesis and the induction of BMP2 in endothelial cells by altering vascular morphogenesis through blocking VEGFR 1 and ..
  65. Extracellular pH modulation by Candida albicans in vitro and in vivo
    Michael C Lorenz; Fiscal Year: 2013
    ..determine whether alkalinization occurs within the phagocyte and if this is the key signal that induces hyphal morphogenesis. Finally, we will use live cell imaging to dissect the intracellular trafficking of C...
  66. The roles of acidic autophagosomes in production of infectious poliovirus
    William T Jackson; Fiscal Year: 2013
    ..the roles played by autophagosomes during infection and define the mechanism by which PV induces autophagosome morphogenesis. Our preliminary data indicate that autophagy is required for optimal levels of infectious virus but is ..
  67. Epha/Ephrin - A Signaling in Epidermal Differentiation and Disease
    Spiro Getsios; Fiscal Year: 2013
    ..will be employed to define the reciprocal roles for EphA1 and EphA2 in epidermal differentiation and morphogenesis. We will test the innovative hypothesis that EphA1 and EphA2 exhibit discrete functions in keratinocyte ..
  68. A Model for Nephronophthisis in Caenorhabditis elegans
    Maureen M Barr; Fiscal Year: 2013
    ..In C. elegans, NPHP-1 and NPHP-4 act globally to modulate ciliary development and morphogenesis in a cell-type specific manner...
  69. Mandibular Cartilage Regeneration In Situ by Endogenous Stem Cell Recruitment
    Wendy S Vanden Berg-Foels; Fiscal Year: 2013
    ..Successful healing in adults, such as bone healing, recapitulates tissue morphogenesis and is orchestrated by a cascade of growth factors that induce chemotaxis, proliferation, and differentiation ..
  70. Lipid Signaling in Chemotaxis
    Miho Iijima; Fiscal Year: 2013 important for a variety of physiological events such as axon guidance, wound healing, and tissue morphogenesis. Inappropriate chemotaxis leads to many human diseases including tumor metastasis, asthma, arthritis and ..
  71. Studying Mitosis using Xenopus Egg Extracts
    Rebecca W Heald; Fiscal Year: 2013
    ..interactions, biophysical assays, and time-lapse fluorescence microscopy to study chromosome and microtubule morphogenesis at high resolution...
  72. Regulation of Endothelial Cell Branching Morphogenesis via MCAK-targted Control
    KENNETH ALBERT MYERS; Fiscal Year: 2013
    ..morphology, and will then determine how cell engagement of 2D and 3D collagen ECMs target and regulate MCAK via myosinII-dependent and -independent pathways to drive productive EC branching morphogenesis and directed migration.
  73. The role of MID1/MID2 in regulating epithelial adhesion
    CATHERINE KOTO; Fiscal Year: 2013
    ..the MID1 and MID2 control of epithelial adhesion involves both localized regulation of PP2A activity and the interaction with the PLEKHA proteins, as well as the importance of both MID proteins in the orchestration of lip morphogenesis.
  74. Activity-dependent microRNA expression and function in the mature nervous system
    Karl H Obrietan; Fiscal Year: 2013
    ..mammalian central nervous system, results from dicer null mice support a role for microRNAs in neuronal morphogenesis and neuronal survival...
  75. Screen for mutations affecting skull and suture formation in zebrafish
    Shannon Fisher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The closure of cranial sutures is a key process during skull morphogenesis. At the edges of the flat bones, which are centers of regulated bone formation, fibrous sutures unite the individual bones...
  76. Architecture of a Genetic Network Governing Morphogenesis
    David H A Fitch; Fiscal Year: 2013
    Cellular morphogenesis is an essential part of animal development and growth. During this process, cells coordinately change shape, migrate, and may fuse. These processes are executed by molecules called "effectors"...
  77. Hepatitis C Virus-Induced Liver Pathogenesis
    Aleem Siddiqui; Fiscal Year: 2013
    ..from several laboratories indicates role of cellular lipid/fatty acid synthetic pathways in viral replication, morphogenesis and secretion processes...
  78. Biophysical Mechanisms of Drosophila Development.
    Jennifer A Zallen; Fiscal Year: 2013
    ..been shown to influence many aspects of tissue development, including blood vessel remodeling, lung branching morphogenesis, and development of the heart, kidney, mammary gland, and bone...
  79. Ethanol-induced Lower Jaw Loss in Bmp Signaling Pathway Mutants
    CHARLES BENJAMIN LOVELY; Fiscal Year: 2013
    ..Complex interactions between neural crest cells and epithelial tissues are important for craniofacial morphogenesis. These interactions are orchestrated by, among others, the Bone Morphogenic Protein (Bmp) signaling pathway...
  80. Uncovering mechanisms controlling notochord vacuole and spine morphogenesis
    Michel Bagnat; Fiscal Year: 2013
    ..elongation during embryonic development and identified a novel role for this fluid filled organelle in spine morphogenesis. We found that loss of vacuole integrity leads to kinks in the spine axis similar to those observed in ..
  81. Mechanisms of Cell Polarity Establishment
    Ian G Macara; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Par polarity proteins are of profound importance to the morphogenesis of all metazoans, and defects in polarity are associated with cancer...
  82. Identifying genes required for digestive physiology and lipid metabolism
    Steven A Farber; Fiscal Year: 2013
    ..As a result, the dynamic regulatory signals that coordinate absorption and transport of fatty acids (FA), and morphogenesis and fat storage in adipose tissues, remain unclear...
    Sanjay Jain; Fiscal Year: 2013
    ..and then identify the key signaling cascades that are important for Ret's function in kidney branching morphogenesis and nephrogenesis...
  84. The ILK/PINCH/Parvin complex in renal tubulogenesis
    Roy Zent; Fiscal Year: 2013
    ..The renal papilla and CDs develop by undergoing iterative branching morphogenesis, a complex process that is, at least in part, dependent on cell-ECM interactions...
  85. Molecular Mechanism of Hepatocyte Growth Factor Signaling
    Po Han Chen; Fiscal Year: 2013
    ..In human, HGF and MET play pivotal roles in embryonic development, morphogenesis, tissue repair, and progression of malignancy...
  86. Analysis of retina rod photoreceptor GARP and cGMP-gated channel
    Steven J Pittler; Fiscal Year: 2013
    ..perturbations establishing in vivo that these proteins are necessary for normal rod outer segment ROS disk morphogenesis and structural integrity...
    Jianming Hu; Fiscal Year: 2013
    ..packaged host CDK2 in NC uncoating and infection;and (3) determine the mechanisms of regulation of HBV virion morphogenesis. Novel and specific models regarding HBV protein priming, NC uncoating, and virion formation will be tested...
  88. Genome packaging in DNA viruses
    Liang Tang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Genome packaging is a key step in morphogenesis of large double-stranded DNA (dsDNA) viruses including tailed double-stranded DNA bacteriophages and herpesviruses, and is essential for assembly of ..
  89. Molecular Patterning of Mammalian Dentition
    Rulang Jiang; Fiscal Year: 2013
    ..of odontogenic potential in the neural crest-derived tooth mesenchyme, which is responsible for driving tooth morphogenesis from the tooth bud stage and is sufficient to induce tooth organogenesis when recombined with non-dental ..
  90. Tooth Root Formation: An Emerging Signaling Pathway
    Jian Q Feng; Fiscal Year: 2013 applicant): Despite the advances made in identifying the signaling pathways in tooth germ and crown morphogenesis, the precise molecular events leading to root formation are largely unknown...
  91. Role of CLASP in neuronal morphogenesis during development
    Fengquan Zhou; Fiscal Year: 2013
    Neuronal morphogenesis is a highly regulated process that ultimately depends on the remodeling of neuronal cytoskeleton in response to extracellular cues...
  92. Mother Centriole Appendages Regulate the AMIS Compartment and Cilogenesis.
    Heidi Hehnly; Fiscal Year: 2013
    ..Polarized cells use the primary cilium as a versatile tool for tissue-specific functions during development, morphogenesis and homeostasis, explaining why cilia/polarity-related disorders (ciliopathies) can affect many organ systems...
  93. Investigate the multifunctional adhesins in Cryptococcus
    Xiaorong Lin; Fiscal Year: 2013 recently discovered that the transcription factor Znf2 serves as the molecular link between morphogenesis and virulence. Znf2 dictates cell adhesion, filamentation, and sporulation...
  94. ARF GTPase regulation of prostate tumorigenesis: spheroid and in vivo approaches
    DAVID MICHAEL BRYANT; Fiscal Year: 2013
    ..prostate epithelial cells to define changes in ARF regulome expression that control prostate acinar morphogenesis (Aim 1)...
  95. Regulation of Morphogenesis in C. albicans
    James B Konopka; Fiscal Year: 2013
    ..This essential barrier mediates secretion of virulence factors, morphogenesis, cell wall synthesis, and interfaces with the extracellular environment...
  96. Rho GTPases and polarity signaling pathways in morphogenesis and migration
    Alan Hall; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The signal transduction pathways driving morphogenesis and migration are still not well understood, yet defects in these processes underlie a wide spectrum of human diseases and syndromes, including ..
  97. A Novel Role of Syntaxin 3 as a Transcription Regulator
    Thomas Weimbs; Fiscal Year: 2013
    ..ETV4 is required for branching morphogenesis in kidney development, and associated with carcinogenesis and tumor metastasis...
    Richard M Harland; Fiscal Year: 2013
    ..oligonucleotides have provided insights into the mechanisms that underlie tissue differentiation and morphogenesis. During previous grant periods, we have used expression cloning to identify potent signaling and signal ..
  99. Mechanism of vertebrate neural tube morphogenesis
    John B Wallingford; Fiscal Year: 2013
    ..Recent data demonstrate additional requirements for Shroom3 in epithelial morphogenesis of the eye and the gut. Studies in humans link Shroom3 to renal disease and hypertension...
    GREGORY LONGMORE; Fiscal Year: 2013
    ..Over the past 3 years we have been studying the role of Rho GTPases in epithelial remodeling and morphogenesis in Drosophila...
  101. ATP-Dependent Chromatin Regulation in Neurodevelopment and Human Disease
    Gerald R Crabtree; Fiscal Year: 2013
    ..the proteins that bind to the neuron- specific surfaces of the complexes that mediate their role in dendritic morphogenesis, dendritic targeting and neural fate determination...