cell survival


Summary: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

Top Publications

  1. ncbi The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    Tiffany M Phillips
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 98:1777-85. 2006
  2. pmc Autophagy fights disease through cellular self-digestion
    Noboru Mizushima
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Nature 451:1069-75. 2008
  3. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
  4. pmc AKT/PKB signaling: navigating downstream
    Brendan D Manning
    Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2 117, Boston, MA 02115, USA
    Cell 129:1261-74. 2007
  5. ncbi Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    A Brunet
    Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:857-68. 1999
  6. ncbi In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    Lyubomir T Vassilev
    Department of Discovery Oncology, Roche Research Center, Hoffmann La Roche, Inc, Nutley, NJ 07110, USA
    Science 303:844-8. 2004
  7. ncbi Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    Hannah Farmer
    Cancer Research UK Gene Function and Regulation Group, London, UK
    Nature 434:917-21. 2005
  8. ncbi Hypoxia--a key regulatory factor in tumour growth
    Adrian L Harris
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Rev Cancer 2:38-47. 2002
  9. ncbi Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    Dos D Sarbassov
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell 22:159-68. 2006
  10. ncbi Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Pharmacol Toxicol 47:89-116. 2007

Detail Information

Publications337 found, 100 shown here

  1. ncbi The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    Tiffany M Phillips
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 98:1777-85. 2006
    ..Cancer-initiating cells can now be prospectively isolated from breast cancer cell lines and tumor samples and propagated as mammospheres in vitro under serum-free conditions...
  2. pmc Autophagy fights disease through cellular self-digestion
    Noboru Mizushima
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Nature 451:1069-75. 2008
    ..Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health...
  3. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
    ..This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases...
  4. pmc AKT/PKB signaling: navigating downstream
    Brendan D Manning
    Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2 117, Boston, MA 02115, USA
    Cell 129:1261-74. 2007
    ..In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration.
  5. ncbi Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    A Brunet
    Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:857-68. 1999
    ..Within the nucleus, FKHRL1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene...
  6. ncbi In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    Lyubomir T Vassilev
    Department of Discovery Oncology, Roche Research Center, Hoffmann La Roche, Inc, Nutley, NJ 07110, USA
    Science 303:844-8. 2004
    ..These compounds bind MDM2 in the p53-binding pocket and activate the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice...
  7. ncbi Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    Hannah Farmer
    Cancer Research UK Gene Function and Regulation Group, London, UK
    Nature 434:917-21. 2005
    ..These results illustrate how different pathways cooperate to repair damage, and suggest that the targeted inhibition of particular DNA repair pathways may allow the design of specific and less toxic therapies for cancer...
  8. ncbi Hypoxia--a key regulatory factor in tumour growth
    Adrian L Harris
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Rev Cancer 2:38-47. 2002
    ..Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting...
  9. ncbi Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    Dos D Sarbassov
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell 22:159-68. 2006
    ..mTORC2 phosphorylates and activates Akt/PKB, a key regulator of cell survival. Here we show that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolonged rapamycin ..
  10. ncbi Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Pharmacol Toxicol 47:89-116. 2007
    ..to the nucleus, and transactivates the expression of several dozen cytoprotective genes that enhance cell survival. This review highlights the key elements in this adaptive response to protection against acute and chronic ..
  11. pmc Autophagy in cell death: an innocent convict?
    Beth Levine
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 115:2679-88. 2005
    ..This review summarizes the evidence linking autophagy to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-..
  12. ncbi TSC2 mediates cellular energy response to control cell growth and survival
    Ken Inoki
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 115:577-90. 2003
    ..These observations demonstrate a model where TSC2 functions as a key player in regulation of the common mTOR pathway of protein synthesis, cell growth, and viability in response to cellular energy levels...
  13. ncbi Integrin-regulated FAK-Src signaling in normal and cancer cells
    Satyajit K Mitra
    The Scripps Research Institute, Department of Immunology, IMM21 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 18:516-23. 2006
    ..Activated FAK-Src functions to promote cell motility, cell cycle progression and cell survival. Recent studies have found that the FAK-Src complex is activated in many tumor cells and generates signals ..
  14. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
    ..These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity...
  15. pmc HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    Nicolas Chomont
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal Saint Luc, Montreal, Quebec, Canada
    Nat Med 15:893-900. 2009
    ..This reservoir is maintained through T cell survival and low-level antigen-driven proliferation and is slowly depleted with time...
  16. pmc Autophagy is activated for cell survival after endoplasmic reticulum stress
    Maiko Ogata
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Mol Cell Biol 26:9220-31. 2006
    ..Disturbance of autophagy rendered cells vulnerable to ER stress, suggesting that autophagy plays important roles in cell survival after ER stress.
  17. pmc Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cancer Cell 10:51-64. 2006
    ..Thus, autophagy may function in tumor suppression by mitigating metabolic stress and, in concert with apoptosis, by preventing death by necrosis...
  18. ncbi A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    I Nicoletti
    Istituto di Clinica Medica 1, Perugia University School of Medicine, Italy
    J Immunol Methods 139:271-9. 1991
    ..This new rapid, simple and reproducible method should prove useful for assessing apoptosis of specific cell populations in heterogeneous tissues such as bone marrow, thymus and lymph nodes...
  19. pmc AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    Sang Min Jeon
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Nature 485:661-5. 2012
    ..Here we show that AMPK activation, during energy stress, prolongs cell survival by redox regulation...
  20. ncbi Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    Geert J P L Kops
    Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, 3584 CG Utrecht, The Netherlands
    Nature 419:316-21. 2002
    ..The model of Forkhead involvement in regulating longevity stems from genetic analysis in Caenorhabditis elegans, and we conclude that this model also extends to mammalian systems...
  21. ncbi MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN
    Hua Yang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Cancer Res 68:425-33. 2008
    ..Significantly, miR-214 induces cell survival and cisplatin resistance through targeting the 3'-untranslated region (UTR) of the PTEN, which leads to down-..
  22. ncbi Cytotoxicity and genotoxicity of silver nanoparticles in human cells
    P V AshaRani
    Department of Chemistry, Faculty of Science, National University of Singapore, Singapore 117543, Singapore 117597
    ACS Nano 3:279-90. 2009
    ..The higher sensitivity of U251 cells and their arrest in G(2)/M phase could be explored further for evaluating the potential use of Ag-np in cancer therapy...
  23. pmc Role of autophagy in cancer
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nat Rev Cancer 7:961-7. 2007
    ..Recent evidence suggests that autophagy provides a protective function to limit tumour necrosis and inflammation, and to mitigate genome damage in tumour cells in response to metabolic stress...
  24. ncbi Proliferation, cell cycle and apoptosis in cancer
    G I Evan
    UCSF Cancer Center, 2340 Sutter Street, San Francisco, California 94143-0875, USA
    Nature 411:342-8. 2001
    ..Adroit targeting of these critical events should have potent and specific therapeutic consequences...
  25. ncbi A ROCK inhibitor permits survival of dissociated human embryonic stem cells
    Kiichi Watanabe
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Nat Biotechnol 25:681-6. 2007
    ..We demonstrate that the protective ability of Y-27632 enables SFEB-cultured hES cells to survive and differentiate into Bf1(+) cortical and basal telencephalic progenitors, as do SFEB-cultured mouse ES cells...
  26. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated...
  27. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004
    NF-kappaB is responsible for upregulating gene products that control cell survival. In this study, we demonstrate that SIRT1, a nicotinamide adenosine dinucleotide-dependent histone deacetylase, regulates the transcriptional activity of ..
  28. pmc Redox regulation of cell survival
    Dunyaporn Trachootham
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Antioxid Redox Signal 10:1343-74. 2008
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals to promote cell proliferation and survival, whereas ..
  29. ncbi Negative control of p53 by Sir2alpha promotes cell survival under stress
    J Luo
    Institute of Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cell 107:137-48. 2001
    ..These results have significant implications regarding an important role for Sir2alpha in modulating the sensitivity of cells in p53-dependent apoptotic response and the possible effect in cancer therapy...
  30. ncbi Cellular survival: a play in three Akts
    S R Datta
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA
    Genes Dev 13:2905-27. 1999
  31. ncbi FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    Zuzana Tothova
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:325-39. 2007
    ..Thus, FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential...
  32. ncbi Autophagy and signaling: their role in cell survival and cell death
    P Codogno
    1INSERM U504, Glycobiologie et Signalisation Cellulaire, Institut Andre Lwoff, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Cell Death Differ 12:1509-18. 2005
    ..Macroautophagy is activated by signaling pathways that also control apoptosis. The aim of this review is to discuss the signaling pathways that control macroautophagy during cell survival and cell death.
  33. ncbi Cellular response to oxidative stress: signaling for suicide and survival
    Jennifer L Martindale
    Cell Stress and Aging Section, Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, Maryland, USA
    J Cell Physiol 192:1-15. 2002
    ..stress in mammalian cells, the mechanisms leading to their activation, and their roles in influencing cell survival. These pathways constitute important avenues for therapeutic interventions aimed at limiting oxidative damage ..
  34. ncbi TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    Karim Bensaad
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Cell 126:107-20. 2006
    ..The decrease of intracellular ROS levels in response to TIGAR may also play a role in the ability of p53 to protect from the accumulation of genomic damage...
  35. ncbi Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    Melissa R Junttila
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    FASEB J 22:954-65. 2008
    ..In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation)...
  36. ncbi Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    V Stambolic
    Amgen Institute, and Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Cell 95:29-39. 1998
    ..by constitutively elevated activity and phosphorylation of protein kinase B/Akt, a crucial regulator of cell survival. Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist-induced apoptosis and ..
  37. pmc Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    Giulia Bertolini
    Molecular Cytogenetics Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 106:16281-6. 2009
    ..The molecular features of these cells may provide the rationale for more specific therapeutic targeting and the definition of predictive factors in clinical management of this lethal disease...
  38. pmc A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
    Jennifer M Burns
    ChemoCentryx, Inc, Mountain View, CA 94043, USA
    J Exp Med 203:2201-13. 2006
    ..Consistent with a role for CXCR7 in cell survival and adhesion, a specific, high affinity small molecule antagonist to CXCR7 impedes in vivo tumor growth in ..
  39. pmc New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    L C Cantley
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:4240-5. 1999
    ..PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides...
  40. ncbi AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
    Russell G Jones
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 18:283-93. 2005
    ..However, persistent activation of AMPK leads to accelerated p53-dependent cellular senescence. Thus, AMPK is a cell-intrinsic regulator of the cell cycle that coordinates cellular proliferation with carbon source availability...
  41. pmc Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer
    Kevin N Dalby
    Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA
    Autophagy 6:322-9. 2010
    ..In addition, autophagy seems to function as a protective cell survival mechanism against environmental and cellular stress (e.g...
  42. ncbi Cellular processing of platinum anticancer drugs
    Dong Wang
    Department of Chemistry, Massachusetts Institute of Technology, Room 18 498, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Rev Drug Discov 4:307-20. 2005
    ..Such knowledge of the cellular processing of cisplatin adducts with DNA provides valuable clues for the rational design of more efficient platinum-based drugs as well as the development of new therapeutic strategies...
  43. pmc Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    Zhizhong Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:501-13. 2009
    ..Our results demonstrate that GSCs differentially respond to hypoxia with distinct HIF induction patterns, and HIF2alpha might represent a promising target for antiglioblastoma therapies...
  44. pmc Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    David A Barbie
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115 USA
    Nature 462:108-12. 2009
    ..These observations indicate that TBK1 and NF-kappaB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer...
  45. pmc IRE1 signaling affects cell fate during the unfolded protein response
    Jonathan H Lin
    Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA 94158, USA
    Science 318:944-9. 2007
    ..The three UPR branches (IRE1, PERK, and ATF6) promote cell survival by reducing misfolded protein levels...
  46. ncbi Size-dependent cytotoxicity of gold nanoparticles
    Yu Pan
    Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Small 3:1941-9. 2007
    ..The cellular response is size dependent, in that 1.4-nm particles cause predominantly rapid cell death by necrosis within 12 h while closely related particles 1.2 nm in diameter effect predominantly programmed cell death by apoptosis...
  47. ncbi MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta
    Yoshiyuki Tsukamoto
    Department of Molecular Pathology, Faculty of Medicine and Institute of Scientific Research, Oita University, Oita, Japan
    Cancer Res 70:2339-49. 2010
    ..Taken together, we propose that miR-375 is a candidate tumor suppressor miRNA in gastric carcinoma...
  48. ncbi HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    Jung whan Kim
    Graduate Program of Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Metab 3:177-85. 2006
    ..These studies reveal a hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production...
  49. ncbi Mechanisms of cancer drug resistance
    Michael M Gottesman
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892 4255, USA
    Annu Rev Med 53:615-27. 2002
    ..Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs...
  50. pmc DNA methylation screening identifies driver epigenetic events of cancer cell survival
    Daniel D De Carvalho
    Department of Urology, Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9181, USA
    Cancer Cell 21:655-67. 2012
    ..We further showed experimentally that these genes must be silenced by DNA methylation for cancer cell survival, suggesting these are key epigenetic events associated with tumorigenesis.
  51. ncbi Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
    Ulrich Maurer
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Mol Cell 21:749-60. 2006
    ..The results demonstrate that the control of MCL-1 stability by GSK-3 is an important mechanism for the regulation of apoptosis by growth factors, PI3K, and AKT...
  52. ncbi The glamour and gloom of glycogen synthase kinase-3
    Richard S Jope
    Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Trends Biochem Sci 29:95-102. 2004
    ..Therefore, much effort is currently directed towards understanding the functions and control of GSK3, and identifying methods capable of diminishing the deleterious impact of GSK3 in pathological conditions...
  53. ncbi Perk is essential for translational regulation and cell survival during the unfolded protein response
    H P Harding
    Department of Medicine, The Kaplan Cancer Center, New York University School of Medicine, New York 10016, USA
    Mol Cell 5:897-904. 2000
    ..PERK thus plays a major role in the ability of cells to adapt to ER stress...
  54. ncbi Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    Li Liu
    Department of Cancer Biology, Bayer HealthCare Pharmaceuticals, West Haven, Connecticut 06516, USA
    Cancer Res 66:11851-8. 2006
  55. ncbi Autophagy: dual roles in life and death?
    Eric H Baehrecke
    Eric H Baehrecke is at the Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Nat Rev Mol Cell Biol 6:505-10. 2005
    ..conserved mechanism for the degradation of cellular components in the cytoplasm, and serves as a cell survival mechanism in starving cells...
  56. ncbi Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    K P Hoeflich
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Nature 406:86-90. 2000
    ..Thus, GSK-3beta facilitates NF-kappaB function...
  57. ncbi Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
    Martin Schwickart
    Department of Physiological Chemistry, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 463:103-7. 2010
    ..Here we show that the deubiquitinase USP9X stabilizes MCL1 and thereby promotes cell survival. USP9X binds MCL1 and removes the Lys 48-linked polyubiquitin chains that normally mark MCL1 for proteasomal ..
  58. doi Nanoparticle-mediated cellular response is size-dependent
    Wen Jiang
    Nat Nanotechnol 3:145-50. 2008
    ..The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity...
  59. pmc The double-edged sword of autophagy modulation in cancer
    Eileen White
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Clin Cancer Res 15:5308-16. 2009
    ..Autophagy is a tumor-suppression mechanism, yet it enables tumor cell survival in stress...
  60. pmc Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    Jessie Yanxiang Guo
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 25:460-70. 2011
    ..expression of a H-ras(V12) or K-ras(V12) oncogene up-regulates basal autophagy, which is required for tumor cell survival in starvation and in tumorigenesis...
  61. ncbi p53 regulates mitochondrial respiration
    Satoaki Matoba
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:1650-3. 2006
    ..That SCO2 couples p53 to mitochondrial respiration provides a possible explanation for the Warburg effect and offers new clues as to how p53 might affect aging and metabolism...
  62. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
    Neurotrophins are growth factors that promote cell survival, differentiation, and cell death. They are synthesized as proforms that can be cleaved intracellularly to release mature, secreted ligands...
  63. ncbi Translational control is required for the unfolded protein response and in vivo glucose homeostasis
    D Scheuner
    Howard Hughes Medical Institute, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA
    Mol Cell 7:1165-76. 2001
    ..The results demonstrate that regulation of translation through eIF2alpha phosphorylation is essential for the ER stress response and in vivo glucose homeostasis...
  64. ncbi Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
    Yutaka Matsui
    Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 100:914-22. 2007
    ..Furthermore, autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion...
  65. pmc A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    C Hirschmann-Jax
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital and Texas Children s Hospital, and DeBakey Department of Surgery, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:14228-33. 2004
  66. ncbi MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8
    L Fang
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Oncogene 30:806-21. 2011
    ..We found that miR-93 enhanced cell survival, promoted sphere formation and augmented tumor growth...
  67. ncbi Vascular niche for adult hippocampal neurogenesis
    T D Palmer
    Stanford University, Department of Neurosurgery, Palo Alto, California 94305, USA
    J Comp Neurol 425:479-94. 2000
    ..This environment may provide a novel interface where mesenchyme-derived cells and circulating factors influence plasticity in the adult central nervous system...
  68. ncbi Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability
    Karie N Dahlgren
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois 60201, USA
    J Biol Chem 277:32046-53. 2002
  69. ncbi Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    A Bonni
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 286:1358-62. 1999
    ..by which the Ras-mitogen-activated protein kinase (MAPK) signaling pathway mediates growth factor-dependent cell survival was characterized...
  70. pmc Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
    Kathrin Zaugg
    The Campbell Family Institute for Breast Cancer Research, University of Toronto, Toronto, Ontario, Canada
    Genes Dev 25:1041-51. 2011
    ..Our results indicate that cells can use a novel mechanism involving CPT1C and FA metabolism to protect against metabolic stress. CPT1C may thus be a new therapeutic target for the treatment of hypoxic tumors...
  71. pmc Nrf2 signaling and cell survival
    Suryakant K Niture
    Department of Pharmacology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Toxicol Appl Pharmacol 244:37-42. 2010
    ..combined with promoting an auto-regulatory loop between them regulates activation/deactivation of defensive genes leading to protection of cells against adverse effects of oxidative and electrophilic stress and promote cell survival.
  72. ncbi Docetaxel-albumin conjugates: preparation, in vitro evaluation and biodistribution studies
    Farnaz Esmaeili
    Novel Drug Delivery Systems Laboratory, Faculty of Pharmacy, Department of Pharmaceutics, Tehran University of Medical Sciences, PO Box 14155 6451, Tehran, Iran
    J Pharm Sci 98:2718-30. 2009
    ..4 +/- 1.75 nM. Conjugation also maintained DTX plasma level at 16.19% up to 2 h after injection compared with 2.51% for Taxotere, hence increasing the chance of nanoparticles uptake by tumor cells...
  73. ncbi Cytotoxicity of nanoparticles
    Nastassja Lewinski
    Department of Bioengineering MS 142, Rice University, PO Box 1892, Houston, TX 77251 1892, USA
    Small 4:26-49. 2008
  74. ncbi Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
    H A Cameron
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 USA
    J Comp Neurol 435:406-17. 2001
    ..1991] Anat Rec 231:482-497; Mulders et al. [1997] J Comp Neurol 385:83-94). The large number of the adult-generated granule cells supports the idea that these new neurons play an important role in hippocampal function...
  75. pmc Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
    Francesco Paolo Di Giorgio
    The Stowers Medical Institute, the Harvard Stem Cell Institute Harvard University, 7 Divinity Ave, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 10:608-14. 2007
    ..These phenotypes displayed in culture could provide cell-based assays for the identification of new ALS drugs...
  76. ncbi Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction
    Leopoldo Petreanu
    The Rockefeller University, New York, New York 10021, USA
    J Neurosci 22:6106-13. 2002
    ..This selection mechanism might allow the construction of specific OB circuits based on olfactory experience and suggests possible functions of OB cell replacement...
  77. pmc Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment
    Ubaldo E Martinez-Outschoorn
    Department of Medical Oncology and The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:3515-33. 2010
    ..How does the loss of stromal Cav-1 and the induction of stromal autophagy affect cancer cell survival? Interestingly, we show that a loss of Cav-1 in stromal fibroblasts protects adjacent cancer cells against ..
  78. ncbi Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
    Claudia Scholl
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:821-34. 2009
  79. ncbi AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
  80. ncbi The Bcl-2 family: roles in cell survival and oncogenesis
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Oncogene 22:8590-607. 2003
    ..Finally, it discusses the promise of novel anticancer therapeutics that target these vital regulators...
  81. ncbi Apoptosis and melanoma chemoresistance
    Maria S Soengas
    Department of Dermatology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 28109, USA
    Oncogene 22:3138-51. 2003
    ..With this knowledge in hand, the challenge is now to devise strategies potent enough to compensate or bypass these cell death defects and improve the actual poor prognosis of patients at late stages of the disease...
  82. ncbi MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2
    Tatiana Shatseva
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
    J Cell Sci 124:2826-36. 2011
    ..Our findings suggest that MiR-199a-3p targeting of caveolin-2 might have an important role in breast cancer tumor progression, making it a potential candidate for intervention in cancer...
  83. ncbi Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    H P Gerber
    Department of Cardiovascular Research, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 273:30336-43. 1998
    ..and the PI3-kinase/Akt signal transduction pathway as crucial elements in the processes leading to endothelial cell survival induced by VEGF...
  84. pmc A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival
    Anurag Singh
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94306, USA
    Cancer Cell 15:489-500. 2009
    ..These findings indicate that epithelial differentiation and tumor cell viability are associated, and that EMT regulators in "K-Ras-addicted" cancers represent candidate therapeutic targets...
  85. ncbi PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
    M A Lawlor
    MRC Protein Phosphorylation Unit, Department of Life Sciences, University of Dundee, UK
    J Cell Sci 114:2903-10. 2001
    ..There are, however, a number of pitfalls of methodologies currently employed to study PKB function, and therefore caution should be used in interpretation of such experiments...
  86. ncbi Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
    T Kanzawa
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cell Death Differ 11:448-57. 2004
    ..Application of an autophagy inhibitor that works after the association of LC3 with autophagosome membrane, such as bafilomycin A1, is expected to enhance the cytotoxicity of TMZ for malignant gliomas...
  87. pmc PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2281-92. 2006
  88. pmc Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
    Sara B Cullinan
    The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Department of Cancer Biology, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:7198-209. 2003
    ..PERK function is essential for cell survival following exposure of cells to ER stress, but the mechanisms whereby PERK signaling promotes cell survival are ..
  89. ncbi Akt enhances Mdm2-mediated ubiquitination and degradation of p53
    Yoko Ogawara
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 277:21843-50. 2002
    ..This study may shed light on the mechanisms by which Akt promotes survival, proliferation, and tumorigenesis...
  90. pmc Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability
    Wen Xing Ding
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15231, USA
    Am J Pathol 171:513-24. 2007
    ..Our studies thus provide a mechanistic view and elucidate the functional significance of the link between the two protein degradation systems...
  91. ncbi Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 109:707-18. 2002
    ..This linkage helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well-known treatment resistance of melanoma...
  92. ncbi Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
    Toshiyuki Araki
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 305:1010-3. 2004
    ..These findings suggest that novel therapeutic strategies directed at increasing the supply of NAD and/or Sir2 activation may be effective for treatment of diseases characterized by axonopathy and neurodegeneration...
  93. ncbi cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    Mathieu J M Bertrand
    Montreal Neurological Institute, McGill University, Montreal, Quebec H3A2B4, Canada
    Mol Cell 30:689-700. 2008
    The inhibitor of apoptosis (IAP) family of proteins enhances cell survival through mechanisms that remain uncertain...
  94. pmc Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    Makiko Nagai
    Department of Neurology, Columbia University, 710 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 10:615-22. 2007
    ..Identification of the astrocyte-derived soluble factor(s) may have far-reaching implications for ALS from both a pathogenic and therapeutic standpoint...
  95. ncbi Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    O Jameel Shah
    Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 14:1650-6. 2004
    ..Our results suggest that inappropriate activation of the Rheb/mTOR/S6K pathway imposes a negative feedback program to attenuate IRS-dependent processes such as cell survival.
  96. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
    ..These results have implications for the treatment of inflammatory and proliferative diseases...
  97. pmc p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
    H Christian Reinhardt
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18 580, Cambridge, MA 02139, USA
    Cancer Cell 11:175-89. 2007
    ..We show that the Chk1 inhibitor UCN-01 also potently inhibits MK2, suggesting that its clinical efficacy results from the simultaneous disruption of two critical checkpoint pathways in p53-defective cells...
  98. pmc Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
    Nat Immunol 10:176-84. 2009
    ..These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals...
  99. ncbi In vitro toxicity of nanoparticles in BRL 3A rat liver cells
    S M Hussain
    Applied Biotechnology, Air Force Research Laboratory HEPB, Wright Patterson AFB, OH, USA
    Toxicol In Vitro 19:975-83. 2005
  100. pmc Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction
    Nadine Wong Shi Kam
    Department of Chemistry and Laboratory for Advanced Materials, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:11600-5. 2005
    ..Thus, the transporting capabilities of carbon nanotubes combined with suitable functionalization chemistry and their intrinsic optical properties can lead to new classes of novel nanomaterials for drug delivery and cancer therapy...
  101. ncbi Enriched environments, experience-dependent plasticity and disorders of the nervous system
    Jess Nithianantharajah
    Howard Florey Institute, National Neuroscience Facility, University of Melbourne, Victoria 3010, Australia
    Nat Rev Neurosci 7:697-709. 2006
    ..Here, we review these findings on the environmental modulators of pathogenesis and gene-environment interactions in CNS disorders, and discuss their therapeutic implications...

Research Grants72

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..cleaved myofibrils (4-6) and nuclear matrix protein poly ADP-ribose polymerase (PARP)-a DNA repair enzyme in cell survival during I/R (7). However, the regulation of intracellular MMPs during I/R is not known...
  3. Xenoestrogen regulation of Leydig cells
    ..regulation of Leydig cell mitosis is mediated by interaction of signaling pathways, which involves the cell survival factor protein Akt (protein kinase B) acting in concert with estrogen receptor ER1, epidermal growth factor ..
  4. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..LPA and S1P regulate chemotaxis, stress responses, cytoskeletal organization, calcium signaling, cell survival, apoptosis, autophagy, and gene transcription...
  5. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Because of the pivotal role played by the mitochondria in the maintenance of cell survival and cardioprotection, it is logical that ethanol and age-associated increases in I/R injury might arise from ..
  6. Regulation of ER stress-induced cell death
    Randal J Kaufman; Fiscal Year: 2013
    ..The UPR is an adaptive signaling pathway to promote cell survival upon accumulation of unfolded protein in the endoplasmic reticulum (ER)...
  7. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..how sphingolipids interact with the PI3K/AKT pathway, a key membrane-localized signaling hub that regulates cell survival, protein synthesis, and autophagy and gene expression...
  8. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..proposal we outline studies that examine how MYCN, ODC, and polyamines regulate important cell cycle and cell survival pathways in NB cells...
  9. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Mitochondria play critical roles in cellular energy metabolism and in cell survival. A large number of diseases ranging from obesity, diabetes, heart failure and cancer are associated with ..
  10. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..Three major processes are involved in the pathogenesis of ACD. A slight shortening of red cell survival creates a demand for a small increase in red cell production by the bone marrow...
  11. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..and inactivating the Stat3 oncogenic signaling, associated with cyclin D1 (cell cycle) and Bcl-xL/Mcl-1 (cell survival) down regulation...
  12. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..We showed that JAK2 binds to PAK1 and makes PAK1 more active. Activated PAK1 contributes to better cell survival and cell migration...
  13. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..However, few studies have established a causal link between microfilament reorganization and cell survival. Villin is an actin regulatory protein expressed in the gastrointestinal epithelial cells of the small and ..
  14. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..INrf2 interaction with PGAM5/BclXL/Bcl2, HSP90, and pICln and its significance in cellular protection and cell survival/death...
  15. The role of IKK beta in cardiomyocytes at baseline and following stress
    MATTHEW PETER COGGINS; Fiscal Year: 2013
    ..transcription factors regulates a wide range of essential processes in multiple tissues, from inflammation to cell survival. In the heart, while it is known that NF-kB is involved in hypertrophy, ventricular remodeling, and ischemic ..
  16. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..Increased knowledge of how these enzymes regulate the balance between cell survival and cell death will promote innovative therapeutic development.
  17. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..FOXO1, one of the three FOXO homologs, regulates cell differentiation, promotes either cell survival or apoptosis;and also increases lifespan in model biologic systems...
    Cornelia M Weyand; Fiscal Year: 2012
    ..In Specific Aim 3, we will explore how competition for glucose affects CD4 T cell survival during priming...
  19. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    ..by focusing on four specific aims: First, we will identify the functional ethanol-dependent miRNAs involved in cell survival in human hepatic stellate cells, hepatocytes and cholangiocytes...
  20. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..The Nrf2 transcription factor regulates an integrated cell survival response that can be triggered by multiple classes of cancer chemopreventive agents (e.g...
  21. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..Collectively, these signals impact mitochondrial events critical to cell survival to limit necrotic and apoptotic cell death...
  22. Intracellular Serpin Regulation of Intestinal Cell Necrosis
    GARY ARTHUR SILVERMAN; Fiscal Year: 2012
    ..cysteine and serine peptidases, we hypothesized that they regulate intracellular proteolysis and enhance cell survival. This hypothesis was confirmed by showing that the C...
  23. Mouse models of genomic instability and birth defects
    ..Aim 3 will investigate the role of Acd in hematopoietic stem cell survival and maintenance...
  24. High throughput screen for selective inhibitors of cyclophilin B
    Richard J Bram; Fiscal Year: 2013
    ..by the identification of compounds that specifically target novel cellular proteins that contribute to tumr cell survival. The endoplasmic reticulum (ER) resident prolyl isomerase Cyclophilin B (CypB) is highly up-regulated in ..
  25. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
    ..the mere maintenance of telomere length, including regulation of cell differentiation, gene expression and cell survival/apoptosis...
  26. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
    ..substrate of ERK and can mediate many of the biological functions of the Ras/ERK MAP kinase pathway including cell survival, proliferation and transcription. RSKs are large kinases consisting of two kinase domains...
  27. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..high expression at early hepatic developmental stages that coincide with ongoing cell proliferation and cell survival. Blocking PDGFR[unreadable] in embryonic liver culture verified these effects thus warranting an in depth ..
  28. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..tested here are that bacterially-derived TLR agonists enhance RNA virus replication through i) activation of cell survival/proliferation pathways, or ii) suppression of antiviral pathways...
  29. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..Because insulin-like factors have recently been shown to support germ cell survival, I focused my initial studies on Rhox5 regulation of Ins2...
  30. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
    ..in VS cells results in persistent JNK activation which, in turn, suppresses accumulation of ROS, promotes cell survival, and confers radioresistance...
  31. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ..and interplay between HO and Cox signaling mechanisms in the vasculature are critical determinants of host cell survival, onset/degree of inflammation, and changes in vascular permeability, all of which are critical determinants of ..
  32. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    ..Assays will be performed to determine clonogenic cell survival, mitochondrial function, ROS production, mitochondrial DNA fragmentation and mode of cell death after ..
  33. The function of ATM protein in the biology of the adult neuron CNS:
    Karl Herrup; Fiscal Year: 2013
    ..Our outcome measures will include dendritic morphology, synaptic physiology, cell cycle regulation and cell survival. The second part of our strategy will be to develop strong pre-clinical platforms, both in vivo and in vitro, ..
  34. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..PTHrP which may be candidate targets for design of anticancer drugs and would ultimately limit cancer cell survival, growth, and spread...
  35. Regulation of apoptosis by PI 3-kinase/Akt signaling
    Geoffrey M Cooper; Fiscal Year: 2012
    ..The present proposal seeks to further understand the mechanism by which this pathway regulates cell survival. Discoveries of novel targets of PI 3-kinase signaling may provide new targets for cancer treatment...
  36. Respiration in Sepsis
    Claude A Piantadosi; Fiscal Year: 2013
    ..strategies to activate or inhibit AMPK independently of NOS2 regulate hepatic mitochondrial biogenesis and cell survival and lessen NO-dependent cell damage in sepsis. 2A...
    Sanjay Awasthi; Fiscal Year: 2011
    ..Rlip appears to be necessary for cancer cell survival because both in-vitro cell culture and animal tumor studies show that depletion or inhibition of Rlip causes ..
  38. Regulation of EBV Latency by EBNA1
    Paul M Lieberman; Fiscal Year: 2013
    ..EBNA1 is also required for host-cell survival. The molecular mechanisms for each of these functions are only partly understood, and more complete ..
  39. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2013
    ..such as tubulin and Akt suggest that this GRK may play roles in adaptive myocyte shape and size as well as cell survival. In addition, GRK2 can be found in/on mitochondria in cardiac myocytes through novel protein-protein ..
  40. New Molecular and Cellular Mechanisms of Glaucoma
    Andrei Surguchov; Fiscal Year: 2013
    ..of 3- synuclein involvement in glaucomatous changes we found that g-synuclein is a modulator of cell death/cell survival. This function is realized by modulating the level of phosphorylation of proapoptotic member of Bcl-2 family, ..
  41. Novel Diagnostics to Detect Lung Injury
    Elizabeth R Jacobs; Fiscal Year: 2013
    ..that: (i) IR stimulates mitochondrial complex I dysfunction which leads to subsequent apoptosis and decreased cell survival as detected biochemically and histologically (ii) SPECT/CT and optical imaging can detect and quantify ..
  42. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    ..is up-regulated in response to these changes and can lead to cellular depletion of NAD+ and ATP inhibiting cell survival pathways...
  43. Regulation of Human Papillomavirus Replication via Cell Signaling Pathways
    ANASTACIA GRIEGO; Fiscal Year: 2013
    ..results in increased EGFR signal transduction leading to enhanced viral transcription through modulation of cell survival and proliferation signals...
  44. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
    ..on activation of signal transducer and activator of transcription-3 (STAT3), a fundamental regulator of cell survival and angiogenesis...
  45. Developing a murine model for arsenic-induced skin neoplasm
    Mohammad Athar; Fiscal Year: 2010
    ..the role of arsenic-induced reactive oxygen species (ROS) and associated cell signaling related to stress and cell survival pathways as well as the possible additive or synergistic effects of ROS on shh in augmenting cell ..
    Steven G Clarke; Fiscal Year: 2013
    ..We will pay special attention to the human PRMT7 protein that has been implicated in tumor formation and stem cell survival. Our overall goal is to establish the complete cast of characters of the enzymes that catalyze these ..
  47. microRNA mediation of Endothelial Progenitor Cell function in Myocardial Ichemia
    Prasanna Krishnamurthy; Fiscal Year: 2013
    ..data from EPCs, in response to inflammatory stimuli, indicates an up-regulation of number of miRNAs related to cell survival/death and angiogenesis with a robust increase in miR-377, 3) myocardial infarction (MI) increased miR-377 ..
  48. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..FAK) is a cytoplasmic tyrosine kinase that is activated by integrins and hypothesized to regulate aspects of cell survival and motility during tumor progression...
  49. Studying a novel regulator of GBM tumorigeneis: the role of CK2alpha in maintaini
    Gordon Li; Fiscal Year: 2013
    ..of casein kinase 2 (CK2), a highly conserved pleiotropic serine/threonine kinase that has been associated with cell survival in many cancers...
  50. Role of Heat Shock Transcription Factor Hsf1 in Tumorigenesis
    Nahid F Mivechi; Fiscal Year: 2013
    ..has been observed in many human tumor types, and is considered to be an adaptive response to enhance tumor cell survival. Heat shock transcription factor 1 (Hsf1) is a major transactivator of Hsps and other molecular chaperones...
  51. The lymph node microenvionment in tumor metastasis
    Judith A Varner; Fiscal Year: 2012
    ..that integrin ?4?1 mediated signaling via Protein Kinase A, Raf and caspase 8 promote lymphatic endothelial cell survival during lymphangiogenesis and subsequent tumor metastasis;that lymph node lymphatic endothelium promotes the ..
  52. Deacetylation of mitochondrial proteins protect neurons from ischemic injury
    Conrad Alano; Fiscal Year: 2013
    ..Sirtuins are a family of NAD-dependent deacetylases that have been implicated in metabolism, cell survival mechanisms, and alteration of life span...
  53. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..to novel strategies to selectively block lymphocyte activation in autoimmune disease, and/or inhibit cancer cell survival. In this application, we propose to investigate a novel protein called Folliculin Interacting protein-1 (Fnip1)..
  54. Metnase, PIKK, and RPA Roles in DNA Damage and Replication Stress Responses
    Jac A Nickoloff; Fiscal Year: 2013
    ..DDR pathways determine cell fates in response to DNA damage, including cell survival, genome stability, and cell death/permanent growth arrest via apoptosis, autophagy, necrosis, senescence, or ..
  55. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..Understanding the regulatory signals governing beta cell survival is critical for devising strategies to maintain a healthy population of cells in individuals...
  56. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2012
    ..that guide germ cells and analyze the nature of the migratory response in germ cells and its role in germ cell survival. In the third aim, we propose to isolate a germ cell attractant produced by the somatic gonad, which we have ..
  57. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..TLR3 is expressed in all neurons examined, activation on cortical neurons or sensory neurons has no effect on cell survival. By contrast, activation of TLR3 results in selective loss of motor neurons in primary dissociated spinal cord ..
  58. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
    ..is characterized by the transcription of several viral genes associated with viral genome stability and host-cell survival. The major latency transcript is a multicistronic message that consists of the LANA, vCyclin, and vFLIP genes, ..
  59. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2013
    ..laboratories have provided novel mechanistic links between LRP-1-initiated cell-signaling and inflammation, cell survival, and atherosclerosis...
  60. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    ..To understand the molecular genetic basis of L functions in cell survival, specification and growth, we will use molecular genetics approaches commonly employed in Drosophila model ..
  61. Organismal Radioprotection Through Pharmacological Quiescence
    JOHN S CHANT; Fiscal Year: 2010
    ..As quiescent cells are resistant to IR, PQ enhances the per cell survival of HSPC by augmenting the repair of DNA damage post-TBI...
  62. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2013
    ..concentration controls many cellular functions including muscle contraction, neurotransmitter release, cell survival and growth. Calcium ion channels are important drug targets for hypertension and neuropathic pain...
  63. Alteration of ER:mitochondrial contacts by human cytomegalovirus infection
    ..Trafficking of UL37 proteins is central to the ordered events in the viral lytic cycle, host cell survival during infection, and the assembly of infectious progeny virus...
  64. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..initiates intracellular signals in endothelial cells that synergize with growth factor receptors to elicit cell survival and cell proliferation...
    Robert Strange; Fiscal Year: 2004
    ..Akt I activation is common to hormone, growth factor and anchorage mediated epithelial cell survival and Ha-rasinduced tumorigenesis...
  66. Novel Screen for Targeted CLL Therapeutics
    Dale Christensen; Fiscal Year: 2009
    ..have been shown to be due to inhibited apoptosis and alterations of genes involved in cell cycle control and cell survival. When evaluating the signaling pathways that are aberrantly activated in B-CLL cells, it was demonstrated that ..
  67. Lenalidomide Treatment and the Chronic Lymphocytic Leukemia Microenvironment
    Thomas J Kipps; Fiscal Year: 2010
    ..on the biology of CLL has revealed that accessory cells in the leukemia microenvironment can promote leukemia-cell survival and resistance to chemotherapy in vitro, and presumably in vivo...
  68. Cell Survival in Brain Reperfusion
    Jonathon Sullivan; Fiscal Year: 2004
    ..Growth factors such as insulin mediate cell survival through the kinase Akt, a downstream affector of the phosphatidylinositol-3 kinase (PI3K)...
  69. Cell Survival Pathways and Inhibitors in Leukemia
    Alan Eastman; Fiscal Year: 2003
    Tumors characteristically exhibit mutations that enhance cell proliferation and survival. Two well-recognized cell survival pathways are RAF to MEK to ERK and PI3-kinase to Akt...
  70. IGF binding protein-3 in beta cell apoptosis
    ROBERT FERRY JR; Fiscal Year: 2005
    ..Normal beta-cell survival entails complex regulation of multiple hormones and fundamental growth factors, including the insulin-like ..
  71. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2009
    ..In particular, insulin-like growth factor I (IGF-I) plays a major role in PaCa cell survival. We have found that reactive oxygen species (ROS) produced by NADPH oxidase mediate the pro-survival effect of ..
  72. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2005
    ..The normal cellular mechanisms regulating cell survival that are disrupted in these diseases are not well understood...