amino acid sequence homology
Summary: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Publications310 found, 100 shown here
- T-Coffee: A novel method for fast and accurate multiple sequence alignmentC Notredame
National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
J Mol Biol 302:205-17. 2000..The improvement, especially clear with the more difficult test cases, is always visible, regardless of the phylogenetic spread of the sequences in the tests...
- The HHpred interactive server for protein homology detection and structure predictionJohannes Söding
Department of Protein Evolution, Max Planck Institute for Developmental Biology Spemannstrasse 35, 72076 Tubingen, Germany
Nucleic Acids Res 33:W244-8. 2005..A detailed help facility is available. As a demonstration, we analyze the sequence of SpoVT, a transcriptional regulator from Bacillus subtilis. HHpred can be accessed at http://protevo.eb.tuebingen.mpg.de/hhpred...
- An efficient algorithm for large-scale detection of protein familiesA J Enright
Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
Nucleic Acids Res 30:1575-84. 2002..The method has been used to detect and categorise protein families within the draft human genome and the resulting families have been used to annotate a large proportion of human proteins...
- Protein homology detection by HMM-HMM comparisonJohannes Söding
Department of Protein Evolution, Max Planck Institute for Developmental Biology Spemannstrasse 35, D 72076 Tubingen, Germany
Bioinformatics 21:951-60. 2005..Protein homology detection and sequence alignment are at the basis of protein structure prediction, function prediction and evolution...
- The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprintsRobert Fredriksson
Department of Neuroscience, Biomedical Center, Box 593, 75 124 Uppsala, Sweden
Mol Pharmacol 63:1256-72. 2003..Our novel approach of analyzing such large and diverse sequence sets may be useful for studies on GPCRs in other genomes and divergent protein families...
- The complete genome sequence of Escherichia coli K-12F R Blattner
Laboratory of Genetics, University of Wisconsin Madison, 445 Henry Mall, Madison, WI 53706, USA
Science 277:1453-62. 1997..The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer...
- Protein database searches using compositionally adjusted substitution matricesStephen F Altschul
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
FEBS J 272:5101-9. 2005..In a typical database search, at least one of these criteria is satisfied by over half the related sequence pairs. Compositional substitution matrix adjustment is now available in NCBI's protein-protein version of blast...
- CLANS: a Java application for visualizing protein families based on pairwise similarityTancred Frickey
Max Planck Institut fuer Entwicklungsbiologie, Spemannstrasse 35, 72076 Tuebingen, Germany
Bioinformatics 20:3702-4. 2004..AVAILABILITY: CLANS can be downloaded at http://protevo.eb.tuebingen.mpg.de/download...
- Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signalingHiroshi Abe
Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
Plant Cell 15:63-78. 2003..These results indicate that both AtMYC2 and AtMYB2 proteins function as transcriptional activators in ABA-inducible gene expression under drought stress in plants...
- Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2J Gyuris
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
Cell 75:791-803. 1993..These experiments identify Cdi1 as a novel type of protein phosphatase that forms complexes with cyclin-dependent kinases...
- The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamiliesAlison L Cuff
Institute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK
Nucleic Acids Res 37:D310-4. 2009..Information on the degree of structural diversity in each superfamily and structural overlaps between superfamilies can now be downloaded from the CATH website...
- Flexible structure alignment by chaining aligned fragment pairs allowing twistsYuzhen Ye
Program in Bioinformatics and Systems Biology, The Burnham Institute, La Jolla, CA 92037, USA
Bioinformatics 19:ii246-55. 2003....
- Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinM Furuse
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
J Cell Biol 141:1539-50. 1998....
- PRALINE: a multiple sequence alignment toolbox that integrates homology-extended and secondary structure informationV A Simossis
Bioinformatics Section, Faculty of Sciences, Vrije Universiteit De Boelelaan 1081A, 1081 HV, Amsterdam, The Netherlands
Nucleic Acids Res 33:W289-94. 2005..The grouping of sequences, on which the alignment is based, can also be visualized as a dendrogram. PRALINE is available at http://ibivu.cs.vu.nl/programs/pralinewww/...
- OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groupsFeng Chen
Department of Chemistry, Center for Bioinformatics, Penn Genomics Institute, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
Nucleic Acids Res 34:D363-8. 2006..OrthoMCL-DB provides a centralized warehouse for orthology prediction among multiple species, and will be updated and expanded as additional genome sequence data become available...
- A brain serine/threonine protein kinase activated by Cdc42 and Rac1E Manser
Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
Nature 367:40-6. 1994..This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways...
- A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2R Mahajan
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Cell 88:97-107. 1997..Inhibition of nuclear protein import resulting from antibodies directed at NPC-associated RanGAP1 cannot be overcome by soluble cytosolic RanGAP1, indicating that GTP hydrolysis by Ran at RanBP2 is required for nuclear protein import...
- Common origin of four diverse families of large eukaryotic DNA virusesL M Iyer
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
J Virol 75:11720-34. 2001....
- Exportin 1 (Crm1p) is an essential nuclear export factorK Stade
Department of Biochemistry and Biophysics, University of California at San Francisco, 94143 0414, USA
Cell 90:1041-50. 1997..cerevisiae. The presented data are consistent with the conclusion that Crm1p is a carrier for the NES-mediated protein export pathway. We propose CRM1 be renamed exportin 1 (XPO1)...
- Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologuesTal Pupko
The Institute of Statistical Mathematics, 4 6 7 Minami Azabu, Minato ku, Tokyo 106 8569, Japan
Bioinformatics 18:S71-7. 2002..Functionally important regions often correspond to surface patches of slowly evolving residues...
- A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICADM Enari
Department of Genetics, Osaka University Medical School, Suita, Japan
Nature 391:43-50. 1998....
- Repression domains of class II ERF transcriptional repressors share an essential motif for active repressionM Ohta
Gene Discovery Research Center, National Institute of Advanced Industrial Science and Technology AIST, Central 6, Tsukuba 305 8566, Japan
Plant Cell 13:1959-68. 2001..These zinc finger proteins functioned as repressors, and their repression domains were identified as regions that contained an EAR motif...
- Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motilityM F Carlier
Dynamique du Cytosquelette, Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
J Cell Biol 136:1307-22. 1997..In conclusion, the function of ADF is not to sequester G-actin. ADF uses ATP hydrolysis in actin assembly to enhance filament dynamics...
- Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2G A Rouleau
Centre de recherche en Neuroscience, McGill University, Montreal, Quebec, Canada
Nature 363:515-21. 1993..Its deduced product has homology with proteins at the plasma membrane and cytoskeleton interface, a previously unknown site of action of tumour suppressor genes in humans...
- Using sequence similarity networks for visualization of relationships across diverse protein superfamiliesHolly J Atkinson
Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 4:e4345. 2009..As a broadly accessible and effective tool for the exploration of protein superfamilies, sequence similarity networks show great potential for generating testable hypotheses about protein structure-function relationships...
- Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersP A Steck
Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
Nat Genet 15:356-62. 1997..Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers...
- An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenesG N Filippova
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Mol Cell Biol 16:2802-13. 1996..e., c-myc) of different vertebrate species are regulated by the same factor and maintain similar expression patterns despite significant promoter sequence divergence...
- PISCES: a protein sequence culling serverGuoli Wang
Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Bioinformatics 19:1589-91. 2003..PDB sequences are updated weekly. PISCES can also cull non-PDB sequences provided by the user as a list of GenBank identifiers, a FASTA format file, or BLAST/PSI-BLAST output...
- PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodiaA Abo
Onyx Pharmaceuticals, 3031 Research Drive, Richmond, CA 94806, USA
EMBO J 17:6527-40. 1998..Thus, unlike other members of the PAK family, PAK4 provides a novel link between Cdc42Hs and the actin cytoskeleton. The cellular locations of PAK4 and Cdc42Hs suggest a role for the Golgi in cell morphogenesis...
- B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretionH Dong
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Nat Med 5:1365-9. 1999..Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses...
- Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans geneW G Kelly
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
Genetics 146:227-38. 1997..The resulting transgenes show robust expression in both germline and soma. Our results suggest the possibility of concerted mechanisms for silencing unwanted germiline expression of repetitive sequences...
- The Transporter Classification Database: recent advancesMilton H Saier
Division of Biological Sciences and Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA 92093 0116, USA
Nucleic Acids Res 37:D274-8. 2009..The availability of these tools has resulted in recognition of distant phylogenetic relationships and tremendous expansion of the information available to TCDB users...
- The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteinsM Rothe
Department of Molecular Biology Tularik, Incorporated, South San Francisco, California 94080, USA
Cell 83:1243-52. 1995..The recruitment of c-IAP1 or c-IAP2 to the TNFR2 signaling complex requires a TRAF2-TRAF1 heterocomplex...
- TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleusP Grüter
Department of Molecular Biology, University of Geneva, Switzerland
Mol Cell 1:649-59. 1998..Thus, TAP, like its yeast homolog Mex67p, is a bona fide mRNA nuclear export mediator. TAP is the second cellular RNA binding protein shown to be directly involved in the export of its target RNA...
- The Corynebacterium glutamicum genome: features and impacts on biotechnological processesM Ikeda
Tokyo Research Laboratories, Kyowa Hakko Kogyo, Asahi machi, Machida, 194 8533, Tokyo, Japan
Appl Microbiol Biotechnol 62:99-109. 2003..How can traditional fermentation benefit from the C. glutamicum genomic data? The path from genomics to biotechnological processes is presented...
- Cell transformation by the superoxide-generating oxidase Mox1Y A Suh
Department of Biochemistry, Emory University Medical School, Atlanta, Georgia 30322, USA
Nature 401:79-82. 1999..Cells expressing mox1 have a transformed appearance, show anchorage-independent growth and produce tumours in athymic mice. These data link ROS production by Mox1 to growth control in non-phagocytic cells...
- Cross-genome screening of novel sequence-specific non-LTR retrotransposons: various multicopy RNA genes and microsatellites are selected as targetsKenji K Kojima
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
Mol Biol Evol 21:207-17. 2004..This indicates that the copy number of a target sequence is the primary factor to restrict the variety of sequence specificity of LINEs...
- Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOSS Wang
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
Blood 96:2808-13. 2000..The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule. (Blood. 2000;96:2808-2813)..
- Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domainsM Yamabhai
Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
J Biol Chem 273:31401-7. 1998..We propose that Intersectin is a component of the endocytic machinery...
- A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewalD N Cox
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
Genes Dev 12:3715-27. 1998..Decreasing C. elegans piwi expression reduces the proliferation of GSC-equivalent cells. Thus, piwi represents a novel class of genes required for GSC division in diverse organisms...
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismT Kitada
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
Nature 392:605-8. 1998..Mutations in the newly identified gene appear to be responsible for the pathogenesis of AR-JP, and we have therefore named the protein product 'Parkin'...
- Prokaryotic origin of the actin cytoskeletonF van den Ent
MRC Laboratory of Molecular Biology, Cambridge, UK
Nature 413:39-44. 2001..Thus, prokaryotes are now known to possess homologues both of tubulin, namely FtsZ, and of actin...
- Intermediate filaments: structure, dynamics, function, and diseaseE Fuchs
Howard Hughes Medical Institute, University of Chicago, Illinois 60637
Annu Rev Biochem 63:345-82. 1994
- Ubiquitin-dependent protein degradationM Hochstrasser
Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
Annu Rev Genet 30:405-39. 1996..This diversity underlies both the high substrate specificity of the ubiquitin system and the variety of regulatory mechanisms that it serves...
- Convergent evolution: the need to be explicitR F Doolittle
Center for Molecular Genetics, University of California, San Diego, La Jolla 92093 0634
Trends Biochem Sci 19:15-8. 1994..Functional and mechanistic convergence are both common, and some structural convergence has probably occurred, but a convincing case for genuine sequence convergence has yet to be made...
- Regulation of chromatin structure by site-specific histone H3 methyltransferasesS Rea
Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
Nature 406:593-9. 2000..Our data reveal a functional interdependence of site-specific H3 tail modifications and suggest a dynamic mechanism for the regulation of higher-order chromatin...
- New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay systemVivek Anantharaman
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Genome Biol 4:R81. 2003..The RelE toxin cleaves ribosome-associated transcripts, whereas another post-segregational cell killing toxin, ParE, functions as a gyrase inhibitor...
- Combinatorial receptor codes for odorsB Malnic
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 96:713-23. 1999..Our studies also indicate that slight alterations in an odorant, or a change in its concentration, can change its "code," potentially explaining how such changes can alter perceived odor quality...
- OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28C Alexander
Department of Molecular Genetics, Insititute of Ophthalmology, University College London, London, UK
Nat Genet 26:211-5. 2000..The presence of consensus signal peptide sequences suggests that the product of the gene OPA1 is targeted to mitochondria and may exert its function in mitochondrial biogenesis and stabilization of mitochondrial membrane integrity...
- GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteinsE M Ross
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
Annu Rev Biochem 69:795-827. 2000..GAPs are regulated by various controls of their cellular concentrations, by complex interactions with G¿ or with G¿5 through an endogenous G-like domain, and by interaction with multiple other proteins...
- Bioinformatic analysis of the CLE signaling peptide familyKarsten Oelkers
School of Biochemistry and Molecular Biology, The Australian National University, Canberra, ACT, Australia
BMC Plant Biol 8:1. 2008....
- A candidate prostate cancer susceptibility gene at chromosome 17pS V Tavtigian
Myriad Genetics, Inc, Salt Lake City, Utah, USA
Nat Genet 27:172-80. 2001....
- Investigating the origins of triploblasty: 'mesodermal' gene expression in a diploblastic animal, the sea anemone Nematostella vectensis (phylum, Cnidaria; class, Anthozoa)Mark Q Martindale
Kewalo Marine Laboratory, Pacific Biomedical Research Center, University of Hawaii, 41 Ahui Street, Honolulu, HI 96813, USA
Development 131:2463-74. 2004..Alternatively, we consider the possibility that the diploblastic condition of cnidarians is a secondary simplification, derived from an ancestral condition of triploblasty...
- Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamicsF B Gertler
Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Cell 87:227-39. 1996..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
- A genome phylogeny for mitochondria among alpha-proteobacteria and a predominantly eubacterial ancestry of yeast nuclear genesChristian Esser
Institute of Botany III, University of Dusseldorf, Dusseldorf, Germany
Mol Biol Evol 21:1643-60. 2004..Among eubacteria and archaebacteria, proteobacterial and methanogen genomes, respectively, shared more similarity with the yeast genome than other prokaryotic genomes surveyed...
- The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processingW Jiang
Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
Nature 375:151-5. 1995..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
- Drosophila rhomboid-1 defines a family of putative intramembrane serine proteasesS Urban
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Cell 107:173-82. 2001..Rhomboid-1 is conserved throughout evolution from archaea to humans, and our results show that a human Rhomboid promotes Spitz cleavage by a similar mechanism. This growth factor activation mechanism may therefore be widespread...
- Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehydeMin Hu
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544, USA
Cell 111:1041-54. 2002..Binding by ubiquitin aldehyde induces a drastic conformational change in the active site that realigns the catalytic triad residues for catalysis...
- APC binds to the novel protein EB1L K Su
Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
Cancer Res 55:2972-7. 1995..This conservation suggests an essential function for EB1 that might provide clues to the mechanism through which APC suppresses colonic neoplasia...
- Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alphaM L Moss
Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
Nature 385:733-6. 1997..The rTACE provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of TNF-alpha production...
- fork head domain genes in zebrafishJ Odenthal
MPI für Entwicklungsbiologie, Spemannstrasse 35 III, D 72076 Tubingen, Germany
Dev Genes Evol 208:245-58. 1998..fkd6 is strongly expressed in neural crest cells from early stages on, whereas fkd2 and fkd7 are transcribed in individual neural crest cells in the pharyngula period...
- KIR: diverse, rapidly evolving receptors of innate and adaptive immunityCarlos Vilches
Servicio de Inmunologia, Hospital Universitario Clinica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain
Annu Rev Immunol 20:217-51. 2002..This diversity likely contributes variability to the function of NK cells and T-lymphocytes by modulating innate and adaptive immune responses to specific challenges...
- Two novel proteins activate superoxide generation by the NADPH oxidase NOX1Botond Banfi
Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, Switzerland
J Biol Chem 278:3510-3. 2003..In conclusion, NOX1 is a superoxide-generating enzyme that is activated by two novel proteins, which we propose to name NOXO1 (NOX organizer 1) and NOXA1 (NOX activator 1)...
- Whole proteome analysis of post-translational modifications: applications of mass-spectrometry for proteogenomic annotationNitin Gupta
Bioinformatics Program, University of California San Diego, La Jolla, California 92093, USA
Genome Res 17:1362-77. 2007..This study demonstrates that complementing every genome sequencing project by an MS/MS project would significantly improve both genome and proteome annotations for a reasonable cost...
- SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeletonFarhana Haque
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
Mol Cell Biol 26:3738-51. 2006..Our data provide evidence of a physical nuclear-cytoskeletal connection that is likely to be a key mechanism in nuclear-cytoplasmic communication and regulation of nuclear position...
- A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitroT Hirano
Department of Pharmacology, University of California, San Francisco 94143 0450
Cell 79:449-58. 1994..These motifs are highly conserved in a protein family, members of which have been identified recently in both prokaryotes and eukaryotes...
- A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxisT Yokomizo
Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Japan
Nature 387:620-4. 1997..Our findings, together with previous reports, show that LTB4 is a unique lipid mediator that interacts with both cell-surface and nuclear receptors...
- Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activityR A Frye
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15240, USA
Biochem Biophys Res Commun 260:273-9. 1999..These results suggest that the sirtuins may function via mono-ADP-ribosylation of proteins...
- The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6T Serafini
Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452
Cell 78:409-24. 1994..elegans. This homology suggests that growth cones in the vertebrate spinal cord and the nematode are responsive to similar molecular cues...
- A plasma membrane-bound putative endo-1,4-beta-D-glucanase is required for normal wall assembly and cell elongation in ArabidopsisF Nicol
Laboratoire de Biologie Cellulaire, Institut National de Recherche Agronomique, Route de Saint Cyr, F 78026 Versailles Cedex, France
EMBO J 17:5563-76. 1998..Although the in vivo substrate remains to be determined, the mutant phenotype is consistent with a central role for KOR in the assembly of the cellulose-hemicellulose network in the expanding cell wall...
- Modular recognition of RNA by a human pumilio-homology domainXiaoqiang Wang
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Cell 110:501-12. 2002..We have mutated these three side chains in one repeat, thereby altering the sequence specificity of Pumilio1. Thus, the high affinity and specificity of the PUM-HD for RNA is achieved using multiple copies of a simple repeated motif...
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteasesVictor Quesada
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Spain
Biochem Biophys Res Commun 314:54-62. 2004....
- ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteinsEdouard De Castro
Swiss Institute of Bioinformatics, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
Nucleic Acids Res 34:W362-5. 2006..Several output modes are available including simple text views and a rich mode providing an interactive match and feature viewer with a graphical representation of results...
- MUSTANG: a multiple structural alignment algorithmArun S Konagurthu
Department of Computer Science and Software Engineering, The University of Melbourne, Parkville, Melbourne, Victoria, 3010 Australia
Proteins 64:559-74. 2006....
- Convergent evolution of domain architectures (is rare)Julian Gough
RIKEN Genomic Sciences Centre, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
Bioinformatics 21:1464-71. 2005..We use a range of methods including phylogenetic grouping, sequence similarity/alignment, mutation rates and comparative genomics to approach this difficult problem from several angles...
- Protein modification by SUMOErica S Johnson
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Annu Rev Biochem 73:355-82. 2004..This review discusses our current understanding of how SUMO conjugation is controlled, as well as the roles of SUMO in a number of biological processes...
- THUMP--a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylasesL Aravind
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Trends Biochem Sci 26:215-7. 2001..We predict that this domain is an RNA-binding domain that adopts an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8...
- STRING: known and predicted protein-protein associations, integrated and transferred across organismsChristian von Mering
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nucleic Acids Res 33:D433-7. 2005..STRING currently holds 730,000 proteins in 180 fully sequenced organisms, and is available at http://string.embl.de/...
- A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transductionJ Li
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Cell 90:929-38. 1997..The extracellular domain contains 25 tandem leucine-rich repeats that resemble repeats found in animal hormone receptors, plant disease resistance genes, and genes involved in unknown signaling pathways controlling plant development...
- Molecular characteristics of insect vitellogenins and vitellogenin receptorsT W Sappington
Department of Entomology, Michigan State University, East Lansing 48824, USA
Insect Biochem Mol Biol 28:277-300. 1998....
- The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9B Conradt
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 93:519-29. 1998..We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex...
- Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeastQ Xu
Burnham Institute Program on Apoptosis and Cell Death Research La Jolla, California 92037, USA
Mol Cell 1:337-46. 1998..Conversely, BI-1 antisense induced apoptosis. BI-1 thus represents a new type of regulator of cell death pathways controlled by Bcl-2 and Bax...
- Matt: local flexibility aids protein multiple structure alignmentMatthew Menke
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS Comput Biol 4:e10. 2008..We postulate that Matt's strong performance comes from its ability to model proteins in different conformational states and, perhaps even more important, its ability to model backbone distortions in more distantly related proteins...
- Evolutionary rate in the protein interaction networkHunter B Fraser
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Science 296:750-2. 2002..We confirm one predicted outcome of this process-namely, that interacting proteins evolve at similar rates...
- A forkhead-domain gene is mutated in a severe speech and language disorderC S Lai
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Nature 413:519-23. 2001..Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language...
- Mutations in the K+ channel signature sequenceL Heginbotham
Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115
Biophys J 66:1061-7. 1994..Furthermore, the results illustrate that the hydroxyl groups at the third and fourth positions, and the aromatic group at position seven, are not essential in determining K+ selectivity...
- A novel superoxide-producing NAD(P)H oxidase in kidneyA Shiose
Department of Molecular and Structural Biology, Kyushu University Graduate School of Medical Science, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Biol Chem 276:1417-23. 2001..The present findings thus suggest that the novel NAD(P)H oxidase NOX4 may serve as an oxygen sensor and/or a regulator of cell growth in kidney...
- Characterization of mammalian selenoproteomesGregory V Kryukov
Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 0664, USA
Science 300:1439-43. 2003..The human selenoproteome consists of 25 selenoproteins...
- Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing proteinF Mueller-Pillasch
Department of Internal Medicine I, University of Ulm, Germany
Oncogene 14:2729-33. 1997..However, the precise role of koc in human tumour cells is unknown and remains to be elucidated...
- An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenitaE Zanaria
Universita di Pavia, Italy
Nature 372:635-41. 1994..DAX-1 encodes a new member of the nuclear hormone receptor superfamily displaying a novel DNA-binding domain. The DAX-1 product acts as a dominant negative regulator of transcription mediated by the retinoic acid receptor...
- Drosophila p53 is a structural and functional homolog of the tumor suppressor p53M Ollmann
Exelixis, Inc, South San Francisco, California 94080, USA
Cell 101:91-101. 2000..These data reveal an ancestral proapoptotic function for p53 and identify Drosophila as an ideal model system for elucidating the p53 apoptotic pathway(s) induced by DNA damage...
- A mechanism for Wnt coreceptor activationKeiko Tamai
Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 13:149-56. 2004..Our study identifies a critical signaling module and a key phosphorylation-dependent activation step of the Wnt receptor complex and reveals a unifying logic for transmembrane signaling by Wnts, growth factors, and cytokines...
- PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerJ Li
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
Science 275:1943-7. 1997..These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions...
- Fifty years of coiled-coils and alpha-helical bundles: a close relationship between sequence and structureDavid A D Parry
Institute of Fundamental Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand
J Struct Biol 163:258-69. 2008..An important development has been the recognition that the delightful simplicity that exists between sequence and structure, and between structure and function, allows coiled coils with specialized features to be designed de novo...
- Colicin biologyEric Cascales
Laboratoire d IngÃ©nierie des SystÃ¨mes MacromolÃ©culaires, Institut de Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, UPR 9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
Microbiol Mol Biol Rev 71:158-229. 2007..The mechanisms of inhibition by specific and cognate immunity proteins are presented. Finally, the use of colicins as laboratory or biotechnological tools and their mode of evolution are discussed...
- Toward a description of the sialome of the adult female mosquito Aedes aegyptiJ G Valenzuela
Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, Bethesda, MD 20892 0425, USA
Insect Biochem Mol Biol 32:1101-22. 2002..The possible role of these proteins in blood and sugar feeding by the mosquito is discussed...
- KH domain: one motif, two foldsN V Grishin
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
Nucleic Acids Res 29:638-43. 2001..Current analysis offers a new look on how proteins can change fold in the course of evolution...
- Identification of human Rap1: implications for telomere evolutionB Li
The Rockefeller University, New York, New York 10021, USA
Cell 101:471-83. 2000..We propose that budding yeast preserved Rap1 at telomeres but lost the TRF component, possibly concomitant with a change in the telomeric repeat sequence...
- Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA exportDivyang Jani
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Mol Cell 33:727-37. 2009..These data indicate Sac3(CID) provides a scaffold within TREX-2 to integrate interactions between protein complexes to facilitate the coupling of transcription and mRNA export during gene expression...
- Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in ArabidopsisS Iuchi
Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
Plant J 27:325-33. 2001..We improved drought tolerance by gene manipulation of AtNCED3 causing the accumulation of endogenous ABA...
- Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletonsC L Leung
Department of Pathology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Biol 147:1275-86. 1999..The properties of MACF are consistent with the observation that mutations in kakapo cause disorganization of microtubules in epidermal muscle attachment cells and some sensory neurons...
- Mapping the D2/D3 Dopamine Receptor Binding SitesROBERT LUEDTKE; Fiscal Year: 2004..neuropsychiatric disorders or drug abuse because the D2 and D3 dopamine receptors have a high degree of amino acid sequence homology within the transmembrane spanning regions, which construct the neutotransmitter binding site...
- Rational Design of Therapeutic Vaccines for CEA+ TumorsSUNIL CHATTERJEE; Fiscal Year: 2007..whether the idio-peptides, (LCD-2 and CEA-B) derived from the structure of 3H1 and CEA based on the amino acid sequence homology, which also induce CD4+Th1 help will be more immunogenic in combination with the agonist CTL peptides ..
- Role of the insulin/IGF-axis in incident CIN-2+Howard D Strickler; Fiscal Year: 2010..that this relationship is due to the prevalence of hyperinsulinemia in obese women, since insulin has amino acid sequence homology, as well as mitogenic/anti-apoptotic activity, in common with IGF-I...
- 3D Structure and Function of CRAC ChannelsSTEPHEN BARSTOW LONG; Fiscal Year: 2013..Aside from being an integral membrane protein, Orai has no significant amino acid sequence homology to other known ions channels...
- Engineered Opioid Receptors as Therapeutic Agents for Pain ControlPing Yee Law; Fiscal Year: 2012..these approaches and others are viable ones, one of the reasons for their limited success is the high amino acid sequence homology among the cloned receptors...
- Function of Longus Type IV pili in enterotoxigenic E coliOSCAR GOMEZ; Fiscal Year: 2010..Information that Longus is immunogenic across variants and that anti-Longus antibodies may block colonization and prevent disease will facilitate the construction of effective ETEC vaccines. ..
- Structural And Biochemical Characterization Of A Novel Mycobacterial Heme UptakeCelia Goulding; Fiscal Year: 2013..With this in mind, the heme uptake pathway provides a number of good protein targets for the development of therapeutics against TB. ..
- Mouse modeling of a human STING gene variant for infectious diseaseJohn C Cambier; Fiscal Year: 2013..It is noteworthy that mouse and human STING proteins share 83% amino acid sequence homology. Thus in the first model (mHAQ mouse), we will make a STING knock-in in which the mouse equivalent ..
- Development and Maintenance of PANTHER SoftwarePaul D Thomas; Fiscal Year: 2010..The results from this methodology will be made broadly available to both researchers and the public, in formats accessible to both people and computers. ..
- MAST CELL MATRIX METALLOPROTEINASES IN LUNG INJURYKenneth Fang; Fiscal Year: 2000..of dog homologues of human MMPs by characterization of substrate specificities and determination of amino acid sequence homology, followed by enzyme purification using sequential chromatographic steps...
- REGULATION OF PILIN EXPRESSIONH Seifert; Fiscal Year: 1993..Gonococcal pilin is a member of a family of pilins that share amino acid sequence homology. The pilin genes from N...
- ESTABLISHMENT OF THE DORSAL-VENTRAL AXIS IN DROSOPHILADavid Stein; Fiscal Year: 2002..is a general mechanism for the regulation of transcription factors and the dorsal gene shares amino acid sequence homology with a number of vertebrate transcription factors whose activities are also regulated in this way...
- OPIOID RECEPTORS ON LYMPHOCYTES AND BRAINJean Bidlack; Fiscal Year: 2007..This chemokine receptor, U51, shares considerable amino acid sequence homology and similarity with the kappa opioid receptor...
- NOVEL METHOD FOR ORGAN TOXICITYCatherine Willett; Fiscal Year: 2002..The toxicity testing and drug screening markets are estimated at $500M and $700M, respectively. ..
- E. COLI HEAT STABLE ENTEROTOXIN AND INTESTINAL RECEPTORLAWRENCE SCHEVING; Fiscal Year: 1993..This peptide has been shown to have core amino acid sequence homology with peptides released by other bacteria and by eukaryotic organisms. Such strains of E...
- MULTIVALENT VACCINE FOR LYMPHATIC FILARIASISRamaswamy Kalyanasundaram; Fiscal Year: 2010..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
- Genetic Analysis of Iron Homeostasis in ZebrafishPaula Fraenkel; Fiscal Year: 2006..These novel genes may become molecular targets for the treatment of iron overload conditions, such as hereditary hemochromatosis. ..
- 11th & 12th Conference on Cancer Therapy with Antibodies and ImmunoconjugatesDavid Goldenberg; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- SEIZURE THRESHOLDS FOR EPILEPSY MUTANTSWAYNE FRANKEL; Fiscal Year: 2001..The identification of mutants with altered neuroexcitability has added value in enriching for other neurobehavioral abnormalities that are difficult to detect in high-throughput screens. ..
- Effect of ethanol on retinoid metabolism and signaling in zebrafish embryosWILLIAM BOSRON; Fiscal Year: 2007..We will assess the feasibility of performing targeted proteomics studies with tissues from other populations that express different SNPs in alcohol metabolizing enzymes. [unreadable] [unreadable] [unreadable]..
- Dynamically Crosslinked HydrogelsRussell Stewart; Fiscal Year: 2006..These novel hydrogels may find wide ranging biomedical applications in drug delivery, as active surface coatings or microactuators in medical devices. ..
- DEVELOPMENTAL EFFECTS OF GROWTH DELAY IN FIDGET MICEWAYNE FRANKEL; Fiscal Year: 2005..Finally, Aim 4 will attempt to gain insight into possible redundancy and action of fidget-related genes by expression studies, modifier gene mapping, and gene targeting. ..
- DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINAJAMES BRENNA; Fiscal Year: 2002..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
- FOLDING OF THE INTRACELLULAR LIPID-BINDING PROTEINSIra Ropson; Fiscal Year: 2003..Single-site mutant proteins will be generated and studied for their effects on the transition state in protein folding. ..
- The Role of surfactant protein genetic variants in cyst*Joanna Floros; Fiscal Year: 2005..aeruginosa and its clearance, and provide the basis for further consideration of novel therapeutic strategies to treat CF-related lung disease. ..
- High-Accuracy Models of Proteins from Remote HomologyJie Liang; Fiscal Year: 2009..These computational capabilities could have profound impacts to drug design and disease studies. ..
- CPT11 activation by carboxylesterases in colon cancerWILLIAM BOSRON; Fiscal Year: 2003..If there is a positive correlation, a future multi-institutional study will be proposed. ..
- OZONE EFFECTS ON FUNCTION OF SURFACTANT PROTEIN VARIANTSJoanna Floros; Fiscal Year: 2010..Knowledge gained may help explain and perhaps link the in vitro data with the human genetic association data, and provide insight in the understanding of the value of the SP-A gene duplication. ..
- Development of RNAi as Treatment for NeurodegenerationKENNETH KOSIK; Fiscal Year: 2005..These experiments open the way for the Colombian scientists to participate directly in the next phase of the research beyond descriptive genetics in which the Colombian group has made such a strong contribution. ..
- GENETIC CONTROL OF NITRATE RESPIRATION IN E. COLIValley J Stewart; Fiscal Year: 2010..Thus, results from the model species E. coli enhance understanding for a broad range of pathogens that significantly impact public health. ..
- Gas phase derivatization for lipidomic MS analysisJAMES BRENNA; Fiscal Year: 2007....
- The biology of gastrin-ferric ion complexesGRAHAM BALDWIN; Fiscal Year: 2009..Recognition that metal ions are essential for the biological activity of NAGs may permit the development of novel therapies for colon cancer. ..
- Energy metabolism and virulence of Bordetella speciesImke Schroeder; Fiscal Year: 2008..The relative contributions of cytochrome oxidase to the infectious cycle will be analyzed in Aim 3 using high-resolution animal models of respiratory tract infection. ..
- Combined Methods for Protein-Structure PredictionKevin Karplus; Fiscal Year: 2007....
- Apoptosis Signaling: BH3 to BH123 ProteinsGOVINDASWAMY CHINNADURAI; Fiscal Year: 2008..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
- Retinoid Metabolism in Hepatitic Stellate CellsWILLIAM BOSRON; Fiscal Year: 2005..Inhibitors of retinyl ester hydrolysis in stellate cells may be an effective therapeutic strategy for arresting stellate cell activation early in hepatic fibrosis. ..
- Attenuating sterol synthesis in WT and NPC mice brainsTa Yuan Chang; Fiscal Year: 2005..Specific Aim 3: To examine the long-term effect of SSI CP-340868 at 2 different doses on life spans of normal and NPC1 mice. ..
- HER 2/Neu--A Target For Cancer ImmunotherapyMALAYA CHATTERJEE; Fiscal Year: 2005..This study will be a prelude to clinical trials for HER2/neu positive cancer patients with a single or combined anti-Id vaccine. ..
- Epidemiology of HIV-1/HIV-2 Dual InfectionGeoffrey Gottlieb; Fiscal Year: 2005....
- ENZYMOLOGY OF ACETOTROPHIC METHANOGENESISJAMES FERRY; Fiscal Year: 2003..The results are expected to contribute not only to a deeper understanding of the acetate fermentation pathway, but more importantly to the broader field of anaerobic microbiology and beyond. ..
- INVESTIGATIONS OF MAMMALIAN AMINOPROPYLTRANSFERASESANTHONY PEGG; Fiscal Year: 2009..abstract_text> ..
- PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERSJAMES BRENNA; Fiscal Year: 2004..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
- ACTIVE SITE DETERMINATION OF THE E-TYPE ATPASESTERENCE KIRLEY; Fiscal Year: 2004..abstract_text> ..
- TISSUE SPECIFIC CONTROL OF CELL PROLIFERATIONWAYNE FRANKEL; Fiscal Year: 2001..In Specific Aim 4, transgenic approaches will be undertaken to functionally analyze the pintail gene and its role in cell type specific control of cell proliferation. ..
- 9/10TH Conf./Cancer Therapy/Antibody/ImmunoconjugatesDavid Goldenberg; Fiscal Year: 2004..The conference chairman, Dr. Goldenberg, has secured two outstanding scientists as co-chairmen, Drs. Ralph Reisfeld (Scripps) and Edward Sausville (NCI). ..
- Biomolecular Analysis of Proteins in Visual DiseaseESTHER BISWAS FISS; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Structure of Microsomal Enzymes in Estrogen BiosynthesisDebashis Ghosh; Fiscal Year: 2005....
- FUNCTIONS AND INTERACTIONS OF PRESENILINSKENNETH KOSIK; Fiscal Year: 2003....
- Self-immobilizing ProteinsRussell Stewart; Fiscal Year: 2005..The widely expected future impact of protein arrays on clinical diagnosis and other areas of human health care may be realized more quickly with new and effective protein modification technology. ..
- Chromaffin Cell physiology: Novel molecular approachesSushil Mahata; Fiscal Year: 2009..These studies, utilizing unique knockout, transgenic, and human variants of catestatin, are likely to establish novel catestatin mechanisms in the development of hypertension and its modulation through nicotinic-cholinergic receptors. ..
- Beta-cell Granule Protein Profile by Split Reporter Ass*Regina Kuliawat; Fiscal Year: 2005..abstract_text> ..
- Development of Cdk5 InhibitorsKENNETH KOSIK; Fiscal Year: 2007..Because compound validation requires a broad expertise that is unlikely to be present in a single lab we have assembled individuals who collectively have the expertise to complete the aims. ..
- LCPUFA Status and Birth Outcome in IndiaJAMES BRENNA; Fiscal Year: 2007..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
- Role of cytochrome oxidases in Bordetella pathogenesisImke Schroeder; Fiscal Year: 2007..Jeffrey F. Miller as co-investigator. Although this study is exploratory in nature Dr. Miller brings extensive expertise on Bordetella genetics and pathogen-animal host interaction to the project. [unreadable] [unreadable]..
- Modulation of Electrogenic Sodium Bicarbonate TransportIra Kurtz; Fiscal Year: 2007..Successful completion of this project will enhance our understanding of the mechanisms responsible for regulating H+/base transporters. ..
- STRUCTURE/FUNCTION AND REACTION MECHANISM OF PGHSAh Lim Tsai; Fiscal Year: 2008..The last aim will provide direct data on the membrane topology of PGHS and the mechanism of its substrate presentation and product release. [unreadable] [unreadable]..
- Magnetic Circular Dichroism/Circular Discroism SystemAh Lim Tsai; Fiscal Year: 2008..To guarantee a reliable MCD/CD facility for ongoing research and training purposes, we chose to buy JASCO spectrometers for their versatile performance, durability and ease of use. [unreadable] [unreadable] [unreadable]..
- GDF Modulation of Tendon Maintenance and RepairBorjana Mikic; Fiscal Year: 2008..These studies combine to enhance our understanding of the mechanisms of action of GDFs in tendon maintenance and repair. ..
- BH3-only protein BNIP3 in tumor progressionGOVINDASWAMY CHINNADURAI; Fiscal Year: 2006..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
- A High-Throughput Assay for Influenza Replicase/RNA Polymerase InhibitorsROBERT KUCHTA; Fiscal Year: 2006..unreadable] [unreadable]..
- Regulation & Function of CalponinJian Ping Jin; Fiscal Year: 2010..The results will provide new insights into many important physiological and pathological processes, such as cell proliferation, cell migration, wound healing, myogenesis, lung alveolar mechanics, and tumor metastasis. ..
- Accelerating metabolic discovery using characterization dataTimothy Lilburn; Fiscal Year: 2007..The fight against well-known pathogens and biothreat agents, as well as against new, emerging pathogens will be greatly aided by these tools. [unreadable] [unreadable] [unreadable] [unreadable]..
- Gut Hormones/Other Circulatory Regulators of AppetiteStephen Bloom; Fiscal Year: 2006..Obesity produces over 6,000 excess deaths a week in the USA alone, yet there is no really effective treatment. This meeting is to advance the most promising approach to a safe practical therapy seen in the last 50 years. ..