Genomes and Genes
Summary: The alignment of CHROMOSOMES at homologous sequences.
Publications243 found, 100 shown here
- Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsisAya Sato
Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA
Cell 139:907-19. 2009..Disruption of microtubules inhibits chromosome pairing, indicating that these connections promote interhomolog interactions...
- The mouse Spo11 gene is required for meiotic chromosome synapsisP J Romanienko
Genetics and Biochemistry Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health 20892, Bethesda, MD, USA
Mol Cell 6:975-87. 2000..We speculate that there is an additional role for Spo11, after it generates DSBs, in synapsis...
- Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanismsLukasz Wojtasz
Institute of Physiological Chemistry, Technische Universitat Dresden, Dresden 01307, Germany
Genes Dev 26:958-73. 2012..Thus, we provide convincing evidence for the existence of a distinct asynapsis surveillance mechanism that safeguards the ploidy of the mammalian germline...
- Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombinationMONICA P COLAIACOVO
Department of Developmental Biology, Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 5:463-74. 2003..Our data also suggest that early prophase barriers to utilization of sister chromatids as repair templates do not depend on central region assembly...
- Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11F Baudat
Cell Biology Program Memorial Sloan Kettering Cancer Center New York, NY 10021, USA
Mol Cell 6:989-98. 2000..Our results also support the view that mammalian checkpoint responses to meiotic recombination and/or synapsis defects are sexually dimorphic...
- Meiotic chromosome pairing is promoted by telomere-led chromosome movements independent of bouquet formationChih Ying Lee
Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
PLoS Genet 8:e1002730. 2012b>Chromosome pairing in meiotic prophase is a prerequisite for the high fidelity of chromosome segregation that haploidizes the genome prior to gamete formation...
- Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegansAmy J MacQueen
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5329, USA
Genes Dev 16:2428-42. 2002....
- Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1Lea Jessop
Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS Genet 2:e155. 2006..These findings show that Sgs1 has potent meiotic anti-CO activity, which is normally antagonized by SIC/ZMM proteins. Our data reinforce previous proposals for an early separation of meiotic processes that form CO and NCO recombinants...
- Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomesYuji Chikashige
Cell Biology Group and CREST Research Project, Kansai Advanced Research Center, National Institute of Information and Communications Technology, 588 2 Iwaoka, Iwaoka cho, Nishi ku, Kobe 651 2492, Japan
Cell 125:59-69. 2006..The bouquet formation plays an important role in homologous chromosome pairing and therefore progression of meiosis...
- The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosisAlexandra Penkner
Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
Dev Cell 12:873-85. 2007..MTF-1/SUN-1 that provides direct evidence for active involvement of the nuclear envelope in homologous chromosome pairing in C. elegans meiosis...
- Silencing of unsynapsed meiotic chromosomes in the mouseJames M A Turner
Division of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nat Genet 37:41-7. 2005..These findings impact on the interpretation of the relationship between synaptic errors and sterility in mammals and extend our understanding of the biology of Brca1...
- HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsisCarolyn M Phillips
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Cell 123:1051-63. 2005..These observations indicate that stabilization of homolog pairing is an active process in which the tethering of chromosome sites to the NE may be necessary but is not sufficient...
- Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegansAmy J MacQueen
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 123:1037-50. 2005..We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability...
- The consequences of asynapsis for mammalian meiosisPaul S Burgoyne
Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
Nat Rev Genet 10:207-16. 2009..Recently it was discovered that the chromatin of asynapsed chromosome segments is transcriptionally silenced, providing new insights into the connection between asynapsis and meiotic impairment...
- Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPaseLukasz Wojtasz
Institute of Physiological Chemistry, Technische Universitat Dresden, Dresden, Germany
PLoS Genet 5:e1000702. 2009..Taken together, our observations raise the possibility that involvement of meiotic HORMA-domain proteins in the regulation of homologue interactions is conserved in mammals...
- Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1Alexandra M Penkner
Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, 1030 Vienna, Austria
Cell 139:920-33. 2009....
- Asy1, a protein required for meiotic chromosome synapsis, localizes to axis-associated chromatin in Arabidopsis and BrassicaSusan J Armstrong
School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK
J Cell Sci 115:3645-55. 2002....
- HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosisEnrique Martinez-Perez
Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA
Genes Dev 19:2727-43. 2005..We propose a model in which HTP-1 functions to establish or maintain multiple constraints that operate to ensure coordination of events leading to chiasma formation...
- SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytesMarina A Bellani
Genetics and Biochemistry Branch, NIDDK, NIH, Bethesda, MD 20892, USA
J Cell Sci 118:3233-45. 2005....
- Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosisMiki Shinohara
Institute for Protein Research, Osaka University, Suita 565 0871, Japan
Nat Genet 40:299-309. 2008..In contrast, crossover assurance requires all ZMM proteins and full-length synaptonemal complexes...
- ZMM proteins during meiosis: crossover artists at workAudrey Lynn
Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA
Chromosome Res 15:591-605. 2007..This review focuses on recent insights into ZMM functions in yeast meiosis and draws comparisons to ZMM-related proteins in other model organisms...
- Early decision; meiotic crossover interference prior to stable strand exchange and synapsisDouglas K Bishop
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
Cell 117:9-15. 2004..Chromosome synapsis occurs after CO/NCO designation and is not required for the regulated distribution of COs along chromosomes manifested as CO interference...
- Homologous pairing and the role of pairing centers in meiosisJui He Tsai
Department of Biochemistry, Cellular, and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA
J Cell Sci 124:1955-63. 2011..In C. elegans, each chromosome contains a single PC that stabilizes chromosome pairing and initiates synapsis of homologous chromosomes...
- Pathways to meiotic recombination in Arabidopsis thalianaKim Osman
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
New Phytol 190:523-44. 2011..We also assess the relationship between meiotic recombination in Arabidopsis and other eukaryotes, highlighting areas of close similarity and apparent differences...
- A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombinationJill E Falk
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Dev Cell 19:599-611. 2010....
- HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosisWilliam Goodyer
Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
Dev Cell 14:263-74. 2008..b>Chromosome pairing and synapsis proceed independently of recombination in worms and flies, suggesting a paradoxical lack of ..
- Homologous pairing and chromosome dynamics in meiosis and mitosisBruce D McKee
Department of Biochemistry and Cellular and Molecular Biology and Genome Sciences and Technology Program, University of Tennessee, Knoxville, M407 Walters Life Sciences Building, Knoxville, TN 37996 0840, USA
Biochim Biophys Acta 1677:165-80. 2004..I cite evidence that may point to a relationship between matrix attachment sites and homologous pairing sites...
- Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegansNicola C Harper
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3220, USA
Dev Cell 21:934-47. 2011..We demonstrate that PCs recruit the Polo-like kinase PLK-2 to induce NE remodeling, chromosome pairing, and synapsis...
- Distribution of meiotic recombination events: talking to your neighborsEnrique Martinez-Perez
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK
Curr Opin Genet Dev 19:105-12. 2009..Here, we review the different levels of apparent control of meiotic crossover formation and distribution...
- Chromosome choreography: the meiotic balletScott L Page
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
Science 301:785-9. 2003..Failures to properly accomplish this elegant chromosome dance result in aneuploidy, a major cause of miscarriage and birth defects in human beings...
- A synaptonemal complex protein promotes homology-independent centromere couplingTomomi Tsubouchi
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Science 308:870-3. 2005..Regions of synaptonemal complex assembled early in meiosis are often centromere-associated. We propose that centromere coupling facilitates homolog pairing and promotes synapsis initiation...
- Recombination proteins mediate meiotic spatial chromosome organization and pairingAurora Storlazzi
Institut de Genetique et Microbiologie, UMR 8621, Universite Paris Sud, 91405 Orsay, France
Cell 141:94-106. 2010Meiotic chromosome pairing involves not only recognition of homology but also juxtaposition of entire chromosomes in a topologically regular way...
- A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegansCarolyn M Phillips
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Dev Cell 11:817-29. 2006Homologous chromosome pairing and synapsis are prerequisite for accurate chromosome segregation during meiosis. Here, we show that a family of four related C2H2 zinc-finger proteins plays a central role in these events in C. elegans...
- Evidence that meiotic sex chromosome inactivation is essential for male fertilityHelene Royo
Department of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Curr Biol 20:2117-23. 2010..Our findings show that MSCI is essential for male meiosis and, as such, provide insight into the differential severity of meiotic mutations' effects on male and female meiosis...
- Initiation of meiotic chromosome synapsis at centromeres in budding yeastTomomi Tsubouchi
Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
Genes Dev 22:3217-26. 2008..Our data provide evidence for two classes of synapsis initiation events that differ in location, timing, genetic requirements, and relationship to meiotic recombination...
- Checkpoint mechanisms: the puppet masters of meiotic prophaseAmy J MacQueen
Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, CT 06459, USA
Trends Cell Biol 21:393-400. 2011....
- The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and countingMary E Donohoe
Howard Hughes Medical Institute, USA
Nature 460:128-32. 2009..Somatic XCI is regulated by homologous X-chromosome pairing and counting, and by the random choice of future active and inactive X chromosomes...
- C. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progressionMichiko Hayashi
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Genet 3:e191. 2007..Our data further suggest that meiotic cohesin component REC-8 may play a role in limiting the activity of SPO-11 in generating meiotic DSBs and that RAD-50 may function in counteracting this inhibition...
- Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombinationMichael N Conrad
Program in Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Cell 133:1175-87. 2008..Together with recombination defects described for ndj1, our observations suggest that RPMs and SCs balance the disruption and stabilization of recombinational interactions, respectively, to regulate crossing over...
- Meiosis: making a break for itJudith Yanowitz
Magee Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
Curr Opin Cell Biol 22:744-51. 2010..Hum Mol Genet 2007, 16 Spec No. 2:R203-R208.). This review will focus on recent advances in our understanding of key meiotic events and how coordination of these events is occurring...
- A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegansNeedhi Bhalla
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Science 310:1683-6. 2005..Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved...
- Positional cloning and characterization of mouse mei8, a disrupted allelle of the meiotic cohesin Rec8Laura A Bannister
The Jackson Laboratory, Bar Harbor, Maine, USA
Genesis 40:184-94. 2004..However, unlike yeast and Caenorhabditis elegans, localization of REC8 on meiotic chromosomes is not required for the assembly of axial elements...
- Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombinationEkaterina Revenkova
Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Nat Cell Biol 6:555-62. 2004..Thus, SMC1 beta has a key role in meiotic cohesion, the assembly of AEs, synapsis, recombination, and chromosome movements...
- A pathway for synapsis initiation during zygotene in Drosophila oocytesNikhila S Tanneti
Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Curr Biol 21:1852-7. 2011..Furthermore, the early euchromatic SC initiation events at mid-zygotene may be required for DSBs to be repaired as crossovers...
- Pch2 acts through Xrs2 and Tel1/ATM to modulate interhomolog bias and checkpoint function during meiosisHsuan Chung Ho
Department of Molecular and Cellular Biology, University of California Davis, Davis, California, USA
PLoS Genet 7:e1002351. 2011..In addition, Xrs2, like Pch2, is required for checkpoint-mediated delay conferred by the failure to synapse chromosomes...
- A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairingKei Ichiro Ishiguro
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
EMBO Rep 12:267-75. 2011..Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway...
- Mapping PrBn and other quantitative trait loci responsible for the control of homeologous chromosome pairing in oilseed rape (Brassica napus L.) haploidsZhiqian Liu
UMR INRA Agrocampus Rennes, Amelioration des Plantes et Biotechnologies Vegetales, Le Rheu, France
Genetics 174:1583-96. 2006In allopolyploid species, fair meiosis could be challenged by homeologous chromosome pairing and is usually achieved by the action of homeologous pairing suppressor genes...
- The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repairHideo Tsubouchi
Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
Mol Cell Biol 22:3078-88. 2002..These results suggest that Hop2 and Mnd1 work as a complex to promote meiotic chromosome pairing and DSB repair...
- Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosisHuiling Xu
Divisions of Radiation Oncology and Research, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia
Dev Cell 8:949-61. 2005..In the absence of REC8, early chromosome pairing events appear normal, but synapsis occurs in a novel fashion: between sister chromatids...
- Polo kinases establish links between meiotic chromosomes and cytoskeletal forces essential for homolog pairingSara Labella
Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, Quebec H2A 1B1, Canada
Dev Cell 21:948-58. 2011..Loss of plk-2 inhibits chromosome pairing and licenses synapsis between nonhomologous chromosomes, indicating that PLK-2 is required for PC-mediated ..
- Homologous pairing preceding SPO11-mediated double-strand breaks in miceKingsley A Boateng
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 24:196-205. 2013..Strikingly, this early chromosome pairing still requires SPO11 but is not dependent on its ability to make DSBs or homologous recombination proteins...
- The role of specialized transcription factories in chromosome pairingMeng Xu
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE UK
Biochim Biophys Acta 1783:2155-60. 2008..Then, interactions between promoters and RNA polymerases in the factories mediate pairing...
- Nucleolus-associated telomere clustering and pairing precede meiotic chromosome synapsis in Arabidopsis thalianaS J Armstrong
School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK
J Cell Sci 114:4207-17. 2001..We propose that in Arabidopsis the classical leptotene/zygotene bouquet is absent and is replaced functionally by nucleolus-associated telomere clustering...
- Transvection in DrosophilaJames A Kennison
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Adv Genet 46:399-420. 2002..molecular mechanisms probably underlie the changes in gene expression that are observed after disrupting chromosome pairing. Transvection in the bithorax-complex appears to result from the ability of cis-regulatory elements to ..
- Prelude to a divisionNeedhi Bhalla
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA
Annu Rev Cell Dev Biol 24:397-424. 2008..These links are usually established through chromosome pairing, synapsis, and recombination, which occur during meiotic prophase...
- Distinct properties of the XY pseudoautosomal region crucial for male meiosisLiisa Kauppi
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Science 331:916-20. 2011..Our findings uncover specific mechanisms that surmount the unique challenges of X-Y recombination...
- DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosisAkiko Inagaki
Department of Reproduction and Development, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Epigenetics 5:255-66. 2010b>Chromosome pairing and synapsis during meiotic prophase requires the formation and repair of DNA double-strand breaks (DSBs) by the topoisomerase-like enzyme SPO11...
- The multiple roles of cohesin in meiotic chromosome morphogenesis and pairingGloria A Brar
David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Mol Biol Cell 20:1030-47. 2009..These findings define Rec8 as a key determinant of meiotic chromosome morphogenesis and a central player in multiple meiotic events...
- Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivationShantha K Mahadevaiah
Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
J Cell Biol 182:263-76. 2008..Apoptosis does not occur in mice with a single additional asynapsed chromosome with unrepaired meiotic DSBs and no disturbance of MSCI...
- Synaptonemal complex-dependent centromeric clustering and the initiation of synapsis in Drosophila oocytesSatomi Takeo
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Curr Biol 21:1845-51. 2011..Our data support a view in which the SC-mediated clustering at the centromeres is the initiating event for meiotic synapsis...
- HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegansFlorence Couteau
Department of Biology, McGill University, Montreal, Canada
Genes Dev 19:2744-56. 2005..Furthermore, our results suggest that early steps of recombination occur in a narrow window of opportunity in early prophase that ends with SC assembly, resulting in a mechanistic coupling of the two processes to promote crossing over...
- Meiosis-specific noncoding RNA mediates robust pairing of homologous chromosomes in meiosisDa Qiao Ding
Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Kobe 651 2492, Japan
Science 336:732-6. 2012..Thus, we propose that RNA transcripts retained on the chromosome play an active role in recognition of homologous chromosomes for pairing...
- Disruption of topoisomerase II perturbs pairing in drosophila cell cultureBenjamin R Williams
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genetics 177:31-46. 2007..Finally, our data indicate that disrupting Drosophila topoisomerase II (Top2) gene function with RNAi and chemical inhibitors perturbs homolog pairing, suggesting Top2 to be a gene important for pairing...
- The Sgs1 helicase regulates chromosome synapsis and meiotic crossing overBeth Rockmill
Howard Hughes Medical Institute, Yale University, P O Box 208103, New Haven, 06520 CT, USA
Curr Biol 13:1954-62. 2003..Like the human Bloom syndrome helicase (BLM), Sgs1 functions during both vegetative growth and meiosis. The sgs1 null mutant sporulates poorly and displays reduced spore viability...
- The importance of genetic recombination for fidelity of chromosome pairing in meiosisHideo Tsubouchi
Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Dev Cell 5:915-25. 2003..the hop2 mutant phenotype demonstrates the importance of the recombination machinery in promoting accurate chromosome pairing. We propose that the Dmc1/Rad51 recombinases require Hop2 to distinguish homologous from nonhomologous ..
- SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegansSarit Smolikov
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Genetics 176:2015-25. 2007..Altogether, our studies lead us to propose that SYP-3 regulates synapsis along chromosomes, contributing to meiotic progression in early prophase...
- Fpr3 and Zip3 ensure that initiation of meiotic recombination precedes chromosome synapsis in budding yeastAmy J MacQueen
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Curr Biol 19:1519-26. 2009..A distinguishing feature of meiosis in budding yeast and mammals is that synapsis between homologs depends upon recombination; however, the molecular basis for this contingency is not understood...
- A bouquet of chromosomesLisa Harper
Department of Molecular and Cell Biology, University of California Berkeley, 345 LSA 3200, Berkeley, CA 94720 3200, USA
J Cell Sci 117:4025-32. 2004..and initiation of chromosome synapsis has led to the hypothesis that the bouquet facilitates homologous chromosome pairing and synapsis...
- Retinoblastoma protein is essential for early meiotic events in ArabidopsisZhong Chen
Temasek Life Sciences Laboratory, Singapore
EMBO J 30:744-55. 2011..Our results indicate that RBR has an important role in meiosis affecting different aspects of this complex process...
- Sustained and rapid chromosome movements are critical for chromosome pairing and meiotic progression in budding yeastMegan Sonntag Brown
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
Genetics 188:21-32. 2011..csm4-3 mutants show a general defect in chromosome motion but an intermediate defect in chromosome pairing. Chromosome velocity analysis in live cells showed that while average chromosome velocity was strongly ..
- The molecular control of meiotic chromosomal behavior: events in early meiotic prophase in Drosophila oocytesCathleen M Lake
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Annu Rev Physiol 74:425-51. 2012..Finally, we correlate what is known in Drosophila oocytes with our understanding of these processes in other systems...
- The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male miceNadège Vernet
Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Curr Biol 21:787-93. 2011..These findings provide further insight into the basis for the much lower transmission of chromosomal errors originating at the first meiotic division in men than in women ...
- Interlock formation and coiling of meiotic chromosome axes during synapsisChung Ju Rachel Wang
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Genetics 183:905-15. 2009..Since interlocks are potentially deleterious if left unresolved, possible mechanisms for their resolution are discussed in this article...
- Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screenEric F Joyce
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 8:e1002667. 2012..In combination with a variety of secondary assays, these results provide insights into the mechanism and dynamics of somatic pairing...
- The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filamentsXavier Veaute
CEA, DSV, Departement de Radiobiologie et Radiopathologie, UMR217 CNRS CEA, BP6, 92265 Fontenay aux Roses Cedex, France
Nature 423:309-12. 2003..These data provide an explanation for the anti-recombinogenic role of Srs2 in vivo and highlight a previously unknown mechanism for recombination control...
- Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiationOsamu Masui
Institut Curie, Paris, France
Cell 145:447-58. 2011....
- Pairing-sensitive silencing, polycomb group response elements, and transposon homing in DrosophilaJudith A Kassis
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Adv Genet 46:421-38. 2002..I suggest that DNA fragments that cause transposon homing or pairing-sensitive silencing are bound by protein complexes that can interact to bring together distant DNA fragments...
- Changing partners: moving from non-homologous to homologous centromere pairing in meiosisMara N Stewart
Molecular, Cellular and Developmental Biology, 347 UCB, Colorado Avenue, University of Colorado, Boulder, CO 80309 0347, USA
Trends Genet 24:564-73. 2008..Moreover, such pairing could have previously unrecognized roles in mediating chromosome organization or architecture that impact meiotic segregation fidelity...
- PAIR2 is essential for homologous chromosome synapsis in rice meiosis IKen ichi Nonomura
Experimental Farm Plant Genetics Laboratory, National Institute of Genetics, Yata1111, Mishima, Shizuoka 411 8540, Japan
J Cell Sci 119:217-25. 2006..However, PAIR2 does not play a role in AE formation, sister chromatid cohesion at centromeres or kinetochore assembly in meiosis I of rice...
- STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensationManuel Mark
Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U596, CNRS UMR7104, Illkirch, France
J Cell Sci 121:3233-42. 2008..a prolonged bouquet-stage configuration, asynapsis and heterosynapsis, suggesting function(s) of STRA8 in chromosome pairing. Most importantly, a large number of mutant leptotene spermatocytes underwent premature chromosome ..
- Meiotic pairing and segregation of achiasmate sex chromosomes in eutherian mammals: the role of SYCP3 proteinRoberto de la Fuente
Unidad de Biologia Celular, Departamento de Biologia, Universidad Autonoma de Madrid, Madrid, Spain
PLoS Genet 3:e198. 2007..These results demonstrate that some components of the SC may participate in the segregation of achiasmate sex chromosomes in eutherian mammals...
- Effective chromosome pairing requires chromatin remodeling at the onset of meiosisIsabelle Colas
John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, United Kingdom
Proc Natl Acad Sci U S A 105:6075-80. 2008..Moreover, a failure to undergo remodeling results in reduced pairing between the homologues. Thus, chromatin remodeling at the onset of meiosis enables the chromosomes to become competent to pair and recombine efficiently...
- Close, stable homolog juxtaposition during meiosis in budding yeast is dependent on meiotic recombination, occurs independently of synapsis, and is distinct from DSB-independent pairing contactsTamara L Peoples
Section of Molecular and Cellular Biology, University of California, Davis, Davis, California 95616, USA
Genes Dev 16:1682-95. 2002..These data suggest that stable, close homolog juxtaposition in yeast is distinct from pre-DSB pairing interactions, requires both DSB and SEI formation, but does not depend on crossovers or SC...
- A genomewide survey argues that every zygotic gene product is dispensable for the initiation of somatic homolog pairing in DrosophilaJack R Bateman
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genetics 180:1329-42. 2008..From these data, we conclude that the initiation of pairing can occur independently of zygotic control and may therefore be part of the developmental program encoded by the maternal genome...
- Effect of colchicine and telocentric chromosome conformation on centromere and telomere dynamics at meiotic prophase I in wheat-rye additionsEduardo Corredor
Departamento de Genetica, Facultad de Biologia, Universidad Complutense, 28040, Madrid, Spain
Chromosome Res 15:231-45. 2007..We have analysed the role of these structures in meiotic chromosome pairing in wheat-rye addition lines by applying colchicine for disturbing presynaptic telomere movements and by ..
- From early homologue recognition to synaptonemal complex formationDenise Zickler
Universite Paris Sud, Institut de Genetique et Microbiologie, 91405, Orsay, France
Chromosoma 115:158-74. 2006....
- Mps3 SUN domain is important for chromosome motion and juxtaposition of homologous chromosomes during meiosisHanumanthu B D Prasada Rao
Institute for Protein Research, Graduate School of Science, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Genes Cells 16:1081-96. 2011..These findings suggest that in meiosis, the Mps3 SUN domain is important for modulating chromosome motion events that act in meiotic chromosome juxtaposition and by extension, promoting proper morphogenesis of the synaptonemal complex...
- Molecular assembly of meiotic proteins Asy1 and Zyp1 and pairing promiscuity in rye (Secale cereale L.) and its synaptic mutant sy10E I Mikhailova
Department of Genetics, Saint Petersburg State University, Russian Academy of Sciences, Russia
Genetics 174:1247-58. 2006..Inferences about the nature of synapsis in this mutant were drawn from such observations...
- MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist TetrahymenaAgnieszka Lukaszewicz
Department of Chromosome Biology and Max F Perutz Laboratories, Center for Molecular Biology, University of Vienna, Dr Bohr Gasse 1, Vienna, Austria
Chromosoma 119:505-18. 2010..X in mre11∆ mutant. However, mre11∆ and com1∆ mutants are unable to repair DSBs, and chromosome pairing is reduced...
- Abnormal synapses and recombination in an azoospermic male carrier of a reciprocal translocation t(1;21)Mei Leng
Laboratory of Molecular and Cell Genetics, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Anhui, People s Republic of China
Fertil Steril 91:1293.e17-22. 2009..To study the meiotic abnormalities during prophase I in an azoospermic man with t(1;21) reciprocal translocation...
- Mutations in Caenorhabditis elegans him-19 show meiotic defects that worsen with ageLois Tang
Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
Mol Biol Cell 21:885-96. 2010..This finding is consistent with depletion of a him-19-dependent factor during the production of oocytes. Further characterization of him-19 could contribute to our understanding of age-dependent meiotic defects in humans...
- Evolutionary consequences of autopolyploidyChristian Parisod
National Centre for Biosystematics, University of Oslo, 0318 Oslo, Norway
New Phytol 186:5-17. 2010..In addition, autopolyploids should possess increased genome flexibility, allowing them to adapt and persist across heterogeneous landscapes in the long run...
- Molecular characterization of Ph1 as a major chromosome pairing locus in polyploid wheatSimon Griffiths
John Innes Centre, Colney, Norwich NR4 7UH, UK
Nature 439:749-52. 2006..The correlation of the presence of this structure with Ph1 activity in related species, and the involvement of heterochromatin with Ph1 (ref. 6) and cdc2 genes with meiosis, makes the structure a good candidate for the Ph1 locus...
- OsSPO11-1 is essential for both homologous chromosome pairing and crossover formation in riceHengxiu Yu
Key Laboratory of Crop Genetics and Physiology of Jiangsu Province Key Laboratory of Plant Functional Genomics of Ministry of Education, Yangzhou University, Yangzhou, 225009, China
Chromosoma 119:625-36. 2010..loss-of-function of OsSPO11-1 have no apparent growth defects during vegetative development, but homologous chromosome pairing and recombination are significantly obstructed...
- Chromosome pairing affinities in interspecific hybrids reflect phylogenetic distances among lady's slipper orchids (Paphiopedilum)Yung I Lee
Botany Department, National Museum of Natural Science, Taichung, Taiwan
Ann Bot 108:113-21. 2011..used for breeding improved cultivars; however, information regarding the genome affinities of species and chromosome pairing behaviour of the hybrids remains almost unknown...
- Homologous chromosome pairing in Schizosaccharomyces pombeJennifer L Wells
North West Cancer Research Fund Institute, University of Wales Bangor, Memorial Building, Bangor, Gwynedd, L57 2UW, UK
Yeast 23:977-89. 2006Homologous chromosome pairing is a central feature of meiosis I, contributing to the correct segregation of chromosomes during meiosis...
- Sister chromosome pairing maintains heterozygosity in parthenogenetic lizardsAracely A Lutes
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Nature 464:283-6. 2010..Sister chromosome pairing provides a mechanism for the maintenance of heterozygosity, which is critical for offsetting the reduced ..
- PHS1 regulates meiotic recombination and homologous chromosome pairing by controlling the transport of RAD50 to the nucleusArnaud Ronceret
Department of Plant Breeding and Genetics, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 106:20121-6. 2009..The POOR HOMOLOGOUS SYNAPSIS1 (PHS1) gene acts in coordination of chromosome pairing and early recombination steps in plants, ensuring pairing fidelity and proper repair of meiotic DNA double-..
- Roles of Hop1 and Mek1 in meiotic chromosome pairing and recombination partner choice in Schizosaccharomyces pombeVitaly Latypov
Institute of Cell Biology, University of Berne, Baltzer Strasse 4, CH 3012 Berne, Switzerland
Mol Cell Biol 30:1570-81. 2010....
- Chromosome dynamics in meiotic prophase I in plantsA Ronceret
Institut Jean Pierre Bourgin, INRA de Versailles, Station de Génétique et d Amélioration des Plantes UR 254, Versailles, France
Cytogenet Genome Res 129:173-83. 2010..The bouquet has been traditionally thought to facilitate chromosome pairing by bringing chromosome ends into close proximity, but recent studies suggest that its main role may rather ..
- A- and B-chromosome pairing and recombination in male meiosis of the silver fox (Vulpes vulpes L., 1758, Carnivora, Canidae)Ekaterina A Basheva
Institute of Cytology and Genetics, Siberian Department, Russian Academy of Sciences, Novosibirsk, 630090, Russia
Chromosome Res 18:689-96. 2010We examined A- and B-chromosome pairing and recombination in 12 males from the farm-bred population of the silver fox (2n = 34 + 0-10 Bs) by means of electron and immunofluorescent microscopy...
- Meiosis, SUMOylation and the ZIP3 Protein: Parallel Studies in Mouse and Yeast.Neil Hunter; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: Chromosome pairing and homologous recombination are required for sexual reproduction and chromosome repair...
- Epigenetic control of sex chromosome behavior in meiosis.JoAnne Engebrecht; Fiscal Year: 2013..During meiosis, chromosome pairing, synapsis and crossing over rely on homology between the paternal and maternal homologous chromosomes to ..
- 2012 Meiosis Gordon Research Conference and Gordon Research SeminarNancy M Hollingsworth; Fiscal Year: 2012..meiotic progression, cell cycle checkpoints, histone modifications and control of meiotic gene expression, chromosome pairing and synapsis, sister chromatid cohesion, the meiotic bouquet and the nuclear envelope, chromosome ..
- Regulation of chromosome synapsis in micePeijing Jeremy Wang; Fiscal Year: 2013..Completion of this project will provide insight into the etiology of male infertility and birth defects in humans. ..
- Chromosome pairing and condensinsGiovanni Bosco; Fiscal Year: 2012..to mediate recombination independent meiotic pairing, there is nothing known about what regulates somatic chromosome pairing. It is not known whether somatic and meiotic chromosome pairing are structurally similar or if they are ..
- Functions of TEX11 and its associated proteins in mice and humansPeijing Jeremy Wang; Fiscal Year: 2013..Together, our studies will elucidate the TEX11-dependent mechanisms underlying the regulation of meiosis in both mice and humans, and provide insight into the molecular etiology of X-linked male infertility in humans. ..
- Single Molecule Studies of Recombination and Chromosome Pairing in MeiosisRichard Fishel; Fiscal Year: 2013..The reassortment of genetic information that is the basis of modern genetics. Mistakes in meiosis chromosome pairing and segregation are the frequent cause of spontaneous miscarriages as well as genetic diseases such as Down ..
- PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILAKENT GOLIC; Fiscal Year: 2002..Historically, most interest in chromosome pairing has focused on the first meiotic division, where pairing is essential for recombination and proper ..
- Regulation of Synaptonemal Complex Assembly During Meiosis in S. cerevisiaeAMY JOY MACQUEEN; Fiscal Year: 2011..Despite over a century of observing meiotic chromosome pairing and synapsis in diverse organisms, the molecular mechanisms underlying fundamental meiotic chromosomal ..
- FUNCTION OF THE SUBUNITS OF EUKARYOTIC CHROMOSOMESWILLIAM GARRARD; Fiscal Year: 2013..heterochromatin localization, Igk allele contraction and looping, and heterologous and homologous Ig allele chromosome pairing.) 2...
- Regulation of X-Chromosome Inactivation and Imprinting by Non-coding ElementsJeannie T Lee; Fiscal Year: 2013..Specifically, we will: (i) Investigate whether and how RNAs play a role in homologous X-chromosome pairing, a process proposed to regulate counting and choosing of X-chromosomes for inactivation;(ii) Determine how ..
- MEIOTIC CHROMOSOME SYNAPSIS AND RECOMBINATION IN YEASTNANCY E KLECKNER; Fiscal Year: 2013..homologous chromosomes communicate with one another, via recombination and recombination-mediated whole chromosome pairing during meiosis...
- Homologous chromosome pairing during meiosis in yeastSean M Burgess; Fiscal Year: 2013..The results of these studies will lead to an understanding of the relationship between the structural features of chromosomes during meiosis and the forces that act upon them. ..
- CHROMOSOME STRUCTURES AND MEIOTIC MECHANISMSMARJORIE MAGUIRE; Fiscal Year: 1990..from several avenues of approach, the nature of cellular structures and processes involved in homologous chromosome pairing, genetic recombination, crossover interference, the maintenance of chiasmate association, and chromosome ..
- CHROMOSOME PAIRING AND NONDISJUNCTION IN HUMAN MEIOSISEdith Cheng; Fiscal Year: 2000..Multicolor FISH will be used to evaluate for heterologous associations in early meiosis to determine their significance in the formation of structural rearrangements. ..
- ROLE OF G4-DNA IN THE PAIRING OF CHROMOSOMESWalter Gilbert; Fiscal Year: 1991..The significance of the G4-DNA hypothesis is that it provides an understanding of how chromosome pairing is accomplished throughout eukaryotic organisms and explains why four chromatids are involved in ..
- Meiotic telemere clustering in fission yeastW Cande; Fiscal Year: 2006The close relationship between the timing of telomere clustering and initiation of chromosome pairing during meiotic prophase has led to the suggestion that the bouquet like arrangement of telomeres on the Nuclear Envelope (NE) is a key ..
- CRYPTIC TELOMERE ABNORMALITIES IN MENTAL RETARDATIONDavid Ledbetter; Fiscal Year: 2002..Aspects of telomere structure and polymorphism may mediate nonhomologous chromosome pairing and unequal cross-over events leading to gene dosage imbalance...
- Regulation of Synaptonemal Complex Assembly During Meiosis in S. cerevisiaeAMY MACQUEEN; Fiscal Year: 2009..Despite over a century of observing meiotic chromosome pairing and synapsis in diverse organisms, the molecular mechanisms underlying fundamental meiotic chromosomal ..
- CYTOGENETIC AND MOLECULAR STUDIES OF HUMAN TRISOMYTerry Hassold; Fiscal Year: 1990..Furthermore, it is not known if the errors leading to trisomy involve faulty chromosome pairing and/or separation or even whether the primary event involves the chromosome itself, the spindle or another ..
- STIMULATION OF CHROMOSOME PAIRING AND EXCHANGE BY RDNABRUCE MCKEE; Fiscal Year: 1992..Student assistants are provided. The RCDA would provide badly needed release time from the rather heavy teaching load at UW-Eau Claire, permitting a period of full time commitment to the research goals outlined above...
- GORDON RESEARCH CONFERENCE ON MEIOSISNancy Kleckner; Fiscal Year: 1992..In addition to the scheduled talks, there will be a workshop on the cytogenetic analysis of chromosome pairing and two poster sessions...
- Leica TCS SP2 AOBS Vis-UV Confocal MicroscopeMargaret Fuller; Fiscal Year: 2003..of cytoskeletal function and membrane trafficking during cell division (Fuller), and vi) mechanisms of chromosome pairing and synapsis during meiosis (Villeneuve)...
- Genetic and Molecular Study of Meiotic Trans-sensing and Meiotic SilencingRodolfo Aramayo; Fiscal Year: 2009..b>Chromosome pairing is an important and conserved mechanical event...
- POSITION DEPENDENT GENE EXPRESSION IN DROSOPHILAVincenzo Pirrotta; Fiscal Year: 1992Genetic effects such as transvection (the interallelic complementation that is dependent on chromosome pairing) and the zeste-white effect, show that interactions occur between chromosome regions separated by many tens of kb or located on ..
- GENETIC CONTROL OF THE MEIOTIC PROCESSRICHARD GETHMANN; Fiscal Year: 1980..and (2) the identification and localization of those regions of the chromosome that are important in chromosome pairing and disjunction...
- Minority Predoctorial Fellowship ProgramNICK HERRERA; Fiscal Year: 2004..Fission yeast cells lacking rec12+ are deficient for recombination, which is required for normal chromosome pairing and segregation during the meiotic divisions...
- DEVELOPMENT OF Q-DOTS AS BIOLOGICAL PROBESShimon Weiss; Fiscal Year: 2001..map large number of distinct markers on chromosomes and combed DNA molecules and monitor the kinetics of chromosome pairing during meiotic prophase...
- Mechanism of Meiotic Pairing in DrosophilaBRUCE MCKEE; Fiscal Year: 2007..3) What is the molecular basis for homologous pairing in early prophase. 4) How are homologous pairing and conjunction related? We will use predominant genetic and cell biological methods to address these questions. ..
- Characterization of V(D)J cleavage and repair complexesPATRICK SWANSON; Fiscal Year: 2007..abstract_text> ..
- Meiotic spindle formation in Drosophila femalesKim S McKim; Fiscal Year: 2010..The objective of these studies is to understand how these errors occur. ..
- Genome-wide analysis of genetic variation and expression.Vivian G Cheung; Fiscal Year: 2010..Therefore, the molecular and analytical approaches developed here can be generalized and applied to the study of other quantitative traits in humans, including complex genetic diseases. ..
- BIOREGULATION OF THE SPERMATOGONIAL STEM CELL LINEAGELAURA TRES; Fiscal Year: 2003..2. In the long range, the discovery of ways to prevent and modulate spermatogonial cell death may have significant therapeutic and anticonceptive potentials in humans. ..
- Neurobiology of high alcohol-seeking behaviorWILLIAM JOSEPH MCBRIDE; Fiscal Year: 2010....
- Genetic Silencing in Germline Maintenance and FunctionWilliam G Kelly; Fiscal Year: 2010..Epigenetic mechanisms operating in the germ line are essential for the establishment of imprinting and the prevention of heritable genetic mutations, both of which are crucial for normal human health and normal human development. ..
- Emerging Mechanisms of Epigenetic RegulationJEANNIE LEE; Fiscal Year: 2003..Appreciate the agricultural implications of epigenetics, such as those relating to plant viral defense mechanisms, animal cloning, and imprinting. ..
- Metotic Spindle Assembly and Aneuploidy in MammalsDuane Compton; Fiscal Year: 2003..abstract_text> ..
- Involvement of Aldehydes in Alcohol AddictionWilliam McBride; Fiscal Year: 2002..Such results could provide valuable information on novel mechanisms underlying the addictive properties of alcohol and would provide a firm scientific foundation for future neurobiological studies. ..
- CHARACTERIZATION OF MAPPED HUMAN BAC CLONESVivian Cheung; Fiscal Year: 2002..In the process of characterizing the clones, we will also get information that gives us insight into the concordance rate between RH map, genome sequence map and cytogenetic map. ..
- Gene Expression Phenotype in Autosomal Recessive DiseaseVivian Cheung; Fiscal Year: 2007..The approach can also be broadened to study the contribution of heterozygosity of recessive diseases to the complex genetic architecture of human diseases and traits. [unreadable] [unreadable]..
- THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSALEdgar Garcia Rill; Fiscal Year: 2002..However, the optimal stimulation sites and paradigms muse be identified and proven effective, first, in control populations, and later, in pathological populations. ..
- JEOL JEM-1010 transmission electron microscope & CameraDuane Compton; Fiscal Year: 2002..The research of the principle investigators cannot be completed without continued availability of a transmission electron microscope. ..
- IBD MAPPING & PATTERN OF HUMAN MEIOTIC RECOMBINATIONVivian Cheung; Fiscal Year: 2008..It will also give insights into the pattern of human meiotic recombination, a key process that contributes to genetic diversity and to risk of non-disjunction. ..
- Epigenetic Regulation of the Embryonic Germ LineWilliam Kelly; Fiscal Year: 2009..This could also provide a better foundation for understanding how pluripotency is achieved and hopefully lead to therapies involving somatic stem cells. ..
- MOLECULAR GENETICS OF DOSAGE COMPENSATION IN DROSOPHILAVICTORIA MELLER; Fiscal Year: 2003..These similarities suggest that understanding the mechanism of dosage compensation in Drosophila has relevance to other systems of global transcriptional regulation. ..
- A NEW ANIMAL MODEL OF SCID FOR BIOMEDICAL RESEARCHKatheryn Meek; Fiscal Year: 2006..abstract_text> ..
- Gene Activation by Remote Transcriptional EnhancersDale Dorsett; Fiscal Year: 2004..This will help illuminate the basic mechanisms underlying gene expression defects that occur in some human diseases. ..
- Single Molecule Studies of DNA HelicasesPIERO BIANCO; Fiscal Year: 2007..abstract_text> ..
- DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORSAMY ARAI; Fiscal Year: 2004..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
- Laser Capture Microscopy and 2D-DIGE: Cancer ProteomicsWilliam Dynan; Fiscal Year: 2007..In the next phase, broader clinical utility will be demonstrated using a larger sample set. Changes in the pattern of protein expression will be identified. These changes can serve as clinically useful markers of tumor progression. ..
- Function and Mechanisms of the N-End Rule PathwayYong Tae Kwon; Fiscal Year: 2007..abstract_text> ..
- Mechanisms of Neurotransmitter-gated Ion ChannelsClaudio Grosman; Fiscal Year: 2007..abstract_text> ..
- Differential effects of TARPs on AMPA receptor subunitsAMY ARAI; Fiscal Year: 2008..unreadable] [unreadable]..
- Effects of prolonged seizures on GABAA receptor functionAndre Lagrange; Fiscal Year: 2008..This may help further our understanding of seizure initiation/abortion as well as normal GABAergic synaptic transmission. [unreadable] [unreadable]..
- INTERACTIONS OF DNA-PK WITH THE TRANSCRIPTION APPARATUSWilliam Dynan; Fiscal Year: 2004..Experiments in this proposal will provide definitive information about signaling interactions that occur between DNA-PK and the transcription apparatus. ..
- Involvement of Aldehydes in Alcohol AddictionWilliam McBride; Fiscal Year: 2009..Understanding the contribution of ACD and THIQs to high alcohol drinking could lead to the development of novel pharmaco-therapies for the treatment of alcoholism and alcohol abuse ..
- Proteomics of Ubiquitin-Dependent N-End Rule PathwayYong Tae Kwon; Fiscal Year: 2009..We will examine the physiological significance underlying the N-end rule dependent proteolysis of RGS4, -5, and -16, emerging in vivo N-end rule substrates. ..
- NEUROBIOLOGICAL FACTORS IN ADOLESCENT ALCOHOL DRINKINGWilliam McBride; Fiscal Year: 2009..Such information could be helpful in developing useful strategies for combating the major problem of adolescent alcohol drinking. ..
- Microarrays for Alzheimer's Disease Mouse ModelsP Reddy; Fiscal Year: 2003..The outcome of this proposed investigation will be useful in screening several mitochondrial antioxidants in AD transgenic mouse models as pre-clinical trials of AD patients...
- Epigenetic Control of Heterochromatin FormationRabindranath De La Fuente; Fiscal Year: 2010..abstract_text> ..