- Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation study
John C Boik
Graduate School of Biomedical Sciences, University of Texas, Houston, TX, U S A
Stat Med 27:1040-61. 2008
..The MixLow method can be used to quantify drug interactions in any fixed-ratio drug combination study that includes within-group and between-group replicates, and where responses follow a sigmoidal pattern...
- Drug interactions and the evolution of antibiotic resistance
Pamela J Yeh
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Microbiol 7:460-6. 2009
..Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as ..
- Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay
A A Ramos
CBMA Molecular and Environment Biology Centre Department of Biology, University of Minho, Braga, Portugal
Toxicol Lett 177:66-73. 2008
..These results also demonstrate that Hsp70 is not involved in the observed effects in HepG2...
- Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine
Equipe Stéroïdes et Système Nociceptif, Institut des Neurosciences Cellulaires et Integratives, Centre National de la Recherche Scientifique Université Louis Pasteur, 21 rue René Descartes, 67084 Strasbourg Cedex, France
Neuroscience 153:154-61. 2008
..Possibilities are opened for glycinergic agents and gelsemine utilization to stimulate selectively 3alpha,5alpha-THP biosynthetic pathways in diseases evoked by a decreased neurosteroidogenic activity of nerve cells...
- Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: antagonism by finasteride
Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
J Neurochem 83:1103-9. 2002
- Effect of venom from the scorpion Leiurus quinquestriatus on rat vascular aortic rings
Pediatric Intensive Care Unit, Division of Pediatrics, Soroka University Medical Center, Beer Sheva, Israel
J Basic Clin Physiol Pharmacol 14:309-21. 2003
..Calcium had little effect on the smooth muscle contractility of aortic rings incubated with the venom. No evidence was found to support nitric oxide synthesis after the long-term exposure of the rings to Lqh venom...
- Effects of Epigallocatechin-3-gallate on lead-induced oxidative damage
Shu Ting Yin
School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, PR China
Toxicology 249:45-54. 2008
..These observations suggest that EGCG is a potential complementary agent in the treatment of chronic lead intoxication through its antioxidative character...
- Mechanism of sulfite cytotoxicity in isolated rat hepatocytes
Department of Pharmacology and Toxicology, Faculty of Pharmacy, and Pharmaceutical Research Center, Shiraz University of Medical Sciences, Isfahan Road, Akbarabad, Shiraz 71345 1583, Iran
Chem Biol Interact 174:147-54. 2008
..Restoring GSH content of the cell or protein-SH groups by DTT can prevent sulfite cytotoxicity...
- Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes
Department of Pharmacy, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
J Appl Toxicol 28:329-36. 2008
- Iron-generated hydroxyl radicals kill retinal cells in vivo: effect of ferulic acid
H M Chao
Department of Ophthalmology, Veterans General Hospital, Taipei, Taiwan, Republic of China
Hum Exp Toxicol 27:327-39. 2008
..Importantly, FA protects iron toxicity perhaps by acting as a free radical scavenger. This provides an approach to the study and treatment of the iron-related disorders such as retained intraocular iron and Alzheimer disease...
- Specific blockage of ligand-induced degradation of the Ah receptor by proteasome but not calpain inhibitors in cell culture lines from different species
Richard S Pollenz
Division of Cell Biology, Microbiology and Molecular Biology, Department of Biology, University of South Florida, SCA 110, 4202 E Fowler Avenue, Tampa, FL 33620, United States
Biochem Pharmacol 74:131-43. 2007
- Estrogenic and toxic effects of polychlorinated biphenyls on cultured ovarian germ cells of embryonic chickens
Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No 268 Kaixuan Road, Hangzhou 310029, PR China
Reprod Toxicol 19:79-86. 2004
..These results indicate that PCBs exposure may interfere with ovarian germ cell proliferation and cause reproductive disorder via both toxic and estrogenic actions in embryonic chickens...
- Antagonistic effects of methyl-mercury and PCB153 on PC12 cells after a combined and simultaneous exposure
M V Vettori
Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy
Food Chem Toxicol 44:1505-12. 2006
- Paroxetine alters KCl- or ATP-induced contractile responses of isolated vas deferens in rats chronically treated with ethanol
Department of Pharmacology, School of Medicine, Karadeniz Technical University, TR 61187 Trabzon, Turkey
Pharmacol Res 49:51-7. 2004
..On the other hand, the potentiation of responses to contractile agents induced by PX can be partially considered as the result of inhibition of noradrenaline re-uptake...
- Standardized extracts of flavonoids increase the viability of PC12 cells treated with hydrogen peroxide: effects on oxidative injury
Neuroscience Research Center, Medical Faculty Charité, Humboldt University Berlin, Schumannstr 20 21, 10098 Berlin, Germany
Arch Toxicol 77:22-9. 2003
..Antioxidants prevented the oxidative injury of lipids more effectively than that of proteins...
- The insulin-suppressive effect of resveratrol - an in vitro and in vivo phenomenon
Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60 637 Wolynska 35, Poznan, Poland
Life Sci 82:430-5. 2008
..These observations point to the direct insulin-suppressive action of resveratrol in the rat...
- Cardiovascular effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) decisive for its therapeutic efficacy in sarin poisoning
Marloes J A Joosen
Research Group Medical Countermeasures, TNO Prins Maurits Laboratory, Lange Kleiweg 137, PO Box 45, 2280 AA Rijswijk, The Netherlands
Arch Toxicol 78:34-9. 2004
..In conclusion, the present results strongly indicate that bradycardia and hypotension induced by the peripheral adenosine A1 receptor play a prominent role in the therapeutic efficacy of CPA in cases of sarin poisoning...
- Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells
Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58202, USA
Toxicol Sci 102:254-61. 2008
..This study provides initial evidence that As(+3) and DA synergistically can cause enhanced toxicity in cultured neuronal cells possessing dopaminergic differentiation...
- Glyceryl trinitrate, a nitric oxide donor, abrogates ferric nitrilotriacetate-induced oxidative stress and renal damage
Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, New Delhi, India
Arch Biochem Biophys 418:71-9. 2003
..Overall, the study suggests that NO administration subsequent to Fe-NTA affords protection against ROS-mediated damage induced by Fe-NTA...
- Interaction between metamizol and tramadol in a model of acute visceral pain in rats
Department of Pharmacology, School of Odontology, University of Barcelona, Barcelona 08807, Spain
Eur J Pain 7:439-48. 2003
..Below the ED50 antagonism or additivity is present depending on the ratio of the combination. The mechanisms of the interaction remain unknown...
- Influence of dietary soy isoflavones on the accessory sex organs of the Wistar rat
UMR 0938 de Toxicologie Alimentaire, ENSBANA, 1 Esplanade Erasme, 21000, Dijon, France
Food Chem Toxicol 41:1175-83. 2003
- The protective effect of ascorbic acid derivative on PC12 cells: involvement of its ROS scavenging ability
Chang Bin Du
State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Meilong Road 130, Box 311, Shanghai 200237, China
Life Sci 74:771-80. 2003
..HPLC assay demonstrated that Asc2P6P could easily enter the cells and be converted into Asc persistently, which contributed to its distinguished role in protecting PC12 cells against H2O2-induced cytotoxicity...
- Synthesis and pharmacological characterization of a new benzoxazole derivative as a potent 5-HT3 receptor agonist
Pedro Luis López-Tudanca
Department of Research, FAES FARMA, S A, Máximo Aguirre 14, 48940 Leioa, Vizcaya, Spain
Bioorg Med Chem 11:2709-14. 2003
..Consequently, 10 acts as an in vivo 5-HT(3) antagonist inhibiting the BJR responses evoked by submaximal doses of 5-HT with an ID(50)=5.8 microg/kg iv...
- Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
Life Sci 74:2889-96. 2004
- Angiotensin IV stimulates the activity of tyrosine kinases in rat anterior pituitary gland acting via AT1-like receptors?
Department of Biochemistry, Institute of Physiology and Biochemistry, Institute of Endocrinology, Medical University of Łódź
J Physiol Pharmacol 55:107-11. 2004
..The involvement of a non-classic AT1-like receptor is suggested...
- Mechanisms for the vasodilations induced by Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta
Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
Life Sci 72:2659-67. 2003
..Bilobalide possesses the similar mechanisms for the vasodilation...
- Humic acid mediates iron release from ferritin and promotes lipid peroxidation in vitro: a possible mechanism for humic acid-induced cytotoxicity
Kuo Jang Ho
Graduated Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Republic of China
Arch Toxicol 77:100-9. 2003
..Therefore, HA coupled with released iron can disturb the redox balance and elicit oxidative stress within a biological system. This may be one of the most important mechanisms for HA-induced cytotoxicity...
- Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo
Ramamohana R Jonnala
Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912, USA
Life Sci 70:1543-54. 2002
- Oxalate modulates thiobarbituric acid reactive species (TBARS) production in supernatants of homogenates from rat brain, liver and kidney: effect of diphenyl diselenide and diphenyl ditelluride
Robson Luiz Puntel
Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Campus UFSM, Santa Maria, RS 97105 900, Brazil
Chem Biol Interact 165:87-98. 2007
..In addition, our results suggest that oxalate pro- and antioxidant activity in vitro could be related to its interactions with iron ions...
- A new bisphosphonate, YM529 induces apoptosis in HL60 cells by decreasing phosphorylation of single survival signal ERK
Kinki University School of Pharmaceutical Sciences, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
Life Sci 73:2655-64. 2003
..The results of this study also suggest that YM529 can be used as an anticancer agent, in addition to its use as a therapeutic agent to treat osteoporosis...
- Regional localisation of p53-independent apoptosis determines toxicity to 5-fluorouracil and pyrrolidinedithiocarbamate in the murine gut
S P Bach
Nuffield Department of Surgery, University of Oxford, Level 2, John Radcliffe Hospital, Oxford OX3 9DU, UK
Br J Cancer 95:35-41. 2006
- Effect of diphenyl diselenide, diphenyl ditelluride and ebselen on cerebral Na(+), K(+)-ATPase activity in rats
V C Borges
Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
Toxicology 215:191-7. 2005
..Cerebral Na(+), K(+)-ATPase is a potential molecular target for the toxic effect of organochalcogens and the inhibition may occur through a change in the crucial thiol groups of this enzyme...
- Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamilnadu, India
Life Sci 78:713-8. 2006
..The activity of ursolic acid (20 mg/kg) compares well with silymarin, a known hepatoprotective drug, and seems to be better in certain parameters. The protective effect of ursolic acid is probably related to its antioxidant activities...
- Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons
Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
Toxicol Sci 89:235-42. 2006
..We propose two independent neuronal death pathways by tributyltin; one is glutamate receptor-dependent cell death via ERK phosphorylation, and the other may be glutamate receptor-independent cell death via p38 activation...
- Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head and neck cancer cell lines
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Oncol Rep 14:1523-6. 2005
..We demonstrated that nimesulide inhibits the cytotoxic effect of cisplatin in HNSCC cells. Therefore, COX-2 inhibitor nimesulide may not be a good partner for cisplatin in combination therapy for cancer...
- Tumor necrosis factor-alpha protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction
Laboratorio di Biologia Molecolare and Unità di Reumatologia, Arcispedale S Maria Nuova, Reggio Emilia, Italy
J Rheumatol 33:1061-8. 2006
..To investigate the anti-apoptotic role of tumor necrosis factor-a (TNF-a) and its signaling pathways in cultured human fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis...
- Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity
Department of Otorhinolaryngology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
Tohoku J Exp Med 209:89-97. 2006
..These results suggest that calpain, rather than caspase, may be responsible for apoptosis induced by aminoglycoside. Thus, leupeptin may prevent hearing loss from aminoglycoside ototoxity...
- Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling
Biological Sciences and Bioengineering Program, Sabanci University, 34956 Orhanli, Tuzla Istanbul, Turkey
Toxicol Sci 90:120-32. 2006
..In this respect, resveratrol acting through MAP kinase pathways and specifically on JNK could have a role other than acting as an antioxidant-quenching reactive oxygen intermediate...
- Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells
Sung Hun Kim
Department of Orthopedic Surgery, College of Medicine, Pusan National University, Pusan, Korea
Toxicol Appl Pharmacol 215:198-207. 2006
..These data may provide a novel insight into potential therapeutic strategies for treatment of osteoporosis...
- Analysis of the mechanisms underlying the vasorelaxant action of angiotensin II in the isolated rat carotid
Carlos R Tirapelli
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo USP, SP, Brazil
Life Sci 78:2676-82. 2006
- Characterization of the inflammatory response to a highly selective PDE4 inhibitor in the rat and the identification of biomarkers that correlate with toxicity
Gregory N Dietsch
ICOS Corporation, Bothell, Washington 98021, USA
Toxicol Pathol 34:39-51. 2006
..The effect of IC542 on IL-6 release from rat leukocytes in vitro is consistent with the proinflammatory response observed in vivo and demonstrates species differences to PDE4 inhibition...
- Curcumin attenuates gentamicin-induced renal oxidative damage in rats
E O Farombi
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
Food Chem Toxicol 44:1443-8. 2006
..2 mM H2O2). Our data indicate that the natural antioxidant curcumin can be a potent protective agent against renal oxidative damage mediated by gentamicin...
- Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes
Department of Biochemistry, Vitebsk Medical University, Belarus
Exp Toxicol Pathol 53:227-33. 2001
..However, TUDCA coincubated with GCDCA protected the cells from the damaging effect of GCDCA at all measured parameters except the secretion of newly synthesized protein...
- Antisense oligonucleotide against GTPase Rab5b inhibits metabotropic agonist DHPG-induced neuroprotection
Andrea L H Arnett
Southern California Institute for Research and Education SCIRE, USA
Brain Res 1028:59-65. 2004
..These data suggest that neuroprotection by DHPG against NMDA-mediated injury may involve facilitation of NMDA receptor endocytosis likely stimulated by DHPG-induced increase in Rab5b synthesis...
- Captopril ameliorates toxicity induced by paraquat in mitochondria isolated from the rat liver
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Poursina Avenue, PO Box 13145 784, Tehran, Iran
Toxicol In Vitro 21:403-7. 2007
..The results indicate that captopril may prevent oxidative stress induced by paraquat...
- The green tea polyphenol (-)-epigallocatechin gallate attenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons
Y T Choi
Department of Psychiatry, Keimyung University School of Medicine, Taegu, Korea
Life Sci 70:603-14. 2001
..Taken together, the results suggest that EGCG has protective effects against betaA-induced neuronal apoptosis through scavenging reactive oxygen species, which may be beneficial for the prevention of Alzheimer's disease...
- Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells
Hsin Jung Wu
Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200, Chung Pei Road, Chung Li 32023, Taiwan, ROC
Toxicol In Vitro 21:335-42. 2007
..These results collectively suggest that oxidative stress plays a role in MG-induced cell injury, and that genistein blocks these effects by virtue of its antioxidant properties, consequently preventing cell apoptosis...
- Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
Ting Chao Chou
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Pharmacol Rev 58:621-81. 2006
- Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum
Pamela A Tamez
Program for Collaborative Research in the Pharmaceutical Sciences M C 877, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
J Ethnopharmacol 98:137-42. 2005
..5 to 37.8 nM. In summary, since activity in the mouse model was only moderate, cepharanthine may be of greater value as a modulator of resistance, capable of prolonging the clinical utility of chloroquine...
- Nitric oxide-dependent and -independent inhibition by lipopolysaccharide of phosphoinositide hydrolysis in vascular smooth muscle
Department of Hygiene and Preventive Medicine, School of Medicine, Yamagata University, Japan
Life Sci 69:2845-54. 2001
..These results suggest that NO is mainly involved in the inhibitory action of LPS on stimulated-PI hydrolysis in the early stage, while in the later stage, a factor(s) besides NO causes attenuation of the stimulated-PI hydrolysis...
- Role of the serotonin 5-HT2A receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethamphetamine
David V Herin
Department of Pharmacology and Toxicology, Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555 1031, USA
Psychopharmacology (Berl) 178:505-13. 2005
..Contradictory evidence exists regarding the role of the 5-HT(2A) receptor (5-HT(2A)R) in hyperactivity and hyperthermia elicited by the substituted amphetamine (+)-3,4-methylenedioxymethamphetamine...
- Involvement of the opioid system in the effects induced by nicotine on anxiety-like behaviour in mice
Graciela N Balerio
Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
Psychopharmacology (Berl) 181:260-9. 2005
..Recent studies have revealed the participation of the endogenous opioid system in several behavioural responses induced by nicotine including antinociception, rewarding properties, and physical drug dependence...
- The theaflavin fraction is responsible for the facilitatory effect of black tea at the skeletal myoneural junction
Drug Development Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
Life Sci 76:3081-8. 2005
..The findings suggest that Tfs have a potentiating effect on the contractile mechanism of skeletal muscle and that calcium and nitric oxide may modulate this action of Tfs...
- Histological and ultrastructural evidence for protective effects on aluminium-induced kidney damage by intraperitoneal administration of alpha-tocopherol
Department of Histology and Embryology, Faculty of Medicine, Pamukkale University, Ankara, Turkey
Int J Toxicol 26:95-101. 2007
..At the same time, the maintenance of a diet that is rich in vitamin E should be beneficial in the alleviation of Al toxicity...
- Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition
Jennette A Sakoff
Department of Medical Oncology, Newcastle Mater Misericordiae Hospital, Edith Street, 2298 Waratah, NSW, Australia
Cancer Chemother Pharmacol 53:225-32. 2004
..In this study the effect of combining PP inhibition with TS inhibition in two colorectal cell lines was examined...
- Parameters of drug antagonism: re-examination of two modes of functional competitive drug antagonism on intraocular muscles
Popat N Patil
The Ohio State University, Division of Pharmacology, College of Pharmacy LM Parks Hall, 500 W 12th Avenue, Columbus 43210, USA
J Pharm Pharmacol 56:1045-53. 2004
..the lipoid barrier correlated well to low IC50/KB ratios, as predicted by the classical theory of competitive drug antagonism. It was hypothesized that due to receptor biophase access, the reduction of the mechanical response of the ..
- Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents
K W Henry
Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
Antimicrob Agents Chemother 43:1968-74. 1999
..Drug-induced overexpression of efflux proteins represents a new and potentially general mechanism for drug antagonism.
- Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo
Department of Medicine, Division of Medical Oncology, Mount Sinai School of Medicine, New York, NY 10029 6547, USA
Blood 97:264-9. 2001
..Although in vitro data do not always translate to in vivo response, toxicity and potential drug antagonism may be diminished by decreasing the concentration of As(2)O(3) when given at the same time with therapeutic ..
- Optimal drug synergy in antimicrobial treatments
Joseph Peter Torella
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
PLoS Comput Biol 6:e1000796. 2010
..suggest that the optimal strategy for suppressing multi-drug resistance is not always to maximize synergy, and that in some cases drug antagonism, despite its weaker efficacy, may better suppress the evolution of multi-drug resistance.
- Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism
Ernst ter Haar
Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139, USA
Structure 18:1083-93. 2010
- Strategies to enhance immune function in hematopoietic transplantation recipients who have fungal infections
Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Bone Marrow Transplant 38:327-37. 2006
..patients with these infections and (4) the uncertain role of antifungal drug combinations and risk of drug antagonism complicating effective empiric-pre-emptive therapy...
- Behavioural and neurochemical abnormalities in mice lacking functional tachykinin-1 (NK1) receptors: a model of attention deficit hyperactivity disorder
Ting C Yan
Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Neuropharmacology 57:627-35. 2009
..behaviour of mice that lack functional substance P-preferring, tachykinin-1 receptors ((NK1R) either through drug antagonism or gene ablation) mimics that of wildtype mice that have been treated with an antidepressant drug...
- Antagonism of peroxisome proliferator-activated receptor gamma prevents high-fat diet-induced obesity in vivo
Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, 5 2 3 Toukoudai, Tsukuba shi, Ibaraki 300 2698, Japan
Biochem Pharmacol 72:42-52. 2006
..These data indicate that antagonism of PPARgamma using a synthetic ligand suppresses the increased adiposity observed in HF diet-induced obesity, and that a PPARgamma antagonist could possibly be developed as an anti-obesity drug...
- Developmental role of GABAB(1) receptors in Drosophila
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Brain Res Dev Brain Res 158:111-4. 2005
..Here we report on developmental deficits caused by embryonic Drosophila GABAB(1) RNAi and drug antagonism. Injecting embryos with CGP54626 (a GABAB receptor antagonist) reduced hatching and caused lethality...
- Treatment of hepatitis C and anemia in human immunodeficiency virus-infected patients
Douglas T Dieterich
Gastroenterology and Hepatology, Cabrini Medical Center, New York University School of Medicine, New York, New York 10003, USA
J Infect Dis 185:S128-37. 2002
..In addition, few instances of drug-drug antagonism have been reported among drugs used to treat each disease, although further study is necessary...
- Single and combined effects of selected pharmaceuticals at sublethal concentrations on multiple biomarkers in Carassius auratus
Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing, People s Republic of China
Ecotoxicology 21:353-61. 2012
..VTG induction suggested that caffeine and sulfamethoxazole may cause a slightly feminization effect...
- Atrial natriuretic peptide inhibits the expression of tissue factor and plasminogen activator inhibitor 1 induced by angiotensin II in cultured rat aortic endothelial cells
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Thromb Haemost 79:631-4. 1998
..ANP suppressed mRNA expressions of TF and PAI-1 induced by Ang II in a concentration-dependent manner. This suppression was accompanied by the decreased activities of TF and PAI-1...
- Formation of salts
Br Dent J 200:64-5; author reply 65. 2006
- Inhibitory effect of the newly synthesized pyridazinone derivative NZ-107 on bronchoconstriction induced by slow reacting substance of anaphylaxis in the guinea pig
Shiraoka Research Station of Biological Science, Nissan Chemical Ind, Ltd, Saitama, Japan
Jpn J Pharmacol 51:411-9. 1989
..From these results, NZ-107 is a selective inhibitor of the SRS-A response and may be useful in the therapy of bronchial asthma and other diseases in which the LTs are thought to be involved...
- Benzo[a]pyrene inhibits angiogenic factors-induced alphavbeta3 integrin expression, neovasculogenesis, and angiogenesis in human umbilical vein endothelial cells
Ching Hao Li
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Toxicol Sci 118:544-53. 2010
..These findings contribute to an understanding of the involvement of AhR agonists in vasculotoxicity...
- Vitamin C forestalls cigarette smoke induced NF-κB activation in alveolar epithelial cells
Department of Microbiology, University of Calcutta, 35 B C Road, Kolkata 700019, India
Toxicol Lett 220:76-81. 2013
..All these results demonstrate that vitamin C prevents CS(E)-induced NF-κB activation and thus it could be used for the prevention of CS-induced inflammatory diseases...
- Tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating GSH and cytokine levels
T P Hamsa
Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India
Exp Toxicol Pathol 64:307-14. 2012
..This study clearly demonstrates uroprotective role of T. cordifolia from CP induced toxicities by modulating GSH and pro-inflammatory cytokine levels...
- Enhanced anti-tumour effects of Vinca alkaloids given separately from cytostatic therapies
Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany
Br J Pharmacol 168:1558-69. 2013
..Here we studied whether this combination enables the optimal antitumour effects of Vinca alkaloids to be manifested...
- Autologous protein solution inhibits MMP-13 production by IL-1β and TNFα-stimulated human articular chondrocytes
Biomet Biologics, Warsaw, Indiana
J Orthop Res 29:1320-6. 2011
..The combination of anabolic and anti-inflammatory cytokines in the APS created from PRP may render this formulation to be a potential candidate for the treatment of inflammation in patients at early stages of OA...
- Influence of carbon dioxide insufflation of the neck on intraocular pressure during robot-assisted endoscopic thyroidectomy: a comparison with open thyroidectomy
Jie Ae Kim
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, Republic of Korea
Surg Endosc 27:1587-93. 2013
..Anesthesia, ventilatory strategy, intravenous infusions, and surgical positioning were standardized..
- Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-beta-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors
Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai, Japan
Eur J Pharmacol 395:107-12. 2000
..These data also reveal different antinociceptive mechanisms for DAMGO and for TAPA...
- The interactive effects of ammonia and microcystin on life-history traits of the cladoceran Daphnia magna: synergistic or antagonistic?
Jiangsu Province Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, Nanjing, China
PLoS ONE 7:e32285. 2012
..g., total offspring per female). In conclusion, the released toxins during the degradation of Microcystis blooms would result, according to our data, in substantially negative effect on D. magna...
- Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo
Liu Fang He
Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
Brain Res 1339:60-9. 2010
..Consequently, curcumin may have potential as a protective agent against immature white matter injury...
- Adjunctive antidepressant treatment for bipolar depression
Rif S El-Mallakh
N Engl J Med 357:615; author reply 615-6. 2007
- Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite
A M Filppula
Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland
Clin Pharmacol Ther 94:383-93. 2013
..Our findings indicate significant participation of CYP2C8 in the metabolism of imatinib in humans, and support involvement of an intestinal influx transporter in imatinib absorption...
- The biological action of hyaluronan on human osteoartritic articular chondrocytes: the importance of molecular weight
Laboratory of Investigation, Rheumatology Division, CHU Juan Canalejo, A Coruna, Spain
Clin Exp Rheumatol 22:307-12. 2004
..The aim of this study was to analyze the in vitro biological effects of HA on human OA chondrocytes and the impact of its molecular weight (MW) on those effects...
- A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores
John C Boik
Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
BMC Pharmacol 8:13. 2008
..Results were compared to models where explanatory variables were constructed using the pseudomolecule approach of Sheridan...
- Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011
Department of Behavioural Pharmacology, Gedeon Richter Ltd, Budapest H 1475, Hungary
Behav Pharmacol 15:253-62. 2004
..SB 277011, a highly selective dopamine D3 receptor antagonist, showed limited ability to influence the motor activity of rodents...
- Comparison of the dose response to levalbuterol with and without pretreatment with S-albuterol after methacholine-induced bronchoconstriction
Hengameh H Raissy
School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Pharmacotherapy 27:1231-6. 2007
..To determine the effect of S-albuterol on the dose response to levalbuterol in patients with moderate bronchoconstriction induced by a methacholine challenge...
- Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors
Medizinische Klinik III, Klinikum der Johann Wolfgang, Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt M, Germany
Rheumatol Int 22:60-7. 2002
..Here we investigated whether a folate excess impairs monocyte differentiation, a putative anti-inflammatory action of low-dose MTX...
- Hepatoprotective pyrrole derivatives of Lycium chinense fruits
Young Won Chin
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, South Korea
Bioorg Med Chem Lett 13:79-81. 2003
..1 microM (64.4 and 65.8%, respectively)...
- Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury
Department of Biology, Charleston Southern University, 9200 University Boulevard, Charleston, South Carolina 29406, USA
Toxicol Sci 102:433-43. 2008
- Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro
Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, C010 2 Chemoprevention, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Carcinogenesis 28:1471-7. 2007
..These data stress the need for elucidating mechanistic interactions for better predicting beneficial health effects of bioactive food components...
- Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model
Jukka P Rissanen
Pharmatest Services, Itäinen Pitkäkatu 4 C, 20520 Turku, Finland
Calcif Tissue Int 82:155-61. 2008
..As a conclusion, short-term changes in PINP predict long-term changes in trabecular bone parameters, suggesting that PINP is a reliable marker of bone formation in the rat OVX model...
- Phytoglycoprotein (75 kDa) suppresses release of histamine and expression of IL-4 and IFN- gamma in BPA-treated RBL-2H3 cells
Cheol Ho Park
Molecular Biochemistry Laboratory, Biotechnology Research Institute and Center for the Control of Animal Hazards Using Biotechnology BK 21, Chonnam National University, Gwang Ju, 300, Yongbong Dong, South Korea
Immunol Invest 39:171-85. 2010
..From point of view, we speculated that the phytoglycoprotein (75 kDa) is one of natural compounds that can block allergic-inflammation caused by BPA...
- Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes
Nutrition Croissance et Cancer, Emi 0211 Inserm, Faculte de Medecine, 2 Bd Tonnelle, 37032 Tours Cedex, France
Br J Pharmacol 139:816-22. 2003
..These findings have important implications for the extrapolation of in vitro experimental findings to the antiarrhythmic effects of DHA in vivo because, in vivo, peroxidation of DHA is unlikely to occur...
- Studies on drug interactions between esomeprazole, amoxicillin and clarithromycin in healthy subjects
Clinical Pharmacology, AstraZeneca Research and Development, Molndal, Sweden
Int J Clin Pharmacol Ther 44:119-27. 2006
..A combination of esomeprazole, amoxicillin and clarithromycin may be used for Helicobacter pylori eradication. We explored the potential for interactions between these drugs...
- Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes
Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Toxicol Lett 214:328-38. 2012
..EGCG effects were partially abolished in the presence of 1mM glutathione, suggesting they are particularly relevant to the in vivo conditions when glutathione is depleted by toxicant insults...
- Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation
Division of Nephrology, Tohoku University Graduate School of Medicine, Sendai, Japan
J Hypertens 30:1620-31. 2012
..Studies were designed to determine the effects of a specific TCC blocker, R(-) efonidipine [R(-)EFO], on the regulation of renal circulation...
- An in vitro investigation of synergy or antagonism between antimicrobial combinations against isolates from bacterial keratitis
Department of Ophthalmology, Royal Liverpool University Hospital, Liverpool, UK
Invest Ophthalmol Vis Sci 51:4151-5. 2010
..To investigate antimicrobial combinations for synergy or antagonism against isolates of Staphylococcus aureus and Pseudomonas aeruginosa...
- Pannexin1 drives multicellular aggregate compaction via a signaling cascade that remodels the actin cytoskeleton
Brian A Bao
Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, Rhode Island 02912, USA
J Biol Chem 287:8407-16. 2012
..Using a unique three-dimensional scaffold-free method to quantify multicellular interactions, this study shows that Panx1 is intimately involved in regulating intercellular biomechanical interactions pivotal in the progression of cancer...
- 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells
Hyun Joung Lim
Division of Cardiovascular Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, Republic of Korea
Toxicol Appl Pharmacol 223:20-7. 2007
..The present study reports for the first time that 15d-PGJ(2) induces HO-1 expression possibly using Nrf-2 pathway as a response to ROS in VSMCs...
- Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition
Stephen J McNally
Tissue Injury and Repair Group, University of Edinburgh, Chancellor s Building, Little France, Edinburgh EH16 4SB, UK
Int J Mol Med 19:165-72. 2007
- Predicting epistasis: an experimental test of metabolic control theory with bacterial transcription and translation
R C Maclean
Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
J Evol Biol 23:488-93. 2010
..Finally, this study highlights the fact that phenotypic manipulations of gene activity provide a powerful method for studying epistasis that complements existing genetic methods...
- The early toxicology of physostigmine: a tale of beans, great men and egos
National Poisons Information Service Birmingham Centre, City Hospital, Birmingham, UK
Toxicol Rev 25:99-138. 2006
..It is salutary to realise that the doses and dosage frequency of atropine together with the endpoints that define they are adequate were formulated by Fraser and others a century and a half ago...
- Interaction index and different methods for determining drug interaction in combination therapy
J J Lee
Department of Biostatistics, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
J Biopharm Stat 17:461-80. 2007
..We also provide S-PLUS/R code for each approach to facilitate the implementation of these commonly used methods...