Genomes and Genes
drug dose response relationship
Summary: The relationship between the dose of an administered drug and the response of the organism to the drug.
Publications357 found, 100 shown here
- Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondriaYin Guo
Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 277:13430-7. 2002..The caspase-2-released Cyt c is sufficient to activate the Apaf-caspase-9 apoptosome in vitro. In combination, our data suggest that caspase-2 is a direct effector of the mitochondrial apoptotic pathway...
- A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosisKoen Andries
Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
Science 307:223-7. 2005..Plasma levels associated with efficacy in mice were well tolerated in healthy human volunteers. Mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase...
- Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotoninR B Rothman
Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
Synapse 39:32-41. 2001..These results suggest that NE may contribute to the amphetamine-type subjective effects of stimulants in humans...
- The anti-angiogenic basis of metronomic chemotherapyRobert S Kerbel
Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, S 217, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
Nat Rev Cancer 4:423-36. 2004
- Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trialC Louvet
Service d Oncologie, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
J Clin Oncol 23:3509-16. 2005..Given the promising phase II results obtained with the Gem-oxaliplatin (GemOx) combination, we conducted a phase III study comparing GemOx with Gem alone in advanced pancreatic cancer...
- 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guidelineThomas J Smith
American Society of Clinical Oncology, Cancer Policy and Clinical Affairs, Alexandria, VA 22314, USA
J Clin Oncol 24:3187-205. 2006..Guided by the 1996 ASCO clinical outcomes criteria, the Update Committee formulated recommendations based on improvements in survival, quality of life, toxicity reduction and cost-effectiveness...
- Intensive lipid lowering with atorvastatin in patients with stable coronary diseaseJohn C LaRosa
State University of New York Health Science Center, Brooklyn, NY 11203, USA
N Engl J Med 352:1425-35. 2005..We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD)...
- Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interfS J Ajizian
Crippled Children s Foundation Research Center at Le Bonheur Children sMedical Center, Memphis, TN 38103, USA
J Infect Dis 179:939-44. 1999....
- Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignanciesM Hidalgo
Institute for Drug Development, Cancer Therapy and Research Center, and The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
J Clin Oncol 19:3267-79. 2001..To assess the feasibility of administering OSI-774, to recommend a dose on a protracted, continuous daily schedule, to characterize its pharmacokinetic behavior, and to acquire preliminary evidence of anticancer activity...
- Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemiaB J Druker
Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland 97201, USA
N Engl J Med 344:1031-7. 2001..Since tyrosine kinase activity is essential to the transforming function of BCR-ABL, an inhibitor of the kinase could be an effective treatment for CML...
- A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERKJorrit M Enserink
Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands
Nat Cell Biol 4:901-6. 2002..Moreover, in cell lines in which cAMP activates ERK, inhibition of PKA and Ras, but not Rap1, abolished cAMP-mediated ERK activation. We conclude that cAMP-induced regulation of ERK and activation of Rap1 are independent processes...
- Isolation of a tarantula toxin specific for a class of proton-gated Na+ channelsP Escoubas
Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Sophia Antipolis, Valbonne, France
J Biol Chem 275:25116-21. 2000..The new toxin is the first high affinity and highly selective pharmacological agent for this novel class of ionic channels. It will be important for future studies of their physiological and physio-pathological roles...
- The anti-inflammatory potential of berberine in vitro and in vivoChi Li Kuo
Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan, ROC
Cancer Lett 203:127-37. 2004..These anti-inflammatory effects paralleled to the in vivo results where berberine pretreatment of Wistar rat inhibited the production of exudates and PGE2 in carrageenan induced air pouch...
- Somatosensory cortical neuronal population activity across states of anaesthesiaIrina A Erchova
Cognitive Neuroscience Sector, International School for Advanced Studies, Via Beirut, 9, 34014 Trieste, Italy
Eur J Neurosci 15:744-52. 2002..The possible significance of the cyclic cortical responsiveness encountered during urethane anaesthesia to cortical processing in awake rats is considered...
- The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface areaClaire Monteiller
Institute of Occupational Medicine, Research Park North, Edinburgh, UK
Occup Environ Med 64:609-15. 2007....
- Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastasesS Boissier
, , Lyon, France
Cancer Res 60:2949-54. 2000..These results suggest, therefore, that BPs may be useful agents for the prophylactic treatment of patients with cancers that are known to preferentially metastasize to bone...
- In vitro toxicity of nanoparticles in BRL 3A rat liver cellsS M Hussain
Applied Biotechnology, Air Force Research Laboratory HEPB, Wright Patterson AFB, OH, USA
Toxicol In Vitro 19:975-83. 2005....
- Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosisR M Neer
Massachusetts General Hospital and Harvard Medical School, Boston, USA
N Engl J Med 344:1434-41. 2001..The 40-microg dose increased bone mineral density more than the 20-microg dose but had similar effects on the risk of fracture and was more likely to have side effects...
- Defining hormesisE J Calabrese
Environmental Health Sciences, University of Massachusetts, Amherst 01003, USA
Hum Exp Toxicol 21:91-7. 2002....
- NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microgliaLiya Qin
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
J Biol Chem 279:1415-21. 2004....
- The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimenElizabeth A Sconce
School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
Blood 106:2329-33. 2005..Based upon the data, a new warfarin dosing regimen has been developed. The validity of the dosing regimen was confirmed in a second cohort of patients on warfarin therapy...
- Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cellsBenson T Akingbemi
Center for Biomedical Research, The Population Council, 1230 York Avenue, New York, NY 10021, USA
Endocrinology 145:592-603. 2004..05) ng/ml in adulthood, implying that the perinatal period is a sensitive window of exposure to BPA. As BPA has been measured in several human populations, further studies are warranted to assess the effects of BPA on male fertility...
- Individualized patient dosing in phase I clinical trials: the role of escalation with overdose control in PNU-214936Jonathan D Cheng
Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
J Clin Oncol 22:602-9. 2004..PNU-214936 is a murine Fab fragment of the monoclonal antibody 5T4 fused to a mutated superantigen staphylococcal enterotoxin A (SEA)...
- ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trialMalcolm Ranson
Christie Hospital and Royal Eye Hospital, Manchester, United Kingdom
J Clin Oncol 20:2240-50. 2002..To investigate the tolerability, pharmacokinetics, and antitumor activity of the oral, selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 in patients with solid malignant tumors...
- Association of pesticide exposure with neurologic dysfunction and diseaseFreya Kamel
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 112:950-8. 2004..Major unresolved issues include the relative importance of acute and chronic exposure, the effect of moderate exposure in the absence of poisoning, and the relationship of pesticide-related neurotoxicity to neurodegenerative disease...
- Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channelsJoanna S Winks
1Ion Channel Pharmacology Group, IPC 388, Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent CT13 9NJ, United Kingdom
J Neurosci 25:3400-13. 2005....
- Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patientsBin Peng
Clinical Pharmacology, Novartis, One Health Plaza, Building 419, Room 2368, East Hanover, NJ 07936 1080, USA
J Clin Oncol 22:935-42. 2004..To evaluate the basic pharmacokinetic (PK) characteristics of imatinib mesylate and assess the relationship between the PK and pharmacodynamic (PD) properties of the drug...
- Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networksL A Campfield
Department of Metabolic Diseases, Hoffmann La Roche Incorporated, Nutley, NJ 07110, USA
Science 269:546-9. 1995..The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance...
- Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor typesJ Baselga
Vall d Hebron University Hospital, Barcelona, Spain
J Clin Oncol 20:4292-302. 2002....
- A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive mannerKembra L Howdeshell
Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 105:153-65. 2008..These data demonstrate that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture...
- Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroidsRobert F Lemanske
University of Wisconsin School of Medicine and Public Health, Madison, USA
N Engl J Med 362:975-85. 2010..For children who have uncontrolled asthma despite the use of low-dose inhaled corticosteroids (ICS), evidence to guide step-up therapy is lacking...
- Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern TaiwanH Y Chiou
School of Public Health, Taipei Medical University, Taipei, Taiwan
Am J Epidemiol 153:411-8. 2001..The multivariate-adjusted relative risks of developing TCC were 1.9, 8.2, and 15.3 for arsenic concentrations of 10.1-50.0, 50.1-100, and >100 microg/liter, respectively, compared with the referent level of < or =10.0 microg/liter...
- Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response controlTommy Pattij
Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Psychopharmacology (Berl) 191:587-98. 2007..Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect...
- Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticlesJae Hyuck Sung
Korea Environment and Merchandise Testing Institute, Incheon, Korea
Inhal Toxicol 20:567-74. 2008....
- The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: phase 1J Kanno
National Institute of Health Sciences, Tokyo, Japan
Environ Health Perspect 109:785-94. 2001..For the next phase of the OECD validation program, both models will be tested against a battery of weak, partial estrogen agonists...
- In vitro molecular mechanisms of bisphenol A actionYelena B Wetherill
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Reprod Toxicol 24:178-98. 2007....
- Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal culturesM A Lovell
Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, 101 Sanders-Brown Building, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536-0230, USA
Neurobiol Aging 22:187-94. 2001..Collectively, these data show that acrolein is increased in the brain in AD and demonstrate neurotoxicity mechanisms that might be important in the pathogenesis of neuron degeneration in AD...
- Differential effects of beta 1 and beta 2 subunits on BK channel activityPatricio Orio
Centro de Estudios Cientificos, Valdivia, Chile
J Gen Physiol 125:395-411. 2005..All allosteric coupling factors need to be increased in order to explain the observed effects when the alpha subunit is coexpressed with the beta2IR subunit...
- Nitric oxide priming protects nitric oxide-mediated apoptosis via heme oxygenase-1 inductionByung Min Choi
Medicinal Resources Research Center MRRC, School of Medicine, Wonkwang University, Chonbuk, South Korea
Free Radic Biol Med 34:1136-45. 2003..Our results presented here provide evidence to support the essential role of HO-1 in the cytoprotective function of NO priming...
- Subunit arrangement of gamma-aminobutyric acid type A receptorsS W Baumann
Department of Pharmacology, University of Bern, , CH-3010 Bern, Switzerland
J Biol Chem 276:36275-80. 2001..Our findings also favor an arrangement betaalphagammabetaalpha for the receptor composed of alpha, beta, and gamma subunits...
- Bayesian dose-finding in phase I/II clinical trials using toxicity and efficacy odds ratiosGuosheng Yin
Department of Biostatistics and Applied Mathematics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Biometrics 62:777-84. 2006..The method is illustrated with a real trial design for a breast medical oncology study...
- The extra domain A of fibronectin activates Toll-like receptor 4Y Okamura
Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Biol Chem 276:10229-33. 2001..These observations provided a mechanism by which EDA-containing fibronectin fragments promote expression of genes involved in the inflammatory response...
- Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemiaR J Kreitman
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA
N Engl J Med 345:241-7. 2001..We tested the safety and efficacy of an immunotoxin directed against a surface antigen that is strongly expressed by leukemic hairy cells...
- A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignanciesCarol Aghajanian
The Developmental Chemotherapy Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 8:2505-11. 2002..v. bolus for 2 weeks, followed by a 1-week recovery period in patients with advanced solid tumor malignancies...
- A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002Duk Hee Lee
Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin dong, Jung Gu, Daegu, Korea 700 422
Diabetes Care 29:1638-44. 2006..Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes...
- Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisoloneL Qin
Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China
Bone 39:863-71. 2006....
- Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4Shuk Mei Ho
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
Cancer Res 66:5624-32. 2006..In total, these findings indicate that low-dose exposures to ubiquitous environmental estrogens affect the prostate epigenome during development and, in so doing, promote prostate disease with aging...
- Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetesYoshinori Miyazaki
University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, Texas 78229 3900, USA
Diabetes Care 25:517-23. 2002..To investigate the dose-response effects of pioglitazone on glycemic control, insulin sensitivity, and insulin secretion in patients with type 2 diabetes...
- Dose-finding in phase I clinical trials based on toxicity probability intervalsYuan Ji
Department of Bioinformatics and Computational Biology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
Clin Trials 4:235-44. 2007..Most phase I clinical trials conducted at the M. D. Anderson Cancer Center use the algorithmic 3 + 3 design, despite the availability of more advanced model-based designs such as the continual reassessment method...
- Exogenous arginine in sepsisYvette C Luiking
Center for Translational Research on Aging and Longevity, Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Crit Care Med 35:S557-63. 2007..We recently performed a study indicating that arginine can be given to septic patients without major effects on hemodynamics, suggesting that more studies can be conducted on the effects of arginine supplementation in septic patients...
- Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjectsCynthia A Guzzo
Merck Research Laboratories, Blue Bell, Pennsylvania, USA
J Clin Pharmacol 42:1122-33. 2002..This study demonstrated that ivermectin is generally well tolerated at these higher doses and more frequent regimens...
- Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytesYun Hyun Huh
Department of Life Science, National Research Laboratory, Kwangju Institute of Science and Technology, Gwangju 500 712, Korea
J Biol Chem 278:9691-7. 2003..Our results indicate that EGF in articular chondrocytes stimulates COX-2 expression and PGE(2) production via ERK and p38 kinase signaling in association with differentiation status...
- The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertensionTakuya Watanabe
Health Care Products Laboratories, Kao Corporation, Tokyo, Japan
Clin Exp Hypertens 28:439-49. 2006..There was no difference in body mass index and pulse rate between groups, nor were there any apparent side effects. Thus, CGA from GCE is effective in decreasing blood pressure and safe for patients with mild hypertension...
- Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblastsU Mayr-Wohlfart
Orthopaedic Department RKU, University of Ulm, Ulm, Germany
Bone 30:472-7. 2002..Taken together, our data establish that human osteoblasts respond to VEGF-A, suggesting a functional role for this growth factor in bone formation and remodeling...
- Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 1: Identification and characterizationChiara Groppo
Interdepartmental Center G Scansetti for Studies on Asbestos and Other Toxic Particulates, Department of Mineralogical and Petrological Sciences, Via Pietro Giuria, University of Torino, Torino, Italy
J Toxicol Environ Health A 68:1-19. 2005..Data show that chemical composition, form, durability, and cell toxicity indicate balangeroite as a potentially harmful fibrous mineral that needs to be examined by further chemical and cellular tests...
- Vitamin E treatment in pediatric obesity-related liver disease: a randomized studyPietro Vajro
Department of Pediatrics, University of Naples Federico II, Italy
J Pediatr Gastroenterol Nutr 38:48-55. 2004..The authors compared the effect of vitamin E and weight loss on transaminase values and on ultrasonographic bright liver in a controlled group of children with obesity-related liver dysfunction...
- Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunineV K Ngan
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA
Mol Pharmacol 60:225-32. 2001..3 +/- 0.1 microM), and more than 10-fold lower for vinblastine (130 +/- 7 nM), suggesting that intracellular binding reservoir(s) may be partially responsible for vinflunine's high efficacy and minimal side effects...
- Corticotropin-releasing factor inhibits maternal aggression in miceStephen C Gammie
Neuroscience Training Program, Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
Behav Neurosci 118:805-14. 2004..These findings suggest that decreased CRF is necessary for maternal aggression and may act by altering brain activity in response to an intruder...
- TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]iDirk Prawitt
Children s Hospital, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
Proc Natl Acad Sci U S A 100:15166-71. 2003..TRPM5 can be activated physiologically by inositol 1,4,5-trisphosphate-producing receptor agonists, and it may therefore couple intracellular Ca2+ release to electrical activity and subsequent cellular responses...
- Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in ratsA D Le
Department of Neuroscience, Center for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada, M5S 2S1
Psychopharmacology (Berl) 179:366-73. 2005..We also tested the effect of lofexidine and yohimbine on alcohol self-administration. Lofexidine is used clinically for treating opiate withdrawal symptoms and yohimbine induces stress-like responses in humans and non-humans...
- Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophagesY C Liang
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei
FEBS Lett 496:12-8. 2001..These results suggested that these three flavonoids might act as allosteric effectors and were able to bind to PPAR gamma and activate it, but its binding site might be different from the natural ligand BRL49653...
- In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9)X Wen
Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Br J Clin Pharmacol 52:547-53. 2001..Co-administration of high doses of valproic acid with drugs that are primarily metabolized by CYP2C9 may result in significant drug interactions...
- The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutationsEckhard Ficker
Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
J Biol Chem 277:4989-98. 2002..Our findings represent a first step toward the design of pharmacological chaperones that will rescue HERG K(+) channels without block...
- Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancerEardie A Curry
Department of Pharmacy Practice, Purdue University, Indianapolis, IN, USA
Invest New Drugs 22:299-305. 2004..Feverfew has been used extensively without any formal pharmacokinetic analysis. A Phase I trial was conducted to evaluate the pharmacokinetics and toxicity of parthenolide given as a component of "feverfew."..
- Gemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non-small-cell lung cancer: A randomized phase III study of the Italian Lung Cancer ProjectL Crino
Department of Medical Oncology, Policlinico Hospital, Perugia, Italy
J Clin Oncol 17:3522-30. 1999..The end points were the evaluation of quality of life (QoL), response rates, survival, and toxicity...
- Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profilingShang Lun Chiang
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan, ROC
Toxicol Sci 100:66-74. 2007..The findings identified that 12 susceptible genes can potentially serve as biomarkers of arecoline-induced damage in betel chewers...
- Prostate cancer risk and consumption of fish oils: a dietary biomarker-based case-control studyA E Norrish
Department of Community Health, University of Auckland, New Zealand
Br J Cancer 81:1238-42. 1999..These analyses support evidence from in vitro experiments for a reduced risk of prostate cancer associated with dietary fish oils, possibly acting via inhibition of arachidonic acid-derived eicosanoid biosynthesis...
- Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxinV P Markowski
Department of Psychology, University of Southern Maine, Portland, Maine, USA
Environ Health Perspect 109:621-7. 2001..71 ng/kg with a 95% lower bound of 0.60. These values should be viewed from the perspective of current human body burdens, whose average value, based on TCDD toxic equivalents, has been calculated as 13 ng/kg...
- Molecular imaging of antiangiogenic agentsShazza Rehman
Cancer Research UK, Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, United Kingdom
Oncologist 10:92-103. 2005..This review briefly discusses the role of molecular imaging in general, and DCE-MRI in particular, in relation to treatment with antiangiogenic agents and highlights some of the difficulties encountered in this area...
- Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1Elsa Phillips
Novartis Institutes of Biomedical Research, Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, United Kingdom
J Biol Chem 279:17165-72. 2004..The rat M547L mutation reduced the affinity of RTX binding. Thus, amino acids within the S2-S4 region are important sites of agonist and antagonist interaction with TRPV1...
- Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell linesAzhar R Hussain
Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
Mol Cancer Ther 7:3318-29. 2008..These findings also raise the possibility that incorporation of curcumin in treatment regimens may provide a novel approach for the treatment of Burkitt's lymphomas and provide the molecular basis for such future translational efforts...
- VEGF-A and PlGF-1 stimulate chemotactic migration of human mesenchymal progenitor cellsJörg Fiedler
Orthopaedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
Biochem Biophys Res Commun 334:561-8. 2005....
- Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in miceW V Welshons
Department of Veterinary Biomedical Sciences, University of Missouri Columbia 65211, USA
Toxicol Ind Health 15:12-25. 1999..The studies and strategies we describe are important in developing criteria for a tiered testing system for the detection of estrogenic chemicals as well as endocrine-disrupting chemicals with different modes of action...
- Metallothionein is a potential negative regulator of apoptosisRyuya Shimoda
National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 73:294-300. 2003..965). These suggest that MT may play a role in regulating apoptosis and that modulating MT expression may provide a strategy for altering cellular resistance to chemotherapeutic compounds...
- Reproductive effects of long-term exposure to Bisphenol A in the fathead minnow (Pimephales promelas)P Sohoni
Department of Biological Sciences, Brunel University, Uxbridge, UB8 3PH
Environ Sci Technol 35:2917-25. 2001..The results demonstrate that BPA acts as a weak estrogen to fish when administered via the water, with effects on breeding at and above 640 micrograms/L...
- Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous releaseJun Xu
Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, California, USA
Nat Neurosci 12:759-66. 2009..These data suggest that Syt1 controls both evoked and spontaneous release at a synapse as a simultaneous Ca2+-dependent activator and clamp of exocytosis...
- Sodium arsenite impairs insulin secretion and transcription in pancreatic beta-cellsAndrea Díaz-Villaseñor
Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico
Toxicol Appl Pharmacol 214:30-4. 2006..Our data suggest that arsenic may contribute to the development of diabetes mellitus by impairing pancreatic beta-cell functions, particularly insulin synthesis and secretion...
- Intracerebroventricular administration of Shiga toxin type 2 induces striatal neuronal death and glial alterations: an ultrastructural studyJorge Goldstein
Laboratorio de Fisiopatogenia, Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Brain Res 1161:106-15. 2007..The toxin may affect brain neuroglial cells without the involvement of proinflammatory or systemic neurotoxic elements...
- Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis ratsYong Wang
Department of Traditional Chinese Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China
J Ethnopharmacol 98:37-43. 2005..01). In conclusion, SN decreases the mRNA expression of TNF-alpha and IL-1beta by inhibiting the NF-kappaB binding activity, which is mediated through up-regulating the IkappaB-alpha expression of PMs and synoviocytes in AA rats...
- Taking glucocorticoids by prescription is associated with subsequent cardiovascular diseaseLi Wei
Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
Ann Intern Med 141:764-70. 2004..Glucocorticoids have adverse systemic effects, including obesity, hypertension, and hyperglycemia, that may predispose to cardiovascular disease. The effect of glucocorticoid use on cardiovascular disease has not been quantified...
- Last in, first out: the role of cofactor binding in flavodoxin foldingYves J M Bollen
Department of Agrotechnology and Food Sciences, Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, NL 6703 HA Wageningen, The Netherlands
J Biol Chem 280:7836-44. 2005..The stability of holoflavodoxin is so high that even under strongly denaturing conditions FMN needs to be released first before global unfolding of the protein can occur...
- P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicityG R Lankas
Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Toxicol Appl Pharmacol 143:357-65. 1997....
- Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathySarah J L Flatters
Anaesthesia Research Unit, McIntyre Building, Room 1213, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada H3G 1Y6
Pain 109:150-61. 2004..These data suggest that T-type calcium channels may play a role in chemotherapy-induced neuropathy and moreover identify ethosuximide as a new potential treatment for chemotherapy-induced pain...
- Spontaneous channel activity of the inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Application of allosteric modeling to calcium and InsP3 regulation of InsP3R single-channel gatingDon On Daniel Mak
Department of Physiology, B39 Anatomy Chemistry, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
J Gen Physiol 122:583-603. 2003..The validity of this model was established by its successful quantitative prediction of channel behavior after it had been exposed to ultra-low bath [Ca2+]...
- Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperatureAlla Y Rudaya
Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, Arizona 85013, USA
Am J Physiol Regul Integr Comp Physiol 289:R1244-52. 2005..The present investigation identifies experimental conditions to study LPS-induced mono-, bi-, and polyphasic fevers and late hypothermia in mice and provides detailed characteristics of these responses...
- Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the ratMin Zhang
Department of Psychiatry, University of Wisconsin Madison Medical School, 53715, USA
Behav Neurosci 117:202-11. 2003....
- Induction of oxidative stress by bisphenol A in the epididymal sperm of ratsK C Chitra
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
Toxicology 185:119-27. 2003..In conclusion, the adverse effect of bisphenol A on male reproduction may be due to induction of oxidative stress in sperm...
- Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trialJaap Verweij
Department of Medical Oncology, Erasmus University Medical Centre, Groene Hilledijk 301, 3075 EA Rotterdam, Netherlands
Lancet 364:1127-34. 2004..Imatinib is approved worldwide for use in gastrointestinal stromal tumours (GIST). We aimed to assess dose dependency of response and progression-free survival with imatinib for metastatic GIST...
- Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic TherapyJack Hirsh
Henderson Research Centre, 711 Concession St, Hamilton, ON L8V 1C3, Canada
Chest 126:188S-203S. 2004..The synthetic pentasaccharide fondaparinux is a promising new antithrombotic agent for the prevention and treatment of venous thromboembolism...
- ProJuvant (Pluronic F127/chitosan) enhances the immune response to intranasally administered tetanus toxoidM A Westerink
Department of Medicine, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614, USA
Vaccine 20:711-23. 2001..The results of these studies suggest that F127/chitosan represents a novel mucosal vaccine delivery system, consisting of two components, that appear to exert an additive or synergistic effect on the immune response...
- Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumorsJosep Tabernero
Medical Oncology Department, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, corrected Barcelona, Spain
J Clin Oncol 26:1603-10. 2008..In order to identify a rationally based dose and schedule for cancer treatment, we have conducted a tumor pharmacodynamic phase I study in patients with advanced solid tumors...
- Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia miltiorrhiza-induced apoptosis in human hepatoma HepG2 cellsJ Liu
Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
Life Sci 69:1833-50. 2001..Taken together, our results suggest that SM deplete intracellular thiols, which, in turn, causes MPT and subsequent increase in ROS generation, and eventually apoptotic cell death...
- Distinct role for microglia in rotenone-induced degeneration of dopaminergic neuronsHui Ming Gao
Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Neurosci 22:782-90. 2002..The results of this study should advance our understanding of the mechanism of action for pesticides in the pathogenesis of Parkinson's disease...
- NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenograftsKaruppaiyah Selvendiran
Davis Heart and Lung Research Institute and Comprehensive Cancer Center, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
Cell Cycle 7:81-8. 2008..Thus, NCX-4016 appears to be a potential therapeutic agent for treating recurrent human ovarian carcinoma...
- Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmiumDaniel Stewart
Department of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
J Biol Chem 278:2396-402. 2003..Together, these results indicate that Nrf2 is targeted for rapid degradation by the ubiquitin-proteasome pathway and that cadmium delays the rate of Nrf2 degradation leading to ho-1 gene activation...
- Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'George L Drusano
Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208, USA
Nat Rev Microbiol 2:289-300. 2004
- Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAXP P Ruvolo
Shands Cancer Center and the Department of Medicine, University of Florida, Gainesville, Florida 32610 0232, USA
J Biol Chem 276:11754-8. 2001..Collectively, these findings suggest a novel role for ceramide in the regulation of protein synthesis and apoptosis...
- Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson diseaseD C Wu
Department of Neurology, Columbia University, New York, New York 10032, USA
J Neurosci 22:1763-71. 2002..This study demonstrates that microglial-related inflammatory events play a significant role in the MPTP neurotoxic process and suggests that minocycline may be a valuable neuroprotective agent for the treatment of PD...
- Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiationYoh Ichi Seki
Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278 0022, Japan
Proc Natl Acad Sci U S A 99:13003-8. 2002..Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance...
- Differential effects of psychomotor stimulants on attentional performance in rats: nicotine, amphetamine, caffeine and methylphenidateL Bizarro
Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, UK
Behav Pharmacol 15:195-206. 2004..The findings with methylphenidate support the potential value of the 5-CSRTT for testing drugs that may be useful in the treatment of attention deficit hyperactivity disorder...
- Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulinHassan Lemjabbar
Biomedical Sciences Program, Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143, USA
J Biol Chem 278:26202-7. 2003..These results shed light on the pathogenesis of lung cancer, suggest novel drug targets for the reduction of cancer risk in smokers, and provide insight into how EGFR integrates responses to diverse noxious stimuli...
- HER2/neu and dietary fat: interactions in breast cancerLisa Yee; Fiscal Year: 2006..unreadable] [unreadable]..
- Cannabinoid Regulation of Basal Ganglia Glutamate and GABASCOTT RAWLS; Fiscal Year: 2007..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
- Neuropharmacology of Tramadol: Clinical Efficacy and Abuse PotentialWILLIAM WALTON STOOPS; Fiscal Year: 2010..Developing analgesics with reduced abuse potential may reduce the prevalence of prescription opioid misuse and subsequent opioid use disorders. ..
- DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCESJANICE WAGNER; Fiscal Year: 2006..unreadable] [unreadable]..
- Can beta-lactam antibiotics decrease morphine physical dependence?SCOTT RAWLS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Laboratory Models of Cocaine Self-AdministrationThomas Newton; Fiscal Year: 2008..abstract_text> ..
- Tissue engineering of small diameter vascular graftChangyi Chen; Fiscal Year: 2006..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
- INNOVATIVE BIOMONITORING FOR LEAD IN SALIVACharles Timchalk; Fiscal Year: 2006..It is reasonable to speculate that once this model system has been adequately validated it can readily be employed to screen sensitive populations (e.g. children) that are at greatest risk from chronic Pb exposure. ..
- ROS and NO interaction in the PVN during hypertension?CARRIE NORTHCOTT; Fiscal Year: 2006..unreadable] [unreadable]..
- Efficacy and Safety of Baclofen for Alcohol DependenceJames Garbutt; Fiscal Year: 2006..Several studies also have found that baclofen reduces self-reported anxiety and craving; thus, the proposed study will assess baclofen's ability to reduce these symptoms as well. ..
- SELENIUM-INDUCED GLAUCOMAW Stamer; Fiscal Year: 2006..abstract_text> ..
- Role of oleoylethanolamide in the control of food intakeDaniele Piomelli; Fiscal Year: 2010....
- ITO IN DOGS WITH INHERITED VENTRICULAR ARRHYTHMIASBruce Kornreich; Fiscal Year: 2005..abstract_text> ..
- Molecular Surgeon Symposium on Vascular Injury, RepairChangyi Chen; Fiscal Year: 2005..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2009..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
- Development of Selective Nanoporous Sorbents for Radionuclide DecorporationCharles Timchalk; Fiscal Year: 2008..abstract_text> ..
- ENTEROSTATIN REGULATION OF FAT INTAKEDavid York; Fiscal Year: 2005..Fourth they will identify the neuropathways responsive to enterostatin by immunohistochemistry and tract tracing techniques. Finally these pathway responsiveness to dietary fat will be evaluated. ..
- Medication Development for Marijuana RelapseMargaret Haney; Fiscal Year: 2008..abstract_text> ..
- Treatment of Severe Persistent AsthmaROBERT LEMANSKE; Fiscal Year: 2007..abstract_text> ..
- CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE TRAININGDalane Kitzman; Fiscal Year: 2007..abstract_text> ..
- EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONEJoel Finkelstein; Fiscal Year: 2008..Without continued K24 support, I will need to increase my clinical activities, reduce my research time, and forego training of new clinical investigators. ..
- Antioxidant Defense System and Leydig Cell AgingHaolin Chen; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Post-transcriptional Regulation Requires Phosphorylation of HuR in GliomaLOUIS NABORS; Fiscal Year: 2009..at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
- Pharmacogenetic Optimization of Anticoagulation TherapyNita Limdi; Fiscal Year: 2007..With the award of the K23 grant, structured training, guidance of mentors, environment and institutional support provided by the University, I will develop the skills necessary for a productive career in pharmacogenetics research. ..
- ALCOHOL EFFECT ON HUMAN LACTATION AND INFANT BEHAVIORJULIE MENNELLA; Fiscal Year: 2007..AIM 3: To explore the role of early experiences with ethanol in mothers' milk and the emotional context of such experiences, on the recognition of, and preference for, the sensory properties of ethanol ..
- Choline Tracers for Imaging of CancerTimothy DeGrado; Fiscal Year: 2007..abstract_text> ..
- Genetics and cardiovascular reactivity in young twinsYanbin Dong; Fiscal Year: 2005....
- A Decision Support Tool for Adult Sickle Cell Emergency Department PatientsPaula Tanabe; Fiscal Year: 2010..This knowledge will position the candidate to launch a research career as an investigator who will conduct projects aimed at scientifically evaluating mechanisms to improve the care of persons with SCD in the ED setting. ..
- PAIN AND ANALGESIC RESPONSE--SEX AND HORMONE VARIATIONSSandra Comer; Fiscal Year: 2002..In addition, they will more carefully examine sex differences in analgesic response to butorphanol and morphine, two agonists with differing selectivities for mu and kappa opioid receptors. ..
- PET TRACERS FOR MYOCARDIAL FATTY ACID OXIDATIONTimothy DeGrado; Fiscal Year: 2003....
- 2003 Conference Pan-American Society Pigment Cell ReseaRuth Halaban; Fiscal Year: 2003..3. To provide partial support to students and junior faculty to attend the meeting. They request funds for the 2003 meeting as well as for the 2 subsequent PASPCR annual meetings in years 2004 and 2006. ..
- CONTROL OF SLEEP AND AROUSALNOOR ALAM; Fiscal Year: 2003..These pharmacological manipulations and analytical procedures will help understanding of the adenosinergic and GABAergic mechanisms that shape the discharge patterns of the MBF neurons across the sleep-waking cycle. ..
- SYNOVIOCYTE RHO-TYPE GTPASES IN CARTILAGE DESTRUCTIONLeslie Crofford; Fiscal Year: 2002..Ultimately, we will determine the effects of the Rho-type GTPases on synoviocyte adherence to and migration over articular cartilage, production of MMPs, and destruction of the cartilage matrix. ..
- Estrogenic LXR Alpha Response /Cholesterol HomeostasisPhillip Kramer; Fiscal Year: 2003..abstract_text> ..
- Opioid Antagonist Discrimination: A Model of WithdrawalAlison Oliveto; Fiscal Year: 2011..This paradigm provides a sensitive, standard, objective, systematic method to identify potential agents for enhancing OW treatment which can be examined further in a detox protocol. ..
- Estrogen and the Aging Blood Brain BarrierOAK CHI; Fiscal Year: 2002..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
- Design and Development of Pharmacotherapies for Treating Stimulant AbuseFrank Ivy Carroll; Fiscal Year: 2010..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2010..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
- POPULATION BIOLOGY OF BACTERIAL VIRUSES AND PLASMIDSBruce Levin; Fiscal Year: 2002....
- CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMAROBERT LEMANSKE; Fiscal Year: 2001..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
- Working memory deficits following brain traumaPramod Dash; Fiscal Year: 2009..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
- FATTY ACIDS AND PPARS IN BREAST CANCER PREVENTIONLisa Yee; Fiscal Year: 2005..Yee the training required to become an independent clinician scientist in the field of preventive oncology. ..
- EXERCISE INTOLERANCE IN ELDERLY DIASTOLIC HEART FAILUREDalane Kitzman; Fiscal Year: 2004..abstract_text> ..
- RENAL INJURY AND ADAPTATION TO HEME PROTEINSKarl Nath; Fiscal Year: 2001..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
- ETHANOL EFFECTS ON VIGILANCEGALEN WENGER; Fiscal Year: 2001..It is hoped that these studies will lead to a further understanding of the relationship between ethanol usage and vigilance and the impact of ethanol use on performance and safety in the workplace. ..
- Plasminogen activators and cerebral ischemic injuryWilliam M Armstead; Fiscal Year: 2010....
- Clofarabine: Cytarabine Activation for Leukemia ResponseStefan Faderl; Fiscal Year: 2004..abstract_text> ..
- Disulfiram for Cocaine Abuse in Metadone - PatientsAlison Oliveto; Fiscal Year: 2010..The prognostic relevance of other factors (e.g., sex, discounting behavior) will also be examined. ..
- Discriminative Stimulus Effects of Alcohol in MiceWouter Koek; Fiscal Year: 2007..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
- Biosynthesis of Hypotensive Phosphonopeptide Natural ProductsBrian O Bachmann; Fiscal Year: 2010..Metalloproteinase inhibitors have potential to treat a large number of human illnesses including hypertension, cancer and osteoarthritis, among others. ..
- Effects of Androgens and Cannabinoids on LearningSTUART LEONARD; Fiscal Year: 2005..These results will provide, for the first time, information regarding the interactive effects of testosterone and THC on cognitive behavior. ..
- Characterization of a novel brain cannabinoid ligandDaniele Piomelli; Fiscal Year: 2010..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
- Genetic Regulation of Seizure-Induced NeurogenesisPAULA SCHAUWECKER; Fiscal Year: 2004..abstract_text> ..
- POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAINWilliam Armstead; Fiscal Year: 2005..These studies may lead to therapies for brain injured children. ..
- International Multi-Center ADHD Genetics ProjectStephen Faraone; Fiscal Year: 2007..abstract_text> ..
- NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTIONFrank Carroll; Fiscal Year: 2008..abstract_text> ..
- Cognitive-Behavioral Therapy for Pathological GamblingJon Grant; Fiscal Year: 2008..This award would provide me with the necessary background for further studies in the treatment of pathological gambling and the training for an independent patient-oriented research career. ..
- CADHERIN DYNAMICS AND GLAUCOMAW Daniel Stamer; Fiscal Year: 2010..Results obtained from these investigations will provide a basic understanding of the role of cadherin proteins in aqueous outflow resistance and uncover novel therapeutic targets for glaucoma therapy. ..
- LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGEDNunzio Pomara; Fiscal Year: 2005..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..
- ASTHMA CLINICAL RESEARCH NETWORKROBERT LEMANSKE; Fiscal Year: 2002....
- Defibrotide for the treatment of severe hepatic veno-cc*Paul Richardson; Fiscal Year: 2007..Abstract Not Provided ..
- GM1 Ganglioside Effects on Parkinson's DiseaseJay Schneider; Fiscal Year: 2007..Working hypothesis: Long-term GM1 use will stabilize symptoms or slow the progression of symptoms in PD patients and this may be accompanied by reduced loss of striatal DA terminals over time. [unreadable] [unreadable]..
- STRAIT: Simulation Training for Rapid Assessment and Improved TeamworkMatthew Weinger; Fiscal Year: 2007..Successful demonstration of STRAIT'S effectiveness will lead to rapid dissemination of the methods to other clinical handoff situations. [unreadable] [unreadable] [unreadable]..
- Dietary fat modulated metabolic fate of fluorantheneAramandla Ramesh; Fiscal Year: 2003..abstract_text> ..
- FOREBRAIN AND HINDBRAIN MECHANISMS OF SALT APPETITEROBERT THUNHORST; Fiscal Year: 2005....
- Optimizing use of androgen deprivation therapy for prostate cancerVahakn B Shahinian; Fiscal Year: 2010..POP dominant) on care of men on ADT. ..
- TESTOSTERONE FOR PREVENTION OF FRACTURE IN MENAnne Kenny; Fiscal Year: 2005....
- Renal Control of Blood Pressure in Early DiabetesMichael Brands; Fiscal Year: 2007..whether increased SOD1 in transgenic mice protects against hypertension similar to tempol; d. the role of NADPH oxidase, by measuring p22 phox expression and the effect of apocynin. ..
- SYNERGISM AND MEDICATIONS DEVELOPMENT FOR DRUG ABUSERonald Tallarida; Fiscal Year: 2004..This guide is the newest aim of this revised application. ..
- Chemoprevention of colon cancer via neonatal imprintingAramandla Ramesh; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Treatments for Psychogenic Nonepileptic Seizures (NES)W LaFrance; Fiscal Year: 2007..abstract_text> ..
- Clinical Activity of 17-AAG in LymphomaAnas Younes; Fiscal Year: 2007..In Aim 3 we will correlate the biologic effects of 17-AAG and clinical response in patients with relapsed MCL, ALCL, and HL. [unreadable] [unreadable] [unreadable]..
- Evaluation of Stimulant DrugsSharon Wigal; Fiscal Year: 2006..Within-subject PK variability in time-course of serum concentration for each medication will be analyzed, and the time-response characteristics also will be estimated based on PD measures for methylphenidate. ..
- Quality Life Among Youth with Craniofacial ConditionsDonald Patrick; Fiscal Year: 2004..S., and one in the United Kingdom. Adolescents and their parents will complete questionnaires at baseline, and gain at 1-2 year clinical follow-up. ..
- Serotonin, Drug Use and MDMA Induced DeficitsFREDERICK MOELLER; Fiscal Year: 2005..Specific Aim 3: To determine whether neurobehavioral deficits seen in heavy MDMA users are related to serotonergic function as measured by a mCPP neuroendocrine challenge in these subjects. ..
- In Vitro Mechanisms of Ethanol Induced Neuronal Death.Steven Mennerick; Fiscal Year: 2005..The proposed experiments should lead to a better fundamental understanding of the mechanisms by which forebrain neurons are susceptible to ethanol-induced death. ..
- THERAPEUTIC STUDIES OF ANAPLASTIC GLIOMASLOUIS NABORS; Fiscal Year: 2008..This proposal thus builds on our extensive clinical investigative expertise within the context of a well-established multi-institutional brain tumor treatment consortium. ..
- X-Treme CT Equipment GrantJoel Finkelstein; Fiscal Year: 2007..We propose to use XtremeCT in a wide range of studies of bone disease that span a multitude of disciplines and serve a wide range of investigators in Boston and throughout New England. [unreadable] [unreadable] [unreadable]..
- COCAINE: A STUDY OF THE BIOCHEMICAL MECHANISM OF ACTIONFrank Carroll; Fiscal Year: 2007..abstract_text> ..
- Quality of Life of Overweight Youth: Multicultural ViewDonald Patrick; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- CHOLESTEROL REDUCTION EFFECTS ON BEHAVIORMatthew Muldoon; Fiscal Year: 2001..The use of two treatment intensities will permit examination of the dose-response relationship between the degree of cholesterol lowering and cognitive performance. ..
- Endpoint Analyses of Anti-Integrin Therapy for GliomasLOUIS NABORS; Fiscal Year: 2004..Data from these studies will be critically important in developing, refining and validating non-invasive methodologies for timely assessment of specific anti-angiogenic therapies for malignant brain tumors in patients. ..