- Biomechanics and biophysics of cancer cells
Department of Materials Science and Engineering, Division of Biological Engineering, and Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
Acta Biomater 3:413-38. 2007
..presents an overview of the rapidly expanding, nascent field of research that deals with the biomechanics and biophysics of cancer cells...
- Emerging issues of connexin channels: biophysics fills the gap
A L Harris
Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
Q Rev Biophys 34:325-472. 2001
..However, the relation between these two mechanisms are unexplored, as are specific mechanisms of direct endogenous regulation of connexin channel activity. (ABSTRACT TRUNCATED)..
- Protein stability imposes limits on organism complexity and speed of molecular evolution
Konstantin B Zeldovich
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 104:16152-7. 2007
- Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications
M C Pedroso de Lima
Department of Biochemistry, University of Coimbra, 3000 codex, Coimbra, Portugal
Adv Drug Deliv Rev 47:277-94. 2001
- Unusual biophysics of intrinsically disordered proteins
Vladimir N Uversky
Department of Molecular Medicine, University of South Florida, Tampa, FL, USA
Biochim Biophys Acta 1834:932-51. 2013
..All this requires a close attention to the peculiarities of biophysics of these proteins. In this review, some key biophysical features of IDPs are covered...
- Beyond bistability: biophysics and temporal dynamics of working memory
Centre for Theoretical and Computational Neuroscience, University of Plymouth, A 220 Portland Square, Drake Circus, Plymouth PL4 8AA, UK
Neuroscience 139:119-33. 2006
..Together such findings may lay the foundations for highly dynamical theories of working memory based on biophysical principles...
- Implications of synaptic biophysics for recurrent network dynamics and active memory
Central Institute of Mental Health, RG Computational Neuroscience, and Interdisciplinary Center for Neurosciences, University of Heidelberg, Mannheim, Germany
Neural Netw 22:1189-200. 2009
..In this sense, this article is a plead for taking the specific biophysics of real neurons and synapses seriously when trying to account for the neurobiology of cognition.
- Large-scale biophysics: ion flows and regeneration
Center for Regenerative and Developmental Biology, Forsyth Institute and Developmental Biology Department, Harvard School of Dental Medicine, Boston, MA 02115, USA
Trends Cell Biol 17:261-70. 2007
- The physics, biophysics and technology of photodynamic therapy
Brian C Wilson
Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Phys Med Biol 53:R61-109. 2008
..This paper reviews the current status of PDT with an emphasis on the contributions of physics, biophysics and technology, and the challenges remaining in the optimization and adoption of this treatment modality...
- Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein
Vladimir N Uversky
Institite for Intrinsically Disordered Protein Research, Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Curr Protein Pept Sci 10:483-99. 2009
..This review focuses on the contributions of Prof. Anthony L. Fink to the field and presents some recent developments in this exciting area...
- Structure and biophysics of type III secretion in bacteria
Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA
Biochemistry 52:2508-17. 2013
..This review will focus on the latest developments and future challenges concerning the structure and biophysics of the needle apparatus.
- A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee
Department of Neurology, Christian Albrechts University, Kiel, Germany
Clin Neurophysiol 123:858-82. 2012
..Additional sections cover safety issues, the triple stimulation technique, and neuropediatric aspects of TMS...
- A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy
Jeanne T Paz
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA
Nat Neurosci 14:1167-73. 2011
..This mode could be active under other circumstances, representing a previously unknown channel of cortico-thalamo-cortical information processing...
- Time-resolved methods in biophysics. 3. Fluorescence lifetime correlation spectroscopy
Institute for Biological Information Processing 1, Forschungszentrum Julich, D 52425, Julich, Germany
Photochem Photobiol Sci 6:13-8. 2007
..The theoretical basis of FLCS is explained, and the method is applied to the study of a dynamic transition between two fluorescence lifetime states in a dye-protein complex...
- Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells
Department of Neuroscience, Nanostructured Interfaces and Surfaces Centre of Excellence, Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, 10125 Torino, Italy
J Neurosci 30:491-504. 2010
..2, as subthreshold pacemaker channels in MCCs and open new interesting features about their role in the control of firing and catecholamine secretion at rest and during sustained stimulations matching acute stress...
- Distinct membrane mechanical properties of human mesenchymal stem cells determined using laser optical tweezers
Department of Bioengineering, University of Illinois, Chicago, Illinois 60607, USA
Biophys J 90:2582-91. 2006
..We postulate that whereas fibroblasts use both the membrane rigidity and membrane-cytoskeleton association to regulate their membrane reservoir, hMSC cytoskeleton has only a minor impact on stem cell membrane mechanics...
- Modulation of cellular mechanics during osteogenic differentiation of human mesenchymal stem cells
Department of Bioengineering, University of Illinois, Chicago, Illinois 60607, USA
Biophys J 93:3693-702. 2007
- Biophysics, physiological ecology, and climate change: does mechanism matter?
Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
Annu Rev Physiol 67:177-201. 2005
- Energetics of inclusion-induced bilayer deformations
Department of Physiology and Biophysics, Cornell University Medical College, New York, New York 10021, USA
Biophys J 74:1966-83. 1998
..3 A can increase the Boltzmann factor (the equilibrium distribution for protein conformation) 10-fold due to the elastic properties of the bilayer...
- Prediction of electroencephalographic spectra from neurophysiology
P A Robinson
School of Physics, University of Sydney, New South Wales 2006, Australia
Phys Rev E Stat Nonlin Soft Matter Phys 63:021903. 2001
..Three types of potential instability are found: one at zero frequency, another in the theta band at around half the alpha frequency, and a third at the alpha frequency itself...
- From biophysics to evolutionary genetics: statistical aspects of gene regulation
Institut fur Theoretische Physik, Universitat zu Koln, Zülpicher Str, 77, 50937 Koln, Germany
BMC Bioinformatics 8:S7. 2007
..We focus on the links between the biophysical function and the evolution of regulatory elements. In particular, we infer fitness landscapes of binding sites from genomic data, leading to a quantitative evolutionary picture of regulation...
- Hyperpolarization-activated graded persistent activity in the prefrontal cortex
Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
Proc Natl Acad Sci U S A 105:7298-303. 2008
- Missense meanderings in sequence space: a biophysical view of protein evolution
Mark A DePristo
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Nat Rev Genet 6:678-87. 2005
..Here we review the literature on biophysics as it relates to molecular evolution, focusing on how protein stability and aggregation affect organismal ..
- Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing
D I Svergun
European Molecular Biology Laboratory, Hamburg, Germany and Institute of Crystallography, Russian Academy of Sciences, Moscow, Russia
Biophys J 76:2879-86. 1999
..Application of the method is illustrated by the restoration of a ribosome-like model structure and more realistically by the determination of the shape of several proteins from experimental x-ray scattering data...
- Biophysics of α-synuclein membrane interactions
Candace M Pfefferkorn
Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Biochim Biophys Acta 1818:162-71. 2012
..Finally, we discuss biophysical evidence supporting a key role for membranes and α-syn in PD pathogenesis. This article is part of a Special Issue entitled: Membrane protein structure and function...
- Biophysics of microchannel-enabled neuron-electrode interfaces
Neuroengineering Group, Catalonia Bioengineering Institute IBEC, c Baldiri i Reixach 15 21, 08028 Barcelona, Spain
J Neural Eng 9:026010. 2012
..Despite the low degree of complexity involved in their fabrication and use, μChannel devices provide a single-unit mean SNR of 101 ± 76, which compares favourably with the SNR obtained from typical microelectrode arrays...
- A method to track rotational motion for use in single-molecule biophysics
Department of BioNanoScience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands
Rev Sci Instrum 82:103707. 2011
..In addition, we envision uses of the algorithm in a range of biophysical measurements, including further extensions of MT, tethered particle motion, and optical trapping measurements...
- Interlaced optical force-fluorescence measurements for single molecule biophysics
Ricardo R Brau
Department of Mechanical Engineering, Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, 02139, USA
Biophys J 91:1069-77. 2006
- Biophysics of malarial parasite exit from infected erythrocytes
Singapore MIT Alliance for Research and Technology Centre, Singapore, Singapore
PLoS ONE 6:e20869. 2011
..These findings provide a comprehensive, previously unavailable, body of information on the combined effects of biochemical and biophysical factors on parasite egress from iRBCs...
- Alternans resonance and propagation block during supernormal conduction in cardiac tissue with decreased [K(+)](o)
Enno de Lange
Department of Physiology, University of Bern, Bern, Switzerland
Biophys J 98:1129-38. 2010
..We conclude that supernormal conduction potentiates alternans and spatial analysis of IBIs represents a powerful method to locate tissue heterogeneities...
- Measuring the viscoelastic properties of human platelets with the atomic force microscope
Department of Physics, University of California, Santa Barbara 93106, USA
Biophys J 70:556-67. 1996
..The elastic moduli were in a range of 1-50 kPa measured in the frequency range of 1-50 Hz. Loading forces could be controlled with a resolution of 80 pN and indentations of the platelet could be determined with a resolution of 20 nm...
- Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design
Beijing Institute of Pharmacology and Toxicology, Haidian District, Beijing 100850, China
Curr Top Med Chem 11:2959-84. 2011
- Biophysics of magnetic orientation: strengthening the interface between theory and experimental design
Joseph L Kirschvink
Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA
J R Soc Interface 7:S179-91. 2010
- Thermo-TRP channels: biophysics of polymodal receptors
Facultad de Ciencias, Centro Interdisciplinario de Neurociencias de Valparaíso Universidad de Valparaíso, Valparaiso, Chile
Adv Exp Med Biol 704:469-90. 2011
..We conclude that the present data is most economically explained by allosteric models in which temperature, voltage, and agonists act separately to modulate channel activity...
- Cationic liposomes for gene delivery: from biophysics to biological applications
M C Pedroso de Lima
Department of Biochemistry and University of Coimbra, Coimbra, Portugal
Curr Med Chem 10:1221-31. 2003
- Untreatable pain resulting from abdominal cancer: new hope from biophysics?
Delta Research and Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy
JOP 4:1-10. 2003
..Visceral pain characterizing pancreatic cancer is the most difficult symptom of the disease to control and can significantly impair the quality of life which remains and increase the demand for euthanasia...
- Lessons from the biophysics of interfaces: lung surfactant and tear fluid
Antti H Rantamäki
Helsinki Eye Lab, Department of Ophthalmology, University of Helsinki, Helsinki, Finland
Prog Retin Eye Res 30:204-15. 2011
..The dynamics of this cycle have been studied to a lesser extent and are not as clear as those of lung surfactant. The common structure and properties suggest a similar behaviour under rapid compression-expansion for both fluids...
- Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release
Lyanne C Schlichter
Toronto Western Research Institute, University Health Network, Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Channels (Austin) 5:128-37. 2011
..Together, these results confirm the similarity of IClswell in the two cell types, and point to a role for this channel in inflammation-mediated glutamate release in the CNS...
- Dynamic causal modelling: a critical review of the biophysical and statistical foundations
Wellcome Trust Centre for Neuroimaging, University College of London, UK
Neuroimage 58:312-22. 2011
..Finally, we discuss potential extensions of the current DCM framework, such as stochastic DCMs, plastic DCMs and field DCMs...
- Compensation for variable intrinsic neuronal excitability by circuit-synaptic interactions
Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02454 9110, USA
J Neurosci 30:9145-56. 2010
..This work experimentally confirms results from previous modeling studies; tuning synaptic and intrinsic conductances can yield similar circuit outputs from neurons with variable intrinsic excitability...
- Propagator theory of brain dynamics
P A Robinson
School of Physics, University of Sydney, New South Wales, Australia
Phys Rev E Stat Nonlin Soft Matter Phys 72:011904. 2005
..This resonance involves feedback loops incorporating slow, short-range inhibitory fibers...
- Wavelength and vulnerability to atrial fibrillation: Insights from a computer model of human atria
Signal Processing Institute, Ecole Polytechnique Federale de Lausanne EPFL, Station 11, Switzerland
Europace 7:83-92. 2005
..To explain the contradictory results related to the concept of critical cardiac wavelength in the initiation and perpetuation of atrial fibrillation (AF)...
- Orientation discrimination of single-stranded DNA inside the alpha-hemolysin membrane channel
Rowland Institute, Harvard University, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 102:12377-82. 2005
..Our results imply that the translocation process through a narrow pore is more complicated than previously believed and involves base tilting and stretching of ssDNA molecules inside the confining pore...
- Electrophysiological analysis of the yeast V-type proton pump: variable coupling ratio and proton shunt
Botanisches Institut I, Universitat Karlsruhe, Karlsruhe, Germany
Biophys J 85:3730-8. 2003
- Maximum likelihood estimation of ion channel kinetics from macroscopic currents
Lorin S Milescu
Department of Physiology and Biophysics, State University of New York, Buffalo, New York, USA
Biophys J 88:2494-515. 2005
..Given appropriate stimulation protocols, our method chose a reasonable model size and topology...
- The application of statistical physics to evolutionary biology
Center for the Study of Rationality, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
Proc Natl Acad Sci U S A 102:9541-6. 2005
..Finally, just as the free energy function quantitatively characterizes the balance between energy and entropy, a free fitness function provides an analytical expression for the balance between natural selection and stochastic drift...
- Bursting activation of prefrontal cortex drives sustained up states in nucleus accumbens spiny neurons in vivo
Aaron J Gruber
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
Synapse 63:173-80. 2009
..Synapse 63:173-180, 2009. (c) 2008 Wiley-Liss, Inc...
- Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution
Chi Yuan Chou
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
Biophys J 88:455-66. 2005
..The structural variation of the N-terminal truncated apoE3 and apoE4 protein provides useful information that helps to explain the greater aggregation of the apoE4 isoform and thus has implication for the involvement of apoE4 in AD...
- Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation
Sandeep V Pandit
Institute for Cardiovascular Research and Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
Biophys J 88:3806-21. 2005
..Altering the rectification profile of I(K1) also slowed down or abolished reentrant activity. In combination, these simulation results provide novel insights into the ionic bases of a sustained rotor in a 2-D chronic AF substrate...
- Ultrasound-biophysics mechanisms
WILLIAM D O'BRIEN
Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois, 405 N Mathews, Urbana, IL 61801, USA
Prog Biophys Mol Biol 93:212-55. 2007
Ultrasonic biophysics is the study of mechanisms responsible for how ultrasound and biological materials interact. Ultrasound-induced bioeffect or risk studies focus on issues related to the effects of ultrasound on biological materials...
- A biophysically based neural model of matching law behavior: melioration by stochastic synapses
Volen Center for Complex Systems, Department of Physics, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 26:3731-44. 2006
- Time-resolved methods in Biophysics. 2. Monitoring haem proteins at work with nanosecond laser flash photolysis
Dipartimento di Fisica, Universita degli Studi di Parma, Parma, Italy
Photochem Photobiol Sci 5:1109-20. 2006
Haem proteins have long been the most studied proteins in biophysics, and have become paradigms for the characterization of fundamental biomolecular processes as ligand binding and regulatory conformational transitions...
- Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron
School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
J Neurophysiol 102:3673-88. 2009
..These data can now be used to investigate the roles of Shaker and Shal for motoneuron intrinsic properties, synaptic integration, and spiking output during behavior by targeted genetic manipulations...
- Low conductance gap junctions mediate specific electrical coupling in body-wall muscle cells of Caenorhabditis elegans
Department of Neuroscience, University of Connecticut Health Center, Connecticut 06030, USA
J Biol Chem 281:7881-9. 2006
..These analyses provide a relatively detailed description of innexin-based gap junctions in a native tissue and suggest that innexin-based small conductance gap junctions can play an important role in processes such as locomotion...
- Super-resolved FT-IR spectroscopy: Strategies, challenges, and opportunities for membrane biophysics
Jessica J Li
Department of Chemical Engineering and Applied Chemistry, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada M5S 3E1
Biochim Biophys Acta 1828:2272-82. 2013
..The challenges and opportunities that these platforms present for examining dynamic phenomena will be discussed. This article is part of a Special Issue entitled: FTIR in membrane proteins and peptide studies. ..
- The use of pHluorins for optical measurements of presynaptic activity
Department of Biochemistry, The Weill Medical College of Cornell University, New York, New York 10021, USA
Biophys J 79:2199-208. 2000
..A theoretical analysis of the expected signals using this approach and guidelines for future reporter development are provided...
- Mechanism of gain modulation at single neuron and network levels
Division of Biology, Mail code 216 76, California Institute of Technology, Pasadena, CA 91125, USA
J Comput Neurosci 25:158-68. 2008
- Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Biophys J 68:988-96. 1995
..These results indicate that the actin cytoskeleton affects the membrane mechanical properties, including the force required for membrane extension and the viscoelastic behavior...
- On the biophysics of cathodal galvanotaxis in rat prostate cancer cells: Poisson-Nernst-Planck equation approach
Department of Physical Chemistry and Technology of Polymers, Section of Physics and Applied Mathematics, Silesian University of Technology, 44 100 Ks M Strzody 9, Gliwice, Poland
Eur Biophys J 41:527-34. 2012
..The disturbance in the calcium distribution may then drive actin polymerization and myosin contraction. The presented modeling is done within a continuous one-dimensional Poisson-Nernst-Planck equation framework...
- Advances in magnetic tweezers for single molecule and cell biophysics
UCD Nanomedicine Centre, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
Integr Biol (Camb) 6:27-34. 2014
..We review recent MTW studies in single molecule and cell biophysics that demonstrate the flexibility of this technique...
- Cellular biophysics: bacterial endospore, membranes and random fluctuation
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1855, USA
Curr Biol 16:R1025-8. 2006
- Single-molecule biophysics: at the interface of biology, physics and chemistry
Ashok A Deniz
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J R Soc Interface 5:15-45. 2008
..This review presents an overview of the burgeoning field of single-molecule biophysics, discussing key highlights and selected examples from its genesis to our projections for its future...
- Doing molecular biophysics: finding, naming, and picturing signal within complexity
Jane S Richardson
Department of Biochemistry, Duke University, Durham, North Carolina 27710, USA
Annu Rev Biophys 42:1-28. 2013
..Here we relate parts of our scientific and personal lives, including ups and downs, influences, anecdotes, and guiding principles such as the title theme...
- Manipulating forces between surfaces: applications in colloid science and biophysics
Paul F Luckham
Department Chemical Engineering and Chemical Technology, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BY, UK
Adv Colloid Interface Sci 111:29-47. 2004
- Biophysics. Enigmas of blood clot elasticity
John W Weisel
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Science 320:456-7. 2008
- Virtual radiation biophysics: implications of nuclear structure
Kirchhoff Institute for Physics, INF 227 Heidelberg, Germany
Cytogenet Genome Res 104:157-61. 2004
..Regarding one-chromosome yields, remarkable differences for single CTs were observed taking into account the gene density-correlated distribution of CTs...
- Time-resolved methods in biophysics. 10. Time-resolved FT-IR difference spectroscopy and the application to membrane proteins
Bielefeld University, Department of Chemistry, Biophysical Chemistry, 33615, Bielefeld, Germany
Photochem Photobiol Sci 8:1517-28. 2009
..Examples of applications to retinal proteins and energy transduction complexes are reviewed, which emphasize the impact of time-resolved FT-IR spectroscopy on the understanding of protein reactions on the level of single bonds...
- Dynamics of human atrial cell models: restitution, memory, and intracellular calcium dynamics in single cells
Elizabeth M Cherry
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Prog Biophys Mol Biol 98:24-37. 2008
- Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
Eur J Pharmacol 589:272-80. 2008
..In addition we performed a biophysics experiment by quasi elastic neutron scattering (QENS) study, to investigate whether the membrane stability ..
- Biophysics and dynamics of natural and engineered stem cell microenvironments
Albert J Keung
Department of Chemical Engineering, University of California, Berkeley, CA, USA
Wiley Interdiscip Rev Syst Biol Med 2:49-64. 2010
- The light-induced reduction of horizontal cell receptive field size in the goldfish retina involves nitric oxide
Bryan A Daniels
Department of Anatomy and Neurobiology, Laboratory for Retina and Optic Nerve Research, Dalhousie University, Halifax, Nova Scotia, Canada
Vis Neurosci 28:137-44. 2011
..These findings suggest that nitric oxide is involved in light-induced reduction of horizontal cell receptive field size...
- Biology and biophysics of the nuclear pore complex and its components
Roderick Y H Lim
M E Müller Institute for Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Int Rev Cell Mol Biol 267:299-342. 2008
- Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure
Australian Centre for Vaccine Development, Tumour Immunology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
Am J Transplant 12:15-26. 2012
- Multiple events on single molecules: unbiased estimation in single-molecule biophysics
Daniel A Koster
Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
Proc Natl Acad Sci U S A 103:1750-5. 2006
..We demonstrate the potential of the method for a number of single-molecule experiments, focusing on the removal of DNA supercoils by topoisomerase IB, and validate the method by numerical simulation of the experiment...
- Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets
Krasnow Institute for Advanced Study, George Mason University, 4400 University Drive, MS 2A1, Fairfax, Virginia 22030 4444, USA
Curr Med Chem 15:2456-71. 2008
- From autopoiesis to neurophenomenology: Francisco Varela's exploration of the biophysics of being
Laboratoire de Neurosciences Cognitives et Imagerie Cerebrale, CNRS UPR 640, Hopital de la Pitie Salpetriere, 47 bd de l Hopital, 75651, Paris, France
Biol Res 36:27-65. 2003
..Finally, we discuss Varela's essential contribution to our understanding of the generation of consciousness in the framework of what we call his "biophysics of being."
- Unifying constructal theory for scale effects in running, swimming and flying
Duke University, Department of Mechanical Engineering and Materials Science, Durham, NC 27708 0300, USA
J Exp Biol 209:238-48. 2006
..This theory, and the general body of work known as constructal theory, together now show that animal movement (running, flying, swimming) and fluid eddy movement (turbulent structure) are both forms of optimized intermittent movement...
- The biophysics of asthmatic airway smooth muscle
Newman L Stephens
Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Ave, Winnipeg, MB, Canada R3E 3J7
Respir Physiol Neurobiol 137:125-40. 2003
..Measurements also indicate that increased smooth muscle myosin light chain kinase content, via increased actomyosin ATPase activity could be responsible for the changes in contractility...
- Biophysics and clinical utility of irrigated-tip radiofrequency catheter ablation
Section of Electrophysiology, Division of Cardiovascular Medicine, Ross Heart Hospital, The Ohio State University, Columbus, USA
Expert Rev Med Devices 9:59-70. 2012
..The purpose of this article is to review cooled-tip RF ablation biophysics and outcomes of clinical studies as well as to discuss future technological improvements.
- Time-resolved methods in biophysics. 7. Photon counting vs. analog time-resolved singlet oxygen phosphorescence detection
Grup d Enginyeria Molecular, Institut Quimic de Sarria, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain
Photochem Photobiol Sci 7:1003-10. 2008
..Principles underlying this novel approach and selected examples of applications are provided in this perspective, which illustrate the advantages over the conventional analog detection mode...
- Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:16116-21. 2007
..The results may also provide some insights into the nature of the energy landscape in the vicinity of the folded protein free energy minimum...
- A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
J Biol Chem 282:35133-42. 2007
..8 mM Ca(2+) external solutions. This is the first time that a smooth muscle Ca(v)1.2 splice variant has been identified functionally to possess biophysical property that can be linked to enhanced state-dependent block by DHP...
- Role of glutamate autoreceptors at hippocampal mossy fiber synapses
Hyung Bae Kwon
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neuron 60:1082-94. 2008
..Thus, negative feedback via presynaptic mGluRs is the dominant mode of glutamatergic autoregulation at the mf-CA3 synapse...
- From biophysics to cognition: reward-dependent adaptive choice behavior
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Curr Opin Neurobiol 18:209-16. 2008
..This review focuses on recent studies of reward-based decision-making that have begun to tackle this challenge...
- Phase diagrams of quasispecies theory with recombination and horizontal gene transfer
J M Park
Department of Physics and Astronomy and Department of Bioengineering, Rice University, Houston, Texas 77005 1892, USA
Phys Rev Lett 98:058101. 2007
..We show how transfer of genetic information changes the phase diagram and mean fitness and introduces metastability in quasispecies theory, via an analytic field theoretic mapping...
- Foreword: lipid rafts/biophysics, cell signalling, trafficking and processing
Nigel M Hooper
Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, UK
Mol Membr Biol 23:1-3. 2006
- Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1
Department of Behavioral Neuroscience and Neuroscience Graduate Program, Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Neurosci 29:563-74. 2009
..GluR5-containing KARs on interneurons in stratum oriens do not contribute substantially to the EPSC. We conclude that KARs are localized to synapses by cell type-, synapse-, and subunit-selective mechanisms...
- From biophysics to behavior: Catacomb2 and the design of biologically-plausible models for spatial navigation
Robert C Cannon
Theoretical Neurobiology, Born Bunge Foundation, University of Antwerp, Universiteitsplein I, Antwerp, Belgium
Neuroinformatics 1:3-42. 2003
- Functional consequences of animal-to-animal variation in circuit parameters
Jean Marc Goaillard
Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts, USA
Nat Neurosci 12:1424-30. 2009
..These data illustrate the importance of making multidimensional measurements from single preparations for understanding how variability in circuit output is related to the variability of multiple circuit parameters...
- The Bax pore in liposomes, Biophysics
P H Schlesinger
Department of Physiology and Cell Biology, Washington University School of Medicine, St Louis, MO 63110, USA
Cell Death Differ 13:1403-8. 2006
..Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers...
- Functional properties of the surface of the vermilion border of the lips are distinct from those of the facial skin
Department of Dermatology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aobaku, Sendai 980 8574, Japan
Br J Dermatol 150:563-7. 2004
..Despite its prominent presence on the face, constituting not only the target of cosmetics but also the site for various skin diseases, its functional properties remain almost unknown...
- Physical constraints and functional characteristics of transcription factor-DNA interaction
Department of Physics, University of California at San Diego, La Jolla, CA 92093 0319, USA
Proc Natl Acad Sci U S A 99:12015-20. 2002
..We suggest further experiments to test whether this is a general feature for a large class of TFs...
- Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site
Laval Hospital, Research Center, Ste Foy, Quebec, G1V 4G5 Canada
Biophys J 75:236-46. 1998
..3-fold increase in affinity). Furthermore, substitution at Asp730 with cysteine and exposure to Cd2+ or methanethiosulfonate reagents had no significant effect on sodium currents, consistent with this residue not contributing to the pore...
- Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects
Departments of Physiology and Surgery, Faculty of Medicine, University of Manitoba, Manitoba, Winnipeg R3E 3J7, Canada
Am J Physiol Lung Cell Mol Physiol 283:L1181-9. 2002
..04 +/- 0.008, n = 11; P < 0.05). Messages for myosin heavy chain isoforms showed no difference. Increased kinase message content is an index of the mechanism for the increased velocity and capacity of shortening we report...
- Biophysics of nonablative dermal remodeling
E Victor Ross
Dermatology Department, Naval Medical Center San Diego, San Diego, CA 92134, USA
Semin Cutan Med Surg 21:251-65. 2002
..The article is divided into a discussion of the physics of laser-tissue interactions, followed by a review of the types of devices used for nonablative skin remodeling, and the histologic findings that follow treatment...
- A mechanistic model of the actin cycle
Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA
Biophys J 86:2720-39. 2004
..This limitation arises because as the cycle becomes more dynamic, it tends toward the unpolymerized state...
- A novel extended Granger Causal Model approach demonstrates brain hemispheric differences during face recognition learning
Centre for Computational Systems Biology, Fudan University, Shanghai, People s Republic of China
PLoS Comput Biol 5:e1000570. 2009
..The results provide the first evidence for connectivity changes between and within left and right inferotemporal cortexes as a result of face recognition learning...
- Biophysics of cardiopulmonary resuscitation with periodic z-axis acceleration or abdominal compression at aortic resonant frequencies
Charles F Babbs
Department of Basic Medical Sciences, Purdue University, 1426 Lynn Hall, West Lafayette, IN 47907 1246, USA
Resuscitation 69:455-69. 2006
..The method is able to sustain blood flow and long-term survival during and after prolonged cardiac arrest in anesthetized pigs. However, the exact mechanism by which circulation of blood is created has remained unknown...
- Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water
Department of Biological Sciences, Faculty of Science, Yong Loo Lin School of Mediciine, National Univeristy of Singapore, Singapore
Biophys J 91:4201-9. 2006
..Our discovery not only gives a novel insight into the properties of insoluble proteins, but also sheds the first light that we know of on previously unknown regimes associated with proteins...
- Molecular structure of amyloid fibrils: insights from solid-state NMR
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0520, USA
Q Rev Biophys 39:1-55. 2006
- Mechanics, malignancy, and metastasis: the force journey of a tumor cell
Department of Bioengineering, University of California, Berkeley, USA
Cancer Metastasis Rev 28:113-27. 2009