gluconeogenesis

Summary

Summary: Biosynthesis of GLUCOSE from nonhexose or non-carbohydrate precursors, such as LACTATE; PYRUVATE; ALANINE; and GLYCEROL.

Top Publications

  1. ncbi Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis
    W Becker
    Institute of Pharmacology and Toxicology, Medical Faculty of Aachen University, Wendlingweg 2, D 52074 Aachen, Germany
    J Mol Endocrinol 32:195-208. 2004
  2. pmc Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 120:2355-69. 2010
  3. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
  4. ncbi Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    J C Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 413:131-8. 2001
  5. pmc Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
    Maria M Mihaylova
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 145:607-21. 2011
  6. ncbi The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    Seung Hoi Koo
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, California 92037 1002, USA
    Nature 437:1109-11. 2005
  7. pmc Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
    Wenqing Jiang
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Medical College, Fudan University, Shanghai 20032, China
    Mol Cell 43:33-44. 2011
  8. pmc Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
    Eric E Zhang
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, USA
    Nat Med 16:1152-6. 2010
  9. pmc BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
    R Daniel Rudic
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Biol 2:e377. 2004
  10. pmc Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    Shijie Li
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 107:3441-6. 2010

Research Grants

  1. HYPOGLYCEMIC ACTION OF 2-CHLOROPROPIONATE
    Robert Harris; Fiscal Year: 1980
  2. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1993
  3. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1991
  4. GLUCONEOGENESIS & DE NOVO LIPOGENESIS IN CYSTIC FIBROSIS
    DANA HARDIN; Fiscal Year: 2000
  5. ALTERNATIVE ROLES FOR PHOSPHOENOLPYRUVATE CARBOXYKINASE
    Paul Ray; Fiscal Year: 1991
  6. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
  7. HORMONAL CONTROL OF HEPATIC GLUCONEOGENESIS/GLYCOLYSIS
    Alex Lange; Fiscal Year: 2005
  8. ENERGY HOMEOSTASIS BY SPECIFIC ORGANS IN SHOCK
    Frederick Pearce; Fiscal Year: 1992
  9. CONTROL MECHANISMS OF HEPATIC GLUCOSE OUTPUT
    John Clore; Fiscal Year: 2000

Detail Information

Publications274 found, 100 shown here

  1. ncbi Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis
    W Becker
    Institute of Pharmacology and Toxicology, Medical Faculty of Aachen University, Wendlingweg 2, D 52074 Aachen, Germany
    J Mol Endocrinol 32:195-208. 2004
    ....
  2. pmc Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 120:2355-69. 2010
    ..protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic gluconeogenesis. However, the molecular mechanism by which this pathway operates had remained elusive...
  3. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha. These findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan...
  4. ncbi Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    J C Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 413:131-8. 2001
    ..b>Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus...
  5. pmc Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
    Maria M Mihaylova
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 145:607-21. 2011
    ..Finally, suppression of class IIa HDACs in mouse models of type 2 diabetes ameliorates hyperglycemia, suggesting that inhibitors of class I/II HDACs may be potential therapeutics for metabolic syndrome...
  6. ncbi The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    Seung Hoi Koo
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, California 92037 1002, USA
    Nature 437:1109-11. 2005
    ..When cellular ATP levels are low, however, the energy-sensing kinase AMPK inhibits hepatic gluconeogenesis through an unknown mechanism...
  7. pmc Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
    Wenqing Jiang
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Medical College, Fudan University, Shanghai 20032, China
    Mol Cell 43:33-44. 2011
    ..is irreversible, and the reverse reaction requires phosphoenolpyruvate carboxykinase (PEPCK1) to commit for gluconeogenesis. Here, we show that acetylation regulates the stability of the gluconeogenic rate-limiting enzyme PEPCK1, ..
  8. pmc Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
    Eric E Zhang
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, USA
    Nat Med 16:1152-6. 2010
    During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated ..
  9. pmc BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
    R Daniel Rudic
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Biol 2:e377. 2004
    ..b>Gluconeogenesis is abolished by deletion of Bmal1 and is depressed in Clock mutants, but the counterregulatory response of ..
  10. pmc Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    Shijie Li
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 107:3441-6. 2010
    ..e., it fails to suppress PEPCK and other genes of gluconeogenesis), yet it retains its ability to stimulate fatty acid synthesis (i.e...
  11. pmc The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
    Yiguo Wang
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 460:534-7. 2009
    In fasted mammals, circulating pancreatic glucagon stimulates hepatic gluconeogenesis in part through the CREB regulated transcription coactivator 2 (CRTC2, also referred to as TORC2)...
  12. pmc Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
    Jonathan German
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, Washington 98195
    Endocrinology 150:4502-11. 2009
    ..We conclude that hypothalamic leptin action increases peripheral insulin sensitivity primarily via effects on the liver and that the mechanism underlying this effect is dependent on the hepatic branch of the vagus nerve...
  13. pmc AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner
    Ji Min Lee
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 285:32182-91. 2010
    ..In conclusion, our results suggest that a delayed effect of metformin-mediated induction of SHP gene expression inhibits CREB-dependent hepatic gluconeogenesis.
  14. ncbi Gluconeogenesis in dairy cows: the secret of making sweet milk from sour dough
    Jörg R Aschenbach
    Department of Veterinary Medicine, Institute of Veterinary Physiology, Free University of Berlin, Berlin, Germany
    IUBMB Life 62:869-77. 2010
    b>Gluconeogenesis is a crucial process to support glucose homeostasis when nutritional supply with glucose is insufficient...
  15. ncbi Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus
    A Wajngot
    Department of Endocrinology and Diabetology, Karolinska Hospital, Stockholm, Sweden
    Metabolism 50:47-52. 2001
    Contributions of gluconeogenesis to glucose production were determined between 14 to 22 hours into a fast in type 2 diabetics (n = 9) and age-weight-matched controls (n = 7); ages, 60.4 +/- 2.3 versus 55.6 +/- 1...
  16. ncbi Expression profiling of cassava storage roots reveals an active process of glycolysis/gluconeogenesis
    Jun Yang
    Shanghai Center for Cassava Biotechnology, National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200032, China
    J Integr Plant Biol 53:193-211. 2011
    ..Among 25 significantly changed pathways identified, glycolysis/gluconeogenesis was the most evident one...
  17. pmc Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:4012-7. 2003
    ..coactivator-1alpha (PGC-1alpha) is induced in fasted or diabetic liver and activates the entire program of gluconeogenesis. PGC-1alpha interacts with several nuclear receptors known to bind gluconeogenic promoters including the ..
  18. ncbi Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..that regulates several metabolic processes, including mitochondrial biogenesis and respiration, hepatic gluconeogenesis, and muscle fiber-type switching...
  19. pmc Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis
    Yu yi Lin
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 136:1073-84. 2009
    ..Our findings demonstrate a regulatory function for the NuA4 complex in glucose metabolism and life span by acetylating a critical metabolic enzyme...
  20. pmc Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis
    Hong Liu
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Mol Microbiol 78:1038-54. 2010
    ..A. fumigatus AcuM also regulated genes involved in gluconeogenesis, and the ΔacuM mutant had impaired growth on gluconeogenic carbon sources...
  21. pmc Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    Nishanth E Sunny
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 14:804-10. 2011
    ..Individuals with NAFLD had 50% higher rates of lipolysis and 30% higher rates of gluconeogenesis. There was a positive correlation between IHTG content and both mitochondrial oxidative and anaplerotic ..
  22. ncbi Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    Pere Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 423:550-5. 2003
    Hepatic gluconeogenesis is absolutely required for survival during prolonged fasting or starvation, but is inappropriately activated in diabetes mellitus. Glucocorticoids and glucagon have strong gluconeogenic actions on the liver...
  23. pmc Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
    Bo Wang
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, OH 43210, USA
    Hepatology 56:186-97. 2012
    ..G6PC expression also correlated with tumor grade in human primary HCCs. Finally, this study showed that the activation of interleukin (IL)-6-Stat3 signaling caused the up-regulation of miR-23a expression in HCC...
  24. ncbi Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response
    Tatiane C Nogueira
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508 900, Brazil
    Endocrinology 152:1253-63. 2011
    ..the circadian rhythm in hepatic phosphoenolpyruvate carboxykinase expression (a limiting catalytic step of gluconeogenesis) and hepatic glucose production is maintained by both daily oscillation in autonomic inputs to the liver and ..
  25. pmc Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation
    Kumi Kimura
    Frontier Science Organization, Kanazawa University, Kanazawa, Ishikawa, Japan
    Diabetes 61:61-73. 2012
    ....
  26. ncbi Chitosan reduces gluconeogenesis and increases glucose uptake in skeletal muscle in streptozotocin-induced diabetic rats
    Shing Hwa Liu
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    J Agric Food Chem 58:5795-800. 2010
    ..The increased gluconeogenesis-related signals including phosphoenolpyruvate carboxykinase (PEPCK) expression and phosphorylations of p38 ..
  27. pmc Transcriptional response of Candida albicans upon internalization by macrophages
    Michael C Lorenz
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Eukaryot Cell 3:1076-87. 2004
    ....
  28. pmc Niche-specific regulation of central metabolic pathways in a fungal pathogen
    Caroline J Barelle
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cell Microbiol 8:961-71. 2006
    ..six-carbon compounds via the glycolytic pathway, and two-carbon compounds via the glyoxylate cycle and gluconeogenesis. We address a paradox regarding the roles of these central metabolic pathways in C...
  29. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..The pathways act synergistically to induce gluconeogenesis (glucose synthesis), although the underlying mechanism has not been determined...
  30. ncbi Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH
    Min Woo Lee
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Jangan gu, Suwon, Gyeonggi do 440 746, Korea
    Cell Metab 11:331-9. 2010
    ..Here, we report a critical function of ER-bound transcription factor, CREBH, in the regulation of hepatic gluconeogenesis. Expression of CREBH is markedly induced by fasting or in the insulin-resistant state in rodents in a ..
  31. pmc Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
    Ling He
    Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell 137:635-46. 2009
    ..Our findings point to CBP phosphorylation at Ser436 by metformin as critical for its therapeutic effect, and as a potential target for pharmaceutical intervention...
  32. ncbi Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2
    Takashi Okamoto
    First Institute of New Drug Discovery, Otsuka Pharmaceutical Co Ltd, Kawauchi cho, Tokushima, Japan
    Arch Biochem Biophys 491:46-52. 2009
    ..In this study, we attempted to establish a new method to evaluate gluconeogenesis using rat H4IIE hepatoma cells...
  33. pmc Genome-wide analysis of FoxO1 binding in hepatic chromatin: potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Nucleic Acids Res 40:11499-509. 2012
    ..As Pck1 and Pdk4 are downstream targets of retinoid signaling, these results suggest that FoxO1 plays a potential role in linking retinoid metabolism to hepatic gluconeogenesis.
  34. pmc Activation of K(ATP) channels suppresses glucose production in humans
    Preeti Kishore
    Albert Einstein College of Medicine, New York, New York, USA
    J Clin Invest 121:4916-20. 2011
    ..These results suggest that activation of hypothalamic K(ATP) channels may be an important regulator of EGP in humans and that this pathway could be a target for treatment of hyperglycemia in type 2 diabetes mellitus...
  35. ncbi Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta
    Cullen M Taniguchi
    Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 3:343-53. 2006
    ....
  36. ncbi Saccharomyces cerevisiae engineered for xylose metabolism requires gluconeogenesis and the oxidative branch of the pentose phosphate pathway for aerobic xylose assimilation
    Ronald E Hector
    Bioenergy Research Unit, National Center for Agricultural Utilization Research, Peoria, IL 61604, USA
    Yeast 28:645-60. 2011
    ..we investigated the possible reasons for this imbalance by deleting genes required for NADPH production and gluconeogenesis in S. cerevisiae. S...
  37. pmc Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
    Yiguo Wang
    Salk Institute for Biological Studies, Peptide Biology Laboratory, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:3087-92. 2010
    ..Our results suggest that small molecules that attenuate the CREB-CRTC2 pathway may provide therapeutic benefit to individuals with type 2 diabetes...
  38. ncbi Gluconeogenesis in the fetus and neonate
    S Kalhan
    Department of Pediatrics, Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    Semin Perinatol 24:94-106. 2000
    b>Gluconeogenesis (GNG), a key metabolic process, involves the formation of glucose and glycogen from non-glucose precursors via pyruvate...
  39. pmc STAT3 inhibition of gluconeogenesis is downregulated by SirT1
    Yongzhan Nie
    Nat Cell Biol 11:492-500. 2009
    The fasting-activated longevity protein sirtuin 1 (SirT1, ref. 1) promotes gluconeogenesis in part, by increasing transcription of the key gluconeogenic genes pepck1 and g6pase, through deacetylating PGC-1alpha and FOXO1 (ref. 4)...
  40. pmc Hypothalamic leucine metabolism regulates liver glucose production
    Ya Su
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 61:85-93. 2012
    ..We postulate that the metabolic sensing of leucine in the MBH is a previously unrecognized mechanism for the regulation of hepatic glucose production required to maintain glucose homeostasis...
  41. ncbi Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis
    Young Sun Lee
    Rosalind Franklin Comprehensive Diabetes Center, Department of Pathology, Chicago Medical School, North Chicago, IL 60064, USA
    Diabetes 56:1671-9. 2007
    ..these results show that a single administration of rAd-GLP-1 results in the long-term remission of diabetes in ob/ob mice by improving insulin sensitivity through restoration of insulin signaling and reducing hepatic gluconeogenesis.
  42. ncbi Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus
    Patricia Pennisi
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Betheda, MD 20892, USA
    Endocrinology 147:2619-30. 2006
    ..together these results demonstrate that the improvement of the hyperglycemia was achieved by inhibition of gluconeogenesis rather than an improvement in insulin sensitivity...
  43. pmc Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 106:12121-6. 2009
    Fasting hyperglycemia in patients with type 2 diabetes mellitus (T2DM) is attributed to increased hepatic gluconeogenesis, which has been ascribed to increased transcriptional expression of phosphoenolpyruvate carboxykinase (PEPCK) and ..
  44. ncbi Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, Toyama 930 0194, Japan
    Endocrinology 151:2040-9. 2010
    ..These results indicate that inhibition of mineralocorticoid receptor might be a beneficial therapeutic approach for diet-induced phenotypes of metabolic syndrome and fatty liver...
  45. pmc Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy
    Robert A Rizza
    Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Diabetes 59:2697-707. 2010
    ..Increased rates of gluconeogenesis and perhaps glycogenolysis contribute to hepatic insulin resistance...
  46. ncbi Metabolic effects of visceral fat accumulation in type 2 diabetes
    Amalia Gastaldelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Via Savi, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 87:5098-103. 2002
    ..euglycemic insulin clamp), 4) endogenous glucose output ([(3)H]glucose infusion technique), and 5) gluconeogenesis ((2)H(2)O method)...
  47. pmc Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation
    S P Burns
    Cellular Mechanisms Research Group, Medical Unit, St Bartholomew s and The Royal London Hospital School of Medicine and Dentistry, London, United Kingdom
    J Clin Invest 100:1768-74. 1997
    ..Fetal programming of adult glucose metabolism may operate partly through structural alterations and changes in glucokinase expression in the immediate perivenous region...
  48. ncbi Regulation of glucose production by the liver
    R C Nordlie
    Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58202, USA
    Annu Rev Nutr 19:379-406. 1999
    ..the uptake and storage of glucose via glycogenesis and the release of glucose via glycogenolysis and gluconeogenesis. The several substrate cycles in the major metabolic pathways of the liver play key roles in the regulation ..
  49. ncbi Hypothalamic K(ATP) channels control hepatic glucose production
    Alessandro Pocai
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 434:1026-31. 2005
    ..Hyperglycaemia is a hallmark of diabetes and is largely due to increased hepatic gluconeogenesis. The medial hypothalamus is a major integrator of nutritional and hormonal signals, which play pivotal roles ..
  50. ncbi Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis
    Marie E Beckner
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Lab Invest 85:1457-70. 2005
    ..The ability of astrocytic cells to remove lactate, the inhibitor of glycolysis, via gluconeogenesis and incorporation into glycogen led to consideration of supportive genetic mutations...
  51. ncbi Adult rats prenatally exposed to ethanol have increased gluconeogenesis and impaired insulin response of hepatic gluconeogenic genes
    Xing Hai Yao
    Diabetes Research Group, Univ of Manitoba, 715 McDermot Ave Rm 834, Winnipeg, Manitoba, Canada R3E 3P4
    J Appl Physiol 100:642-8. 2006
    ..to ethanol (EtOH rats) during pregnancy are insulin resistant, but it is unknown whether they have increased gluconeogenesis. To address this issue, we determined blood glucose and liver gluconeogenic genes, proteins, and enzyme ..
  52. pmc Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes
    Dipanjan Chanda
    National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 286:27971-9. 2011
    ..factor CREBH is emerging as a critical player in various hepatic metabolic pathways and regulates hepatic gluconeogenesis in diet-induced obese settings...
  53. pmc Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis
    Xuan Xia
    Department of Endocrinology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e16556. 2011
    ..The data suggest that BBR improves fasting blood glucose by direct inhibition of gluconeogenesis in liver. This activity is not dependent on insulin action...
  54. ncbi Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum
    Kensuke Yasui
    Health Care Research Center, Nisshin Pharma Inc, Fujimino, Saitama 356 8511
    Biomed Res 32:313-20. 2011
    ..In the present study, we examined the effects of intragastrical administration of EGCG on the expression of gluconeogenesis-related genes in the mouse intestine...
  55. ncbi Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis
    Sarawut Jitrapakdee
    Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Int J Biochem Cell Biol 44:33-45. 2012
    Hepatic gluconeogenesis is a major pathway that maintains normal plasma glucose levels during prolonged starvation...
  56. pmc Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon
    Elodie Mutel
    Institut National de la Sante et de la Recherche Medicale, U855, Lyon, France
    Diabetes 60:3121-31. 2011
    ..The aim of this study was to better define the importance of the three gluconeogenic organs in glucose homeostasis...
  57. pmc Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle
    Stephanie R Thorn
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    Endocrinology 150:3021-30. 2009
    ....
  58. pmc Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice
    Sabina Jelen
    From the Water and Salt Research Center, Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle, DK 8000 Aarhus C, Denmark
    J Biol Chem 286:44319-25. 2011
    ..Our experiments establish AQP9 as the primary route of hepatocyte glycerol uptake for gluconeogenesis and thereby explain the previously observed, alleviated diabetes in leptin receptor-deficient AQP9(-/-) mice.
  59. pmc Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
    Marciane Milanski
    Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil
    Diabetes 61:1455-62. 2012
    Defective liver gluconeogenesis is the main mechanism leading to fasting hyperglycemia in type 2 diabetes, and, in concert with steatosis, it is the hallmark of hepatic insulin resistance...
  60. pmc Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism
    Florian W Kiefer
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Endocrinology 153:3089-99. 2012
    ..WT livers. In vitro, retinoid or cAMP agonist stimulation markedly induced gluconeogenesis in WT but not Aldh1a1-deficient primary hepatocytes...
  61. ncbi Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis
    Masako Doi
    Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc, Naruto, Tokushima 772 8601, Japan
    Am J Physiol Endocrinol Metab 292:E1683-93. 2007
    ..This study evaluated the effect of isoleucine on glucose uptake and oxidation in fasted rats and on gluconeogenesis in vivo and in vitro...
  62. ncbi Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect
    Robert K Hall
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 707 Light Hall, Nashville, Tennessee 37232 0615, USA
    Mol Endocrinol 21:550-63. 2007
    Insulin represses gluconeogenesis, in part, by inhibiting the transcription of genes that encode rate-determining enzymes, such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase)...
  63. ncbi The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver
    Hiroshi Oiso
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 404:166-72. 2011
    Hepatic gluconeogenesis is crucial for glucose homeostasis. Although sirtuin 1 (Sirt1) is implicated in the regulation of gluconeogenesis in the liver, the effects of other histone deacetylases (HDAC) on gluconeogenesis are unclear...
  64. pmc Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
    Natasha Hausler
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Biochem J 394:465-73. 2006
    ..When lactate and pyruvate were eliminated from the perfusion medium, both gluconeogenesis and tricarboxylic-acid-cycle flux were dramatically lower...
  65. ncbi Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
    Paul W Caton
    Bart s and The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London, UK
    J Endocrinol 205:97-106. 2010
    Abnormal elevation of hepatic gluconeogenesis is central to the onset of hyperglycaemia in patients with type 2 diabetes mellitus (T2DM)...
  66. ncbi Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme
    Rafael F Say
    Mikrobiologie, Fakultat Biologie, Universitat Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Nature 464:1077-81. 2010
    ..autotrophic organisms use diverse carbon dioxide fixation mechanisms generating acetyl-coenzyme A, from which gluconeogenesis must start...
  67. ncbi Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases cAMP-stimulated hepatic gluconeogenesis via inhibition of CREB
    Hye Young Seo
    Department of Internal Medicine, Keimyung University School of Medicine, 194 Dongsan dong, Jung Gu, Daegu, 700 712, South Korea
    Endocrinology 151:561-8. 2010
    ..However, the direct effect of ER stress on hepatic gluconeogenesis is still not clear...
  68. ncbi Fructose-induced hypothalamic AMPK activation stimulates hepatic PEPCK and gluconeogenesis due to increased corticosterone levels
    Andrezza Kinote
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Alexander Fleming Street, 101, 13084 971Campinas SP, Brazil
    Endocrinology 153:3633-45. 2012
    Fructose consumption causes insulin resistance and favors hepatic gluconeogenesis through mechanisms that are not completely understood...
  69. ncbi Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats
    Assaad Eid
    Laboratoire de Physiopathologie Métabolique et Rénale, INSERM UMR 499, Faculté de Médecine R T H Laënnec, Rue G Paradin, 69372 Lyon Cedex 08, France
    J Am Soc Nephrol 17:398-405. 2006
    Recent studies indicate that renal gluconeogenesis is substantially stimulated in patients with type 2 diabetes, but the mechanism that is responsible for such stimulation remains unknown...
  70. ncbi The quantification of gluconeogenesis in healthy men by (2)H2O and [2-(13)C]glycerol yields different results: rates of gluconeogenesis in healthy men measured with (2)H2O are higher than those measured with [2-(13)C]glycerol
    M T Ackermans
    Department of Clinical Chemistry, Laboratory of Endocrinology and Radiochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    J Clin Endocrinol Metab 86:2220-6. 2001
    The quantification of gluconeogenesis (GNG) by (2)H2O and [2-(13)C]glycerol and the mass isotopomer dilution analysis of glucose does not involve assumptions regarding the enrichment of the oxaloacetate precursor pool...
  71. pmc Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis
    Joseph T Rodgers
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 11:23-34. 2010
    ..Here, we show that Cdc2-like kinase 2 (Clk2) is an insulin-regulated suppressor of hepatic gluconeogenesis and glucose output...
  72. ncbi Can sugars be produced from fatty acids? A test case for pathway analysis tools
    Luis F de Figueiredo
    Department of Bioinformatics, Friedrich Schiller Universitat Jena, Ernst Abbe Platz 2, 07743 Jena, Germany
    Bioinformatics 25:152-8. 2009
    ..Using this example, we can compare the various methods in pathway analysis...
  73. ncbi Fructose-induced hepatic gluconeogenesis: effect of L-carnitine
    Panchamoorthy Rajasekar
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India
    Life Sci 80:1176-83. 2007
    ..The abnormalities associated with fructose feeding such as increased gluconeogenesis, reduced glycogen content and other parameters were brought back to near normal levels by CA...
  74. ncbi Renal gluconeogenesis: its importance in human glucose homeostasis
    J E Gerich
    Department of Medicine, University of Rochester, New York 14642, USA
    Diabetes Care 24:382-91. 2001
    ....
  75. ncbi Changes in subcellular localization of fructose 1,6-bisphosphatase during differentiation of isolated muscle satellite cells
    A Gizak
    Department of Animal Physiology, Institute of Zoology, Wroclaw University, Cybulskiego 30, 50 205 Wroclaw, Poland
    FEBS Lett 580:4042-6. 2006
    ..The data might suggest that FBPase participates in some nuclear processes during development and regeneration of skeletal muscle...
  76. ncbi Gluconeogenesis in humans with induced hyperlactatemia during low-intensity exercise
    Mark J Roef
    Department of Pediatric Gastroenterology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Am J Physiol Endocrinol Metab 284:E1162-71. 2003
    We studied the role of lactate in gluconeogenesis (GNG) during exercise in untrained fasting humans...
  77. ncbi Comparative effects of Stevia rebaudiana leaves and stevioside on glycaemia and hepatic gluconeogenesis
    Edilene Bega Ferreira
    Department of Pharmacy and Pharmacology, State University of Maringa, Maringa PR, Brazil
    Planta Med 72:691-6. 2006
    ..Bertoni (SRB) and stevioside (STV) on glycaemia and gluconeogenesis of 15-h fasted rats. For this purpose, the rats received SRB (20 mg/kg x day), STV (5...
  78. ncbi Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes
    M Otto
    Department of Hepatic Biochemistry, Novo Nordisk A S, Novo Nordisk Park, Denmark
    Diabetes Obes Metab 5:189-94. 2003
    ..Glycogen synthesis, and glucose and lactate production were examined in cultured rat hepatocytes preincubated with metformin (0-500 micro m) for 24 h...
  79. ncbi Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
    Kazuyuki Yamagata
    Center for Tsukuba Advanced Research Alliance, Aspect of Functional Genomic Biology, Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 279:23158-65. 2004
    ..These findings reveal a novel mechanism by which bile acids regulate gluconeogenic gene expression via an SHP-dependent regulatory pathway...
  80. ncbi Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis
    Kwang Hoon Song
    Department of Biochemistry and Molecular Pathology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    Hepatology 43:117-25. 2006
    ..In conclusion, this study unveils a species difference in nutrient regulation of the human and mouse CYP7A1 gene and suggests a discordant regulation of bile acid synthesis and gluconeogenesis by glucagon in human livers during fasting.
  81. ncbi Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects
    Michael F Nielsen
    Dept of Surgical Gastroenterology L, Aarhus Kommunehospital, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 286:E102-10. 2004
    ..To determine whether glucose effectiveness and, in terms of endogenous glucose release (EGR), gluconeogenesis, also are altered by hypercortisolemia, eight healthy subjects were studied after overnight infusion with ..
  82. ncbi Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism
    Monica Einstein
    Department of Metabolic Disorders, Merck Research Laboratories, P O Box 2000, Mail Code RY80N C31, Rahway, NJ 07065, USA
    J Steroid Biochem Mol Biol 92:345-56. 2004
    ..These NSGCAs might have useful applications as tools in metabolic research and drug discovery...
  83. ncbi Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
    X F Gao
    Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
    Diabetologia 52:912-20. 2009
    ..However, the underlying mechanism of this phenotype and the question of whether CPT1c is involved in the pathogenesis of diet-induced insulin resistance are unclear...
  84. ncbi Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt
    Jason T Dean
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA
    Cell Metab 9:525-36. 2009
    ..This work suggests that using non-native pathways in higher organisms to explore and modulate metabolism may be a useful approach...
  85. ncbi Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death
    Chien Chih Chen
    Division of Medicinal Chemistry, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    J Ethnopharmacol 117:483-90. 2008
    ..Fructus Corni, the fruits of Cornus officinalis Sieb. et Zucc., is one important ingredient in Quei Fu Di Huang Wan, a Chinese herbal mixture...
  86. pmc Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis
    Jochen K Lennerz
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 30:5043-56. 2010
    ..Thus, although Par-1a and Par-1b can compensate for one another during embryogenesis, their individual disruption gives rise to distinct metabolic phenotypes in adult mice...
  87. ncbi A novel function of intestinal gluconeogenesis: central signaling in glucose and energy homeostasis
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, U 855, Lyon, France
    Nutrition 25:881-4. 2009
    ..to the control of glucose homeostasis by its high glycolytic capacity and a recently described function, gluconeogenesis. In addition to its quantitative role in endogenous glucose production, a qualitative role of central ..
  88. ncbi Glucose production and gluconeogenesis in adults with cerebral malaria
    H van Thien
    Bao Loc General Hospital, Lamdong Province, Vietnam
    QJM 94:709-15. 2001
    Hypoglycaemia is an important complication in severe malaria, ascribed to an inhibition of gluconeogenesis. However, the only data available suggested that in severe malaria, total glucose production is increased...
  89. pmc Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis
    Young Sil Yoon
    Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Gyeonggi do 440 746, Korea
    Proc Natl Acad Sci U S A 107:17704-9. 2010
    Fasting promotes hepatic gluconeogenesis to maintain glucose homeostasis...
  90. ncbi Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet
    Margriet A B Veldhorst
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Human Biology, Maastricht University Medical Centre, Netherlands
    Am J Clin Nutr 90:519-26. 2009
    ..High-protein diets have been shown to increase energy expenditure (EE)...
  91. pmc Regulation of gluconeogenesis in Saccharomyces cerevisiae is mediated by activator and repressor functions of Rds2
    Nitnipa Soontorngun
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1
    Mol Cell Biol 27:7895-905. 2007
    ..Here, we unravel a key function of Rds2 in gluconeogenesis using chromatin immunoprecipitation-chip technology...
  92. ncbi Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
    Renaud Dentin
    Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 449:366-9. 2007
    ..Because TORC2 protein levels and activity were increased in diabetes owing to a block in TORC2 phosphorylation, our results point to an important role for this pathway in the maintenance of glucose homeostasis...
  93. pmc Acetone metabolism in mice: increased activity in mice heterozygous for obesity genes
    D L Coleman
    Proc Natl Acad Sci U S A 77:290-3. 1980
    ..The rate-limiting step in the pathway appears to be the conversion of acetone to a hydroxylated derivative. The enzyme system effecting this conversion is an NADPH-requiring microsomal oxygenase found in the liver...
  94. ncbi Hepatic autoregulation: response of glucose production and gluconeogenesis to increased glycogenolysis
    Peter Staehr
    Medical Endocrinological Department, Odense University Hospital, Odense, Denmark
    Am J Physiol Endocrinol Metab 292:E1265-9. 2007
    The effect of increased glycogenolysis, simulated by galactose's conversion to glucose, on the contribution of gluconeogenesis (GNG) to hepatic glucose production (GP) was determined...
  95. ncbi Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, U855, Universite de Lyon, Lyon, France
    Curr Opin Clin Nutr Metab Care 12:419-23. 2009
    ..It can also contribute to the control of glucose homeostasis via its high glycolytic capacity and a recently described function, gluconeogenesis.
  96. ncbi Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells
    A Barthel
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, Aachen, D 52057, Germany
    Biochem Biophys Res Commun 285:897-902. 2001
    ..These data suggest a specific function for FKHR in the regulation of hepatic gluconeogenesis at the level of G6Pase, but not PEPCK gene expression.
  97. ncbi Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle
    Emma De Fabiani
    Dipartimento di Scienze Farmacologiche, Facolta di Farmacia, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    J Biol Chem 278:39124-32. 2003
    ..transcription of the gene (PEPCK) encoding phosphoenolpyruvate carboxykinase, the rate-limiting enzyme in gluconeogenesis, through the same farnesoid X receptor-independent mechanism...
  98. pmc Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism
    P She
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Biol 20:6508-17. 2000
    ..Thus, hepatic PEPCK may function more as an integrator of hepatic energy metabolism than as a determinant of gluconeogenesis.
  99. pmc SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
    Derek M Erion
    Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven CT 06510, USA
    Proc Natl Acad Sci U S A 106:11288-93. 2009
    Hepatic gluconeogenesis is a major contributing factor to hyperglycemia in the fasting and postprandial states in type 2 diabetes mellitus (T2DM)...
  100. ncbi STAT3 targets the regulatory regions of gluconeogenic genes in vivo
    Preeti Ramadoss
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 23:827-37. 2009
    ..Thus STAT3 mediates negative regulation of hepatic gluconeogenic gene expression in vivo by interacting with regulatory regions of these genes...
  101. ncbi Higher insulin concentrations are required to suppress gluconeogenesis than glycogenolysis in nondiabetic humans
    Aron Adkins
    Endocrine Research Unit, Mayo Foundation, Rochester, Minnesota 55905, USA
    Diabetes 52:2213-20. 2003
    ..25, 0.375, or 0.5 mU. kg(-1). min(-1) and glucose was clamped at approximately 5.5 mmol/l. EGP, gluconeogenesis, and uridine-diphosphoglucose (UDP)-glucose flux were measured using [3-(3)H]glucose, deuterated water, and ..

Research Grants9

  1. HYPOGLYCEMIC ACTION OF 2-CHLOROPROPIONATE
    Robert Harris; Fiscal Year: 1980
    ..toxicity of dichloroacetate and 2-chloropropionate; (d) to determine the effects of 2-chloropropionate on gluconeogenesis, lipogenesis, ureagenesis, and fatty acid oxidation by liver cells; (e) to determine whether 2-..
  2. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1993
    The mechanisms by which hormones such as glucagon regulate hepatic gluconeogenesis are fairly well established...
  3. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1991
    Regulation of hepatic gluconeogenesis by hormones such as glucagon, insulin, epinephrine, vasopressin and angiotensin is well established...
  4. GLUCONEOGENESIS & DE NOVO LIPOGENESIS IN CYSTIC FIBROSIS
    DANA HARDIN; Fiscal Year: 2000
    ..Both gluconeogenesis and glycogenolysis contribute to HGP; however, their relative contribution to HGP in CF has not been ..
  5. ALTERNATIVE ROLES FOR PHOSPHOENOLPYRUVATE CARBOXYKINASE
    Paul Ray; Fiscal Year: 1991
    ..Most studies have used rat tissues to conclude that PEPCK in liver and kidney is essential to gluconeogenesis in all species...
  6. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..a key enzyme in the homeostatic regulation of blood glucose concentration, which catalyses the final step in gluconeogenesis and glycogenolysis...
  7. HORMONAL CONTROL OF HEPATIC GLUCONEOGENESIS/GLYCOLYSIS
    Alex Lange; Fiscal Year: 2005
    ..abstract_text> ..
  8. ENERGY HOMEOSTASIS BY SPECIFIC ORGANS IN SHOCK
    Frederick Pearce; Fiscal Year: 1992
    ..A critical event leading to loss of tolerance for hypovolemia is the failure of hepatic glucose production (gluconeogenesis and glycogenolysis) and lactate clearance...
  9. CONTROL MECHANISMS OF HEPATIC GLUCOSE OUTPUT
    John Clore; Fiscal Year: 2000
    ..Factors responsible for the increase in HGO are poorly understood. Increased gluconeogenesis is observed in patients with NIDDM...