Genomes and Genes
Summary: The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Publications287 found, 100 shown here
- Topographical continuity of bacterial populations in the healthy human respiratory tractEmily S Charlson
University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
Am J Respir Crit Care Med 184:957-63. 2011..However, studies of the lung are challenging due to difficulties in working with low biomass samples...
- Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammalsDebby van Riel
Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
Am J Pathol 171:1215-23. 2007..The PVA in human respiratory tract most closely mirrored that in ferrets and pigs for human influenza viruses and that in ferrets, pigs, and cats for avian influenza viruses...
- Deposition and biokinetics of inhaled nanoparticlesMarianne Geiser
Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
Part Fibre Toxicol 7:2. 2010..We emphasize the importance for quantitative analyses and the use of particle doses derived from real world exposures...
- Reassessment of the evidence for postcranial skeletal pneumaticity in Triassic archosaurs, and the early evolution of the avian respiratory systemRichard J Butler
GeoBio Center, Ludwig Maximilians Universitat Munchen, Munich, Germany
PLoS ONE 7:e34094. 2012....
- Deep sequencing analyses of low density microbial communities: working at the boundary of accurate microbiota detectionGiske Biesbroek
Department of Pediatric Infectious Diseases and Immunity UMC Utrecht, Utrecht, The Netherlands
PLoS ONE 7:e32942. 2012..This study was aiming to establish protocols for accurate microbiota analysis at low microbial density...
- The role of dendritic and epithelial cells as master regulators of allergic airway inflammationBart N Lambrecht
Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
Lancet 376:835-43. 2010....
- TRPA1 is a major oxidant sensor in murine airway sensory neuronsBret F Bessac
Department of Pharmacology and Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Clin Invest 118:1899-910. 2008..Our results indicate that TRPA1 is an oxidant sensor in sensory neurons, initiating neuronal excitation and subsequent physiological responses in vitro and in vivo...
- Branching morphogenesis of the Drosophila tracheal systemAmin Ghabrial
Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
Annu Rev Cell Dev Biol 19:623-47. 2003....
- Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and miceTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Science 325:484-7. 2009....
- Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosaVanja Klepac-Ceraj
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
Environ Microbiol 12:1293-303. 2010..aeruginosa, regardless of antibiotic exposure. This suggests that community composition might be a better predictor of disease progression than the presence of P. aeruginosa alone and deserves further study...
- Airway smooth muscle cell proliferation is increased in asthmaP R Johnson
Department of Pharmacology, University of Sydney, Sydney, Australia
Am J Respir Crit Care Med 164:474-7. 2001..05). This study shows for the first time that proliferation of ASM cells is increased in patients with asthma and provides evidence for an intrinsic abnormality in the ASM cell in this disease...
- The polymicrobial nature of airway infections in cystic fibrosis: Cangene Gold Medal LectureChristopher D Sibley
Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
Can J Microbiol 57:69-77. 2011..The microbiology of CF airways may serve as a model to investigate the emergent properties of other clinically relevant microbial communities in the human body...
- Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma modelP S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Exp Med 183:195-201. 1996..These results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease...
- Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilienceFranziska Anne Stressmann
Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, 150 Stamford Street, Franklin Wilkins Building, London SE1 9NH, UK
Thorax 67:867-73. 2012..However, little is known about their clinical significance or persistence in CF airways...
- The guinea pig as a transmission model for human influenza virusesAnice C Lowen
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
Proc Natl Acad Sci U S A 103:9988-92. 2006..Our results demonstrate that influenza virus can pass between guinea pigs by means of droplet spread and thereby establish the suitability of the guinea pig as a model host for influenza virus transmission studies...
- Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tractMichael C W Chan
Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
Am J Pathol 176:1828-40. 2010..These findings are therefore relevant for understanding transmission and therapy...
- Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometryWhitney W Stevens
The Carter Immunology Center, UVa Health Sciences Center, Charlottesville, VA 22908, United States
J Immunol Methods 327:63-74. 2007..Furthermore, this flow cytometry-based method can be directly adapted to enumerate eosinophils infiltrating the inflamed lung parenchyma, thereby obviating the need for quantitative morphometry of tissue sections...
- Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferretsVincent J Munster
National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
Science 325:481-3. 2009..These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences...
- A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmissionTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Science 315:655-9. 2007..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals...
- Avian influenza receptor expression in H5N1-infected and noninfected human tissuesLu Yao
Department of Pathology, School of Basic Medical Sciences, Peking Beijing University, 38 Xueyuan Rd, 100083 Beijing, China
FASEB J 22:733-40. 2008..Finally, the relative lack of AIV-Rs in the upper airway may be a one of the factors preventing efficient human-to-human transmission of H5N1 influenza...
- Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infectionsRobert Tarran
Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7248, USA
J Biol Chem 280:35751-9. 2005....
- Nitric oxide in health and disease of the respiratory systemFabio L M Ricciardolo
Dept of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
Physiol Rev 84:731-65. 2004....
- High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI)David W Parsons
Department of Pulmonary Medicine, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia
J Anat 213:217-27. 2008..The coupling of phase-contrast synchrotron X-ray imaging technology with software-based reconstruction techniques holds promise for novel and high-resolution non-invasive examination of airspace anatomy in small animal models...
- Risks from accidental exposures to engineered nanoparticles and neurological health effects: a critical reviewMyrtill Simko
Austrian Academy of Sciences, Institute of Technology Assessment, Vienna, Austria
Part Fibre Toxicol 7:42. 2010..Crucial deficits include lack of exposure data, the absence of a proper dose concept, and that studies often fail in adequate description of the investigated ENPs...
- Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airwaysArjun Guha
Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 109:12592-7. 2012....
- Effect of airway opening on production of exhaled particlesAnn Charlotte Almstrand
Occupational and Environmental Medicine at Sahlgrenska Academy, Box 414, SE 405 30 Gothenburg, Sweden
J Appl Physiol (1985) 108:584-8. 2010..Our results show that airway reopening following airway closure is an important mechanism for formation of endogenous exhaled particles and that these particles originate from the terminal bronchioles...
- Cystic fibrosis: a disease of vulnerability to airway surface dehydrationRichard C Boucher
Cystic Fibrosis Pulmonary Research and Treatment Center and the UNC Virtual Lung Group, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Trends Mol Med 13:231-40. 2007..Recent clinical studies indicate that inhalation of hypertonic saline osmotically draws sufficient water onto CF airway surfaces to provide clinical benefit...
- Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndromeBernard Lambermont
Hemodynamic Research Center, HemoLiege, University of Liege, Belgium
Crit Care 12:R91. 2008....
- Targeted cell replacement with bone marrow cells for airway epithelial regenerationAmy P Wong
Latner Thoracic Surgery Research Laboratories, McEwen Centre for Regenerative Medicine, Toronto Lung Transplant Program, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada
Am J Physiol Lung Cell Mol Physiol 293:L740-52. 2007..Some BMC cultured in vitro over time also expressed GFP transgene, suggesting epithelial transdifferentiation of the BMC. The results indicate that targeted delivery of BMC can promote airway regeneration...
- Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigsSharon M Brookes
Veterinary Laboratories Agency Weybridge, EU OIE FAO Reference Laboratory for Avian Influenza and Newcastle Disease, Addlestone, Surrey, United Kingdom
PLoS ONE 5:e9068. 2010..These findings provide potential clues to the existence and biological significance of viral receptor-binding variants with 225D and 225G during the 1918 pandemic ...
- Time course of endotoxin-induced airways' inflammation in healthy subjectsVirginie Doyen
Clinics of Immuno allergology, CHU Brugmann, Universite Libre de Bruxelles ULB, pl Van Gehuchten, 4, 1020, Brussels, Belgium
Inflammation 35:33-8. 2012..When repeated endotoxin inhalations are used as a model of inflammation, a wash-out period of at least 7 days should be applied between each exposure in each subject...
- Upper respiratory tract microbial communities, acute otitis media pathogens, and antibiotic use in healthy and sick childrenMelinda M Pettigrew
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA
Appl Environ Microbiol 78:6262-70. 2012..51; 95% CI, 0.31 to 0.83). An increased understanding of polymicrobial interactions will facilitate the development of effective AOM prevention strategies...
- Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatasesBelaid Bouazza
Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, PA 19107 5233, USA
Am J Respir Cell Mol Biol 47:464-73. 2012..We propose that the novel mechanism that proasthmatic cytokine-induced CSI in ASMCs is due, in part, to PP5-mediated impairment of GR-Ser211 phosphorylation...
- Pulmonary pneumaticity in the postcranial skeleton of extant aves: a case study examining AnseriformesPatrick M O'Connor
Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, Ohio 45701, USA
J Morphol 261:141-61. 2004..Finally, enigmatic pneumatic features located in distal forelimb elements of screamers (Anhimidae) result from invasion of bone by a network of subcutaneous air sac diverticula spreading distally along the wings...
- Oral and airway microbiota in HIV-infected pneumonia patientsShoko Iwai
University of California San Francisco, San Francisco, California, USA
J Clin Microbiol 50:2995-3002. 2012....
- Well-differentiated human airway epithelial cell culturesM Leslie Fulcher
Cystic Fibrosis, Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, NC, USA
Methods Mol Med 107:183-206. 2005
- Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the moleculeD J Thornton
The Wellcome Trust Centre for Cell Matrix Research, University of Manchester, 2 205, Stopford Building, Manchester M139PT, United Kingdom
J Biol Chem 272:9561-6. 1997....
- Interleukin-17 and airway remodellingAnders Linden
Department of Medicine, Cooperative Research Centre for Chronic Inflammatory Diseases, The University of Melbourne, Parkville, Vic, Australia
Pulm Pharmacol Ther 19:47-50. 2006..If this is the case, then IL-17A may constitute a useful target for pharmacotherapeutic intervention in allergic airway disease...
- Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscleReinoud Gosens
Department of Physiology, University of Manitoba, Winnipeg, Canada
Am J Physiol Lung Cell Mol Physiol 291:L523-34. 2006..As such, caveolae and caveolin-1 coordinate PDGF receptor signaling, leading to myocyte proliferation, and inhibit constitutive activity of p42/p44 MAPK to sustain cell quiescence...
- Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivoKim L Roberts
Department of Virology, Imperial College London, St Mary s Campus, London W2 1PG, UK
J Gen Virol 92:1822-31. 2011....
- Multidetector computed tomography (MDCT) for preoperative airway assessment in children with mucopolysaccharidosesP M Ingelmo
First Service of Anesthesia and Intensive Care, San Gerardo Hospital, Monza, Italy
Minerva Anestesiol 77:774-80. 2011..However, MDCT has not been recommended in MPS children. The aim of this clinical scenario study was to verify whether information from MDCT reconstruction of the airway is useful in airway management planning of children with MPS...
- Mucoactive agents for airway mucus hypersecretory diseasesDuncan F Rogers
Airway Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, United Kingdom
Respir Care 52:1176-93; discussion 1193-7. 2007..It is noteworthy that, of the more complex molecules in development, it is simple inhaled hypertonic saline that is currently receiving the greatest attention as a mucus therapy, primarily in CF...
- Segregation of virulent influenza A(H1N1) variants in the lower respiratory tract of critically ill patients during the 2010-2011 seasonal epidemicAntonio Piralla
Struttura Semplice Virologia Molecolare, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
PLoS ONE 6:e28332. 2011..Since its appearance in 2009, the pandemic influenza A(H1N1) virus circulated worldwide causing several severe infections...
- The airway microbiota in cystic fibrosis: a complex fungal and bacterial community--implications for therapeutic managementLaurence Delhaes
Center for Infection and Immunity of Lille CIIL, Institut Pasteur de Lille, Biology and Diversity of Emerging Eukaryotic Pathogens BDEEP, BP 245, Lille, France
PLoS ONE 7:e36313. 2012..In this study, we developed a pyrosequencing approach to extensively explore the diversity and dynamics of fungal and prokaryotic populations in CF lower airways...
- The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cellsNing Yang
State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Tsinghua University, Chinese Academy of Medical Sciences, Beijing, China
J Mol Cell Biol 3:221-9. 2011..Therefore, we discovered that the 2009 pandemic H1N1 strain, A/Wenshan/01/2009, can induce apoptotic cell death in epithelial cells of the human respiratory tract, suggesting a molecular pathogenesis for the 2009 pandemic H1N1...
- Avian influenza h6 viruses productively infect and cause illness in mice and ferretsLaura Gillim-Ross
Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
J Virol 82:10854-63. 2008..However, we have identified an H6 virus that induces protective immunity against viruses in the North American and Eurasian lineages...
- Experimental infection of mice with avian paramyxovirus serotypes 1 to 9Sunil K Khattar
Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
PLoS ONE 6:e16776. 2011..Taken together, these results demonstrate that all APMV serotypes except APMV-5 are capable of replicating in mice with minimal disease and pathology...
- Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1Mary E B Martino
Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 284:14904-13. 2009..These findings suggest that, in inflamed HBE, XBP-1s is responsible for the ER/Ca(2+) store expansion that confers amplification of Ca(2+)-dependent inflammatory responses...
- Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosisAmanda L Brennan
Glucose and Pulmonary Infection Group, St George s, University of London, Room 66, Ground Floor Jenner Wing, Cardiac and Vascular Sciences Respiratory, Cranmer Terrace, SW17 0RE, London, United Kingdom
J Cyst Fibros 6:101-9. 2007..In people without CF, airway glucose (AG) concentrations are elevated when blood glucose (BG)> or =8 mmol L(-1) (airway threshold), and are associated with acquisition of respiratory infection...
- Afferent neural pathways in cough and reflex bronchoconstrictionJ A Karlsson
Pharmacological Laboratory, AB Draco, Lund, Sweden
J Appl Physiol (1985) 65:1007-23. 1988..Although cough and bronchoconstriction may be mediated by the same type of receptor, they seem to have separate afferent neural pathways...
- Effect of aging on respiratory system physiology and immunologyGulshan Sharma
Division of Allergy, Pulmonary, Immunology, Critical Care, and Sleep APICS, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0561, USA
Clin Interv Aging 1:253-60. 2006..of the elderly population of the US, a thorough understanding of "normal" aging-related changes on the respiratory system is paramount...
- Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tractJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 83:7075-84. 2009..These findings demonstrate that avian influenza viruses within H7 and H5 subtypes are capable of using the eye as a portal of entry...
- Influenza A virus receptors in the respiratory and intestinal tracts of pigeonsYuehuan Liu
Institute of Animal and Husbandry Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, PR China
Avian Pathol 38:263-6. 2009..Overall, the results suggest that SAalpha2,6Gal is the major receptor in the pigeon airway, which may partly contribute to the resistance of pigeons to Asian lineage HPAIV subtype H5N1...
- Physiological changes in respiratory function associated with ageingJ P Janssens
Dept of Geriatrics, Geneva University Hospital, Switzerland
Eur Respir J 13:197-205. 1999..In spite of these changes, the respiratory system remains capable of maintaining adequate gas exchange at rest and during exertion during the entire lifespan, ..
- Airway epithelial cell signaling in response to bacterial pathogensMarisa I Gomez
Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Pediatr Pulmonol 43:11-9. 2008..The major signaling cascades initiated by epithelial receptors that lead to phagocyte recruitment to the airways as well as the ability of the epithelium to regulate inflammation are discussed...
- Ozone activates airway nerves via the selective stimulation of TRPA1 ion channelsThomas E Taylor-Clark
Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD, USA
J Physiol 588:423-33. 2010..Thus, ozone is not an indiscriminate neuronal activator, but rather it potently and selectively activates a subset of airway C-fibres by directly stimulating TRPA1...
- Respiratory microbiology of patients with cystic fibrosis in the United States, 1995 to 2005Samiya Razvi
Department of Pediatrics, Columbia University, New York, NY 10032, USA
Chest 136:1554-60. 2009..Numerous improvements in diagnostic and therapeutic strategies for patients with cystic fibrosis (CF) have occurred during the past 2 decades. We hypothesized that these changes could impact trends in respiratory microbiology...
- Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responsesG Harata
Technical Research Laboratory, Takanashi Milk Products Co, Ltd, Yokohama, Kanagawa, Japan
Lett Appl Microbiol 50:597-602. 2010..To investigate whether intranasal Lactobacillus administration protects host animals from influenza virus (IFV) infection by enhancing respiratory immune responses in a mouse model...
- Modulation of dendritic cell trafficking to and from the airwaysClaudia Jakubzick
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
J Immunol 176:3578-84. 2006....
- The allergic mouse model of asthma: normal smooth muscle in an abnormal lung?Scott Wagers
Vermont Lung Center, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Appl Physiol (1985) 96:2019-27. 2004..This has implications for the pathophysiology of asthma and suggests that at least some types of asthma may benefit from therapies aimed at manipulating surface tension at the air-liquid interface in the lungs...
- Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussisPeter McGuirk
Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
J Exp Med 195:221-31. 2002..The induction of Tr1 cells after interaction of a pathogen-derived molecule with cells of the innate immune system represents a novel strategy exploited by an infectious pathogen to subvert protective immune responses in vivo...
- The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of miceMichelle D Tate
Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia
Respir Res 9:57. 2008....
- Vagal afferent nerves regulating the cough reflexBrendan J Canning
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Respir Physiol Neurobiol 152:223-42. 2006..Whether these "cough receptors" are the guinea pig equivalent of the irritant receptors described in the extrapulmonary airways of other species is unclear...
- Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slicesYan Bai
Department of Physiology, University of Massachusetts Medical School, Worcester, 01655, USA
Am J Physiol Lung Cell Mol Physiol 291:L208-21. 2006....
- Comparative in vitro study of interactions between particles and respiratory surface macrophages, erythrocytes, and epithelial cells of the chicken and the ratS G Kiama
Department of Veterinary Anatomy and Physiology, University of Nairobi, P O Box 30197, Nairobi, Kenya
J Anat 213:452-63. 2008In mammals, surface macrophages (SMs) play a foremost role in protecting the respiratory system by engulfing and destroying inhaled pathogens and harmful particulates...
- Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanismPeter R A Johnson
Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
J Allergy Clin Immunol 113:690-6. 2004..We have previously shown that nonasthmatic ASM cells in culture produce a range of extracellular matrix protein proteins and that asthmatic ASM cells proliferate faster than cells from nonasthmatic patients...
- No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammationSteven C Gribar
Division of Pediatric Surgery, Department of Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Mol Med 14:645-59. 2008..Recent work in support of these concepts is extensively reviewed, while essential areas of further study that are required to determine the significance of epithelial TLR signaling during states of health and disease are outlined...
- Expression patterns of influenza virus receptors in the respiratory tracts of four species of poultryJi Eun Yu
Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 143 701, Korea
J Vet Sci 12:7-13. 2011..These results indicate that pheasants and quails may play important roles as intermediate hosts for the generation of influenza viruses with pandemic potential...
- Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9Arthur S Samuel
Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
Vet Res 42:38. 2011..Taken together, these results demonstrate that all nine known APMV serotypes are capable of replicating in hamsters with minimal disease and pathology...
- Suppression of ovalbumin-induced Th2-driven airway inflammation by β-sitosterol in a guinea pig model of asthmaShailaja G Mahajan
Department of Pharmacology, L M College of Pharmacy, Ahmedabad, Gujarat, India
Eur J Pharmacol 650:458-64. 2011..sitosterol possesses anti-asthmatic actions that might be mediated by inhibiting the cellular responses and subsequent release/synthesis of Th2 cytokines. This compound may have therapeutic potential in allergic asthma...
- Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cellsJames P Garnett
Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
J Biol Chem 286:41069-82. 2011....
- Allergic rhinitis and inflammatory airway disease: interactions within the unified airspaceBradley F Marple
Department of Otolaryngology Head and Neck Surgery, UT Southwestern Medical Center at Dallas, Dallas, Texas 75390 9035, USA
Am J Rhinol Allergy 24:249-54. 2010....
- Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferretsIsabelle Meunier
INRS Institut Armand Frappier, Laval, Quebec, Canada
Virology 422:125-31. 2012..This virus was also associated with a rapid and sustained induction of inflammatory cytokines, indicating that early dysregulation of the host response contributes importantly to the disease outcome...
- Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tractAliete Langsdorf
Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
Am J Respir Cell Mol Biol 44:293-301. 2011....
- Local innate immune responses and influenza virus transmission and virulence in ferretsTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 205:474-85. 2012..Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression...
- Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell culturesKrzysztof Pyrc
Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
J Virol 84:11255-63. 2010....
- Influenza A and B virus attachment to respiratory tract in marine mammalsAntonio J Ramis
Universitat Autonoma de Barcelona, Barcelona, Spain
Emerg Infect Dis 18:817-20. 2012..Attachment of avian influenza A viruses (H4N5) and (H7N7) and human influenza B viruses to trachea and bronchi of harbor seals is consistent with reported influenza outbreaks in this species...
- Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipientsJ Kuypers
University of Washington, Seattle, Washington, USA
Transpl Infect Dis 11:298-303. 2009..To evaluate the relative sensitivity of respiratory virus detection in specimens from HCT recipients, we compared the results of conventional and quantitative molecular methods...
- Enhanced viral etiological diagnosis of respiratory system infection outbreaks by use of a multitarget nucleic acid amplification assaySallene Wong
Provincial Laboratory for Public Health Microbiology, 3030 Hospital Drive NW, Calgary, Alberta T2N 4W4, Canada
J Clin Microbiol 47:3839-45. 2009..8% of outbreaks using a combination of DFA, NATs, and RVP. Use of RVP enhances the laboratory investigation of respiratory virus outbreaks and facilitates appropriate patient and outbreak management...
- Antimicrobial polypeptides in host defense of the respiratory tractTomas Ganz
University of California Los Angeles School of Medicine, Center for the Health Sciences, 10833 LeConte Avenue, 37 055, Los Angeles, CA 90095 1690, USA
J Clin Invest 109:693-7. 2002
- Heterosubtypic immunity to influenza A virus in mice lacking IgA, all Ig, NKT cells, or gamma delta T cellsK A Benton
Molecular Immunology Laboratory, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA
J Immunol 166:7437-45. 2001....
- Transient receptor potential A1 channels: insights into cough and airway inflammatory diseaseMaria G Belvisi
Respiratory Pharmacology, Airway Disease Section, National Heart and Lung Institute, and the Centre for Integrative Physiology and Pharmacology, Faculty of Medicine, Imperial College London, London, England
Chest 140:1040-7. 2011....
- Detection and quantification of human metapneumovirus in pediatric specimens by real-time RT-PCRJane Kuypers
Department of Laboratory Medicine, University of Washington, CHRMC, 4800 Sand Point Way N E, Virology Office, G 815, 8G 3, Seattle, WA 98105, USA
J Clin Virol 33:299-305. 2005..Human metapneumovirus (h MPV), a recently identified virus, causes respiratory illness in children...
- G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthmaGustavo Nino
Division of Pulmonary Medicine, Children s Hospital of Philadelphia Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 7:e32078. 2012....
- The impact of sugar cane-burning emissions on the respiratory system of children and the elderlyJosé E D Cançado
Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, University of Sao Paulo Medical School, Sao Paulo, Brazil
Environ Health Perspect 114:725-9. 2006We analyzed the influence of emissions from burning sugar cane on the respiratory system during almost 1 year in the city of Piracicaba in southeast Brazil...
- Symmorphosis and the insect respiratory system: allometric variationEdward P Snelling
School of Earth and Environmental Sciences, University of Adelaide, South Australia 5005, Australia
J Exp Biol 214:3225-37. 2011Taylor and Weibel's theory of symmorphosis predicts that structures of the respiratory system are matched to maximum functional requirements with minimal excess capacity...
- Caveolin-1 regulation of store-operated Ca(2+) influx in human airway smooth muscleVenkatachalem Sathish
Dept of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Eur Respir J 40:470-8. 2012..These results demonstrate that caveolar expression and regulation of proteins such as Orai1 are important for [Ca(2+)](i) regulation in human ASM cells and its modulation during inflammation...
- Respiratory evolution facilitated the origin of pterosaur flight and aerial gigantismLeon P A M Claessens
Department of Biology, College of the Holy Cross, Worcester, MA, USA
PLoS ONE 4:e4497. 2009..present various lines of skeletal evidence that indicate that pterosaurs had a highly effective flow-through respiratory system, capable of sustaining powered flight, predating the appearance of an analogous breathing system in birds by ..
- Neutrophils sustain effective CD8(+) T-cell responses in the respiratory tract following influenza infectionMichelle D Tate
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
Immunol Cell Biol 90:197-205. 2012..Therefore, neutrophils are important participants in anti-viral mechanisms that sustain effective CD8(+) T-cell responses in the respiratory tract of influenza virus-infected mice...
- Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes studyJ Barenfanger
Laboratory Medicine, Memorial Medical Center, Springfield, Illinois 62781, USA
J Clin Microbiol 38:2824-8. 2000..Summarizing, the cytospin FA markedly decreased turnaround time and was associated with decreased mortality, length of stay, and costs and with better antibiotic stewardship...
- KI polyomavirus detected in respiratory tract specimens from patients in St. Louis, MissouriDavid J Hormozdi
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Pediatr Infect Dis J 29:329-33. 2010..So far, evidence has not supported a link between infections with either virus and respiratory tract disease; however, there has not been a large comparison of KIPyV-infected patients to age-matched patient groups...
- Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in miceT Hori
Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 1868650, Japan
Clin Diagn Lab Immunol 8:593-7. 2001..These findings suggest that intranasal administration of LcS enhances cellular immunity in the respiratory tract and protects against influenza virus infection...
- Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammalJack L Feldman
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Appl Physiol 100:2096-7; discussion 2097-8, 2103-8. 2006
- Acyl homoserine lactones induce early response in the airwayAndrea Sbarbati
Department of Morphological Biomedical Sciences, Section of Human Anatomy and Histology, University of Verona, Verona, Italy
Anat Rec (Hoboken) 292:439-48. 2009..Our results show that AHL action is not limited to activation of conspecific bacteria, but also modifies innate airway defense mechanisms...
- Studying bacteria in respiratory specimens by using conventional and molecular microbiological approachesGeraint B Rogers
King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
BMC Pulm Med 9:14. 2009..Here, the aim was to determine the extent to which routine diagnostic microbiology gave a different assessment of the species present in sputa when analysed by using culture-independent assessment...
- An in vitro model of differentiated human airway epithelia. Methods for establishing primary culturesPhilip H Karp
Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, USA
Methods Mol Biol 188:115-37. 2002
- Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesiaD S Southam
Asthma Research Group and Firestone Institute of Respiratory Health, Department of Medicine, McMaster University, 50 Charlton Avenue E, Hamilton, Ontario, Canada L8N 4A6
Am J Physiol Lung Cell Mol Physiol 282:L833-9. 2002..When using intranasal instillation, the relative distribution between the URT and LRT and the gastrointestinal tract is heavily influenced by delivery volume and level of anesthesia...
- An alternative approach to the identification of respiratory central chemoreceptors in the brainstemC Jiang
Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30302 4010, USA
Respir Physiol 129:141-57. 2001..1-Kir5.1 contributes to the CO(2)/pH sensitivity in these neurons. We believe that this line of research intended to identify CO(2) sensing molecules is an important addition to current studies on the CCRs...
- Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodelingJason R Rock
Department of Cell Biology, Nanaline Duke Building, Duke University Medical Center, Durham, NC 27710, USA
Dis Model Mech 3:545-56. 2010....
- The structure and function of carbonic anhydrase isozymes in the respiratory system of vertebratesA J Esbaugh
Department of Biology, Queen s University, Kingston, Ont, Canada K7L 3N6
Respir Physiol Neurobiol 154:185-98. 2006..This review will examine the structural characteristics that are integral to CAs participation in respiration, as well as highlight the specific roles and tissues that the different CA isozymes are involved in...
- Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory systemN Watanabe
Sackler Institute of Pulmonary Pharmacology, Pharmaceutical Sciences Research Division, School of Biomedical and Health Sciences, King s College London, St Thomas Street, London SE1 1UL, UK
Neuroscience 141:1533-43. 2006....
- Nanoparticle Coupled Antioxidants for Respiratory Illness in VeteransRODNEY JON SCHLOSSER; Fiscal Year: 2013..We will use a murine model of allergic fungal rhinosinusitis with exacerbation by smoke or DEP exposure to determine the efficacy of antiMUC1-SOD/CAT-NPs. ..
- Community Participation Research of Breastfeeding Disparities in African AmericanTamar Ringel Kulka; Fiscal Year: 2009..E.S.T (Breastfeeding, Education &Support Team) Alliance for Babies} and propose to conduct community participation research of breastfeeding disparities in African American women in Durham County, North Carolina. ..
- Molecular mechanisms of lung disease in ataxia telangiectasiaJoAnn M Sekiguchi; Fiscal Year: 2013..neurodegeneration;however, in addition to cancer, one of the leading causes of morbidity and mortality is respiratory system disease, including interstitial lung disease (ILD)...
- ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and caRobert J Thomas; Fiscal Year: 2010..We propose to show its usefulness as a monitor of sleep in health, in those with simple and complicated forms of sleep apnea, and in patients with heart failure. ..
- Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasiaJeffrey A Whitsett; Fiscal Year: 2010..This project will identify potential therapeutic targets and molecules that will provide the basis for future therapies of these chronic lung diseases that, together, comprise a major health problem world-wide. ..
- Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary HypertensionC Michael Hart; Fiscal Year: 2013..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
- Pilot Studies of the Effect of Aging on Mucociliary ClearanceLawrence E Ostrowski; Fiscal Year: 2013..The ion transport properties of the upper and lower airways wil be determined, as these are reflective of the hydration status of the ASL. Tissue samples from mice 3, 6, 12, and 24 months old will be studied in Ussing chambers. ..
- PARP Inhibitor and Redox Catalyst for Ventilatory TraumaPrakash Jagtap; Fiscal Year: 2013..Lung mechanics will be evaluated hourly, allowing for determination of: 1) dynamic respiratory system compliance, 2) resistance and hysteresivity derived from dynamic pressure volume loops, and 3) static ..
- Vaccine Assembly from Surface Proteins of Staphylococcus AureusOlaf Schneewind; Fiscal Year: 2013..abstract_text> ..
- Genetic Epidemiology of Life-Threatening Influenza Infection in ChildrenAdrienne Randolph; Fiscal Year: 2009..abstract_text> ..
- Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B CellsHARRY BERNARD GREENBERG; Fiscal Year: 2010..Influenza infection kills over 35,000 people in the United States each year. These studies will provide new information to enhance our ability to improve the influenza vaccines. ..
- Pulmonary Defenses Against Intracellular InfectionShawn J Skerrett; Fiscal Year: 2013....
- Repair of Airway Epithelium Following Chlorine Lung InjuryGary W Hoyle; Fiscal Year: 2011..S. civilians could be adversely affected by highly toxic chemicals released intentionally in terrorist attacks or unintentionally in industrial accidents or natural disasters. ..
- Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and SexBRITT HOLMEN; Fiscal Year: 2010..Despite numerous studies examining the effects of petroleum diesel (petrodiesel) exhaust emissions on the respiratory system, the mechanisms responsible for the reported adverse human health effects and pinpointing the particulate&..
- Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic ChildrenToby C Lewis; Fiscal Year: 2013..laboratory and epidemiologic evidence to suggest that air pollution and URIs have interactive effects on the respiratory system. We have shown, in a prior epidemiologic study, that asthmatics with cold symptoms show more changes in lung ..
- Development of an effective therapy against post-exposure AnthraxMaurizio Pellecchia; Fiscal Year: 2010..This rod shaped bacterium infects humans through the respiratory system, skin, or digestive tract. Dependent upon the entry route into the human body, Anthrax can be highly lethal...
- Moraxella catarrhalis: virulence-based preventionTimothy F Murphy; Fiscal Year: 2013..There is a renewed enthusiasm for vaccines for otitis media given recent promising clinical trials, creating a momentum of feasibility for this approach. ..
- Mechanisms of Haemophilus influenzae pathogenesis in the lungHao Shen; Fiscal Year: 2013....
- Innate Immunity, Biomarkers and Myocardial InfarctionGregory L Stahl; Fiscal Year: 2010....
- Antimicrobial Peptides and Innate Immunity in Otitis MediaLauren O Bakaletz; Fiscal Year: 2012....
- High-throughput Screenings to Identify Host Receptors for Staphylococcal AdhesinsRenata Pasqualini; Fiscal Year: 2012..Our research aims to better understand staphylococcal infection and to set the grounds for targeted therapies against this disease. ..
- Prevention and therapy of Staphylococcus aureus infectionsOlaf Schneewind; Fiscal Year: 2010..These technologies will be developed with the goal of generating a vaccine and immune therapeutics, thereby providing protection against S. aureus infections and improving global health. ..
- Novel immunotherapeutics for the management of otitis media due to H. influenzaeSteven D Goodman; Fiscal Year: 2013..e. hearing loss due to OM), a goal of Strategic Plan Priority Area I. ..
- Bordetella Cyclase Toxin:Effect on Leukocytes and Respiratory Epithelial CellsErik L Hewlett; Fiscal Year: 2013....
- Clinical Impact of Human Coronaviruses and Viral DiversityGeoffrey J Gorse; Fiscal Year: 2012....
- Single RNA sensitive probes for studying viral replication and buddingPhilip J Santangelo; Fiscal Year: 2013....
- Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell PlatformsERIK MILLS SCHWIEBERT; Fiscal Year: 2010..DBM will utilize a deep panel of immortalized human cells derived from skin (keratinocytes), respiratory system (nasal, airway and lung epithelial cells) and renal system (proximal tubule, cortical, and medullary kidney ..
- Biomarkers of Sudden Death and Progressive Heart FailureGORDON FRANK TOMASELLI; Fiscal Year: 2010....
- A Trial of Zinc and Micronutrients in Tanzanian ChildrenChristopher P Duggan; Fiscal Year: 2010..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
- Hospital and Household Studies of Respiratory Cryptosporidiosis and TransmissionJeffrey K Griffiths; Fiscal Year: 2013..We wish to see if it can be spread from, or to, the lungs, like influenza or tuberculosis. If it can spread in this way, then we can prevent people from getting infected by actions such as wearing masks and washing hands after coughing. ..
- Function of mRNA Editing in TrypanosomesStephen L Hajduk; Fiscal Year: 2010..coding genes thus allowing the translation of edited mRNAs to produce components of the mitochondrial respiratory system. While this is certainly an important function for RNA editing we recently discovered that primary mRNAs are ..
- Mechanism of PsrP mediated adhesionCarlos J Orihuela; Fiscal Year: 2013..We will determine if passive vaccination with mAbs and active vaccination with recombinant BR constructs protects mice against pneumococcal challenge. ..
- H. influenzae: Role of Sialic Acid in VirulenceMichael A Apicella; Fiscal Year: 2013..Finally, studies of isolates from human subjects colonized with NTHi 2019strR will examine the role of phase variation on LOS structure and determine if foreign DNA is acquired by NTHi during colonization. ..
- Role of Staphylococcus aureus alpha-hemolysin in diseaseJuliane Bubeck Wardenburg; Fiscal Year: 2013..These studies are expected to shed light on elements of host susceptibility to S. aureus disease, and contribute more broadly to our understanding of bacterial pore forming cytotoxins. ..
- Biology of the HMW1 and HMW2 Adhesins of H. InfluenzaeJOSEPH W ST. GEME; Fiscal Year: 2013..influenzae disease. More generally, these studies will provide fundamental insights into host-microbial relationships, bacterial protein secretion, and prokaryotic protein glycosylation. ..
- Developmental Physiology of Ciliated EpitheliaCHRISTOPHER ROBERT KINTNER; Fiscal Year: 2012....
- Peptide inhbitors of influenza entry-FAST TRACKRussell B Wilson; Fiscal Year: 2011....
- H. influenzae: Role of Sialic Acid in VirulenceMichael Apicella; Fiscal Year: 2009..abstract_text> ..
- MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCHMARK WALTER FRAMPTON; Fiscal Year: 2013..Research by these young investigators will improve our understanding of how the respiratory system responds to injury and environmental challenges, and will improve public health by developing new and ..
- Perinatal Stress and programming of childhood wheeze and lung functionRosalind J Wright; Fiscal Year: 2013..normal course of lung morphogenesis and maturation, potentially impacting both structure and function of the respiratory system. Moreover, when normal development is altered, the early effects may persist into adult life, magnifying the ..
- IL8-induced Post-transcriptional Regulation of the MUC5AC mucin geneMary C Rose; Fiscal Year: 2010..This will be fundamental for formulating therapeutic interventions for lung diseases that manifest with mucin overproduction. ..
- Mechanisms of Haemophilus influenzae pathogenesis in the lungHao Shen; Fiscal Year: 2011..abstract_text> ..
- Genetic Epidemiology of Life-Threatening Influenza in ChildrenAdrienne G Randolph; Fiscal Year: 2013..Understanding of the role of the innate immune and inflammatory response in children with life-threatening and fatal influenza infection could provide new targets for future preventive (immune adjuvant) and therapeutic approaches. ..
- Immune Regulation of Virus Clearance and Tissue Injury at Sites of InfectionThomas J Braciale; Fiscal Year: 2013..To determine the impact of viral infection on the production of Te-derived IL- 10. The proposed studies are designed to complement ongoing related studies in Projects 2, 3 and 4. ..
- Transcriptional Control of Submucosal Gland Formation and FunctionJeffrey A Whitsett; Fiscal Year: 2013..This proposal seeks to determine the cellular and molecular basis underlying AEC and SMG morphogenesis and function relevant to the pathogenesis of recurrent infections caused by defects in mucociliary clearance. ..
- A Mucosal RSV VaccineKejian Yang; Fiscal Year: 2013....
- Pregnancy Folate Status &Early Childhood Respiratory &Atopic Disease OutcomesKECIA NICOLE CARROLL; Fiscal Year: 2013..This study has potential to inform prenatal recommendations and identify modifiable risk factors for asthma and atopy. ..
- Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic PreemiesRITA MARIE RYAN; Fiscal Year: 2013..The future of many vulnerable children depends on this pioneering approach to the Prematurity and Respiratory Outcomes Program, PROP. ..
- Neutrophil Accumulation in Bacterial PneumoniaSamithamby Jeyaseelan; Fiscal Year: 2013....
- Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cellsPaul R Knight; Fiscal Year: 2010..This treatment stimulates immunity against influenza virus, as well as interferes with the virus'ability to do damage to the airways. ..
- Long-lived B cell Immunity in the Respiratory TractNicole Baumgarth; Fiscal Year: 2013..This basic information will provide potential avenues for rational vaccine design that aims to boost local/mucosal immune responses. ..
- Antenatal Dietary Supplementation is a Risk Factor for Infant Atopy Through EpigeDAVID ALBERT SCHWARTZ; Fiscal Year: 2010..Our research team proposes to determine if such concerns about methyl donor supplementation are justified and pose a real threat in expectant mothers already at risk for transmitting an atopic genetic predisposition to their infants. ..
- Point of care microfluidic diagnosis system for rapid and sensitive detection ofMichel G Bergeron; Fiscal Year: 2013..These POCTs will help public health authorities to define new operational strategies for both lab-based and field-based applications. ..
- Heme, Iron and Oxidative Stress: Regulation of Iron Homeostasis in H. InfluenzaeRobert S Munson; Fiscal Year: 2013..abstract_text> ..
- Yeast Based Assays for Chemical Screens Against SARS-CoV TargetsDANIEL A contact ENGEL; Fiscal Year: 2010..We hypothesize that we can learn about the biology of SARS-CoV by identifying which chemical compounds can inhibit it, and then study how they work. ..
- Bordetella Biofilms and PathogenesisRAJENDAR K DEORA; Fiscal Year: 2011..coli and Yersinia Spp, and possibly others, our results will contribute towards the treatment and the understanding of a wide variety of bacterial infections. ..
- Novel Biomarkers Predictive of Heparin-Induced ThrombocytopeniaBarbara A Konkle; Fiscal Year: 2010..This study will help identify patients most at risk of developing HIT with heparin therapy so that the approach to their care can be altered, and thus, improved. ..
- Age-associated Toll-like receptor dysfunction in the lungsCarlos J Orihuela; Fiscal Year: 2010..This proposal will determine if alveolar macrophages and mucosal epithelial cells, the primary point of contact for respiratory tract pathogens in the lungs, experience ADTD. ..
- Enterovirus Vectors with Respiratory Tropism for Cancer ImmunotherapyMatthias Gromeier; Fiscal Year: 2010..We are testing a new type of vaccine based on a common cold- causing virus targeting these pathways. We will evaluate our immunization technology in a novel animal model for the common cold. ..
- Hazard Assessment and Risk Estimation of Inhaled Nanomaterials ExposureGunter Oberdorster; Fiscal Year: 2010..These results will be used to develop and validate short-term tests that can be used for estimating potential human risk following ENM exposure. ..
- Ozone, apoE4, aging, and Alzheimer's diseaseRui Ming Liu; Fiscal Year: 2013..that O3 inhalation also causes oxidative stress and pathological changes in other tissues/organs beyond the respiratory system. Interestingly, it has been reported that children and young adults living in urban areas with high levels ..
- Role of TLR4 in Coronavirus InfectionSteven M Varga; Fiscal Year: 2010..This information will provide novel approaches for therapeutic intervention of respiratory coronavirus infections and aid in the design of future coronavirus vaccines. ..
- Lung Injury and Shock Pathogenesis in Y. pestis SepsisANDREW LECHNER; Fiscal Year: 2006..Aims 3 and 4 to be completed in Year 2 within BSL-3 labs.] ..
- Nasal dosimetry of diacetyl and butyric acid vaporsJohn Morris; Fiscal Year: 2005....
- Targeted Therapies for Selected Phenotypes of Obstructive Sleep ApneaJerome A Dempsey; Fiscal Year: 2010..Accordingly, we hypothesize that correcting respiratory system instability will improve airway patency and breathing for those patients who are characterized by a ..
- TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASEThomas Platts Mills; Fiscal Year: 1999....
- Azithromycin to prevent BPD in Ureaplasma-infected Preterms: Single Dose PK studyRose Viscardi; Fiscal Year: 2009..This study will evaluate the safety and pharmacokinetics (how the body processes the drug) of the antibiotic azithromycin in preterm babies at risk for the Ureaplasma infection and the complication BPD. ..
- Transmission and the respiratory tract in cryptosporidiosisJeffrey Griffiths; Fiscal Year: 2007..This study is important to public health because it may help us to understand if the parasite also causes a lung infection in children. [unreadable] [unreadable] [unreadable]..
- Function of NALT in nasal immunization to heterotypic strains of influenzaTroy D Randall; Fiscal Year: 2010..This information will be essential for the development of vaccines that promote long-lasting cross-reactive immunity to influenza, a virus that continues to be an emerging infectious disease. ..
- LUNG AND AIRWAY AFFERENTS AND THEIR REFLEX ROLEJOHN COLERIDGE; Fiscal Year: 1992....
- Effect of Pertussis Toxin on Cough in Guinea PigNICHOLAS CARBONETTI; Fiscal Year: 2005..abstract_text> ..
- Cell Entry of Human MetapneumovirusJohn Williams; Fiscal Year: 2009..These studies will increase understanding of how hMPV causes disease in humans, and may help develop targets for antiviral medicines and vaccines. ..
- Acoustic and Respiratory System Correlates of PausingJanet Slifka; Fiscal Year: 2009..Current models of speech production assign a largely passive role to the respiratory system, yet preliminary data indicate that pauses are actively generated by re-adjustments of the respiratory ..
- LUNG SURFACE ANTIOXIDANT DEFENSES AGAINST AIR POLLUTANTSCARROLL CROSS; Fiscal Year: 2000..This information is likely to increase our understanding of lung injury due to inhalation of air pollutants, and will enable development of strategies to prevent lung injury by inhaled oxidants. ..
- Novel approaches to evaluate carbon nanotube health impactsKENT ED PINKERTON; Fiscal Year: 2010..Inhalation of SWCNTs causes cellular injury, oxidative stress, and changes in biochemical homeostasis in the respiratory system of exposed animals;(2) SWCNT particle retention patterns and impaired macrophage function are associated ..
- INNERVATION OF THE MAXILLARY SINUS IN RATSKEITH KAJANDER; Fiscal Year: 1993..Inflammation of the upper respiratory system clearly is a major problem for many people in the United States...
- Role of Pertussis Toxin in Bordetella pertussis infectionNicholas H Carbonetti; Fiscal Year: 2010..pertussis infection will increase our understanding of the pathogenic mechanisms of this organism, and may lead to novel therapeutic approaches to combat pertussis infection and disease. ..
- CORONAVIRUS-RECEPTOR INTERACTIONSKathryn Holmes; Fiscal Year: 2003..Inhibition of HCoV-229E respiratory infection by candidate drugs will be studied in transgenic mice that express the HCoV-229E receptor, hAPN, in the respiratory epithelium. ..
- Inhalation Dosimetry/Exposure Index of Fiber AerosolYung Sung Cheng; Fiscal Year: 2006..Sampling devices based on this size-selection definition can be developed in the future for improved assessment of worker exposure. ..
- Improved Lung Delivery of Medical Aerosols through Enhanced Condensation GrowthP Worth Longest; Fiscal Year: 2010..The overall goal of this project is to develop a novel technology for the efficient delivery of inhaled medicines that minimizes deposition in the mouth and throat and maximizes deposition in the lungs. ..