Summary: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.

Top Publications

  1. ncbi Sox9 is required for cartilage formation
    W Bi
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 22:85-9. 1999
  2. ncbi Novel regulators of bone formation: molecular clones and activities
    J M Wozney
    Tissue Growth and Repair Program, Genetics Institute, Inc, Cambridge, MA 02140
    Science 242:1528-34. 1988
  3. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
  4. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
  5. ncbi Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    A Vortkamp
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 273:613-22. 1996
  6. ncbi A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells
    W J Wan Ju Li
    Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Biomaterials 26:599-609. 2005
  7. ncbi In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    B Johnstone
    Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Exp Cell Res 238:265-72. 1998
  8. ncbi A two-color acid-free cartilage and bone stain for zebrafish larvae
    M B Walker
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Biotech Histochem 82:23-8. 2007
  9. pmc Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    E Schipani
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 15:2865-76. 2001
  10. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999

Detail Information

Publications337 found, 100 shown here

  1. ncbi Sox9 is required for cartilage formation
    W Bi
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 22:85-9. 1999
    ..b>Cartilage formation begins with the condensation of mesenchyme cells followed by their differentiation into chondrocytes...
  2. ncbi Novel regulators of bone formation: molecular clones and activities
    J M Wozney
    Tissue Growth and Repair Program, Genetics Institute, Inc, Cambridge, MA 02140
    Science 242:1528-34. 1988
    Protein extracts derived from bone can initiate the process that begins with cartilage formation and ends in de novo bone formation...
  3. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
    ..a rigid material capable of sustaining mechanical force; pathological calcification can occur in arteries and cartilage and other soft tissues. No molecular determinant regulating ECM calcification has yet been identified...
  4. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
    ..Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy...
  5. ncbi Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    A Vortkamp
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 273:613-22. 1996
    ..Ihh is expressed in the prehypertrophic chondrocytes of cartilage elements, where it regulates the rate of hypertrophic differentiation...
  6. ncbi A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells
    W J Wan Ju Li
    Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Biomaterials 26:599-609. 2005 a chondrocytic phenotype, as evidenced by chondrocyte-specific gene expression and synthesis of cartilage-associated extracellular matrix (ECM) proteins...
  7. ncbi In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    B Johnstone
    Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Exp Cell Res 238:265-72. 1998
    ..These results provide histological, immunohistochemical, and molecular evidence for the in vitro chondrogenic differentiation of adult mammalian progenitor cells derived from bone marrow...
  8. ncbi A two-color acid-free cartilage and bone stain for zebrafish larvae
    M B Walker
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Biotech Histochem 82:23-8. 2007
    Traditionally, cartilage is stained by alcian blue using acidic conditions to differentiate tissue staining...
  9. pmc Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    E Schipani
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 15:2865-76. 2001
  10. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
    ..Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes...
  11. ncbi PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth
    B Lanske
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 273:663-6. 1996
    ..These results suggest that the PTH/PTHrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation...
  12. pmc High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing
    Jazia Alblowi
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts, USA
    Am J Pathol 175:1574-85. 2009
    ..gene sets related to inflammation, including tumor necrosis factor (TNF) signaling in the diabetic group, when cartilage is being replaced by bone on day 16, but not on days 12 or 22...
  13. ncbi The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
    L-Sox5 and Sox6 are highly identical Sry-related transcription factors coexpressed in cartilage. Whereas Sox5 and Sox6 single null mice are born with mild skeletal abnormalities, Sox5; Sox6 double null fetuses die with a severe, ..
  14. pmc Adult mesenchymal stem cells and cell-based tissue engineering
    Rocky S Tuan
    National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 5:32-45. 2003
    ..Future research should aim to define the cellular and molecular fingerprints of MSCs and elucidate their endogenous role(s) in normal and abnormal tissue functions...
  15. pmc Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
    Masaki Inada
    Center for Immunology and Inflammatory Diseases, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Building 149, 13th Street, Room 8301, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 101:17192-7. 2004
    ..the functional roles of Mmp13, we generated Mmp13-null mice that showed profound defects in growth plate cartilage with markedly increased hypertrophic domains as well as delay in endochondral ossification and formation and ..
  16. pmc Engineering cartilage tissue
    Cindy Chung
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 S 33rd Street, Philadelphia, PA 19104, USA
    Adv Drug Deliv Rev 60:243-62. 2008
    b>Cartilage tissue engineering is emerging as a technique for the regeneration of cartilage tissue damaged due to disease or trauma...
  17. ncbi Endochondral ossification: how cartilage is converted into bone in the developing skeleton
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:46-62. 2008
    ..During endochondral ossification, chondrocytes proliferate, undergo hypertrophy and die; the cartilage extracellular matrix they construct is then invaded by blood vessels, osteoclasts, bone marrow cells and ..
  18. doi Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction
    Siyoung Yang
    Cell Dynamics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    Nat Med 16:687-93. 2010
    Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and catabolic factors...
  19. ncbi Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia
    M Ridanpaa
    Folkhalsan Institute of Genetics, 00280 Helsinki, Finland
    Cell 104:195-203. 2001
    The recessively inherited developmental disorder, cartilage-hair hypoplasia (CHH) is highly pleiotropic with manifestations including short stature, defective cellular immunity, and predisposition to several cancers...
  20. ncbi Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow
    A M Mackay
    Osiris Therapeutics, Inc, Baltimore, Maryland 21231 2001, USA
    Tissue Eng 4:415-28. 1998
    ..marrow retain the capacity to proliferate and differentiate along multiple connective tissue lineages, including cartilage. In this study, culture-expanded human MSCs (hMSCs) of 60 human donors were induced to express the morphology ..
  21. doi β-Defensin-4 (HBD-4) is expressed in chondrocytes derived from normal and osteoarthritic cartilage encapsulated in PEGDA scaffold
    Giuseppe Musumeci
    Department of Bio Medical Sciences, Anatomy Section, University of Catania, Italy
    Acta Histochem 114:805-12. 2012
    ..The aim of this study was to investigate β-defensin-4 expression in chondrocytes taken from articular cartilage of knees of patients with osteoarthritis (OA) compared to normal cartilage, in vivo in explanted tissue, and in ..
  22. pmc Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis
    Mary B Goldring
    Tissue Engineering, Regeneration, and Repair Program, Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY 10021, USA
    Eur Cell Mater 21:202-20. 2011
    Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation from superficial to deep layers and from loaded to unloaded zones...
  23. doi C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes
    Makoto Hirata
    Sensory and Motor System Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Mol Genet 21:1111-23. 2012
    ..compound knockout of Cebpb and Runx2 in mice caused growth retardation and resistance to OA with decreases in cartilage degradation and matrix metalloproteinase-13 (Mmp-13) expression...
  24. ncbi Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells
    Christopher J Centeno
    Regenerative Sciences Inc RSI, Centeno Schultz Clinic, Westminster, CO 80020, USA
    Pain Physician 11:343-53. 2008
    ..will highlight the developments in cellular medicine that may soon permit interventional pain management physicians to treat a much wider variety of clinical conditions and highlight an interventional case study using these technologies..
  25. pmc Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis
    Mary B Goldring
    Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY 10021, USA
    Trends Mol Med 18:109-18. 2012
    ..Alterations in the normal pattern of chondrocyte gene control in cartilage facilitate the onset and progression of OA...
  26. doi Extracellular matrix scaffolds for cartilage and bone regeneration
    Kim E M Benders
    Department of Orthopedics, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Trends Biotechnol 31:169-76. 2013
    ..This review describes the rationale for using ECM-based approaches for different regenerative purposes and details the application of ECM for cartilage or osteochondral repair.
  27. pmc FGF10 controls the patterning of the tracheal cartilage rings via Shh
    Frederic G Sala
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Development 138:273-82. 2011
    ..embryonic development, appropriate dorsoventral patterning of the trachea leads to the formation of periodic cartilage rings from the ventral mesenchyme and continuous smooth muscle from the dorsal mesenchyme...
  28. doi Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis
    Elizaveta Kon
    Biomechanics Laboratory III Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Arthroscopy 27:1490-501. 2011
    The aim of our study is to compare the efficacy of platelet-rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra-articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA).
  29. pmc Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy
    Claire Vinatier
    INSERM, U 791, LIOAD, Nantes, F 44042, France
    Curr Stem Cell Res Ther 4:318-29. 2009
    Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair...
  30. doi Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development
    Catharine A Hellingman
    Department of Otorhinolaryngology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Tissue Eng Part A 16:545-56. 2010
    Adult mesenchymal stem cells (MSCs) are considered promising candidate cells for therapeutic cartilage and bone regeneration...
  31. pmc A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene
    V Lefebvre
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 11, Houston, TX 77030, USA
    EMBO J 17:5718-33. 1998
    ..Our data suggest that L-Sox5/Sox6 and Sox9, which belong to two different classes of Sox transcription factors, cooperate with each other in expression of Col2a1 and possibly other genes of the chondrocytic program...
  32. doi Cartilage in normal and osteoarthritis conditions
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Montreal, Canada
    Best Pract Res Clin Rheumatol 22:351-84. 2008
    The preservation of articular cartilage depends on keeping the cartilage architecture intact. Cartilage strength and function depend on both the properties of the tissue and on their structural parameters...
  33. ncbi Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation
    Michael R Lang
    Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Genet 38:1198-203. 2006
    ..crusher chondrocytes accumulate proteins in a distended endoplasmic reticulum, resulting in severe reduction of cartilage extracellular matrix (ECM) deposits, including type II collagen...
  34. doi Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture
    Daniel B F Saris
    Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 37:10S-19S. 2009
    Damaged articular cartilage has limited capacity for self-repair...
  35. ncbi Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration
    Esther Schnapp
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 132:3243-53. 2005
    ..requires the coordinated growth and patterning of the regenerating tissues types, including the spinal cord, cartilage and muscle...
  36. ncbi The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage
    Toshiyuki Ikeda
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN The Institute of Physical and Chemical Research, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Rheum 50:3561-73. 2004
    To regenerate permanent cartilage, it is crucial to know not only the necessary conditions for chondrogenesis, but also the sufficient conditions. The objective of this study was to determine the signal sufficient for chondrogenesis.
  37. doi Cartilage engineering: a crucial combination of cells, biomaterials and biofactors
    Claire Vinatier
    INSERM, U 791, LIOAD, Nantes, F 44042, France
    Trends Biotechnol 27:307-14. 2009
    Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair...
  38. ncbi Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification
    Makoto Hirao
    Department of Orthopaedics, Osaka University Graduate School of Medicine, 2 2 Yamadoaka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:31079-92. 2006
    b>Cartilage functions at a lower oxygen tension than most other tissues...
  39. doi SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
    Development 137:901-11. 2010
    SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events...
  40. ncbi A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:1069-83. 2005
    ..amplification is important for discerning the origins of vertebrate novelties, including neural crest, placodes, cartilage and bone...
  41. pmc Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy
    Linda K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Clin Invest 122:2652-60. 2012
    ..we observed that Borrelia burgdorferi antigens, but not infectious spirochetes, can remain adjacent to cartilage for extended periods after antibiotic treatment. B...
  42. doi Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis
    Yiying Qi
    Department of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China
    Mol Biol Rep 39:5683-9. 2012
    Osteoarthritis (OA) is a common disorder and the restoration of the diseased articular cartilage in patients with OA is still a challenge for researchers and clinicians...
  43. pmc MicroRNA-140 plays dual roles in both cartilage development and homeostasis
    Shigeru Miyaki
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Genes Dev 24:1173-85. 2010
    ..aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation, mediated by several proteinases, including Adamts-5...
  44. doi Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament
    Yuki Sugimoto
    Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Development 140:2280-8. 2013
    SRY-box containing gene 9 (Sox9) and scleraxis (Scx) regulate cartilage and tendon formation, respectively...
  45. doi Aggrecan: Beyond cartilage and into the brain
    M Morawski
    Paul Flechsig Institute of Brain Research, Faculty of Medicine, Universitat Leipzig, Germany
    Int J Biochem Cell Biol 44:690-3. 2012
    Aggrecan is well-studied in cartilage but its expression and function in the central nervous system has only recently begun to be appreciated...
  46. pmc Lubricin is expressed in chondrocytes derived from osteoarthritic cartilage encapsulated in poly (ethylene glycol) diacrylate scaffold
    G Musumeci
    Department of Bio Medical Sciences, Human Anatomy Section, University of Catania, Italy
    Eur J Histochem 55:e31. 2011
    ..characterized by degenerative changes within joints that involved quantitative and/or qualitative alterations of cartilage and synovial fluid lubricin, a mucinous glycoprotein secreted by synovial fibroblasts and chondrocytes...
  47. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    ..Genetic deletion of Mef2c or expression of a dominant-negative MEF2C mutant in endochondral cartilage impairs hypertrophy, cartilage angiogenesis, ossification, and longitudinal bone growth in mice...
  48. ncbi Long-term stable fibrin gels for cartilage engineering
    Daniela Eyrich
    Department of Pharmaceutical Technology, University of Regensburg, Universitaetsstrasse 31, 93051 Regensburg, Germany
    Biomaterials 28:55-65. 2007
    ..that hydrogel scaffold systems maintain long-term shape stability and mechanical integrity for applications in cartilage tissue engineering...
  49. doi Primary culture and phenotyping of murine chondrocytes
    Marjolaine Gosset
    Paris Universitas Université Pierre et Marie Curie Paris VI, Department of Physiology and Physiopathology, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7079, 7 quai St Bernard, Paris 75252 Cedex 5, France
    Nat Protoc 3:1253-60. 2008
    ..chondrocytes of different anatomical origins (articular and costal chondrocytes, both of which represent hyaline cartilage) from mice...
  50. pmc Proteases involved in cartilage matrix degradation in osteoarthritis
    Linda Troeberg
    The Kennedy Institute of Rheumatology Division, Imperial College London, London, UK
    Biochim Biophys Acta 1824:133-45. 2012
    ..Degradation of the cartilage extracellular matrix is a central feature of the disease and is widely thought to be mediated by proteinases ..
  51. ncbi High hydrostatic pressure, a novel approach in orthopedic surgical oncology to disinfect bone, tendons and cartilage
    Peter Diehl
    Department of Orthopedic Surgery, University of Rostock, Germany
    Anticancer Res 28:3877-83. 2008
    ..HHP is also an attractive novel approach to effectively kill vegetative microorganisms or tumor cells in bone, cartilage and tendon ex vivo while leaving the tissues' mechanical properties unimpaired, thus allowing reimplantation of ..
  52. doi Peter Pan functions independently of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis
    Verena Bugner
    Institute for Biochemistry and Molecular Biology, Ulm University, Albert Einstein Allee 11, D 89081 Ulm, Germany
    Development 138:2369-78. 2011
    ..and interference with rRNA processing using antisense morpholino oligonucleotides resulted in eye and cranial cartilage malformations...
  53. pmc Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis
    Muneaki Ishijima
    Department of Medicine for Motor Organ, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Arthritis Res Ther 13:R22. 2011
    ..We tested the hypothesis that there exist relationships between the onset of early stage radiographically defined knee osteoarthritis (OA), pain and changes in biomarkers of joint metabolism...
  54. doi Cartilage biology, pathology, and repair
    Daniel Umlauf
    Institute of Experimental Musculoskeletal Medicine IEMM, University Hospital Muenster, Domagkstrasse 3, 48149, Muenster, Germany
    Cell Mol Life Sci 67:4197-211. 2010
    ..Although great efforts have been made to investigate cartilage biology and osteoarthritis pathology, the treatment has lagged behind that of other arthritides, as there is a ..
  55. pmc Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
    Miriam Bellido
    Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Avda, Reyes Catolicos, 2, 28040 Madrid, Spain
    Arthritis Res Ther 12:R152. 2010
    Osteoporosis (OP) increases cartilage damage in a combined rabbit model of OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at subchondral bone aggravates cartilage damage in this experimental model.
  56. pmc Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells
    Brian O Diekman
    Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 109:19172-7. 2012
    The development of regenerative therapies for cartilage injury has been greatly aided by recent advances in stem cell biology...
  57. doi Cartilage development and degeneration: a Wnt Wnt situation
    Katherine Ann Staines
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, Scotland
    Cell Biochem Funct 30:633-42. 2012
    ..Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function...
  58. ncbi Nonlinear analysis of cartilage in unconfined ramp compression using a fibril reinforced poroelastic model
    L P Li
    Departments of Chemical Engineering, Institute of Biomedical Engineering, Ecole Polytechnique of Montreal, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada
    Clin Biomech (Bristol, Avon) 14:673-82. 1999
    To develop a biomechanical model for cartilage which is capable of capturing experimentally observed nonlinear behaviours of cartilage and to investigate effects of collagen fibril reinforcement in cartilage.
  59. pmc Perlecan maintains the integrity of cartilage and some basement membranes
    M Costell
    Department of Experimental Pathology, Lund University, S 221 85 Lund, Sweden
    J Cell Biol 147:1109-22. 1999
    Perlecan is a heparan sulfate proteoglycan that is expressed in all basement membranes (BMs), in cartilage, and several other mesenchymal tissues during development...
  60. ncbi Mesenchymal stem cell therapy to rebuild cartilage
    David Magne
    INSERM EM 99 03, 1 place A Ricordeau, 44042 Nantes Cedex 1, France
    Trends Mol Med 11:519-26. 2005
    Disorders affecting cartilage touch almost the whole population and are one of the leading causes of invalidity in adults...
  61. ncbi Conserved molecular program regulating cranial and appendicular skeletogenesis
    B Frank Eames
    Dev Dyn 231:4-13. 2004
    The majority of in vivo studies on bone and cartilage differentiation are carried out using the appendicular skeleton as a model system, with the implicit assumption that skeletal formation is equivalent throughout the body...
  62. ncbi Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements
    Steven M Sperber
    Department of Cellular and Molecular Medicine, University of Ottawa, and Ottawa Health Research Institute, Canada
    Dev Biol 314:59-70. 2008
    ..We show that embryos injected with dlx1a and dlx2a MOs exhibit reduced and dysmorphic arch cartilage elements...
  63. ncbi Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung
    Leigh Anne D Miller
    Department of Pediatrics, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Dev Dyn 231:57-71. 2004
    ..was ectopically expressed in the respiratory epithelium; however, peripheral expression of SHH failed to correct cartilage abnormalities in the trachea and bronchi, indicating a spatial requirement for SHH expression near sites of ..
  64. pmc Post-translational Regulation of Runx2 in Bone and Cartilage
    J H Jonason
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    J Dent Res 88:693-703. 2009
    ..In this review, we discuss expression of Runx2 during development as well as the post-translational regulation of Runx2 through modification by phosphorylation, ubiquitination, and acetylation...
  65. pmc Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation
    B Frank Eames
    Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America
    PLoS Genet 7:e1002246. 2011
    ..whether PGs regulate interactions between chondrocytes and perichondrium, using zebrafish mutants to reveal that cartilage PGs inhibit chondrocyte maturation, which ultimately dictates the timing of perichondral bone development...
  66. doi Regulation of bone and cartilage development by network between BMP signalling and transcription factors
    Riko Nishimura
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
    J Biochem 151:247-54. 2012
    Bone morphogenetic protein(s) (BMP) are very powerful cytokines that induce bone and cartilage formation. BMP also stimulate osteoblast and chondrocyte differentiation...
  67. ncbi Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes
    Guangyao Liu
    Departments of Cartilage and Bone Regeneration Fujisoft, and Sensory and Motor System Medicine, Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 282:20407-15. 2007
    Since permanent cartilage has poor self-regenerative capacity, its regeneration from autologous human chondrocytes using a tissue engineering technique may greatly benefit the treatment of various skeletal disorders...
  68. doi Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation
    Ling Wu
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 17:1425-36. 2011
    ..of primary chondrocytes (PCs) with various sources of multipotent cells results in a higher relative amount of cartilage matrix formation than cultures containing only chondrocytes...
  69. ncbi Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development
    Joy Lincoln
    Division of Molecular Cardiovascular Biology, MLC 7020, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 294:292-302. 2006
    ..have identified specific regulatory pathways that are active in the developing valve structures and also control cartilage, tendon, and bone development...
  70. ncbi Delayed gadolinium-enhanced MR to determine glycosaminoglycan concentration in reparative cartilage after autologous chondrocyte implantation: preliminary results
    Atsuya Watanabe
    Departments of Orthopaedic Surgery and Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Radiology 239:201-8. 2006
    To prospectively evaluate delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage for assessment of glycosaminoglycan (GAG) concentration in reparative cartilage after autologous chondrocyte implantation (ACI).
  71. ncbi Biomarkers of muscle and cartilage damage and inflammation during a 200 km run
    Hyo Jeong Kim
    Human Physiology, Korea National Sport University, Olympic Park, 88 15 Oryun dong, Songpa Gu, Seoul, South Korea
    Eur J Appl Physiol 99:443-7. 2007
    ..However, ultra-marathon related information is scarce. The present study evaluated muscle and cartilage biomarkers, and cytokine secretion during a 200 km running event...
  72. ncbi Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone
    Shinichiro Kume
    Department of Orthopaedic Surgery, Kurume University School of Medicine, Kurume, Japan
    J Bone Miner Res 20:1647-58. 2005
    ..the proliferation of MSCs, induced apoptosis, and prevented cognate differentiation into adipose tissue, cartilage, and bone, suggesting a deleterious effect of AGEs in the pathogenesis of musculoskeletal disorders in aged and ..
  73. ncbi Assessment of early osteoarthritis in hip dysplasia with delayed gadolinium-enhanced magnetic resonance imaging of cartilage
    Young Jo Kim
    Children s Hospital, Boston, Massachusetts 02115, USA
    J Bone Joint Surg Am 85:1987-92. 2003
    ..treatment of osteoarthritis is difficult to assess because of the lack of a noninvasive, sensitive measure of cartilage integrity...
  74. ncbi Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development
    Ava E Brent
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 132:515-28. 2005
    Proper formation of the musculoskeletal system requires the coordinated development of the muscle, cartilage and tendon lineages arising from the somitic mesoderm...
  75. doi Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases
    Rodolfo Gomez
    Research Laboratory 9, NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago University Clinical Hospital, Santiago de Compostela, Spain
    J Mol Endocrinol 43:11-8. 2009
    ..Herein, we review recent adipokine research, with particular emphasis to the role of leptin, adiponectin, resistin, and visfatin in chondrocyte function and skeleton, as well as in inflammatory and degenerative cartilage joint diseases.
  76. ncbi Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation
    M Rehli
    Department of Hematology and Oncology, University of Regensburg, Germany
    Genomics 43:221-5. 1997
    ..We sequenced 1.3 kb of the 5'-flanking region and identified a variety of putative regulatory elements...
  77. ncbi Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports
    Shigeyuki Wakitani
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Cell Transplant 13:595-600. 2004
    ..effectiveness of autologous bone marrow stromal cell transplantation for the repair of full-thickness articular cartilage defects in the patellae of a 26-year-old female and a 44-year-old male...
  78. ncbi Gene and protein expression of brain-derived neurotrophic factor and TrkB in bone and cartilage
    T Yamashiro
    Department of Orthodontics, Okayama University Dental School, Okayama, Japan
    Bone 28:404-9. 2001
    ..showed overlapped expression in chondrocytes in proliferating and mature zones of the epiphyseal growth plate cartilage and mandibular condylar cartilage, and in cuboidal-shaped active osteoblasts at the site of endochondral and ..
  79. doi Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue
    Linyi Peng
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Stem Cells Dev 17:761-73. 2008
    Mesenchymal stem cells (MSCs) isolated from bone marrow (BM), cartilage, and adipose tissue (AT) possess the capacity for self-renewal and the potential for multilineage differentiation, and are therefore perceived as attractive sources ..
  80. ncbi Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells
    Hani A Awad
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Tissue Eng 9:1301-12. 2003
    ..The addition of dexamethasone appeared to amplify protein synthesis but had suppressive effects on proteoglycan synthesis and accumulation...
  81. ncbi BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells
    I Sekiya
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Biochem Biophys Res Commun 284:411-8. 2001
    Marrow stromal cells (MSCs) can differentiate into several mesenchymal lineages. MSCs were recently shown to form cartilage in micromass cultures with serum-free medium containing TGF-beta and dexamethasone...
  82. ncbi Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis
    Roberto E Guzman
    Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Toxicol Pathol 31:619-24. 2003
    ..OA) is a degenerative joint disease characterized by joint pain and a progressive loss of articular cartilage. Studies to elucidate the pathophysiology of OA have been hampered by the lack of a rapid, reproducible animal ..
  83. ncbi Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function
    H Watanabe
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda MD 20892, USA
    J Biochem 124:687-93. 1998
    Aggrecan, a large aggregating proteoglycan, is one of the major structural components of cartilage. Its core protein contains three glubular domains and two glycosaminoglycan-attachment domains...
  84. ncbi Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, A 5020 Salzburg, Austria
    NMR Biomed 19:822-54. 2006
    ..analysis technology has recently started to generate a great wealth of quantitative information on articular cartilage and bone physiology, pathophysiology and degenerative changes in osteoarthritis...
  85. pmc Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization
    W Bi
    Department of Molecular Genetics and Graduate Program in Genes and Development, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:6698-703. 2001
    ..died perinatally with cleft palate, as well as hypoplasia and bending of many skeletal structures derived from cartilage precursors. In embryonic day (E)14...
  86. ncbi Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis
    Michael Klüppel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Development 132:3989-4003. 2005
    ..groups to the 4-O-position in chondroitin, causes severe chondrodysplasia characterized by a disorganized cartilage growth plate as well as specific alterations in the orientation of chondrocyte columns...
  87. ncbi Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins
    M D Tortorella
    Department of Inflammatory Diseases Research, DuPont Pharmaceuticals Company, Wilmington, DE 19880 0400, USA
    Science 284:1664-6. 1999
    ..purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases...
  88. ncbi Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull
    Naoyuki Wada
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3977-88. 2005
    ..vital dye labeling to generate a fate map, we show that distinct populations of neural crest form the two main cartilage elements of the larval anterior neurocranium: the paired trabeculae and the midline ethmoid...
  89. doi The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis
    Erika H Noss
    Division of Rheumatology, Allergy, and Immunology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 223:252-70. 2008
    ..Greater understanding of how FLS are activated and how they interact with other cells in the RA synovium may provide insights that allow development of novel agents for RA therapy...
  90. ncbi Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
    L J Brunet
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720 3204, USA
    Science 280:1455-7. 1998
    ..Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs...
  91. ncbi Regulatory mechanisms in the pathways of cartilage and bone formation
    B de Crombrugghe
    The University of Texas M D Anderson Cancer Center, Department of Molecular Genetics, 1515 Holcombe Boulevard, Box 11, Houston, Texas 77030, USA
    Curr Opin Cell Biol 13:721-7. 2001
  92. ncbi In vitro cartilage tissue engineering with 3D porous aqueous-derived silk scaffolds and mesenchymal stem cells
    Yongzhong Wang
    Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
    Biomaterials 26:7082-94. 2005
    Adult cartilage tissue has limited self-repair capacity, especially in the case of severe damages caused by developmental abnormalities, trauma, or aging-related degeneration like osteoarthritis...
  93. pmc Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation
    Lei Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Suite 402A, 1 Hoppin Street, Providence RI 02903, USA
    Dev Biol 341:236-45. 2010
    ..In organ culture SDF-1 infiltrates cartilage and accelerates growth plate hypertrophy...
  94. ncbi Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells
    Jae Sung Kim
    Department of Life Sciences, Research Center for Biomolecular Nanotechnology, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    J Biol Chem 282:29359-67. 2007
    To identify novel molecules regulating chondrogenesis and cartilage development, we screened a cartilage-specific expressed sequence tag data base...
  95. ncbi Healing full-thickness cartilage defects using adipose-derived stem cells
    Jason L Dragoo
    Orthopedic Tissue Regeneration Laboratory, Department of Orthopedic Surgery, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Tissue Eng 13:1615-21. 2007
    ..of this study was to evaluate the use of adipose-derived stem cells (ADSCs) as a source for full-thickness cartilage repair in an animal model...
  96. ncbi The control of chondrogenesis
    Mary B Goldring
    Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute and Harvard Medical School, Boston, MA 02115, USA
    J Cell Biochem 97:33-44. 2006
    ..condensation of progenitors, and chondrocyte differentiation, and maturation and resulting in the formation of cartilage and bone during endochondral ossification...
  97. doi Improved cartilage regeneration utilizing mesenchymal stem cells in TGF-beta1 gene-activated scaffolds
    Huajia Diao
    Department of Orthopaedics Surgery, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Jinling Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, China
    Tissue Eng Part A 15:2687-98. 2009
    Recently, bone marrow-derived mesenchymal stem cells (MSCs) have been paid more attention for cartilage regeneration...
  98. doi Cartilage tissue engineering using funnel-like collagen sponges prepared with embossing ice particulate templates
    Hongxu Lu
    Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    Biomaterials 31:5825-35. 2010
    ..To investigate the effects of different pore structures on cartilage regeneration, the funnel-like collagen sponges were used to culture bovine articular chondrocytes...
  99. ncbi Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo
    Yunfeng Lin
    Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu
    J Cell Mol Med 9:929-39. 2005
    ..determine molecular and cellular characterization of PLA cells during chondrogenic differentiation in vitro and cartilage formation in vivo...
  100. pmc The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005
    The long-term integrity of an articulating joint is dependent upon the nourishment of its cartilage component and the protection of the cartilage surface from friction-induced wear...
  101. doi Magnetization transfer contrast and T2 mapping in the evaluation of cartilage repair tissue with 3T MRI
    Goetz H Welsch
    MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria
    J Magn Reson Imaging 28:979-86. 2008
    To use magnetization transfer (MT) imaging in the visualization of healthy articular cartilage and cartilage repair tissue after different cartilage repair procedures, and to assess global as well as zonal values and compare the results ..

Research Grants79

  1. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
    ..spondyloarthritis (PGISpA), which develops in genetically homogeneous inbred BALB/c mice upon immunization with cartilage PG, is permissive to genetic manipulation...
  2. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is associated with muscle strength decline, cartilage breakdown and pain-related disability...
  3. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..The outcome of my postdoctoral work is a proposed model depicting the hematopoietic niche in the cartilage-bone junction, which I will test further in this K01 award...
  4. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010 the technology is applied to additional problems in the healing of bone and other connective tissues, such as cartilage, meniscus, ligament and tendon...
  5. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    ..mesenchymal cells to proliferate and differentiate into the chondrocytes and osteoblasts that elaborate cartilage and bone...
    Tibor T Glant; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systemic immunization of BALB/c mice with human cartilage proteoglycan (PG) aggrecan induces progressive polyarthritis...
  7. Novel Collagen II Alternative Transcripts and Mouse Skeletal Development
    Audrey McAlinden; Fiscal Year: 2010
    ..We hypothesize that the IIC splicing event is an essential mechanism required for proper formation of cartilage (and possibly other tissues) during embryonic development...
  8. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..The expected significances of this pilot study of heat shock effects on hMSC differentiation into bone and cartilage cells are: (a) to facilitate hMSC proliferation and differentiation into osteoblasts/chondrocytes;(b) to improve ..
  9. The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide Receptors
    GARY ANDREW WEISMAN; Fiscal Year: 2013
    ..has been made in strategies for the regeneration of a variety of tissues including skin, corneal epithelium, cartilage, bone and bladder...
  10. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
    ..learned to allow for the production of alternatively spliced CaRs that are in fact expressed in bone, marrow, cartilage, skin and other cells...
  11. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..of tumor-like transformation including anchorage-independent growth, adhesion to the extracellular matrix of cartilage, resistance to apoptotic signaling, and invasiveness to cartilage and bone...
  12. A Cis-regulatory Model for Neural Border Induction
    Daniel Meulemans Medeiros; Fiscal Year: 2013
    ..migrate from this neural border domain to form diverse derivatives throughout the embryo, including bones and cartilage in the head, and portions of the cranial ganglia and heart...
  13. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2012
    ..nervous system and migrate over long distances to give rise to such cell types as sensory neurons, facial cartilage and pigment cells of the skin...
  14. Body composition, bone structure, and joint damage in rheumatoid arthritis
    Joshua F Baker; Fiscal Year: 2013
    ..bone may be important for prevention of invasion of inflammatory pannus, and integral to the health of overlying cartilage. Interventions to reverse lean mass deficits in RA could therefore have a valuable impact on disease outcomes ..
  15. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..The levels of these biomarkers in urine track with the extent of cartilage damage in patients...
  16. Thrombospondin 4 A1
    JOHN W LAWLER; Fiscal Year: 2010
    A detailed comprehension of the role of the thrombospondins (TSPs), including cartilage oligomeric matrix protein (COMP), in the regulation of extracellular matrix (ECM) structure and cellular behavior during tissue genesis and repair is ..
  17. Ribosomal Protein Gene Silencing in Neural Crest Stem Cells
    JOHNSON MING YU LIU; Fiscal Year: 2010
    ..HEALTH RELEVANCE: The neural crest is a specialized population of stem cells that generates most of the bone, cartilage, connective and peripheral nerve tissue in the head in the developing embryo, and abnormalities in the neural ..
  18. Identification of Mechanoresponsive Promoter Elements in Chondrogenesis
    Dominik R Haudenschild; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cartilage is constantly subjected to mechanical forces including compression, tension, and shear...
  19. The Role of FKBP10 in Recessive Osteogenesis Imperfecta
    Caressa Lietman; Fiscal Year: 2013
    ..of collagen are altered, in particular by the complex of proteins consisting of Prolyl-3-Hydroxylase-1 (P3H1), Cartilage Associated Protein (CRTAP) and prolyl cis-trans isomerase cyclophilin-B (PPIB) [6]...
  20. Elucidating the JNK2-mediated redox regulation of cartilage matrix remdeling
    ..Elevated levels of reactive oxygen species (ROS) have been observed in the cartilage of OA patients and may play a role in the stimulation of articular cartilage extracellular matrix (ECM) ..
  21. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    ..Biomechanical factors play an important role in the normal homeostatic maintenance of the cartilage extracellular matrix by chondrocytes, and under abnormal conditions, mechanical stress may be a significant ..
  22. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..long-term goal of this study is to understand the pathogenesis of osteoarthritis (OA)-like changes in articular cartilage that are associated with osteochondrodysplasias caused by mutations in extracellular matrix proteins...
  23. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..OA is manifested by degeneration in articular cartilage (initially decreased proteoglycan content, followed by reduced thickness) and damage to subchondral bone (..
  24. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2013
    ..nervous system and migrate over long distances to give rise to such cell types as sensory neurons, facial cartilage and pigment cells of the skin...
    Tariq M Haqqi; Fiscal Year: 2010
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
    Licia Selleri; Fiscal Year: 2009
    ..Finally, the cartilage primordium of the petrous part of the temporal bone is absent, leaving a hollow space (therefore this line will ..
  27. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010 which activated synovial fibroblasts produce chemokines that facilitate the invasion of the articular cartilage and underlying bone by the release of matrix-degrading enzymes...
  28. Calcification and Vascular Cell Differentiation
    Cecilia M Giachelli; Fiscal Year: 2013 de novo expression of Runx2 (also known as Cbfa1), a transcription factor required for normal bone and cartilage development. Furthermore, Erk1/2 signaling was required for SMC osteochondrocytic phenotype change in vitro...
  29. Suppression of Collagen Induced Arthritis with Altered Peptide Ligands
    Andrew H Kang; Fiscal Year: 2010 chronic synovitis, sustained by an antigen-driven immune process against one or more proteins found in cartilage. Although several antigens have been proposed to be involved in the autoimmune response in RA, type II collagen (..
  30. Identification of the transcriptional regulators of chondrocyte hypertrophy
    ANDREW BRUCE LASSAR; Fiscal Year: 2013
    ..the hope that this knowledge will lead to the development of reagents that could block this program in articular cartilage and thereby slow the progression of osteoarthritis...
    Tariq M Haqqi; Fiscal Year: 2011
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  32. A Developmental Craniofacial Atlas for the Zebrafish
    Charles B Kimmel; Fiscal Year: 2010
    ..cells making the skeleton will be revealed specifically by expression of markers including sox10 and foxp2a for cartilage, and osterix for bone...
  33. Obesity, Biomechanics, and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2013
    ..mechanical loading following injury to promote a state of inflammation and matrix degradation in the articular cartilage. We will pursue the following aims: In Aim 1, we will examine the role of a high-fat lard- based diet in the ..
  34. Effect of Smoking on Adult Stem Cell Differentiation
    Herman S Cheung; Fiscal Year: 2013
    ..Based on our institutional strengths on cellular therapies on cardiovascular diseases, cartilage and bone repair, Specific Aim 2a: We shall compare the viability of stem cells and their regenerative potential ..
  35. Genetic Regulation of Rhombomere Formation
    CHARLES G SAGERSTROM; Fiscal Year: 2013 many essential structures - sensory ganglia and branchiomotor neurons of the nervous system, as well as bone, cartilage and muscle of the head. The developing hindbrain is sensitive to disruptions by a variety of factors (e.g...
  36. The Toll-like receptor pathway in Meniscal Injury and Osteoarthritis
    CARLA ROSE SCANZELLO; Fiscal Year: 2013
    ..Scanzello to gain further training in specific laboratory techniques used in the fields of both Immunology and Cartilage Biochemistry, in order to gain full independence as an investigator...
  37. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013
    ..The impacts that occur during such activities may exceed the level that can be tolerated by cartilage pads between joints which cushion the moderate impacts accompanying mundane activities such as walking...
  38. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2010
    ..most of the peripheral nervous system (neurons and glia), as well as most of the skull and face, including cartilage, bone, and smooth muscle...
  39. BMP2 signaling of the development of osetoarthritis
    Vicki Rosen; Fiscal Year: 2013
    ..must be sorted out in order to determine the importance of changing levels of BMP2 signaling in articular cartilage in the pathogenesis of OA...
  40. Central Nervous System Mechanisms in Knee Osteoarthritis (KOA)
    Daniel J Clauw; Fiscal Year: 2013
    ..Historically, the "disease" of OA is viewed primarily as damage to the cartilage and bone. As such, the magnitude of damage or inflammation of these structures should predict symptoms...
  41. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..The quantitative MRI (qMRI) technique of T2 mapping developed for articular cartilage imaging is unable to capture the very short T2 values of the meniscus...
  42. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ..the large number of injury cases that exhibit bone bruises, or occult bone microcracks, and injury to overlying cartilage that occurs following injury- producing jump landings that often initiate the chronic disease process...
  43. High Throughput Screen for Novel Anti-Rheumatic Compounds
    Dale J Christensen; Fiscal Year: 2010
    ..COG133's efficacy at reducing swelling, clinical scores, and cartilage damage in the paws of treated mice, coupled with COG133-mediated lowering of cytokine and MMP production from ..
  44. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2012 osteoarthritis, chronically induced by abnormalities in mechanical loading or how it is transferred to the cartilage. Through multiscale mechanical coupling of these models, a map of cellular deformation in cartilage, ligaments ..
  45. Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &Biomechanics
    Marie Demay; Fiscal Year: 2013
    ..decreased long bone growth, accompanied by expansion of the hypertrophic chondrocyte layer and retention of cartilage in cortical bone. The studies in this proposal will examine the effects of bisphosphonates on growing bone...
  46. ROS activation of Apoptosis Signal-regulated Kinase1 (Ask1) in chondrocytes
    Theresa Freeman; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): In cartilage, reactive oxygen species (ROS) signaling plays significant role in regulating chondrocyte proliferation, differentiation and maturation...
  47. Regulation and Function of hTERT in Human Cells
    William C Hahn; Fiscal Year: 2013
    ..RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome Cartilage-Hair Hypoplasia. TERT and RMRP form an RNA dependent RNA polymerase (RdRP)...
  48. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2012
    ..Congenital defects, disease and trauma to synovial joints, in particular to the articular cartilage that comprises a joint, are debilitating o billions of people...
  49. Stem/progenitor cells of the chondrocyte and osteoblast lineage in vivo
    Noriaki Ono; Fiscal Year: 2013
    ..Specific Aim 1. Stem-like chondrocytes at the top of the postnatal epiphyseal growth plate cartilage: In endochondral bone formation, chondrocytes in the specific regions termed growth plates continue to ..
  50. Technology platform for development of multi-component preservation solution
    Allison Hubel; Fiscal Year: 2013
    ..treatment of cardiovascular disorders (stroke, myocardial infarction), diabetes, connective tissue disorders (cartilage defects, osteonecrosis, limb ischemia), chronic obstructive pulmonary disease, nervous system disorders (..
  51. Function and Regulation of CD-RAP
    Linda J Sandell; Fiscal Year: 2013
    ..The disease process is characterized by the aberrant gene expression and the inability of cartilage chondrocytes to repair the extracellular matrix leading to cartilage degeneration...
  52. Regulatory architecture of the Androgen Receptor locus in development & evolution
    Philip L Reno; Fiscal Year: 2010
    ..critical for the development of the sexually dimorphic phenotypes in many different mammalian tissues, including cartilage, bone, muscle, fat, skin, and secretory glands...
  53. The Role of MicroRNA in Rheumatoid Arthritis Pathogenesis
    Hiroshi Asahara; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and cartilage and bone destruction...
  54. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ..Following whole knee joint transplants in a rabbit model, mechanical properties of joint cartilage and kinematic analysis of joint function will be correlated with measures of blood flow, angiogenesis and ..
  55. Gene enhanced cartilage repair in a cytokine permissive environment
    Alan J Nixon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cartilage injuries and arthritis remain an unresolved cause of pain, debility, and diminished quality of life...
  56. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..These cells have potential to be used for un-related donors to treat diseases related to cartilage, bone, muscle or tendons/ligaments...
  57. Phase-contrast X-ray imaging system for large joints
    Dan Stutman; Fiscal Year: 2012
    ..has a strong contrast enhancing effect for joint tissue boundaries and for micro-structured tissues such as cartilage, tendon, ligament or muscle, enabling in the synchrotron experiments to image with high resolution soft tissues ..
  58. Molecular Basis of the Anti-inflammatory Action of MAYP/PSTPIP2
    Violeta Chitu; Fiscal Year: 2012
    ..expression, lead to a psoriatic arthritis-like autoinflammatory disease characterized by ear and paw necrosis, cartilage and bone destruction, indicating that MAYP has an anti-inflammatory activity...
  59. Phase-contrast enhanced X-ray imaging system for small joints of hand
    Thomas J Beck; Fiscal Year: 2010
    ..experiments using synchrotron X-rays demonstrate that DPC can image with high resolution soft tissues such as cartilage and ligaments in the joints of the hand, knee and ankle...
    CHRISTY LESLIE LUDLOW; Fiscal Year: 2012
    ..This device provides a noninvasive vibratory stimulus to the neck with motors placed on each side of the thyroid cartilage. The vibration to the cartilage penetrates through the tissues to stimulate sensory receptors in the larynx -..
  61. GE Healthcare Discovery MR750 3T MRI System
    FRANK KOROSEC; Fiscal Year: 2010 imaging, hyperpolarized gas imaging, high spatial resolution breast imaging, high spatial resolution cartilage degradation biomarker imaging, MRI-guided therapy, radiofrequency (RF) transmit/receive coil development, ..
  62. Establishment of Marmoset iPS-derived Cranial Neural Crest Cells
    Steven Farnsworth; Fiscal Year: 2013
    ..cells that during vertebrate development give rise to cranial Schwann cells, peripheral neurons, facial bone, cartilage, and the dental mesenchyme required in tooth genesis...
  63. Sp7 Mediated Control of Runx2 Function for Osteoblast Differentiation
    Amjad Javed; Fiscal Year: 2013
    ..Knowledge obtained from this study will provide molecular insights into components of bone regulatory complex that can be targeted for innovative therapy to improve cartilage and bone formation and repair.
  64. Role of BH3-domain proteins in the effector phase of RA
    HARRIS R PERLMAN; Fiscal Year: 2012 an autoimmune disease characterized by hyperplasia of the synovial lining, inflammation, and destruction of cartilage and bone...
  65. Perlecan modulates VEGF Bio-Availability in Human Osteoarthritic Cartilage
    RONALD GOMES; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how human articular cartilage derived heparan sulfate proteoglycans bind to and modulate the activity of heparin binding growth factors important for ..
    SHERRILL ADAMS; Fiscal Year: 1993
    Type III collagen is found in most connective tissues, but is not found in hyaline cartilage. However, a unique, previously undescribed RNA species has been detected in chick cartilage...
  67. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The cellular repair response to damaged articular cartilage that has been characterized by traditional light microscopic technology suggests reactivation of the same chondrocyte lineage that ..
  68. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    ..During the early stages of osteoarthritis, localized lesioning of the articular cartilage layer is a characteristic occurrence...
    Kenneth Brandt; Fiscal Year: 2003
    ..Notablly, however, several drugs have been shown to prevent, or slow progression of, cartilage damage in animal models of 0A, and drugs are currently being developed to inhibit protease-induced cartilage ..
    Robert Sah; Fiscal Year: 1999
    DESCRIPTION: (Adapted from investigator's abstract) Integrative repair of articular cartilage, defined as the healing of cartilage-cartilage or cartilage-tissue interfaces, is required in a number of orthopaedic conditions and rheumatic ..
  71. Self Assembly of Cartilage by Mesenchymal Stem Cells on Porous Chitosan/CaP
    STEVEN HOWARD ELDER; Fiscal Year: 2010
    ..The objective of this research is to begin developing a method for total joint resurfacing with engineered cartilage. The approach is based on generating a biphasic construct of porous chitosan/calcium phosphate and hyaline ..
  72. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance R Chu; Fiscal Year: 2010
    ..New clinical strategies to improve evaluation, repair, and regeneration of damaged articular cartilage are needed to prevent or delay the onset of disabling pain and OA...
  73. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..goal of this application is to better understand how proliferation and growth at the mandibular condylar cartilage (MCC) is regulated and if it is different from growth in the primary cartilage (growth plate) of limbs...
  74. A Standard Animal Model for Articular Cartilage Repair
    Anthony Ratcliffe; Fiscal Year: 2010
    ..problem, and joint replacement is generally regarded as appropriate only for the older patient with advanced cartilage loss. For the younger patient, the treatment modalities have significant limitations...
    Virginia Kraus; Fiscal Year: 2002
    ..OA) is a degenerative process in joints characterized by functional deterioration, abrasion of articular cartilage and formation of new bone at and around joint surfaces...
    Zhengmin Huang; Fiscal Year: 2007
    b>Cartilage development plays a pivotal role in embryonic skeletal pattern formation, endochondral bone formation and skeletal joint development...
  77. Specialized Centers for Cell-Based Therapy for NHLBI an*
    Shelly Carter; Fiscal Year: 2009
    ..This includes treatments using cellular-based therapies in oncology, hematologic diseases, cartilage repair, diabetes, and initial work in cardiac and vascular repair...
  78. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2005
    Degeneration of articular cartilage occurs with aging and accelerated in osteoarthritis (OA). However, the mechanisms responsible for these changes are currently unknown...
  79. Chondrogenic composite grafts for the repair of cartilage defects
    Jie Song; Fiscal Year: 2010
    ..provided by applicant): Traumatic injuries and age-related degenerative diseases associated with articular cartilage (AC) can result in significant patient morbidity and lead to the development of osteoarthritis...