tears

Summary

Summary: The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.

Top Publications

  1. ncbi Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca
    S C Pflugfelder
    Ocular Surface and Tear Center Bascom Palmer Eye Institute University of Miami School of Medicine Department of Ophthalmology Miami, FL 33136, USA
    Curr Eye Res 19:201-11. 1999
  2. ncbi Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface
    Lihui Luo
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 45:4293-301. 2004
  3. ncbi Preservatives in eyedrops: the good, the bad and the ugly
    Christophe Baudouin
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, INSERM, U968, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, CNRS, UMR_7210, Paris F 75012, France
    Prog Retin Eye Res 29:312-34. 2010
  4. ncbi Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarrays
    Nils Boehm
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:7725-30. 2011
  5. pmc HSV-1 DNA in tears and saliva of normal adults
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 46:241-7. 2005
  6. ncbi A mouse model of keratoconjunctivitis sicca
    Dilek Dursun
    Ocular Surface and Tear Center, Bascom Palmer Eye Institute, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 43:632-8. 2002
  7. pmc Changes to tear cytokines of type 2 diabetic patients with or without retinopathy
    Jingfang Liu
    First Hospital Affiliated to Medical College, Xi an Jiaotong University, Xi an, China
    Mol Vis 16:2931-8. 2010
  8. ncbi Efficacy of commercially available topical cyclosporine A 0.05% in the treatment of meibomian gland dysfunction
    Henry D Perry
    Ophthalmic Consultants of Long Island, Rockville Centre, New York 11570, USA
    Cornea 25:171-5. 2006
  9. ncbi Clinical performance of a mid-viscosity artificial tear for dry eye treatment
    Peter A Simmons
    Eye Care Research and Development, Allergan LLC, Irvine, CA 92612, USA
    Cornea 26:294-302. 2007
  10. ncbi The controlled-environment chamber: a new mouse model of dry eye
    Stefano Barabino
    Laboratory of Immunology, Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:2766-71. 2005

Detail Information

Publications301 found, 100 shown here

  1. ncbi Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca
    S C Pflugfelder
    Ocular Surface and Tear Center Bascom Palmer Eye Institute University of Miami School of Medicine Department of Ophthalmology Miami, FL 33136, USA
    Curr Eye Res 19:201-11. 1999
    ..To compare epidermal growth factor (EGF) concentration in tear fluid and levels of inflammatory cytokines in the conjunctival epithelium of patients with Sjögren's syndrome keratoconjunctivitis sicca with those of normal controls...
  2. ncbi Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface
    Lihui Luo
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 45:4293-301. 2004
    ....
  3. ncbi Preservatives in eyedrops: the good, the bad and the ugly
    Christophe Baudouin
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, INSERM, U968, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, CNRS, UMR_7210, Paris F 75012, France
    Prog Retin Eye Res 29:312-34. 2010
    ..Indeed, mild symptoms should not be underestimated, neglected, or denied, because they may very well be the apparent manifestations of more severe, potentially threatening subclinical reactions that may later cause major concerns...
  4. ncbi Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarrays
    Nils Boehm
    Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Invest Ophthalmol Vis Sci 52:7725-30. 2011
    ..However, the exact details of the pathomechanisms are still unknown. In this study, the expression patterns of proinflammatory cytokines in the tears of patients with different subtypes of dry eye were analyzed.
  5. pmc HSV-1 DNA in tears and saliva of normal adults
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 46:241-7. 2005
    To assess the frequency of shedding of herpes simplex virus type 1 (HSV-1) DNA in tears and saliva of asymptomatic individuals.
  6. ncbi A mouse model of keratoconjunctivitis sicca
    Dilek Dursun
    Ocular Surface and Tear Center, Bascom Palmer Eye Institute, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 43:632-8. 2002
    ....
  7. pmc Changes to tear cytokines of type 2 diabetic patients with or without retinopathy
    Jingfang Liu
    First Hospital Affiliated to Medical College, Xi an Jiaotong University, Xi an, China
    Mol Vis 16:2931-8. 2010
    To investigate changes in cytokine levels in tears of type 2 diabetics with or without retinopathy.
  8. ncbi Efficacy of commercially available topical cyclosporine A 0.05% in the treatment of meibomian gland dysfunction
    Henry D Perry
    Ophthalmic Consultants of Long Island, Rockville Centre, New York 11570, USA
    Cornea 25:171-5. 2006
    ..To investigate the efficacy of topical cyclosporine A 0.05% (tCsA) (Restasis, Allergan Pharmaceuticals) in the treatment of meibomian gland dysfunction (posterior blepharitis)...
  9. ncbi Clinical performance of a mid-viscosity artificial tear for dry eye treatment
    Peter A Simmons
    Eye Care Research and Development, Allergan LLC, Irvine, CA 92612, USA
    Cornea 26:294-302. 2007
    We report the results of 3 studies conducted to evaluate the performance of a 1.0% carboxymethylcellulose (CMC) mid-viscosity artificial tear compared to currently marketed low-viscosity tears.
  10. ncbi The controlled-environment chamber: a new mouse model of dry eye
    Stefano Barabino
    Laboratory of Immunology, Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:2766-71. 2005
    ..To develop a controlled-environment chamber (CEC) for mice and verify the effects of a low-humidity setting on ocular surface signs in normal mice...
  11. pmc A method to extract cytokines and matrix metalloproteinases from Schirmer strips and analyze using Luminex
    Karl R VanDerMeid
    Pharmaceutical R and D, Bausch Lomb, Inc, Rochester, NY 14609, USA
    Mol Vis 17:1056-63. 2011
    ..This report describes a procedure which can be used to recover tears from the Schirmer strip for the measurement of multiple tear cytokines as well as matrix metalloproteinases (MMPs) ..
  12. ncbi Increased evaporative rates in laboratory testing conditions simulating airplane cabin relative humidity: an important factor for dry eye syndrome
    Eduardo Uchiyama
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:174-6. 2007
    ....
  13. pmc Repeated measurements of dynamic tear distribution on the ocular surface after instillation of artificial tears
    Jianhua Wang
    Department of Ophthalmology, University of Rochester, NY 14642, USA
    Invest Ophthalmol Vis Sci 47:3325-9. 2006
    ..To determine the repeatability of real-time optical coherence tomography (OCT) measurements of tear film thickness (TFT) and variables of tear film menisci...
  14. ncbi Cytokine and chemokine levels in tears from healthy subjects
    Ester Carreño
    Instituto Universitario de Oftalmobiología, University of Valladolid, Spain
    Acta Ophthalmol 88:e250-8. 2010
    There is growing evidence for the existence of an 'immune tone' in normal tears. The aim of this study was to determine the levels of a large panel of cytokines and chemokines in tears obtained from healthy subjects...
  15. ncbi Assessing the severity of keratitis sicca with videokeratoscopic indices
    Cintia Sade de Paiva
    Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    Ophthalmology 110:1102-9. 2003
    ..To determine the correlation between the regularity indices of the Tomey TMS-2N computerized videokeratoscopy (CVK) instrument (Tomey, Waltham, MA) with conventional measures of dry eye symptoms and disease...
  16. pmc Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome
    Suksri Chotikavanich
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 50:3203-9. 2009
    ..To evaluate production and activity of metalloproteinase (MMP)-9 on the ocular surface of patients with dysfunctional tear syndrome (DTS) and determine any correlation between MMP-9 activity and clinical parameters...
  17. pmc Investigation of the human tear film proteome using multiple proteomic approaches
    Kari B Green-Church
    Mass Spectrometry and Proteomics Facility, The Ohio State University, Columbus, OH 43210, USA
    Mol Vis 14:456-70. 2008
    ....
  18. pmc Resolvin E1 improves tear production and decreases inflammation in a dry eye mouse model
    Na Li
    Neuroscience Center of Excellence and the Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Ocul Pharmacol Ther 26:431-9. 2010
    ..Here we investigated the role of RvE1 in a DE mouse model...
  19. ncbi Allergic conjunctivitis: update on pathophysiology and prospects for future treatment
    Santa Jeremy Ono
    Department of Immunology, University College London, Institutes of Ophthalmology and Child Health and Moorfields Eye Hospital, NHS Trust, United Kingdom
    J Allergy Clin Immunol 115:118-22. 2005
    ....
  20. ncbi Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model
    T Fujihara
    Santen Pharmaceutical Co, Ltd, Nara Research and Development Center, Japan
    Invest Ophthalmol Vis Sci 42:96-100. 2001
    ..Accordingly, the effects of such an agonist INS365 on these parameters were characterized in a rat dry eye model...
  21. pmc Tear cytokine profiles in dysfunctional tear syndrome
    Helene Lam
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA
    Am J Ophthalmol 147:198-205. e1. 2009
    ..To compare tear cytokine and chemokine concentrations in asymptomatic control and Dysfunctional Tear syndrome (DTS) patients and determine the correlations between tear inflammatory mediators and clinical severity...
  22. ncbi [A new approach for better comprehension of diseases of the ocular surface]
    C Baudouin
    Centre National d Ophtalmologie des Quinze Vingts, Paris, France
    J Fr Ophtalmol 30:239-46. 2007
    ....
  23. ncbi A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance
    Stephen C Pflugfelder
    Baylor College of Medicine, Houston, Texas, USA
    Am J Ophthalmol 138:444-57. 2004
    ..To evaluate loteprednol etabonate ophthalmic 0.5% suspension, versus placebo for treatment of the inflammatory component of keratoconjunctivitis sicca in patients with delayed tear clearance...
  24. ncbi Diagnostic potential of tear proteomic patterns in Sjögren's syndrome
    Naohisa Tomosugi
    Division of Nephrology, Department of Internal Medicine, Knanazawa Medical University, 920 0265 Ishikawa, Japan
    J Proteome Res 4:820-5. 2005
    ..These findings support the potential of proteomic pattern technology in tear fluids as the noninvasive diagnostic test for primary SS...
  25. ncbi SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye
    Franz H Grus
    Department of Ophthalmology, Universitaets Augenklinik, Langenbeckstrasse 1, 55101 Mainz, Germany
    Invest Ophthalmol Vis Sci 46:863-76. 2005
    Protein and peptides in tears play an important role in ocular surface diseases. In previous studies, changes have been demonstrated in the electrophoretic protein profiles of patients with dry eye...
  26. ncbi Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice
    Takashi Kojima
    Department of Ocular Surface and Visual Optics, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 180:1879-96. 2012
    ..of secretory vesicles in acinar epithelial cells, decreased production of both stimulated and nonstimulated tears, and a decline in total protein secretion from the lacrimal glands...
  27. ncbi Sensitivity and specificity of a point-of-care matrix metalloproteinase 9 immunoassay for diagnosing inflammation related to dry eye
    Robert Sambursky
    Manatee Sarasota Eye Clinic and Laser Center, Sarasota, Bradenton, FL 34202, USA
    JAMA Ophthalmol 131:24-8. 2013
    ..To determine the clinical sensitivity, specificity, negative predictive value, and positive predictive value of a rapid point-of-care diagnostic test to detect elevated matrix metalloproteinase 9 levels (InflammaDry)...
  28. ncbi The impact of contact lens wear and visual display terminal work on ocular surface and tear functions in office workers
    Takashi Kojima
    Johnson and Johnson Ocular Surface and Visual Optics Department, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 152:933-940.e2. 2011
    ..To evaluate the effect of contact lens (CL) wear and visual display terminal (VDT) work on the ocular surface and tear functions...
  29. ncbi Comparative proteomics of human male and female tears by two-dimensional electrophoresis
    Sivagnanam Ananthi
    Dr G Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Aravind Eye Care System, Madurai, India
    Exp Eye Res 92:454-63. 2011
    ..Mostly, the up regulated proteins are involved in the local immune defense; implying that there may be a sex difference in the ability to defend against infection at the anterior segment of the eyes of normal individuals...
  30. pmc A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and saliva
    Manish Kumar
    Department of Ophthalmology, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Invest Ophthalmol Vis Sci 50:5601-8. 2009
    To test the effect of valacyclovir alone and with aspirin on the asymptomatic shedding of HSV-1 DNA in tears and saliva of healthy individuals. METHOD...
  31. ncbi Tear production and corneal sensitivity in diabetes
    Pippa Cousen
    Princess Alexandra Eye Pavilion, Edinburgh, UK
    J Diabetes Complications 21:371-3. 2007
    ..The aim of this study was to investigate whether diabetes mellitus is correlated with both reduced corneal sensation and reduced tear production...
  32. ncbi In vitro and in vivo effects of a lubricant in a contact lens solution
    Lee C Thai
    Department of Vision Sciences, Glasgow Caledonian University, UK
    Ophthalmic Physiol Opt 22:319-29. 2002
    ..Physical properties and tear film function were investigated for a multipurpose contact lens solution containing the ocular lubricant hydroxypropyl methylcellulose (HPMC)...
  33. ncbi Two dimensional electrophoretic analysis of human tears: collection method in dry eye syndrome
    Aluru Venkata Saijyothi
    Biochemistry and Cell Biology Department, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Electrophoresis 31:3420-7. 2010
    ..Schirmer method of tear collection is reliable in patients with dry eye, which can display the differential protein expression and help in biomarker identification...
  34. ncbi Tear cytokines and chemokines in patients with Demodex blepharitis
    Jee Taek Kim
    Department of Ophthalmology, College of Medicine, Chung Ang University, Yongsan Hospital, 65 207, Hangangro 3Ga, Yongsan gu, Seoul 140 757, Republic of Korea
    Cytokine 53:94-9. 2011
    ..The purpose of the study is to evaluate the causes of inflammation in Demodex-induced blepharitis by analyzing cytokine levels in lacrimal fluid...
  35. ncbi Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease
    Kyung Sun Na
    Department of Health Promotion Center, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Invest Ophthalmol Vis Sci 53:5443-50. 2012
    To determine cytokine and chemokine concentrations in the tears of patients with dry eye disease (DED) and analyze the possible relationships with the clinical severity of DED.
  36. ncbi Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study
    Michael A Lemp
    Department of Ophthalmology, Georgetown University, Washington, DC, USA
    Cornea 31:472-8. 2012
    ..To evaluate in a general clinic-based cohort of patients with dry eye disease (DED) the distribution of patients with aqueous-deficient or evaporative subtype of DED...
  37. ncbi [Dry eye disease as a complex dysregulation of the functional anatomy of the ocular surface. New concepts for understanding dry eye disease]
    E Knop
    Augenklinik Forschungslabor, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum
    Ophthalmologe 100:917-28. 2003
    ..Dry eye disease is a disorder of the tear film that results in epithelial damage and in a disruption of the normal homeostasis at the ocular surface. It is widespread and causes symptoms ranging from discomfort to blindness...
  38. ncbi Mucins and ocular signs in symptomatic and asymptomatic contact lens wear
    Monica Berry
    University of Bristol, Academic Unit of Ophthalmology, Bristol, United Kingdom
    Optom Vis Sci 85:E930-8. 2008
    ..As the mucus layer is a protector of the ocular surface tissue, this study investigates whether any alterations of mucins are detectable comparing symptomatic and asymptomatic soft contact lens wearers...
  39. ncbi Tear analysis and lens-tear interactions. Part I. Protein fingerprinting with microfluidic technology
    Aisling M Mann
    Biomaterials Research Unit, School of Engineering and Applied Science, Aston University, Birmingham, B4 7ET, UK
    Cont Lens Anterior Eye 30:163-73. 2007
    ..Furthermore, whilst lens-tear interaction studies are generally thought of as an investigation into the effects of tears components on the contact lens material, i.e...
  40. ncbi Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis
    Andrea Leonardi
    Department of Ophthalmology, University of Padua, via Foscari 8, 35127 Padua, Italy
    Ophthalmology 110:487-92. 2003
    ..The purpose of this study was to measure these chemokines in tear and mucus samples of active-disease patients and in vitro cultured conjunctival epithelial cells and fibroblasts...
  41. ncbi Tear analysis in ocular surface diseases
    Lei Zhou
    Singapore Eye Research Institute, Singapore
    Prog Retin Eye Res 31:527-50. 2012
    The thin layer of tears covering the ocular surface are a complex body fluid containing thousands of molecules of varied form and function of several origins...
  42. ncbi Alternative reference values for tear film break up time in normal and dry eye populations
    Mark B Abelson
    Ophthalmic Research Associates, Dry Eye Department, North Andover, Massachusetts, USA
    Adv Exp Med Biol 506:1121-5. 2002
  43. ncbi Lactoferrin in Sjögren's syndrome
    Murat Dogru
    Ophthalmology 114:2366-7. 2007
  44. pmc Modulation of epithelial immunity by mucosal fluid
    James J Mun
    School of Optometry and Vision Science Program, University of California, Berkeley, CA 94720, USA
    Sci Rep 1:8. 2011
    ..While fluids bathing mucosal surfaces (e.g. tears) contain antimicrobials, potentially pathogenic microbes often thrive in these fluids, suggesting that additional ..
  45. ncbi Fluorophotometric measurement of the buffering action of human tears in vivo
    M Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Curr Eye Res 17:1005-9. 1998
    The buffering action of human tears is thought to be important to keep its pH constant. We measured the change in pH in the precorneal tear film in vivo when the acidic solution is challenged, using a fluorophotometric technique.
  46. ncbi Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea
    Andres Parra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, San Juan de Alicante, Spain
    Nat Med 16:1396-9. 2010
    ..Warming of the cornea in humans also decreases tearing rate. These findings indicate that TRPM8-dependent impulse activity in corneal cold receptors contributes to regulating basal tear flow...
  47. pmc Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated
    Sandeep Samudre
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Invest Ophthalmol Vis Sci 52:6265-70. 2011
    ..This study investigates whether lacritin is prosecretory when added topically to the ocular surface of normal living rabbits, and if so, what is its efficacy and tolerability versus cyclosporine and artificial tears.
  48. ncbi Factor XIII subunits in human tears; their highly elevated levels following penetrating keratoplasty
    Zsuzsanna Z Orosz
    Clinical Research Center, University of Debrecen, Medical and Health Science Center, 98 Nagyerdei krt, 4032 Debrecen, Hungary
    Clin Chim Acta 412:271-6. 2011
    ..high importance in wound healing, we determined the concentrations of FXIII A and B subunits (FXIII-A and FXIII-B) and their complex (FXIII-A(2)B(2)) in normal tears and in tears from patients undergoing penetrating keratoplasty (PKP).
  49. ncbi Human tears contain a chemosignal
    Shani Gelstein
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 331:226-30. 2011
    Emotional tearing is a poorly understood behavior that is considered uniquely human. In mice, tears serve as a chemosignal. We therefore hypothesized that human tears may similarly serve a chemosignaling function...
  50. ncbi Human tear lipocalin
    B Redl
    Institut fur Mikrobiologie, Medizinische Fakultat, Universitat Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Biochim Biophys Acta 1482:241-8. 2000
    ..It would be ideally suited for scavenging of lipophilic, potentially harmful substances and thus might act as a general protection factor of epithelia...
  51. ncbi Molecular and cellular biomarkers in dry eye disease and ocular allergy
    Amalia Enríquez-de-Salamanca
    IOBA Institute of Applied Ophthalmobiology, University of Valladolid, Valladolid, Spain
    Curr Opin Allergy Clin Immunol 12:523-33. 2012
    ..To summarize recent studies in biomarkers in dry eye disease (DED) and ocular allergy in the last 18 months...
  52. ncbi Decrease in tear secretion and corneal sensitivity after laser in situ keratomileusis
    J M Benitez-Del-Castillo
    Instituto de Investigaciones Oftalmologicas Ramon Castroviejo, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Cornea 20:30-2. 2001
    ..05). CONCLUSION: In the correction of myopia, tear secretion was depressed after LASIK during the first 6 months after surgery...
  53. ncbi Hypoxic effects on the anterior eye of high-Dk soft contact lens wearers are negligible
    M Covey
    The Cornea and Contact Lens Research Unit, School of Optometry and The Cooperative Research Centrefor Eye Research and Technology, University of New South Wales, Sydney, Australia
    Optom Vis Sci 78:95-9. 2001
    ..Conjunctival staining can generally distinguish lens wearers from non-lens wearers and can be used to discriminate between high-Dk lens wearing subjects and non-lens wearing subjects...
  54. ncbi Effect of experimental dry eye on tear sodium concentration in the mouse
    Paul Stewart
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA
    Eye Contact Lens 31:175-8. 2005
    ..To examine the changes in tear volume, sodium concentration, and osmolarity in BALB/c and C57BL/6J mice in response to experimental dry eye (EDE)...
  55. pmc MUC1 expression in Sjogren's syndrome, KCS, and control subjects
    Barbary Caffery
    Center for Contact Lens Research, School of Optometry, University of Waterloo, Ontario, Canada
    Mol Vis 16:1720-7. 2010
    To quantify and compare human mucin 1 (MUC1) protein and mRNA expression in tears and conjunctival epithelial cells collected from Sjogren's syndrome (SS), non-Sjogren's keratoconjunctivitus sicca (KCS) and non-dry eyed (NDE) control ..
  56. pmc Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease
    Amalia Enríquez-de-Salamanca
    Ocular Surface Group, IOBA University of Valladolid, Campus Miguel Delibes, Valladolid, Spain
    Mol Vis 16:862-73. 2010
    ..This study analyzes tear cytokine levels and their clinical correlations in patients with moderate evaporative-type DED due to meibomian gland disease (MGD)...
  57. ncbi Lipophilin, a novel heterodimeric protein of human tears
    R I Lehrer
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    FEBS Lett 432:163-7. 1998
    We identified a novel heterodimeric protein, lipophilin AC, in human tears. One of its components, lipophilin A (69 residues; mass, 7575.1; pI, 9...
  58. pmc Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbits
    Manish Kumar
    Department of Ophthalmology, Neuroscience Center of Excellence, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 51:4703-6. 2010
    To assess the effect of high doses of valacyclovir (VCV) on HSV-1 DNA shedding into tears of latently infected rabbits.
  59. ncbi Surface chemistry study of the interactions of benzalkonium chloride with films of meibum, corneal cells lipids, and whole tears
    Georgi A Georgiev
    Department of Biochemistry, Faculty of Biology, University of Sofia, Bulgaria
    Invest Ophthalmol Vis Sci 52:4645-54. 2011
    ..To perform a surface chemistry study of the interactions between benzalkonium chloride (BAC), a common preservative used in ophthalmic formulations, and tear film (TF) constituents...
  60. pmc Advanced glycation end product (AGE) modified proteins in tears of diabetic patients
    Zhenjun Zhao
    Brien Holden Vision Institute, Sydney, NSW 2052, Australia
    Mol Vis 16:1576-84. 2010
    ..This study investigated AGE modified proteins in tears and compared their levels in diabetic patients (DM) with non-diabetic controls (CTL).
  61. pmc Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis
    Marta Sacchetti
    Department of Ophthalmology, University of Rome Campus Bio Medico, Rome, Italy
    Mol Vis 17:47-52. 2011
    ..In this study, we aimed at evaluating the role of substance P (SP), calcitonine gene related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in allergic reactions of the ocular surface...
  62. ncbi Efficacy of topical cyclosporin 0.05% in the treatment of posterior blepharitis
    Michael Rubin
    Department of Ophthalmology, University of Chicago, Chicago, IL 60605, USA
    J Ocul Pharmacol Ther 22:47-53. 2006
    ..These findings should be further evaluated in large-scale, controlled, clinical trials...
  63. ncbi Therapeutic targets in dry eye syndrome
    Assumpta Peral
    Optics Department II Optometry and Vision, Escuela Universitaria de Optica, Madrid, Spain
    Drug News Perspect 21:166-76. 2008
    Dry eye is a multifactorial disease of the tears and the ocular surface that manifests with a wide variety of signs and symptoms. It is prevalent in about 33% of the population worldwide...
  64. ncbi A new model of experimental autoimmune keratoconjunctivitis sicca (KCS) induced in Lewis rat by the autoantigen Klk1b22
    Guomin Jiang
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 50:2245-54. 2009
    ..This study was designed to generate an inducible autoimmune model of keratoconjunctivitis sicca (KCS) for study of pathogenesis of the disease...
  65. ncbi The lack of association between signs and symptoms in patients with dry eye disease
    Kelly K Nichols
    College of Optometry, The Ohio State University, Columbus, OH 43218 2342, USA
    Cornea 23:762-70. 2004
    ..The purpose of this report was to examine the relation between clinical tests and dry eye symptoms in patients with dry eye disease...
  66. ncbi Analysis of inflammatory cytokines in the tears of dry eye patients
    Morgan L Massingale
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, USA
    Cornea 28:1023-7. 2009
    To determine the levels of 8 important cytokines and 1 chemokine in tears of patients with dry eye disease.
  67. ncbi Correlation between TGF-beta1 in tears and corneal haze following LASEK and epi-LASIK
    Qin Long
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academic of Medical Science, Medical College, Peking, China
    J Refract Surg 22:708-12. 2006
    ....
  68. pmc Proteomic analysis of the tear film in patients with keratoconus
    Isabel Lema
    Instituto Galego de Oftalmoloxia, Servizo Galego de Saúde, University of Santiago de Compostela, Santiago de Compostela, Spain
    Mol Vis 16:2055-61. 2010
    ..To identify proteins differentially expressed between the tear film of keratoconus (KC) patients and control subjects using two dimensional electrophoresis (2-DE) and mass spectrometry-based techniques...
  69. ncbi Advances in understanding and managing dry eye disease
    Michael A Lemp
    Department of Ophthalmology, Georgetown University School of Medicine, 4000 Cathedral Avenue NW, Washington, DC 20016, USA
    Am J Ophthalmol 146:350-356. 2008
    ....
  70. pmc Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice
    Cintia S de Paiva
    Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Rheumatology (Oxford) 49:246-58. 2010
    ..The objective of this study was to evaluate the severity of corneal epithelial disease and T-cell cytokine profile in the ocular surface tissues of CD25KO mice...
  71. pmc On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Invest Ophthalmol Vis Sci 49:3779-89. 2008
    To qualitatively compare the nonpolar lipids present in meibomian gland (MG) secretions (samples T1) with aqueous tears (AT) collected from the lower tear menisci of healthy, non-dry eye volunteers using either glass microcapillaries (..
  72. ncbi Significance of mucin on the ocular surface
    Hitoshi Watanabe
    Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Suita, Japan
    Cornea 21:S17-22. 2002
    ..To review the significance of mucin in the tear film and the ocular surface epithelium...
  73. ncbi Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics
    Lei Zhou
    Singapore Eye Research Institute, Singapore, Singapore
    J Proteome Res 8:4889-905. 2009
    The proteins found in tears have an important role in the maintenance of the ocular surface and changes in the quality and quantity of tear components reflect changes in the health of the ocular surface...
  74. ncbi Quantification of tear proteins by SDS-PAGE with an internal standard protein: a new method with special reference to small volume tears
    Kaijun Li
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, 510060, People s Republic of China
    Graefes Arch Clin Exp Ophthalmol 248:853-62. 2010
    ..The aim of this study was to efficiently quantify the tear proteins by SDS-PAGE with an internal standard protein in small tear volumes...
  75. pmc Understanding and analyzing meibomian lipids--a review
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Eye Res 33:405-20. 2008
    ..This review is intended to bring to the informed reader the current state of knowledge about meibomian lipids and the art for analyzing them...
  76. ncbi Identification and quantification of thymosin beta4 in human saliva and tears
    Mahnaz Badamchian
    Department of Biochemistry and Molecular Biology, The George Washington University, School of Medicine and Health Sciences, 2300 Eye Street, N W, Washington, DC 20037, USA
    Ann N Y Acad Sci 1112:458-65. 2007
    ..In this study, we sought to determine whether Tbeta(4) is naturally occurring in human tears and other human bodily fluids, such as saliva...
  77. ncbi Subclinical keratoconus and inflammatory molecules from tears
    I Lema
    Instituto Galego de Oftalmoloxia, University of Santiago de Compostela, Spain
    Br J Ophthalmol 93:820-4. 2009
    ..The purpose of this study was to determine the levels of proinflammatory cytokines and matrix metalloproteinase 9 (MMP-9) in tears from both eyes of unilateral keratoconus (KC) patients.
  78. ncbi The modern office environment desiccates the eyes?
    P Wolkoff
    Indoor Environment Group, National Institute of Occupational Health, Copenhagen, Denmark
    Indoor Air 16:258-65. 2006
    ..In addition, air temperature as well as certain alkene oxidation products by ozone may worsen eye irritation symptoms, but the latter factor may be smaller at higher relative humidity...
  79. ncbi Effect of artificial tears on visual acuity
    Mohammad Reza Nilforoushan
    Laser and Corneal Surgery Associates, PC, New York 10022, USA
    Am J Ophthalmol 140:830-5. 2005
    ..To study the effect of commonly used preservative free artificial tear, carboxymethylcellulose (CMC) 0.5% (Refresh Plus, Allergan, Irvine, California) on visual acuity in symptomatic dry eye (SDE) and asymptomatic dry eye (ADE) patients...
  80. pmc Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases
    Darlene A Dartt
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Prog Retin Eye Res 28:155-77. 2009
    ..This review focuses on the neural regulation of lacrimal gland secretion under normal and dry eye conditions...
  81. ncbi The Effect of instilled fluorescein solution volume on the values and repeatability of TBUT measurements
    Michael E Johnson
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Cornea 24:811-7. 2005
    ....
  82. ncbi Nanoscale phase dynamics of the normal tear film
    Santosh Khanal
    School of Natural Sciences, Parramatta Campus, University of Western Sydney, Penrith South DC, New South Wales, Australia
    Nanomedicine 6:707-13. 2010
    ..These data support the view of a distinct three-layered tear film: an inner mucin layer attached to the epithelial cells, a fluid aqueous layer, and an outer viscoelastic lipid layer...
  83. ncbi Ocular discomfort by environmental and personal risk factors altering the precorneal tear film
    Peder Wolkoff
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Toxicol Lett 199:203-12. 2010
    ....
  84. pmc Molecular organization of the tear fluid lipid layer
    Pipsa Kulovesi
    Department of Ophthalmology, University of Helsinki, Finland
    Biophys J 99:2559-67. 2010
    ..Similar type of behavior is observed in lung surfactant but the folding takes place toward the aqueous phase. The results provide novel information of the function of lipids in the tear fluid...
  85. pmc Tear proteomics in keratoconus
    Catherine Pannebaker
    College of Optometry, The Ohio State University, Columbus, OH 43210, USA
    Mol Vis 16:1949-57. 2010
    ..The purpose of this work was to identify potential tear-film based proteins expressed in keratoconus...
  86. ncbi Substance P released from sensory nerve endings influences tear secretion and goblet cell function in the rat
    Illes Kovacs
    Department of Pharmacology and Pharmacotherapy, Neuropharmacology Research Group of the Hungarian Academy of Sciences, University of Pecs, 12 Szigeti Str, Pecs, Hungary
    Neuropeptides 39:395-402. 2005
    ..Following unilateral electrical stimulation of the trigeminal ganglion, tears were collected at both sides and assessed for volume and protein concentration; as well as gel electrophoresis and ..
  87. pmc Quantification of tear proteins and sPLA2-IIa alteration in patients with allergic conjunctivitis
    Kaijun Li
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, China
    Mol Vis 16:2084-91. 2010
    ..the alteration of the major tear protein components and a lipid related protein secretory type IIa phospholipase A2 (sPLA2-IIa) in tears of seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) patients.
  88. pmc Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay
    Xiaofen Zheng
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
    Cornea 29:1048-54. 2010
    ..To develop a new bioassay method using human lung epithelial cells (CCL-185) to assess activity of transforming growth factor beta (TGF-beta) in human tear fluid from normal subjects and patients with dry eye...
  89. ncbi Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis
    E Nivenius
    Department of Clinical Neuroscience, Karolinska Institutet, Division of Ophthalmology, St Erik s Eye Hospital, Stockholm, Sweden
    Eye (Lond) 21:968-75. 2007
    ..Secondary aims were to compare the effects of the treatments on eyelid eczema and their potential impact on ocular surface inflammation...
  90. ncbi MUC5AC overexpression in tear film of neonates
    Flavio Mantelli
    Interdisciplinary Center for Biomedical Research Laboratory of Ophthalmology, Campus Bio Medico University of Rome, Rome, Italy
    Graefes Arch Clin Exp Ophthalmol 245:1377-81. 2007
    Full-term neonates produce tears normally, but neonatal tear film is modified to resist evaporation with a thick lipid layer that allows lower spontaneous blink rates...
  91. ncbi Daily rhythm of tear production in normal horse
    Giuseppe Piccione
    Dipartimento di Scienze Sperimentali e Biotecnologie Applicate, Laboratorio di Cronofisiologia Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Messina, Italy
    Vet Ophthalmol 11:57-60. 2008
    ..This study was designed to assess the daily rhythm of tear production in clinically healthy horses, to compare left eye and right eye, and to evaluate the influence of time and gender...
  92. ncbi Tear sample collection using cellulose acetate absorbent filters
    Marieh Esmaeelpour
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4LU, UK
    Ophthalmic Physiol Opt 28:577-83. 2008
    ..To assess the use of cellulose acetate filter rods as a technique for tear collection...
  93. ncbi Chitinase levels in the tears of subjects with ocular allergies
    Maria Musumeci
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cornea 27:168-73. 2008
    ..The role of AMCase in allergic ocular pathologies has never been studied previously...
  94. ncbi Atopy, symptoms and indoor environmental perceptions, tear film stability, nasal patency and lavage biomarkers in university staff
    Jan Vilhelm Bakke
    Section for Occupational Medicine, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, 5018 Bergen, Norway
    Int Arch Occup Environ Health 81:861-72. 2008
    ..Personal predictors (gender, age, smoking, infections) for the biomarkers as well as associations between the biomarkers were also assessed...
  95. ncbi Ocular surface and tear functions after topical cyclosporine treatment in dry eye patients with chronic graft-versus-host disease
    Y Wang
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Bone Marrow Transplant 41:293-302. 2008
    ..Bone Marrow Transplantation (2008) 41, 293-302; doi:10.1038/sj.bmt.1705900; published online 5 November 2007...
  96. ncbi Concentration of soluble interleukin-6 receptors in tears of allergic conjunctival disease patients
    Jun Shoji
    Department of Ophthalmology, Division of Visual Science, Nihon University School of Medicine, Itabashi, Tokyo, Japan
    Jpn J Ophthalmol 51:332-7. 2007
    To evaluate the significance of soluble interleukin-6 receptor (sIL-6R) in tears as a clinical indicator of disease exacerbation in patients with allergic conjunctivitis disease (ACD).
  97. ncbi Surface-enhanced Laser Desorption/Ionisation Time-of-flight Mass Spectrometry to Detect Breast Cancer Markers in Tears and Serum
    Antje Lebrecht
    Johannes Gutenberg University Mainz, Department of Obstetrics and Gynecology, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Cancer Genomics Proteomics 6:75-83. 2009
    ..New biomarkers are needed to improve the early detection of breast cancer. This study describes the use of surface-enhanced laser desorption/ionisation time-of-flight mass spectroscopy (SELDI-TOF-MS) in serum and tear fluid...
  98. ncbi Tearfilm immunoglobulin E (IgE) level in vernal keratoconjunctivitis by ELISA
    S Pokharel
    Ophthalmology Department, Kathmandu Medical College, Sinamangal, Nepal
    Kathmandu Univ Med J (KUMJ) 7:104-8. 2009
    ..Type I hypersensitivity reaction which is IgE-dependent and type IV hypersensitivity reaction have been implicated for the pathogenesis VKC...
  99. ncbi Tear proteomics in evaporative dry eye disease
    P Versura
    Ophthalmology Unit, University of Bologna, Bologna, Italy
    Eye (Lond) 24:1396-402. 2010
    ..To analyze tear protein variations in patients suffering from dry eye symptoms in the presence of tear film instability but without epithelial defects...

Research Grants72

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Blood samples will be collected. Other samples, such as saliva, tears, hair, stool, and urine, may be collected as needed. Adult participants may also provide a skin sample...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Blood samples will be collected. Other samples, such as saliva, tears, hair, stool, and urine, may be collected as needed. Adult participants may also provide a skin sample...
  3. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..to PMN, a specific Group IIA phospholipase A2 (GpIIA-PLA2), which is present in plasma of infected animals, tears, and inflammatory fluid, exhibits potent activity to kill and degrade SA...
  4. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..improved hepatic histology and loss of hepatic steatosis, and reduced thiobarbituric acid reactive substances (TEARS), a surrogate marker of oxidative stress...
  5. Abnormal Bladder Epithelial Cell Gene Expression in BPS/IC
    SUSAN F KEAY; Fiscal Year: 2013
    ..abnormalities are the most consistent findings in bladder biopsies from BPS/IC patients, including denudation, tears, or thinning of the epithelium, coupled with abnormal proteoglycan and protein expression (including tight ..
  6. Aligned Tendon or Ligament Derived Matrix Nanoscaffolds for Rotator Cuff Repair
    Dianne Little; Fiscal Year: 2013
    ..matrix (TLDM) patch for augmentation of rotator cuff repair or as a tendon substitute in irreparable rotator cuff tears while allowing the PI to establish an independent research career in tissue engineering of tendon and ligament...
  7. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..at meniscal repair should be made in order to preserve meniscus function and subsequent joint health since tears and disruption of the meniscus lead to degenerative osteoarthritis [2]...
  8. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene A Dartt; Fiscal Year: 2012
    ..The present proposal focuses on the lacrimal gland secretion of the aqueous layer of tears and its dysfunction that causes aqueous deficiency dry eye (ADDE)...
  9. Novel Early Intervention to Prevent Post-Traumatic Osteoarthritis
    Dominik R Haudenschild; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Joint injuries such as ACL ruptures or meniscal tears typically occur in a young athletic population...
  10. MICROTUBULE-BASED TRANSPORT IN LACRIMAL GLAND FUNCTION
    Sarah F Hamm-Alvarez; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The acinar cells of the lacrimal gland (LG) release proteins into tears that have nutrient, anti-infective and regulatory properties...
  11. PROOF OF CONCEPT FOR ANTIMICROBIAL PROPERTIES OF LACRITIN IN VIVO
    John D Sheppard; Fiscal Year: 2010
    ..an antimicrobial agent and that topical application of lacritin will augment the native antimicrobial activity in tears. As an ocular-specific presecretory glycoprotein, lacritin has a unique mechanism of action...
  12. Sex-specific movement differences in young adults with and without hip pain
    CARA L LEWIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acetabular labral tears are an increasingly recognized source of hip pain in young adults, especially females, and have been linked to the premature development of hip osteoarthritis (OA)...
  13. Image-based modeling of nonlinear and anisotropic intervertebral disc mechanics
    Edward J Vresilovic; Fiscal Year: 2010
    ..that calculate the disc internal stresses and strains are essential to investigate mechanisms of disc injuries, tears, and failure...
  14. Autoantibodies and B Cell Chemotaxis in Sjogren's Syndrome
    JILL MARIE KRAMER; Fiscal Year: 2013
    ..Kramer's proposal focuses on SS, a rare autoimmune disease that primarily affects the glands that produce tears and saliva...
  15. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2013
    ..Sporadic spontaneous reactivation of HSV-1 causes shedding of virus in tears leading to spread of virus to other individuals, and can also cause recurrent Herpes Stromal Keratitis (HSK), a ..
  16. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2013
    ..Collectively, these data lead us to hypothesize that: (i) anti-MBP IgA in tears of normal individuals provide the first line of defense by inhibiting the adhesion of parasites to host cells and ..
  17. Cartilage Degeneration and Repair By ADAMTSs and Hyaluronan Binding Proteins
    Anna H Plaas; Fiscal Year: 2013
    ..these are accompanied by progressive tissue changes which include cartilage erosion, synovial fibrosis, meniscal tears and bony remodeling...
  18. Patient Oriented Research and Mentoring Program in Orthopedics
    Elena Losina; Fiscal Year: 2013
    ..Study 2: To determine the diagnostic value of clinical history for the diagnosis of symptomatic meniscal tears in the presence of knee osteoarthritis (OA)...
  19. Rotator cuff repair using hyaluronan enriched fascia extracellular matrix
    KATHLEEN ANNE DERWIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rotator cuff tears affect 40% or more of those over age 60 and cost the US economy approximately $3 billion per year...
  20. IRIS: Incorporating Research Into Sight
    Catherine Anne McCarty; Fiscal Year: 2013
    ..to lOP lowering medications, AMD, response to AMD treatment, tear film insufficiency, response to artificial tears used to treat tear film insufficiency Aim lb...
  21. The Role of Periostin and Th2 Cytokines in Eosinophilic Esophagitis Fibrogenesis
    Edaire Cheng; Fiscal Year: 2013
    ..with tissue remodeling characterized by a unique pattern of subepithelial fibrosis leading to painful mucosal tears, odynophagia, dysphagia, and strictures...
  22. Noninvasive measurement of intervertebral disc mechanics with MR Elastography
    Alexander C Wright; Fiscal Year: 2012
    ..of the nucleus from a gelatinous material to a fibrous one, structural changes in the AF, followed by fissures and tears in the AF. Early diagnosis of disc degeneration is critical for the success of any biological treatment strategy...
  23. Rotator Cuff Degeneration and Repair
    Stavros Thomopoulos; Fiscal Year: 2013
    ..Degenerative changes can lead to massive, irreparable rotator cuff tears through attritional changes in the tendons and irreversible fatty degeneration of the rotator cuff muscles...
  24. PAR-1b in Integrin Localization and Laminin-111 Assembly in the Salivary Gland
    ELISE GERVAIS; Fiscal Year: 2013
    ..exocrine glands, including the salivary glands and the lacrimal glands, decreasing secretory products (saliva and tears) and causing significant decreases in the patient's quality of life...
  25. Cartilage, Bone and Marrow Interactions in Knee OA
    Ravinder Reddy Regatte; Fiscal Year: 2013
    ..by many risk factors such as joint malalignment, obesity, trauma, meniscal abnormalities or cruciate ligament tears, biochemical, biomechanical, genetic, and environmental...
  26. Dry-responsive corneal afferents, TRPM8, and regulation of tears
    Ian D Meng; Fiscal Year: 2013
    ..properties would be expected of neurons that participate in the regulation of basal tearing, as evaporation of tears from the corneal surface causes both cooling and increased osmolarity of the tear film...
  27. Determining the Genetic Basis of Rotator Cuff Disease
    Robert Z Tashjian; Fiscal Year: 2013
    ..The purpose of this study is to create a powerful resource of patients diagnosed with full- thickness rotator cuff tears with DNA samples and complete phenotype data and to perform a genome-wide association analysis of these patients ..
  28. 2010 Biology and Pathobiology of The Cornea
    Shukti Chakravarti; Fiscal Year: 2010
    ..These functional demands are met by the tears, appropriate tissue hydration, biomechanical strength, barrier properties, immune modulation and restricted ..
  29. Novel Biomaterials as Sealants for Applications in Annulus Fibrosus Repair
    Clare Canal Guterl; Fiscal Year: 2012
    ..needle injection of biologics or discography, discectomy procedures for herniations, or other small lesions and AF tears. These types of defects are linked with accelerated IVD degeneration...
  30. Expandable Shape-Memory Polymers for Suture Anchors
    Christopher M Yakacki; Fiscal Year: 2011
    ..In recent studies, over 54% of patients over the age of 60 with shoulder pain had evidence of rotator cuff tears. Patients with poor bone mass densities are highly at risk of device failure as bone density have been correlated ..
  31. The Pathophysiology of Rotator Cuff Tendon Injury and Healing in the Presence of
    Stephen John Thomas; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Rotator cuff tendon tears are a widespread orthopedic problem that often requires surgical repair to eliminate pain and restore function...
  32. Rotator Cuff Tears: Optimizing Diagnosis and Treatment Strategies
    Nitin B Jain; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rotator cuff tears are the most common cause of shoulder disability and pain accounting for 4.5 million physician visits and 75,000 surgeries annually...
  33. Nanofiber Scaffolds with Gradations in Mineral Content for Rotator Cuff Repair
    Younan Xia; Fiscal Year: 2013
    ..Our goal is to design, fabricate, and validate novel nanostructures for use in the surgical repair of rotator cuff tears to restore the torn tendon to its bony insertion...
  34. Poloxamer 188 mechanism of action in ischemic heart failure.
    Bruce E Markham; Fiscal Year: 2010
    ..The long-term goal of this project is to establish a role for membrane tears in the progression of heart failure and to demonstrate that P- 188 interacts with damaged membranes to prevent ..
  35. Modeling Novel Treatments for Dry Eye
    GORDON WILLIAM LAURIE; Fiscal Year: 2011
    ..Increased levels of proinflammatory cytokine TNFa in tears of dry eye patients is associated with damage to ocular surface epithelia...
  36. Anemia in the Elderly: Pathogenesis
    Jeffrey S Friedman; Fiscal Year: 2010
    ..damage to erythrocytes will be assessed by estimating GSSG/GSH, glutathione peroxidase, carbonyl proteins, TEARS;exposure of phosphatidylserine on erythrocyte membranes will be documented...
  37. The Physiological Basis of Rotator Cuff Muscle Rehabilitation
    SAMUEL RICHARD WARD; Fiscal Year: 2013
    ..Our central hypothesis is that rotator cuff tears induce a continuum of muscle atrophy and fibrosis, leading to a critical threshold, beyond which rehabilitation ..
  38. Structure Function Relationships at the Tendon to Bone Insertion Site
    Stavros Thomopoulos; Fiscal Year: 2010
    ..Clinical outcomes have frequently been disappointing (e.g., at the rotator cuff the recurrence of tears to repaired tendons has been reported to be as high as 94%3,7,8)...
  39. The Effect of Age on Functional ACL Healing
    Martha M Murray; Fiscal Year: 2013
    ..In this competitive renewal, we will determine if the impaired healing potential of adolescent ACL tears can be improved in vivo by using an enhanced repair strategy in which a scaffold stimulates increased cellular ..
  40. Tribosupplementation of Injured Joints
    Gregory D Jay; Fiscal Year: 2013
    ..In particular, patients with meniscal tears are at high risk for early PTOA...
  41. Enhanced tendon to bone healing
    Stavros Thomopoulos; Fiscal Year: 2010
    ..At the rotator cuff, where there are no repair techniques that are immune from recurrent tears, short to mid term failure rates have been reported to be as high as 94%...
  42. 3T Pelvic MRI Measures After Childbirth: Pre-Pregnancy and 6 Months Postpartum (R
    Holly E Richter; Fiscal Year: 2010
    ..FI and UI are more common in patients with internal anal sphincter defects and levator muscle tears, but it is unknown whether anatomical findings on postpartum pelvic imaging are directly attributable to birth ..
  43. Muscle function and compensation following rotator cuff tear in older adults
    MEGHAN ELISE VIDT; Fiscal Year: 2013
    ..To better understand the relationships between healthy aging, rotator cuff tears, and functional ability, it is necessary investigate compensation in ADLs and identify the strength and activation ..
  44. Non-invasive Morphologic and Biochemical Assessment of Tendon with Novel UTE-MRI
    Eric Y Chang; Fiscal Year: 2013
    ..tendon in asymptomatic volunteers as well as symptomatic patients with tendinosis (overuse), traumatic tendon tears, and psoriatic arthropathy...
  45. Hyaluronan Enriched Fascia ECM for Rotator Cuff Repair
    LIKANG CHIN; Fiscal Year: 2010
    ..For large, chronic tears, surgical intervention can improve clinical outcomes, but re-tear rates are reportedly as high as 94%...
  46. Stimulation of Tear Secretion by a Novel Glycoprotein
    John Sheppard; Fiscal Year: 2009
    ..A natural component of tears, lacritin not only stimulates the cornea/lacrimal gland axis to increase tear production, but also promotes the ..
  47. In vivo ACL Reconstruction Biomechanics
    Guoan Li; Fiscal Year: 2012
    ..patients will be divided into three groups, those with no meniscal injury, those with medial meniscal tears, and those with lateral meniscal tears...
  48. RESEARCH ON NORMAL AND ABNORMAL MECHANISMS OF VISION
    Larry A Palmer; Fiscal Year: 2013
    ..molecularbiology);retina (circuitry, computation, neurochemistry, developmental genetics);eye (cataract, myopia, tears);central pathways (physiology, computation);higher processes (psychophysics, cognitive neuroscience, computation);..
  49. Knee CAT Study - Validity of PROMIS Pain Interference and Physical Function CATs
    James J Irrgang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anterior cruciate ligament (ACL) injuries, meniscus tears and osteoarthritis (OA) are common conditions affecting the knee that lead to substantial pain and limitations in physical function...
  50. A novel therapeutic for the treatment of persistent corneal epithelial defects
    Bennie H Jeng; Fiscal Year: 2010
    ..In general, traditional therapy of PED consists of aggressive lubrication with preservative-free artificial tears and ointments, the use of bandage soft contact lenses, pressure patching, punctal plugging, and the surgical ..
  51. Trafficking of plgR in Lacrimal Gland
    Sarah F Hamm Alvarez; Fiscal Year: 2010
    ..The major source of tear proteins is the lacrimal gland acinar cell. The major antibody present in tears is dimeric IgA (dlgA), which associates with the polymeric immunoglobulin A receptor (plgR) at epithelial cell ..
  52. Biochemistry and Biophysics of the Preocular Tear Film
    Igor A Butovich; Fiscal Year: 2013
    ..The goal of the project is to investigate the biochemical changes in lipid composition of human aqueous tears and meibomian gland secretions and the corresponding biophysical changes in TF that occur in CPB in order to ..
  53. Interferometric Studies of the Fluid Dynamics of the Tear Film
    PETER E KING-SMITH; Fiscal Year: 2012
    ..Tear thinning could be caused either by evaporation or by divergent "tangential flow" of tears along the corneal surface...
  54. Patterning instructive biomolecular cues into collagen scaffolds for tendon inser
    Brendan A Harley; Fiscal Year: 2013
    ..Re-tears are frequent after clinical intervention because current surgical strategies forsake interface regeneration (..
  55. Injury from Sexual Assault: Addressing Health Disparity
    Marilyn S Sommers; Fiscal Year: 2010
    ..adjusting for biometrically-derived measures of skin color;and 3) if there is a constellation of injury types (Tears, Ecchymoses, Abrasions, Redness, Swelling, or TEARS) and severities within specific anatomical locations that best ..
  56. Optical Reflectometry for Tear Film Measurement
    Michael R Wang; Fiscal Year: 2010
    ..DES is a common multi-factorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with ..
  57. Molecular pathophysiology of massive rotator cuff tears
    Brian Feeley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rotator cuff tears (RCTs) are an extremely common cause of shoulder pain and disability. Up to 20% of patients greater than the age of 50 years of age have evidence of a rotator cuff tear...
  58. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010
    ..The absence of tears, in severe cases, can lead to abrasion of the corneal surface and blindness...
  59. Microtechnology-Enhanced Surgical Device For Pediatric Lens Capsulotomy And Treat
    Christopher Keller; Fiscal Year: 2011
    ..Capsule tears hinder lens removal and affect the mechanical stability and performance of artificial lens implants...
  60. A Biomechanical Study of Work-Related Shoulder Disorder
    ANDREW ROBERT KARDUNA; Fiscal Year: 2010
    ..support the concept that abnormal loading may lead to a progression from acute tendinitis to chronic rotator cuff tears, the results from this proposal will also serve as the basis for more effective treatment and prevention ..
  61. An injectable biocompatible hydrogel nucleus pulposus replacement
    Gavin Braithwaite; Fiscal Year: 2009
    ..gel at body temperature and environment within minutes;(iii) to be space-filling and resist extrusion from annular tears, (iv) to survive at least 1 million cycles of dynamic loading with a peak load of 3 kN;and (v) be revisable to ..
  62. Protection of the cornea from UVB radiation by elevated potassium in tears
    John L Ubels; Fiscal Year: 2013
    Project summary The tears, for the most part, have an electrolyte composition like other extracellular fluids...
  63. Biologic scaffold prostheses to enhance meniscus repair
    JOE WEINBERG; Fiscal Year: 2009
    ..work to United States public health and the VA patient care mission: Many veterans have meniscal injuries and tears. Meniscal injuries may be secondary to overt trauma, or in other cases, meniscal pathology may reflect alterations ..
  64. BONE MARROW TRANSPLANTATION FOR MUCOPOLYSACCHARIDOSIS
    Chester Whitley; Fiscal Year: 1993
    ..to study small increments of enzyme activity in nonhematologic tissues and fluids (eg, liver, cerebrospinal fluid, tears) after stem cell engraftment...
  65. LUNG CAPILLARY PERMEABILITY WITH HIGH VASCULAR PRESSURES
    Mary Townsley; Fiscal Year: 1991
    ..the gross anatomic sites of pressure-induced versus chemically-induced ling injury -are there gross leaks or tears in the alveolo-capillary barrier? Pulmonary microvascular permeability will be assessed by measuring the capillary ..
  66. Protection of Ocular Tissues During Inflammation
    MELVIN MEDOF; Fiscal Year: 2006
    ..In the previous grant cycle, we showed that functionally active soluble forms of the molecules are present in tears and aqueous humor, and obtained evidence that changes in the cell-associated regulators are clinically relevant in ..
  67. Behavioral Multimedia for ACL Reconstructive Surgery
    Britton Brewer; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Approximately 80,000 Americans sustain acute tears of the anterior cruciate ligament (ACL) of the knee each year, with associated healthcare costs estimated at roughly $1 billion dollars ..
  68. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2007
    ..These in vitro events will be connected to in vivo comparisons of mediators in tears (ILlb, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNFcq IFNy, histamine, soluble TNF receptor 1) and expression ..
  69. Enabling ACL Repair Using Proprietary Collagen Device
    Emma Wright; Fiscal Year: 2009
    ..composite has been developed and validated by the investigators in a canine model to heal partial ACL tears both biomechanically and histologically...
  70. Rotator cuff tendon to bone insertion site healing
    Louis J Soslowsky; Fiscal Year: 2010
    ..cuff tendons to heal back to bone following injury is limited, and failure of surgically repaired rotator cuff tears in humans has been reported in 20-70% of cases...
  71. HAPTOTACTIC REPAIR OF THE MENISCUS
    CAHIR MCDEVITT; Fiscal Year: 2002
    ..The data in the literature supporting a casual relationship between tears and meniscus and damage to the articular cartilage is persuasive...
  72. TEAR ABNORMALITIES IN NEUROLOGICAL DISEASES
    Patricia Coyle; Fiscal Year: 1990
    Two major objectives will e pursued: 1. a study on the composition of tears in a prototype neuroimmune disorder (multiple sclerosis [MS]) which may involve abnormalities in mucosal immunity; and 2...