Genomes and Genes
Summary: An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
Publications307 found, 100 shown here
- Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretionLiqing Yu
McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 99:16237-42. 2002Cholesterol and other sterols exit the body primarily by secretion into bile. In patients with sitosterolemia, mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 or ABCG8, lead to reduced secretion of sterols ..
- Real-time PCR-based analysis of the human bile microRNAome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancerKengo Shigehara
Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tokyo, Japan
PLoS ONE 6:e23584. 2011..The aim of this study was to confirm the existence of miRNAs in human bile and to assess their potential as clinical biomarkers for BTC...
- Bile acids as regulatory moleculesPhillip B Hylemon
Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0678, USA
J Lipid Res 50:1509-20. 2009In the past, bile acids were considered to be just detergent molecules derived from cholesterol in the liver...
- Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administrationA C Bulmer
Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Queensland, Australia
Br J Pharmacol 164:1857-70. 2011..Despite the therapeutic potential of bile pigments, little is known about their in vivo parenteral or enteral absorption after exogenous administration...
- Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levelsK F Kozarsky
Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia 19104, USA
Nature 387:414-7. 1997..mediate these effects by increasing hepatic HDL cholesterol uptake or by increasing cholesterol secretion into bile, or both...
- Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal diseaseRaffaella M Gadaleta
Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
Biochim Biophys Acta 1801:683-92. 2010The nuclear receptor Farnesoid X Receptor (FXR) critically regulates nascent bile formation and bile acid enterohepatic circulation...
- Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasisTim O Lankisch
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
Hepatology 53:875-84. 2011..We hypothesize that bile proteomic analysis distinguishes CC from nonmalignant lesions...
- Bile leakage after hepatic resectionY Yamashita
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Ann Surg 233:45-50. 2001To identify the perioperative risk factors for postoperative bile leakage after hepatic resection, to evaluate the intraoperative bile leakage test as a preventive measure, and to propose a treatment strategy for postoperative bile ..
- Bear bile: dilemma of traditional medicinal use and animal protectionYibin Feng
School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, PR China
J Ethnobiol Ethnomed 5:2. 2009Bear bile has been used in Traditional Chinese Medicine (TCM) for thousands of years...
- Biofilm formation and interaction with the surfaces of gallstones by Salmonella sppA M Prouty
Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Infect Immun 70:2640-9. 2002..form biofilms on the surfaces of gallstones, where the bacteria are protected from high concentrations of bile and antibiotics...
- Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseasesMichael Trauner
Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
Wien Med Wochenschr 158:542-8. 2008Alterations in bile secretion at the hepatocellular and cholangiocellular levels may cause cholestasis. Formation of 'toxic bile' may be the consequence of abnormal bile composition and can result in hepatocellular and/or bile duct injury...
- Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bileA M Prouty
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC 7758, San Antonio, TX 78229 3900, USA
FEMS Immunol Med Microbiol 41:177-85. 2004DNA microarrays and two-dimensional (2-D) gel electrophoresis were utilized to analyze the global effect of bile on transcription and protein synthesis in Salmonella enterica serovar Typhimurium...
- Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitisJ G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
Gastroenterology 114:755-63. 1998..Because several Helicobacter sp. colonize the livers of animals and induce hepatitis, the aim of this study was to determine whether Helicobacter infection was associated with cholecystitis in humans...
- Efficacy and safety of fully covered self-expandable metallic stents in biliary complications after liver transplantation: a preliminary studyMario Traina
Mediterranean Institute for Transplantation and Advanced Specialized Therapies University of Pittsburgh Medical Center, Palermo, Italy
Liver Transpl 15:1493-8. 2009..A cost analysis should be performed in order to evaluate whether to treat transplanted patients suffering from biliary complications with covered self-expandable metallic stent placement as first-line therapy...
- Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouseDavid Q H Wang
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Physiol Gastrointest Liver Physiol 285:G494-502. 2003We explored the influence of the hydrophilic-hydrophobic balance of a series of natural bile acids on cholesterol absorption in the mouse. Male C57L/J mice were fed standard chow or chow supplemented with 0...
- Proteomic analysis of human bile from malignant biliary stenosis induced by pancreatic cancerAnnarita Farina
Biomedical Proteomics Research Group, Department of Bioinformatics and Structural Biology, Faculty of Medicine, Geneva University, Geneva CH 1211, Switzerland
J Proteome Res 8:159-69. 2009Stenosis of the common bile duct may be either due to benign (chronic pancreatitis) or malignant (cholangiocarcinoma, pancreatic adenocarcinoma) conditions...
- Rapid determination of reduced and oxidized glutathione levels using a new thiol-masking reagent and the enzymatic recycling method: application to the rat liver and bile samplesImam H Shaik
School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
Anal Bioanal Chem 385:105-13. 2006..plate assay for quantitation of reduced (GSH) and oxidized (GSSG) glutathione in the rat liver tissue and bile is described...
- Chemotactic response of Helicobacter pylori to human plasma and bileMulugeta L Worku
Department of Medical Microbiology, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1NY, UK
J Med Microbiol 53:807-11. 2004..the role of chemotaxis in Helicobacter pylori colonization, the in vitro bacterium response to human plasma and bile (secretions containing chemoeffector compounds that are present in the gastric mucus layer) was examined...
- Adaptation and preadaptation of Salmonella enterica to BileSara B Hernández
Departamento de Genetica, Universidad de Sevilla, Sevilla, Spain
PLoS Genet 8:e1002459. 2012b>Bile possesses antibacterial activity because bile salts disrupt membranes, denature proteins, and damage DNA. This study describes mechanisms employed by the bacterium Salmonella enterica to survive bile...
- A proteomic analysis of human bileTroels Zakarias Kristiansen
McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
Mol Cell Proteomics 3:715-28. 2004We have carried out a comprehensive characterization of human bile to define the bile proteome...
- Genetic characterization of the bile salt response in Lactobacillus plantarum and analysis of responsive promoters in vitro and in situ in the gastrointestinal tractPeter A Bron
Wageningen Centre for Food Sciences, NIZO Food Research, P O Box 20, 6710 BA Ede, The Netherlands
J Bacteriol 186:7829-35. 2004In this paper we describe the growth, morphological, and genetic responses of Lactobacillus plantarum WCFS1 to bile. Growth experiments revealed that a stepwise increase in the porcine bile concentration led to a gradual decrease in the ..
- Intraoperative indocyanine green fluorescent imaging for prevention of bile leakage after hepatic resectionMasaki Kaibori
Department of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka 573 1191, Japan
Surgery 150:91-8. 2011b>Bile leakage is a common complication of hepatectomy, and is associated with an increase in sepsis and liver failure. There are no standard preventive methods against bile leakage after hepatic surgery...
- Bile leak test by indocyanine green fluorescence images after hepatectomyTakanori Sakaguchi
Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
Am J Surg 200:e19-23. 2010b>Bile leak remains a serious complication after hepatectomy. The conventional leak test by intrabiliary injection of normal saline solution is not sensitive...
- Impact of endoscopic intervention in 100 patients with suspected postcholecystectomy bile leakArthur John Kaffes
Gastrointest Endosc 61:269-75. 2005b>Bile leak is a recognized complication of cholecystectomy. Endoscopic intervention is widely accepted as a treatment for this complication, but the optimal form is not well defined.
- Large-scale identification of human biliary proteins from a cholesterol stone patient using a proteomic approachHu Zhou
Research Centre for Proteome Analysis, Key Lab of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Rapid Commun Mass Spectrom 19:3569-78. 2005Gallbladder bile, one of the most important body fluids, is composed of water, inorganic ions, conjugated bile salts, phospholipids, cholesterol, bilirubin, mucin and proteins...
- A step further in the analysis of human bile proteomeAnnarita Farina
Biomedical Proteomics Research Group, Department of Bioinformatics and Structural Biology, Geneva University, Geneva CH 1211, Switzerland
J Proteome Res 10:2047-63. 2011b>Bile was shown to collect proteins known as potential cancer biomarkers...
- Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulationTakahiro Tsuboyama
Department of Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Radiology 255:824-33. 2010..To investigate the mechanism of enhancement of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) images and to characterize HCC thus enhanced...
- Identification of a bile-induced exopolysaccharide required for Salmonella biofilm formation on gallstone surfacesRobert W Crawford
Center for Microbial Interface Biology and Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
Infect Immun 76:5341-9. 2008..suggesting that this bacterium utilizes novel mechanisms to mediate enhanced colonization and persistence in a bile-rich environment...
- Repair of DNA damage induced by bile salts in Salmonella entericaAna I Prieto
Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, Seville 41080, Spain
Genetics 174:575-84. 2006..or sodium glycochenodeoxycholate induces the SOS response, indicating that the DNA-damaging activity of bile resides in bile salts...
- DNA micro-array-based identification of bile-responsive genes in Lactobacillus plantarumP A Bron
Wageningen Centre for Food Sciences, Wageningen, The Netherlands
J Appl Microbiol 100:728-38. 2006The purpose of this study was to determine the global transcriptional response in a food-associated lactic acid bacterium during bile stress.
- Biliary lipids, water and cholesterol gallstonesKarel J van Erpecum
Department of Gastroenterology, University Hospital Utrecht, Utrecht, The Netherlands
Biol Cell 97:815-22. 2005Cholesterol supersaturation, hydrophobic bile salts, pronucleating proteins and impaired gall-bladder motility may contribute to gallstone pathogenesis...
- ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretionMichael A Cater
Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Australia
Gastroenterology 130:493-506. 2006The Wilson protein (ATP7B) regulates levels of systemic copper by excreting excess copper into bile. It is not clear whether ATP7B translocates excess intrahepatic copper directly across the canalicular membrane or sequesters this copper ..
- Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapyKenneth D R Setchell
Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Gastroenterology 124:217-32. 2003Inborn errors of bile acid metabolism may present as neonatal cholestasis and fat-soluble vitamin malabsorption or as late onset chronic liver disease...
- Vibrio cholerae OmpU and OmpT porins are differentially affected by bileJamie A Wibbenmeyer
Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
Infect Immun 70:121-6. 2002..It was recently shown that bile stimulates the ToxR-mediated transcription of ompU and that ompU-expressing strains are more resistant to bile and ..
- Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transportersK E Berge
Department of Molecular Genetics and McDermott Center for Human Growth and Development and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
Science 290:1771-5. 2000..These data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis...
- Bile-based detection of extrahepatic cholangiocarcinoma with quantitative DNA methylation markers and its high sensitivitySo Hyun Shin
Laboratory of Epigenetics, Cancer Research Institute, Seoul, South Korea
J Mol Diagn 14:256-63. 2012Extrahepatic cholangiocarcinoma (EHC) is usually difficult to diagnose by bile cytology because of cellular disintegration. However, DNA samples from bile fluid can provide sufficient materials to screen for the presence of EHC...
- Review article: the role of bile and pepsin in the pathophysiology and treatment of gastro-oesophageal reflux diseaseJ Tack
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Aliment Pharmacol Ther 24:10-6. 2006..Animal studies suggest that synergism between acid and pepsin and conjugated bile acids have the greatest damaging potential for oesophageal mucosa, although unconjugated bile acids may be caustic ..
- Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19C Gälman
Department of Endocrinology, Metabolism and Diabetes, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
J Intern Med 270:580-8. 2011b>Bile acid (BA) synthesis is essential in cholesterol and lipid homoeostasis.
- Shotgun proteomics of human bile in hilar cholangiocarcinomaShahid G Farid
Department of Hepatopancreaticobiliary Surgery, St James s University Hospital, Leeds, UK
Proteomics 11:2134-8. 2011..to find biomarkers for hepatobiliary diseases including cholangiocarcinoma (CCA) has led to an interest in using bile as a proximal fluid in biomarker discovery experiments, although there are inherent challenges both in its ..
- A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterolEric L Klett
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
BMC Med 2:5. 2004..No phenotypic difference has yet been described in humans with complete defects in either ABCG5 or ABCG8. These proteins, based upon the defects in humans, are responsible for regulating dietary sterol entry and biliary sterol secretion...
- Critical role of multidrug efflux pump CmeABC in bile resistance and in vivo colonization of Campylobacter jejuniJun Lin
Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio 44691, USA
Infect Immun 71:4250-9. 2003..In this study, we examined the role of CmeABC in bile resistance and its contribution to the adaptation of Campylobacter jejuni in the intestinal tract of the chicken, a ..
- Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1Torsten Plosch
Center for Liver, Digestive, and Metabolic Diseases, Groningen University Institute for Drug Exploration, Department of Pediatrics, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Biol Chem 277:33870-7. 2002..Thus, activation of LXR in mice leads to enhanced hepatobiliary cholesterol secretion and fecal neutral sterol loss independent of (ABCA1-mediated) elevation of HDL and the presence of ABCA1 in liver and intestine...
- Risk factors and management of postoperative bile leakage after hepatectomy without bilioenteric anastomosisHiromichi Ishii
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan ishii0512h yahoo co jp
Dig Surg 28:198-204. 2011b>Bile leakage frequently causes major complications after hepatic resection...
- The role of cilia in the regulation of bile flowNicholas F Larusso
Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minn, USA
Dig Dis 29:6-12. 2011Cholangiocytes, the epithelial cells lining intrahepatic bile ducts, are ciliated cells...
- The White test: a new dye test for intraoperative detection of bile leakage during major liver resectionSilvio Nadalin
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
Arch Surg 143:402-4; discussion 404. 2008To describe a new intraoperative bile leakage test in patients undergoing a major liver resection aimed to combine the advantages of each of the other standard bile leakage tests (accurate visualization of leaks, reproducibility, and ease ..
- Bile tolerant Lactobacillus reuteri isolated from pig feces inhibits enteric bacterial pathogens and porcine rotavirusByeong Joo Seo
Department of Applied Microbiology and Biotechnology, Yeungnam University, Kyongsan, Kyeongbuk, South Korea
Vet Res Commun 34:323-33. 2010..This strain was resistant to pH 2.0, 5% porcine bile and exhibited antimicrobial activity against all the thirteen enteric bacterial pathogens tested...
- Helicobacter pylori protein response to human bile stressChunhong Shao
Department of Microbiology, School of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong 250012, PR China
J Med Microbiol 57:151-8. 2008The ability of Helicobacter pylori to tolerate bile is likely to be important for its colonization and survival in the gastrointestinal tract of humans...
- Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cellsE Jaensson-Gyllenbäck
Department of Experimental Medical Sciences, Immunology Section, Lund University, Lund, Sweden
Mucosal Immunol 4:438-47. 2011..We found that bile contained high levels of retinol, induced RA receptor-dependent retinol-metabolizing activity in bone marrow-..
- Diagnosis and management of bile leaks after blunt liver injuryWendy L Wahl
Trauma Burn Center, University of Michigan Health System, Ann Arbor 48109 0033, USA
Surgery 138:742-7; discussion 747-8. 2005..Furthermore, bile leaks are emerging as frequent complications of NOM...
- Bile leakage and liver resection: Where is the risk?Lorenzo Capussotti
Unit of Surgical Oncology, Institute for Cancer Research and Treatment, Candiolo, Italy
Arch Surg 141:690-4; discussion 695. 2006The knowledge of risk factors for bile leakage after liver resection could reduce its incidence.
- Transformation of benign Barrett's epithelium by repeated acid and bile exposure over 65 weeks: a novel in vitro modelKiron M Das
Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Int J Cancer 128:274-82. 2011..The aim of the study is to determine if repeated exposure to acid and bile confers a tumorigenic phenotype in a telomerase (hTERT)-immortalized benign Barrett's cell line (BAR-T)...
- Cholestasis and cholestatic syndromesGideon M Hirschfield
Liver Centre, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, Canada
Curr Opin Gastroenterol 25:175-9. 2009..Cholestatic liver injury is encountered across a wide variety of clinical scenarios ranging from toxin-induced, genetic, to autoimmune in nature. This review summarizes recent findings from what is a burgeoning clinical field...
- Proteomic analysis of human bile and potential applications for cancer diagnosisAnnarita Farina
Biomedical Proteomics Research Group, Department of Bioinformatics and Structural Biology, Faculty of Medicine, Geneva University, Switzerland
Expert Rev Proteomics 6:285-301. 2009b>Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum...
- Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic ratsVicente Lorenzo-Zúñiga
Departments of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Hepatology 37:551-7. 2003Experiments were performed to test whether conjugated bile acid administration would decrease bacterial overgrowth, bacterial translocation, and endotoxemia in ascitic cirrhotic rats...
- Role of bile in pathogenesis of indomethacin-induced enteropathyMolly Jacob
Department of Biochemistry, Christian Medical College, Vellore 632002, India
Arch Toxicol 81:291-8. 2007..These effects lead to increased intestinal permeability and inflammation. Luminal bile acids play a controversial role in the damage produced by these drugs...
- Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptorTorsten Plosch
Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
Gastroenterology 126:290-300. 2004..It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux from enterocytes into the intestinal lumen.
- Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio choleraeArpita Chatterjee
Biophysics Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Calcutta 700 032, India
Infect Immun 75:1946-53. 2007b>Bile induces pleiotropic responses that affect production of virulence factors, motility, and other phenotypes in the enteric pathogen Vibrio cholerae...
- Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyriaL Meerman
Center for Liver, Digestive, and Metabolic Diseases, Groningen Institute for Drug Studies, Groningen, The Netherlands
Gastroenterology 117:696-705. 1999..METHODS: Liver histology, indicators of lipid peroxidation, plasma parameters of liver function, and bile composition were studied in mice homozygous (fch/fch) for a point mutation in the ferrochelatase gene and in ..
- Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangiolesPeter Fickert
Department of Medicine, Karl Franzens University, Graz, Austria
Gastroenterology 123:1238-51. 2002The effects of ursodeoxycholic acid (UDCA) in biliary obstruction are unclear. We aimed to determine the effects of UDCA in bile duct-ligated and in Mdr2 knockout (Mdr2(-/-)) mice with biliary strictures.
- Biliary secretion and excretion in health and disease: current conceptsAlan F Hofmann
Division of Gastroenterology Department of Medicine University of California, San Diego California 92093 0813, USA
Ann Hepatol 6:15-27. 2007..biology have enabled cloning of the transporters involved in biliary secretion and the enterohepatic circulation of bile acids. This, in turn has permitted elucidation of their function as well as their regulation by nuclear receptors...
- Physiology of bile secretionAlejandro Esteller
Department of Physiology and Pharmacology, University of Salamanca, Campus Miguel de Unamuno, Salamanca 37007, Spain
World J Gastroenterol 14:5641-9. 2008The formation of bile depends on the structural and functional integrity of the bile-secretory apparatus and its impairment, in different situations, results in the syndrome of cholestasis...
- Salmonella enterica serovar typhimurium resistance to bile: identification and characterization of the tolQRA clusterAngela M Prouty
Department of Microbiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Bacteriol 184:1270-6. 2002Salmonella enterica serovar Typhimurium is resistant to the action of bile salts, and resistance to bile is enhanced in strains in which the PhoP-PhoQ (PhoPQ) two-component regulatory system has been activated...
- Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in miceHarmen Wiersma
Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
J Lipid Res 50:1571-80. 2009High density lipoprotein cholesterol is thought to represent a preferred source of sterols secreted into bile following hepatic uptake by scavenger receptor class B type I (SR-BI)...
- Detection of hepatitis E virus in liver, mesenteric lymph node, serum, bile and faeces of naturally infected pigs affected by different pathological conditionsNilsa de Deus
Centre de Recerca en Sanitat Animal CReSA, Campus de la UAB Edifici CReSA, 08193 Bellaterra Barcelona, Spain
Vet Microbiol 119:105-14. 2007..Serum, bile, liver, lymph nodes and faeces of 69 animals from 1 week to 4 months of age with different pathological conditions ..
- Comparative proteomics of excretory-secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex hostRussell M Morphew
Institute of Biological Sciences, University of Wales, Aberystwyth, Wales SY23 3DA, United Kingdom
Mol Cell Proteomics 6:963-72. 2007..hepatica in vivo, within ovine host bile, with classical ex host in vitro ES methods. Only cathepsin L proteases from F...
- Role of the gastric refluxate in gastroesophageal reflux disease: acid, weak acid and bileJoel E Richter
Department of Medicine and Section of Gastroenterology and Hepatology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Am J Med Sci 338:89-95. 2009The role of acid, weak/nonacid, and bile in the genesis of esophageal mucosal damage and reflux symptoms is complex...
- Incidence and management of bile leakage after hepatic resection for malignant hepatic tumorsShogo Tanaka
Department of Gastroenterological and Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan
J Am Coll Surg 195:484-9. 2002b>Bile leakage is one of the frequent and disturbing complications of hepatic resection.
- Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in miceAstrid Kosters
Department of Experimental Hepatology, AMC Liver Center, Academic Medical Center, Meibergdreef 69 71, Amsterdam 1105 BK, The Netherlands
J Hepatol 38:710-6. 2003..The aim of our study was to correlate the expression levels of Abcg5 and Abcg8 to biliary cholesterol secretion in various (genetically-modified) mouse models...
- Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport functionM Pizarro
Departmento de Gastroenterologia, Pontificia Universidad Catolica de Chile, Santiago 833 0024, Chile
Gut 53:1837-43. 2004Obese Zucker rats (ZR) have been used as an experimental model for non-alcoholic fatty liver disease and are particularly susceptible to various types of liver injury. Bile secretory function has not been assessed in ZR.
- Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MSLei Chwen Lin
Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
J Pharm Biomed Anal 48:909-17. 2008..was developed to determine gastrodin and its metabolite p-hydroxybenzyl alcohol (HBA) in rat blood, brain and bile collected using microdialysis technique. The analytes were separated using a reversed phase column (4...
- Separation and quantitation of bile acids using an isocratic solvent system for high performance liquid chromatography coupled to an evaporative light scattering detectorE C Torchia
Department of Biochemistry and Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
Anal Biochem 298:293-8. 2001We developed a quantitative method for the analysis of bile acids using a high performance liquid chromatograph coupled to an evaporative light scattering detector...
- Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker ratAndreas Geier
Department of Gastroenterology, Aachen University RWTH, Aachen, Germany
J Hepatol 43:1021-30. 2005..Alterations in hepatobiliary transporters may render fatty livers more vulnerable against various toxic insults...
- Endoscopic therapy for bile leak based on a new classification: results in 207 patientsGurpal S Sandha
St Michael s Hospital, University of Toronto, Canada
Gastrointest Endosc 60:567-74. 2004b>Bile leak is among the most common complications of cholecystectomy. Endoscopic therapy is empiric; a systematic approach to management of bile leak has not been established.
- Cholic acid, a bile acid elicitor of hypersensitive cell death, pathogenesis-related protein synthesis, and phytoalexin accumulation in riceJinichiro Koga
Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, Sakado, Saitama 350 0289, Japan
Plant Physiol 140:1475-83. 2006..defense responses was isolated from human feces, and its structure was identified as cholic acid (CA), a primary bile acid in animals...
- ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bileSilvia Langheim
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Lipid Res 46:1732-8. 2005The major pathway for the removal of cholesterol from the body is via secretion into the bile. Three members of the ATP binding cassette (ABC) family, ABCG5 (G5), ABCG8 (G8), and ABCB4 (MDR2), are required for the efficient biliary export ..
- Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tractDebbie Watson
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
BMC Microbiol 8:176. 2008..Herein we outline a patho-biotechnology strategy to improve gastric delivery and host adaptation of a probiotic strain Bifidobacterium breve UCC2003 and the generally regarded as safe (GRAS) organism Lactococcus lactis NZ9000...
- NPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasisAndres Klein
Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile
Hepatology 43:126-33. 2006..plays a critical role in the metabolism of lipoprotein cholesterol and in controlling its elimination through the bile. Niemann-Pick type C 2 (NPC2), a cholesterol-binding protein, is key for normal intracellular trafficking of ..
- Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretionTsunehiro Shintani
Department of Biochemistry and Integrative Medical Biology, Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
Hepatology 49:141-50. 2009..In the mouse model of estradiol-induced cholestasis, CO overproduction by inducing HO-1 significantly improved the bile output through stimulating HCO(3) (-) excretion; such a choleretic response did not occur in the knockout mice.
- Bile acids: chemistry, physiology, and pathophysiologyMaria J Monte
Laboratory of Experimental Hepatology and Drug Targeting, CIBERehd, University of Salamanca, Salamanca 37007, Spain
World J Gastroenterol 15:804-16. 2009The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physical-chemical and biological characteristics...
- Quantitative analysis of bile acids in human plasma by liquid chromatography-electrospray tandem mass spectrometry: a simple and rapid one-step methodDebora Tagliacozzi
Laboratorio di Biochimica Clinica, Ospedale Pediatrico del Bambino Gesu IRCCS, Rome, Italy
Clin Chem Lab Med 41:1633-41. 2003b>Bile acids play a pivotal role in the metabolism of cholesterol and lipids. Their blood concentrations are important prognostic and diagnostic indicators of hepatobiliary and intestinal dysfunction...
- Transport systems in cholangiocytes: their role in bile formation and cholestasisM Strazzabosco
Instituto di Medicina Interna, Azienda Ospedaliera di Padova, Universita di Padova, Padua, Italy
Yale J Biol Med 70:427-34. 1997Formation of bile requires the coordinated function of two epithelial cell types: hepatocytes, that are responsible for secretion of the major osmolytes and biliary constituents and cholangiocytes that regulate the fluidity and alkalinity ..
- A bile based study of Clonorchis sinensis infections in patients with biliary tract diseases in Ulsan, KoreaKwang Ro Joo
Department of Internal Medicine, Kyung Hee University Hospital, 1 Hoigi dong, Dongdaemoon gu, Seoul 130 702, Korea
Yonsei Med J 46:794-8. 2005..We evaluated the infection states of CS in patients with biliary tract diseases using a bile sample...
- Identification of a novel type of CA19-9 carrier in human bile and sera of cancer patients: an implication of the involvement in nonsecretory exocytosisNaofumi Uozumi
Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, 1 7 Yamada oka, Suita 565 0871, Japan
J Proteome Res 9:6345-53. 2010..Here we report the identification and characterization of a novel type of CA19-9 carrier, BGM (bile globular membrane), which is thought to exist in normal bile and to be secreted into sera of patients with ..
- Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null miceIván L Csanaky
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
Hepatology 53:272-81. 2011..However, the role of the Oatp1b family in the hepatic uptake of bile acids (BAs) into the liver is unknown...
- Prevention of pancreaticojejunal anastomotic leakage after pancreaticoduodenectomy with separate internal drainage of bile and pancreatic fluidXian Wei Dai
Department of General Surgery, Second Clinical College, China Medical University, Shenyang 110004, China
Hepatobiliary Pancreat Dis Int 2:131-4. 2003..To introduce a new reconstructional procedure to decrease the complications after pancreaticoduodenectomy...
- Characterization and quantification of rat bile phosphatidylcholine by electrospray-tandem mass spectrometryW D Lehmann
Central Spectroscopy, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
Anal Biochem 246:102-10. 1997Rat bile phosphatidylcholine was structurally characterized and quantified by electrospray mass spectrometry using a triple quadrupole instrument...
- Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient miceLudwig Amigo
Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile
Hepatology 38:726-34. 2003..This work characterizes plasma lipoprotein cholesterol, hepatic cholesterol content, bile acid metabolism, biliary cholesterol secretion, and gallstone formation in HL-deficient mice and C57BL/6 controls ..
- Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acidLee R Hagey
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
Zoolog Sci 27:565-73. 2010The biliary bile salts of the medaka, the Japanese rice fish (Oryzias latipes) were isolated and identified. Only bile acids were present, and all were N-acylamidated with taurine...
- Role of transporter proteins in bile tolerance of Lactobacillus acidophilusErika A Pfeiler
Genomic Sciences Graduate Program, Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA
Appl Environ Microbiol 75:6013-6. 2009..mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile. These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential ..
- Lipopolysaccharides and beta-glucuronidase activity in choledochal bile in relation to choledocholithiasisT Osnes
Section of Gastroenterology, Ulleval Hospital, Oslo, Norway
Digestion 58:437-43. 1997..Common duct bile obtained at endoscopic retrograde cholangiography in 86 patients was assayed for LPS by a limulus amebocyte lysate ..
- Determination and pharmacokinetic analysis of salvianolic acid B in rat blood and bile by microdialysis and liquid chromatographyYen Fei Chen
Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
J Chromatogr A 1088:140-5. 2005..chromatography has been developed for continuous monitoring of protein-unbound salvianolic acid B in rat blood and bile. Microdialysis probes were inserted into the jugular vein/right atrium and bile duct of Sprague-Dawley rats, and a ..
- [Effects of ursolic acid on liver-protection and bile secretion]Xiaojuan Xiong
Yichun College, Yichun, Jiangxi 336000
Zhong Yao Cai 26:578-81. 2003To study the liver-protection and promoting bile secretion of ursolic acid.
- Presence of hepcidin-25 in biological fluids: bile, ascitic and pleural fluidsJayantha Arnold
Department of Gastroenterology, Ealing Hospital NHS Trust, Uxbridge Road, London UB1 3HW, United Kingdom
World J Gastroenterol 16:2129-33. 2010To examine body fluids such as ascitic fluid (AF), saliva, bile and pleural effusions for the presence of hepcidin using a novel radioimmunoassay (RIA).
- Origin of oxysterols in hepatic bile of patients with biliary infectionTadashi Yoshida
Division of Gastroenterology, Tsukuba Memorial Hospital and Institute of Clinical Medicine, University of Tsukuba, Japan
Am J Gastroenterol 98:2275-80. 2003..Although bile contains high concentrations of cholesterol, oxysterol concentrations in bile and the effect of infection on ..
- The application of HPLC-F and GC-MS to the analysis of selected hydroxy polycyclic hydrocarbons in two certified fish bile reference materialsGrete Jonsson
RF Akvamiljø, Mekjarvik 12, N 4070 Randaberg, Norway
J Environ Monit 5:513-20. 2003..1-hydroxy-pyrene (1-OH-PYR) and 3-hydroxy-benzo[a]pyrene (3-OH-BaP) have been analysed in two certified fish bile reference materials (CRMs) for exposure monitoring of PAHs in the aquatic environment...
- Bile-inducible efflux transporter from Bifidobacterium longum NCC2705, conferring bile resistanceMiguel Gueimonde
Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias IPLA, Consejo Superior de Investigaciones Cientificas CSIC, Villaviciosa, Asturias, Spain
Appl Environ Microbiol 75:3153-60. 2009..In order to exert their health benefits, these bacteria must overcome biological barriers, including bile salts, to colonize and survive in specific parts of the intestinal tract...
- From blood to bile: recent advances in hepatobiliary transportMarco Arrese
Departament of Gastroenterology, Catholic University of Chile School of Medicine, Santiago, Chile
Ann Hepatol 1:64-71. 2002Transport of endogenous and exogenous substances from blood to bile is an essential function of the liver...
- Identification of oxysterols in human bile and pigment gallstonesW G Haigh
Department of Medicine, VA Medical Center, Seattle, Washington 98195, USA
Gastroenterology 121:118-23. 2001..However, the presence of oxysterols in bile or gallstones has never been reported. METHODS: Fresh human bile and gallstones were collected...
- [Effect of hypolipidemic treatment on the composition of bile and the risk or cholesterol gallstone disease]A Zak
IV interni klinika 1 LF UK a VFN, Praha
Cas Lek Cesk 146:24-34. 2007..The degree of cholesterol saturation in gallbladder bile is the most important predictor of cholesterol crystal formation...
- Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in ratsGianfranco Alpini
Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center College of Medicine, and Central Texas Veterans Health Care System, Temple, Texas, USA
Gastroenterology 123:1226-37. 2002We tested the hypothesis that during bile duct obstruction, increased biliary bile acids trigger cholangiocyte proliferation and secretion by a phosphatidylinositol 3-kinase (PI3-K)-dependent pathway.
- Role of duodenal bile crystal analysis in idiopathic pancreatitisS K Sahoo
Department of General Surgery, S.C.B. Medical College and Hospital, Cuttack 753007, Orissa, India
Trop Gastroenterol 22:205-6. 2001BACKGROUND/AIM: The aim of this study was to find out the incidence and clinical use of duodenal bile crystal analysis in patients presenting with idiopathic pancreatitis...
- Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: PreclinicYasmin Wadia; Fiscal Year: 2013..technology to join and seal tissues for controlling the leakage of blood, gastrointestinal fluids, urine, bile, lymph, and cerebrospinal fluid...
- Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic DiseasStephen C Strom; Fiscal Year: 2010..of exogenous compounds such as drugs or toxins as well as endogenous compounds like hormones, bilirubin and bile acids and cholesterol. Liver-based metabolic disease can result from mutations in genes in these critical pathways...
- Hepatic Steatosis Modulation by Apo B Gene TranscriptionJANET DEHOFF SPARKS; Fiscal Year: 2010..In vivo VLDL production, hepatic lipid content, lipogenesis, bile acid synthesis, and -oxidation will be measured in rodents fed betaine...
- Fatty acid related regulation of enteric infectious diseaseFREDRICK JON KULL; Fiscal Year: 2012..of which there are numerous members throughout the bacterial world, is inhibited by fatty acids present in bile. In the structure of ToxT, a palmitoleic acid bridges the regulatory and DNA binding domains of the transcription ..
- Regulation of Bile Acid Synthesis by Nuclear ReceptorsJohn Y L Chiang; Fiscal Year: 2013..Recent studies have shown that bile acids not only are physiological detergents that facilitate absorption, transport, distribution and disposal of ..
- Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid MetabolismHUIPING ROSE ZHOU; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bile acids are crucial for lipid homeostasis in the liver. During the last decade, researchers have discovered that bile acids not only act as detergents, but also as important signaling molecules...
- Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondriaPETER J contact HAVEL; Fiscal Year: 2010..and signaling of GI hormones (GLP-1, PYY, and ghrelin), and the adipocyte hormone, adiponectin and by altering bile acid metabolism and intestinal microflora...
- Microsomal Cytochromes P450 and their Interactions with their Redox PartnersLucy A Waskell; Fiscal Year: 2013..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
- Histamine modulation of biliary proliferation and damageHeather L Francis; Fiscal Year: 2013..Cholangiocytes are epithelial cells lining the bile ducts and are responsible for the modification and release of bile into the duodenum...
- Role of Platelet derived growth factor receptor-a in Liver Patho-biologySATDARSHAN SINGH MONGA; Fiscal Year: 2013..Lastly, PDGFR[unreadable] upregulation was observed in hepatocytes during hepatic fibrosis in patients, and after bile duct ligation (BDL) in mice...
- MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALINGMoosa Mohammadi; Fiscal Year: 2013..acts in an endocrine fashion to regulate major metabolic processes including glucose, lipid, cholesterol, and bile acid metabolism, and phosphate/vitamin D homeostasis...
- Lipid Transport, Bile Acid Synthesis, and Cholesterol HomeostasisWilliam M Pandak; Fiscal Year: 2013..nuclear receptors that control the expression of genes involved in the regulation of cholesterol, fatty acid, and bile acid homeostasis;and, subsequently determining how expression of the encoded pathways correlates with respective ..
- ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSISJohn R Grider; Fiscal Year: 2013..Release of BDNF will be determined in response to physiological stimuli (mucosal stroking, free fatty acids, and bile salts), to neurotransmitters (CGRP and SP), and to paracrine agents (5-HT and endocannabinoids) known to mediate or ..
- Liver disease in CF: CFTR controls innate immunity in biliary epitheliumMario Strazzabosco; Fiscal Year: 2013..In Cftr-KO mice, bile flow and biliary secretion are reduced;however the spontaneous development of CFLD is extremely rare, suggesting ..
- NPC1L1 and Metabolic DiseasesLiqing Yu; Fiscal Year: 2013..To probe the molecular link between NPC1L1 deficiency and D2 activation, we will examine if bile acid metabolism differs between WT and L1KO mice on HFD because we found that many bile acid sensitive genes were ..
- Dietary Cholesterol and Defects in Cholesterol SynthesisROBERT DAVID STEINER; Fiscal Year: 2013..We further hypothesize that statins, bile acids, antioxidants and molecular chaperones selectively restore SLOS cell metabolism and function...
- Excessive Copper Levels Disrupt Hepatic Nuclear Receptor FunctionClavia Ruth Wooton-Kee; Fiscal Year: 2011..LEC) rat and Atp7b-/- mouse) have decreased expression of genes involved in several metabolic pathways, including bile acid synthesis (cholesterol 71-hydroxylase (Cyp7a1)), cholesterol synthesis (3-hydroxy-3-methyl-glutaryl-CoA ..
- Diet and Gastrointestinal Cancer Risk in African Americans and Rural AfricansSTEPHEN JD O'KEEFE; Fiscal Year: 2012..Our studies have also showed higher populations of secondary bile salt producing bacteria in AAs which are stimulated by high animal fat diets to produce carcinogenic secondary bile ..
- New pathways regulating bile acid homeostasis and cholestatic liver diseasesLi Wang; Fiscal Year: 2013DESCRIPTION (provided by applicant): The conversion to bile acids represents a major pathway for cholesterol elimination from the body, which is therefore of critical importance in maintaining cholesterol homeostasis...
- Biliary Atresia, Cholestatic Liver Diseases, and Cystic Fibrosis: Indiana UniversJean Pappas Molleston; Fiscal Year: 2013..Alagille's syndrome, alpha-1-antitrypsin deficiency, Progressive Familial Intrahepatic Cholestasis (PFIC), bile acid synthetic defects, mitochondrial hepatopathies, and cystic fibrosis...
- Regulation of Bile Acid Synthesis by Nuclear Receptors in VivoGregorio Gil; Fiscal Year: 2012b>Bile acids are required for intestinal absorption and biliary solubilization of cholesterol and lipids. In addition, bile acids play a crucial role in cholesterol homeostasis...
- Gallstone Pancreatitis: Pathogenesis and TreatmentIsaac Samuel; Fiscal Year: 2012Gallstone pancreatitis is common and is potentially fatal. Enteral exclusion of bile-pancreatic juice by the stone causes feedback hyperstimulation of the exocrine pancreas that induces pancreatic overproduction of acute inflammatory ..
- DYSREGULATION OF GSH SYNTHESIS DURING LIVER INJURY AND FIBROSISSHELLY CHI LOO LU; Fiscal Year: 2013..They will complement in vivo studies in mice treated with bile duct ligation or LPS...
- Colorado Center for Childhood Liver Disease Research and EducationRonald J Sokol; Fiscal Year: 2013..In cholestasis, impairment of bile flow leads to the accumulation of hepatotoxic bile acids, cholesterol and other compounds that produce liver injury ..
- MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORTBenjamin L Shneider; Fiscal Year: 2012DESCRIPTION (provided by applicant): The apical sodium-dependent bile acid transporter (ASBT) is the major carrier protein involved in intestinal reclamation of bile salts...
- Mouse models for esophageal Cox-2 oxidative stress and DNA damageJohn P Lynch; Fiscal Year: 2013..It occurs in response to chronic acid and bile reflux and is an important risk factor for the development of esophageal adenocarcinoma (EAC)...
- The Pittsburgh Cholestatic Liver Disease ConsortiumBenjamin L Shneider; Fiscal Year: 2013Neonatal cholestatic liver diseases including Alagille syndrome, alpha-1 antitrypsin deficiency, bile acid synthesis defects, biliary atresia, cystic fibrosis, mitochondrial hepatopathies and progressive familial intrahepatic cholestasis,..
- Molecular &Cellular Effects of Human Mutations in Cytochrome P450 ReductaseSatya Prakash Panda; Fiscal Year: 2013..a large family of enzymes responsible for such diverse reactions as drug and xenobiotic metabolism, steroid and bile acid biosynthesis, and fatty acid and eicosanoid hydroxylation...
- GI-Safer Formulation of Indomethacin for use in Preterm NeonatesUPENDRA K MARATHI; Fiscal Year: 2013..Also, during weaning there were developmentally increasing levels of both intestinal bile acid and ileal bile acid uptake transporter (apical sodium-dependent bile acid transporter, ASBT) which may be ..
- Regulation of Bacteroides fragilis multidrug efflux pumpsHannah Wexler; Fiscal Year: 2013..and in resistance could be induced by a variety of agents and stressors including antimicrobials, salicylate, bile and quorum sensing molecules...
- Breakthroughs to advance the in vitro propagation of human norovirusesQiuhong Wang; Fiscal Year: 2010..propagate HuNoVs in vitro include: 1) Mediators in the intestinal micro-environment (intestinal content filtrates, bile acids) that promote in vitro replication of porcine SaV;2) Role of innate immunity in inhibiting murine NoV (MNV) ..
- The Role of Cyp2b in Toxicant Metabolism and SensitivityWilliam S Baldwin; Fiscal Year: 2012..cytochrome P450s (CYPs) are key enzymes involved in the detoxification of numerous chemicals including steroids, bile acids, pharmaceuticals, and environmental chemicals...
- Translational Research and Evolving Alcoholic hepatitis Treatment (TREAT-IU)David W Crabb; Fiscal Year: 2013..understand its pathogenesis and to develop novel treatments, and (b) alcohol-induced impairment of signaling via bile salt receptors impairs gut integrity, permits activation of Kupffer cells, enhances oxidative stress in the liver, ..
- Epigenetic regulation of liver transportersFrederick J Suchy; Fiscal Year: 2013..recruitment of coregulators associated with ligand-induced activation of FXR, a prototypical nuclear receptor for bile acids, regulate the expression of liver transport proteins in the normal liver and during cholestasis...
- Functions of the Human OST-alpha and OST-beta ProteinsPatricia M Hinkle; Fiscal Year: 2013..to advance understanding of mechanisms of disposition of the two major classes of cholesterol metabolites, namely bile acids and steroid conjugates, compounds that play important roles in a number of biological processes and human ..
- The Role of Leptin in Liver FibrogenesisFrank A Anania; Fiscal Year: 2012..We will use Ad -/- mice subjected to either CCl4 or common bile-duct ligation (CBDL) for induction of fibrosis and administer recombinant adiponectin...
- CELLS PROCESSING HIGH DENSITY LIPOPROTEINSSalman Azhar; Fiscal Year: 2013..route for the delivery of CEs to the liver and steroidogenic tissues of rodents and humans for the biosynthesis of bile acids and steroid hormones, respectively...
- Thyroid-adrenergic synergism and adaptive thermogenesisAntonio C Bianco; Fiscal Year: 2013..these mechanisms can be modulated by a wide variety of signaling molecules such as the hedgehog family of proteins, bile acids, HIF-1, NF-B, and a number of xenobiotic substances...
- The role of regulatory T cells in biliary atresiaAlexander Miethke; Fiscal Year: 2013..lymphocytes and attenuated the BA phenotype, as evidenced by lower serum bilirubin levels and reduced inflammatory bile duct obstruction...
- Crosstalk between estrogen and bile acid signaling pathwayRuitang Deng; Fiscal Year: 2013..b>Bile acids are metabolites of cholesterol and have been identified as a class of signaling molecules for nuclear ..
- A Microfluidic-platform Mini-Liver System for Human Liver Biology StudiesHONGSEOK M NOH; Fiscal Year: 2010..develop a simple hepatocyte/collagen/LSEC sandwiched configuration and then expand this to include a channel for bile removal and, if necessary, additional sinusoid resident cells such as Kupffer or stellate cells...
- Treatment of Acute Coronary Syndromes with Recombinant LCAT InfusionBRIAN ROBERT KRAUSE; Fiscal Year: 2011..Normally, cholesterol is removed from arteries and delivered to the liver for excretion into bile by a multistep process known as "Reverse Cholesterol Transport" (RCT)...
- Vibrio cholerae-host interaction at the Intestinal InterfaceJun Zhu; Fiscal Year: 2013..We have successfully purified and identified VIF-1 as taurocholic acid, a bile acid. Preliminary studies suggest that VIF-1 enhances the activity of TcpP...
- USC Research Center for Liver DiseaseNeil Kaplowitz; Fiscal Year: 2013..Current projects include studies of: a) farnesoid X receptor, bile acids and liver regeneration;b) the role of Myc-max and Mnt-max in regulation of p53 and cyclin D1 by toxic bile ..
- The Role of Fibrocytes in Liver FibrosisTatiana Kisseleva; Fiscal Year: 2012..signals in the course of liver fibrosis using two models of liver injury, carbontetrachloride (CCl4 and bile duct ligation (BDL). We anticipate that fibrocytes play an important role in pathogenesis of liver fibrosis (AIM 1)...
- (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon CancerYan Chun Li; Fiscal Year: 2013..Secondary bile acids (BA) are potent colon cancer promoters...
- Role of liver fluke granulin in cholangiocarcinogenesisJason P Mulvenna; Fiscal Year: 2013..parasites Opisthorchis viverrini and Clonorchis sinensis is a strong risk factor for cholangiocarcinoma (CCA), bile duct cancer, in Thailand, Laos and other locations in East Asia where infection is endemic...
- Extracellular Replication of Listeria in VivoChristopher H Contag; Fiscal Year: 2010..The major bile resistance locus bilE is dispensable for replication in the gallbladder...
- Participation in Cytochrome b5 in Anesthetic MetabolismLucy A Waskell; Fiscal Year: 2010..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
- Role of FoxO1 in Lipid MetabolismREBECCA ANNE HAEUSLER; Fiscal Year: 2013..In preliminary data, I demonstrate a heretofore unknown link between the canonical Akt-FoxO pathway, bile acid (BA) composition, and lipid synthesis...
- Regulation of cholesterol catabolism by bile acidsJongsook Kim Kemper; Fiscal Year: 2013DESCRIPTION (provided by applicant): The overall goal of this project is to understand the role of bile acids as recently recognized key signaling molecules that control integrative metabolism and energy balance and the dysfunction of ..
- Structural Biology of the Apical Bile Acid Transporter.Peter W Swaan; Fiscal Year: 2012DESCRIPTION (provided by applicant): The apical sodium-dependent bile acid transporter (ASBT) plays a key role in the enterohepatic recycling of bile salts, cholesterol homeostasis, and serves as a molecular target for ..
- MOLECULAR BIOLOGY OF BILE ACID SYNTHESISJOHN CHIANG; Fiscal Year: 2009Project Summary Bile acids are physiological detergents that generate bile flow and facilitate intestine absorption and transport of lipids, nutrients and vitamins...
- The Role of Genetics in Innate Immunity Following CholestasisSamuel M Alaish; Fiscal Year: 2011..A description of the research project follows: Defined as little or no bile flow, cholestasis is a common condition associated with significant and sometimes devastating complications in both ..
- Regulation of Hepatic Metabolic Function by Parenteral NutritionDouglas G Burrin; Fiscal Year: 2013..We will use in vivo metabolic (13C-bile acid turnover and 13C-palmitate oxidation kinetics) and liver transcriptomic and metabolomic approaches to ..
- Heme trafficking and its impact on systemic iron homeostasisJanis L Abkowitz; Fiscal Year: 2010..to liver by studying Flvcrflox/flox;alb-cre mice; determine if hepatocytes can secrete heme via FLVCR into the bile permitting iron to exit the body;and explore the implications of these findings in models of hemolysis, chronic ..
- ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSISJOHN GRIDER; Fiscal Year: 2009..Release of BDNF will be determined in response to physiological stimuli (mucosal stroking, free fatty acids, and bile salts), to neurotransmitters (CGRP and SP), and to paracrine agents (5-HT and endocannabinoids) known to mediate or ..
- Structure/Function of Steroid Transforming AKR'sTrevor M Penning; Fiscal Year: 2011..a first step in the elimination of steroid hormones, and an essential step in the synthesis of all bile-acids...
- Heme trafficking and its impact on systemic iron homeostasisJanis L Abkowitz; Fiscal Year: 2013..to liver by studying Flvcrflox/flox;alb-cre mice;determine if hepatocytes can secrete heme via FLVCR into the bile permitting iron to exit the body;and explore the implications of these findings in models of hemolysis, chronic ..
- MOLECULAR BIOLOGY OF BILE ACID SYNTHESISJohn Y L Chiang; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bile acids are physiological detergents that generate bile flow and facilitate intestine absorption and transport of lipids, nutrients and vitamins...
- Bile Acids, Genetic Control and Colonic Function in Irritable Bowel SyndromeMICHAEL L CAMILLERI; Fiscal Year: 2013..The etiological factors that impact on all these functions include endogenous substances, like bile acids (BA)...
- Characterization of Diet1, a hypercholesterolemia resistance geneKaren Reue; Fiscal Year: 2013..Diet1 is expressed in the small intestinal epithelial cells, and we hypothesize that it functions in intracellular bile acid transport...
- REGULATION OF BILE ACID SYNTHESISJOHN CHIANG; Fiscal Year: 1999The conversion of cholesterol to bile acids in the liver is the major pathway for the catabolism of cholesterol and plays an important role in the maintenance of cholesterol homeostasis...
- Bile acid-induced colon cancer cell proliferationJean Pierre Raufman; Fiscal Year: 2009The central hypothesis to be tested in this proposal is that bile acids induce colon cancer cell proliferation by interaction with M3 muscarinic receptors (M3R), thereby causing transactivation of epidermal growth factor receptors (EGFR)...
- INTRACELLULAR TRANSPORT OF AMPHIPATHSBruce Luxon; Fiscal Year: 2000..the mechanism underlying the cytoplasmic transport of amphipathic molecules like long-chain fatty acids and bile acids...
- Understanding the role of bile as a mechanism for improved glucose homeostasis foAPRIL DAWN STRADER; Fiscal Year: 2010..result in the resolution of type-II diabetes is the exposure of the lower intestine to higher concentrations of bile salts. As mentioned above, the interposed ileum is exposed to high concentrations of biliopancreatic secretions...
- PHYSICAL CHEMISTRY OF BILIRUBIN & ITS CONJUGATESWILLIAM SPIVAK; Fiscal Year: 1990..gallstones and are essential parts of the matrix of pigment gallstones, biliary sludge and the insoluble bile pigment precipitates which clog the bile ductules and canaliculi of patients with cholestatic liver disease...
- EFFECTS OF BILE ACIDS ON CALCIUM AND IRON ABSORPTIONEdward Moore; Fiscal Year: 1990Several previous studies have shown that whole bile and/or bile salts enhance absorption of both iron and calcium...
- URSODIOL-METHOTREXATE FOR PRIMARY BILIARY CIRRHOSISBurton Combes; Fiscal Year: 2003..PBC is a chronic cholestatic liver disease, predominantly of women, in which interlobular and septal bile ducts undergo inflammation and destruction. Once initiated, the disease persists and progresses at varying rates...
- MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETIONDavid Cohen; Fiscal Year: 2000b>Bile is the principal pathway for cholesterol elimination from the body, and abnormalities in bile secretion may result in gallstone formation, cholestasis, biliary cirrhosis, hypercholesterolemia and fat malabsorption...
- NEURAL CONTROL OF THE GALLBLADDERGary M Mawe; Fiscal Year: 2010..reports suggest that decreased gallbladder motility is caused by elevated cholesterol and hydrophobic salts in the bile, and that ensuing inflammation and impairments in gallbladder emptying lead to stone formation...
- HEPATIC DRUG ELIMINATION IN PREGNANCYMary Vore; Fiscal Year: 2010..transporter that mediates the biliary excretion of glucuronide and glutathione conjugates from the hepatocyte into bile. The proposal builds on our findings that 1) MRP2 transports tauroursodeoxycholate (TUDC), a bile acid used for the ..
- HEPATIC DRUG ELIMINATION IN PREGNANCYMary Vore; Fiscal Year: 2007..transporter that mediates the biliary excretion of glucuronide and glutathione conjugates from the hepatocyte into bile. The proposal builds on our findings that 1) MRP2 transports tauroursodeoxycholate (TUDC), a bile acid used for the ..