Summary: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.

Top Publications

  1. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
  2. ncbi Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    Sunil R Hingorani
    Department of Medicine, Abramson Family Cancer Research Institute, Abramson Center at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 4:437-50. 2003
  3. pmc Generation and regeneration of cells of the liver and pancreas
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 322:1490-4. 2008
  4. pmc On the origin of the beta cell
    Jennifer M Oliver-Krasinski
    Institute for Diabetes, Obesity and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 22:1998-2021. 2008
  5. ncbi Induction of pancreatic differentiation by signals from blood vessels
    E Lammert
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 294:564-7. 2001
  6. doi Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet
    Vanessa Souza-Mello
    Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, 20551 030 Rio de Janeiro, RJ, Brazil
    Clin Sci (Lond) 119:239-50. 2010
  7. ncbi Genetics and biology of pancreatic ductal adenocarcinoma
    Aram F Hezel
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Genes Dev 20:1218-49. 2006
  8. doi Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    Kenichiro Furuyama
    Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nat Genet 43:34-41. 2011
  9. doi Pancreas organogenesis: from bud to plexus to gland
    Fong Cheng Pan
    Dev Dyn 240:530-65. 2011
  10. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003

Detail Information

Publications400 found, 100 shown here

  1. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    In the mammalian pancreas, the endocrine cell types of the islets of Langerhans, including the alpha-, beta-, delta-, and pancreatic polypeptide cells as well as the exocrine cells, derive from foregut endodermal progenitors...
  2. ncbi Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    Sunil R Hingorani
    Department of Medicine, Abramson Family Cancer Research Institute, Abramson Center at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 4:437-50. 2003 pancreatic tumorigenesis, we directed endogenous expression of KRAS(G12D) to progenitor cells of the mouse pancreas. We find that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of ..
  3. pmc Generation and regeneration of cells of the liver and pancreas
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 322:1490-4. 2008
    Liver and pancreas progenitors develop from endoderm cells in the embryonic foregut. Shortly after their specification, liver and pancreas progenitors rapidly acquire markedly different cellular functions and regenerative capacities...
  4. pmc On the origin of the beta cell
    Jennifer M Oliver-Krasinski
    Institute for Diabetes, Obesity and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 22:1998-2021. 2008
    ..Realizing the potential for cell-based therapies, however, requires a thorough understanding of pancreas development and beta-cell formation...
  5. ncbi Induction of pancreatic differentiation by signals from blood vessels
    E Lammert
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 294:564-7. 2001
    ..These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development...
  6. doi Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet
    Vanessa Souza-Mello
    Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, 20551 030 Rio de Janeiro, RJ, Brazil
    Clin Sci (Lond) 119:239-50. 2010
    ..The best results were achieved using telmisartan and sitagliptin as monotherapies or as a dual treatment, combining partial PPAR-gamma agonism and PPAR-alpha activation in the liver with extended incretin action...
  7. ncbi Genetics and biology of pancreatic ductal adenocarcinoma
    Aram F Hezel
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Genes Dev 20:1218-49. 2006
    ..This confluence of developments offers the opportunity for accelerated discovery and the future promise of improved treatment...
  8. doi Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    Kenichiro Furuyama
    Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nat Genet 43:34-41. 2011
    The liver and exocrine pancreas share a common structure, with functioning units (hepatic plates and pancreatic acini) connected to the ductal tree...
  9. doi Pancreas organogenesis: from bud to plexus to gland
    Fong Cheng Pan
    Dev Dyn 240:530-65. 2011
    b>Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a step-wise process of organ development from early bud specification all the way to the final mature ..
  10. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
    Genes encoding homeodomain-containing proteins potentially involved in endocrine pancreas development were isolated by combined in silico and nested-PCR approaches...
  11. pmc Mechanisms of action of glucagon-like peptide 1 in the pancreas
    Maire E Doyle
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA
    Pharmacol Ther 113:546-93. 2007
    ..guanine nucleotide-binding protein (G-protein) coupled receptor (GPCR) that is present in tissues other than the pancreas (brain, kidney, lung, heart, and major blood vessels)...
  12. pmc The human GLP-1 analog liraglutide and the pancreas: evidence for the absence of structural pancreatic changes in three species
    Niels C B Nyborg
    Department of Nonclinical Development Management, Novo Nordisk, Bagsværd, Denmark
    Diabetes 61:1243-9. 2012
    ..In conclusion, liraglutide did not induce pancreatitis in mice, rats, or monkeys when dosed for up to 2 years and at exposure levels up to 60 times higher than in humans...
  13. pmc Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats
    Wan Chun Li
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 123:2792-802. 2010
    The adult pancreas has considerable capacity to regenerate in response to injury...
  14. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
  15. pmc The pancreatic stellate cell: a star on the rise in pancreatic diseases
    M Bishr Omary
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Clin Invest 117:50-9. 2007
    Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the pancreas that have exocrine function...
  16. ncbi Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    Carmen Guerra
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, E 28029 Madrid, Spain
    Cancer Cell 11:291-302. 2007
    ..These observations suggest that, during adulthood, PDA stems from a combination of genetic (e.g., somatic K-Ras mutations) and nongenetic (e.g., tissue damage) events...
  17. pmc Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
    Alexandra E Butler
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Diabetes 62:2595-604. 2013
  18. ncbi Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function
    Marcela Brissova
    Division of Diabetes, Endocrinology, and Metabolism, 715 PRB, Vanderbilt University, Nashville, TN 37232, USA
    Diabetes 55:2974-85. 2006
    ..Factors modulating VEGF-A expression may influence islet vascularity and, consequently, the amount of insulin delivered into the systemic circulation...
  19. pmc Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
    Juris J Meier
    Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7073, USA
    Diabetes 57:1584-94. 2008
    ..We also sought to establish if there is a secondary growth in beta-cell mass coincident with the accelerated somatic growth in adolescence...
  20. pmc Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
    F J Naya
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 11:2323-34. 1997
    ..The nervous system appeared to develop normally, despite abundant expression of BETA2 in differentiating neurons. Thus, BETA2 is critical for the normal development of several specialized cell types arising from the gut endoderm...
  21. pmc No evidence for β cell neogenesis in murine adult pancreas
    Xiangwei Xiao
    Division of Pediatric Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    J Clin Invest 123:2207-17. 2013
    Whether facultative β cell progenitors exist in the adult pancreas is a major unsolved question. To date, lineage-tracing studies have provided conflicting results...
  22. doi Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice
    G da Silva Xavier
    Section of Cell Biology, Division of Diabetes, Department of Medicine, Imperial College London, London SW7 2AZ, UK
    Diabetologia 55:2667-76. 2012
    ..Here, we sought to determine whether selective deletion of Tcf7l2 in mouse pancreas impairs insulin release and glucose homeostasis.
  23. pmc Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development
    Elayne Provost
    Department of Surgery, Johns Hopkins University, Baltimore, MD 21205, USA
    Development 139:3232-41. 2012
    ..The pancreatic phenotypes observed in rpl3- and pes-deficient embryos were also independent of p53. Together, these data suggest novel p53-independent roles for ribosomal biogenesis genes in zebrafish pancreas development.
  24. pmc Gene regulatory networks governing pancreas development
    H Efsun Arda
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Dev Cell 25:5-13. 2013
    ..Here, we have compiled reference GRNs underlying pancreas development from data mining that integrates multiple approaches, including mutant analysis, lineage tracing, ..
  25. pmc Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis
    Shouhong Xuan
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3516-28. 2012
    Pancreatic agenesis is a human disorder caused by defects in pancreas development...
  26. pmc Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells
    M Cristina Nostro
    McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada
    Development 138:861-71. 2011
    ..Optimal stage-specific manipulation of these pathways resulted in a striking 250-fold increase in the levels of insulin expression and yielded populations containing up to 25% C-peptide+ cells...
  27. doi Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes Metab Res Rev 26:200-5. 2010
    ..The aim was to thoroughly quantify the fat content of pancreas sections (caput, corpus, and cauda) and to compare the impact of pancreatic, intrahepatic, and visceral fat on ..
  28. doi Pancreatic beta-cell mass in European subjects with type 2 diabetes
    J Rahier
    Department of Pathology, Faculty of Medicine, University of Louvain, Brussels, Belgium
    Diabetes Obes Metab 10:32-42. 2008
    ..Here, we quantified the beta-cell mass in pancreas obtained at autopsy of 57 type 2 diabetic (T2D) and 52 non-diabetic subjects of European origin...
  29. ncbi MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
    The generation of distinct cell types during the development of the pancreas depends on sequential changes in gene expression...
  30. pmc Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate
    Georgios Kallifatidis
    Molecular OncoSurgery, University of Heidelberg, Heidelberg, Germany
    Mol Ther 19:188-95. 2011
    ..No pronounced side effects were observed in normal cells or mice. Our data suggest that SF increases the effectiveness of various cytotoxic drugs against CSCs without inducing additional toxicity in mice...
  31. doi Nuclear expression of interleukin-33 in pancreatic stellate cells
    Atsushi Masamune
    Tohoku Univ Graduate School of Medicine, Sendai, Japan
    Am J Physiol Gastrointest Liver Physiol 299:G821-32. 2010
    ..PSCs were isolated from human and rat pancreas tissues. The expression of IL-33 was examined by Western blotting, PCR, ELISA, and immunostaining...
  32. doi International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Pancreatology 12:183-97. 2012
    ..guidelines for management of intraductal papillary mucinous neoplasm and mucinous cystic neoplasm of the pancreas established in 2006 have increased awareness and improved the management of these entities...
  33. pmc Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    Nabeel Bardeesy
    Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 20:3130-46. 2006
    ..Here, using genetically engineered mice, we determined the impact of SMAD4 deficiency on the development of the pancreas and on the initiation and/or progression of PDAC-alone or in combination with PDAC--relevant mutations...
  34. ncbi Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
    M Sander
    Hormone Research Institute, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Development 127:5533-40. 2000
    Most insulin-producing beta-cells in the fetal mouse pancreas arise during the secondary transition, a wave of differentiation starting at embryonic day 13. Here, we show that disruption of homeobox gene Nkx6...
  35. ncbi Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    Guoqiang Gu
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 129:2447-57. 2002
    ..5 (E9.5-E11.5). These findings suggest that lineages for exocrine, endocrine islet and duct progenitors are committed at mid-gestation...
  36. ncbi Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells
    Manami Hara
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Am J Physiol Endocrinol Metab 284:E177-83. 2003
    ..We prepared single-cell suspensions from both isolated islets and whole pancreas from MIP-GFP-transgenic mice and sorted the beta-cells by fluorescence-activated cell sorting based on their ..
  37. ncbi The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation
    Ganka Nikolova
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Dev Cell 10:397-405. 2006
    ..The proposed mechanism explains why beta cells must interact with endothelial cells, and it may apply to other cellular processes in which endothelial signals are required...
  38. pmc Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
    Catherine L Prado
    Department of Pediatrics, Barbara Davis Center, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:2924-9. 2004
    ..Intriguingly, normal mouse pancreas also contains a small population of ghrelin-producing cells, defining a new islet "epsilon" cell population...
  39. ncbi The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death
    H Putaala
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Hum Mol Genet 10:1-8. 2001
    ..In addition to expression in glomerular podocytes, the reporter gene was expressed in the brain and pancreas of (+/-) and (-/-) mice...
  40. pmc Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    Janel L Kopp
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 138:653-65. 2011
    One major unresolved question in the field of pancreas biology is whether ductal cells have the ability to generate insulin-producing β-cells...
  41. doi Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas
    J S Nachnani
    Division of Gastroenterology and Hepatology, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Diabetologia 53:153-9. 2010
    ..Previous studies have evaluated the effect of exendin-4 on beta cells and beta cell function. We evaluated the histological and biochemical effects of exendin-4 on the pancreas in rats.
  42. pmc PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L
    Thomas M Beres
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Mol Cell Biol 26:117-30. 2006
    PTF1 is a trimeric transcription factor essential to the development of the pancreas and to the maintenance of the differentiated state of the adult exocrine pancreas...
  43. pmc Notch signaling controls multiple steps of pancreatic differentiation
    L Charles Murtaugh
    Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:14920-5. 2003
    Multiple cell types of the pancreas appear asynchronously during embryogenesis, which requires that pancreatic progenitor cell potential changes over time...
  44. pmc Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase
    Harshan Pisharath
    Department of Comparative Medicine, Johns Hopkins School of Medicine, 720 Rutland Avenue, Ross 771, Baltimore, MD 21205, USA
    Mech Dev 124:218-29. 2007
    ..ptf1a morphants, it is clear that this beta cell recovery occurs independently of the presence of the exocrine pancreas. Also, by using photoconvertible Kaede to cell lineage trace and BrdU incorporation to label proliferation, we ..
  45. pmc Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents
    Krystyna Tatarkiewicz
    Amylin Pharmaceuticals, San Diego, CA, USA
    Am J Physiol Endocrinol Metab 299:E1076-86. 2010
    ..In conclusion, exenatide did not modify plasma amylase and lipase concentrations in rodents without pancreatitis and improved chemically induced pancreatitis in normal and diabetic rodents...
  46. ncbi Insulin-promoter-factor 1 is required for pancreas development in mice
    J Jonsson
    Department of Microbiology, University of Umea, Sweden
    Nature 371:606-9. 1994
    The mammalian pancreas is a mixed exocrine and endocrine gland that, in most species, arises from ventral and dorsal buds which subsequently merge to form the pancreas...
  47. doi A step-up approach or open necrosectomy for necrotizing pancreatitis
    Hjalmar C van Santvoort
    University Medical Center, Utrecht, The Netherlands
    N Engl J Med 362:1491-502. 2010
    ..Necrotizing pancreatitis with infected necrotic tissue is associated with a high rate of complications and death. Standard treatment is open necrosectomy. The outcome may be improved by a minimally invasive step-up approach...
  48. ncbi Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion
    Amanda M Ackermann
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Mol Endocrinol 38:193-206. 2007
  49. doi Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth
    Myriam Solar
    Genomic Programming of Beta Cells Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    Dev Cell 17:849-60. 2009
    ..We show that Hnf1beta+ cells of the trunk compartment of the early branching pancreas are precursors of acinar, duct, and endocrine lineages...
  50. ncbi The biology of incretin hormones
    Daniel J Drucker
    Department of Medicine, The Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario M5G 2C4, Canada
    Cell Metab 3:153-65. 2006
    ..This article summarizes current concepts of incretin action and highlights the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes...
  51. ncbi Minireview: transcriptional regulation in pancreatic development
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, 55 Fruit Street, WEL320, Boston, Massachusetts 02114, USA
    Endocrinology 146:1025-34. 2005
    ..of the sequential activation of signal transduction pathways and the expression of transcription factors during pancreas development...
  52. doi Pancreatic stellate cells: partners in crime with pancreatic cancer cells
    Alain Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School, The University of New South Wales, Sydney, New South Wales 2052, Australia
    Cancer Res 68:2085-93. 2008
    ..Our studies indicate a significant interaction between pancreatic cancer cells and stromal cells (PSCs) and imply that pancreatic cancer cells recruit stromal cells to establish an environment that promotes cancer progression...
  53. pmc An improved protocol for optical projection tomography imaging reveals lobular heterogeneities in pancreatic islet and β-cell mass distribution
    Andreas Hörnblad
    Umeå Centre for Molecular Medicine, Umea University, Umea, Sweden
    Islets 3:204-8. 2011
    ..extract information of the spatial and quantitative distribution of the islets of Langerhans in the intact mouse pancreas. In order to further increase the sensitivity of OPT imaging for this type of assessment, we have developed a ..
  54. doi Contribution of postnatally formed small beta cell aggregates to functional beta cell mass in adult rat pancreas
    M Chintinne
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090, Brussels, Belgium
    Diabetologia 53:2380-8. 2010
    ..We investigated the contribution of postnatally formed small aggregates to functional beta cell mass in adult rats...
  55. doi A prospective evaluation of fatty pancreas by using EUS
    Paul S Sepe
    Division of Gastroenterology, Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastrointest Endosc 73:987-93. 2011
    Fatty liver is associated with obesity, diabetes, hyperlipidemia, and the metabolic syndrome. The pathophysiology of fatty pancreas is poorly understood, but it may be closely related to fatty liver.
  56. pmc Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
    Pierre Paul Prevot
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, B 1200 Brussels, Belgium
    Gut 61:1723-32. 2012
    ..In this study, the role of the ductal transcription factors hepatocyte nuclear factor 6 (HNF6, also known as Onecut1) and SRY-related HMG box factor 9 (Sox9) in ADM was investigated...
  57. doi Ganglionar nervous cells and telocytes in the pancreas of Octodon degus: extra and intrapancreatic ganglionar cells and telocytes in the degus
    Cleofina Bosco
    Programa de Anatomía y Biología del Desarrollo, ICBM, Facultad de Medicina, Universidad de Chile, Chile Electronic address
    Auton Neurosci 177:224-30. 2013
    ..extrapancreatic ganglionar neurons and telocytes in Octodon degus such as those described in human and guinea pig pancreas. Pancreatic ganglionar neurons were identified by their histological characteristics as well as their positive ..
  58. doi Expression of islet-specific microRNAs during human pancreatic development
    Mugdha V Joglekar
    Stem Cells and Diabetes Section, Lab 12, National Center for Cell Science, Ganeshkhind Road, Pune, MH 411007, India
    Gene Expr Patterns 9:109-13. 2009
    ..changes in gene expression are known to be necessary for efficient differentiation and function of the endocrine pancreas. Several studies till now have demonstrated that microRNAs (miRNAs), which regulate translation of gene ..
  59. ncbi Generation of insulin-producing islet-like clusters from human embryonic stem cells
    Jianjie Jiang
    Cell Therapy Research, Geron Corporation, Menlo Park, CA 94025, USA
    Stem Cells 25:1940-53. 2007
    ..The temporal pattern of pancreas-specific gene expression in the hESC-derived ILCs showed considerable similarity to in vivo pancreas development, ..
  60. pmc Tissue-specific alternative splicing of TCF7L2
    Ludmila Prokunina-Olsson
    Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 18:3795-804. 2009
    ..survey mRNA expression of multiple TCF7L2 splicing forms in up to 380 samples from eight types of human tissue (pancreas, pancreatic islets, colon, liver, monocytes, skeletal muscle, subcutaneous adipose tissue and lymphoblastoid cell ..
  61. pmc EGF receptor is required for KRAS-induced pancreatic tumorigenesis
    Christine M Ardito
    Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA
    Cancer Cell 22:304-17. 2012
    ..However, PDA mouse models show that mutant Kras expression early in development gives rise to a normal pancreas, with tumors forming only after a long latency or pancreatitis induction...
  62. ncbi Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals, NSW, Sydney, Australia
    Pancreas 29:179-87. 2004
  63. doi Chronic pancreatitis
    Joan M Braganza
    Department of Gastroenterology, Manchester Royal Infirmary, Manchester, UK
    Lancet 377:1184-97. 2011
    ..Steatorrhoea, diabetes, local complications, and psychosocial issues associated with the disease are additional therapeutic challenges...
  64. ncbi Mutations in PTF1A cause pancreatic and cerebellar agenesis
    Gabrielle S Sellick
    Section of Cancer Genetics, Institute of Cancer Research, Surrey SM2 5NG, UK
    Nat Genet 36:1301-5. 2004
    ..Positional cloning identified the mutations 705insG and C886T in the gene PTF1A, encoding pancreas transcription factor 1alpha, as disease-causing sequence changes...
  65. doi The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
    M Cnop
    Laboratory of Experimental Medicine and Division of Endocrinology, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetologia 53:321-30. 2010
    ..Intracellular lipofuscin body (LB) accumulation is a hallmark of ageing in neurons. To estimate the lifespan of human beta cells, we measured beta cell LB accumulation in individuals aged 1-81 years...
  66. doi Developmental biology of the pancreas: a comprehensive review
    George K Gittes
    Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Department of Pediatric Surgery, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Dev Biol 326:4-35. 2009
    ..of pancreatic development, though still there is not a room for discussion of stem cell differentiation to pancreas, nor for discussion of post-natal regeneration phenomena, two important fields closely related to pancreatic ..
  67. ncbi Dissecting the role of glucocorticoids on pancreas development
    Emilie Gesina
    INSERM U457, Hopital Robert Debre, Paris F 75019, France
    Diabetes 53:2322-9. 2004
    To determine whether glucocorticoids are involved in pancreas development, glucocorticoid treatment of rat pancreatic buds in vitro was combined with the analysis of transgenic mice lacking the glucocorticoid receptor (GR) in specific ..
  68. ncbi MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
    Mark Bloomston
    Division of Surgical Oncology, James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, USA
    JAMA 297:1901-8. 2007
    While global microRNA (miRNA) expression patterns of many embryologic, physiologic, and oncogenic processes have been described, description of the role of miRNAs in ductal adenocarcinoma of the pancreas is lacking.
  69. ncbi Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
    A recent study has shown that deletion of beta-catenin within the pancreatic epithelium results in a loss of pancreas mass...
  70. ncbi The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    Yoshiya Kawaguchi
    Vanderbilt Developmental Biology Program, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232 2175, USA
    Nat Genet 32:128-34. 2002
    b>Pancreas development begins with the formation of buds at specific sites in the embryonic foregut endoderm...
  71. ncbi Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
    Jan Nygaard Jensen
    Barbara Davis Center for Childhood Diabetes, U Colorado, HSC, 4200 E 9th Avenue, B140, Denver, Colorado 80262 USA
    Gastroenterology 128:728-41. 2005
    The mammalian pancreas has a strong regenerative potential, but the origin of organ restoration is not clear, and it is not known to what degree such a process reflects pancreatic development...
  72. ncbi Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro
    Masaaki Nakai
    Institute for Health Care Science and Suntory Institute for Bioorganic Research, Suntory, Ltd, 1 1 1 Wakayamadai, Osaka 618 8503, Japan
    J Agric Food Chem 53:4593-8. 2005
    ..38 microg/mL). These data suggested that the presence of galloyl moieties within their chemical structures and/or the polymerization of flavan-3-ols were required for enhancement of pancreatic lipase inhibition...
  73. ncbi A brain-liver circuit regulates glucose homeostasis
    Alessandro Pocai
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Metab 1:53-61. 2005
    ..This crosstalk between brain and liver couples central nutrient sensing to peripheral nutrient production and its disruption may lead to hyperglycemia...
  74. ncbi Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue
    Ilse Rooman
    Cell Differentiation Group, Diabetes Research Center, Free University of Brussels VUB, Brussels, Belgium
    Diabetes 51:686-90. 2002
    ..We evaluated the role of intravenously infused gastrin in regenerating pancreas of duct-ligated rats...
  75. ncbi Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth
    Miguel Angel Maestro
    Genomic Programming of Beta Cells Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, Endocrinology, Hospital Clinic de Barcelona, Barcelona, Spain
    Endocr Dev 12:33-45. 2007
    ..what we have learnt during recent years concerning the functions of these regulators in the developing and adult pancreas. Mouse studies have revealed that HNF1beta is a critical regulator of a transcriptional network that controls the ..
  76. ncbi Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
    K A Harrison
    Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 23:71-5. 1999
    In most mammals the pancreas develops from the foregut endoderm as ventral and dorsal buds. These buds fuse and develop into a complex organ composed of endocrine, exocrine and ductal components...
  77. pmc GATA6 haploinsufficiency causes pancreatic agenesis in humans
    Hana Lango Allen
    Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    Nat Genet 44:20-2. 2012
    ..These findings define the most common cause of human pancreatic agenesis and establish a key role for the transcription factor GATA6 in human pancreatic development...
  78. pmc Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
    Meritxell Huch
    Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Utrecht, The Netherlands
    EMBO J 32:2708-21. 2013
    ..Wnt signalling is inactive and Lgr5 is not expressed under physiological conditions in the adult pancreas. However, we now report that the Wnt pathway is robustly activated upon injury by partial duct ligation (PDL), ..
  79. pmc Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis
    Jingjing Zhang
    Metabolic Syndrome Research Center, Diabetes Center, Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Diabetes 61:3189-98. 2012
    ..In this study, we show that pancreas-specific knockout of growth factor receptor-binding protein 10 (Grb10), which is highly expressed in pancreas and ..
  80. ncbi Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
    Anna L Means
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 132:3767-76. 2005
    ..In both mouse and human pancreas, acinar-to-ductal metaplasia has been implicated in the generation of cancer precursors...
  81. ncbi Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas
    Grace E Kim
    Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Gastroenterology 123:1052-60. 2002
    It has recently been suggested that infiltrating adenocarcinoma of the pancreas arises from histologically well-defined precursor ductal lesions called pancreatic intraepithelial neoplasia (PanIN-1A, -1B, -2, and -3)...
  82. doi Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies
    Dimitrios P Bogdanos
    Institute of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, King s College London School of Medicine at King s College Hospital, London, UK
    Autoimmun Rev 11:143-8. 2011
    Pancreatic autoantibodies (PAB) giving characteristic staining patterns of the exocrine pancreas by indirect immunoflourescence appear to be specific markers of Crohn's disease (CrD), being present in approximately 30% of patients with ..
  83. pmc Progenitor cell domains in the developing and adult pancreas
    Janel L Kopp
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
    Cell Cycle 10:1921-7. 2011
    Unlike organs with defined stem cell compartments, such as the intestine, the pancreas has limited capacity to regenerate...
  84. ncbi An illustrated review of early pancreas development in the mouse
    Mette Christine Jørgensen
    Hagedorn Research Institute, Department of Developmental Biology, Niels Steensens Vej 6, DK 2820 Gentofte, Denmark
    Endocr Rev 28:685-705. 2007
    b>Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates during fetal development...
  85. doi An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials
    M Ligueros-Saylan
    Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
    Diabetes Obes Metab 12:495-509. 2010
    ..To assess the safety of vildagliptin versus all comparators (ACs) with regard to organs, systems or tissues of particular interest in type 2 diabetes (T2DM) and areas of potential concern with dipeptidyl peptidase-IV (DPP-4) inhibitors...
  86. doi Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells
    Olivia G Kelly
    ViaCyte, Inc formerly Novocell, Inc, San Diego, California, USA
    Nat Biotechnol 29:750-6. 2011
    ..These antibodies will aid investigations that use pancreatic cells generated from pluripotent stem cells to study diabetes and pancreas biology.
  87. doi Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells
    Luan Wen
    Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 510663 Guangzhou, China
    Dev Dyn 239:2198-207. 2010
    ..embryonic expression pattern, showing characteristic expression in the central nervous system as well as in the pancreas and part of the stomach/duodenum (SD) at tadpole stages of development...
  88. pmc Unperturbed islet α-cell function examined in mouse pancreas tissue slices
    Ya Chi Huang
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    J Physiol 589:395-408. 2011
    ..An acute pancreas slice preparation was developed to overcome the enzymatic and mechanical perturbations inherent in conventional ..
  89. doi Biochemical and molecular characterization of purified chicken pancreatic phospholipase A2
    Aida Karray
    Laboratoire de Biochimie et de Genie Enzymatique des Lipases, ENIS, Sfax, Tunisia
    FEBS J 276:4545-54. 2009
    ..To investigate the structure-activity relationships, a 3D model of group IB ChPLA(2) was built using the porcine pancreatic phospholipase A(2) structure as template...
  90. doi Cdc42-mediated tubulogenesis controls cell specification
    Gokul Kesavan
    Stem Cell and Pancreas Developmental Biology, Stem Cell Center, Lund University, BMC, SE 22184 Lund, Sweden
    Cell 139:791-801. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  91. ncbi Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas
    Omer Coskun
    Department of Medical Histology and Embryology, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey
    Pharmacol Res 51:117-23. 2005
    ..These findings suggest that QE treatment has protective effect in diabetes by decreasing oxidative stress and preservation of pancreatic beta-cell integrity...
  92. ncbi Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development
    Jessica Dessimoz
    Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Case Postale, CH 1066 Epalinges s Lausanne, Switzerland
    Curr Biol 15:1677-83. 2005
    ..and deregulation of adenomatous polyposis coli (APC) and beta-catenin are implicated in specific cancers of the pancreas, but the role of Wnt pathway in normal pancreas development and homeostasis is unknown...
  93. ncbi Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study
    Chun Mei Zhao
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Cell Tissue Res 331:575-87. 2008
    ..Tissue samples collected from the gastrointestinal tract and pancreas were examined by double-immunofluorescence staining, immunoelectron microscopy, and conventional electron ..
  94. pmc RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas
    C N Adra
    Harvard Institutes of Medicine, HIM955, Beth Israel Hospital, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 94:4279-84. 1997
    ..under low stringency, we have cloned a homologous cDNA preferentially expressed at high levels in brain and pancreas. The predicted protein, named RhoGDIgamma, is approximately 50% identical to GDI/D4 and RhoGDI...
  95. ncbi Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
    H Zulewski
    Division of Endocrinology and Diabetes, University Hospital of Geneva, Switzerland
    Diabetes 50:521-33. 2001
    ..Focal regions of nestin-positive cells are also identified in large, small, and centrolobular ducts of the rat pancreas. Nestin-positive cells in the islets and in pancreatic ducts are distinct from ductal epithelium because they do ..
  96. ncbi Delayed (18)F-fluoro-2-deoxy-D-glucose positron emission tomography scan for differentiation between malignant and benign lesions in the pancreas
    Y Nakamoto
    Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Cancer 89:2547-54. 2000
    ..The aim of this study was to investigate the usefulness of delayed scanning in differentiation between malignant and benign lesions in the pancreas.
  97. pmc B cells develop in the zebrafish pancreas
    Nadia Danilova
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:13711-6. 2002
    ..Also by day 4, rag1 transcripts are seen in the pancreas, an organ not previously associated with lymphopoiesis; by day 10, Igmu transcripts are detected here...
  98. pmc A better model of acute pancreatitis for evaluating therapy
    J Schmidt
    Departments of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114
    Ann Surg 215:44-56. 1992
  99. ncbi Pancreatic fat content and beta-cell function in men with and without type 2 diabetes
    Maarten E Tushuizen
    Department of Endocrinology Diabetes Center, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Diabetes Care 30:2916-21. 2007
    ..Experimental data indicate that fatty infiltration of pancreatic islets may also contribute to beta-cell dysfunction, but whether this occurs in humans in vivo is unknown...
  100. ncbi Nutrition, glucocorticoids and pancreas development
    B Breant
    INSERM Unit 690, Robert Debre Hospital, Paris, France
    Horm Res 65:98-104. 2006
    ..In terms of beta-cell ontogeny, expression of the glucocorticoid receptor in the pancreas coincides with that of the transcription factor Pdx-1 in beta cells...
  101. ncbi Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
    Ben Z Stanger
    Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, and Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, USA
    Nature 445:886-91. 2007
    ..Here, we report that the size of the mouse pancreas is constrained by an intrinsic programme established early in development, one that is essentially not subject to ..

Research Grants77

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..It is life saving when used on the surfaces of solid visceral organs, such as the liver spleen, pancreas and kidney, involved in trauma, cancer and transplantation in presence of coagulopathies or anticoagulation...
  2. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..modulates peripheral metabolism through effects on adipose tissue, the liver, skeletal muscle and the endocrine pancreas. Over-activity of eCB/CB1 signaling at any or all of these sites can result in increased food intake and/or ..
  3. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..for the mouse (application of rAAV vectors encoding the WT ferret CFTR cDNA) for in vivo gene delivery to the pancreas in CFTR-/- ferrets...
  4. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..with diabetes are at higher risk than the general population of developing cancer of the urinary tract, liver, pancreas, colon, endometrium and kidney...
  5. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..Finally, to test the validity of putative bone-pancreas endocrine loop in vivo, we will determine the effect of a hyperinsulinemic-euglycemic clamp on circulating ..
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..Blood sugar levels are regulated by the action of the hormone insulin that is released from the pancreas and that acts in many tissues throughout the body, causing glucose to go into cells and out of the bloodstream...
    ..We propose to study pathways involved both in the initiation and termination of inflammatory pain in the pancreas. Although ion channels of the transient receptor potential (TRP) family are known to promote inflammation and ..
    Jarmo Virtamo; Fiscal Year: 2010
    ..2005 include approximately 2,800 lung, 2,000 prostate, 700 colorectal, 500 bladder, 300-400 each for stomach, pancreas, and kidney cancers, 300 head and neck, and 1,100 for other sites combined...
  9. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Chronic pancreatitis is a serious and painful disorder of exocrine pancreas with no effective therapeutic measures...
  10. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..These peptides have pleotropic effects including stimulating growth of b cells of the pancreas and action on adipocytes. To date there is limited data about a direct role of GLP-1 in hepatocytes...
  11. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2012
    ..processes are connected by the enzyme, glycine N-methyltransferase, which is abundant in liver, exocrine pancreas and prostate as well as in kidney and intestinal mucosa in lower amounts...
  12. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..uncarboxylated osteocalcin (ucOC), improves insulin sensitivity in fat cells, increases insulin production by the pancreas, and reduces the risk of weight gain and development of diabetes...
  13. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..detection can be significantly improved, which will take us, a step closer to developing a closed-loop artificial pancreas. Study Design: We propose to develop a low-bias glucose+O2 sensing element (which is devoid of interference from ..
  14. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..diagnosed with cancers of colon, rectum, cervix, endometrium, bladder, stomach, head and neck, lung, esophagus, pancreas, osteosarcoma, ovary, and testis, for which first-line therapy can potentially include platinating agents...
  15. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ..pancreatic polypeptide (IAPP) in the islets of Langerhans is the characteristic feature of human type 2 diabetic pancreas but represents the final stage of a process started long before...
  16. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..that are located in nearly every human tissue, including the heart, vessel walls and beta cells of the pancreas. Melatonin is a hormone secreted by the pineal gland (under the control of the suprachiasmatic nucleus) and ..
  17. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..which leads to its nuclear exclusion, thereby altering gene expression including derepressing transcription of pancreas duodenum homeobox-1 (PDX-1)...
  18. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2013
    ..these hypotheses in mice with genetically altered expression of key elements in the proposed signaling pathways - pancreas specific PPAR? knockout, whole animal heterozygous FoxO1, and constitutively nuclear FoxO1 in [unreadable]-cells ..
  19. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..Area (11) Regenerative Medicine: 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, hematology, kidneys and urological system...
  20. Regulation of glucose metabolism by bone resorption and gamma-carboxylation
    Mathieu Ferron; Fiscal Year: 2012
    ..Here I will generate conditional knockout mice lacking ?-carboxylation in the whole pancreas or in specific endocrine cells and verify the impact on whole body glucose homeostasis...
  21. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
    ..and basic researchers with expertise in neoplastic processes of the skin, head and neck, lung, colorectum, pancreas, breast, ovary and cervix, as well as technical expertise in, and resources for, surface- enhanced laser ..
  22. Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic Fibrosis
    Aliye Uc; Fiscal Year: 2013
    ..Determine the effect of reactive oxygen species (ROS) and oxidative stress on insulin secretion in vivo by the CF pancreas;(2) Determine the effect of CF-related PUFA imbalance on insulin secretion in vivo by the CF pancreas;(3) ..
  23. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    ..Enteral exclusion of bile-pancreatic juice by the stone causes feedback hyperstimulation of the exocrine pancreas that induces pancreatic overproduction of acute inflammatory mediators...
  24. Neuronal mRNA PET Imaging
    Eric Wickstrom; Fiscal Year: 2010
    ..IRS1, MYCC, and KRAS mRNAs have enabled us to visualize gene expression in live mice bearing breast cancer, pancreas cancer, and prostate cancer xenografts. Mismatch probes and control cells yielded background signals...
  25. Building Mouse Models of Metabolic Syndrome
    Karen L Svenson; Fiscal Year: 2013
    ..Thorough histological evaluation of heart, liver, and pancreas will complete a comprehensive metabolic syndrome profile of each mutant strain, providing cardiovascular ..
    ..Medicine and specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, hematologic, and urologic system...
    Radhakrishna Rao; Fiscal Year: 2013
    ..The outcome of these studies is expected to provide knowledge to develop new therapies in the treatment of alcoholic liver disease and alcohol-induced tissue injury in pancreas and lung.
  28. Cx43 phosphorylation modulates Kras mediated pancreas cancer progression
    Paul D Lampe; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): With an annual incidence and mortality of ~38,000 people, pancreas cancer or pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in the United States...
  29. Neuroendocrine Response to Gastric Bypass in Nonhuman Primates
    Randy J Seeley; Fiscal Year: 2010
    ..The proposed studies will increase our understanding of the mechanisms by which the GI tract, pancreas and CNS regulate metabolic function...
  30. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    ..role in the progression and metastasis of a variety of tumors, including those of breast, prostate and pancreas;at the same time, little is known about its potential role in the biology of NSCLC...
  31. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..sequelae are known as neurogenic inflammation and appear to be important in many organs systems including the pancreas. Factors that stimulate primary sensory neurons include hydrogen ions, heat, leukotrienes, arachidonic acid ..
  32. CTGF promotes beta cell proliferation &revascularization in islet transplants
    Uma Gunasekaran; Fiscal Year: 2011
    ..In the pancreas, connective tissue growth factor (CTGF), a secreted protein in the CCN family, is expressed in embryonic beta ..
  33. Resolving the role of nicotine-mediated phosphorylation on pancreatic fibrosis
    Joao A Paulo; Fiscal Year: 2013
    ..National Commission on Digestive Diseases, seeking to investigate the role of smoking and PaSC in fibrosis of the pancreas. The work proposed herein is in line with my long-term goal to understand more clearly the mechanisms of ..
    HYUNG D RYOO; Fiscal Year: 2010
    ..impair elF2(_ dephosphorylation on cell survival in ER stress and on the function of tissues such as liver and pancreas that engage in heavy secretion...
  35. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..Loss of insulin producing cells in the pancreatic islets, the endocrine component of pancreas, referred as beta cell mass (BCM), leads to an inability to manage blood sugar levels...
  36. Role of Selectins in Burns and Inhalation Injury
    Daniel Traber; Fiscal Year: 2009
    ..will prevent the activation of blood PMNs, PARP and NF-kappaB and limit tissue damage seen in the lung, ileum, pancreas, skeletal muscle and liver after burn and inhalation injury...
  37. Hyperglycemia-induced DNA damage as a driver of genomic instability
    JOHN S TERMINI; Fiscal Year: 2013
    ..This condition significantly increases risk for cancers of the colon, liver, pancreas, kidney, breast, cervix, and endometrium;however, the mechanisms responsible remain unknown...
    Domenico Accili; Fiscal Year: 2013
    ..of mechanisms by which non-canonical sites of insulin action, such as central nervous system (CNS) and endocrine pancreas, play an early and decisive role in the progression from insulin resistance to diabetes;and (iii) the notion that ..
  39. Gq-coupled Receptors Inhibit PI 3-kinase/Akt Signaling Pathway
    Richard Z Lin; Fiscal Year: 2012
    ..3‐kinase (PI3K) p110alpha and p110beta in regulating pathological and physiological cell growth in the pancreas and skeletal muscle...
  40. FASEB SRC on
    Bradley K Yoder; Fiscal Year: 2013
    ..hallmarks of ciliopathies are the formation of cysts in the kidney as well as in other duct structures of the pancreas and liver. In addition, BBS and ALS patients are morbidly obese and have mental and sensory deficits...
  41. Therapeutic Potential of PARP inhibitor for Acute Pancreatitis
    Latha Paka; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Acute Pancreatitis (AP) is a potentially lethal inflammatory disease of the pancreas. Its pathogenesis remains obscure and is involved in a process of acute inflammation and necrosis in the pancreas, ..
  42. The Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland Develop
    BUFFY SUE ELLSWORTH; Fiscal Year: 2010
    ..transcription factor, FOXO1, is essential for the normal development and function of muscle, blood vessels, and pancreas. The pattern of FOXO1 localization in the pituitary gland during development suggests a role for inhibiting cell ..
  43. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..Somatostatin will be used when required to disable the endocrine pancreas, along with intraportal infusion of insulin and glucagon at the rates required by the experimental design...
  44. Systemic Factors that Maintain a Young Liver Phenotype
    Roy G Smith; Fiscal Year: 2012 important because the liver is pivotal for regulating metabolism and is modulated by input from the brain, pancreas, fat and muscle...
  45. A Microfluidic-platform Mini-Liver System for Human Liver Biology Studies
    HONGSEOK M NOH; Fiscal Year: 2010
    ..The hepatic portal vein carries blood from the intestines, pancreas, spleen and gallbladder and exposes the liver to nutrients and toxins derived from these sources...
  46. Chemoprevention of Pancreatic Cancer by Capsaicin
    Sanjay K Srivastava; Fiscal Year: 2013
    ..Interestingly, the viability of acinar cells derived from normal human pancreas or immortalized normal human pancreatic ductal epithelial (HPDE-6) cells were minimally affected by capsaicin...
    Hans Schreiber; Fiscal Year: 2013
    ..A large percentage of common human cancers (e.g., colon, breast, lung, prostate, ovary and pancreas) have defects in O-linked glycosylation thereby generating tumor-specific epitopes on surface glycoproteins of ..
  48. Pathological Evaluation of a Cystic Fibrosis Ferret Model
    John F Engelhardt; Fiscal Year: 2010 tackle this issue while also addressing biologic questions about early transcriptional changes within the CF pancreas and lung...
  49. Early Pathogenesis of Cystic Fibrosis Related Diabetes
    Andrew W Norris; Fiscal Year: 2013
    ..CF is a multi-organ disease affecting the lung, pancreas, liver, intestine, and gallbladder...
  50. Epidemiology of Putative Causal Variants in the Multiethnic Cohort
    Loic Le Marchand; Fiscal Year: 2012
    ..g., lung, pancreas, endometrial cancers, NHL) but for which we propose to pool our data with other funded groups;3) common traits ..
  51. Dietary Regulation of Pancreatic Digestive Enzymes
    John A Williams; Fiscal Year: 2013
    The overall aim of this work is to understand how the growth of the adult pancreas is regulated to provide an adequate supply of digestive enzymes. We hypothesize that growth can occur by two mechanisms...
  52. Pregnancy and EARly Lifestyle improvement Study (PEARLS)
    Kaumudi J Joshipura; Fiscal Year: 2013
    ..Obesity and hyperglycemia in pregnancy impact fetal growth through over-nutrition and may stress the feta pancreas. Such intrauterine programming events affect birth weight and raise the offspring's risk trajectory for ..
  53. Targets of a cytidine deaminase required for left-right axis in Xenopus
    Alin Vonica; Fiscal Year: 2010
    ..for correct orientation of asymmetric internal organs (left-right asymmetry), such as the heart, gut, liver, and pancreas, suggesting a novel molecular mechanism for an essential developmental process...
  54. NAPS2 Continuation Genome Wide Association Study of Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2011
    ..Pancreatitis Study 2 (NAPS2) began in 2002 as a prospective molecular epidemiology study conducted at 20 expert pancreas centers across the US...
  55. Obesity related pancreatic fat worsens local injury via unsaturated fatty acids
    VIJAY PREM SINGH; Fiscal Year: 2013
    ..PRELIMINARY DATA: To study this obesity-associated exacerbation of AP, we examined pancreas histology from autopsies of controls and patients with pancreatitis...
  56. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2012
    ..The major fraction of arsenic retained in tissues of these mice, including liver, pancreas, adipose and skeletal muscle tissues, was represented by methylated arsenicals, the products of the methylation ..
    Joseph J Cullen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adenocarcinoma of the pancreas is the fourth leading cause of cancer death in the United States and is increasing in incidence;the prognosis remains dismal...
  58. Development of Human, Autologous, Pluripotent Very Small Embryonic Like (VSELs) s
    DENIS OVEREND RODGERSON; Fiscal Year: 2013 animal models of myocardial infarct and may also be effective in repairing other tissues including retina and pancreas. Consequently, VSELs might be an ideal cell therapy to regenerate the body's immune system and repair other ..
    Alexander A Spector; Fiscal Year: 2012
    ..of its close family members, which are implicated in diseases associated with anion homeostasis within the lung, pancreas, kidney, colon and inner ear...
  60. Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response: A Phase I Trial
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2012
    ..This is based on preliminary data in mice with human NSCLC or pancreas cancer xenografts fed KD during radiotherapy demonstrate enhanced therapeutic responses and increases in ..
  61. Reciprocal Control of Ca2+ Channels by Anchored Protein Kinase A and Calcineurin
    William A Sather; Fiscal Year: 2010
    ..contraction of smooth muscle cells that are wrapped around blood vessels, and secretion of insulin from the pancreas. Calcium channels are therefore targets of drugs used to protect against nerve cell death following stroke, to ..
  62. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..the development of tools to measure mobile zinc stores that occur in other tissues such as the prostate and pancreas, where quantitation of mobile Zn2+ has the potential for early detection of diseases involving these organs...
  63. Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol
    Mokenge P Malafa; Fiscal Year: 2012
    ..cancer, and b) that 4-tocotrienol inhibits the effectors of oncogenic Ras signal transduction pathways in the pancreas and that this effect accounts for its antitumor activity...
  64. New Solutions to Improve Islet Recovery after Machine Preservation of Pancreas
    Michael Taylor; Fiscal Year: 2009
    ..To this end, a prototype pancreas transporter (PTR) has been designed and constructed in a previous study that demonstrated the feasibility of 24h ..
  65. HCO3- Conductive function of CFTR: Implications to Oral Health & Cystic Fibrosis
    MADIREDDI REDDY; Fiscal Year: 2010 applicant): Bicarbonate is a vital component of secretions from exocrine glands such as salivary glands, pancreas, duodenum, reproductive organs, sweat glands and the airways...
  66. Nanotechnology enabled desktop image-guided microbeam radiation therapy system
    OTTO Z contact ZHOU; Fiscal Year: 2010
    ..However, these benefits diminish for patients with radioresistant tumors, such as brain or pancreas cancers, and patients with late stage tumor...
  67. Program Project,Restoration of Endocrine Pancreas Funct*
    JOEL HABENER; Fiscal Year: 2004
    ..of using stem/progenitor cells and modified pancreatic islets as cellular therapies to restore endocrine pancreas function and to thereby cure diabetes mellitus...
  68. Novel Breath Test To Detect Early Stage Chronic Pancreatitis
    DAVID A contact WAGNER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Disorders of the pancreas affect more than one million persons in this country with nearly $3 billion in health care costs...
  69. Fibroblast Growth Factor Regulation in the Pancreas
    Sam Holmstrom; Fiscal Year: 2009
    The exocrine portion of the pancreas regulates digestion and is an important modulator of nutrient uptake. Abnormalities in exocrine pancreas function can lead to serious conditions such as pancreatitis and pancreatic cancer...
  70. Intraislet Communication in Surgically-Altered Pancreas
    FRANCIS BRUNICARDI; Fiscal Year: 2007
    ..the observations in mice to human islets and determine the role of SSTR5 and SSTR1 in the human endocrine pancreas in three specific aims: Specific Aim 1...
  71. A Tumor-Specific Nanoimmunocomplex Markedly Improves MR Imaging
    Esther Chang; Fiscal Year: 2006
    ..The American Cancer Society estimates that 32,000 Americans will be diagnosed with carcinoma of the pancreas in 2005, and 31,800 will die. Pancreatic cancer is the fourth leading cause of cancer death in the US...
  72. Recurrence of T1D in Pancreas Transplantation
    George Burke; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Since 1990 we have performed over 275 simultaneous pancreas and kidney (SPK) transplants in patients with type 1 diabetes (T1D) and end-stage renal disease. We are presently following 225 recipients...
  73. A Novel Method to Isolate Islet Cells
    JERRY KNOBELOCH; Fiscal Year: 2007
    ..this Phase I proposal are: 1) construction and bench testing of a novel device to dissociate tissue from donor pancreas using ultrasound for the recovery of pancreatic islet cells for transplantation, and 2) marked improvement in ..
  74. Statistical Functional Data Analysis Models of Glucose and Insulin Kinetics
    Inna Chervoneva; Fiscal Year: 2010
    ..The long-term goal is to develop a mechanical artificial pancreas that combines a glucose sensor, an insulin pump, and a controller to allow automated regulation of the insulin ..
    Linda Bradley; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the Investigator's abstract): Infiltration of autoreactive CD4 T lymphocytes into the pancreas represents a hallmark event in the development of insulin-dependent autoimmune diabetes...
    Ahmed Gaber; Fiscal Year: 2005
    ..Our team of clinicians and islet researchers has a long history of experience in the treatment of diabetes by pancreas and pancreas- kidney transplantation and an extensive experience in human islet isolation, preservation and ..
  77. Pioglitazone Therapy for Endocrine and Exocrine Disease in Alcoholic Pancreatitis
    MATTHEW DIMAGNO; Fiscal Year: 2009
    ..In collaboration with the Dr. M.A. Anderson and the clinical GI pancreas group, and Dr. W.H...