Summary: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.

Top Publications

  1. ncbi Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets
    Claus Lindbjerg Andersen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Cancer Res 64:5245-50. 2004
  2. pmc Diversity of the human intestinal microbial flora
    Paul B Eckburg
    Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Room S 169, 300 Pasteur Drive, Stanford CA 94305 5107, USA
    Science 308:1635-8. 2005
  3. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
  4. doi Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
    Maria T Abreu
    Division of Gastroenterology, University of Miami Miller School of Medicine, P O Box 016960 D 49, Miami, Florida 33101, USA
    Nat Rev Immunol 10:131-44. 2010
  5. doi Inflammation and colon cancer
    Janos Terzic
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Gastroenterology 138:2101-2114.e5. 2010
  6. pmc A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    Shaoguang Wu
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 15:1016-22. 2009
  7. pmc NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    Eran Elinav
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 145:745-57. 2011
  8. pmc The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, 405 30 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 108:4659-65. 2011
  9. doi Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism
    Mar Larrosa
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    J Nutr Biochem 21:717-25. 2010
  10. pmc Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    Emina H Huang
    Department of Surgery, University of Florida, Gainesville, Florida, USA
    Cancer Res 69:3382-9. 2009

Detail Information

Publications400 found, 100 shown here

  1. ncbi Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets
    Claus Lindbjerg Andersen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Cancer Res 64:5245-50. 2004
    ..We used the model-based strategy to identify genes suited to normalize quantitative RT-PCR data from colon cancer and bladder cancer...
  2. pmc Diversity of the human intestinal microbial flora
    Paul B Eckburg
    Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Room S 169, 300 Pasteur Drive, Stanford CA 94305 5107, USA
    Science 308:1635-8. 2005
    ..We discovered significant intersubject variability and differences between stool and mucosa community composition. Characterization of this immensely diverse ecosystem is the first step in elucidating its role in health and disease...
  3. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
    ..four to six crypt stem cells reside at the +4 position immediately above the Paneth cells in the small intestine; colon stem cells remain undefined...
  4. doi Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
    Maria T Abreu
    Division of Gastroenterology, University of Miami Miller School of Medicine, P O Box 016960 D 49, Miami, Florida 33101, USA
    Nat Rev Immunol 10:131-44. 2010
    ..result in chronic inflammatory and over-exuberant repair responses, and it is associated with the development of colon cancer...
  5. doi Inflammation and colon cancer
    Janos Terzic
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Gastroenterology 138:2101-2114.e5. 2010
    ..Inflammatory bowel disease is an important risk factor for the development of colon cancer. Inflammation is also likely to be involved with other forms of sporadic as well as heritable colon cancer...
  6. pmc A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    Shaoguang Wu
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 15:1016-22. 2009
    The intestinal flora may promote colon tumor formation. Here we explore immunologic mechanisms of colonic carcinogenesis by a human colonic bacterium, enterotoxigenic Bacteroides fragilis (ETBF). ETBF that secretes B...
  7. pmc NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    Eran Elinav
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 145:745-57. 2011
    ..Altogether, perturbations in this inflammasome pathway, including NLRP6, ASC, caspase-1, and IL-18, may constitute a predisposing or initiating event in some cases of human IBD...
  8. pmc The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, 405 30 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 108:4659-65. 2011
    The normal intestinal microbiota inhabits the colon mucus without triggering an inflammatory response. The reason for this and how the intestinal mucus of the colon is organized have begun to be unraveled...
  9. doi Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism
    Mar Larrosa
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    J Nutr Biochem 21:717-25. 2010 evaluate the effects of pomegranate intake and its main microbiota-derived metabolite urolithin-A (UROA) on colon inflammation and to assess whether UROA is the main anti-inflammatory compound...
  10. pmc Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    Emina H Huang
    Department of Surgery, University of Florida, Gainesville, Florida, USA
    Cancer Res 69:3382-9. 2009
    ..been hindered by a paucity of specific markers for identification and isolation of SC from normal and malignant colon. Accordingly, aldehyde dehydrogenase 1 (ALDH1) was investigated as a possible marker for identifying colonic SC ..
  11. pmc Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces
    Erwin G Zoetendal
    Wageningen Centre for Food Sciences, Laboratory of Microbiology, Hesselink van Suchtelenweg 4, 6703 CT Wageningen, The Netherlands
    Appl Environ Microbiol 68:3401-7. 2002
    ..bacteria present in feces, knowledge about the mucosa-associated bacterial communities in different parts of the colon is limited...
  12. doi Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    Toshiro Sato
    Hubrecht Institute, KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands
    Gastroenterology 141:1762-72. 2011
    ..We have adapted the culture conditions to grow similar epithelial organoids from mouse colon and human small intestine and colon.
  13. ncbi Review article: the role of butyrate on colonic function
    H M Hamer
    TI Food and Nutrition, Wageningen, The Netherlands
    Aliment Pharmacol Ther 27:104-19. 2008
    ..Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis...
  14. pmc Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon
    Xiaolei Ze
    Microbial Ecology Group, Rowett Institute of Nutrition and Health, Greenburn Road, Bucksburn, Aberdeen, UK
    ISME J 6:1535-43. 2012
    The release of energy from particulate substrates such as dietary fiber and resistant starch (RS) in the human colon may depend on the presence of specialist primary degraders (or 'keystone species') within the microbial community...
  15. pmc Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors
    C C Bain
    Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK
    Mucosal Immunol 6:498-510. 2013
    ..We show here that most resident mφ in resting mouse colon express very high levels of CX3CR1, are avidly phagocytic and MHCII(hi), but are resistant to Toll-like receptor (..
  16. pmc Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
    Aymeric Rivollier
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 209:139-55. 2012
    Dendritic cells (DCs) and macrophages (MPs) are important for immunological homeostasis in the colon. We found that F4/80(hi)CX3CR1(hi) (CD11b(+)CD103(-)) cells account for 80% of mouse colonic lamina propria MHC-II(hi) cells...
  17. doi A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    Ben P Willing
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Gastroenterology 139:1844-1854.e1. 2010
    ..Interindividual variation and an inability to detect less abundant bacteria have made it difficult to correlate specific bacteria with disease...
  18. ncbi Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer
    Andrew J Wilson
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York 10467, USA
    J Biol Chem 281:13548-58. 2006
    Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and apoptosis of colon cancer cell lines in vitro and have demonstrated anti-cancer efficacy in clinical trials...
  19. ncbi Interactions and competition within the microbial community of the human colon: links between diet and health
    Harry J Flint
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB219SB, UK
    Environ Microbiol 9:1101-11. 2007
    ..Surveys of 16S rRNA sequence diversity in the human colon have emphasized the low proportion of sequences that match cultured bacterial species...
  20. pmc Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
    Stefanie Kirchberger
    Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, University of Oxford, Headington, Oxford OX3 9DU, UK
    J Exp Med 210:917-31. 2013
    Patients with inflammatory bowel disease (IBD) have an increased risk of colon cancer. However, the immune cells and cytokines that mediate the transition from intestinal inflammation to cancer are poorly understood...
  21. doi Uremic solutes from colon microbes
    Timothy W Meyer
    Department of Medicine, VA Palo Alto HCS and Stanford University, Palo Alto, California 94303, USA
    Kidney Int 81:949-54. 2012
    ..A large number of these waste solutes are produced by colon microbes...
  22. pmc Selective upregulation of microRNA expression in peripheral blood leukocytes in IL-10-/- mice precedes expression in the colon
    Jeremy S Schaefer
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Center at Houston, TX 77030, USA
    J Immunol 187:5834-41. 2011
    ..mice, changes in miRNAs in PBL of dextran sulfate sodium-treated mice were minimal but selectively elevated in the colon after pathology was severe...
  23. pmc Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer
    Eveline J Steine
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts, USA
    J Clin Invest 121:1748-52. 2011
    ..some of these issues by demonstrating that transgenic expression of DNA methyltransferase 3b (Dnmt3b) in the mouse colon initiates de novo DNA methylation of genes that are similar to genes that become methylated in human colon cancer...
  24. ncbi Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 118:229-41. 2004
    ..These findings reveal a novel function of TLRs-control of intestinal epithelial homeostasis and protection from injury-and provide a new perspective on the evolution of host-microbial interactions...
  25. ncbi Citrobacter rodentium of mice and man
    Rosanna Mundy
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London SW7 2AZ, UK
    Cell Microbiol 7:1697-706. 2005
    ..Here we review the literature of C. rodentium from its emergence in the mid-1960s to the most contemporary reports of colonization, pathogenesis, transmission and immunity...
  26. ncbi Clonogenic growth of epithelial cells from normal colonic mucosa from both mice and humans
    R H Whitehead
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Melbourne, Australia
    Gastroenterology 117:858-65. 1999
    ..The factors controlling the proliferation and differentiation of the colonic mucosa are unknown and have proved difficult to identify mainly because of a lack of in vitro methods for studying the proliferative cells of the mucosa...
  27. ncbi Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    Giovanni Barbara
    Departmentof Internal Medicine and Gastroenterology, and CRBA, University of Bologna, Italy
    Gastroenterology 126:693-702. 2004
    ..We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients...
  28. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..hTcf-4 transactivates transcription only when associated with beta-catenin. Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active, as ..
  29. ncbi Mucins and mucin binding proteins in colorectal cancer
    James C Byrd
    The Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 436 Houston, TX 77030, USA
    Cancer Metastasis Rev 23:77-99. 2004
    ..MUC1 mucin, as detected immunologically, is increased in expression in colon cancers, which correlates with a worse prognosis...
  30. pmc Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 4:e6073. 2009
    ..In this study we systematically analyzed clinical parameters, histological changes, intestinal barrier properties and cytokine profile during the colitic and recovery phase...
  31. ncbi The microbiology of butyrate formation in the human colon
    Susan E Pryde
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    FEMS Microbiol Lett 217:133-9. 2002
    ..While certain dietary substrates such as resistant starch appear to be butyrogenic in the colon, it is not known to what extent these stimulate butyrate production directly, e.g...
  32. pmc Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans
    Junhai Ou
    Department of Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 98:111-20. 2013
    Epidemiologic studies have suggested that most cases of sporadic colon cancer can be attributed to diet...
  33. pmc Mitochondrial DNA mutations in human colonic crypt stem cells
    Robert W Taylor
    Department of Neurology, The Medical School, University of Newcastle upon Tyne, United Kingdom
    J Clin Invest 112:1351-60. 2003
    ..These studies have important consequences not only for understanding of the finding of mtDNA mutations in aging tissues and tumors, but also for determining the frequency of mtDNA mutations within a cell...
  34. doi Intestinal stem cell replacement follows a pattern of neutral drift
    Carlos Lopez-Garcia
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Science 330:822-5. 2010
    ..Combined with long-term clonal fate data, we show that the rate of stem cell replacement is comparable to the cell division rate, implying that neutral drift and symmetrical cell divisions are central to stem cell homeostasis...
  35. pmc Importance and regulation of the colonic mucus barrier in a mouse model of colitis
    J Petersson
    Department of Medical Cell Biology, Division of Integrative Physiology, Biomedical Center, Uppsala Univ, P O Box 571, SE 751 23 Uppsala, Sweden
    Am J Physiol Gastrointest Liver Physiol 300:G327-33. 2011
    ..Furthermore, regulation of mucus secretion by luminal bacterial products was studied. The colon of anesthetized Muc2(-/-), Muc1(-/-), wild-type (wt), and germ-free mice was exteriorized, the mucosal surface was ..
  36. pmc Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
    Bo Hu
    Department of Immunobiology, Section of Comparative Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:21635-40. 2010
    ..We suggest a model in which the NLRC4 inflammasome is central to colonic inflammation-induced tumor formation through regulation of epithelial cell response to injury...
  37. pmc The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis
    Md Hasan Zaki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 20:649-60. 2011
    ..We show that Nlrp12-deficient mice are highly susceptible to colon inflammation and tumorigenesis, which is associated with increased production of inflammatory cytokines, ..
  38. pmc Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma
    Jacek R Wisniewski
    Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Syst Biol 8:611. 2012
    ..Our proteomic data set furthermore allows mapping quantitative changes of functional protein classes, enabling novel insights into the biology of colon cancer.
  39. pmc cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue
    Lenora W M Loo
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
    PLoS ONE 7:e30477. 2012
    ..microsatellite stable and CpG island methylator phenotype-negative colorectal tumors and paired adjacent normal colon tissues were used for genome-wide SNP and gene expression profiling...
  40. doi Expression of the antiapoptotic protein survivin in colon cancer
    Jonathan M Hernandez
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA
    Clin Colorectal Cancer 10:188-93. 2011
    ..We sought to evaluate survivin expression in colonic neoplasia and identify relationships with additional regulators of apoptosis...
  41. doi Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue
    Aaron J Quyn
    Cell and Developmental Biology, University of Dundee, Dundee, DD1 5EH, UK
    Cell Stem Cell 6:175-81. 2010
    ..perpendicular to the apical surface specifically in the stem cell compartments of mouse and human intestine and colon. This orientation correlates with the asymmetric retention of label-retaining DNA...
  42. pmc Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
    Matthew D Johnston
    Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24 29 St Giles, Oxford OX1 3LB, United Kingdom
    Proc Natl Acad Sci U S A 104:4008-13. 2007
    ..The second model can be used to explain the long lag phases in tumor growth, during which new, higher equilibria are reached, before unlimited growth in cell numbers ensues...
  43. pmc Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    S J Ott
    Department of General Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Gut 53:685-93. 2004
    ..As most of the colonic bacteria cannot be identified by culture techniques, genomic technology can be used for analysis of the composition of the microflora...
  44. pmc n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon
    Laurie A Davidson
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843 2253, USA
    Carcinogenesis 30:2077-84. 2009
    ..were fed diets containing corn oil or fish oil with pectin or cellulose and injected with azoxymethane (AOM, a colon-specific carcinogen) or saline (control)...
  45. pmc NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    J Wehkamp
    Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
    Gut 53:1658-64. 2004
    ..Paneth cells also express NOD2. To address the hypothesis that the function of NOD2 may affect expression of Paneth cell defensins, we compared their expression levels with respect to NOD2 mutations in Crohn's disease...
  46. ncbi The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
    C Caballero-Franco
    Institute of Parasitology, McGill University, Saint Anne de Bellevue, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G315-22. 2007
    ..These findings contribute to a better understanding of the complex and beneficial interaction between colonic epithelial cells and intestinal bacteria...
  47. pmc Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 121:1657-66. 2011
    ..The colitis manifested in these mice was also characterized by TNF-producing myeloid infiltrates in colon mucosa in the absence of lymphocytes, supporting an essential role for myeloid cells in colitis initiation...
  48. doi The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire
    Michael B Zimmermann
    Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 92:1406-15. 2010
    ..Thus, increasing colonic iron could select gut microbiota for humans that are unfavorable to the host...
  49. pmc Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 USA
    Immunity 29:947-57. 2008
    ..In addition, IL-22 expression was differentially regulated between NK cell subsets. Thus, both the innate and adaptive immune responses have developed protective mechanisms to counteract the damaging effects of inflammation on tissues...
  50. doi Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell
    Shiro Yui
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Nat Med 18:618-23. 2012
    ..To test the transplantability of these cells, we reintroduced cultured GFP(+) colon organoids into superficially damaged mouse colon...
  51. pmc The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
    Jonathan P Katz
    Department of Genetics, University of Pennsylvania School of Medicine, 560 Clinical Research Building, 415 Curie Blvd, Philadelphia 19104 6145, USA
    Development 129:2619-28. 2002, we provide the first in vivo evidence that Klf4 is a goblet cell-specific differentiation factor in the colon. Klf4(-/-) mice exhibit normal cell proliferation and cell death rates in the colon on postnatal day 1...
  52. ncbi Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
    Shideng Bao
    The Key Laboratory for Cell Biology and Tumor Cell Engineering, The Ministry of Education of China, The School of Life Sciences, Xiamen University, Fujian 361005, China
    Cancer Cell 5:329-39. 2004
    ..Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors...
  53. ncbi Diagnostics of inflammatory bowel disease
    Susanna Nikolaus
    Department of General Internal Medicine, Christian Albrechts University, Kiel, Germany
    Gastroenterology 133:1670-89. 2007
    ..It can be expected that future diagnostic algorithms will include molecular parameters to detect early disease or guide therapies by predicting the individual course of disease...
  54. pmc Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Biol Cell 14:1790-800. 2003
    ..Using a novel EMT model of colon carcinoma spheroids, we demonstrate that their transforming-growth factor-beta1 (TGF-beta)-induced EMT is ..
  55. pmc Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    Gut 63:281-91. 2014
    The inner mucus layer in mouse colon normally separates bacteria from the epithelium...
  56. doi Low counts of Faecalibacterium prausnitzii in colitis microbiota
    H Sokol
    UEPSD, INRA, Jouy en Josas, France
    Inflamm Bowel Dis 15:1183-9. 2009
    ..The aim was to compare the fecal microbiota composition of patients with colitis to that of healthy subjects (HS)...
  57. pmc Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 5:e12238. 2010
    ..amount of commensal bacteria is a challenge that became easier to understand when we recently could describe that colon has an inner attached mucus layer devoid of bacteria (Johansson et al. (2008) Proc. Natl. Acad. Sci...
  58. pmc Comparison of microarray platforms for measuring differential microRNA expression in paired normal/cancer colon tissues
    Maurizio Callari
    Functional Genomics Core Facility, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    PLoS ONE 7:e45105. 2012
    ..miRNA analysis methods have only recently been systematically compared but only in few cases using clinical samples...
  59. ncbi Colorectal cancer in mice genetically deficient in the mucin Muc2
    Anna Velcich
    Department of Oncology, Albert Einstein Cancer Center Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA
    Science 295:1726-9. 2002
    ..Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer...
  60. pmc Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
    Oksana Voloshanenko
    1 German Cancer Research Center DKFZ, Div Signalling and Functional Genomics, and Heidelberg University, Dept Cell and Molecular Biology, Faculty of Medicine Mannheim, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany 2
    Nat Commun 4:2610. 2013
    ..has an important role during the onset and progression of colorectal cancer, with over 90% of cases of sporadic colon cancer featuring mutations in APC or β-catenin...
  61. pmc Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon
    Mara Jana Broadhurst
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 8:e1003000. 2012
    ..These results also define ICD in monkeys as a tractable preclinical model for ulcerative colitis in which these effects can be further investigated...
  62. doi Isolation and in vitro expansion of human colonic stem cells
    Peter Jung
    Oncology Program, Institute for Research in Biomedicine, Barcelona, Spain
    Nat Med 17:1225-7. 2011
    ..surface abundance of ephrin type-B receptor 2 (EPHB2) allows the purification of different cell types from human colon mucosa biopsies...
  63. pmc Changes in interstitial cells of cajal with age in the human stomach and colon
    P J Gomez-Pinilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 23:36-44. 2011
    ..The aim of this study was to determine the effect of aging on ICC number and volume in the human stomach and colon.
  64. pmc Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells
    Lijuan Wang
    Department of Oncology, The First Affiliated Hospital, College of Medicine, Xi an Jiaotong University, Xi an, P R China
    PLoS ONE 8:e65539. 2013
    ..This study investigated YAP and TAZ expression in both CRC patients and colon cancer cell lines, and assessed their prognostic value.
  65. doi A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
    Gary R Mirams
    Computational Biology, Department of Computer Science, University of Oxford, Parks Road, Oxford OX1 3QD, UK
    J Theor Biol 312:143-56. 2012
  66. ncbi Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters
    Francois Bertucci
    Département d Oncologie Moléculaire, Institut Paoli Calmettes and U119 Inserm, IFR57, Marseille, France
    Oncogene 23:1377-91. 2004
    ..We profiled 50 cancerous and noncancerous colon tissues using DNA microarrrays consisting of approximately 8000 spotted human cDNA...
  67. ncbi A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms
    N van Belzen
    Department of Pathology, Erasmus University Rotterdam, The Netherlands
    Lab Invest 77:85-92. 1997
    To identify new molecular markers for differentiation of normal and neoplastic colon epithelium, we have studied changes in gene expression during the in vitro differentiation of the HT29-D4 colon carcinoma cell line...
  68. pmc Fusobacterium nucleatum infection of colonic cells stimulates MUC2 mucin and tumor necrosis factor alpha
    Poonam Dharmani
    Gastrointestinal Research Group, Health Sciences Centre, University of Calgary, 3330 Hospital Drive, NW, Calgary, Alberta T2N 4N1, Canada
    Infect Immun 79:2597-607. 2011
    ..nucleatum may represent a challenging pathogen in the etiology of gut inflammatory diseases and highlight the importance of different pathotypes of candidate bacterial species in disease pathogenesis...
  69. ncbi Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    Atsuhiro Ogawa
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Clin Immunol 110:55-62. 2004
    ..In the mice treated with the anti-IL-17 mAb, the body weight was significantly lower, and anal prolapse and colon shortening were apparent...
  70. pmc Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tract
    Catherine Robbe
    Unité Mixte de Recherche CNRS USTL 8576, Glycobiologie Structurale et Fonctionnelle, IFR 118, Université des Sciences et Technologies de Lille 1, 59655 Villeneuve d Ascq cedex, France
    Biochem J 384:307-16. 2004
    Purified human mucins from different parts of the intestinal tract (ileum, cecum, transverse and sigmoid colon and rectum) were isolated from two individuals with blood group ALe(b) (A-Lewis(b))...
  71. doi Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate
    Mikihito Kajiya
    Department of Immunology, The Forsyth Institute, Boston, MA 02115, USA
    Biochem Biophys Res Commun 386:11-5. 2009
    ..pathogenic outcomes including, loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-alpha and IL-1beta in colon lesion, were significantly suppressed by the ..
  72. ncbi Bacteria, colonic fermentation, and gastrointestinal health
    George T Macfarlane
    University of Dundee, Ninewells Hospital Medical School, Microbiology and Gut Biology Group, Dundee DD1 9SY, United Kingdom
    J AOAC Int 95:50-60. 2012
    ..However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel...
  73. doi Comparison of probe-based confocal laser endomicroscopy with virtual chromoendoscopy for classification of colon polyps
    Anna M Buchner
    Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA
    Gastroenterology 138:834-42. 2010
    ..A secondary aim was to compare sensitivity and specificity of pCLE to virtual chromoendoscopy using a modified gold standard that assumed that all polyps >/=10 mm had malignant potential and were considered neoplastic or high risk...
  74. doi Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract
    Gary R Martin
    Inflammation Research Network, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dig Liver Dis 42:103-9. 2010
    ..Little is known about H2S synthesis in the gastrointestinal tract. The aim of this study was to characterize H2S synthesis throughout the gastrointestinal tract...
  75. ncbi Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon
    Markus Waldecker
    Food Chemistry and Environmental Toxicology, University of Kaiserslautern, D 67663 Kaiserslautern, Germany
    J Nutr Biochem 19:587-93. 2008
    ..fatty acids (SCFAs) possibly playing a major role as chemopreventive products of microbial fermentation in the colon. In this study, we investigated the effects of butyrate, other SCFAs, and of a number of phenolic SCFA and trans-..
  76. pmc Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
    B von Lampe
    Medizinische Klinik I Gastroenterologie und Infektiologie, Klinikum Benjamin Franklin, FU Berlin, Hindenburgdamm 30, 12200 Berlin, FRG
    Gut 47:63-73. 2000
    ..The current study was therefore designed to determine gene expression patterns of MMPs and their tissue inhibitors (TIMPs) in single endoscopic biopsies of patients with inflammatory bowel disease (IBD)...
  77. doi Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators
    T Piche
    INSERM U913, Nantes, France
    Gut 58:196-201. 2009
    ..We aimed to investigate (1) paracellular permeability in colonic biopsies of patients with IBS; and (2) the ability of soluble factors from colonic biopsies to reproduce these alterations in vitro...
  78. pmc Tissue-specific alternative splicing of TCF7L2
    Ludmila Prokunina-Olsson
    Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 18:3795-804. 2009
    ..multiple TCF7L2 splicing forms in up to 380 samples from eight types of human tissue (pancreas, pancreatic islets, colon, liver, monocytes, skeletal muscle, subcutaneous adipose tissue and lymphoblastoid cell lines) and observed a ..
  79. ncbi Activation of the mucosal immune system in irritable bowel syndrome
    Vinton S Chadwick
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Gastroenterology 122:1778-83. 2002
    ..A role for the mucosal immune system in the pathogenesis of irritable bowel syndrome is suggested by its association with intestinal infections...
  80. pmc miRNA expression in colon polyps provides evidence for a multihit model of colon cancer
    Ann L Oberg
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e20465. 2011
    Changes in miRNA expression are a common feature in colon cancer. Those changes occurring in the transition from normal to adenoma and from adenoma to carcinoma, however, have not been well defined...
  81. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
    ..barrier function and induced epithelial loss, crypt damage, and aggregation of neutrophils and lymphocytes in the colon. Conversely, administration of an EP4-selective agonist (AE1-734) to wild-type mice ameliorated severe colitis ..
  82. pmc MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
    Rosalba Salcedo
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA
    J Exp Med 207:1625-36. 2010
    ..This study revealed a previously unknown level of complexity surrounding MyD88 activities downstream of different receptors that impact tissue homeostasis and carcinogenesis...
  83. pmc Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor
    O Galamb
    Department of Medicine, Semmelweis University, Budapest, Hungary
    Br J Cancer 102:765-73. 2010
    ..We analysed the gene expression modulatory effect of N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS398) on HT29 cells to be correlated with expression data gained from biopsy samples...
  84. ncbi Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice
    K L Madsen
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Gastroenterology 116:1107-14. 1999
    ..The aim of this study was to determine the role of colonic aerobic luminal bacteria and Lactobacillus species in the development of colitis in interleukin (IL)-10 gene-deficient mice...
  85. ncbi Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels
    Eleonora Distrutti
    University of Perugia, Clinica di Gastroenterologia, Policlinico Monteluce, Via Enrico Dal Pozzo, 06122 Perugia, Italy
    J Pharmacol Exp Ther 316:325-35. 2006
    ..We found that CBS and CSE are expressed in the colon and spinal cord...
  86. ncbi Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1264-73. 2001
    ..b>Colon shortening following DSS-induced colitis was partially prevented in the treatment groups...
  87. ncbi Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer
    T Zhang
    Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 61:8664-7. 2001
  88. pmc Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon
    Seong Gyu Jeon
    Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS Pathog 8:e1002714. 2012
    ..These findings demonstrate that B. breve prevents intestinal inflammation through the induction of intestinal IL-10-producing Tr1 cells...
  89. doi Colon cancer stem cells: promise of targeted therapy
    Matilde Todaro
    Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, Palermo, Italy
    Gastroenterology 138:2151-62. 2010
    ..The traditional model of colon carcinogenesis includes several steps that occur via mutational activation of oncogenes and inactivation of tumor ..
  90. pmc DNA demethylation in normal colon tissue predicts predisposition to multiple cancers
    H Kamiyama
    Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Oncogene 31:5029-37. 2012
    Some colon cancer (CC) patients present synchronous cancers at diagnosis and others develop metachronous neoplasms, but the risk factors are unclear for non-hereditary CC...
  91. doi Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium-induced colitis in rats
    Ker Y Cheah
    Wine Science and Business Group School of Agriculture, Food and Wine, Waite Campus, The University of Adelaide, PMB 1, Glen Osmond, SA 5064, Australia
    Dig Dis Sci 58:970-7. 2013
    ..GSE has been demonstrated to exert encouraging anti-inflammatory and anti-ulcer properties in experimental settings, although its effects on inflammation of the colon remain undefined.
  92. pmc Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells
    Ya C Wu
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    PLoS ONE 7:e37572. 2012
    ..In the present study, the effect of H(2)S on the proliferation of normal and cancerous colon epithelial cells was investigated...
  93. doi Resveratrol oligomers isolated from Carex species inhibit growth of human colon tumorigenic cells mediated by cell cycle arrest
    Antonio Gonzalez-Sarrias
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States
    J Agric Food Chem 59:8632-8. 2011
    ..and Carex gynandra ), along with resveratrol, were evaluated for antiproliferative effects against human colon cancer (HCT-116, HT-29, Caco-2) and normal human colon (CCD-18Co) cells...
  94. pmc Intraperitoneal but not intravenous cryopreserved mesenchymal stromal cells home to the inflamed colon and ameliorate experimental colitis
    Morgana T L Castelo-Branco
    Laboratorio de Imunologia Celular, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 7:e33360. 2012
    ..We compared the homing and therapeutic action of cryopreserved subcutaneous adipose tissue (AT-MSCs) and bone marrow-derived mesenchymal stromal cells (BM-MSCs) in rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis...
  95. doi Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, 2 1 Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    J Gastroenterol 46:1187-96. 2011
    ..Therefore, we investigated the vasodilatory effect of TU-100 in a CD rat model...
  96. pmc Transplanted progenitors generate functional enteric neurons in the postnatal colon
    Ryo Hotta
    Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia
    J Clin Invest 123:1182-91. 2013
    ..We transplanted neurospheres generated from fetal and postnatal intestinal neural crest-derived cells into the colon of postnatal mice...
  97. pmc Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis
    Robert W Li
    USDA ARS ANRI, Bovine Functional Genomics Laboratory, Beltsville, Maryland, USA
    Infect Immun 80:2150-7. 2012
    ..In this study, we characterized the microbiota in the porcine proximal colon in response to Trichuris suis (whipworm) infection using 16S rRNA gene-based and whole-genome shotgun (WGS) ..
  98. doi Induction and activation of adaptive immune populations during acute and chronic phases of a murine model of experimental colitis
    Lindsay J Hall
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Dig Dis Sci 56:79-89. 2011
    ..Despite its continuing importance as a model system for examining IBD pathogenesis, the mucosal and systemic immune responses have not been comprehensively documented...
  99. pmc Detection of Campylobacter concisus and other Campylobacter species in colonic biopsies from adults with ulcerative colitis
    Indrani Mukhopadhya
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    PLoS ONE 6:e21490. 2011
    ..This study investigated the prevalence of Campylobacter species in colonic biopsy samples from adults with UC and healthy controls...
  100. ncbi Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression
    Robert Irons
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20852, USA
    J Nutr 136:1311-7. 2006
    ..Selenium homeostasis was characterized in liver and colon of wild-type and transgenic mice fed selenium-deficient diets supplemented with 0, 0.1, or 2...
  101. pmc Standard colonic lavage alters the natural state of mucosal-associated microbiota in the human colon
    Laura Harrell
    Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 7:e32545. 2012
    ..We examined if colonic lavage changes the natural state of enteric mucosal-adherent microbes in healthy human subjects...

Research Grants81

  1. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..However, curcumin has been effective in tumors, such as colon and HNC, where direct access to the drug is possible...
  2. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..resistance, tumor angiogenesis, and progression of many cancer types including ovarian, breast, prostate, thyroid, colon, brain and hematological malignancies...
  3. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013 recent years revealed that high vitamin D levels protect human body from many cancers, such as cancer of the colon, breast and prostate...
  4. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..11/565,779) for NOS antagonists and free radical scavengers, and mouse models where the bladder or descending colon is withdrawn through a small incision and selectively irradiated...
  5. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..6 million people dying from cancer in 2007. More people in the US die of lung cancer than breast, colon, kidney, and prostate cancers combined...
  6. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..Mutations in the colon due to E. faecalis colonization will be quantified using a hybrid IL-10-/-/Big Blue. Mutant model...
  7. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..In the in vitro portion of these experiments, gastric, colon, small intestine, and bladder epithelial cell lines from the H-2Kb- tsA58 mouse will be gradually adapted to ..
  8. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..e., the stomach, ileum and colon, respectively)...
  9. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..This hypothesis is based on our recent findings in colon and head and neck squamous carcinoma cell models that translational regulatory mechanisms inhibit tumor growth...
  10. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010 therapeutic strategies to prevent and treat osteoporosis with bone anabolic 1,25(OH)2D3 analogs, but could also shed light on the novel anticancer effects of vitamin D at sites such as the colon, skin, breast and
  11. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..and economic impact, like the inflammatory bowel disease (affecting about 1 person in every 500 in USA), the colon carcinoma (the second most frequent malignancy in developed countries) and numerous infectious diseases...
  12. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..animal studies suggest that amyloid light chains cause oxidative stress leading to tissue damage or dysfunction in colon and cardiac tissues...
  13. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..are at higher risk than the general population of developing cancer of the urinary tract, liver, pancreas, colon, endometrium and kidney...
  14. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    The aim of this submission is to develop a quantitative microRNA assay for screening right and left colon cancer in stool of patients, particularly at the early adenoma stage (e.g...
  15. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..secretion are hypertension, diabetes, obesity, osteoporosis, polycystic ovary syndrome and neoplasms of the colon, breast, ovary, and uterus...
  16. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ..epigenetic changes are region- and cell-specific, and "hardwired" to nociceptive DRGs innervating the GI tract (colon) vs. somatosensory (sciatic nerve) distribution...
  17. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..rats predisposed to heightened levels of anxiety due to unpredictable early life stress exhibit a hypersensitive colon in adulthood...
  18. Developing Physics-Based Virtual Simulation Technology for Natural Orifice Transl
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..natural successor of laparoscopic surgery, where internal organs are accessed by perforating the viscera (stomach, colon or vagina) using a flexible endoscope inserted through natural orifices such as the mouth, anus or vagina;without ..
  19. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ..the prognosis for this disease is more ominous than for many common types of cancer such as breast, prostate, and colon. The longterm goals of this laboratory are to define mechanism(s) for liver cell death in ALD that will provide ..
  20. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..Each year more than 5.8 million patients are diagnosed with cancers of colon, rectum, cervix, endometrium, bladder, stomach, head and neck, lung, esophagus, pancreas, osteosarcoma, ovary, and ..
    Walter C Willett; Fiscal Year: 2010
    ..dietary data, frozen plasma and DNA, and tumor tissue to address hypotheses regarding cancers of the prostate, colon and rectum, breast, and brain (glioma)...
  22. Novel CTD inhibitors with synthetic lethality to oncogenic Ras for cancer therapy
    Bingliang Fang; Fiscal Year: 2013
    ..analogues on NCI-60 cell lines showed that oncrasins are active against several cell lines derived from lung, colon, breast, ovary, and kidney cancers and oncrasin-60 lies outside the category of adequately studied classes of ..
    Vivian Bellofatto; Fiscal Year: 2010
    ..In the Western hemisphere, trypanosome infection causes fatal enlargement of the colon, as well as serious cardiomyopathy known as Chagas'disease...
    Moosa Mohammadi; Fiscal Year: 2013
    ..provide blueprints for drug discovery for major human diseases including diabetes, obesity, hypercholesterolemia, colon cancer, and chronic kidney disease, most of which represent a huge burden on public health...
    John R Grider; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Peristalsis is the main propulsive motility of the intestine and colon. The long term goal of this project has been to identify the components of the underlying reflex, the peristaltic reflex, and ..
  26. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): "Sporadic" colon cancer refers to >90% of colon cancer in the US and other developed countries...
  27. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
    ..1) definition of the structure of the fecal, respiratory or tissue microbiome in inflammatory bowel disease, colon and prostate cancer, progression of liver disease and transplant recipients with rejection and idiopathic lung ..
    Juanita L Merchant; Fiscal Year: 2013
    ..Mice conditionally null for ZBP-89 in the colon exhibited reduced numbers of EC cells and reduced tryptophan hydroxylase 1 gene (TPH1) transcripts on a microarray...
  29. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..tracing studies as well as preliminary electrophysiology recordings from our lab indicates that the bladder and colon are not only innervated by spinal afferents, but by the vagus nerve as well...
  30. Parental age at birth and risk of adult-onset cancer in female offspring
    Yani Lu; Fiscal Year: 2013
    ..1995 through 2009, the incident cases for the specific cancers to be studied are 5007 (breast), 1017 (lung), 843 (colon), 279 (rectal), 1031 (endometrial), 298 (thyroid), 195 (kidney), 486 (ovarian), 337 (pancreatic) and 761 (melanoma)..
  31. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    ..IBD;Crohn's disease;ulcerative colitis) are chronic inflammatory disorders of the small bowel and/or colon that affect approximately 1...
  32. Mechanisms of tumor suppressor gene reactivation in colon cancer by berries
    Li Shu Wang; Fiscal Year: 2013
    ..For persons with distant metastases at diagnosis, the 5-year survival is only 10%. Therefore, the prevention of colon cancer remains an important goal and chemoprevention is a viable approach to achieve this goal...
  33. Ionic currents in gastrointestinal smooth muscle
    Hamid I Akbarali; Fiscal Year: 2013
    ..and help identify novel therapeutic agents in the treatment of motility disturbances in the pathophysiology of the colon. PUBLIC HEALTH RELEVANCE: Colonic inflammation occurs in response to a variety of stimuli and results in smooth ..
  34. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
    ..difficile forms communities at the mucosa of the cecum and colon in mice with CDI, indicating that C. difficile forms a biofilm in the host. C...
    Ezra Burstein; Fiscal Year: 2013
    ..bowel disease;intestinal stem cells and malignant transformation in the GI tract, particularly the esophagus and colon;cancer prevention and screening;morphogenesis of the digestive system;obesity, liver steatosis, lipid metabolism ..
  36. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..Preliminary data suggest that non-pathogenic E. coli in the colon also upregulate expression of acid resistance genes, gadA and gadB, during colitis and that these genes inhibit ..
  37. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..effectiveness of PAC and PDAC prevention and also provide a foundation for improved prevention of cancer of the colon, prostate, breast, stomach and ovary, all of which are stimulated by beta-adrenergic signaling...
  38. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..reason why African Americans (AAs) have the highest incidence (c1:70,000 of the population) and death rate from colon cancer in the USA is due to dietary factors as native Africans, who consume a very different diet, hardly ever get ..
  39. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..These diseases are characterized by a pronounced infiltration of neutrophils (PMNs) into colon mucosal lesions, accompanied by epithelial cell necrosis and ulceration...
  40. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    ..Evidence supports the presence of sex-dependent immune activation in the colon that plays role in alterations of visceral sensitivity and epithelial functions...
  41. Adherent Escherichia coli and associated virulence genes in children with IBD
    Sandra C Kim; Fiscal Year: 2010
    ..coli - associated virulence factors from mucosal biopsy samples (a) in the ileum and different regions of the colon of children with Crohn's disease versus children with ulcerative colitis, and control individuals (normal ..
    Radhakrishna Rao; Fiscal Year: 2013
    ..8) MLCK mediates synergization of acetaldehyde-induced TJ disruption by ethanol. 9) Ethanol sensitizes mouse colon for acetaldehyde-induced barrier dysfunction by a c-Src and MLCK- dependent mechanism. 10) L...
  43. Metnase, PIKK, and RPA Roles in DNA Damage and Replication Stress Responses
    Jac A Nickoloff; Fiscal Year: 2013
    ..combinations of replication stress agents plus DDR inhibitors to enhance killing of breast, lung, pancreatic, colon, head and neck, and leukemic tumor cells...
  44. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..P450 polymorphisms and NAT2 polymorphisms contribute to risk of specific cancers, such as breast, pancreatic and colon. However, determining the risk of P450 and NAT polymorphisms in HCC is complicated by many modifying factors that ..
  45. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2013
  46. Best Management of Sigmoid Volvulus: a Prospective Randomized Trial
    JONATHAN CHARLES SAMUEL; Fiscal Year: 2013
    ..volvulus is necessary to provide the best care to patients with this and related conditions affecting the left colon such as sigmoid diverticulitis, and will advance surgicl sciences and benefit patients in both Malawi and the ..
  47. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..dietary intake of vitamin D and circulating vitamin D metabolites have been inversely associated with risk of colon, breast and other cancers in some, but not all, epidemiological studies...
  48. Gene-Targeted Pro-Drug Therapy for Colorectal Cancer
    Hiremagalur N Jayaram; Fiscal Year: 2013
    ..Standard therapy for metastatic colon cancer results in a median survival of 22 months...
  49. Inhibition of angiogenesis by thrombospondin-1 (A2)
    JOHN W LAWLER; Fiscal Year: 2012
    ..3TSR) and TNF-Related Apoptosis Inducing Ligand (TRAIL) can induce apoptosis of various tumor cells, including colon carcinomas, through the induction of endothelial cell apoptosis and tumor cell apoptosis, respectively...
  50. Regulation of Host Nitrogen Balance by the Gut Microbiome
    Gary D Wu; Fiscal Year: 2012
    ..Urea, produced by the host, is hydrolyzed in the colon by urease-producing gut bacteria and the resultant ammonia is absorbed by the host and utilized for protein ..
  51. Eotaxin in Colitis and Colitis-Associated Carcinogenesis
    Lori A Coburn; Fiscal Year: 2013
    ..consisting of ulcerative colitis (UC) and Crohn's disease, causes significant morbidity and can progress to colon cancer. While multiple predisposing factors have been identified, the cause or trigger for IBD remains unknown...
  52. Redox regulation of intestinal T cells
    ALAN DAVID LEVINE; Fiscal Year: 2010
    ..T cells isolated from the colon or small bowel normally respond very weakly when compared to T cells isolated from blood, while T cells isolated ..
  53. Hyperglycemia-induced DNA damage as a driver of genomic instability
    JOHN S TERMINI; Fiscal Year: 2013
    ..This condition significantly increases risk for cancers of the colon, liver, pancreas, kidney, breast, cervix, and endometrium;however, the mechanisms responsible remain unknown...
  54. Human Papillomavirus Association with Subsets of Colorectal Cancer
    Polly A Newcomb; Fiscal Year: 2010
    ..the anal canal, a site known to be associated with HPV-related malignancies, leads directly into the rectum and colon, several studies have examined colorectal neoplastic tissue for HPV DNA...
  55. Organic Cation Transporter PMAT: Physiological Function and Role in Drug Disposit
    Joanne Wang; Fiscal Year: 2013
    ..More excitingly, the PMAT null mice exhibited physiological and histological abnormalities in the colon which could represent early signs associated with the development of inflammatory bowel disease...
  56. Gender Selectivity to Colon Cancer Chemoprevention by NSAIDS
    RAMESH K contact WALI; Fiscal Year: 2010
    ..These findings will have an important bearing on the healthcare recommendations for colon cancer chemoprevention which have to be cognizant of this gender selective efficacy for maximum cost-benefit ..
  57. Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta
    Iona Cheng; Fiscal Year: 2012
    ..Aim 3 will evaluate whether mtDNA effects are modified by disease sub-groups (stage, grade, ER+/- breast tumors, colon/rectum tumors), environmental factors related to mitochondrial activity (smoking, BMI, fat, carotenoids, vitamin C,..
  58. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
    ..e. of a different tumor lineage including melanoma and colon cancer)...
  59. Molecular Analysis of Alcohol Effects on Human Oral Epithelium Cells'Epigenome
    Alison Urvalek; Fiscal Year: 2013
    ..Alcohol and its metabolite acetaldehyde (AcH) promote epigenetic changes in breast, liver, and colon cancers, but whether or not genome-wide epigenetic changes are induced by alcohol in oral epithelial cells is ..
  60. Prevention of EtOH-induced promotion of hepatocarcinogenesis by genistein/soy
    Martin J J Ronis; Fiscal Year: 2013
    ..genistein have been shown to block activation of Wnt-b-catenin signaling in several tissues including breast and colon. We will test the hypotheses that 1) The carcinogen diethylnitrosamine (DEN) and ETOH will act additively to ..
  61. PLCgamma regulates HNE3 activity through direct binding and dynamic complexes
    NICHOLAS CONSTANTINE ZACHOS; Fiscal Year: 2011 neurohumoral substances and bacterial toxins results in decreased sodium absorption in the intestine and colon. The sodium/hydrogen exchanger (NHE) gene family plays an integral role in sodium absorption in the mammalian ..
  62. (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon Cancer
    Yan Chun Li; Fiscal Year: 2013
    ..of osteoporosis, but a growing body of evidence has indicated that VD has potent chemopreventive effects against colon cancer by unknown mechanisms...
  63. Antifibrotic Therapy to Improve Immune reconstitution in HIV
    Timothy W Schacker; Fiscal Year: 2013
    ..Further, the increasing incidence of non-AIDS related cancer deaths from colon or lung cancer and non-AIDS associated lymphoma among HIV+ persons treated with ARV highlight the need for ..
  64. USC Research Center for Liver Disease
    Neil Kaplowitz; Fiscal Year: 2013
    ..1 million in annual direct costs. These Themes include: a) viral hepatitis, hepatocellular and colon cancer: b) liver injury: c) cell biology, signal transduction and transport: d) regulatory biology: liver ..
  65. Preclinical assay development of a novel Colon Cancer Marker (CCSA-4)
    JACK CLEMENS; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Colon cancer is one of the most common cancers worldwide and is the third most diagnosed cancer in the United States...
  66. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009
    The central hypothesis to be tested in this proposal is that bile acids induce colon cancer cell proliferation by interaction with M3 muscarinic receptors (M3R), thereby causing transactivation of epidermal growth factor receptors (EGFR)..
  67. Diet and the Calcium Channel TRPV6 in Colon Hyperplasia
    Sara Peleg; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Inflammatory bowel disease (IBD) increases the risk of colon cancer...
  68. S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancer
    GEETHA K SRIKRISHNA; Fiscal Year: 2010
    ..receptors and ligands that bind to them mediate intracellular activation, gene expression and inflammation-induced colon cancers...
  69. Refinement of LC/ESR/MS for Studying Lipid Free Radicals in Colon Cancer Growth
    Steven Qian; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Colon cancer remains a significant health concern as the third most prevalent cancer and the second leading cause of cancer deaths in the United States. Two lipid peroxidizing enzymes, e.g...
  70. Gamma-tocopherol as an effective anticancer agent for colon cancer
    Qing Jiang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Colon cancer is the second leading cause of cancer deaths in the United States. Chronic inflammation contributes significantly to the etiology of colon cancer development...
    Lynne Ausman; Fiscal Year: 1991
    ..Saguinus oedipus) (Sgo) shows a high incidence of spontaneous colitis and subsequent adenocarcinoma of the colon after 5 years of life...
  72. Studies of a Novel CCK-B/Gastrin Receptor Splice Variant
    MARK HELLMICH; Fiscal Year: 2005
    ..Applicant's Abstract): Colorectal cancer is the third leading cause of cancer death in the United States, Colon carcinogenesis is a complex, multi-step process involving progressive changes in signaling pathways regulating ..
  73. Cancer Prevention by West African Medicinal Plants
    Michael Wargovich; Fiscal Year: 2007 to establish a role for this unexploited source of natural products for future chemoprevention applications for colon and other cancers...
    TAUBE ROTHMAN; Fiscal Year: 2000
    ..The expression of this receptor is a mark of differentiation. In the ls/ls mouse the terminal colon is aganglionic and extracellular matrix molecules including laminin are overexpressed in the colon...
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1999
    ..effects of dietary intake, physical activity, body size, reproductive factors, and family history on the risk of colon cancer in whites is proposed...
  76. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
    ..remained elusive, Recent data suggests that the PPAR-beta may be involved in epithelial cancer including skin and colon. PPAR-beta expression is upregulated in response to topical application of a tumor promoter (TPA), in human colon ..
  77. ELSI Issues: Colon Cancer and Cancer Genomics Research
    Patricia A Marshall; Fiscal Year: 2010
    ..The empirical goal of this study is to describe the effect of being a colon cancer patient, compared to being a patient without a cancer history, on attitudes toward cancer genomics research ..
  78. Critical Role of Mybl2 in Spontaneous and Short-Chain Fatty Acid-Induced Intestin
    MICHAEL JOSEPH PAPETTI; Fiscal Year: 2011
    ..This process is recapitulated in immortalized cell lines derived from human colon adenocarcinomas that proliferate in an immature state in culture yet can be induced by the short chain fatty acid (..
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    The overall objective of the proposal is to elucidate the inhibitory mechanisms in colon carcinogenesis by the naturally occurring agents curcumin and phenylethyl-3-methylcaffeate (PEMC)...
  80. Colon Polyp Surveillance with DNA Analysis of Stool
    Philip Schoenfeld; Fiscal Year: 2003
    DESCRIPTION: Clinical practice guidelines state that individuals with a history of colon adenomas should undergo surveillance colonoscopy to identify and remove newly formed colon adenomas...
  81. A web-based tailored health behavior intervention for African American colon canc
    Marlyn Allicock; Fiscal Year: 2010
    ..provided by applicant): Background African Americans experience disproportionate morbidity and mortality from colon and rectal cancers...