Genomes and Genes
Summary: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Publications314 found, 100 shown here
- The chemokine system in diverse forms of macrophage activation and polarizationAlberto Mantovani
Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
Trends Immunol 25:677-86. 2004....
- Blood monocytes consist of two principal subsets with distinct migratory propertiesFrederic Geissmann
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Immunity 19:71-82. 2003Peripheral blood monocytes are a heterogeneous population of circulating leukocytes...
- Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expressionFernando O Martinez
Istituto Clinico Humanitas, Rozzano, Italy
J Immunol 177:7303-11. 2006..is associated with activation of cell cycle genes, substantiating the underestimated proliferation potential of monocytes. 2) M-CSF leads to expression of a substantial part of the M2 transcriptome, suggesting that under homeostatic ..
- Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia poolBahareh Ajami
University of British Columbia, Biomedical Research Centre, Vancouver, British Columbia, Canada
Nat Neurosci 14:1142-9. 2011..Inhibition of chemokine receptor-dependent recruitment of monocytes to the CNS blocked EAE progression, suggesting that these infiltrating cells are essential for pathogenesis...
- Endotoxin tolerance: new mechanisms, molecules and clinical significanceSubhra K Biswas
Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, 04 01 Immunos, 8A Biomedical Drive, 138648 Singapore
Trends Immunol 30:475-87. 2009Prior exposure of innate immune cells like monocytes/macrophages to minute amounts of endotoxin cause them to become refractory to subsequent endotoxin challenge, a phenomenon called "endotoxin tolerance"...
- Nomenclature of monocytes and dendritic cells in bloodLoems Ziegler-Heitbrock
Helmholtz Zentrum Munchen, Gauting, Germany
Blood 116:e74-80. 2010b>Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense...
- Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophagesGuillaume Hoeffel
Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
J Exp Med 209:1167-81. 2012..which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis...
- Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasisSimon Yona
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Immunity 38:79-91. 2013Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense...
- Genetics and beyond--the transcriptome of human monocytes and disease susceptibilityTanja Zeller
Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
PLoS ONE 5:e10693. 2010....
- Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromataFilip K Swirski
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Clin Invest 117:195-205. 2007..Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative contribution to ..
- Monocyte recruitment during infection and inflammationChao Shi
Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Nat Rev Immunol 11:762-74. 2011b>Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues...
- Monocyte chemoattractant protein-1 (MCP-1): an overviewSatish L Deshmane
Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Interferon Cytokine Res 29:313-26. 2009..Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled ..
- PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory propertiesM Amine Bouhlel
Institut Pasteur de Lille, F 59019 Lille, France INSERM, U545, F 59019 Lille, France
Cell Metab 6:137-43. 2007..Moreover, PPARgamma activation primes primary human monocytes into M2 differentiation, resulting in a more pronounced anti-inflammatory activity in M1 macrophages...
- In vivo analysis of dendritic cell development and homeostasisKang Liu
Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
Science 324:392-7. 2009Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs)...
- Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory responseCord Sunderkotter
Institute of Experimental Dermatology and Department of Dermatology, University of Munster, Munster, Germany
J Immunol 172:4410-7. 2004Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known...
- Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areasCheolho Cheong
Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
Cell 143:416-29. 2010..critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into cells with critical features of ..
- Identification of splenic reservoir monocytes and their deployment to inflammatory sitesFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Science 325:612-6. 2009A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry...
- Monocyte-mediated defense against microbial pathogensNatalya V Serbina
Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Annu Rev Immunol 26:421-52. 2008Circulating blood monocytes supply peripheral tissues with macrophage and dendritic cell (DC) precursors and, in the setting of infection, also contribute directly to immune defense against microbial pathogens...
- Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditionsAlexander Mildner
Institute of Neuropathology, Georg August University, Gottingen, Germany
Nat Neurosci 10:1544-53. 2007..a panel of bone marrow chimeric and adoptive transfer experiments, we found that circulating Ly-6C(hi)CCR2(+) monocytes were preferentially recruited to the lesioned brain and differentiated into microglia...
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasisBin Zhi Qian
Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
Nature 475:222-5. 2011..Here we define the origin of these macrophages by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice...
- Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytesJohanneke Kleinnijenhuis
Department of Medicine, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
Proc Natl Acad Sci U S A 109:17537-42. 2012..The enhanced function of circulating monocytes persisted for at least 3 mo after vaccination and was accompanied by increased expression of activation markers ..
- How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytesYanfang Guo
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
Acta Biochim Biophys Sin (Shanghai) 40:426-36. 2008..We carried out correlation analyses on mRNA-protein expressions in freshly isolated human circulating monocytes from 30 unrelated women...
- Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitorsMichele De Palma
Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, Milano, Italy
Cancer Cell 8:211-26. 2005Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs]) (1) are a distinct hematopoietic lineage of proangiogenic cells, (2) are ..
- Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteriaFrank A W Verreck
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
Proc Natl Acad Sci U S A 101:4560-5. 2004..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
- Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotidesVeit Hornung
Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
J Immunol 168:4531-7. 2002..High expression of TLR2 was characteristic for monocytes. PDC and B cells expressed marked levels of TLR7 and TLR9 and were directly sensitive to CpG ODN...
- Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytesA Bouchon
Basel Institute for Immunology, Basel, Switzerland
J Immunol 164:4991-5. 2000..TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS...
- Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaquesFrank Tacke
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
J Clin Invest 117:185-94. 2007b>Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR2(+)CX3CR1(+)Ly-6C(hi) and CCR2(-)CX3CR1(++)Ly-6C(lo) monocytes...
- Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptorsJerome Cros
U838 INSERM, Universite Paris Descartes, Paris, France
Immunity 33:375-86. 2010b>Monocytes are effectors of the inflammatory response to microbes...
- Mechanisms of uremic erythrocyte-induced adhesion of human monocytes to cultured endothelial cellsAssunta Pandolfi
Department of Biomorphology, University G D Annunzio, Aging Research Center, Ce S I, G d Annunzio University Foundation, Chieti Pescara, Italy
J Cell Physiol 213:699-709. 2007..Thus, intervention targeting ESRD-RBC increased adhesion to endothelium and/or MAPK and Akt/eNOS pathways may have the potential to prevent vascular lesions under uremic conditions...
- Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sitesChia Lin Tsou
Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94158, USA
J Clin Invest 117:902-9. 2007..However, the mechanisms that govern the migration of monocytes from bone marrow to blood and from blood to inflamed tissues are not well understood...
- Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivoMarie Luise von Brühl
Deutsches Herzzentrum and I Medizinische Klinik, Technische Universität München TUM, 80333 Munich, Germany
J Exp Med 209:819-35. 2012..We demonstrate by intravital two-photon and epifluorescence microscopy that blood monocytes and neutrophils crawling along and adhering to the venous endothelium provide the initiating stimulus for DVT ..
- Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cellsVishwa Deep Dixit
Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
J Clin Invest 114:57-66. 2004..Here we report that GHS-R and ghrelin are expressed in human T lymphocytes and monocytes, where ghrelin acts via GHS-R to specifically inhibit the expression of proinflammatory anorectic cytokines such ..
- NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responsesKonstantin D Taganov
Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 103:12481-6. 2006..Expression profiling of 200 microRNAs in human monocytes revealed that several of them (miR-146a/b, miR-132, and miR-155) are endotoxin-responsive genes...
- The CD14+ CD16+ blood monocytes: their role in infection and inflammationLoems Ziegler-Heitbrock
Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
J Leukoc Biol 81:584-92. 2007Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes...
- Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammationStephen J Jenkins
Centre for Immunity, Infection and Evolution, and the Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
Science 332:1284-8. 2011..Thus, expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells...
- Use of Ly6G-specific monoclonal antibody to deplete neutrophils in miceJean M Daley
Department of Surgery, Division of Surgical Research, Rhode Island Hospital, NAB 214, 593 Eddy Street, Providence, RI 02903, USA
J Leukoc Biol 83:64-70. 2008..and to Ly6C, which is expressed on neutrophils, dendritic cells, and subpopulations of lymphocytes and monocytes. It is thus likely that in vivo administration of RB6-8C5 may deplete not only neutrophils but also other Gr-l+ (..
- The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophagesMarc Daigneault
Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
PLoS ONE 5:e8668. 2010..cell line after various protocols of differentiation utilising VD(3) and PMA in comparison to primary human monocytes or monocyte-derived macrophages (MDM)...
- PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytesRasmus Foldbjerg
Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
Toxicol Lett 190:156-62. 2009..A drastic increase in ROS levels could be detected after 6-24h suggesting that oxidative stress is an important mediator of cytotoxicity caused by Ag NPs and Ag+...
- Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cellsJorge Reyes-Del Valle
Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Av I P N 2508, Col San Pedro Zacatenco, Mexico City D F, C P 07360, Mexico
J Virol 79:4557-67. 2005..Based on the ability of HSP90 (84 kDa) to interact with HSP70 (74 kDa) on the surface of monocytes during lipopolysaccharide (LPS) signaling and evidence that LPS inhibits dengue virus infection, the presence of ..
- Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signalsFlavia Bazzoni
Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
Proc Natl Acad Sci U S A 106:5282-7. 2009..study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes. In particular, we identify miR-9 as the only miRNA (among 365 analyzed) up-regulated in both cell types after ..
- Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1B Barleon
Institute of Molecular Medicine, Tumor Biology Center Freiburg, Germany
Blood 87:3336-43. 1996Treatment of human monocytes with vascular endothelial growth factor (VEGF) isolated from tumor cell supernatants was reported to induce monocyte activation and migration...
- Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigmSubhra K Biswas
Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
Nat Immunol 11:889-96. 2010..A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention...
- Type I interferon inhibits interleukin-1 production and inflammasome activationGreta Guarda
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Immunity 34:213-23. 2011..Importantly, monocytes from multiple sclerosis patients undergoing IFN-β treatment produced substantially less IL-1β than monocytes ..
- Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuliC Buechler
Institut fur Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universitat Regensburg, Germany
J Leukoc Biol 67:97-103. 2000..In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets...
- Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic miceChristophe Combadiere
Institut National de la Sante et de la Recherche Medicale, Unit 543, Universite Pierre et Marie Curie, Paris 6, Paris, France
Circulation 117:1649-57. 2008b>Monocytes are critical mediators of atherogenesis...
- Macrophage activation switching: an asset for the resolution of inflammationF Porcheray
Laboratoire de Neuro Immuno Virologie, Service de Neurovirologie UMR E1, Universite Paris Sud, Centre de Recherches du Service de Sante des Armees, IPSC, Fontenay aux Roses, France
Clin Exp Immunol 142:481-9. 2005..However, it is not known whether the resolution of inflammation requires alternative activation of new resting monocytes/macrophages or if proinflammatory activated macrophages have the capacity to switch their activation towards ..
- Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infectionXu Wang
Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Blood 113:671-4. 2009Although both monocytes and macrophages possess essential requirements for HIV-1 entry, peripheral blood monocytes are infrequently infected with HIV-1 in vivo and in vitro...
- Monocytes in atherosclerosis: subsets and functionsKevin J Woollard
Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
Nat Rev Cardiol 7:77-86. 2010..Plaque macrophages account for the majority of leukocytes in plaques, and are believed to differentiate from monocytes recruited from circulating blood. However, monocytes represent a heterogenous circulating population of cells...
- Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytesJulie Schulthess
INSERM, U989, 75015 Paris, France Université Paris Descartes, Paris Sorbonne Cité, Institut Imagine, France
Immunity 37:108-21. 2012..that a crosstalk between IL-15 and interleukin-18 (IL-18) promoted intestinal recruitment of inflammatory monocytes, where these cells participated in parasite control but also in tissue damage...
- NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infectionRomina S Goldszmid
Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Immunity 36:1047-59. 2012Dendritic cells (DCs), monocytes, and/or macrophages initiate host-protective immune responses to intracellular pathogens in part through interleukin-12 (IL-12) production, although the relative contribution of tissue resident versus ..
- Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulationA R R Forrest
LSA Technology Development Unit, Omics Science Center, RIKEN Yokohama Institute, Yokohama, Kanagawa, Japan
Leukemia 24:460-6. 2010..Our study highlights the combinatorial effects of multiple microRNAs within cellular systems...
- beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosisC K Combs
Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Neurosci 21:1179-88. 2001..Importantly, TNFalpha generated by the monocytes and microglia was responsible for the majority of the neuorotoxic activity secreted by these cells after beta-..
- Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humansMaxime Rotival
INSERM UMRS 937, Pierre and Marie Curie University UPMC, Paris 6 and Medical School, Paris, France
PLoS Genet 7:e1002367. 2011..multiple expression traits was replicated in Cardiogenics, an independent study in which expression profiles of monocytes were available in 758 subjects...
- Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodesSamuele Calabro
Novartis Vaccines and Diagnostics, Siena, Italy
Vaccine 29:1812-23. 2011..The earliest and most abundantly recruited cell type are neutrophils, followed by monocytes, eosinophils and later dendritic cells (DCs) and macrophages...
- The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functionsMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Exp Med 204:3037-47. 2007Healing of myocardial infarction (MI) requires monocytes/macrophages...
- Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursorsC C Bain
Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK
Mucosal Immunol 6:498-510. 2013..Ly6C(hi)CCR2(+) monocytes can give rise to all mφ subsets in both healthy and inflamed colon and we show that the CX3CR1(int) pool ..
- Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineageMatthew M Meredith
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
J Exp Med 209:1153-65. 2012Classical dendritic cells (cDCs), monocytes, and plasmacytoid DCs (pDCs) arise from a common bone marrow precursor (macrophage and DC progenitors [MDPs]) and express many of the same surface markers, including CD11c...
- Monitoring of blood vessels and tissues by a population of monocytes with patrolling behaviorCedric Auffray
Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
Science 317:666-70. 2007..We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium...
- LPS induction of gene expression in human monocytesM Guha
Departments of Immunology, C-204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Signal 13:85-94. 2001..Recent studies have elucidated how LPS is recognized by monocytes and macrophages of the innate immune system...
- Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapyAntonio Sica
Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
Eur J Cancer 42:717-27. 2006..Evidence is presented here supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and are a potential target for anti-cancer therapy...
- Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colonAymeric Rivollier
Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 209:139-55. 2012..In noninflammatory conditions, Ly6C(hi) monocytes (MOs) differentiated primarily into CD11c(+) but not CD11c(-) MPs...
- The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse modelsChristian Weber
Institute for Molecular Cardiovascular Research, RWTH Aachen University, 52074 Aachen, Germany
Nat Rev Immunol 8:802-15. 2008..Improved understanding of the selective contributions of specific cell types to atherogenesis will pave the way for new targeted approaches to therapy...
- CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitisSamira Tamoutounour
Centre d immunologie de Marseille Luminy, Aix Marseille Universite, Marseille, France
Eur J Immunol 42:3150-66. 2012..and we delineate a developmental pathway in the healthy intestine that leads from newly extravasated Ly-6C(hi) monocytes to intestinal MΦs...
- Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodesClaudia Jakubzick
Department of Pediatrics at National Jewish Health, Denver, CO 80206, USA Integrated Department of Immunology, University of Colorado, Denver, CO 80206, USA Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunity 39:599-610. 2013It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs) upon leaving blood. Here we have shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs)...
- Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2Natalya V Serbina
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
Nat Immunol 7:311-7. 2006b>Monocytes recruited to tissues mediate defense against microbes or contribute to inflammatory diseases. Regulation of the number of circulating monocytes thus has implications for disease pathogenesis...
- Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cellsEhud Zigmond
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Immunity 37:1076-90. 2012Ly6C(hi) monocytes seed the healthy intestinal lamina propria to give rise to resident CX(3)CR1(+) macrophages that contribute to the maintenance of gut homeostasis. Here we report on two alternative monocyte fates in the inflamed colon...
- Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSFMartin Guilliams
Laboratory of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, 9050 Ghent, Belgium
J Exp Med 210:1977-92. 2013Tissue-resident macrophages can develop from circulating adult monocytes or from primitive yolk sac-derived macrophages. The precise ontogeny of alveolar macrophages (AMFs) is unknown...
- Experimental human cytomegalovirus latency in CD14+ monocytesDanna Hargett
Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
Proc Natl Acad Sci U S A 107:20039-44. 2010CD14(+) monocytes are a reservoir for latent human cytomegalovirus, and virus replication is reactivated during their differentiation to macrophages or dendritic cells...
- Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidinJae Min Yuk
Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
Cell Host Microbe 6:231-43. 2009..We show that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophagy-related genes Beclin-1 and Atg5...
- Monocyte and macrophage heterogeneitySiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Rev Immunol 5:953-64. 2005..Circulating monocytes give rise to mature macrophages and are also heterogeneous themselves, although the physiological relevance of ..
- Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient miceL Gu
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Mol Cell 2:275-81. 1998Recruitment of blood monocytes into the arterial subendothelium is one of the earliest steps in atherogenesis. Monocyte chemoattractant protein-1 (MCP-1), a CC chemokine, is one likely signal involved in this process...
- TREM-1 amplifies inflammation and is a crucial mediator of septic shockA Bouchon
Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
Nature 410:1103-7. 2001Host innate responses to bacterial infections are primarily mediated by neutrophils and monocytes/macrophages...
- Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergenMaud Plantinga
Laboratory of Immunoregulation and Mucosal Immunology, Department for Molecular Biomedical Research, VIB, Ghent 9050, Belgium
Immunity 38:322-35. 2013..Thus, we have identified migratory CD11b(+) cDCs as the principal subset inducing Th2 cell-mediated immunity in the LN, whereas moDCs orchestrate allergic inflammation in the lung...
- LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells- De Yang
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick, MD, USA
J Exp Med 192:1069-74. 2000..Here we report that LL-37 is chemotactic for, and can induce Ca(2+) mobilization in, human monocytes and formyl peptide receptor-like 1 (FPRL1)-transfected human embryonic kidney 293 cells...
- C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in transCarmen P Alvarez
Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
J Virol 76:6841-4. 2002..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
- ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine wayAlessandra Piccini
Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
Proc Natl Acad Sci U S A 105:8067-72. 2008..Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid ..
- CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient miceFlorian Sennlaub
INSERM, U 968, Paris, France UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, France Centre Hospitalier National d Ophtalmologie des Quinze Vingts, INSERM DHOS CIC 503, Paris, France Hôtel Dieu, Service d Ophtalmologie, Centre de Recherche Ophtalmologique, Paris, France
EMBO Mol Med 5:1775-93. 2013..in the retina where it represses the expression of CCL2 and the recruitment of neurotoxic inflammatory CCR2(+) monocytes. CCL2/CCR2 inhibition might represent a powerful tool for controlling inflammation and neurodegeneration in AMD.
- HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapyAnna C Hearps
Centre for Virology, Burnet Institute, Melbourne, Australia
AIDS 26:843-53. 2012..To compare the impact of HIV infection and healthy ageing on monocyte phenotype and function and determine whether age-related changes induced by HIV are reversed in antiretroviral treated individuals...
- Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytesSalik Hussain
Clinical Research Unit, National Institute of Environmental Health Sciences National Institute of Health, Research Triangle Park 27709, North Carolina, United States
ACS Nano 6:5820-9. 2012..We aimed at characterizing the cytotoxic effects of CeO(2) NPs in human peripheral blood monocytes. CeO(2) NPs and their suspensions were thoroughly characterized, including using transmission electron ..
- Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALSOleg Butovsky
Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 122:3063-87. 2012..Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes were activated and that their progressive recruitment to the spinal cord, but not brain, correlated with ..
- Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarctionA D Michelson
Center for Platelet Function Studies, Departments of Pediatrics and Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Circulation 104:1533-7. 2001..Platelet surface P-selectin is considered the "gold standard" marker of platelet activation. Degranulated, P-selectin-positive platelets, however, aggregate with leukocytes in vitro and rapidly lose surface P-selectin in vivo...
- Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytesXu Wang
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
Am J Pathol 178:41-7. 2011..heroin), widely abused drugs among people infected with HIV, on the expression of cellular anti-HIV miRNAs in monocytes. We found that morphine-treated monocytes expressed lower levels of cellular anti-HIV miRNAs than untreated ..
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cellsDong Ming Kuang
State Key Laboratory of Oncology in Southern China, Cancer Center, Guangzhou, P R China
Hepatology 51:154-64. 2010..Most peritumoral CD68(+) cells exhibited an activated phenotype. Accordingly, tumor-activated monocytes were significantly superior to the suppressive tumor macrophages in inducing expansion of Th17 cells from ..
- Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesisLudovic Arnold
Institut National de la Sante et de la Recherche Medicale, Unite 841, Institut Mondor de Recherche Biomedicale, Cell Interactions in the Neuromuscular System Team, Universite Paris 12 Val de Marne, Creteil, France
J Exp Med 204:1057-69. 2007..In conclusion, injured skeletal muscle recruits MOs exhibiting inflammatory profiles that operate phagocytosis and rapidly convert to antiinflammatory MPs that stimulate myogenesis and fiber growth...
- Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administrationJoanna Mikita
University Victor Segalen, France
Mult Scler 17:2-15. 2011We investigated proinflammatory M1 and immunomodulatory M2 activation profiles of circulating monocytes in relapsing experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, and tested whether altered M1/M2 ..
- Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaBY Ogura
Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Biol Chem 276:4812-8. 2001..Although Nod1 and Apaf-1 were broadly expressed in tissues, the expression of Nod2 was highly restricted to monocytes. Nod2 induced nuclear factor kappaB (NF-kappaB) activation, which required IKKgamma and was inhibited by ..
- Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activationAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Gastroenterology 127:1513-24. 2004..reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) proteins activate inflammatory pathways in monocytes. The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 ..
- miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1Tzu Ling Sung
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
PLoS Pathog 5:e1000263. 2009..Translation of Cyclin T1 mRNA has been shown to be repressed in human monocytes, and this repression is relieved when cells differentiate to macrophages...
- The phagocytes: neutrophils and monocytesDavid C Dale
Department of Medicine, University of Washington School of Medicine, Seattle A98195, USA
Blood 112:935-45. 2008..demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells...
- A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationshipsFerdinando Pucci
Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, Olgettina 58, Milan, Italy
Blood 114:901-14. 2009We previously showed that Tie2-expressing monocytes (TEMs) have nonredundant proangiogenic activity in tumors...
- Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophagesMihai G Netea
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Blood 113:2324-35. 2009..Here we demonstrate that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from ..
- miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITYMd A Nahid
Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
J Biol Chem 284:34590-9. 2009..Thus our studies demonstrated that miR-146a is critical for the in vitro monocytic cell-based endotoxin tolerance...
- Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapyI Jolanda M de Vries
Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
Nat Biotechnol 23:1407-13. 2005..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
- Candida albicans infection affords protection against reinfection via functional reprogramming of monocytesJessica Quintin
Department of Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
Cell Host Microbe 12:223-32. 2012..C. albicans and fungal cell wall β-glucans induced functional reprogramming of monocytes, leading to enhanced cytokine production in vivo and in vitro...
- GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cellsMelanie Greter
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunity 36:1031-46. 2012..Thus, Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo...
- High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytesU Andersson
Department of Medicine, Rheumatology Unit, Karolinska Hospital, 17176 Stockholm, Sweden
J Exp Med 192:565-70. 2000..HMG-1 concentrations that activated monocytes were within the pathological range previously observed in endotoxemic animals, and in serum obtained from septic ..
- Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposalLeo M Carlin
Centre for Molecular and Cellular Biology of Inflammation, King s College London, London SE1 1UL, UK
Cell 153:362-75. 2013The functions of Nr4a1-dependent Ly6C(low) monocytes remain enigmatic. We show that they are enriched within capillaries and scavenge microparticles from their lumenal side in a steady state...
- Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretionTiziana Bonaldi
DIBIT, San Raffaele Scientific Institute, San Raffaele University, Via Olgettina 58, 20132 Milan, Italy
EMBO J 22:5551-60. 2003..HMGB1 can also be secreted by activated monocytes and macrophages, and functions as a late mediator of inflammation...
- Monocytes and macrophages in malaria: protection or pathology?Caroline Lin Lin Chua
The University of Melbourne, Department of Medicine Royal Melbourne Hospital, Parkville, Australia
Trends Parasitol 29:26-34. 2013Recruitment and activation of monocytes and macrophages are essential for clearance of malaria infection, but these have also been associated with adverse clinical outcomes...
- Development of monocytes, macrophages, and dendritic cellsFrederic Geissmann
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 327:656-61. 2010b>Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system...
- Generation of nitric oxide and reactive oxygen species by neutrophils and monocytes from septic patients and association with outcomesSidnéia Sousa Santos
Division of Infectious Diseases, Department of Medicine, Hospital Sao Paulo, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Shock 38:18-23. 2012In this study, our aims were to evaluate the reactive oxygen species (ROS) and nitric oxide (NO) generation by monocytes and neutrophils from septic patients and to correlate their levels with clinical outcomes...
- THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSISWilliam Boisvert; Fiscal Year: 2002..First they will determine if retention of lesion monocytes is greater in LDLR-/-, mIL-8RH+/+ than LDLR-/-, mIL-8RH-/- mice...
- HO-1 and granuloma formation in TB pleurisyVeena B Antony; Fiscal Year: 2010..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..NSP is expressed by neurons, monocytes, and multiple organs, and is reported to reduce stroke volume in rodent models and in recent work from our lab, ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2011..disruption of gram negative microbial biofilm formation, inhibition of cytokine secretion by LPS-stimulated monocytes, and inhibition of matrix metalloproteinase (MMP) production by interleukin-12 (IL-12)-stimulated gingival ..
- Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)James D Bryers; Fiscal Year: 2012..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections ..
- Correction of glutathione deficiency for treatment of diabetic nephropathyPaolo Fanti; Fiscal Year: 2013..Circulating monocytes participate to this process since these cells carry a high oxidative burden and are found in diabetic renal ..
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2013....
- Antiphospholipid antibodies and lupus: new molecular targets for treatmentEmilio B Gonzalez; Fiscal Year: 2013..22GPI binds to target cells [i.e.: endothelial cells (EC), platelets, monocytes] through domain V and trigger an intracellular signaling and a pro-coagulant and pro-inflammatory phenotype [i e...
- Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of SclerodRobert B Zurier; Fiscal Year: 2012..b>Monocytes and activated T lymphocytes dominate the early inflammatory infiltrates...
- Immunomodulatory and regenerative effects of mesenchymal stem cells on allograftsNorma S Kenyon; Fiscal Year: 2013..infusion of IV MSC post-transplant will result in the induction of T regulatory cells, recruitment of regulatory monocytes/macrophages and endothelial precursors to sites of inflammation (i.e...
- Biology and Pathologies of Type V CollagenDaniel S Greenspan; Fiscal Year: 2013..If such studies are borne out, the ramifications are huge, with profound implications for understanding, evaluating and treating atherosclerotic disease - the number one killer of adult human beings in the western hemisphere. ..
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2010..abstract_text> ..
- Identification of Proteins Important for Male OsteoporosisHong Wen Deng; Fiscal Year: 2013..Bone marrow mesenchymal stem cells (BMMSCs) and peripheral blood monocytes (PBMs) are precursors for osteoblasts (bone formation cells) and osteoclasts (bone resorption cells), ..
- Monocyte activation and the role of CD11c in obesity-linked metabolic syndromeHuaizhu Wu; Fiscal Year: 2013..CD11c is a b2 integrin primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2013..Third, it inhibits P. gingivalis LPS-induced formation of multinucleated osteoclasts from blood monocytes. Fourth, it reduces TNF-[unreadable], IL-1[unreadable], IL-6, and MMP-2 and -9 levels in gingival extracts from ..
- The Role of Decidual Innate Immunity in the Pathogenesis of PreeclampsiaSe Te Joseph Huang; Fiscal Year: 2012..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
- Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1RAJESH K ANEJA; Fiscal Year: 2013..In Aim 1, we determine the molecular mechanisms whereby PARP-1 regulates LPS-induced HMGB1 secretion in monocytes. We hypothesize that 1) chemical and genetic PARP-1 inhibition modulates mitogen-activated protein kinase (MAPK) ..
- The Role of Vascular MR-Regulated Genes in Vascular Function and DiseaseIris Z Jaffe; Fiscal Year: 2013..abstract_text> ..
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2013..3. Evaluate the interaction of FABPs with LTA4 and LTA4 metabolizing enzymes. 4. Examine the effects of leukotrienes on macrophage and adipocyte signal transduction and cytokine synthesis. ..
- N-Acetylcysteine and Milk Thistle for Treatment of Diabetic NephropathyPaolo Fanti; Fiscal Year: 2011..Circulating monocytes participate to this process since these cells carry a high oxidative burden and are found in diabetic renal ..
- ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURYIrfan Rahman; Fiscal Year: 2013..We propose to test this hypothesis in vitro in monocytes/macrophages (the main orchestrators and amplifiers of the lung inflammatory response) and in vivo in mouse lungs ..
- Role of the neurogenic inflammatory pathway in the genital tract immune responseRoger G Rank; Fiscal Year: 2010..Chemotactic factors produced as a result of substance P release recruit neutrophils, monocytes, macrophages, and lymphocytes to the local site...
- Knockdown of Gene Expression in Immune Cells in Humanized MiceJudy Lieberman; Fiscal Year: 2010..Our first aim is to test and optimize CD4- AsiCs for systemic knockdown of gene expression in CD4 T cells, monocytes and macrophages...
- Citrulline to Prevent or Mitigate Acute Lung Injury in Severe SepsisTodd W Rice; Fiscal Year: 2013..These ROS stimulate monocytes to produce and release additional pro-inflammatory cytokines, further propagating and prolonging the ..
- Anti-Bacterial Innate Responses Enhance Paramyxovirus ReplicationGriffith D Parks; Fiscal Year: 2010..Our studies are innovative, as they show that "anti-microbial" signaling can actually create environments that promote virus replication, particularly for viral mutants which would otherwise be restricted. ..
- Study of zidovudine addition in HIV-associated neurocognitive disordersAlbert Anderson; Fiscal Year: 2013..whether subjects with HAND randomized to zidovudine, which has demonstrated antiretroviral activity within monocytes, have less peripheral monocyte activation...
- Phenotyping Major Depression with Increased InflammationAndrew H Miller; Fiscal Year: 2013..abstract_text> ..
- Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD RiskChristopher D Gardner; Fiscal Year: 2010....
- CT Evaluation of the Myocardial Effects of Risk FactorsLilach O Lerman; Fiscal Year: 2013..The proposed studies could contribute towards our understanding of the cardiovascular effects of the metabolic syndrome, and towards development of imaging strategies for assessment of its evolution and mechanisms. ..
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2011..3. Assess the role of fatty acid binding proteins in leukotriene biosynthesis. 4. Examine the effect of leukotrienes on adipocyte and macrophage signal transduction and metabolism. ..
- Hypertension and Collagen: Effect of Ac-SDKPNour Eddine Rhaleb; Fiscal Year: 2010..Consequently, it will identify another component (Ac-SDKP) as part of the multiple mediators participating in the cardioprotective effects of ACEi in hypertension. ..
- Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast MilkLynn Puddington; Fiscal Year: 2010..As breast milk is enriched with monocytes/macrophages and HCMV-specific antibodies, it is possible that these maternal antibodies can influence postnatal ..
- Genomic adaptation to HIV infection of the CNS in opioid-abusersRajnish S Dave; Fiscal Year: 2012..Knowledge thus gained will help us to advance towards our long-term objective to develop RNA interference based therapies to treat HIV infection and counteract the deleterious effects of opioid-abuse. ..
- NOX1 and NOX2 as Therapeutic Targets in InfluenzaJOHN DAVID LAMBETH; Fiscal Year: 2013..transport, apoptosis of alveolar epithelial cells, an infiltration/destruction of lung tissue by neutrophils and monocytes. Currently, effective treatments to prevent lung damage do not exist...
- MIF AND THE HOST RESPONSE TO INFECTIONRICHARD J BUCALA; Fiscal Year: 2013..We will characterize the MIF-dependent responses of human monocytes and alveolar epithelial cells stimulated by TLR ligands that are representative of diverse microbial pathogens...
- DHA attenuates Inflammatory Responses Through Altering RAGE SignalingLYNETTE KAY ROGERS; Fiscal Year: 2013..sRAGE can enhance chemotaxis and promote maturation and differentiation of monocytes. This aim will investigate the mechanisms by which DHA decreases sRAGE levels in the context of hyperoxia ..
- Characterization of IL36, a novel cytokineAlbert Zlotnik; Fiscal Year: 2012..We identified many genes that exhibit strong expression in T, B cells, monocytes, or dendritic cells, including 92 uncharacterized genes that encode either transmembrane or secreted proteins...
- MicroRNA Regulation of Macrophage Polarization in Muscle RegenerationPaula K Shireman; Fiscal Year: 2013....
- SCHISTOSOME EGG INDUCED TH2 RESPONSESEdward J Pearce; Fiscal Year: 2013..We will ask whether the primary role of antibody is (in the form of immune complexes) to bind to Fc?RIIB on monocytes/macrophages and thereby inhibit inflammation during chronic schistosomiasis...
- Nanomedicine and NeuroAIDSHoward E Gendelman; Fiscal Year: 2013..Novel strategies are sought for improved ART delivery to mononuclear phagocytes (MP: monocytes, perivascular and tissue macrophages and microglia) to bring drugs to tissue viral reservoirs...
- Pulmonary Defenses Against Intracellular InfectionShawn J Skerrett; Fiscal Year: 2013..This aim will determine the ligand sensitivity of the NLRC4 inflammasome of human AM in comparison with monocytes and murine AM, determine if Lp induces or suppresses inflammasome activation in AM, and determine if stimulation ..
- Macrophage-based Human Gene Therapy for Hereditary PAPBruce C Trapnell; Fiscal Year: 2012..this proposal is that ex-vivo lentiviral vector-mediated restoration of functional GM-R expression in autologous monocytes or G-CSF-mobilized CD34+ cells followed by intrapulmonary administration into non-myeloablated recipients will ..
- Inducible Macrophage Specific Gene Expression in DiseasesJEANINE M D apos ARMIENTO; Fiscal Year: 2010..We will also examine the consequences of the absence of macrophage tissue inhibitor of metalloproteinases-3 in lung injury. ..
- Human cytomegalovirus entry into epithelial and endothelial cellsDavid C Johnson; Fiscal Year: 2013..Our studies will provide a better picture of how HCMV gains entry into biologically relevant epithelial and endothelial cells to facilitate the design of better anti-HCMV drugs and vaccines. ..
- Anthrax Toxins Impair Phagocyte Actin-based MotilityFrederick Southwick; Fiscal Year: 2010....
- Cyclic AMP, Cytokine Modulation and Alcoholic Liver DiseaseCraig J McClain; Fiscal Year: 2013..Document increased PDE4B expression/activity and decreased cAMP in peripheral blood monocytes from patients with alcoholic hepatitis (AH) and alcoholic cirrhosis, and evaluate whether in vitro incubation of ..
- Over-Expression of microRNA-126 in Macrophages for Treatment of AtherosclerosisSuzette Laing; Fiscal Year: 2013..This research proposal supports training necessary for the applicant's career goal to become a dentist-scientist studying translational research in regenerative dentistry. ..
- MNEI/SerpinB1: A modulator of innate pulmonary defenseEILEEN REMOLD-O'DONNELL; Fiscal Year: 2010..Indeed, mnei, the central molecule under study in the project, is a candidate therapeutic for inflammatory lung disease. ..
- Lipid glyceryl ester homeostasis in macrophages and perturbation by environmentalMatthew K Ross; Fiscal Year: 2012..the metabolism of 2AG (endocannabinoid) and PGE2-G (prostaglandin E2 glyceryl ester) in human blood-derived monocytes/macrophages and the THP-1 cell line...
- Interventions Against the Molecular Etiology of BMPR2-induced PAHJames D West; Fiscal Year: 2013..Aberrant glucocorticoid receptor signaling leads to increased vascular adhesion and permeability by monocytes, and this in combination with increased ROS may drive recruitment of monocytes and alternative (M2) macrophage ..
- Cellular interactions in asthmaCHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012..The particular cell types of interest will be mast cells, basophils, eosinophils, neutrophils, macrophages, monocytes, dendritic cells, T cells, and B cells...
- In vitro Type Two Diabetes Mellitus Tissue Model to Investigate Insulin ResistancKELLY ANNE BURKE; Fiscal Year: 2013..Aim 2 will add complexity to the model by incorporating human fibroblasts and monocytes, which may activate to M1 macrophages to create a pro-inflammatory environment like that found in obese adipose ..
- TNF-Mediated Tumor Promotion: The Role of Vascular LeukocytesPampee P Young; Fiscal Year: 2011..data suggest that TNF results in a dose-dependent upregulation of endothelial-specific markers in cultured monocytes. This effect was dependent on TNF receptors as cells isolated from mice lacking TNF receptors displayed ..
- COCHLEAR MACROPHAGES AND EPITHELIAL REPAIRKeiko Hirose; Fiscal Year: 2013..demonstrated that hair cell injury evokes a strong, rapid recruitment of professional phagocytes in the form of monocytes and macrophages into the mouse cochlea...
- Mechanisms mediating hematopoietic stem and progenitor cell traffickingPaul S Frenette; Fiscal Year: 2013..Further, our preliminary studies suggest that BM monocytes / macrophages (MO/MV) exert the opposite effect, enhancing the expression of HSC retention signals...
- Role of AIB1 in malignant progressionAnna Tate Riegel; Fiscal Year: 2013..We will establish the conditions in which endothelial cells co cultured with epithelium, fibroblasts and monocytes, are influenced by changes in AIB1 expression...
- TOLLIP and Tuberculosis ImmunopathogenesisJAVEED ALI SHAH; Fiscal Year: 2013..We hypothesized that TOLLIP and its common variants negatively regulate TLR signaling in human monocytes and are associated with susceptibility to tuberculosis...
- Estrogen, Aging and Vascular InflammationAnne A Knowlton; Fiscal Year: 2013..Although the work focuses on estrogen and EETs, it will provide new insights and potentially new therapies (sEH inhibitors) vascular disease, which can help both male and female veterans. ..
- CTRIP: Molecular phenotypes of rapidly progressive idiopathic pulmonary fibrosisGalen B Toews; Fiscal Year: 2010....
- Purinergic Regulation of Bone MetabolismBruce Neil Cronstein; Fiscal Year: 2013..A1 receptors regulate the stimulated formation of multinucleated giant cells by cultured human peripheral blood monocytes and therefore determined whether adenosine A1 receptors also regulated formation of osteoclasts, a related form ..
- Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory DiseaseJAMES CHRISTOPHER BONNER; Fiscal Year: 2010..This alarming observation raises the possibility that carbon nanotubes could pose a serious threat to human health and the environment. ..
- Lung and bone marrow crosstalk during a respiratory infectionCAROLINA B LOPEZ; Fiscal Year: 2010..Information regarding the contribution of monocytes, granulocytes, and other non-antigen specific cells recruited from the BM for lung immunity is also lacking...
- IMMUNOLOGICAL ASPECTS OF HEMORRHAGEIrshad H Chaudry; Fiscal Year: 2010..in Kupffer cells, alveolar MO, PMO, SMO, splenic dendritic cells (DC) and splenic T cells, peripheral blood monocytes and T cells and correlate those changes with their effector responses (MO and DC: MO/DC antigen presentation and ..
- HIV and CD16+ monocytes as cellular reservoir &HIV/pulmonary hypertensionSharilyn Almodovar; Fiscal Year: 2013..The applicant and others have shown that classic CD14+ monocytes do not carry HIV during suppressive HAART and CD16+ pro- inflammatory monocytes in peripheral blood harbor viral ..
- Novel GPCR Kinase Interactions in Macrophages and Role in ArthritisNarayanan Parameswaran; Fiscal Year: 2009b>Monocytes/macrophages are crucial cell types in inflammatory processes in many diseases including musculoskeletal diseases...
- Bone marrow monocyte output and virus import into the CNS in acute SIV infectionMichael McChesney; Fiscal Year: 2009DESCRIPTION (provided by applicant): Monocytes and macrophages play a central role in the pathogenesis of human immunodeficiency virus (HIV)-associated dementia...
- Adrenergic Control of Stem Cell Lineage Commitment in SepsisKUZHALI MUTHUMALAIAPPAN; Fiscal Year: 2009..Decrease in hyper-responsive or an increase in hypo-responsive monocytes may in part be the reason behind injury induced immune suppression...
- Genistein for the Prevention and Treatment of Diabetic Vascular InflammationDongmin Liu; Fiscal Year: 2009..IL-8) in human aortic ECs (HAECs), two chemokines that are the key factors in the firm adhesion of monocytes to activated ECs. Our recent studies found that genistein is an activator of the cAMP signaling system in ECs...
- REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTESNigel Mackman; Fiscal Year: 2009..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
- RESISTANCE OF OPPORTUNISTIC INFECTION BY MYCOBACTERIAD Blanchard; Fiscal Year: 1992..and interleukin 2 (IL 2)-activated killer (LAK) cells from nonimmune donors can lyse autologous MAI-infected monocytes, thus limiting the intracellular growth of this organism...
- ALVEOLAR MACROPHAGES AND DEFENSE OF THE LUNG IN AIDSPaul Luciw; Fiscal Year: 1993..In infected individuals, virus is found in peripheral blood monocytes/macrophage (PBMM), alveolar macrophage (AM), as well as in monocyte-related cells in the bone marrow, brain, and ..
- MONOCYTE RECRUITMENT IN PLEUROPULMONARY TB IN AIDSVeena Antony; Fiscal Year: 2005..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
- METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATIONRUDOLFS ZALUPS; Fiscal Year: 2006..Activation is the acute phase response and respiratory burst undergone by monocytes (and other leukocytes) as a response to extracellular events and signals...
- MONOCYTE CHEMOATTRACTANT PROTEIN 1 IN THE CORPUS LUTEUMPAUL KEYES; Fiscal Year: 1999..The biological signals that are responsible for the massive recruitment of monocytes/macrophages into the corpus luteum at the end of the cycle, and the mechanisms which prevent their recruitment ..
- Monocyte P311 Expression Level as Predictor of Hypertension in MiceLucia Schuger; Fiscal Year: 2010..muscle [11, 24], in wound myofibroblasts  and their precursors, the pre-myofibroblasts ;and in blood monocytes (research plan, figures 5 and 7)...
- Monocyte Modulation in LAgPSUZANNE BARBOUR; Fiscal Year: 2005..Several lines of evidence suggest that LAgP monocytes exhibit a unique phenotype...
- LPS and Monocyte Activation in HIV NeuropathogenesisDana Gabuzda; Fiscal Year: 2009..The studies will also provide information that could help to identify new potential therapeutic strategies for HIV/AIDS. ..
- Monocyte Pathogenesis: Regulation of NADPH OxidaseMARTHA CATHCART; Fiscal Year: 2007The production of superoxide anion (02-) by activated monocytes and neutrophils is an essential element of host defense and inflammation. 02- is generated via the enzyme complex, NADPH oxidase...