reticulum

Summary

Summary: The second stomach of ruminants. It lies almost in the midline in the front of the abdomen, in contact with the liver and diaphragm and communicates freely with the RUMEN via the ruminoreticular orifice. The lining of the reticulum is raised into folds forming a honeycomb pattern over the surface. (From Concise Veterinary Dictionary, 1988)

Top Publications

  1. pmc Morphometric and immunohistochemical study of the reticulum of red deer during prenatal development
    A J Franco
    Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Extremadura, Caceres, Spain
    J Anat 205:277-89. 2004
  2. doi Ontogenesis of the reticulum with special reference to neuroendocrine and glial cells: a comparative analysis of the Merino sheep and Iberian red deer
    A Franco
    Department of Veterinary Anatomy, University of Extremadura, 10071, Caceres, Spain
    Anat Histol Embryol 41:362-73. 2012
  3. pmc Intrinsic innervation patterns of the smooth muscle in the rumen and reticulum of lambs
    Helga Pfannkuche
    Veterinär Physiologisches Institut, Veterinärmedizinische Fakultät, Universitat Leipzig, Germany
    J Anat 204:293-9. 2004
  4. ncbi Histomorphometric and immunohistochemical study of the goat reticulum during prenatal development
    A Garcia
    Department of Veterinary Histology, Faculty of Veterinary Medicine, University of Extremadura, Caceres, Spain
    Histol Histopathol 28:1369-81. 2013
  5. ncbi Radiographic and ultrasonographic findings in three cows with reticulo-omasal obstruction due to a foreign body
    U Braun
    Klinik für Wiederkäuer und Pferdemedizin der Universität Zürich, Switzerland
    Vet Rec 150:580-1. 2002
  6. ncbi Ultrasonographic evaluation of reticular motility in 144 cattle with vagal indigestion
    U Braun
    Department of Farm Animals, University of Zurich, Zurich, Switzerland
    Vet Rec 164:11-3. 2009
  7. ncbi Ultrasonographic evaluation of reticular motility during rest, eating, rumination and stress in 30 healthy cows
    U Braun
    Department of Farm Animals, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Vet Rec 163:571-4. 2008
  8. ncbi Ultrasonography of the reticulum in cows
    U Braun
    Clinic of Veterinary Internal Medicine, University of Zurich, Switzerland
    Am J Vet Res 55:325-32. 1994
  9. ncbi Ultrasonographic findings in cows with traumatic reticuloperitonitis
    U Braun
    Clinic of Veterinary Internal Medicine, University of Zurich, Switzerland
    Vet Rec 133:416-22. 1993
  10. doi Ultrasonographic assessment of the reticular motility in cows after administration of different doses of metoclopramide and neostigmine
    Sabry A El-Khodery
    Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
    Vet Res Commun 32:473-80. 2008

Detail Information

Publications340 found, 100 shown here

  1. pmc Morphometric and immunohistochemical study of the reticulum of red deer during prenatal development
    A J Franco
    Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Extremadura, Caceres, Spain
    J Anat 205:277-89. 2004
    ....
  2. doi Ontogenesis of the reticulum with special reference to neuroendocrine and glial cells: a comparative analysis of the Merino sheep and Iberian red deer
    A Franco
    Department of Veterinary Anatomy, University of Extremadura, 10071, Caceres, Spain
    Anat Histol Embryol 41:362-73. 2012
    The present study was designed to compare the differences in the ontogenesis of the reticulum in sheep (domestic ruminant) and deer (wild ruminant)...
  3. pmc Intrinsic innervation patterns of the smooth muscle in the rumen and reticulum of lambs
    Helga Pfannkuche
    Veterinär Physiologisches Institut, Veterinärmedizinische Fakultät, Universitat Leipzig, Germany
    J Anat 204:293-9. 2004
    The rumen and reticulum of sheep serve as a fermentation chamber. Both compartments exhibit specific motility patterns...
  4. ncbi Histomorphometric and immunohistochemical study of the goat reticulum during prenatal development
    A Garcia
    Department of Veterinary Histology, Faculty of Veterinary Medicine, University of Extremadura, Caceres, Spain
    Histol Histopathol 28:1369-81. 2013
    This study sought to describe the morphological changes taking place in the goat reticulum during prenatal development, using histomorphometric and immunohistochemical techniques...
  5. ncbi Radiographic and ultrasonographic findings in three cows with reticulo-omasal obstruction due to a foreign body
    U Braun
    Klinik für Wiederkäuer und Pferdemedizin der Universität Zürich, Switzerland
    Vet Rec 150:580-1. 2002
  6. ncbi Ultrasonographic evaluation of reticular motility in 144 cattle with vagal indigestion
    U Braun
    Department of Farm Animals, University of Zurich, Zurich, Switzerland
    Vet Rec 164:11-3. 2009
    ..05) than those with distal functional stenosis (3.6 [2.16]). The position, contour and size of the reticulum, the amplitude and speed of the contractions and the area surrounding the reticulum did not differ significantly ..
  7. ncbi Ultrasonographic evaluation of reticular motility during rest, eating, rumination and stress in 30 healthy cows
    U Braun
    Department of Farm Animals, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Vet Rec 163:571-4. 2008
    A 3.5 MHz linear transducer was used to assess the motility of the reticulum in 30 healthy, standing, non-sedated cows while they were at rest, eating, ruminating and under stress...
  8. ncbi Ultrasonography of the reticulum in cows
    U Braun
    Clinic of Veterinary Internal Medicine, University of Zurich, Switzerland
    Am J Vet Res 55:325-32. 1994
    The reticulum and adjacent organs were examined ultrasonographically in 51 cows by use of a 3.5-MHz linear transducer applied to the ventral aspect of the thorax over the sixth and seventh intercostal spaces...
  9. ncbi Ultrasonographic findings in cows with traumatic reticuloperitonitis
    U Braun
    Clinic of Veterinary Internal Medicine, University of Zurich, Switzerland
    Vet Rec 133:416-22. 1993
    The morphological changes in the region of the reticulum were examined ultrasonographically in 26 cows with traumatic reticuloperitonitis, and a radiograph of the reticulum was also taken...
  10. doi Ultrasonographic assessment of the reticular motility in cows after administration of different doses of metoclopramide and neostigmine
    Sabry A El-Khodery
    Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
    Vet Res Commun 32:473-80. 2008
    ..The findings of this study in healthy animals may not be extrapolatable to findings in cattle with reticuloruminal hypomotility...
  11. pmc Ultrasonography of the reticulum in 30 healthy Saanen goats
    Ueli Braun
    Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Acta Vet Scand 53:19. 2011
    The reticulum plays a crucial role in the ruminant digestive tract because the primary cycle of rumen motility always starts with a reticular contraction...
  12. ncbi Ultrasonographic findings in five cows before and after treatment of reticular abscesses
    U Braun
    Clinic of Veterinary Internal Medicine, University of Zurich, Switzerland
    Vet Rec 142:184-9. 1998
    ..radiographic examination, a tentative diagnosis of reticular abscess was made in four of the cows, because the reticulum was displaced from the peritoneum or because there was an extensive gas-fluid interface in the reticular region...
  13. ncbi Tremorgenic mycotoxins increase gastric smooth muscle activity of sheep reticulum and rumen in vitro
    L Wang
    Department of Biological Sciences, The University of Waikato, PB 3105, Hamilton, New Zealand
    Res Vet Sci 74:93-100. 2003
    b>Reticulum and rumen strips (consisting of both muscle layers and the myenteric plexus) were superfused with Tyrode Ringer and their contractions recorded isometrically...
  14. ncbi New types of foreign bodies and the effect of magnets in traumatic reticulitis in cows
    T Cramers
    Royal Veterinary and Agricultural University, DK 1870 Frederiksberg C, Denmark
    Vet Rec 157:287-9. 2005
  15. ncbi Distribution of rhodanese in tissues of goat (Capra hircus)
    Saeed Nazifi
    Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
    Comp Biochem Physiol B Biochem Mol Biol 134:515-8. 2003
    ..05). The highest activity of rhodanese was in epithelium of rumen, followed by epithelia of reticulum and omasum and liver. No significant difference was observed when tissues of male and female goats were compared...
  16. ncbi Effects of atropine, scopolamine and xylazine on the placement of an orally administered magnet in cows
    U Braun
    Department of Farm Animals, University of Zurich, Switzerland
    Vet Rec 152:258-60. 2003
    ..scopolamine or xylazine to cows before the administration of a magnet orally would help to position it in the reticulum. The transit time of the magnet through the oesophagus was also measured...
  17. ncbi Effects of small ruminal boluses used for electronic identification of lambs on the growth and development of the reticulorumen
    D Garin
    Group de Recerca en Remugants, Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Anim Sci 81:879-84. 2003
    ..reticulorumen used to evaluate papillae size, number of dead cells, and degree of keratinization of both the reticulum wall and the rumen wall epithelia. Weight at weaning (13...
  18. ncbi [Radiographic findings in 4 cows with traumatic reticuloperitonitis caused by a nonmagnetic copper wire]
    U Braun
    Departement für Nutztiere, Universitat Zurich
    Schweiz Arch Tierheilkd 145:169-75. 2003
    ..The reticulum of all cows was then examined ultrasonographically and radiographically...
  19. ncbi Unusual traumatic reticuloperitonitis in a cow
    Neil W Frame
    Vet Rec 154:379. 2004
  20. ncbi Unusual traumatic reticuloperitonitis in a cow
    Den Leonard
    Vet Rec 154:344. 2004
  21. ncbi Immunohistochemical evaluation of the muscularis mucosae in the ruminant forestomach
    N Kitamura
    Department of Veterinary Anatomy, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Anat Histol Embryol 32:175-8. 2003
    ..The specimens were collected from the rumen, reticulum and omasum of cattle, water buffalo, sheep, goat, Barbary sheep, Japanese serow, sika deer and mouse deer...
  22. ncbi Post surgical development of inflammatory adhesions and reticular function in cows suffering from traumatic reticuloperitonitis
    K Herzog
    Clinic for Cattle, School of Veterinary Medicine Hannover, Germany
    Dtsch Tierarztl Wochenschr 111:57-62. 2004
    Inflammatory adhesions between reticulum and ventral abdomen in patients suffering traumatic reticuloperitonitis (TRP) may induce a massive inhibition of reticular contractions and thereby an impairment of the separation process of ..
  23. ncbi Retention of different sizes of electronic identification boluses in the forestomachs of sheep
    J J Ghirardi
    Grup de Recerca en Remugants, Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Anim Sci 84:2865-72. 2006
    ..For safe and efficient retention of electronic identification boluses in sheep, boluses of small volume and diameter (e.g., < 15 mm) with specific gravity and weight greater than 3.0 and 20 g, respectively, are recommended...
  24. ncbi Use of cardiac troponin kits for the qualitative determination of myocardial cell damage due to traumatic reticuloperitonitis in cattle
    V Gunes
    Department of Veterinary Internal Medicine, School of Veterinary Medicine, University of Erciyes, Kayseri, Turkey
    Vet Rec 162:514-7. 2008
    ..The cTn-I and cTn-T kits both gave positive results in three of the cattle with trp and the quantitative measurement of cTn-I was positive in 11 of the trp cases. Both tests were negative in the healthy cattle...
  25. ncbi Ultrasonographic evaluation of reticular motility in cows after administration of atropine, scopolamine and xylazine
    U Braun
    Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, University of Zurich, Switzerland
    J Vet Med A Physiol Pathol Clin Med 49:299-302. 2002
    ..This study demonstrated that administration of atropine, scopolamine and xylazine results in reticular atony. Whether this has clinical relevance requires further investigation...
  26. ncbi Comparison of blood serum proteins in water buffaloes with traumatic reticuloperitonitis and sequellae
    Mostafa A Saleh
    Biochemistry Unit, Regional Animal Health Research Laboratory, Animal Health Research Institute, El Kharga, El Wadi El Gadid 725211, Egypt
    Res Vet Sci 85:208-13. 2008
    ..In conclusion, the concentrations and electrophoretic patterns of serum proteins in buffaloes differ according to the anatomical location of the foreign body and the associated pathological lesions...
  27. ncbi [Dynamics of rumenoenteral transport of progesterone in sheep in chronic experiment]
    M F Borisenkov
    Ross Fiziol Zh Im I M Sechenova 92:374-8. 2006
    ..001). The data obtained confirm the assumption that forestomach of ruminants participates in removing of progesterone from internal environment to enteral one and that carbohydrate polymers facilitate this process...
  28. doi Renal amyloidosis in cattle with inflammatory diseases
    O M Elitok
    Food Hygiene and Control Division, Agriculture Researching Institute, Afyonkarahisar, Turkey
    J Vet Intern Med 22:450-5. 2008
    ..The association of inflammatory diseases such as traumatic reticuloperitonitis (TRP), mastitis, metritis, and pododermatitis with renal amyloidosis in cattle is poorly described...
  29. ncbi Bypassing the rumen in dairy ewes: the reticular groove reflex vs. calcium soap of olive fatty acids
    C Dobarganes García
    Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, 41012 Sevilla, Spain
    J Dairy Sci 88:741-7. 2005
    ....
  30. ncbi Splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers
    N B Kristensen
    Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Denmark
    J Anim Sci 82:2033-42. 2004
    ..When PDV "second-pass" uptake of arterial nutrients is accounted for, PDV fluxes of VFA, lactate, and 3-hydroxybutyrate represent VFA production in the gastrointestinal tract and thereby VFA availability to the ruminant animal...
  31. ncbi The sensitivities and specificities of total plasma protein and plasma fibrinogen for the diagnosis of traumatic reticuloperitonitis in cattle
    Seyed Reza Jafarzadeh
    Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, P O Box 14155 6453, Tehran, Iran
    Prev Vet Med 65:1-7. 2004
    ..78g/dl and 691mg/dl cut-off points, respectively. Acceptable accuracy (98 or 86% specificity with 62 or 88% sensitivity, respectively) was obtained with serial interpretation of the tests...
  32. ncbi Radiographic findings before and after oral administration of a magnet in cows with traumatic reticuloperitonitis
    Ueli Braun
    Department of Farm Animals, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Am J Vet Res 64:115-20. 2003
    ..To evaluate by use of radiography the efficacy of oral administration of magnets in the treatment of traumatic reticuloperitonitis in cows...
  33. ncbi Ultrastructural pathology of glial brain tumors revisited: a review
    P P Liberski
    Department of Oncology, Medical Academy Lodz, Poland
    Ultrastruct Pathol 21:1-31. 1997
    ..of neoplastic astrocytes, are characterized by nuclei that seem to be more indented, cisterns of the endoplastic reticulum may be distended, and intranuclear pseudoinclusions are frequently observed...
  34. ncbi [A study of the expression of sarcoplasmic reticulum calcium ATP-ase gene in the left ventricle of the sheep's fetus submitted to chronic increased afterload in utero]
    N Bonnet
    , Centre chirurgical Maria-Lannelongue, Le Plessis-Robinson
    Arch Mal Coeur Vaiss 90:699-705. 1997
    The messenger RNA of the cardiac sarcoplasmic reticulum ATP-ase (SERCA-2a) increases in the left ventricle (LV) during ontogenic development but decreases in hypertrophy induced by increased afterload...
  35. pmc Activation of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by analogues of sulmazole
    S J McGarry
    Department of Cardiac Medicine, National Heart and Lung Institute, University of London
    Br J Pharmacol 111:1212-20. 1994
    1. The effect of sulmazole and several structurally related analogues on cardiac sarcoplasmic reticulum (SR) Ca(2+)-release channel gating and on [3H]-ryanodine binding to isolated SR membrane vesicles has been investigated. 2...
  36. ncbi [Ionic perturbations produced by a non-laminar flow in vascular smooth muscle cells in culture. Protection by cicletanine via a cyclo-oxygenase metabolite]
    C Rosati
    INSERM U7/CNRS UA 318, , Paris
    Arch Mal Coeur Vaiss 82:41-4. 1989
    ..Sodium nitroprusside, a compound able to stimulate calcium entry in the sarcoplasmic reticulum via cyclic GMP, was also able to protect vascular cells (although it acted at higher concentrations than ..
  37. ncbi Roles of protein kinase C on the mechanical activity of vascular smooth muscles
    T Itoh
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Am J Hypertens 3:216S-219S. 1990
    ..contraction was not related to activation of either the voltage-dependent Ca channel or the sarcoplasmic reticulum, and did not occur in the case of Ca-independent contraction in skinned muscle tissues...
  38. ncbi Oxidative injury induces influx-dependent changes in intracellular calcium homeostasis
    J D Swann
    Department of Pathology, School of Medicine, University of Maryland, Baltimore 21201
    Toxicol Pathol 19:128-37. 1991
    ..a progression of changes characteristic of lethal cell injury, beginning with dilatation of the endoplasmic reticulum, detachment of ribosomes, condensation of mitochondria, and chromatin clumping and terminating with ..
  39. pmc Inhibitory effects of nordihydroguaiaretic acid on ETA-receptor-mediated contractions to endothelin-1 in rat trachea
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 111:561-9. 1994
    ..5. Like NDGA, the sarcoplasmic reticulum Ca(2+)-ATPase inhibitors cyclopiazonic acid and thapsigargin inhibited contractions to ET-1, but not carbachol ..
  40. ncbi Angiotensin II stimulation of vascular smooth muscle cells. Secondary signalling mechanisms
    K K Griendling
    Department of Medicine, Emory University, Atlanta, GA 30322
    Am J Hypertens 2:659-65. 1989
    ..IP3 is responsible for mobilizing calcium from endoplasmic reticulum whereas DG activates protein kinase C and ultimately Na+/H+ exchange, leading to intracellular alkalinization...
  41. ncbi Subchronic toxicity of atorvastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor, in beagle dogs
    K M Walsh
    Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Toxicol Pathol 24:468-76. 1996
    ..seen at > or = 150 mg/kg and included hepatocellular eosinophilia related to increased smooth endoplasmic reticulum and cholangiohepatitis and cholecystitis at 150 mg/kg in the 2-wk toxicity study; hepatocellular degeneration, ..
  42. ncbi Aggressive small cell tumor of the skull base
    M Arnesen
    Department of Pathology, Abbott Northwestern Hospital, Minneapolis, Minnesota 55407
    Ultrastruct Pathol 18:191-7. 1994
    ..Electron microscopy revealed epithelial cells with abundant rough endoplasmic reticulum and electron-dense membrane-bound endocrine granules, some undergoing misplaced exocytosis...
  43. ncbi Liver tumor promoting effects of fenbendazole in rats
    T Shoda
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Toxicol Pathol 27:553-62. 1999
    ..Periportal hepatocellular hypertrophy, characterized by a marked increase in smooth endoplasmic reticulum, was observed in the groups given > or =600 ppm with or without DEN initiation...
  44. pmc The superficial buffer barrier in venous smooth muscle: sarcoplasmic reticulum refilling and unloading
    Q Chen
    University of Miami School of Medicine, Department of Molecular and Cellular Pharmacology, FL 33101
    Br J Pharmacol 109:336-43. 1993
    1. The interaction of Ca2+ transport in the plasmalemma and the sarcoplasmic reticulum (SR) was investigated in smooth muscle of the rabbit inferior vena cava...
  45. pmc Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform
    Y Amrani
    INSERM U 425, , Illkirch, France
    Br J Pharmacol 115:1204-10. 1995
    1. The contribution of sarco-endoplasmic reticulum Ca(2+)-ATPases (SERCA)-regulated Ca2+ stores to the increase in intracellular free calcium ([Ca2+]i) induced by bradykinin (BK) was investigated in fura-2 loaded human tracheal smooth ..
  46. ncbi Bile acids in the assessment of hepatocellular function
    M B Thompson
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:62-71. 1996
    ..Synthesis of bile acids in hepatocytes involves steps in endoplasmic reticulum, cytosol, mitochondria, and peroxisomes...
  47. ncbi 2,2,2-Trifluoroethanol toxicity in aged rats
    J C Kim
    Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201
    Toxicol Pathol 16:35-45. 1988
    ..studies of liver from TFE-treated rats revealed rather diffuse loss of glycogen, fragmentation of endoplasmic reticulum, mineralization of mitochondria, and loss of other organelles within the hepatocytes versus saline-treated aged ..
  48. ncbi [The excitation-contraction coupling of the vascular smooth muscle cells]
    E Honore
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Valbonne
    Arch Mal Coeur Vaiss 84:9-13. 1991
    ..Only the L calcium channels are sensitive to dihydropyridines. The liberation of Ca2+ from the sarcoplasmic reticulum which is the intracellular reservoir of calcium can be controlled by two different mechanisms: a direct ..
  49. ncbi Expression and secretion of beta-galactosidase in Saccharomyces cerevisiae using the signal sequences of GgpI, the major yeast glycosylphosphatidylinositol-containing protein
    R Pignatelli
    Dipartimento di Fisiologia e Biochimica Generali, , Italy
    Biotechnol Appl Biochem 27:81-8. 1998
    ..in secretion by fusion to the lacZ gene of Escherichia coli resulting in the synthesis of the endoplasmic reticulum-targeted 1-22- and 1-68-GgpIp/beta-gal hybrids. A cytoplasmic form was also examined...
  50. ncbi Intranodal myofibroblastoma: report of a case
    B P Eyden
    Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom
    Ultrastruct Pathol 20:79-88. 1996
    ..The cytoplasm contained moderate numbers of rough endoplasmic reticulum cisternae and some smooth-muscle type myofilaments...
  51. ncbi Immunolocalization of tripeptidyl peptidase II, a cholecystokinin-inactivating enzyme, in rat brain
    P Facchinetti
    Laboratoire de Physiologie, , Paris, France
    Neuroscience 88:1225-40. 1999
    ..It was mainly associated with the cytoplasm of neuronal somata and dendrites, often in the vicinity of reticulum cisternae, Golgi apparatus or vesicles, and with the inner side of the dendritic plasma membrane...
  52. ncbi Myofibroblastoma of breast: evidence favoring smooth-muscle rather than myofibroblastic differentiation
    B P Eyden
    Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, UK
    Ultrastruct Pathol 23:249-57. 1999
    ..Tumor cells contained rough endoplasmic reticulum, bundles of myofilaments with focal densities, intermediate filaments, attachment plaques alternating with ..
  53. ncbi Isolated hepatocytes of rainbow trout (Oncorhynchus mykiss) as a tool to discriminate between differently contaminated small river systems
    M Strmac
    Aquatic Toxicology and Ecology Group, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D-69120, Heidelberg, Germany
    Toxicol In Vitro 14:361-77. 2000
    ..increase of heterochromatin, heterogeneity of mitochondria, vesiculation of cisternae of the rough endoplasmic reticulum, as well as proliferation of the smooth endoplasmic reticulum...
  54. pmc A sorting signal for the basolateral delivery of the vesicular stomatitis virus (VSV) G protein lies in its luminal domain: analysis of the targeting of VSV G-influenza hemagglutinin chimeras
    T Compton
    Department of Cell Biology, New York University Medical Center, New York 10016
    Proc Natl Acad Sci U S A 86:4112-6. 1989
    ..Both chimeras were transported from the endoplasmic reticulum to the Golgi apparatus and from there to the cell surface with the same rapid kinetics as the intact G protein...
  55. ncbi The pathways of cell death: oncosis, apoptosis, and necrosis
    B F Trump
    Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
    Toxicol Pathol 25:82-8. 1997
    ..In this common reaction, the earliest changes involve cytoplasmic blebbing, dilatation of the endoplasmic reticulum (ER), swelling of the cytosol, normal or condensed mitochondria, and chromatin clumping in the nucleus...
  56. ncbi Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:325-33. 1999
    ..age had distorted nuclei with condensed matrix and abundant secretory granules associated with rough endoplasmic reticulum and Golgi apparatus...
  57. ncbi Morphological changes in the pituitary gland of dogs chronically exposed to exogenous growth hormone
    P Laroque
    Merck Sharp and Dohme Chibret Laboratories, Department of Safety Assessment, Riom, France
    Toxicol Pathol 26:201-6. 1998
    ..gland of high-dose demonstrated, in both sexes, pituitary cells with variably dilated rough endoplasmic reticulum and decreased numbers of secretory granules; some of these cells reacted positively to GH immunostaining...
  58. ncbi Cat scratch disease and acquired immunodeficiency disease: diagnosis by transmission electron microscopy
    J G Guccion
    Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Washington, DC, USA
    Ultrastruct Pathol 20:195-202. 1996
    ..biopsy specimen revealed effacement of the lymph node architecture by a diffuse infiltrate of large, atypical reticulum cells, loose, patchy granulomatous inflammation, diffuse hyaline fibrosis, diffusely proliferated blood vessels, ..
  59. pmc Heparin-insensitive calcium release from intracellular stores triggered by the recombinant human parathyroid hormone receptor
    K Seuwen
    Preclinical Research, Sandoz Pharma Ltd, Basel, Switzerland
    Br J Pharmacol 114:1613-20. 1995
    ..medium but was absent in cells pretreated with thapsigargin, an inhibitor of the calcium pump of the endoplasmic reticulum (ER). hPTH-(1-38) did not accelerate Mn(2+)-influx through the plasma membrane...
  60. ncbi 2,2,2-Trifluoroethanol toxicity in hamsters (Mesocricetus auratus)
    J C Kim
    Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201
    Toxicol Pathol 15:417-24. 1987
    ..studies of acutely treated animals indicate that fat vacuoles formed within the hepatic endoplasmic reticulum characterized by lamellar bodies forming multiple myelin figures within the fat vacuoles...
  61. ncbi Impaired recovery of vascular smooth muscle intracellular calcium following agonist stimulation in insulin resistant (Zucker obese) rats
    M A Abel
    Department of Physiology Program, University of Tennessee, Knoxville 37996-1900
    Am J Hypertens 6:500-4. 1993
    ..02). Since we have recently shown insulin to increase AII-releasable Ca2+ stores in sarcoplasmic reticulum, this increase in peak [Ca2+]i response to AII in ZL may reflect relative VSMC insulin resistance in ZO...
  62. pmc Cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca(2+)-pump, reduces Ca(2+)-dependent K+ currents in guinea-pig smooth muscle cells
    M Suzuki
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    Br J Pharmacol 107:134-40. 1992
    1. Effects of cyclopiazonic acid (CPA), a specific inhibitor of the Ca(2+)-ATPase in sarcoplasmic reticulum (SR), on membrane ionic currents were examined in single smooth muscle cells freshly isolated from ileal longitudinal strips and ..
  63. pmc A screen for dominant negative mutants of SEC18 reveals a role for the AAA protein consensus sequence in ATP hydrolysis
    G J Steel
    The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Mol Biol Cell 11:1345-56. 2000
    An evolutionarily ancient mechanism is used for intracellular membrane fusion events ranging from endoplasmic reticulum-Golgi traffic in yeast to synaptic vesicle exocytosis in the human brain...
  64. ncbi Pathology of perbutylated-N-butyl-1-deoxynojiromycin (an alpha-glucosidase-1 inhibitor) in Sprague-Dawley rats
    K N Khan
    Department of Product Safety Assessment, Searle Research and Development, Skokie, Illinois 60077, USA
    Toxicol Pathol 24:531-8. 1996
    ..inhibitor, is a candidate anti-HIV agent targeted against viral glycoprotein processing in host cell endoplasmic reticulum. The potential toxicity of this compound was evaluated in Sprague-Dawley rats after 4, 13, or 26 wk of oral ..
  65. ncbi Etoposide- and BMY-40481-induced sensory neuropathy in mice
    C L Bregman
    Bristol Myers Squibb Pharmaceutical Research Institute, Department of Pathology, Syracuse, New York 13221
    Toxicol Pathol 22:528-35. 1994
    ..Ultrastructurally, ganglion cell bodies had focally extensive dilation of the rough endoplasmic reticulum, mitochondrial swelling, increased numbers of phagolysosomes and prominent aggregations of microfilaments (..
  66. ncbi Localisation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the mitochondrial matrix of Trypanosoma brucei procyclics
    N Heise
    Christian de Duve Institute of Cellular Pathology ICP, and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    Z Naturforsch C 55:473-7. 2000
    ..matrix with some additional membrane-associated activity in glycosomes and possibly in the endoplasmic reticulum. It is suggested that the active metabolism of threonine and/or leucine as preferred 2-carbon source for the ..
  67. ncbi Heart failure: an update on pathophysiology
    H Drexler
    Medizinische Klinik III, University of Freiburg, Germany
    Arch Mal Coeur Vaiss 87:13-6. 1994
    ..Depressed expression of sarcoplasmatic reticulum ATPase is the hallmark of this overload phenotype...
  68. ncbi Role of endoplasmic reticulum-derived vesicles in the formation of Golgi elements in sec23 and sec18 Saccharomyces Cerevisiae mutants
    M N Morin Ganet
    , CEA Saclay, France
    Anat Rec 251:256-64. 1998
    ..degrees C) to the restrictive (37 degrees C) temperature, the secretory pathway is blocked between endoplasmic reticulum (ER) and Golgi elements...
  69. ncbi Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders
    Katalin Sas
    Department of Neurology, University of Szeged, POB 427, H 6701 Szeged, Hungary
    J Neurol Sci 257:221-39. 2007
    ..by a higher degree of reactive oxygen species production, and by diminished functions of the endoplasmic reticulum and the proteasome system, which are responsible for maintenance of the normal protein homeostasis of the cell...
  70. pmc Brefeldin A enables synthesis of active lipoprotein lipase in cld/cld and castanospermine-treated mouse brown adipocytes via translocation of Golgi components to endoplasmic reticulum
    J W Park
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 317:125-34. 1996
    ..3T3-L1 adipocytes synthesize lipoprotein lipase (LPL) which is inactive and retained in the endoplasmic reticulum (ER) [Masuno, Blanchette-Mackie, Chernick and Scow (1990) J.Biol. Chem...
  71. pmc Effects of ivermectin and midecamycin on ryanodine receptors and the Ca2+-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle
    G P Ahern
    Muscle Research Group, John Curtin School of Medical Research, PO Box 334, Canberra, ACT 2601, Australia
    J Physiol 514:313-26. 1999
    1. Ryanodine receptor (RyR) Ca2+ channels in the sarcoplasmic reticulum (SR) of skeletal muscle are regulated by the 12 kDa FK506- (or rapamycin-) binding protein (FKBP12)...
  72. pmc Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel
    S J McGarry
    Department of Cardiac Medicine, University of London
    Br J Pharmacol 114:231-7. 1995
    ..R56865 (N-[1-[4-(4-fluorophenoxy)-butyl]-4-piperidinyl]-N-methyl-2- benzothiazolamine) on cardiac sarcoplasmic reticulum (SR) Ca(2+)-release channel function was investigated...
  73. ncbi Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex
    J W Phillis
    Department of Physiology, Wayne State University School of Medicine, 5374 Scott Hall, 540 E Canfield Ave, Detroit, MI 48201 1928, USA
    Brain Res 957:12-24. 2002
    ..study evaluated the effects of immunosuppressants agents, calcineurin inhibitors and blockade of endoplasmic reticulum (ER) calcium channels on free fatty acid formation and efflux in the ischemic/reperfused (I/R) rat brain...
  74. ncbi FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum
    E N Chini
    Departments of Physiology, Biophysics, and Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 92:1361-5. 2000
    FK506 binding protein is closely associated with the sarcoplasmic reticulum ryanodine receptor-channel and can modulate its function. The ryanodine receptor is stabilized by its association with FK506 binding protein...
  75. doi Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis
    Adam K Walker
    Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria 3010, Australia
    Brain 133:105-16. 2010
    ..Endoplasmic reticulum stress leading to apoptosis was recently recognized to be an important process in the pathogenesis of sporadic ..
  76. ncbi Intracellular processes associated with vesicular transport from endoplasmic reticulum to Golgi and exocytosis: ethanol-induced changes in membrane biogenesis
    A Slomiany
    Research Center, University of Medicine and Dentistry of New Jersey, Newark 07103 2400
    Arch Biochem Biophys 310:247-55. 1994
    Membrane biogenesis, expressed in endoplasmic reticulum (ER) by formation of transport vesicles, was studied in the liver of ethanol-fed and pair-fed rats...
  77. ncbi Oligosaccharyl transferase is a constitutive component of an oligomeric protein complex from pig liver endoplasmic reticulum
    W Breuer
    Institut fur Physiologische Chemie, Bonn, Germany
    Eur J Biochem 228:689-96. 1995
    Oligosaccharyl transferase (OST), an intrinsic component of the endoplasmic reticulum membrane, catalyses the N-glycosylation of specific asparagine residues in nascent polypeptide chains...
  78. ncbi Sarcoplasmic reticulum calcium pump in cardiac and slow twitch skeletal muscle but not fast twitch skeletal muscle undergoes phosphorylation by endogenous and exogenous Ca2+/calmodulin-dependent protein kinase. Characterization of optimal conditions for c
    C Hawkins
    Department of Physiology, University of Western Ontario, London, Canada
    J Biol Chem 269:31198-206. 1994
    We have demonstrated recently that in cardiac sarcoplasmic reticulum (SR), a membrane-associated Ca2+/calmodulin-dependent protein kinase (CaM kinase) phosphorylates and activates the Ca(2+)-pumping ATPase (Ca(2+)-ATPase) in addition to ..
  79. ncbi Importance of glycosidases in mammalian glycoprotein biosynthesis
    A Herscovics
    McGill Cancer Centre, McGill University, 3655 Drummond Street, Montreal, Que, Canada
    Biochim Biophys Acta 1473:96-107. 1999
    ..Processing glycosidases also play a role in the folding of newly formed glycoproteins and in endoplasmic reticulum quality control...
  80. ncbi [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane]
    Martin Pierre Sauviat
    Laboratoire d Optique et Biosciences, INSERM U 451 CNRS UMR 7645 X ENSTA, Ecole Polytechnique, 91128 Palaiseau, France
    J Soc Biol 196:339-48. 2002
    ..and incorporates into biological membranes according to the following sequence: mitochondria > sarcoplasmic reticulum > myelin > brain microsomes > erythrocytes...
  81. ncbi [Study on endoplasmic reticulum stress and injury to basic function unit of colonic motility in rats with scald injury]
    Ying Li
    Department of Burns and Plastic Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China
    Zhonghua Shao Shang Za Zhi 25:193-6. 2009
    ....
  82. pmc Reduction of calcium inactivation of sarcoplasmic reticulum calcium release by fura-2 in voltage-clamped cut twitch fibers from frog muscle
    D S Jong
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510 8026
    J Gen Physiol 102:333-70. 1993
    ..mV were applied and the [Ca] transient measured with PDAA was used to estimate Ca release from the sarcoplasmic reticulum (SR) (Baylor, S. M., W. K. Chandler, and M. W. Marshall. 1983. Journal of Physiology. 344:625-666)...
  83. pmc Digoxin activates sarcoplasmic reticulum Ca(2+)-release channels: a possible role in cardiac inotropy
    S J McGarry
    Department of Cardiac Medicine, National Heart and Lung Institute, University of London
    Br J Pharmacol 108:1043-50. 1993
    1. The effect of digoxin on rapid 45Ca2+ efflux from cardiac and skeletal sarcoplasmic reticulum (SR) vesicles was investigated...
  84. ncbi The binding of monoclonal and polyclonal antibodies to the Ca2(+)-ATPase of sarcoplasmic reticulum: effects on interactions between ATPase molecules
    E Molnar
    Department of Biochemistry and Molecular Biology, State University of New York, Syracuse 13210
    Biochim Biophys Acta 1023:147-67. 1990
    ..of 14 monoclonal and 5 polyclonal anti-ATPase antibodies with the Ca2(+)-ATPase of rabbit sarcoplasmic reticulum and correlated the location of their epitopes with their effects on ATPase-ATPase interactions and Ca2+ ..
  85. ncbi Calreticulin, and not calsequestrin, is the major calcium binding protein of smooth muscle sarcoplasmic reticulum and liver endoplasmic reticulum
    R E Milner
    Cardiovascular Disease Research Group, University of Alberta, Edmonton, Canada
    J Biol Chem 266:7155-65. 1991
    ..Immunoblots of endoplasmic reticulum proteins probed with anti-calreticulin and anti-calsequestrin antibodies revealed that only calreticulin is ..
  86. ncbi Postmortem changes in the level of calcium pumping adenosine triphosphatase in rat heart sarcoplasmic reticulum
    Y Iwasa
    Third Department of Internal Medicine, University of Yamanashi Medical School, Japan
    Forensic Sci Int 39:13-22. 1988
    The activity of calcium pumping adenosine triphosphatase (Ca2+-ATPase) in cardiac sarcoplasmic reticulum plays a pivotal role in myocardiac contraction-relaxation...
  87. pmc Separate roles and different routing of calnexin and ERp57 in endoplasmic reticulum quality control revealed by interactions with asialoglycoprotein receptor chains
    Zehavit Frenkel
    Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Biol Cell 15:2133-42. 2004
    The thiol oxidoreductase endoplasmic reticulum (ER)p57 interacts with newly synthesized glycoproteins through ternary complexes with the chaperones/lectins calnexin or calreticulin...
  88. pmc Effect of cyclopiazonic acid, an inhibitor of sarcoplasmic reticulum Ca(2+)-ATPase, on the frequency-dependence of the contraction-relaxation cycle of the guinea-pig isolated atrium
    N J Yard
    Cardiovascular Biology Research Department, Ciba Geigy Ltd, Basel, Switzerland
    Br J Pharmacol 113:1001-7. 1994
    1. The relevance of a functional sarcoplasmic reticulum (SR) membrane system to the contraction-relaxation cycle and to the force-frequency relationship of guinea-pig atrial tissue was investigated...
  89. ncbi Drug-induced calcium release from heavy sarcoplasmic reticulum of skeletal muscle
    W Wyskovsky
    Institute of Pharmacology, University of Vienna, Austria
    Biochim Biophys Acta 938:89-96. 1988
    Calcium release from isolated heavy sarcoplasmic reticulum of rabbit skeletal muscle by several calmodulin antagonistic drugs was measured spectrophotometrically with arsenazo III and compared with the properties of the caffeine-induced ..
  90. ncbi [Effects of sarcoplasmic reticulum calcium ATPase 2a overexpression on endoplasmic reticulum stress in cardiomyocytes]
    Jian jun Dong
    Department of Geriatric Cardiology, General Hospital of People s Liberation Army, Beijing 100853, China
    Zhonghua Yi Xue Za Zhi 89:415-8. 2009
    To investigate the effects of sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) overexpression on the endoplasmic reticulum stress (ERS).
  91. ncbi Molecular cloning of cDNA encoding a 55-kDa multifunctional thyroid hormone binding protein of skeletal muscle sarcoplasmic reticulum
    L Fliegel
    Cardiovascular Disease Research Group, University of Alberta, Edmonton, Canada
    J Biol Chem 265:15496-502. 1990
    ..clone encoding 55-kDa multifunctional, thyroid hormone binding protein of rabbit skeletal muscle sarcoplasmic reticulum was isolated and sequenced...
  92. pmc Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle
    D Zhou
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Cell Biol 136:621-31. 1997
    ..ankyrins in rat and rabbit skeletal muscle and demonstrate their selective association with the sarcoplasmic reticulum. In frozen sections of rat skeletal muscle, antibodies to the spectrin-binding domain (anti-p65) react only with ..
  93. ncbi Interaction of bupivacaine and tetracaine with the sarcoplasmic reticulum Ca2+ release channel of skeletal and cardiac muscles
    H Komai
    Department of Anesthesiology, University of Wisconsin, Madison 53792 3272, USA
    Anesthesiology 90:835-43. 1999
    ..Research has suggested that an effect of bupivacaine on sarcoplasmic reticulum Ca2+ release is involved in its myotoxicity, but direct evidence is lacking...
  94. pmc Induction of protein body formation in plant leaves by elastin-like polypeptide fusions
    Andrew J Conley
    Department of Biology, University of Western Ontario, London, ON, Canada
    BMC Biol 7:48. 2009
    ..of elastin-like polypeptide protein fusions in various intracellular compartments and to elucidate elastin-like polypeptide's mechanism of action for increasing recombinant protein accumulation in the endoplasmic reticulum of plants.
  95. ncbi Effects of halothane on the sarcoplasmic reticulum Ca2+ stores and contractile proteins in rabbit pulmonary arteries
    J Y Su
    Department of Anesthesiology, University of Washington, Seattle 98195 6540, USA
    Anesthesiology 88:1096-106. 1998
    ..the mechanisms of direct effects of halothane on the contractile proteins and Ca2+ release from the sarcoplasmic reticulum Ca2+ stores using isolated skinned strips (sarcolemma permealized with saponin) from rabbit pulmonary arteries.
  96. pmc LysoPC acyltransferase/PC transacylase activities in plant plasma membrane and plasma membrane-associated endoplasmic reticulum
    Karin E Larsson
    Department of Plant and Environmental Sciences, Goteborg University, P O Box 461, SE 405 30 Goteborg, Sweden
    BMC Plant Biol 7:64. 2007
    The phospholipids of the plant plasma membrane are synthesized in the endoplasmic reticulum (ER). The majority of these lipids reach the plasma membrane independently of the secretory vesicular pathway...
  97. ncbi Distinct natures of beryllium fluoride-bound, aluminum fluoride-bound, and magnesium fluoride-bound stable analogues of an ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase: changes in catalytic and transport sites during ph
    Stefania Danko
    Department of Biochemistry, Asahikawa Medical College, Asahikawa 078 8510, Japan
    J Biol Chem 279:14991-8. 2004
    ..natures of stable analogues for the ADP-insensitive phosphoenzyme (E2P) of Ca(2+)-ATPase formed in sarcoplasmic reticulum vesicles, i.e. the enzymes with bound beryllium fluoride (BeF.E2), bound aluminum fluoride (AlF...
  98. ncbi Role of lipids in the assembly of endoplasmic reticulum and dictyosomes in neuronal cells from the cerebral cortex of Yakutian ground squirrel (Citellus undulatus) during hibernation
    I K Kolomiytseva
    Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia
    Biochemistry (Mosc) 68:783-94. 2003
    ..microsomal fraction to be an interconnected system of cisterns and vesicles, which corresponds to endoplasmic reticulum and dictyosomes (Golgi stacks) of intact neurons...
  99. pmc Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin
    Charles E Patterson
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas 75390 9039, USA
    Cell Stress Chaperones 10:285-95. 2005
    AFKBP65 (65-kDa FK506-binding protein) is an endoplasmic reticulum (ER)-localized peptidyl-prolyl cis-trans isomerase predicted to play a role in the folding and trafficking of secretory proteins...
  100. ncbi Assessment of sarcoplasmic reticulum Ca(2+) flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction
    Paul Neary
    Department of Medical Cardiology, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Pflugers Arch 444:360-71. 2002
    ..to correlate intracellular Ca(2+) transients with Ca(2+) uptake and efflux characteristics of the sarcoplasmic reticulum (SR) in ventricular myocytes isolated from rabbits with left-ventricular dysfunction (LVD)...
  101. pmc Effects of tetrandrine on calcium transport, protein fluorescences and membrane fluidity of sarcoplasmic reticulum
    L Y Chen
    Division of Biochemistry, Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    Br J Pharmacol 131:530-6. 2000
    ..whether the molecular mechanism of Tetrandrine (Tet)'s pharmacological effects is concerned with sarcoplasmic reticulum calcium transport so as to be involved in myocardial contractility, we observed the effects of Tet on calcium ..

Research Grants74

  1. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  2. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ..expression was substantially lower than H1RS, with H1RR exhibiting intracellular retention in the endoplasmic reticulum (ER)...
  3. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..5) pollution induces adipose dysfunction via reactive oxygen species (ROS)-dependent activation of endoplasmic reticulum (ER) stress and potentiation of insulin resistance. To achieve this goal, we first assess PM2...
  4. Regulation of ER stress-induced cell death
    Randal J Kaufman; Fiscal Year: 2013
    ..an adaptive signaling pathway to promote cell survival upon accumulation of unfolded protein in the endoplasmic reticulum (ER)...
  5. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..Regulation of the translation machinery during toxic conditions, such as endoplasmic reticulum (ER) stress, can arrest cell growth and promote the repair of damage or promote cell death...
  6. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..As a result there will be multiple repercussions to their defects or failures. It can be anticipated, therefore, that our research will have consequences outside its field of muscle and exercise. ..
  7. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..work revealed for the first time that the Na pump is completely functional once assembled within the endoplasmic reticulum. However, the potential physiological role of this intracellular activity remained a mystery...
  8. MODULATION OF IFN ACTION VIA NOVEL REGULATORY FACTORS
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..Notably, Activating transcription factor 6 (ATF6), a key regulator of endoplasmic reticulum-dependent stress responses, appears to regulate DAPK1 expression...
  9. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..The endoplasmic reticulum (ER or sarcoplasmic reticulum in cardiac myocytes) is a principal site for protein folding, calcium storage and ..
  10. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..One of the key abnormalities in both human and experimental HF is a defect in sarcoplasmic reticulum (SR) function, which is responsible for abnormal intracellular Ca2+ handling...
  11. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..quantify NO release, measure reactive oxygen species, determine the redox status of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), and assess intracellular Ca2+...
  12. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..aggregates that are associated with markedly disorganized intracellular organelles, including endoplasmic reticulum (ER) and mitochondria...
  13. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..The overall hypothesis is that NTs enhance a) sarcoplasmic reticulum (SR) Ca2+ release and Ca2+ influx;and b) Ca2+ sensitivity for force generation in ASM...
  14. Regulation of K-Ras by a Farnesyl-electrostatic Switch
    MARK REID PHILIPS; Fiscal Year: 2013
    ..of K-Ras from the plasma membrane and association with intracellular membranes, including the endoplasmic reticulum (ER), Golgi apparatus and the outer mitochondrial membrane...
  15. Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1
    RAJESH K ANEJA; Fiscal Year: 2013
    ..HMGB1 lacks a secretory signal peptide;therefore, it cannot be secreted via the endoplasmic reticulum-Golgi system. The newly synthesized HMGB1 undergoes extensive post-translational modifications, e.g...
  16. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    ..pancreatic lipids, fatty acid ethyl esters (FAEEs, nonoxidative lipid metabolites of ethanol) and endoplasmic reticulum (ER) stress in hepatic alcohol dehydrogenase (ADH)-deficient (ADH-) vs. normal ADH (ADH+) deer mice fed 3...
  17. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..The balance of fusion and fission dynamically regulates the integrity of the reticulum. Fusion is regulated by SNARE-like proteins called mitofusin-1 and mitofusin-2...
  18. A fully validated assay to identify activators of ERSR in human glioma cells: ide
    Maurizio Grimaldi; Fiscal Year: 2012
    ..of preliminary data indicating that glioma cells are sensible to cell death induced by triggering endoplasmic reticulum stress response (ERSR)...
  19. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    L Jeannine Brady; Fiscal Year: 2013
    ..living cells and involved in insertion and secretion of proteins into and through the cytoplasmic or endoplasmic reticulum membrane. Until it was demonstrated otherwise in S. mutans, the SRP pathway was considered essential. In S...
  20. High throughput screen for selective inhibitors of cyclophilin B
    Richard J Bram; Fiscal Year: 2013
    ..The endoplasmic reticulum (ER) resident prolyl isomerase Cyclophilin B (CypB) is highly up-regulated in multiple types of cancers...
  21. Cell stress, development, and stimulant-induced behavior: Regulation by GSK3
    Marjelo A Mines; Fiscal Year: 2012
    ..Endoplasmic reticulum (ER) stress, resulting from the accumulation of misfolded proteins, is associated with many diseases and ..
  22. Hepatic Steatosis and ER Stress-Inducible Transcription Factor CREBH
    Kezhong Zhang; Fiscal Year: 2013
    ..transcription factor CREBH (cyclic-AMP-response-element-binding protein H), which is activated by endoplasmic reticulum (ER) stress to mediate an acute-phase inflammatory response in the liver...
  23. Ca Signaling in Progression of Amyotrophic Lateral Sclerosis in Skeletal Muscle
    Jingsong Zhou; Fiscal Year: 2013
    ..This overload will further disrupt mitochondria-sarcoplasmic reticulum (SR) coupling and lead to altered Ca and reactive oxygen species (ROS) signaling...
  24. Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic Acids
    Papasani V Subbaiah; Fiscal Year: 2013
    ..structure, especially the raft domains of the plasma membrane, and the micro environment of the endoplasmic reticulum (ER)...
  25. Lipid Transport, Bile Acid Synthesis, and Cholesterol Homeostasis
    William M Pandak; Fiscal Year: 2013
    ..in NAFLD appears to produce injury in part by inducing the unfolded protein response (UPR) in the endoplasmic reticulum;a progression of similar events to those found with the development of atherosclerosis...
  26. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): CREB-H is an endoplasmic reticulum (ER)-bound transcription factor that is highly and selectively expressed only in the liver and the small intestine...
  27. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..regression is coupled with other degenerative changes in dendrites such as dilation of the smooth endoplasmic reticulum (SER), the major calcium storage component of PN dendrites...
  28. Molecular Pathological Mechanism & Potential Therapeutics of Lafora Disease
    YAN NONE LIU; Fiscal Year: 2010
    ..diseases are diverse abnormal aggregates formed inside or outside of affected neuronal cells and endoplasmic reticulum (ER) stress-induced neuronal apoptosis...
  29. The Mucolipin TRP Ion Channels
    Haoxing Xu; Fiscal Year: 2013
    ..Our third aim is to investigate the role of TRPML1 in lysosomal Ca2+ signaling. Like the endoplasmic reticulum (ER), lysosomes are also believed to be the Ca2+ release sites during certain cellular signaling...
  30. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ..Particular emphasis will be placed in amyloidogenesis, and endoplasmic reticulum (ER) stress, insulin signaling (insulin receptor substrate-2, IRS-2) and degradation (insulin degrading enzyme, ..
  31. The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2013
    ..112-HSD1 therefore plays a crucial role in local steroid reactivation. In the endoplasmic reticulum (ER) lumen, hexose-6-phosphate dehydrogenase (H6PDH) converts glucose-6-phosphate (G6P) and NADP to generate ..
  32. Enhance Production of Functional Recombinant Human Protein C Variant In Mammalian
    Nienwen Chow; Fiscal Year: 2010
    ..The other approach is to knock down endoplasmic reticulum (ER) stress/chaperone protein GRP78 to increase the efficiency of 5A-PC secretion...
  33. Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2
    David E Cohen; Fiscal Year: 2013
    ..insulin resistance due to overproduction of saturated free fatty acids, which in turn promote endoplasmic reticulum (ER) stress...
  34. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
    ..that ORMDL3 functions as a mediator of sphingolipid homeostasis in yeast and a regulator of endoplasmic reticulum-mediated Ca2+ signaling and cellular stress, very little is known regarding the role played by this protein in ..
  35. MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
    P Michael Conn; Fiscal Year: 2012
    ..proteins are detected by the cellular quality control system (QCS) and are typically retained in the endoplasmic reticulum (ER) for either reprocessing or degradation;frequently, these mutants result in disease...
  36. Effect of HIV protease inhibitor on alcohol induced ER stress and liver injury.
    Cheng Ji; Fiscal Year: 2013
    ..Emerging evidence indicates that the HIV PIs induce endoplasmic reticulum (ER) stress response which has been shown to play an essential role in liver dysfunction including ..
  37. Mechanisms of diet-induced leptin resistance in ARC and VTA
    Philip J Scarpace; Fiscal Year: 2013
    ..We suggest that diets that lead to over-consumption, exacerbated by fructose, promote inflammation, endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS) and these specifically inhibit leptin-mediated STAT3 ..
  38. Protein Modifications and Unfolded Protein Response in Diabetic Embryopathy
    Zhiyong Zhao; Fiscal Year: 2013
    ..chaperone proteins, which facilitate folding and processing of newly synthesized polypeptides in the endoplasmic reticulum (ER) and transporting out of its lumen...
  39. mTORC1-dependent regulation of the CycC/CDK8 complex
    Jeffrey E Pessin; Fiscal Year: 2013
    ..SREBP-1c transcription;2) protelytic maturation from its precursor that is initially located in endoplasmic reticulum membrane, and 3) increased nuclear SREBP-1c protein stability...
  40. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..gp96 (grp94, HSP90b) is a paralogue of HSP90 in the endoplasmic reticulum (ER) where the assembly of GPIb-IX-V complex occurs...
  41. Lipid Metabolism and Steatosis in Liver
    Amrita Kamat; Fiscal Year: 2013
    ..of hepatic lipid metabolism with distinct functions depending on its subcellular localization;in the endoplasmic reticulum (ER) it functions as a triglyceride (TG) synthetic enzyme, whereas in the nucleus it acts as a transcriptional ..
  42. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..Lipid flip-flop across the endoplasmic reticulum (ER) membrane is required for protein N-glycosylation and GPI-anchoring...
  43. Thiol Isomerases During Thrombus Formation
    Barbara C Furie; Fiscal Year: 2013
    ..Thiol isomerases are critical for disulfide bond formation during protein synthesis within the endoplasmic reticulum, but protein thiol isomerases located outside of the endoplasmic reticulum may be critical for regulation of ..
  44. HEPATIC DEGRADATION OF CYTOCHROME P450 ENZYMES
    Maria Almira Correia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The hepatic cytochromes P450 (P450s) are endoplasmic-reticulum membrane-anchored enzymes engaged in the breakdown of endo- and xenobiotics i.e...
  45. The Role of FKBP10 in Recessive Osteogenesis Imperfecta
    Caressa Lietman; Fiscal Year: 2013
    ..Protein 47 (HSP47) and together they are thought to be involved in chaperoning of collagen in the endoplasmic reticulum [4, 5]...
  46. Function and regulation of elemental Ca2+ signaling in urethral smooth muscle
    Ronghua Zhuge; Fiscal Year: 2013
    ..sparks") that result from the spontaneous opening of type 2 ryanodine receptors (RyR2) in the sarcoplasmic reticulum, and their ion channel targets in the plasma membrane in urethral smooth muscle (USM)...
  47. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
    ..plasma lipids is to inhibit apoB-lipoprotein biosynthesis, a process critically dependent on an endoplasmic reticulum (ER) resident chaperone, microsomal triglyceride transfer protein (MTP)...
  48. Genetically testing interactions of ER and oxidative stresses in retinal disease
    Douglas Gould; Fiscal Year: 2013
    ..Our preliminary data couple the basic cellular processes of endoplasmic reticulum (ER) homeostasis and detoxification of reactive oxygen species to retinal disease...
  49. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..SAA 1) is synthesized by SMCs in response to IL-1ct, 2) induces trafficking of cholesterol to the endoplasmic reticulum (ER), 3) down-regulates cholesterol and fatty acid synthesis and 4) decreases accumulation of cholesterol and ..
  50. Atherogenic mechanism of lipid peroxidation-derived aldehydes
    Sanjay Srivastava; Fiscal Year: 2013
    ..we propose to test hypothesis that accumulation of lipid-derived aldehydes in macrophages induces endoplasmic reticulum (ER) stress and triggers the unfolded protein response (UPR), leading to cytokine production and foam cell ..
  51. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2013
    ..C (PI-PLC), and the production of inositol phosphate 3 (IP3) leads to release of calcium from the endoplasmic reticulum. The increase in intracellular calcium can activate calcineurin, which dephosphorylates NFATc1 and promotes its ..
  52. Role of lipoxygenase pathway in early microvascular dysfunction during diabetic r
    MOHAMED AL SAYED AL-SHABRAWEY; Fiscal Year: 2013
    ..NADPH oxidase and endoplasmic reticulum (ER) are potential targets to the increased lipid metabolites of 12/15-LOX...
  53. METABOLIC REGULATION IN THE ACUTE PHASE
    HYUNG D RYOO; Fiscal Year: 2010
    ..The endoplasmic reticulum (ER), which handles the early post-translational processing of secreted proteins tries to maintain a balance ..
  54. Redox Regulation of SERCA by Nitric Oxide
    Richard A Cohen; Fiscal Year: 2013
    ..In the last period of funding, we identified the sarcoplasmic reticulum Ca2+ ATPase (SERCA) in vascular smooth muscle cells (SMC) to be stimulated by low levels of 7NO-derived RNS that ..
  55. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
    The Sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA) plays a dominant role in Ca2+ removal and is responsible for maintaining cardiac SR Ca2+ store...
  56. Bacterial Immunosuppression: Host Target Identification Through Chemical Probes
    Kim D Janda; Fiscal Year: 2013
    ..immune system effectors, exposure of mammalian cells to C12 resulted in activation of the endoplasmic reticulum (ER) stress response, protein kinase p38 pathway and apoptosis...
  57. Role of Central Neural NFkB and ER Stress in Obesity-induced Hypertension
    COLIN NEAL YOUNG; Fiscal Year: 2013
    ..In this regard, there is mounting evidence that angiotensinergic signaling and endoplasmic reticulum stress (ER stress) within the brain are key mechanisms in diet-induced obesity (DIO);however the downstream ..
  58. CFTR Biogenesis and Function in Epithelia
    Zsuzsa Bebok; Fiscal Year: 2012
    ..represses the transcription of genes through a promoter-specific mechanism;2) the UPR enhances endoplasmic reticulum-associated degradation (ERAD) by decreasing the expression of pro-folding chaperones and enhancing the level of ..
  59. Selenoprotein K modulates calcium-dependent signaling in immune cells
    PETER R HOFFMAN; Fiscal Year: 2013
    ..Our preliminary data indicate Sel K protein expression is highest in immune cells, localizing to the endoplasmic reticulum (ER) membrane in T cells, monocytes, and macrophages...
  60. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..surface (including cell adhesion molecules and signaling receptors) are produced and folded by the endoplasmic reticulum (ER). If the ER has problems folding these proteins, a compensatory "ER stress response" (a.k.a...
  61. Identification of Inhibitors that Stabilize ER Degradation Substrates
    Domenico Tortorella; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Newly synthesized endoplasmic reticulum (ER) proteins are subjected to inspection by the ER quality control machinery to ensure that only properly folded molecules can traffic to their final ..
  62. Characterizaton of Motility Factor Receptor
    Avraham Raz; Fiscal Year: 2012
    ..is an orphan chemokine receptor, (gp78/AMFR/CXC2CR-1) that performs an additional function in the endoplasmic reticulum (ER) with an intrinsic RING finger-dependent ubiquitin protein ligase (E3) activity...
  63. ACTIONS OF CYCLIC GMP IN SMOOTH MUSCLE
    Thomas Lincoln; Fiscal Year: 1999
    ..It has recently been shown that cGMP kinase is localized to the sarcoplasmic reticulum of rat aortic vascular smooth muscle cells, and catalyzes the phosphorylation of proteins that regulate the ..
  64. Alteration of ER:mitochondrial contacts by human cytomegalovirus infection
    ANAMARIS MARTHA COLBERG POLEY; Fiscal Year: 2010
    ..Following synthesis, UL37 proteins are translocated into the endoplasmic reticulum (ER) membrane and then imported into mitochondria, where they have potent anti- apoptotic functions...
  65. OXYGEN RADICALS, OXIDANTS AND MEMBRANE DYSFUNCTION
    RAKESH KUKREJA; Fiscal Year: 1990
    ..hypothesized that the major target organelles injured by free radical attack are the sarcolemma and sarcoplasmic reticulum which are the key regulators of myocardial contractility...
  66. MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETION
    David Cohen; Fiscal Year: 2000
    ..in submicellar concentrations promote transfer of biliary phosphatidylcholine molecules from smooth endoplasmic reticulum to canalicular plasma membranes via a specific phosphatidylcholine transfer protein (PC-TP)...
  67. Endoplasmic reticulum stress and foam cell formation
    Zhongmao Guo; Fiscal Year: 2010
    ..The goal of this proposal is to determine the involvement of endoplasmic reticulum stress in foam cell formation...
  68. CA2+ RELEASE CHANNEL FROM CARDIAC SARCOPLASMIC RETICULUM
    Kevin Campbell; Fiscal Year: 1991
    The overall goal of my research is to understand the mechanism of Ca2+ release from the junctional sarcoplasmic reticulum of cardiac muscle...
  69. SIGNAL PEPTIDASE STRUCTURE AND FUNCTION
    MARK LIVELY; Fiscal Year: 1999
    ..proteolytic enzyme that cleaves signal peptides from secretory proteins targeted to the lumen of the endoplasmic reticulum. The enzyme activity is associated with a complex of from two to five integral membrane proteins with their ..
  70. REGULATION OF SARCOPLASMIC RETICULUM CA2+ RELEASE
    Gerhard Meissner; Fiscal Year: 2009
    ..is to understand the multifaceted mechanisms that control the activity of two skeletal muscle sarcoplasmic reticulum Ca2+ release channels, the ryanodine receptors RyR1 and RyR3...
  71. ENDOPLASMIC RETICULUM IN SEA URCHIN EGG
    BENJAMIN KAMINER; Fiscal Year: 1990
    Our long-term objective is to gain an understanding of the role of the smooth endoplasmic reticulum (SER) a regulator of extracellular calcium, which acts as a messenger and modulator of numerous events following fertilization of the egg...
  72. SURFACE MEMBRANES IN NORMAL AND CANCER CELLS
    Paul Atkinson; Fiscal Year: 1991
    Cloned endoplasmic reticulum membrane glycoprotein genes will be used to probe the primary sequence requirements directing the sorting of glycoproteins into specific membrane compartments...
  73. From Unfolded Proteins in the ER to Disease
    Linda Hendershot; Fiscal Year: 2009
    ..proteins destined for the cell surface or for the external milieu are first translocated into the endoplasmic reticulum (ER) where initial protein folding and modifications occur that are essential for the protein to attain its ..
  74. Effects--Ethanol--Dendritic Smooth Endoplasmic Reticulum
    Cynthia Dlugos; Fiscal Year: 2003
    ..periods of ethanol consumption result in dendritic regression and dilatation of the dendritic smooth endoplasmic reticulum (SER) within the extensive dendritic arbor of PN...