rotavirus

Summary

Summary: A genus of REOVIRIDAE, causing acute gastroenteritis in BIRDS and MAMMALS, including humans. Transmission is horizontal and by environmental contamination. Seven species (Rotaviruses A thru G) are recognized.

Top Publications

  1. ncbi 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis
    Jacqueline E Tate
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    Lancet Infect Dis 12:136-41. 2012
  2. pmc Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)
    Jelle Matthijnssens
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium
    Arch Virol 156:1397-413. 2011
  3. ncbi Effect of human rotavirus vaccine on severe diarrhea in African infants
    Shabir A Madhi
    Department of Science and Technology National Research Foundation Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
    N Engl J Med 362:289-98. 2010
  4. pmc Rotavirus infection induces the unfolded protein response of the cell and controls it through the nonstructural protein NSP3
    Vicenta Trujillo-Alonso
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, Mexico
    J Virol 85:12594-604. 2011
  5. ncbi United States rotavirus strain surveillance from 2005 to 2008: genotype prevalence before and after vaccine introduction
    Jennifer J Hull
    Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Pediatr Infect Dis J 30:S42-7. 2011
  6. ncbi Infant rotavirus vaccination may provide indirect protection to older children and adults in the United States
    Ben A Lopman
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 204:980-6. 2011
  7. ncbi Fulfilling the promise of rotavirus vaccines: how far have we come since licensure?
    Manish M Patel
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet Infect Dis 12:561-70. 2012
  8. ncbi Zoonotic aspects of rotaviruses
    V Martella
    Department of Veterinary Public Health, University of Bari, Bari, Italy
    Vet Microbiol 140:246-55. 2010
  9. pmc Burden of rotavirus gastroenteritis in the Middle Eastern and North African pediatric population
    Hanane Khoury
    BioMedCom Consultants Inc, 1405 TransCanada Highway, Suite 310, Montreal, Quebec H9P 2V9, Canada
    BMC Infect Dis 11:9. 2011
  10. ncbi Burden of rotavirus gastroenteritis and distribution of rotavirus strains in Asia: a systematic review
    Kosuke Kawai
    Temple University, School of Pharmacy, 3307N Broad Street, Philadelphia, PA 19140, USA
    Vaccine 30:1244-54. 2012

Detail Information

Publications327 found, 100 shown here

  1. ncbi 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis
    Jacqueline E Tate
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    Lancet Infect Dis 12:136-41. 2012
    WHO recommends routine use of rotavirus vaccines in all countries, particularly in those with high mortality attributable to diarrhoeal diseases...
  2. pmc Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)
    Jelle Matthijnssens
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium
    Arch Virol 156:1397-413. 2011
    ..The Rotavirus Classification Working Group (RCWG) was formed by scientists in the field to maintain, evaluate and develop the ..
  3. ncbi Effect of human rotavirus vaccine on severe diarrhea in African infants
    Shabir A Madhi
    Department of Science and Technology National Research Foundation Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
    N Engl J Med 362:289-98. 2010
    b>Rotavirus is the most common cause of severe gastroenteritis among young children worldwide. Data are needed to assess the efficacy of the rotavirus vaccine in African children.
  4. pmc Rotavirus infection induces the unfolded protein response of the cell and controls it through the nonstructural protein NSP3
    Vicenta Trujillo-Alonso
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, Mexico
    J Virol 85:12594-604. 2011
    ..To understand the cellular events that occur during the rotavirus replication cycle, we examined the activation of the three UPR arms following infection, using luciferase ..
  5. ncbi United States rotavirus strain surveillance from 2005 to 2008: genotype prevalence before and after vaccine introduction
    Jennifer J Hull
    Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Pediatr Infect Dis J 30:S42-7. 2011
    A live, attenuated rotavirus vaccine, RotaTeq®, was approved in 2006 for immunization of infants in the United States...
  6. ncbi Infant rotavirus vaccination may provide indirect protection to older children and adults in the United States
    Ben A Lopman
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 204:980-6. 2011
    Following the introduction of rotavirus vaccination in the United States, rotavirus and cause-unspecified gastroenteritis discharges significantly decreased in 2008 in the 0-4, 5-14, and 15-24-year age groups, with significant reductions ..
  7. ncbi Fulfilling the promise of rotavirus vaccines: how far have we come since licensure?
    Manish M Patel
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet Infect Dis 12:561-70. 2012
    b>Rotavirus is the most common cause of fatal and severe childhood diarrhoea worldwide. Two new rotavirus vaccines have shown efficacy against severe rotavirus disease in large clinical trials...
  8. ncbi Zoonotic aspects of rotaviruses
    V Martella
    Department of Veterinary Public Health, University of Bari, Bari, Italy
    Vet Microbiol 140:246-55. 2010
    ..b>Rotavirus-associated enteritis is a major problem in livestock animals, notably in young calves and piglets...
  9. pmc Burden of rotavirus gastroenteritis in the Middle Eastern and North African pediatric population
    Hanane Khoury
    BioMedCom Consultants Inc, 1405 TransCanada Highway, Suite 310, Montreal, Quebec H9P 2V9, Canada
    BMC Infect Dis 11:9. 2011
    b>Rotavirus gastroenteritis (RVGE) is the most common cause of severe childhood diarrhea worldwide...
  10. ncbi Burden of rotavirus gastroenteritis and distribution of rotavirus strains in Asia: a systematic review
    Kosuke Kawai
    Temple University, School of Pharmacy, 3307N Broad Street, Philadelphia, PA 19140, USA
    Vaccine 30:1244-54. 2012
    b>Rotavirus is the leading cause of severe diarrhea in children worldwide. We systematically reviewed the burden of rotavirus gastroenteritis (RVGE) and distribution of rotavirus strains in Asia.
  11. ncbi Rapid generation of rotavirus-specific human monoclonal antibodies from small-intestinal mucosa
    Roberto Di Niro
    Center for Immune Regulation, Oslo University Hospital, Oslo, Norway
    J Immunol 185:5377-83. 2010
    ..Using eGFP-labeled virus-like particles, we harnessed the surface Ig expression to detect rotavirus-specific plasma cells at low frequency (0.03-0.35%) in 9 of 10 adult subjects...
  12. ncbi Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial
    George E Armah
    Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
    Lancet 376:606-14. 2010
    b>Rotavirus gastroenteritis causes many deaths in infants in sub-Saharan Africa...
  13. ncbi Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study
    Alexandre C Linhares
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministry of Health, Belem, Para, Brazil
    Lancet 371:1181-9. 2008
    Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months of age...
  14. pmc Innate immune responses to human rotavirus in the neonatal gnotobiotic piglet disease model
    Ana M Gonzalez
    Department of Veterinary Preventive Medicine, Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
    Immunology 131:242-56. 2010
    ..dendritic cell (DC) frequencies, serum and small intestinal content cytokines and uptake/binding of human rotavirus (HRV) virus-like particles (VLP) were studied in HRV acutely infected or mock-inoculated neonatal gnotobiotic ..
  15. ncbi Rotavirus incidence and genotype distribution before and after national rotavirus vaccine introduction in Belgium
    Mark Zeller
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Vaccine 28:7507-13. 2010
    ..The incidence of rotavirus gastroenteritis has been monitored in the Gasthuisberg University Hospital (GUH), Belgium since 1986, and since ..
  16. ncbi Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer
    Rahul C Deo
    Laboratories of Molecular Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 108:71-81. 2002
    ..Biophysical studies demonstrate high affinity binding leading to increased thermal stability and slow dissociation kinetics, consistent with NSP3 function...
  17. ncbi Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries
    Javier Diez-Domingo
    Area de Investigación en Vacunas, Centro Superior de Investigación en Salud Pública, CSISP, Centre for Public Health Research, Avda Catalunya 21, 46020 Valencia, Spain
    Eur J Pediatr 170:213-22. 2011
    This observational, prospective study was undertaken to estimate the burden of rotavirus (RV) gastroenteritis (GE) leading to general practitioner (GP)/family paediatrician (FP) visits among children aged <5 years in Czech Republic, ..
  18. pmc Heterologous protection induced by the inner capsid proteins of rotavirus requires transcytosis of mucosal immunoglobulins
    Isabelle Schwartz-Cornil
    U892 INRA, Domaine de Vilvert, 78352 Jouy en Josas, France
    J Virol 76:8110-7. 2002
    Protective immunization against rotavirus (RV) can be achieved with heterologous RV, i.e., virus isolated from another species, and with heterologous inner core VP2 and VP6 proteins assembled as virus-like particles (VLP)...
  19. ncbi Characterization of group A rotavirus infections in adolescents and adults from Pune, India: 1993-1996 and 2004-2007
    Vaishali S Tatte
    Rotavirus Group, National Institute of Virology, Pune, India
    J Med Virol 82:519-27. 2010
    ..from adolescents and adults with acute gastroenteritis in Pune, India for detection and characterization of rotavirus. At the two time points, group A rotavirus was detected in 8.6% and 16.2% of the adolescents and 5.2% and 17...
  20. pmc Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility
    Johanna Pott
    Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Germany
    PLoS Pathog 8:e1002670. 2012
    b>Rotavirus is a major cause of diarrhea worldwide and exhibits a pronounced small intestinal epithelial cell (IEC) tropism...
  21. pmc Rotavirus
    U D Parashar
    Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 4:561-70. 1998
    b>Rotavirus, the most common diarrheal pathogen in children worldwide, causes approximately one third of diarrhea-associated hospitalizations and 800,000 deaths per year...
  22. ncbi Universal mass vaccination against rotavirus gastroenteritis: impact on hospitalization rates in austrian children
    Maria Paulke-Korinek
    Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology, Pathophysiology and Immunology, Medical University Vienna, Vienna, Austria
    Pediatr Infect Dis J 29:319-23. 2010
    Since July 2007, rotavirus vaccinations have been subsidized in Austria for all children from the seventh week up to the sixth month of life. Vaccination coverage over the whole period was 72% with an increase to 87% in 2008.
  23. ncbi Rotavirus strain types circulating in Africa: Review of studies published during 1997-2006
    Stacy Todd
    Royal Liverpool University Hospital, University of Liverpool, United Kingdom
    J Infect Dis 202:S34-42. 2010
    b>Rotavirus is responsible for more than half a million deaths among infants and young children worldwide each year; many of these deaths could be prevented by widespread use of an effective rotavirus vaccine...
  24. pmc Protein kinase R is responsible for the phosphorylation of eIF2alpha in rotavirus infection
    Margarito Rojas
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, UNAM, Cuernavaca, Morelos 62210, Mexico
    J Virol 84:10457-66. 2010
    ..Early during rotavirus infection, eIF2α becomes phosphorylated, and even under these conditions viral protein synthesis is not ..
  25. pmc Rotavirus and reovirus modulation of the interferon response
    Barbara Sherry
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Interferon Cytokine Res 29:559-67. 2009
    ..b>Rotavirus likely represses the IFN response by at least 4 mechanisms...
  26. ncbi Role of rotaviruses in children with acute diarrhea in Tehran, Iran
    A H Zarnani
    Department of Virology, Pasteur Institute of Iran, Tehran, Iran
    J Clin Virol 29:189-93. 2004
    b>Rotavirus illness is associated with significant cause of morbidity and is a common cause of hospitalization worldwide.
  27. pmc Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms
    Z Berkova
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030 3404, USA
    J Virol 80:6061-71. 2006
    b>Rotavirus is a major cause of infantile viral gastroenteritis. Rotavirus nonstructural protein 4 (NSP4) has pleiotropic properties and functions in viral morphogenesis as well as pathogenesis...
  28. pmc Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism
    Joel W Graff
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America
    PLoS Pathog 5:e1000280. 2009
    ..b>Rotavirus nonstructural protein NSP1 blocks transcription of type I IFNalpha/beta by inducing proteasome-dependent ..
  29. ncbi Rotavirus genotyping: keeping up with an evolving population of human rotaviruses
    Miren Iturriza-Gomara
    Enteric Virus Unit, Enteric Respiratory and Neurological Virus Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, 61 Colindale Avenue, London NW9 5HT, UK
    J Clin Virol 31:259-65. 2004
    The use of molecular methods for rotavirus characterisation provides not only increased sensitivity for typing, but also allows accurate and more complete characterisation of strains, and the identification of putative reassortant ..
  30. pmc Global seasonality of rotavirus infections
    S M Cook
    Viral Gastroenteritis Unit, Centers for Disease Control, Atlanta, GA 30333
    Bull World Health Organ 68:171-7. 1990
    ..34 studies of the etiology of childhood diarrhoea were compiled in order to investigate the seasonal patterns of rotavirus gastroenteritis and consider their implications for transmission of the virus...
  31. pmc The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3
    Adrish Sen
    Department of Microbiology, Stanford University, Stanford, CA 94305 5101, USA
    J Virol 85:3717-32. 2011
    In mouse embryonic fibroblasts (MEFs), the bovine rotavirus (UK strain) but not the simian rhesus rotavirus (RRV) robustly triggers beta interferon (IFN-β) secretion, resulting in an IFN-dependent restriction of replication...
  32. pmc Rotavirus vaccines: an overview
    Penelope H Dennehy
    Division of Pediatric Infectious Diseases, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Clin Microbiol Rev 21:198-208. 2008
    b>Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and continues to have a major global impact on childhood morbidity and mortality...
  33. ncbi RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium
    Alexis H Broquet
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 186:1618-26. 2011
    b>Rotavirus is a dsRNA virus that infects epithelial cells that line the surface of the small intestine. It causes severe diarrheal illness in children and ∼500,000 deaths per year worldwide...
  34. ncbi Age distribution of paediatric rotavirus gastroenteritis cases in Europe: the REVEAL study
    Carlo Giaquinto
    Department of Paediatrics, University of Padua, Via Giustiniani 3, Padua, Italy
    Scand J Infect Dis 42:142-7. 2010
    b>Rotavirus is the most frequent cause of severe diarrhoea in children aged <5 y. A prospective, multicentre, observational study was conducted in Europe during the 2004-2005 rotavirus season...
  35. pmc Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab
    Scott T Aoki
    Laboratory of Molecular Medicine, Children s Hospital, Boston, MA 02115, USA
    Science 324:1444-7. 2009
    b>Rotavirus outer-layer protein VP7 is a principal target of protective antibodies...
  36. ncbi Rotavirus genome replication and morphogenesis: role of the viroplasm
    J T Patton
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8026, Room 6314, Bethesda, MD 20892 8026, USA
    Curr Top Microbiol Immunol 309:169-87. 2006
    ..A characteristic feature of rotavirus-infected cells is the formation of large cytoplasmic inclusion bodies, termed viroplasms...
  37. ncbi Decline and change in seasonality of US rotavirus activity after the introduction of rotavirus vaccine
    Jacqueline E Tate
    Division of Viral Diseases, Centers for Disease Control andPrevention, Atlanta, Georgia 30333, USA
    Pediatrics 124:465-71. 2009
    In 2006, routine immunization of US infants against rotavirus was initiated. We assessed national, regional, and local trends in rotavirus testing and detection before and after vaccine introduction.
  38. ncbi Symptomatic and asymptomatic infections of rotavirus, norovirus, and adenovirus among hospitalized children in Xi'an, China
    Shuwan Zhang
    The First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    J Med Virol 83:1476-84. 2011
    b>Rotavirus (RV), norovirus (NoV), and adenovirus (AdV) have been reported as the common viral pathogens of acute gastroenteritis in children...
  39. ncbi Characterization of rotavirus NSP2/NSP5 interactions and the dynamics of viroplasm formation
    Catherine Eichwald
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    J Gen Virol 85:625-34. 2004
    Viroplasms are discrete structures formed in the cytoplasm of rotavirus-infected cells and constitute the replication machinery of the virus...
  40. ncbi Reduction in pediatric rotavirus-related hospitalizations after universal rotavirus vaccination in Belgium
    Marc Raes
    Paediatric Department, Virga Jesse Ziekenhuis, Stadsomvaart 11, Hasselt, Belgium
    Pediatr Infect Dis J 30:e120-5. 2011
    This study investigated the effect of pediatric vaccination against rotavirus on the number of rotavirus-related hospitalizations of children in Belgium.
  41. ncbi Estimated mortality and hospital admission due to rotavirus infection in the WHO European region
    C J Williams
    Health Protection Agency Centre for Infections, London, UK
    Epidemiol Infect 137:607-16. 2009
    In 2006 two rotavirus vaccines were licensed for use in young children in Europe...
  42. ncbi Enhancement of detection and quantification of rotavirus in stool using a modified real-time RT-PCR assay
    Molly M Freeman
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Med Virol 80:1489-96. 2008
    A sensitive and specific real-time RT-PCR assay to detect rotavirus in stool samples was optimized and validated using a wide range of rotavirus genotypes...
  43. pmc Cohort study of Guinean children: incidence, pathogenicity, conferred protection, and attributable risk for enteropathogens during the first 2 years of life
    Palle Valentiner-Branth
    Bandim Health Project, The National Public Health Laboratory, Bissau, Guinea Bissau
    J Clin Microbiol 41:4238-45. 2003
    ..Standard estimation of the population attributable risk indicated that rotavirus, enterotoxigenic Escherichia coli that produced only the heat-stable toxin ST, Isospora spp...
  44. ncbi Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan
    Romena Qazi
    Department of Pathology and Microbiology, The Aga Khan University, Stadium Road, Karachi, Pakistan
    Vaccine 27:F25-30. 2009
    The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan...
  45. ncbi Epidemiology and economic burden of rotavirus gastroenteritis in hospitals and paediatric clinics in Taiwan, 2005-2006
    T Christopher Mast
    Merck and Co, Inc, PO Box 1000, North Wales, PA 19486, USA
    Vaccine 28:3008-13. 2010
    Baseline estimates of rotavirus disease burden and epidemiology are useful for the evaluation of newly introduced rotavirus vaccination programs...
  46. pmc Inhibition of rotavirus replication by a non-neutralizing, rotavirus VP6-specific IgA mAb
    Ningguo Feng
    Department of Gastroenterology, Stanford University School of Medicine, Stanford, California 94304, USA
    J Clin Invest 109:1203-13. 2002
    ..Intestinal mucosal IgA responses play a critical role in protective immunity against rotavirus reinfection...
  47. pmc Inadequately treated wastewater as a source of human enteric viruses in the environment
    Anthony I Okoh
    Applied and Environmental Microbiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Alice 5700, South Africa
    Int J Environ Res Public Health 7:2620-37. 2010
    ..This paper reviews the major genera of pathogenic human enteric viruses, their pathogenicity and epidemiology, as well as the role of wastewater effluents in their transmission...
  48. pmc Molecular detection and characterization of gastroenteritis viruses occurring naturally in the stream waters of Manaus, central Amazonia, Brazil
    Marize P Miagostovich
    Laboratório de Virologia Comparada, Pavilhão Cardoso Fontes, Av Brasil 4 365, Manguinhos, CEP 21040 360, Rio de Janeiro, RJ, Brazil
    Appl Environ Microbiol 74:375-82. 2008
    ..At least one virus was detected in 59.6% (31/52) of the water samples analyzed, and rotavirus was the most frequent (44.2%), followed by human adenovirus (30.8%), human astrovirus (15.4%), and norovirus (5...
  49. ncbi Substantial morbidity for hospitalized children with community-acquired rotavirus infections: 2005-2007 IMPACT surveillance in Canadian hospitals
    Nicole Le Saux
    Division of Infectious Diseases, CHEO Research Institute, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Pediatr Infect Dis J 29:879-82. 2010
    We describe community-acquired rotavirus illness in 1359 children hospitalized at 12 centers in Canada between January 2005 and December 2007. The median age was 1.5 years. Almost half (48...
  50. ncbi In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus
    Márcia Cristina Carriel-Gomes
    Laboratorio de Virologia Aplicada, Departamento de Ciencias Farmaceuticas, Universidade Federal de Santa Catarina, Florianopolis, Brasil
    Mem Inst Oswaldo Cruz 102:469-72. 2007
    ..different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11...
  51. ncbi Rotavirus-neutralizing antibodies inhibit virus binding to integrins alpha 2 beta 1 and alpha 4 beta 1
    F E Fleming
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia
    Arch Virol 152:1087-101. 2007
    b>Rotavirus outer capsid proteins VP5(*), VP8(*) and VP7 elicit neutralizing, protective antibodies. The alpha 2 beta 1 integrin is a cellular receptor for rotavirus that is bound by VP5(*)...
  52. pmc Rotavirus infection activates the UPR but modulates its activity
    Jose Luis Zambrano
    Immunology and Infectious Diseases, Montana State University, Bozeman, MT 59718, USA
    Virol J 8:359. 2011
    ..The purpose of this study was to identify changes in the cellular proteome in response to rotavirus infection in the context of the IFN response...
  53. ncbi Rotavirus and rotavirus vaccines
    Roger I Glass
    Viral Gastroenteritis Section, CDC, Atlanta, GA 30333, USA
    Adv Exp Med Biol 582:45-54. 2006
    Two new rotavirus vaccines have recently been licensed that will provide the intervention needed to diminish the huge burden of rotavirus disease among all children...
  54. pmc Uncoupling substrate and activation functions of rotavirus NSP5: phosphorylation of Ser-67 by casein kinase 1 is essential for hyperphosphorylation
    Catherine Eichwald
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Proc Natl Acad Sci U S A 101:16304-9. 2004
    b>Rotavirus NSP5 is a nonstructural protein that localizes in viroplasms of virus-infected cells. NSP5 interacts with NSP2 and undergoes a complex posttranslational hyperphosphorylation, generating species with reduced PAGE mobility...
  55. ncbi Genomic characterization of human rotavirus G8 strains from the African rotavirus network: relationship to animal rotaviruses
    M D Esona
    Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, NCIRD, CDC, Atlanta, Georgia 30333, USA
    J Med Virol 81:937-51. 2009
    Global rotavirus surveillance has led to the detection of many unusual human rotavirus (HRV) genotypes...
  56. ncbi Increased detection of rotavirus using a real time reverse transcription-polymerase chain reaction (RT-PCR) assay in stool specimens from children with diarrhea
    Xiaoli L Pang
    Provincial Laboratory for Public Health Microbiology, University Alberta Hospital, Edmonton, Alberta, Canada
    J Med Virol 72:496-501. 2004
    ..and twenty-six stool specimens collected from children with diarrhea over a 12-month period were tested for rotavirus using a real time reverse transcription-polymerase chain reaction (RT-PCR) assay, a conventional nested PCR ..
  57. pmc Protective immunity induced by oral immunization with a rotavirus DNA vaccine encapsulated in microparticles
    S C Chen
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Virol 72:5757-61. 1998
    ..In a murine model, we obtained protective immune responses after oral immunization with a rotavirus VP6 DNA vaccine encapsulated in poly(lactide-coglycolide) (PLG) microparticles...
  58. ncbi A systematic review of rotavirus strain diversity in India, Bangladesh, and Pakistan
    Melody G Miles
    PATH, Seattle, WA, USA
    Vaccine 30:A131-9. 2012
    Of the estimated half-million deaths from rotavirus globally each year, approximately one-third (N = 160,000 deaths) occur in the Indian subcontinent (defined as India, Bangladesh, and Pakistan)...
  59. ncbi Identification of G8 rotavirus strains determined as G12 by rotavirus genotyping PCR: updating the current genotyping methods
    Farah Aladin
    Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London, NW9 5HT, United Kingdom
    J Clin Virol 47:340-4. 2010
    ..There are presently a number of different rotavirus strains co-circulating within the UK, with the common human strains G1P[8], G2P[4] and G9P[8] being the most ..
  60. ncbi Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: insights for understanding the impact of rotavirus vaccination programs
    Krisztian Banyai
    Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary
    Vaccine 30:A122-30. 2012
    Recently, two rotavirus vaccines have been recommended for routine immunization of infants worldwide...
  61. pmc Cost-effectiveness of rotavirus vaccination in the Netherlands; the results of a consensus model
    Mark H Rozenbaum
    Unit of PharmacoEpidemiology and PharmacoEconomics PE2, Department of Pharmacy, University of Groningen, Groningen, The Netherlands
    BMC Public Health 11:462. 2011
    Each year rotavirus gastroenteritis results in thousands of paediatric hospitalisations and primary care visits in the Netherlands...
  62. pmc Genetic characterization of a novel, naturally occurring recombinant human G6P[6] rotavirus
    Mustafizur Rahman
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University Hospital Gasthuisberg, University of Leuven, BE 3000 Leuven, Belgium
    J Clin Microbiol 41:2088-95. 2003
    ..We report a human rotavirus strain (B1711) with a novel genotypic VP7/VP4 combination of G6P[6]...
  63. pmc Great diversity of group A rotavirus strains and high prevalence of mixed rotavirus infections in India
    V Jain
    Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 39:3524-9. 2001
    We previously observed a marked diversity of rotavirus strains and a high prevalence of the uncommon serotype G9 in a small survey of rotavirus strains collected from six centers in India...
  64. ncbi Molecular epidemiology of rotavirus infection in Western Cameroon
    Mathew D Esona
    MRC Medunsa Diarrhoeal Pathogens Research Unit, Medical University of Southern Africa, Pretoria, Republic of South Africa
    J Trop Pediatr 49:160-3. 2003
    b>Rotavirus is the major viral cause of diarrhoea in children worldwide. In this study, the first from Cameroon, the molecular epidemiology of rotavirus infection was investigated...
  65. ncbi Genetic and antigenic diversity of human rotaviruses: potential impact on vaccination programs
    Carl D Kirkwood
    Murdoch Childrens Research Institute, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    J Infect Dis 202:S43-8. 2010
    The successful development and implementation of rotavirus vaccines will have a significant impact on rotavirus-induced gastroenteritis in children worldwide...
  66. ncbi Rotavirus genotypes co-circulating in Europe between 2006 and 2009 as determined by EuroRotaNet, a pan-European collaborative strain surveillance network
    M Iturriza-Gomara
    Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency HPA, London, UK
    Epidemiol Infect 139:895-909. 2011
    EuroRotaNet, a laboratory network, was established in order to determine the diversity of co-circulating rotavirus strains in Europe over three or more rotavirus seasons from 2006/2007 and currently includes 16 countries...
  67. ncbi Determination of the G and P types of previously nontypeable rotavirus strains from the African Rotavirus Network, 1996-2004: Identification of unusual G types
    Mathew Dioh Esona
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 202:S49-54. 2010
    A total of 215 nontypeable rotavirus samples collected from children <5 years of age by members of the African Rotavirus Network were characterized using reverse-transcription polymerase chain reaction analysis and sequencing...
  68. ncbi Rotavirus disease and its prevention
    Marc Alain Widdowson
    Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Curr Opin Gastroenterol 21:26-31. 2005
    b>Rotavirus infection is the foremost cause of severe gastroenteritis of young children worldwide...
  69. ncbi Enteric viruses in pediatric diarrhea in Saudi Arabia
    Hamsa T Tayeb
    Molecular Virology and Infectious Diseases Section, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Med Virol 80:1919-29. 2008
    ..Each sample was tested for rotavirus, and astrovirus by ELISA, G and P type was determined for all rotaviruses...
  70. ncbi Global rotavirus surveillance: determining the need and measuring the impact of rotavirus vaccines
    Marc Alain Widdowson
    National Center for Immunizations and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    J Infect Dis 200:S1-8. 2009
    b>Rotavirus remains the most common cause of severe childhood diarrhea worldwide and of diarrheal mortality in poor countries...
  71. pmc Predominance and circulation of enteric viruses in the region of Greater Cairo, Egypt
    Aziza H Kamel
    Laboratory of Virology, National Reference Center for Enteric Viruses, Public Hospital of Dijon, Dijon, France
    J Clin Microbiol 47:1037-45. 2009
    ..At least one virus was detected in 50% of fecal samples, 57.4% of which were positive for rotavirus, 26% for norovirus, 10.4% for adenovirus, and 1.7% for astrovirus. Over 10% of infections were mixed infections...
  72. pmc Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh
    Firdausi Qadri
    International Centre for Diarrheal Disease Research, Laboratory Sciences Division B, Dhaka 1000, Bangladesh
    Infect Immun 75:3961-8. 2007
    ..5% cases, with an incidence of 0.5 episode/child/year. The prevalence of rotavirus diarrhea was lower (10%). ETEC expressing the heat-stable enterotoxin (ST) was predominant...
  73. ncbi Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine
    Timo Vesikari
    University of Tampere Medical School, Tampere, Finland
    N Engl J Med 354:23-33. 2006
    b>Rotavirus is a leading cause of childhood gastroenteritis and death worldwide.
  74. pdf Detection and molecular characterization of enteric viruses in environmental samples in Monastir, Tunisia between January 2003 and April 2007
    K Sdiri-Loulizi
    Laboratory of Infectious Diseases and Biological Agents, Faculty of Pharmacy, Monastir, Tunisia
    J Appl Microbiol 109:1093-104. 2010
    ....
  75. pmc Silencing the morphogenesis of rotavirus
    Tomàs López
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    J Virol 79:184-92. 2005
    ..In this work, we have characterized the role of NSP4 and VP7 in rotavirus morphogenesis by silencing the expression of both glycoproteins through RNA interference...
  76. pmc Genomic analysis of codon, sequence and structural conservation with selective biochemical-structure mapping reveals highly conserved and dynamic structures in rotavirus RNAs with potential cis-acting functions
    Wilson Li
    Department of Medicine, University of Cambridge, Level 5, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Nucleic Acids Res 38:7718-35. 2010
    ..Using a database of 1621 full-length sequences of mammalian group A rotavirus RNA segments, we evaluated the codon, sequence and RNA structural conservation of the complete genome...
  77. pmc Genotypic characterization of rotaviruses and prevalence of serotype-specific serum antibodies in children in Kuwait
    R W Marmash
    Department of Microbiology, Kuwait University, Kuwait
    Epidemiol Infect 135:1331-7. 2007
    ..The serotype information will contribute to the fund of knowledge on the world epidemiology of rotavirus serotypes and will predict the outcome of vaccination in Kuwait...
  78. pmc Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin
    Zuzana Berkova
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, 1200 Moursund Street, Houston, TX 77030 3404, USA
    J Virol 81:3545-53. 2007
    b>Rotavirus is a major cause of infantile gastroenteritis with a multifactorial pathogenesis...
  79. pmc Hsp70 negatively controls rotavirus protein bioavailability in caco-2 cells infected by the rotavirus RF strain
    Alexis H Broquet
    Universite Pierre et Marie Curie Paris 6, UMR S 538, Paris F 75012, France
    J Virol 81:1297-304. 2007
    ..We show here that upon rotavirus infection of intestinal cells, Hsp70 is indeed rapidly, specifically, and transiently induced...
  80. ncbi Shifts of rotavirus g and p types in Nicaragua--2001-2003
    Felix Espinoza
    Department of Microbiology, University of Leon, Leon, Nicaragua
    Pediatr Infect Dis J 25:1078-80. 2006
    The present study reports the diversity of rotavirus strains circulating in León, Nicaragua during three years...
  81. pmc Characterization of homologous and heterologous rotavirus-specific T-cell responses in infant and adult mice
    Maria C Jaimes
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    J Virol 79:4568-79. 2005
    During primary rotavirus (RV) infection, CD8+ T cells play an important role in viral clearance as well as providing partial protection against reinfection...
  82. pmc Rotavirus nonstructural glycoprotein NSP4 is secreted from the apical surfaces of polarized epithelial cells
    Andrea Bugarcic
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Virol 80:12343-9. 2006
    NSP4, a nonstructural glycoprotein encoded by rotavirus, is involved in the morphogenesis of virus particles in the endoplasmic reticulum of infected cells...
  83. pmc Molecular characterization of novel G5 bovine rotavirus strains
    Sung Hee Park
    Bio therapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, South Korea
    J Clin Microbiol 44:4101-12. 2006
    ..The rotavirus genome is composed of 11 segments of double-stranded RNA and can undergo genetic reassortment during mixed ..
  84. ncbi Serum IgA levels induced by rotavirus natural infection, but not following immunization with the RRV-TV vaccine (Rotashield), correlate with protection
    Rosabel González
    Instituto de Biomedicina Fuvesin, Sección de Investigación de Enfermedades Entéricas de la Infancia, Universidad Central de Venezuela, Ministerio de Salud y Desarrollo Social, Caracas, Venezuela
    J Med Virol 76:608-12. 2005
    To directly compare serum rotavirus specific IgA as a marker of protection in children vaccinated with the RRV-TV (Rotashield) vaccine and in naturally infected children, we studied pre-existing rotavirus IgA antibodies by ELISA assays ..
  85. ncbi Considerations for introduction of a rotavirus vaccine in Oman: rotavirus disease and economic burden
    S A Al Awaidy
    Departments of Communicable Disease Surveillance and Control, Cairo, Egypt
    J Infect Dis 200:S248-53. 2009
    b>Rotavirus is the most common cause of fatal childhood diarrhea worldwide. We provide the first estimates of the health care and economic burden of severe rotavirus disease in Oman...
  86. pmc Full-length, glycosylated NSP4 is localized to plasma membrane caveolae by a novel raft isolation technique
    Stephen M Storey
    Department of Pathobiology, TVMC, Texas A and M University, TAMU 4467, College Station, TX 77843 4467, USA
    J Virol 81:5472-83. 2007
    b>Rotavirus NSP4, initially characterized as an endoplasmic reticulum intracellular receptor, is a multifunctional viral enterotoxin that induces diarrhea in murine pups...
  87. pmc Bovine rotavirus nonstructural protein 4 produced by Lactococcus lactis is antigenic and immunogenic
    V Enouf
    , INRA, 78352 Jouy en Josas, France
    Appl Environ Microbiol 67:1423-8. 2001
    b>Rotavirus nonstructural protein 4 (NSP4) can induce diarrhea in mice. To get insight into the biological effects of NSP4, production of large quantities of this protein is necessary...
  88. ncbi Identification of viral agents causing diarrhea among children in the Eastern Center of Tunisia
    I Fodha
    Laboratory of bacteriology virology, University Hospital Sahloul, Sousse, Tunisia
    J Med Virol 78:1198-203. 2006
    ..All samples were tested for rotavirus, astrovirus, and adenovirus using commercial antigen enzyme immunoassays (EIAs)...
  89. ncbi Characterization of rotavirus strains detected among children and adults with acute gastroenteritis in Gizan, Saudi Arabia
    Ali M Kheyami
    Department of Medical Microbiology, The University of Liverpool, Duncan Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
    Saudi Med J 29:90-3. 2008
    To assess the circulating rotavirus strains among hospitalized children and adults in Gizan City.
  90. ncbi Incidence, characteristics, and economic burden of rotavirus gastroenteritis associated with hospitalization of israeli children <5 years of age, 2007-2008
    Khitam Muhsen
    Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Infect Dis 200:S254-63. 2009
    Limited data exist on the epidemiology and burden of rotavirus gastroenteritis in Israel. Objectives...
  91. ncbi Improved strategies for sequence-independent amplification and sequencing of viral double-stranded RNA genomes
    A C Potgieter
    OIE reference laboratories for African horsesickness and bluetongue, Virology Division, Onderstepoort Veterinary Institute, Private Bag X5, Onderstepoort 0110, South Africa
    J Gen Virol 90:1423-32. 2009
    ..of an African horsesickness virus (AHSV) genome determined directly from a blood sample and a complete human rotavirus genome determined from faeces...
  92. ncbi Possible mechanisms of protection elicited by candidate rotavirus vaccines as determined with the adult mouse model
    Richard L Ward
    Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Viral Immunol 16:17-24. 2003
    ..morbidity and mortality worldwide each year, supporting the need for a vaccine that is effective against rotavirus disease in all socioeconomic environments...
  93. ncbi Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens
    Margo C Honeyman
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 184:2204-10. 2010
    ..b>Rotavirus (RV) has been implicated in the pathogenesis of type 1 diabetes...
  94. ncbi Hospitalizations for nosocomial rotavirus gastroenteritis in a tertiary pediatric center: a 4-year prospective study
    Orith Waisbourd-Zinman
    Department of Pediatrics A, Schneider Children s Medical Center, Petach Tikva 49202, Israel
    Am J Infect Control 37:465-9. 2009
    Although rotavirus is the most common cause of gastroenteritis worldwide, data regarding nosocomial rotavirus gastroenteritis (NRVGE) are limited...
  95. ncbi Rotavirus gastroenteritis in children in 4 regions in Brazil: a hospital-based surveillance study
    Veridiana Munford
    Virology Laboratories, Department of Microbiology, Institute of Biomedical Sciences, MSD Brazil
    J Infect Dis 200:S106-13. 2009
    b>Rotavirus is a major cause of gastroenteritis in children. Knowledge of rotavirus genotypes is important for vaccination strategies.
  96. ncbi Electrophoretic RNA genomic profiles of rotavirus strains prevailing among hospitalized children with acute gastroenteritis in tehran, iran
    Shahrzad Modarres
    Department of Virology, Pasteur Institute of Iran, Tehran, Iran
    Arch Iran Med 11:526-31. 2008
    Human rotavirus has now been established as the most important cause of childhood gastroenteritis worldwide...
  97. ncbi Epidemiology of rotavirus diarrhoea in Iranian children
    B Khalili
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    J Med Virol 73:309-12. 2004
    Human rotavirus is the most important cause of severe diarrhoea in infants and young children worldwide. We describe the aetiology of viral diarrhoea and the characteristics of rotavirus infection in Shahrekord, Iran...
  98. ncbi Rotavirus epidemiology: the Asian Rotavirus Surveillance Network
    E A S Nelson
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Vaccine 26:3192-6. 2008
    Availability of new rotavirus vaccines has highlighted the need to collect local disease and economic burden data to aid decision makers at global, regional and country level...
  99. ncbi Group A rotavirus strains circulating in the eastern center of Tunisia during a ten-year period (1995-2004)
    A Chouikha
    Laboratory MDT 01, Faculty of Pharmacy, Monastir, Tunisia
    J Med Virol 79:1002-8. 2007
    An epidemiological survey investigating rotavirus infections in children was undertaken in the Eastern Center of Tunisia between January 1995 and December 2004...
  100. pmc Molecular epidemiology of rotavirus diarrhea among children in Saudi Arabia: first detection of G9 and G12 strains
    Ali M Kheyami
    Department of Medical Microbiology, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, United Kingdom
    J Clin Microbiol 46:1185-91. 2008
    In anticipation of rotavirus vaccine introduction in Saudi Arabia, this study was undertaken to determine the distribution of the G and P genotypes of rotaviruses in order to examine whether there was any emerging serotype or unusual ..
  101. pmc Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains
    Michelle M Arnold
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892 8026, USA
    J Virol 85:1970-9. 2011
    Studies involving limited numbers of rotavirus (RV) strains have shown that the viral gene 5 product, NSP1, can antagonize beta interferon (IFN-β) expression by inducing the degradation of IFN-regulatory factors (IRFs) (IRF3, IRF5, and ..

Research Grants77

  1. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    ..Thus it is important to understand how the innate antiviral response is triggered in rotavirus infected cells and what viral proteins function to modulate this first line of host defense...
  2. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Rotavirus (RV) causes diarrhea in infants worldwide with most deaths in Africa and Asia. Newly licensed oral RV vaccines have unproven or lower efficacies in infants in impoverished countries...
  3. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ..from prevalent respiratory and intestinal pathogens such as influenza, respiratory syncytical virus (RSV), rotavirus and numerous bacterial infections that pose substantial threats to world health...
  4. Breakthroughs to advance the in vitro propagation of human noroviruses
    Qiuhong Wang; Fiscal Year: 2010
    ..that adapt to cell culture, like we verified previously for in vitro adaptation of Gn pig-passaged human rotavirus. Medium supplements or conditions mimicking the intestinal microenvironment include intestinal content filtrates,..
  5. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ..It is uniquely restricted to the early neonatal period, and rotavirus (RRV) infection only causes BA in mice when injected during the first 3 days of life...
  6. The development of probiotic yeast as an inexpensive vaccine delivery platform
    TRACEY JANE LAMB; Fiscal Year: 2013
    ..Although vaccines currently exist to protect against infection with rotavirus and cholera, uptake of these vaccines in developing countries is poor due to the financial cost...
  7. Causes of rotavirus vaccine failure in Zambian children
    Roma Chilengi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite being vaccine preventable, rotavirus is the most important cause of severe gastroenteritis among children and kills half a million children each year worldwide...
  8. Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccines
    ANASTASIA NICKOLAEVNA VLASOVA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rotavirus (RV) is a leading global cause of childhood diarrhea...
  9. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    ..VHH fragments derived from llama heavy chain Abs as an alternative or complementary approach to vaccination for rotavirus (RV) diarrhea prevention and treatment...
  10. Lactogenic immunity/probiotics: Effect on neonatal gut immunity
    Linda J Saif; Fiscal Year: 2010
    ..b>Rotavirus (RV) is a leading cause of diarrhea in infants worldwide...
  11. Multiplexed Detection of Food and Waterborne Pathogens
    Francis Barany; Fiscal Year: 2011
    ..Entamoeba histolytica, Giardia lamblia and Microsporidia) and viruses (Caliciviruses, Hepatitis A virus and Rotavirus) respectively...
  12. Oligosaccharide moieties of human milk glycans that inhibit pathogens
    David S Newburg; Fiscal Year: 2013
    ..b>Rotavirus and HIV infections in infants are introduced primarily through oral inoculation, and we discovered that these ..
  13. Viral Gastroenteritis: Basis of Protection and Virulence
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rotavirus (RV) infection is the leading cause of childhood diarrheal morbidity and mortality worldwide despite the recent approval of two safe and effective live attenuated vaccines...
  14. Mechanisms of Immune Modulation by Probiotics
    Lijuan Yuan; Fiscal Year: 2012
    ..Lactobacillus strains demonstrated intrinsic adjuvanticity and enhanced antigen-specific immune responses to rotavirus infection and to viral and bacterial vaccines...
  15. T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    CARA LYNN MACK; Fiscal Year: 2011
    ..Due to the rarity of BA and the limited accessibility to human tissue, the Rhesus rotavirus (RRV)-induced murine model of BA will be utilized in these investigations...
  16. Enteric Virus Calcium Channel Inhibitors
    Joseph M Hyser; Fiscal Year: 2013
    ..of RV-infected enterocytes is the dramatic elevation in cytoplasmic calcium, which is triggered by the rotavirus nonstructural protein 4 (NSP4)...
  17. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    ..6% of deaths from enteric infection. Other important pathogens that invade the epithelium include rotavirus, Salmonella, Shigella, Yersinia, enteroinvasive E. coli, and Campylobacter...
  18. Norovirus P Particle, A Multifunctional Platform For Vaccine Development
    Ming Tan; Fiscal Year: 2012
    ..small epitopes and large antigens on one of these loops, including the M2e epitope of influenza virus and rotavirus (RV) surface antigen VP8s...
  19. DNA methylation in biliary development and disease
    Randolph P Matthews; Fiscal Year: 2013
    ..IFN3 levels are elevated in patients with BA, and targeted deletion of IFNg inhibits development of the rhesus rotavirus (RRV)-injected mouse model of BA...
  20. Rotavirus: Studies of Intestinal Tropism, Viral Entry, and Rescue
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..3) Develop a tractable reverse-genetics system to manipulate the genome of a replication competent rotavirus. In order to take RV pathogenesis and cell entry studies to the next level, methodologies to directly modify the ..
  21. Defining the cis and trans acting factors required for assembly of infectious Blu
    Polly Roy; Fiscal Year: 2013
    ..BTV and other members (rotavirus and reoviruses) are complex, multi-layered capsid viruses with 10-12 segmented double-stranded RNA genomes but ..
  22. Novel Mucosa-homing Dendritic Cell: Development, Trafficking and Function
    Eugene C Butcher; Fiscal Year: 2013
    ..g. for HIV or rotavirus) and to control pathologic inflammation (e.g. in inflammatory bowel diseases or celiac disease).
  23. Effect of Nutrition, Immunity, and Vaccines on Pediatric Enteric Infections
    Juan S Leon; Fiscal Year: 2013
    ..to optimize a population's natural and vaccine-acquired immunity to diarrhea-inducing enteric viruses like rotavirus (RV) and norovirus (NoV) and thereby protect children from diarrhea. ENVIRONMENT: Drs...
  24. Intestinal Lymphocyte Trafficking
    Eugene C Butcher; Fiscal Year: 2013
    ..and inflamed intestines may lead to novel therapeutic approaches in IBD, as well as providing insights that can improve methods of vaccination and monitoring of mucosal immunity to HIV, SARS, rotavirus and other infectious agents.
  25. INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    MARTIN FREDERICK KAGNOFF; Fiscal Year: 2013
    ..Unit 1 uses an attaching and effacing lesion-inducing enteric pathogen and rotavirus to probe the host response, and the mechanisms by which granulocyte-macrophage colony stimulating factor ..
  26. The Molecular Structure of the RNA Polymerase Portal of a Bacteriophage-Reovirus
    PAUL JEFFREY GOTTLIEB; Fiscal Year: 2013
    ..is of critical importance in the design of antiviral pharmaceuticals for pathogenic reoviruses, in particular rotavirus, a significant cause of childhood morbidity in third world countries...
  27. Childhood Liver Disease Research and Education Network (CHiLDREN) - UCSF (CC)
    Philip Rosenthal; Fiscal Year: 2013
    ..Cara Mack at the University of Colarado. Further, in order to determine if rotavirus plays an etiologic role in biliary atresia, we plan to compare data from the former BARC database and new ..
  28. Enhanced Surveillance for New Vaccine Preventable Diseases
    Mary A Staat; Fiscal Year: 2010
    ..Ohio for acute respiratory infections and acute gastroenteritis to better understand the burden of influenza and rotavirus and to conduct applied epidemiologic studies to examine the impact of influenza and rotavirus vaccines in our ..
  29. Intracellular Calcium Regulated NHE3 Endocytosis
    NICHOLAS CONSTANTINE ZACHOS; Fiscal Year: 2012
    ..g. rotavirus infection)...
  30. STRUCTURE AND ASSEMBLY OF VIRUSES
    STEPHEN COPLAN HARRISON; Fiscal Year: 2012
    ..x-ray crystallography with electron cryo-microscopy (cryoEM) to analyze the organization of reovirus and rotavirus particles and to study the conformational changes in their penetration proteins (u1 and VP5*, respectively) that ..
  31. Control of Viral Pathogenesis by Regulation of 2-5A Levels
    Susan R Weiss; Fiscal Year: 2013
    ..The ns2 protein and related viral (rotavirus VP3) and mammalian (AKAP7) proteins are 2H phosphoesterases with 2',5'-phosphodiesterase (PDE) ..
  32. Isolation, Identification and Characterization of a Toxin Causing Biliary Atresia
    Rebecca G Wells; Fiscal Year: 2013
    ..are limited, and the best-known animal model of the disease, the infection of newborn BALB/c mice with rhesus rotavirus (RRV), has provided important information about immunological aspects of the disease but has been less useful ..
  33. Regulation of Rotavirus Replication
    MARY KOLB ESTES; Fiscal Year: 2013
    ..The central hypothesis of our proposed research is that NSP4 is a key regulator of rotavirus replication and morphogenesis...
  34. Vaccinology in the Tropics: Vaccines in a Globalized World Conference
    ARLENE ESTELLA CALVO; Fiscal Year: 2012
    ..Some vaccines such as HPV, Rotavirus, and pandemic influenza, have been incorporated into the national immunization programs of underserved ..
  35. Enhanced Surveillance for New Vaccine Preventable Diseases
    Rangaraj Selvarangan; Fiscal Year: 2013
    ..Our two model projects are described below: First model project: Our first model project will examine rotavirus vaccination effectiveness through population-based, laboratory confirmed, active surveillance...
  36. Epitope shifting and Antibody Maturation during Rotavirus Infection
    Benjamin W Spiller; Fiscal Year: 2012
    ..We will focus anti-rotavirus VP6 antibodies that use the VH1-46 gene segment...
  37. Infectious Diseases and Child Health in Pakistan Research Training Program.
    Anita K M Zaidi; Fiscal Year: 2013
    ..training areas will include: polio eradication, sustainable introduction of new vaccines against diarrhea (rotavirus vaccine) and pneumonia (pneumococcal vaccines), measles elimination, optimizing immunization programs;and ..
  38. A broadly protective vaccine for enterotoxigenic Escherichia coli (ETEC)
    David A Sack; Fiscal Year: 2013
    ..Results from this study will lead toward development of an affordable vaccine for ETEC diarrhea with potential to save thousands of children each year -- with a public health impact comparable to rotavirus vaccine.
  39. Prediction of influenza antigenic variants using a novel sparse multitask learnin
    Xiu Feng Wan; Fiscal Year: 2010
    ..in characterizing antigenic properties of other pathogens with significant antigenic variations, for example, rotavirus. The specific aims are the following: (1) Development of a novel sparse multitask learning method in generating ..
  40. HIV-1 and Protective Immunity against Common Childhood Pathogens
    Carey Farquhar; Fiscal Year: 2013
    ..Antiretroviral Therapy during Pregnancy and Breastfeeding on Passive Transfer of Antibodies against Measles, Rotavirus, and Pneumococcus," utilizes data from an existing randomized clinical trial and investigates non-HIV causes of ..
  41. Mechanisms by which Human Milk Oligosaccharides Protect Against Rotavirus
    SHARON MARIE DONOVAN; Fiscal Year: 2012
    ..PDX/GOS) influence activation of dendritic cells (DC) and lymphocyte responses to vaccination against rotavirus (RV) and a subsequent RV challenge in the piglet model...
  42. Intestinal and Milk Glycan Expression in Restriction of Neonatal Infection
    MARY KOLB ESTES; Fiscal Year: 2013
    ..Characterization of a rotavirus strain that almost exclusively infects neonates in India and new data that human rotaviruses can initiate ..
  43. Rotavirus VP6 Specific Human IgA Antibodies
    James E Crowe; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mechanisms of immunity to rotavirus, the major cause of dehydrating diarrhea in children, have proven elusive...
  44. MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDREN
    MICHAEL BENNISH; Fiscal Year: 2002
    ..coli (determined using probes for virulence genes), rotavirus, enteric adenoviruses 40/41, astroviruses and Norwalk virus, and the protozoan pathogens C...
  45. Effect of tissue tropism on RNA viral evolutionary rates: three family-level anal
    SIOBAIN MARIE DEIRDRE DUFFY; Fiscal Year: 2012
    ..of foodborne illness in this country, Picornaviridae, which include poliovirus, and Reoviridae, which include rotavirus, the most common cause of infant diarrhea worldwide...
  46. Reassessing the Physiological Role of Gut-Specific Lymphocyte Homing: Implication
    Jorge Mora; Fiscal Year: 2009
    ..It would also offer a simple method for boosting intestinal immune responses for vaccination purposes, such as in infections by Salmonella, rotavirus, and HIV.
  47. Studies on Emergent Diarrheagenic E. coli Pathogens
    OSCAR GOMEZ; Fiscal Year: 2013
    ..E. coli pathogens are believed to be the second most common cause of death after Rotavirus. Six categories of diarrheagenic E...
  48. MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDREN
    Sherwood Gorbach; Fiscal Year: 2005
    ..coli (determined using probes for virulence genes), rotavirus, enteric adenoviruses 40/41, astroviruses and Norwalk virus, and the protozoan pathogens C...
  49. STRUCTURE AND ASSEMBLY OF VIRUSES
    STEPHEN COPLAN HARRISON; Fiscal Year: 2013
    ..1) Non- enveloped viral entry. We can follow rotavirus entry by live-cell fluorescence microscopy with particles bearing spectrally distinct labels on VP4 (the ..
  50. Probiotics to Enhance Influenza Vaccine Immunogenicity
    Patricia L Hibberd; Fiscal Year: 2013
    ..suggest that LGG boosts the immune response to mucosally administered vaccines such as oral Salmonella typhi, rotavirus and polio virus...
  51. The Molecular Determinants of Virus Induced Biliary Atresia
    Gregory M Tiao; Fiscal Year: 2013
    ..The murine model of biliary atresia supports a viral pathogenesis as newborn mice infected with rhesus rotavirus (RRV) develop inflammation within the portal tract and extra- hepatic bile duct obstruction...
  52. Molecular Epidemiology and Key Issues of Foodborne Pathogens in Eastern Africa
    Samuel M Kariuki; Fiscal Year: 2013
    ..will have access to multitudes of opportunities at OSU leveraged with well-funded research areas including rotavirus, salmonellosis, tuberculosis and E. coli 0157:H7...
  53. Human Intestinal Organoids: Pre-Clinical Models of Non-Inflammatory Diarrhea
    Mark Donowitz; Fiscal Year: 2013
    ..and Cl secretion to increase understanding of three important human diarrheal diseases caused by cholera toxin, rotavirus and enterohemorrhagic E. coli...
  54. Enhanced Surveillance for New Vaccine Preventable Disease
    Peter G Szilagyi; Fiscal Year: 2013
    ..Our proposal focuses activities on acute gastroenteritis (AGE) in young children (rotavirus, norovirus), but has equal strength in studying a variety of acute respiratory infections (ARIs)...
  55. Enhanced Surveillance for New Vaccine Preventable Disease
    Mary A Staat; Fiscal Year: 2013
    ..The major focus will be to describe the burden and epidemiology of rotavirus infection resulting in hospitalization and ED visits between 15 days and 11 years of age using active ..
  56. Shrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)
    Michelle Khine; Fiscal Year: 2013
    ..The goal of this proposal is to develop and deploy my chips for the detection of the infectious and deadly rotavirus disease...
  57. ENHANCING THE IMMUNOGENICITY OF HUMAN ROTAVIRUS VACCINES
    Linda Saif; Fiscal Year: 2006
    ..abstract_text> ..
  58. ATOMIC RESOLUTION IN BIOLOGICAL ELECTRON MICROSCOPY
    STEPHEN COPLAN HARRISON; Fiscal Year: 2013
    ..b>Rotavirus entry and clathrin-coat dynamics are two specific projects for which structures determined as part of this ..
  59. The Johns Hopkins Pediatric Liver Center ChiLDREN Grant
    Kathleen Schwarz; Fiscal Year: 2013
    ..2) Expand our ongoing study of the Role of Rotavirus in "Human Biliary Atresia";this is a study in which we are investigating sera from BA and genetic cholestatic ..
  60. Immune responses to Norovirus after natural infection in Vietnamese children and
    Xi Jiang; Fiscal Year: 2013
    ..Our goal is to have the LMIC laboratory becoming a national reference laboratory and Dr. Trang the national leader in the NV and rotavirus researches in Vietnam.
  61. Enhanced Surveillance-Newly Vaccine Preventable Diseases
    Peter G Szilagyi; Fiscal Year: 2010
    ..potential burden of rotavirus disease to prepare for population- based laboratory surveillance for soon anticipated new vaccines (dataset ..
  62. Preliminary Effectiveness Analysis of Universal Rotavirus Immunization, Nicaragua
    SYLVIA IRENE BECKER-DREPS; Fiscal Year: 2012
    ..acquire expertise in infectious disease epidemiology and vaccine effectiveness;to assess the effectiveness ofthe rotavirus vaccine in a developing world setting...
  63. VIRAL PROTEINS IN ROTAVIRUS REPLICATION
    John Patton; Fiscal Year: 1991
    ..To understand the mechanism of rotavirus RNA replication, we developed a cell-free system that supports the synthesis of simian rotavirus SAll dsRNA, ..
  64. Enhanced Surveillance for New Vaccine Preventable Disease
    Janet A Englund; Fiscal Year: 2013
    ..within the national surveillance effort, capturing data from a part of the country with differences in both rotavirus seasonality and immunization rates for rotavirus vaccine. The Seattle investigators, led by Drs...
  65. ENTERIC VIRAL INFECTIONS OF CAPTIVE RHESUS MACAQUES
    Karol Sestak; Fiscal Year: 2009
    ..Globally, each year 352,000-592,000 deaths in children less than 5 years of age can be linked to rotavirus infection...
  66. INDO-US Collaboration to Develop Rotavirus Vaccines
    Pratima Ray; Fiscal Year: 2005
    b>Rotavirus infects all children by 5 years of life, and is the most common cause of severe gastroenteritis worldwide. In the US, rotavirus is a common cause of morbidity, accounting for considerable health-care costs...
  67. Probiotics for Infectious Diarrhea in Children in South India
    Honorine Ward; Fiscal Year: 2009
    ..b>Rotavirus and Cryptosporidium spp...
  68. Effects of Probiotic Lactobacilli on Rotavirus Immunity
    Lijuan Yuan; Fiscal Year: 2006
    ..Probiotics, such as Lactobacilli have been shown to reduce the severity of rotavirus diarrhea; however the immunologic mechanisms have not been clearly defined...
  69. VIRAL GASTROENTERITIS--BASIS OF PROTECTION AND VIRULENCE
    Harry Greenberg; Fiscal Year: 2003
    ..Despite substantial progress over the past two decades in determining rotavirus gene structure and function, we still do not have a clear understanding of the basis of rotavirus immunity, ..
  70. Cell Entry of Human Metapneumovirus
    John Williams; Fiscal Year: 2009
    ..utilize RGD-binding integrins as receptors or co-receptors, including adenovirus, Coxsackievirus, parechovirus, rotavirus and human herpes virus-8...
  71. In Vivo Antiviral Activity of Saponins
    MICHAEL RONER; Fiscal Year: 2007
    ..We will use a mouse model of rotavirus induced diarrhea to test this hypothesis...
  72. SURFACE MEMBRANES IN NORMAL AND CANCER CELLS
    Paul Atkinson; Fiscal Year: 1991
    ..We will use rotavirus as a model system, since it buds into the RER, where glycoproteins it encodes are specifically located...
  73. Mechanistic Studies at the Host-pathogen Interface
    David McMurray; Fiscal Year: 2007
    ..Mycobacterium tuberculosis, Brucella abortus, Bartonella species, influenza virus, Borrelia burgdorferi, rotavirus, Coxiella burnetii, and hepatitis virus...
  74. BIOMEDICAL RESEARCH SUPPORT
    HENRYK WISNIEWSKI; Fiscal Year: 1991
    ..Eskin (endothelial cell shear stress induced proteins); M. Estes (rotavirus proteins); S. Hamilton (calcium channel proteins from muscle); F...
  75. DEVELOPMENT OF ROTAVIRUS DNA VACCINES
    John Herrmann; Fiscal Year: 2003
    DESCRIPTION: (Adapted from Applicant's Abstract) The goal of our studies is to develop and test rotavirus DNA vaccines in mice and gnotobiotic pigs that will provide the basis for development of human rotavirus DNA vaccines...
  76. IMMUNE RESPONSES TO ROTAVIRUS-- ROLE MATERNAL ANTIBODIES
    Linda Saif; Fiscal Year: 2003
    ..investigated, using as a model HRV and the following approaches: 1) Intranasal (IN) delivery of non-replicating rotavirus-like-particles (VLP) will be used to analyze the effects of maternal Ab and T cell responses and cytotoxic ..
  77. HEPATITIS A AND GASTROENTERITIS VIRUSES IN MARINE LIFE
    Charles Gerba; Fiscal Year: 1980
    We propose to develop methodology for detecting and concentrating hepatitis virus type A (HAV) and human rotavirus (infantile gastroenteritis virus) from potable water, sewage and shellfish...