Genomes and Genes
influenza b virus
Summary: Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.
Publications343 found, 100 shown here
- Mortality associated with influenza and respiratory syncytial virus in the United StatesWilliam W Thompson
Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 289:179-86. 2003..Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have not accounted for RSV circulation...
- Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010Anthony E Fiore
Influenza Division, National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Road, N E, MS A 20, Atlanta, GA 30333, USA
MMWR Recomm Rep 59:1-62. 2010..Vaccination and health-care providers should be alert to announcements of recommendation updates and should check the CDC influenza website periodically for additional information...
- Influenza-associated hospitalizations in the United StatesWilliam W Thompson
Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 292:1333-40. 2004..Respiratory viral infections are responsible for a large number of hospitalizations in the United States each year...
- The need for quadrivalent vaccine against seasonal influenzaRobert B Belshe
Saint Louis University School of Medicine, USA
Vaccine 28:D45-53. 2010..and little or no protection has been provided in the USA by the trivalent vaccines against the circulating influenza B virus in 5 of the 10 seasons between 2001 and 2010...
- Molecular studies of influenza B virus in the reverse genetics eraDavid Jackson
Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
J Gen Virol 92:1-17. 2011..In 2002, two groups reported the successful recovery of influenza B virus entirely from cDNA. This has allowed greater depth of study into the biology of these viruses...
- Ecological and immunological determinants of influenza evolutionNeil M Ferguson
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Nature 422:428-33. 2003....
- Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarityRobert B Belshe
Saint Louis University Health Science Center, St Louis, MO 63104, USA
Vaccine 28:2149-56. 2010....
- The evolutionary dynamics of human influenza B virusRubing Chen
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA
J Mol Evol 66:655-63. 2008..However, it is unclear what processes determine the evolutionary dynamics of influenza B virus, and how influenza viruses A and B interact at the evolutionary scale...
- Evaluation of three influenza A and B real-time reverse transcription-PCR assays and a new 2009 H1N1 assay for detection of influenza virusesSuresh B Selvaraju
Department of Pathology and Laboratory Medicine, Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, Missouri 64108, USA
J Clin Microbiol 48:3870-5. 2010..specimens from children (30 influenza A/H1 virus-, 30 influenza A/H3 virus-, 30 2009 H1N1-, and 30 influenza B virus-positive specimens and 30 influenza virus-negative specimens) were tested with the CDC influenza A/B PCR (..
- Unexpected severity of cases of influenza B infection in patients that required hospitalization during the first postpandemic waveA Gutiérrez-Pizarraya
Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBIS, University Hospital Virgen del Rocío CSIC University of Seville, Seville, Spain
J Infect 65:423-30. 2012..The aim of this study was to compare the features of influenza B versus influenza A(H1N1)pdm09 infections during the 2010-2011 epidemic-season...
- Effectiveness of influenza vaccine in health care professionals: a randomized trialJ A Wilde
Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Childrens Hospital, Cleveland, Ohio, USA
JAMA 281:908-13. 1999..Data are limited and conflicting regarding the effectiveness of influenza vaccine in health care professionals...
- Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurementC L Ward
International Clinical Virology, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK
J Clin Virol 29:179-88. 2004..Historically this was measured using plaque assays, or Culture Enhanced Enzyme Linked Immunosorbent Assay (CE-ELISA)...
- Clinical manifestations and socio-economic impact of influenza among healthy children in the communitySusanna Esposito
Department of Maternal and Paediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
J Infect 62:379-87. 2011..To evaluate the total burden of influenza among healthy children in the community in order to analyse the cost of influenza in paediatric age...
- Public health impact of including two lineages of influenza B in a quadrivalent seasonal influenza vaccineCarrie Reed
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, United States
Vaccine 30:1993-8. 2012..One proposed alternative is to produce a quadrivalent influenza vaccine (QIV) including an influenza B virus from each of the two circulating lineages...
- Challenge of conducting a placebo-controlled randomized efficacy study for influenza vaccine in a season with low attack rate and a mismatched vaccine B strain: a concrete exampleJiri Beran
The Vaccination and Travel Medicine Center, Hradec Kralove, Czech Republic
BMC Infect Dis 9:2. 2009..Our aim was to determine the efficacy of a trivalent inactivated split virus influenza vaccine (TIV) against culture-confirmed influenza A and/or B in adults 18 to 64 years of age during the 2005/2006 season in the Czech Republic...
- Epidemiological, antigenic and genetic characteristics of seasonal influenza A(H1N1), A(H3N2) and B influenza viruses: basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009-2010 northern hemisphere seasonIan G Barr
WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Melbourne, Australia
Vaccine 28:1156-67. 2010..This article gives a summary of the data and background to the recommendations for the 2009-2010 Northern Hemisphere influenza vaccine formulation...
- Estimating vaccine effectiveness against laboratory-confirmed influenza using a sentinel physician network: results from the 2005-2006 season of dual A and B vaccine mismatch in CanadaD M Skowronski
Epidemiology Services, BC Centre for Disease Control, Canada
Vaccine 25:2842-51. 2007....
- Qualitative and quantitative analyses of virtually all subtypes of influenza A and B viral neuraminidases using antibodies targeting the universally conserved sequencesCaroline Gravel
Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada
Vaccine 28:5774-84. 2010..The reasons for the absence or low level of neuraminidase in vaccine preparations are complex and could be multi-factorial. The antibody-based assays reported here could be of practical value for better vaccine quality control...
- Clinical features of influenza A and B in children and association with myositisJen Jan Hu
Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan, ROC
J Microbiol Immunol Infect 37:95-8. 2004..Influenza A virus outbreaks occurred in January 2000, July 2001, and December 2001, while influenza B virus outbreaks occurred from March 2000 to May 2000 and from December 2000 to February 2001...
- Structural basis for receptor specificity of influenza B virus hemagglutininQinghua Wang
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 104:16874-9. 2007..Here we report the structures of influenza B virus HA in complex with human and avian receptor analogs, respectively...
- Crystal structure of unliganded influenza B virus hemagglutininQinghua Wang
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, BCM 125, Houston, TX 77030, USA
J Virol 82:3011-20. 2008..More than two dozen amino acid substitutions on influenza B virus HAs have been identified to cause antigenicity alteration in site-specific mutants, monoclonal antibody ..
- Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003-2004Dorothy L Moore
Infectious Diseases Division, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Pediatrics 118:e610-9. 2006....
- Reappearance and global spread of variants of influenza B/Victoria/2/87 lineage viruses in the 2000-2001 and 2001-2002 seasonsMichael W Shaw
National Microbiology Laboratory, Canadian Science Center for Human and Animal Health, Winnipeg, Manitoba, R3E 3R2, Canada
Virology 303:1-8. 2002....
- Synchrony, waves, and spatial hierarchies in the spread of influenzaCecile Viboud
Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
Science 312:447-51. 2006..A simple epidemiological model, based on the gravity formulation, captures the observed increase of influenza spatial synchrony with transmissibility; high transmission allows influenza to spread rapidly beyond local spatial constraints...
- Duration of protection provided by live attenuated influenza vaccine in childrenChristopher S Ambrose
MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
Pediatr Infect Dis J 27:744-8. 2008..Reliable availability of influenza vaccine before October could enable the vaccination of many children who might not otherwise be vaccinated...
- InfluenzaKarl G Nicholson
Infectious Diseases Unit, Leicester Royal Infirmary, Leicester, UK
Lancet 362:1733-45. 2003....
- Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in childrenNorio Sugaya
Department of Pediatrics, Keiyu Hospital, Yokohama, Kanagawa, 220 0012, Japan
Clin Infect Dis 44:197-202. 2007Recently, many Japanese physicians have claimed that oseltamivir is less effective in children with influenza B virus infection...
- Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infectionCaroline Lai
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Virol 83:1147-51. 2009..Both UbE1L(-/-) and ISG15(-/-) mice display increased susceptibility to influenza B virus infection, including non-mouse-adapted strains...
- Influenza B virus NS1-truncated mutants: live-attenuated vaccine approachRong Hai
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Virol 82:10580-90. 2008..We also provide evidence that influenza B virus NS1 mutants induce a self-adjuvanted immune response and confer effective protection against challenge with ..
- A comparison of the effectiveness of oseltamivir for the treatment of influenza A and influenza B: a Japanese multicenter study of the 2003-2004 and 2004-2005 influenza seasonsNaoki Kawai
Japan Physicians Association, Tokyo, Japan
Clin Infect Dis 43:439-44. 2006..The study included 3351 patients in whom influenza had been diagnosed by use of an antigen detection test kit...
- Species-specific antagonism of host ISGylation by the influenza B virus NS1 proteinGijs A Versteeg
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Virol 84:5423-30. 2010..Furthermore, we demonstrate that influenza B virus NS1 protein potently antagonizes human but not mouse ISGylation, a property dependent on B/NS1 binding the N-..
- Multiplex real-time PCR assay for detection of influenza and human respiratory syncytial virusesGuy Boivin
Research Center in Infectious Diseases of the CHUQ CHUL, Department of Pediatrics, Laval University, Quebec City, Canada
J Clin Microbiol 42:45-51. 2004..8%) of 208 cases, including 45 (21.6%) influenza A virus infections, no (0%) influenza B virus infections, 106 (51%) HRSV infections, and 12 (5.8%) coinfections...
- Multiple genotypes of influenza B virus circulated between 1979 and 2003Jonathan A McCullers
Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
J Virol 78:12817-28. 2004The segmented genome of influenza B virus allows exchange of gene segments between cocirculating strains...
- Cocirculation and evolution of two lineages of influenza B viruses in europe and Israel in the 2001-2002 seasonX Sherry Chi
Clinical Immunology and Virology Department, Applied Immunology and Microbiology Division, Wyeth Vaccine Research, Pearl River, New York 10965, USA
J Clin Microbiol 41:5770-3. 2003Forty-nine influenza B virus isolates collected in Belgium, Finland, Spain, and Israel during the 2001-2002 winter season were categorized into either of two lineages, B/Yamagata/16/88 or B/Victoria/2/87, based on the phylogenetic ..
- Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their useArnold S Monto
University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Antimicrob Agents Chemother 50:2395-402. 2006..The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use...
- Differences in clinical features between influenza A H1N1, A H3N2, and B in adult patientsMasahide Kaji
Kurume University Medical Center, Department of Internal Medicine, Japan
Respirology 8:231-3. 2003..The differences in clinical features between influenza A H1N1, A H3N2, and B in the past three influenza seasons were examined...
- Comparative efficacy of inactivated and live attenuated influenza vaccinesArnold S Monto
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
N Engl J Med 361:1260-7. 2009..The efficacy of influenza vaccines may vary from year to year, depending on a variety of factors, and may differ for inactivated and live attenuated vaccines...
- Phylogenetic and evolutionary history of influenza B viruses, which caused a large epidemic in 2011-2012, TaiwanJi Rong Yang
Centers for Disease Control, Taipei, Taiwan, Republic of China
PLoS ONE 7:e47179. 2012..The TW08-I viruses isolated in both 2011-2012 and 2007-2009 were antigenically similar, indicating that an influenza B virus have persisted for 5 years in antigenic stasis before causing a large epidemic...
- Respiratory tract viral infections in bone marrow transplant patientsSonia M Raboni
Laboratory of Virology, Hospital de Clinicas da Universidade Federal do Parana, Brazil
Transplantation 76:142-6. 2003..Community respiratory viruses such as respiratory syncytial virus (RSV), adenovirus, influenza A, influenza B, and the parainfluenza group are frequent causes of respiratory disease in bone marrow transplant (BMT) patients...
- Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in TaiwanWen Chen Li
Division of Pediatric Infectious Diseases, Chang Gung Children s Hospital, Taoyuan, Taiwan
J Clin Virol 42:45-51. 2008..Mismatches between circulating and vaccine strains of influenza virus had been observed in Taiwan. A comprehensive clinical and genetic analysis of influenza B viruses-associated important diseases was lacking...
- A human CD4+ T cell epitope in the influenza hemagglutinin is cross-reactive to influenza A virus subtypes and to influenza B virusJenny Aurielle B Babon
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Virol 86:9233-43. 2012..epitope is well conserved in all 16 subtypes of the HA protein of influenza A virus and the HA protein of influenza B virus. By stimulating peripheral blood mononuclear cells (PBMCs) from a healthy adult donor with peptides covering ..
- Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoproteinAndy Ka Leung Ng
Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China
J Virol 86:6758-67. 2012..We have determined the crystal structure of influenza B virus NP to a resolution of 3.2 Å. Influenza B NP contains a head, a body domain, and a tail loop...
- Influenza B and C virus NEP (NS2) proteins possess nuclear export activitiesJ Paragas
Department of Microbiology, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
J Virol 75:7375-83. 2001..VLPs generated in the absence of the influenza B virus NEP protein were unable to transfer the viral RNA-like CAT gene to a new cell...
- Serum antibodies against circulating influenza strains among vaccinated and unvaccinated general practitioners during two consecutive years (2002-2003)Barbara Michiels
Centre for General Practice, University of Antwerp Campus Drie Eiken, Universiteitsplein 1, 2610 Wilrijk Antwerpen, Belgium
Vaccine 24:3145-52. 2006..Besides vaccination, the (high) basic antibody titre before vaccination and working in a child and family preventive medicine unit were predicting a protective antibody level in GPs...
- Influenza Β/Victoria antigen induces strong recall of Β/Yamagata but lower Β/Victoria response in children primed with two doses of Β/YamagataDanuta M Skowronski
British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
Pediatr Infect Dis J 30:833-9. 2011..Trivalent inactivated influenza vaccine (TIV) contains 1 of 2 influenza B/lineages (B/Yamagata or B/Victoria) annually. We assessed prime-boost responses in young children following a change in the B/lineage included in TIV...
- Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virusRongjin Guan
Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway NJ 08854, USA
Proc Natl Acad Sci U S A 108:13468-73. 2011..The NS1 protein of influenza B virus (NS1B) specifically binds only human and nonhuman primate ISG15s and inhibits their conjugation...
- Defective interfering influenza A virus protects in vivo against disease caused by a heterologous influenza B virusPaul D Scott
School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
J Gen Virol 92:2122-32. 2011..In the current study, it was shown that 244/PR8 also protects against disease caused by a heterologous influenza B virus (B/Lee/40)...
- Influenza A and B virus infections in childrenVille Peltola
Department of Pediatrics, Turku University Hospital, Turku, Finland
Clin Infect Dis 36:299-305. 2003..Laboratory confirmation of influenza is particularly important for children because the clinical presentation of the infection is less characteristic than that seen in adults...
- Decreased leukocytes and other characteristics of laboratory findings of influenza virus infections in childrenChing Fen Shen
Department of Pediatrics, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
J Microbiol Immunol Infect 41:294-300. 2008..An outbreak of influenza A and influenza B appeared at the beginning and end of 2006 in southern Taiwan. We conducted this study to test whether laboratory findings could differentiate influenza A from influenza B infection...
- Impact of influenza vaccination on seasonal mortality in the US elderly populationLone Simonsen
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 6613, USA
Arch Intern Med 165:265-72. 2005..We tried to reconcile these conflicting findings by adjusting excess mortality estimates for aging and increased circulation of influenza A(H3N2) viruses...
- Influenza virus susceptibility and resistance to oseltamivirFred Y Aoki
Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
Antivir Ther 12:603-16. 2007..However, continued vigilance, especially of emerging avian H5N1 strains, combined with careful, systematic laboratory-based monitoring, is essential...
- Prevalence of antibodies against seasonal influenza A and B viruses in children in NetherlandsR Bodewes
Department of Virology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, Netherlands
Clin Vaccine Immunol 18:469-76. 2011..These findings may have implications for the development of vaccination strategies aiming at the protection of young children against seasonal and/or pandemic influenza virus infection...
- Performance of Directigen flu A+B enzyme immunoassay and direct fluorescent assay for detection of influenza infection during the 2004-2005 seasonMahbubur Rahman
Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Diagn Microbiol Infect Dis 58:413-8. 2007..Compared with culture, specificity of both EIA and DFA was 96%. During the 2004-2005 influenza season, both the EIA and DFA had low sensitivity and failed to detect influenza in many patients...
- High proportion of influenza B characterises the 2008 influenza season in VictoriaKristina A Grant
Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria
Commun Dis Intell Q Rep 33:328-36. 2009..Overall 56% of notifications of laboratory confirmed influenza to DHS and 56% of influenza positive swabs from sentinel surveillance were influenza type B...
- Outcome of influenza infections in outpatients after allogeneic hematopoietic stem cell transplantationN Khanna
Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
Transpl Infect Dis 11:100-5. 2009..Influenza can cause significant morbidity and mortality in patients after hematopoietic stem cell transplantation (HSCT). The diagnostic methods and antiviral treatment have scarcely been investigated...
- Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutininsStella Chun
Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, Ontario, Canada
Vaccine 26:6068-76. 2008..To our knowledge, this is the first report on the quantitative determination of virtually all influenza vaccines using a single universal antibody...
- Effect of influenza vaccination of children on infection rates in Hutterite communities: a randomized trialMark Loeb
Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St W, Hamilton, ON, L8N 3Z5 Canada
JAMA 303:943-50. 2010..Children and adolescents appear to play an important role in the transmission of influenza. Selectively vaccinating youngsters against influenza may interrupt virus transmission and protect those not immunized...
- Monitoring the impact of influenza by age: emergency department fever and respiratory complaint surveillance in New York CityDonald R Olson
New York City Department of Health and Mental Hygiene, New York, New York, United States of America
PLoS Med 4:e247. 2007..The purpose of this study was to evaluate the use of emergency department (ED) chief complaint data for measuring influenza-attributable morbidity by age and by predominant circulating virus...
- Influenza B virus evolution: co-circulating lineages and comparison of evolutionary pattern with those of influenza A and C virusesM Yamashita
Department of Microbiology, Mount Sinai School of Medicine, City University of New York, New York 10029
Virology 163:112-22. 1988..Examination of 14 influenza B virus NS gene and 10 HA gene sequences by the maximum parsimony method suggested that--as with influenza C viruses-..
- Multipathogen infections in hospitalized children with acute respiratory infectionsDan Peng
Pediatrics Department, Zhongnan Hospital, Wuhan University, Wuhan 430071, PR China
Virol J 6:155. 2009..A medical history of each child was taken...
- Long time trends in influenza-like illness and associated determinants in The NetherlandsF Dijkstra
National Institute for Public Health and the Environment, Epidemiology and Surveillance Unit, Bilthoven, The Netherlands
Epidemiol Infect 137:473-9. 2009..However, insufficient data were present to assess the impact of other potential contributing factors, such as diminished fitness of influenza viruses and changes in consulting behaviour...
- Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 proteinW Yuan
Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 78712, USA
EMBO J 20:362-71. 2001..We demonstrate the novel way in which the function of the ISG15 protein is inhibited by influenza B virus, which strongly induces the ISG15 protein: a specific region of the influenza B virus NS1 protein, which ..
- Diagnosis of influenza in the community: relationship of clinical diagnosis to confirmed virological, serologic, or molecular detection of influenzaM Zambon
Influenza Unit, Enteric and Respiratory Virus Laboratory, Central Public Health Laboratory, 61 Colindale Ave, Colindale, London NW9 5HT, England
Arch Intern Med 161:2116-22. 2001..Successful treatment of influenza depends on an accurate diagnosis of the illness and prompt intervention. However, there is a lack of data comparing clinical diagnosis vs laboratory diagnostic techniques...
- Synthetic multi-epitope peptides identified in silico induce protective immunity against multiple influenza serotypesGregory A Stoloff
PepTcell Limited, High Wycombe, UK
Eur J Immunol 37:2441-9. 2007..Overall, FLU-v represents a promising influenza vaccine candidate, obviating the need for yearly vaccinations and allowing the stockpiling and initiation of a worldwide vaccination program in advance of a pandemic outbreak...
- Safety and immunogenicity of a trivalent single dose seasonal influenza vaccine containing pandemic A(H1N1) antigen in younger and elderly subjects: a phase III open-label single-arm studyM Loebermann
University of Rostock, Department of Tropical Medicine and Infectious Diseases, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
Vaccine 29:1228-34. 2011..We investigated the immunogenicity and safety of a preservative-free non-adjuvanted seasonal trivalent influenza vaccine...
- Medically attended pediatric influenza during the resurgence of the Victoria lineage of influenza B virusLadonna K Hite
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Int J Infect Dis 11:40-7. 2007..During the 2002-2003 season, a new variant of influenza B co-circulated with influenza A viruses. This study examines the characteristics and outcomes of children with influenza A and B virus infection vs. other acute respiratory illnesses...
- Genetic diversity of influenza B virus: the frequent reassortment and cocirculation of the genetically distinct reassortant viruses in a communityYoko Matsuzaki
Department of Bacteriology, Yamagata University School of Medicine, Iida Nishi, Yamagata, Japan
J Med Virol 74:132-40. 2004..B viruses isolated during one influenza season, the antigenic and genetic relationships among 20 strains of influenza B virus isolated in February and March 2001 at one pediatric clinic in Yamagata City, Japan, were investigated...
- Clinical features of children infected with different strains of influenza B in southern TaiwanChia Yu Chi
Division of Clinical Research, National Health Research Institutes, Chunan, Miaoli, Taiwan
Pediatr Infect Dis J 27:640-5. 2008..The clinical features were compared with influenza A infection occurring in the same period...
- Isolation of influenza A/H3 and B viruses from an influenza patient: confirmation of co-infection by two influenza virusesShoichi Toda
Division of Biology, Yamaguchi Prefectural Research Institute of Public Health, Yamaguchi 753 0821, Japan
Jpn J Infect Dis 59:142-3. 2006
- An efficient RNA aptamer against human influenza B virus hemagglutininSubash C B Gopinath
Functional Nucleic Acids Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 Higashi, Tsukuba, Ibaraki 305 8566
J Biochem 139:837-46. 2006..The aptamer bound efficiently to the HA of influenza B and required 5 mM MgCl(2) ion for its recognition. The aptamer not only distinguished HA derived from the influenza A virus, but also inhibited HA-mediated membrane fusion...
- Virologically confirmed population-based burden of hospitalization caused by influenza A and B among children in Hong KongSusan S Chiu
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
Clin Infect Dis 49:1016-21. 2009..We sought to determine the virologically confirmed hospitalization rates associated with influenza virus infection among Hong Kong children...
- Comparison of nasopharyngeal nylon flocked swabs with universal transport medium and rayon-bud swabs with a sponge reservoir of viral transport medium in the diagnosis of paediatric influenzaSusanna Esposito
Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
J Med Microbiol 59:96-9. 2010....
- Subtyping of the influenza virus by high resolution mass spectrometryAlexander B Schwahn
School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
Anal Chem 81:3500-6. 2009..The approach represents a more rapid and direct approach with which to type and subtype the virus that is of critical need to prepare strategies and treatments in the event of a local epidemic or global pandemic...
- GS4071 is a slow-binding inhibitor of influenza neuraminidase from both A and B strainsW M Kati
Infectious Diseases Research, Abbott Laboratories, Illinois 60064, USA
Biochem Biophys Res Commun 244:408-13. 1998..The time dependent inhibition phenomenon, often referred to as slow-binding inhibition, appears to be a consequence of the very slow rate of dissociation of the compound from influenza neuraminidase...
- Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island, FranceA Falchi
INSERM, UMR S 707, Paris F 75012, France
J Clin Virol 41:148-51. 2008..The investigation of dual influenza infection human cases is of major interest specifically for the control of new emerging influenza strains...
- Congenital eye malformations associated with extensive periocular neural crest apoptosis after influenza B virus infection during early embryogenesisBo Yie Chen
School of Optometry, Chung Shan Medical University, Taichung, Taiwan
Mol Vis 15:2821-8. 2009..Infections acquired during gestation may disrupt eye morphogenesis. We investigated the effects of influenza B virus infection on eye malformations during early embryogenesis.
- Influenza vaccine: the challenge of antigenic driftF Carrat
Universite Pierre et Marie Curie, Paris 6, UMR S 707, Paris, France INSERM, UMR S 707, Paris, France
Vaccine 25:6852-62. 2007..In addition to the use of vaccine adjuvants, emerging research areas include development of a universal vaccine and the use of vaccines that exploit mechanisms of cross-protective immunity...
- Influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming?Emmanuel B Walter
Duke Clinical Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
Pediatrics 118:e570-8. 2006....
- Genetic analysis of influenza B viruses isolated in Uganda during the 2009-2010 seasonsDenis K Byarugaba
College of Veterinary Medicine, Makerere University, P, O, Box 7062, Kampala, Uganda
Virol J 10:11. 2013..Complete genome analysis of one influenza B virus and several gene segments of other influenza B viruses isolated from Uganda from May 2009 through December ..
- Immunogenicity, safety and reactogenicity of a mammalian cell-culture-derived influenza vaccine in healthy children and adolescents three to seventeen years of ageTimo Vesikari
University of Tampere Medical School, Tampere, Finland
Pediatr Infect Dis J 31:494-500. 2012..In this study, we compared the safety, reactogenicity and immunogenicity of CCIV with a conventional egg-derived trivalent influenza vaccine (TIV) in a healthy pediatric population...
- Co-infection of Influenza B and Streptococci causing severe pneumonia and septic shock in healthy womenTimothy Aebi
Medical Intensive Care Unit, University Hospital Basel, Basel, Switzerland
BMC Infect Dis 10:308. 2010....
- Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infectionChristopher D Paddock
Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
J Infect Dis 205:895-905. 2012b>Influenza B virus infection causes rates of hospitalization and influenza-associated pneumonia similar to seasonal influenza A virus infection and accounts for a substantial percentage of all influenza-related hospitalizations and deaths ..
- Differentiation of influenza B virus lineages Yamagata and Victoria by real-time PCRBarbara Biere
Robert Koch Institut, FG17 Influenza Respiratorische Viren, Nordufer 20, 13353 Berlin, Germany
J Clin Microbiol 48:1425-7. 2010..We present the first real-time PCR assay for virus lineage differentiation to supplement classical antigenic analyses. The assay was successfully applied to 310 primary samples collected in Germany from 2007 to 2009...
- Further characterisation of the translational termination-reinitiation signal of the influenza B virus segment 7 RNAMichael L Powell
Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 6:e16822. 2011..Reinitiation on distant AUGs is not inhibited in eIF4G-depleted RRL, suggesting that the tethered 40S subunit can move some distance without a requirement for linear scanning...
- Laboratory diagnosis of influenza--virology or serology?R Allwinn
Institute for Medical Virology, Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
Med Microbiol Immunol 191:157-60. 2002..In comparison, virus detection is clearly superior to antibody determination for diagnosis of influenza virus infections. However, antibody testing may be useful as a complementary tool to confirm the diagnosis retrospectively...
- Characterization of antibody responses to annual influenza vaccination over four years in a healthy elderly populationE M Gardner
Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
Vaccine 19:4610-7. 2001..This study clearly supports the concept that annual immunization with the same influenza vaccine component over multiple years does not significantly decrease antibody titers in a healthy elderly population...
- Transmission of influenza B viruses in the guinea pigNatalie Pica
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
J Virol 86:4279-87. 2012..We therefore present, for the first time, a small animal model with which to study the underlying mechanisms of influenza B virus transmission.
- Evolution of surface and nonstructural-1 genes of influenza B viruses isolated in the Province of Québec, Canada, during the 1998-2001 periodYacine Abed
Infectious Disease Research Center, Centre Hospitalier Universitaire de Quebec, Quebec City, Canada
Virus Genes 27:125-35. 2003..This study confirms the importance of a detailed molecular analysis for understanding the evolution of influenza B viruses...
- Monoclonal antibody, but not synthetic peptide, targeting the ectodomain of influenza B virus M2 proton channel has antiviral activityYongjin Wang
Laboratory of Wildlife Epidemic Diseases, East China Normal University, Shanghai 200062, China
New Microbiol 33:311-7. 2010The proton channels of influenza A virus (A/M2) and influenza B virus (BM2) are essential for viral replication...
- The rationale for quadrivalent influenza vaccinesChristopher S Ambrose
MedImmune, LLC, Gaithersburg, MD, USA
Hum Vaccin Immunother 8:81-8. 2012..However, licensed trivalent seasonal influenza vaccines contain antigens from only a single influenza B virus and thus provide limited immunity against circulating influenza B strains of the lineage not present in the ..
- The phosphorylation of the integral membrane (M1) protein of influenza virusA Gregoriades
Department of Basic Sciences, New York College of Podiatric Medicine, NY 10035
Virus Res 16:27-41. 1990..4) The phosphate is located within or in close proximity to the major stretch of neutral and hydrophobic amino acids found in M1, as determined by analyzing cyanogen bromide fragments...
- Influenza-associated deaths among children in the United States, 2003-2004Niranjan Bhat
Epidemic Intelligence Service, Career Development Division, Office of Workforce and Career Development National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 353:2559-67. 2005..Although influenza is common among children, pediatric mortality related to laboratory-confirmed influenza has not been assessed nationally...
- Genetic and phenotypic analysis of reassortants of high growth and low growth strains of influenza B virusG M Vodeiko
Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics and Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Vaccine 21:3867-74. 2003..The studies identify multiple genes that may affect growth of influenza B viruses in eggs...
- Protective efficacy against pandemic influenza of seasonal influenza vaccination in children in Hong Kong: a randomized controlled trialBenjamin J Cowling
School of Public Health
Clin Infect Dis 55:695-702. 2012..The efficacy of seasonal influenza vaccination against 2009 pandemic influenza A(H1N1) remains unclear...
- Influenza B virus PB1 protein; nucleotide sequence of the genome RNA segment predicts a high degree of structural homology with the corresponding influenza A virus polymerase proteinS Kemdirim
Virology 152:126-35. 1986..domain and 90% of the proline residues found within the influenza A virus PB1 protein are conserved in the influenza B virus molecule...
- Antigenic structure of the influenza B virus hemagglutinin: nucleotide sequence analysis of antigenic variants selected with monoclonal antibodiesM T Berton
J Virol 52:919-27. 1984We report here the complete nucleotide sequence of the hemagglutinin (HA) gene of influenza B virus B/Oregon/5/80 and, through comparative sequence analysis, identify amino acid substitutions in the HA1 polypeptide responsible for the ..
- Fatal human metapneumovirus and influenza B virus coinfection in an allogeneic hematopoietic stem cell transplant recipientC Ghattas
Department of Internal Medicine, Saint Elizabeth Health Center, Youngstown, Ohio, USA
Transpl Infect Dis 14:E41-3. 2012..Coinfection with hMPV and influenza virus type B may have a poor outcome and can be fatal, especially in immunocompromised patients...
- Influenza B virus with modified hemagglutinin cleavage site as a novel attenuated live vaccineJürgen Stech
Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Greifswald, Insel Riems, Germany
J Infect Dis 204:1483-90. 2011..According to World Health Organization recommendations, current annual vaccines are composed of 2 type A and 1 type B virus-specific component...
- The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteinsA Pekosz
Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois 60208 3500, USA
Virology 237:439-51. 1997..orientation of CM2, the size of the ectodomain and cytoplasmic tail of CM2, and its ability to form disulfide-linked oligomers are reminiscent of the structural properties of influenza A virus M2 and influenza B virus NB proteins.
- Detection of type B influenza virus genes from biopsied gastric mucosaYukiharu Hayase
Department of Virology, Jichi Medical School, Kawachi, Tochigi, Japan
J Gastroenterol 37:101-5. 2002..The purpose of the present study was to further characterize gastric mucosal infection with type B influenza virus, in which the natural host is limited to humans...
- The BM2 protein of influenza B virus is synthesized in the late phase of infection and incorporated into virions as a subviral componentT Odagiri
Department of Microbiology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
J Gen Virol 80:2573-81. 1999The influenza B virus genome RNA segment 7 encodes the M1 and BM2 proteins...
- Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic TestCHRISTOPHER GERARD COONEY; Fiscal Year: 2012..identifies hypervariable genomes across the following panel of respiratory pathogens: influenza A virus, influenza B virus, human respiratory syncytial virus A/B, human adenovirus A/B/C/D/E/F, human coronavirus 229E/NL63/OC43, ..
- The influenza A virus nucleoprotein: structure and functionYizhi Jane Tao; Fiscal Year: 2012..NP on its various functions;and (5) solve the structure of NP from infectious salmon anemia virus (ISAV) and influenza B virus and determine whether NP self-oligomerization and RNA binding modes are broadly conserved in the ..
- REPLICATION OF INFLUENZA VIRUSRobert M Krug; Fiscal Year: 2013..The third aim focuses on how the NS1 protein of influenza B virus (NS1B) inhibits the antiviral activity of the interferon-induced ISG15 protein, which can be conjugated to ..
- AvanceIII 700MHz NMR spectrometer with cryogenic probeJames J Chou; Fiscal Year: 2010..continued focus on proton translocators, the Chou lab will determine the structure of the BM2 H+ channel of influenza B virus, for providing structural details for designing new anti-flu compounds...
- Structural and Functional Study of Influenza Virus HemagglutininQinghua Wang; Fiscal Year: 2013DESCRIPTION (provided by applicant): Infection caused by influenza B virus remains a serious threat to global healthcare, due to naturally evolving strains and to their potential use as manmade bio-weapons by terrorists...
- Structure of M2 proton channel from influenza A VirusWilliam F Degrado; Fiscal Year: 2013..Finally we will structurally characterize the proton channel of influenza B virus, BM2, which shows no sequence similarity to M2 aside from having a His-X3-Trp motif...
- NanI sialidase enhances C. perfringens host cell adherence and toxin actionJihong Li; Fiscal Year: 2013..perfringens diseases, similar to the use of sialidase inhibitors in the treatment of influenza caused by influenza A virus and influenza B virus.
- INFLUENZA B VIRUS AND MATRIX GENE ORFDAN DEBORDE; Fiscal Year: 1990..Research directed at influenza B virus has benefited greatly from studies performed on influenza A viruses...
- Virulence factors of influenza virus: The NS1 proteinAdolfo Garcia Sastre; Fiscal Year: 2010..Our recent results indicate that the NS1 of influenza B virus (less than 25% amino acid identity with the NS1 of influenza A virus) also prevents the induction of IRF-3 ..
- Transgenic indicator cells for influenza virusPAUL OLIVO; Fiscal Year: 2006..constructs to generate stable cell lines that express a reporter gene only in response to influenza A and/or influenza B virus infection...
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMKaren Chachu; Fiscal Year: 2005..modulates DC differentiation in human cell lines, iSG15 is induced by several viruses including HCMV, HSV-1, influenza B virus and gammaHV68. However, the exact role of ISG15 during viral infection remains to be characterized...
- Reducing Transmission of Influenza by Face MasksARNOLD MONTO; Fiscal Year: 2008..Such a reduction could have a major public health impact during a pandemic. In the second year, the study can be expanded or modified based on findings in the first. ..
- Comparative Study of Influenza Vaccines in AdultsARNOLD MONTO; Fiscal Year: 2006..Results will help to determine how the vaccine may be used as part of the strategy to combat influenza in varying situations. [unreadable] [unreadable]..
- 2nd Orthomyxoviruses Research ConferenceJonathan McCullers; Fiscal Year: 2003..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
- Synergism Between Influenza Virus and PneumococcusJonathan McCullers; Fiscal Year: 2009....
- 3rd Orthomyxoviruses Research ConferenceJonathan McCullers; Fiscal Year: 2005..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
- Reconstitution of Protective CMV Immunity and Immune Regulation After HAARTAdriana Weinberg; Fiscal Year: 2008..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
- Influenza-pneumococcal synergism: role of neuraminidaseJonathan McCullers; Fiscal Year: 2004....
- Lethal synergism between influenza and pneumococcusJonathan McCullers; Fiscal Year: 2003....
- A randomized trial of influenza vaccination of Hutterite childrenMark Loeb; Fiscal Year: 2006..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
- A Novel Target for New Anti-Anthrax DrugsWayne Brouillette; Fiscal Year: 2007..Selectivity for the inhibition of Bacillus NAD synthetase over the human (erythrocyte) enzyme will also be evaluated. ..
- Elicitation of broad immunity using VLPs with consensus envsTed Ross; Fiscal Year: 2009..Finally, the breadth and protective efficacy of immune responses elicted by a SHIV-1 VLP containing an envelope representing the consensus envelope sequence of clade C (Con C) will be evaluated with a clade B SHIV challenge. ..
- Vulnerability to Smallpox Due to Declining CTL ImmunityInnocent Mbawuike; Fiscal Year: 2003..By correlating these responses with vaccinia lesion sizes in new vaccinees, markers of severe complications from vaccinia vaccination may be identified. ..
- Diagnostic protein array for respiratory infectionsDarrell Chandler; Fiscal Year: 2008..The underlying platform developed herein will likewise find broad application in many areas of disease surveillance, with an emphasis on point-of-use applications. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Dielectrophoretic Separator for Cell/Pathogen SeparationYing Huang; Fiscal Year: 2003..There examples address the needs of lowering the threshold for detection of cancer cells in blood, with the goal of diagnosing infectious disease and biowarfare agents without the need to first culture the pathogens. ..
- Role of Virus and Genetic Susceptibility in Otitis MediaCuneyt Alper; Fiscal Year: 2006..These results will be used in the design of future studies that prevent OM by moderating vURI pathogenesis. [unreadable] [unreadable]..
- Studies on Influenza B Virus BM2 Protein Ion ChannelLAWRENCE PINTO; Fiscal Year: 2009..Influenza A virus has caused all human pandemics but influenza B virus infections occur annually and in some recent years they have constituted 50% of total influenza virus ..
- IL-6 IN HERPES SIMPLEX VIRUS TYPE 1 OCULAR REACTIVATIONJOHN KRIESEL; Fiscal Year: 2002..Novel and specific viral mutants will be constructed based on the results of HSV-DNA binding and transient expression assays. ..
- A Novel Genetic Therapy for Herpes KeratitisJOHN KRIESEL; Fiscal Year: 2006..An ex vivo model of HSV-1 reactivation in explanted mouse trigeminal ganglia is proposed as an efficient means for determining effective strategies for the delay or inhibition of reactivation. ..
- Accelerated Viral Inhibition AssayMaryna Eichelberger; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Integrated, on-chip RT-MME-PCR for influenza diagnostics; Phase 1 = sample preparDarrell Chandler; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- High Throughput Assays for Ion Channel Activities of Influenza A & B VirusesLAWRENCE PINTO; Fiscal Year: 2006..Influenza A virus has caused all human pandemics and influenza B virus infections occur annually and in some recent years they have constituted 50% of total influenza virus ..
- RESPIRATORY VIRUS ION CHANNELSLAWRENCE PINTO; Fiscal Year: 2007..5. In a separate set of experiments we will use a sensitive method to test the NB protein of influenza B virus for ion channel activity. [unreadable] [unreadable] [unreadable]
- Mechanisms of influenza NA drug resistanceJennifer L McKimm Breschkin; Fiscal Year: 2010....
- Multiplexed pathogen detection by on-chip amplificationDarrell Chandler; Fiscal Year: 2008..unreadable] [unreadable]..
- TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLYInnocent Mbawuike; Fiscal Year: 2001....
- New Influenza A Neuraminidase Inhibitors for BiodefenseWayne Brouillette; Fiscal Year: 2009..Aim 4. Evaluate whole cell antiviral activity, mammalian cytotoxicity, and in vivo anti-influenza A activity. ..
- INITIATION OF VIRUS SPECIFIC CD8+ T CELL RESPONSESMaryna Eichelberger; Fiscal Year: 2002..This proposal is designed as an essential step towards the development of more effective influenza vaccine. ..
- Neonatal Immunization with Acellular Pertussis VaccinesNatasha Halasa; Fiscal Year: 2007....
- ANTIBODY RESPONSE IN INFLUENZA VIRUS INFECTIONWalter Gerhard; Fiscal Year: 2004....
- Rapid Analysis of Influenza Vaccine EffectivenessEdward Belongia; Fiscal Year: 2007..Interim and annual estimates of VE with 95% confidence intervals will be provided to CDC, including overall VE and VE for each of the priority age groups. ..
- Sixth International Respiratory Syncytial Virus SymposiumANN FALSEY; Fiscal Year: 2007..abstract_text> ..