herpesviridae

Summary

Summary: A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.

Top Publications

  1. pmc Herpesvirus entry: an update
    Patricia G Spear
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:10179-85. 2003
  2. pmc Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis
    Yi Wei Tang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Microbiol 41:2633-40. 2003
  3. pmc The order Herpesvirales
    Andrew J Davison
    MRC Virology Unit, Institute of Virology, University of Glasgow, Glasgow, UK
    Arch Virol 154:171-7. 2009
  4. ncbi A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae
    Lisa M Kattenhorn
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Mol Cell 19:547-57. 2005
  5. pmc The major portal of entry of koi herpesvirus in Cyprinus carpio is the skin
    B Costes
    Immunology Vaccinology B43b, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B 4000 Liege, Belgium
    J Virol 83:2819-30. 2009
  6. pmc Replication-competent bacterial artificial chromosomes of Marek's disease virus: novel tools for generation of molecularly defined herpesvirus vaccines
    Lawrence Petherbridge
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom
    J Virol 77:8712-8. 2003
  7. pmc Subversion of the actin cytoskeleton during viral infection
    Matthew P Taylor
    Department of Molecular Biology, Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Microbiol 9:427-39. 2011
  8. pmc Translational control of viral gene expression in eukaryotes
    M Gale
    University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Microbiol Mol Biol Rev 64:239-80. 2000
  9. pmc Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis
    Veronika Pozharskaya
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7559. 2009
  10. pmc Two modes of herpesvirus trafficking in neurons: membrane acquisition directs motion
    Sarah E Antinone
    Department of Microbiology Immunology, Ward, Rm 10 105, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Virol 80:11235-40. 2006

Detail Information

Publications331 found, 100 shown here

  1. pmc Herpesvirus entry: an update
    Patricia G Spear
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:10179-85. 2003
  2. pmc Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis
    Yi Wei Tang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Microbiol 41:2633-40. 2003
    ..05). Immunohistochemistry for EBV or HHV-8 antigen showed viral antigen primarily in airway epithelial cells. These data support the concept that a herpesvirus could be a source of chronic antigenic stimulation in IPF...
  3. pmc The order Herpesvirales
    Andrew J Davison
    MRC Virology Unit, Institute of Virology, University of Glasgow, Glasgow, UK
    Arch Virol 154:171-7. 2009
    ..The former family Herpesviridae has been split into three families, which have been incorporated into the new order Herpesvirales...
  4. ncbi A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae
    Lisa M Kattenhorn
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Mol Cell 19:547-57. 2005
    ..Sequence alignment of the large tegument proteins across the family Herpesviridae indicates conservation of key catalytic residues amongst these viruses...
  5. pmc The major portal of entry of koi herpesvirus in Cyprinus carpio is the skin
    B Costes
    Immunology Vaccinology B43b, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B 4000 Liege, Belgium
    J Virol 83:2819-30. 2009
    ..All the data obtained in the present study demonstrate that the skin, and not the gills, is the major portal of entry for KHV in carp...
  6. pmc Replication-competent bacterial artificial chromosomes of Marek's disease virus: novel tools for generation of molecularly defined herpesvirus vaccines
    Lawrence Petherbridge
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom
    J Virol 77:8712-8. 2003
    ....
  7. pmc Subversion of the actin cytoskeleton during viral infection
    Matthew P Taylor
    Department of Molecular Biology, Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Microbiol 9:427-39. 2011
    ..The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell...
  8. pmc Translational control of viral gene expression in eukaryotes
    M Gale
    University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Microbiol Mol Biol Rev 64:239-80. 2000
    ..We discuss how these translational strategies have been incorporated into the virus life cycle and examine how such programming contributes to the pathogenesis of the host cell...
  9. pmc Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis
    Veronika Pozharskaya
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7559. 2009
    ..We hypothesize that EMT in this model of virus-induced pulmonary fibrosis is driven by the expression of the transcription factor Twist...
  10. pmc Two modes of herpesvirus trafficking in neurons: membrane acquisition directs motion
    Sarah E Antinone
    Department of Microbiology Immunology, Ward, Rm 10 105, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Virol 80:11235-40. 2006
    ..These findings show that cytosolic capsids are trafficked to the neuronal cell body and that viral egress in axons occurs after capsids are enshrouded in a membrane envelope...
  11. pmc Cyprinid herpesvirus 3
    Benjamin Michel
    University of Liege, Liege, Belgium
    Emerg Infect Dis 16:1835-43. 2010
    ..nonreplicative). Recent advances with regard to CyHV-3 provide a role for this virus in fundamental and applied research...
  12. ncbi Molecular characterization of the genome of duck enteritis virus
    Yufeng Li
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Virology 391:151-61. 2009
    ..Therefore, our data based on the genomic analysis suggest that DEV represents an osculant taxonomic entity within the Alphaherpesvirinae...
  13. pmc Toward a comprehensive phylogeny for mammalian and avian herpesviruses
    D J McGeoch
    Medical Research Council Virology Unit, Institute of Virology, Glasgow G11 5JR, United Kingdom
    J Virol 74:10401-6. 2000
    ..The final tree obtained represents the most detailed view to date of phylogenetic relationships in any family of large-genome viruses...
  14. pmc A gamma-herpesvirus glycoprotein complex manipulates actin to promote viral spread
    Michael B Gill
    Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 3:e1808. 2008
    ..Gp48/ORF58 therefore represents a conserved module by which gamma-herpesviruses rearrange cellular actin to increase intercellular contacts and thereby promote their spread...
  15. ncbi Herpes virus infected spermatozoa following density gradient centrifugation for IVF purposes
    V Michou
    Locus Medicus SA, Ampelokipi, Athens, Greece
    Andrologia 44:174-80. 2012
    ..Further studies are required to determine whether any correlation exists between their presence, implantation rate and the outcome of pregnancy...
  16. pmc Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network
    Andrea Lisco
    Section of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 205:97-105. 2012
    ..However, semen is not just a mere passive transporter of virions but also plays an active role in HIV-1 transmission through cytokines and other biological factors...
  17. pmc Actin in herpesvirus infection
    Kari L Roberts
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Viruses 3:336-46. 2011
    ..The goal of this review is to explore these processes and to highlight potential future directions for this area of research...
  18. ncbi Herpesvirus latency confers symbiotic protection from bacterial infection
    Erik S Barton
    Departments of Pathology and Immunology, Washington University Medical School, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 447:326-9. 2007
    ..Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host...
  19. pmc Herpesvirus systematics
    Andrew J Davison
    MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    Vet Microbiol 143:52-69. 2010
    ..The former family Herpesviridae was elevated to a new order, the Herpesvirales, which now accommodates 3 families, 3 subfamilies, 17 genera ..
  20. pmc Integrating reptilian herpesviruses into the family herpesviridae
    Duncan J McGeoch
    MRC Virology Unit, Institute of Virology, Church St, Glasgow G11 5JR, United Kingdom
    J Virol 79:725-31. 2005
    ....
  21. ncbi Escape of herpesviruses from the nucleus
    Chung Pei Lee
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Rev Med Virol 20:214-30. 2010
    ....
  22. ncbi Identification of novel alpha- and gammaherpesviruses from cutaneous and mucosal lesions of dolphins and whales
    Kara A Smolarek Benson
    Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    J Virol Methods 136:261-6. 2006
    ..The sequencing data strongly suggest that these viruses are most likely cetacean specific and possibly have coevolved with their cetacean hosts...
  23. ncbi A novel fish herpesvirus of Osmerus eperlanus
    Nurith J Jakob
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Virus Genes 41:81-5. 2010
    ..All attempts to study host range of HVOE1 failed as no virus replication was observed, indicating that infectivity was lost or the suitable cell culture was missing. The genomic DNA of HVOE1 was analyzed by DNA restriction endonucleases...
  24. ncbi Phylogenetic relationships in the family Alloherpesviridae
    Thomas B Waltzek
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Dis Aquat Organ 84:179-94. 2009
    ..of the fish and amphibian HVs (Alloherpesviridae) separate from the HVs of mammals, birds, and reptiles (Herpesviridae) and the single recognized HV of bivalve mollusks (Malacoherpesviridae) in the order Herpesvirales...
  25. ncbi Evidence for interspecies transmission of oyster herpesvirus in marine bivalves
    I Arzul
    IFREMER, , 17390 La Tremblade, France MRC Virology Unit, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 82:865-70. 2001
    ..The results demonstrate that OsHV1 is capable of infecting several bivalve species, and this raises the possibility that interspecies transmission may be promoted by intensive rearing in modern hatcheries...
  26. ncbi Molecular analysis of US10, S3, and US2 in duck enteritis virus
    Yan Zhao
    Northeast Agricultural University, Harbin, 150030, China
    Virus Genes 38:243-8. 2009
    ..Phylogenetic analysis suggests that the DEV C-KCE strain is more closely related to Mardivirus in the alphaherpesvirus subfamily of the Herpesviridae.
  27. pmc Cloning of the koi herpesvirus genome as an infectious bacterial artificial chromosome demonstrates that disruption of the thymidine kinase locus induces partial attenuation in Cyprinus carpio koi
    B Costes
    Immunology Vaccinology B43b, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B 4000 Liege, Belgium
    J Virol 82:4955-64. 2008
    ..The availability of the KHV BAC is an important advance that will allow the study of viral genes involved in KHV pathogenesis, as well as the production of attenuated recombinant candidate vaccines...
  28. pmc Actin' up: herpesvirus interactions with Rho GTPase signaling
    Celine Van den Broeke
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
    Viruses 3:278-92. 2011
    ..The current review gives an overview of both general and individual interactions of herpesviruses with Rho GTPase signaling...
  29. ncbi Complete genomic sequence and an infectious BAC clone of feline herpesvirus-1 (FHV-1)
    S H Sheldon Tai
    Graduate Program in Comparative Medicine and Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Virology 401:215-27. 2010
    ..The virus regenerated from the BAC was very similar to the parental C-27 strain in vitro in terms of plaque morphology and growth characteristics and highly virulent in cats in a preliminary in vivo study...
  30. pmc Primary structure of the alcelaphine herpesvirus 1 genome
    A Ensser
    Institut für Klinische und Molekulare Virologie der Universität, Erlangen Nüberg, Germany
    J Virol 71:6517-25. 1997
    ....
  31. ncbi Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae
    Thomas B Waltzek
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 86:1659-67. 2005
    ..analysed in order to determine the relatedness of koi herpesvirus (KHV) to three fish viruses in the family Herpesviridae: carp pox herpesvirus (Cyprinid herpesvirus 1, CyHV-1), haematopoietic necrosis herpesvirus of goldfish (..
  32. ncbi Identification of envelope protein pORF81 of koi herpesvirus
    Daniela Rosenkranz
    Institute of Molecular Biology, Federal Research Institute for Animal Health, 17493 Greifswald Insel Riems, Germany
    J Gen Virol 89:896-900. 2008
    ..The antiserum was also suitable for the detection of pORF81 in sections of gills, kidneys, hepatopancreas and skin of KHV-infected carp by immunohistochemistry...
  33. pmc The functions of herpesvirus-encoded microRNAs
    Finn Grey
    Vaccine and Gene Therapy Institute, Oregon Health Sciences University, 505 NW 185th Ave, Portland, OR 97006, USA
    Med Microbiol Immunol 197:261-7. 2008
    ..In this review, we will cover the identification and characterization of miRNAs expressed in the herpesvirus family and discuss the potential significance of their role in viral infection...
  34. ncbi Cloning, expression, purification and characterization of UL24 partial protein of duck enteritis virus
    Renyong Jia
    Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Ya an 625014, China
    Intervirology 52:326-34. 2009
    ..On the basis of subcellular location, UL24 appeared to be predominantly nuclear membrane-associated, especially at later times in infection, and provided a good tool to further study the biofunctions of UL24 protein...
  35. ncbi Membrane fusion mediated by herpesvirus glycoproteins: the paradigm of varicella-zoster virus
    Nancy L Cole
    Departments of Microbiology and Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Rev Med Virol 13:207-22. 2003
    ....
  36. ncbi A novel class of herpesvirus with bivalve hosts
    Andrew J Davison
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 86:41-53. 2005
    Ostreid herpesvirus 1 (OsHV-1) is the only member of the Herpesviridae that has an invertebrate host and is associated with sporadic mortality in the Pacific oyster (Crassostrea gigas) and other bivalve species...
  37. ncbi Unique sequence characteristics of genes in the leftmost region of unique long region in duck enteritis virus
    Xiaoli Liu
    Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China
    Intervirology 52:291-300. 2009
    Our objective was to further understand the evolutionary position of duck enteritis virus (DEV) in the family Herpesviridae and to determine the genomic structure in the leftmost region of the unique long region (UL) of DEV.
  38. ncbi Purification of a herpes-like virus from abalone (Haliotis spp.) with ganglioneuritis and detection by transmission electron microscopy
    Jianming Tan
    Department of Primary Industries, 475 Mickleham Road, Attwood, VIC 3049, Australia
    J Virol Methods 149:338-41. 2008
    ..The described method, whilst proving successful for purifying a herpes-like virus from abalone, may also be applicable to other viruses from marine animals...
  39. ncbi Herpes-like virus infection causing mortality of cultured abalone Haliotis diversicolor supertexta in Taiwan
    Pen Heng Chang
    Department of Veterinary Medicine, College of Bio Resources and Agriculture, National Taiwan University, Taipei 10617, Taiwan, ROC
    Dis Aquat Organ 65:23-7. 2005
    ..Experimental infection using supernatant collected from minced visceral organs and muscle of moribund abalone induced 100 % mortality through both intramuscular injection and bath treatments...
  40. ncbi Topics in herpesvirus genomics and evolution
    Duncan J McGeoch
    Medical Research Council Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    Virus Res 117:90-104. 2006
    ..At a finer level, the structure of the capsid shell protein further suggests an element of common origin between herpesviruses and tailed DNA bacteriophages...
  41. ncbi Herpesvirus assembly: an update
    Thomas C Mettenleiter
    Friedrich Loeffler Institut, 17493 Greifswald Insel Riems, Germany
    Virus Res 143:222-34. 2009
    ..animals from molluscs to men with a common virion morphology which have been classified into the families Herpesviridae, Alloherpesviridae and Malacoherpesviridae...
  42. ncbi Identification and isolation of psittacid herpesvirus from psittacids in Brazil
    Marcela Miranda Luppi
    Laboratório de Virologia Comparada, Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais Av Antonio Carlos, 6627, Belo Horizonte, MG, Brazil
    Vet Microbiol 154:69-77. 2011
    ..Thus, a total of 41 isolates were obtained from PsHV cell cultivation in CEF, confirming the circulation of the virus between parrots kept in captivity in Belo Horizonte, and affirming the importance of further studies in this area...
  43. ncbi [BAC system: A novel method for manipulation of herpesvirus genomes based on bacterial genetics]
    Yasushi Kawaguchi
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Uirusu 54:255-64. 2004
    ..This 'BAC system' has opened new avenues for reverse and forward genetics of herpesviruses in basic research and in vector development for human therapy. Here we describe the principle of the 'BAC system' in herpesvirus researches...
  44. ncbi Fatal columbid herpesvirus-1 infections in three species of Australian birds of prey
    D N Phalen
    Wildlife Health and Conservation Centre, University of Sydney, Camden 2570, New South Wales, Australia
    Aust Vet J 89:193-6. 2011
    ..These findings increase the number of known species of birds of prey that are susceptible to CoHV-1 infection and indicate that rock pigeons (Columbia livia) should not be included in the diet of captive Australian birds of prey...
  45. ncbi Herpes simplex-like infection in a bottlenose dolphin stranded in the Canary Islands
    F Esperón
    Animal Health Research Centre CISA INIA, Ctra Algete a El Casar s n, Madrid, Spain
    Dis Aquat Organ 81:73-6. 2008
    ..02) with Human herpesvirus 1 (herpes simplex virus 1 or HSV-1). This is the first report of a herpes simplex-like infection in a stranded dolphin...
  46. ncbi Attachment of the gammaherpesvirus bovine herpesvirus 4 is mediated by the interaction of gp8 glycoprotein with heparinlike moieties on the cell surface
    A Vanderplasschen
    Department of Virology Immunology, Faculty of Veterinary Medicine, University of Liege, Belgium
    Virology 196:232-40. 1993
    ..Therefore, this study extends the group of herpesviruses interacting with heparinlike moieties at the cell surface to a member of the gammaherpesvirinae subfamily...
  47. ncbi Understanding human T-cell-mediated immunoregulation through herpesviruses
    Scott R Burrows
    Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Immunol Cell Biol 89:352-8. 2011
    ..It is highly likely that these newly emerging T-cell-based therapeutic and diagnostic technologies will revolutionize the clinical management of patients with herpesvirus-associated diseases...
  48. pmc Conserved herpesvirus protein kinases
    Edward Gershburg
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochim Biophys Acta 1784:203-12. 2008
    Conserved herpesviral protein kinases (CHPKs) are a group of enzymes conserved throughout all subfamilies of Herpesviridae. Members of this group are serine/threonine protein kinases that are likely to play a conserved role in viral ..
  49. ncbi Rapid detection of pigeon herpesvirus, fowl adenovirus and pigeon circovirus in young racing pigeons by multiplex PCR
    Markus Freick
    Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D 04103 Leipzig, Germany
    J Virol Methods 148:226-31. 2008
    ..The usefulness of the multiplex PCR was demonstrated by re-investigation of liver samples from young racing pigeons previously tested positive by uniplex PCRs...
  50. ncbi Columbid herpesvirus-1 in two Cooper's hawks (Accipiter cooperii) with fatal inclusion body disease
    Marie E Pinkerton
    Veterinary Diagnostic Laboratory and Department of Pathobiology, College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    J Wildl Dis 44:622-8. 2008
    ..PCR results provide evidence that this disease is transmitted to raptors via Rock Pigeons, most likely through ingestion of Rock Pigeons as prey...
  51. ncbi Herpesviruses: a brief overview
    Mathias Ackermann
    Institute of Virology, University of Zurich, Switzerland
    Methods Mol Biol 256:199-219. 2004
  52. ncbi Systemic herpesvirus and morbillivirus co-infection in a striped dolphin (Stenella coeruleoalba)
    S Soto
    Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona UAB, 08193 Bellaterra, Barcelona, Spain
    J Comp Pathol 146:269-73. 2012
    ..To our knowledge, this is the first report of a cetacean co-infected by dolphin morbillivirus and herpesvirus with evidence of lesions attributable to both viruses...
  53. ncbi Viral diagnosis of neurological infection by RT multiplex PCR: a search for entero- and herpesviruses in a prospective study
    I Casas
    Service of Diagnostic Microbiology, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Med Virol 57:145-51. 1999
    ..The applications of this RT multiplex PCR assay are extensive and may prove to be particularly valuable for the rapid and sensitive diagnosis of neurological diseases in both immunocompetent and immunocompromised patients...
  54. ncbi Concentrations of a Koi herpesvirus (KHV) in tissues of experimentally infected Cyprinus carpio koi as assessed by real-time TaqMan PCR
    Oren Gilad
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Dis Aquat Organ 60:179-87. 2004
    ..Koi surviving infection at 62 to 64 d post virus exposure contained lower KHV genome copies (up to 1.99 x 10(2) per 10(6) host cells) as present in gill, kidney or brain tissues...
  55. ncbi Diagnosis of herpesvirus infections of the central nervous system
    Stephan W Aberle
    Institute of Virology, University of Vienna, Austria, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Clin Virol 25:S79-85. 2002
    ..Human herpesviruses may cause infections of the central nervous system (CNS). The early diagnosis of herpesvirus-associated neurological diseases is of high importance...
  56. pmc Columbid herpesvirus-1 mortality in great horned owls (Bubo virginianus) from Calgary, Alberta
    Nicole Rose
    University of Calgary, Faculty of Veterinary Medicine, TRW 2D01, 3280 Hospital Drive NW, Calgary, Alberta T2N 2Z6
    Can Vet J 53:265-8. 2012
    ..The sequence of a PCR amplicon had 99.7% homology to Columbid herpesvirus-1...
  57. ncbi Entry of herpesviruses into cells: more than one way to pull the trigger
    Ekaterina E Heldwein
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Structure 17:147-9. 2009
    ..The structure of gp42 reported by Kirschner etal. (2009) in this issue of Structure suggests a likely triggering mechanism substantially different from that of a related herpesvirus...
  58. ncbi Detection of koi herpesvirus in common carp, Cyprinus carpio L., by loop-mediated isothermal amplification
    I Gunimaladevi
    United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima, Japan
    J Fish Dis 27:583-9. 2004
    ..The detection limit using LAMP was found to be similar to that by polymerase chain reaction. In this study, we have developed a highly sensitive and rapid diagnostic procedure for detection of KHV infection in common carp...
  59. ncbi Broad screening for human herpesviridae DNA in multiple sclerosis cerebrospinal fluid and serum
    Diego Franciotta
    Laboratory of Neuroimmunology, IRCCS, Foundation Neurological Institute C Mondino, Pavia, Italy
    Acta Neurol Belg 109:277-82. 2009
    Members of the human herpesviridae family are candidates for representing the macroenvironmental factors associated with multiple sclerosis (MS) pathogenesis...
  60. pmc Herpesviruses and intermediate filaments: close encounters with the third type
    Laura Hertel
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Viruses 3:1015-40. 2011
    ..These interactions, either known or potential, will be the focus of this review...
  61. ncbi Subclinical herpesvirus infection in farmed turbot Scophthalmus maximus
    H Hellberg
    National Veterinary Institute Bergen, Norway
    Dis Aquat Organ 49:27-31. 2002
    ..This is the first report of herpesvirus infection in turbot in Norway...
  62. ncbi Susceptibility of koi x crucian carp and koi x goldfish hybrids to koi herpesvirus (KHV) and the development of KHV disease (KHVD)
    S M Bergmann
    Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Institute of Infectology, Greifswald Insel Riems, Germany
    J Fish Dis 33:267-72. 2010
    ..The present study showed severe losses after a waterborne KHV infection of between 35% and 100% in koi x goldfish and koi x crucian carp hybrids as well as in SPF carp...
  63. ncbi Molecular detection of a virus, Pilchard herpesvirus, associated with epizootics in Australasian pilchards Sardinops sagax neopilchardus
    Melanie Crockford
    Department of Fisheries Western Australia, PO Box 20, North Beach, Western Australia 6920, Australia
    Dis Aquat Organ 68:1-5. 2005
    ..Sequence analysis of amplified fragment resulting from this PCR is different from all known herpesviruses and can therefore distinguish PHV from all known viruses...
  64. ncbi Detection of the herpesviral hematopoietic necrosis disease agent (Cyprinid herpesvirus 2) in moribund and healthy goldfish: validation of a quantitative PCR diagnostic method
    A E Goodwin
    University of Arkansas at Pine Bluff, Aquaculture Fisheries Center, Arkansas 71601, USA
    Dis Aquat Organ 69:137-43. 2006
    ..The assay detects CyHV-2 not just in clinical cases of HVHN but also in apparently healthy 1 yr old goldfish fingerlings and even in 3 to 5 yr old broodfish...
  65. ncbi Antibody response and resistance of Cyprinus carpio immunized with cyprinid herpes virus 3 (CyHV-3)
    Ayana Perelberg
    Dor Aquaculture Research Station, Ministry of Agriculture and Rural Development, 30820, Israel
    Vaccine 26:3750-6. 2008
    ..The fact that anti-virus antibodies neutralize in vitro the pathogenic effects of the virus emphasizes the central role probably played by the antibodies in anti-CyHV-3 protection in vivo...
  66. pmc The genome of salmonid herpesvirus 1
    A J Davison
    MRC Virology Unit, Institute of Virology, Glasgow, United Kingdom
    J Virol 72:1974-82. 1998
    ..The implications of these findings in herpesvirus taxonomy are discussed...
  67. ncbi Channel catfish reovirus (CRV) inhibits replication of channel catfish herpesvirus (CCV) by two distinct mechanisms: viral interference and induction of an anti-viral factor
    V G Chinchar
    Department of Microbiology, University of Mississippi Medical Center, Jackson 39216, USA
    Dis Aquat Organ 33:77-85. 1998
    ....
  68. ncbi Viral encephalitis of tilapia larvae: primary characterization of a novel herpes-like virus
    Mark Shlapobersky
    Laboratory of Fish Immunology and Genetics, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Virology 399:239-47. 2010
    ..Phylogenetic analysis, albeit limited, confirms this assumption and places TLEV within the family of Herpesviridae and distantly from the families Alloherpesviridae and Iridoviridae...
  69. ncbi Systemic herpes-like virus in catfish Ictalurus melas (Italy) differs from Ictalurid herpesvirus 1 (North America)
    Ronald P Hedrick
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Dis Aquat Organ 55:85-92. 2003
    ..nm in diameter surrounded by an envelope with a diameter of 227 nm (n = 20) typical for members of the family Herpesviridae. Virions of IcmHV purified from infected CCO cells contained 17 polypeptides ranging in size from 17...
  70. ncbi Susceptibility of channel catfish fry to Channel Catfish Virus (CCV) challenge increases with age
    Larry A Hanson
    Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi 39762, USA
    Dis Aquat Organ 62:27-34. 2004
    ..Additionally, we documented the level of vertical transmission of CCV. Fry from the 4 positive spawns had a CCV prevalence of 40 to 75 %...
  71. pmc Persistence of cyprinid herpesvirus 3 in infected cultured carp cells
    Arnon Dishon
    Department of Pathology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Virol 81:4828-36. 2007
    ....
  72. ncbi Susceptibility of cyprinid cultured cells to cyprinid herpesvirus 3
    M Davidovich
    Department of Pathology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Arch Virol 152:1541-6. 2007
    ..These results indicate that CyHV-3 is not restricted to common carp and koi, but other cyprinids are also vulnerable to the virus...
  73. ncbi Detection of Cyprinid herpesvirus-3 (CyHV-3) DNA in infected fish tissues by nested polymerase chain reaction
    Mansour El-Matbouli
    Institute of Zoology, Fish Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Munich, Germany
    Dis Aquat Organ 78:23-8. 2007
    ..The nested PCR test detected CyHV-3 DNA at a 10-fold lower concentration than a routinely used, 1-round test. Hence, the new method should provide more sensitive diagnosis of CyHV-3 infection among koi and carp populations...
  74. ncbi Morphogenesis of koi herpesvirus observed by electron microscopy
    S Miwa
    Inland Station, National Research Institute of Aquaculture, Tamaki, Mie, Japan
    J Fish Dis 30:715-22. 2007
    ..These observations support the inclusion of KHV in the family Herpesviridae.
  75. ncbi Poly I:C induces an antiviral state against Ictalurid Herpesvirus 1 and Mx1 transcription in the channel catfish (Ictalurus punctatus)
    Karen P Plant
    Pathobiological Sciences, School of Veterinary Medicine and Department of Veterinary Science, Louisiana State University Agricultural Center, Louisiana State University, Baton Rouge, LA 70803, USA
    Dev Comp Immunol 29:627-35. 2005
    ..In response to CCV, Mx1 transcription was not significantly elevated until day 3 post-challenge, but remained elevated in certain organs until day 7...
  76. ncbi Identification and characterization of a duck enteritis virus US3-like gene
    Hong Yi Xin
    Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Yaan, Sichuan 625014, China
    Avian Dis 53:363-9. 2009
    ..In short, the DEV US3-like gene and its in vivo protein expression were found for the first time, and DEV classification and the gene's functions were suggested...
  77. pmc A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation
    Keith Jarosinski
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 104:20025-30. 2007
    ..in the large tegument protein of herpes simplex virus 1 (HSV-1), is conserved across all members of the Herpesviridae. Whether this conservation is indicative of an essential function of the enzyme in vivo has not yet been ..
  78. ncbi Human herpesvirus latency
    R J Cohrs
    Department of Neurology, University of Colorado, Health Sciences Center, Denver 80262, USA
    Brain Pathol 11:465-74. 2001
    ..This review highlights the alphaherpesvirus, specifically herpes simplex virus type 1 and varicella-zoster virus, and describes the characteristics of latent infection...
  79. ncbi Characterization of the gene encoding glycoprotein C of duck enteritis virus
    Fengyuan Liu
    College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China
    Virus Genes 37:328-32. 2008
    ..Phylogenetic analysis of the DEV gC gene revealed that the gC gene had a close evolutionary relationship with the subfamily of Alphaherpesvirinae...
  80. pmc Viruses in the mammalian male genital tract and their effects on the reproductive system
    N Dejucq
    GERM INSERM U435, Universite de Rennes I, Campus de Beaulieu, 35042 Rennes Cedex, France
    Microbiol Mol Biol Rev 65:208-31 ; first and second pages, table of contents. 2001
    ..Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system...
  81. ncbi Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction
    S David Hudnall
    Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
    Transfusion 48:1180-7. 2008
    ..Also, blood-borne herpesvirus from healthy persistently infected blood donors can lead to active primary infection of immunocompromised transfusion recipients...
  82. pmc Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo
    Lisa M Gargano
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 83:1474-82. 2009
    ....
  83. ncbi Evolution of the herpesviruses
    Andrew J Davison
    MRC Virology Unit, Church Street, G11 5JR, Glasgow, UK
    Vet Microbiol 86:69-88. 2002
    ..The account focuses naturally on places where the grasp is secure, but also ventures where the bark is slippery and looks out on regions where footholds have not yet been established...
  84. pmc Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome
    M Messerle
    Max von Pettenkofer Institut für Hygiene und Mikrobiologie, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, D 81377 Munich, Germany
    Proc Natl Acad Sci U S A 94:14759-63. 1997
    ..The described approach should be generally applicable to the mutagenesis of genomes of other large DNA viruses...
  85. ncbi Latency sites and reactivation of duck enteritis virus
    Samia Shawky
    Cornell Duck Research Laboratory, Eastport, NY 11941, USA
    Avian Dis 46:308-13. 2002
    ..The reactivation of DEV occurred without any clinical evidence of the disease, but the virus was detected in PBL and CSs. We conclude from this study that DEV establishes latency in TG and lymphoid tissues including PBL...
  86. pmc Whole-proteome phylogeny of large dsDNA virus families by an alignment-free method
    Guohong Albert Wu
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:12826-31. 2009
    ....
  87. ncbi Results of total DNA measurement in koi tissue by Koi Herpes Virus real-time PCR
    Kathleen Eide
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    J Virol Methods 172:81-4. 2011
    ..2005). Although one of the unique features of Herpesviridae, the sister family of Herpesvirales, is latent infection, it has not been demonstrated consistently that KHV ..
  88. pmc Nonrandom clusters of palindromes in herpesvirus genomes
    Ming Ying Leung
    Department of Mathematical Sciences, University of Texas at El Paso, El Paso, TX 79968 0514, USA
    J Comput Biol 12:331-54. 2005
    ..This analysis brings out a few interesting extensions of the scan statistics that can help formulate an algorithm for more accurate prediction of replication origins...
  89. pmc Detection of anatid herpesvirus 1 gC gene by TaqMan fluorescent quantitative real-time PCR with specific primers and probe
    Qing Zou
    Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China
    Virol J 7:37. 2010
    ..1-gC DNA vaccine in infected ducks by TaqMan fluorescent quantitative real-time PCR assay (FQ-PCR) with pcDNA3.1-gC plasmid...
  90. ncbi Channel catfish virus gene 50 encodes a secreted, mucin-like glycoprotein
    N Vanderheijden
    Laboratoire de Biologie Moléculaire et de Génie Génétique, Universite de Liege, B6, Liege, B 4000, Belgium
    Virology 257:220-7. 1999
    ..Such genetic variations are a characteristic feature of mucin genes and are linked to crossing-over events between internal repeated sequences, such as those present in gene 50...
  91. ncbi Molecular cloning and sequence analysis of the duck enteritis virus UL5 gene
    Huaqi Pan
    Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, PR China
    Virus Res 136:152-6. 2008
    ....
  92. ncbi Herpesvirus genetics has come of age
    Markus Wagner
    Max von Pettenkofer Institute, Department of Virology, Gene Center, Ludwig Maximilians University, 81377 Munich, Germany
    Trends Microbiol 10:318-24. 2002
    ..Use of this technique could lead to new developments in clinical virology and basic virology research, and increase the usage of viral genomes as investigative tools and vectors...
  93. ncbi Molecular comparison of isolates of an emerging fish pathogen, koi herpesvirus, and the effect of water temperature on mortality of experimentally infected koi
    Oren Gilad
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 84:2661-7. 2003
    ..4-95.2 %) at 28 degrees C. Mortality (85.0 %) also occurred at 18 degrees C but not at 13 degrees C. Shifting virus-exposed fish from 13-23 degrees C resulted in the rapid onset of mortality...
  94. pmc Polyclonal antibody against the DPV UL46M protein can be a diagnostic candidate
    Liting Lu
    Avian Diseases Research Center, College of Veterinary Medicine of Sichuan Agricultural University, YA, AN, Sichuan, China
    Virol J 7:83. 2010
    ..Subsequently, we established Dot-ELISA using the polyclonal antibody and applied it to DPV detection...
  95. pmc A Thymidine Kinase recombinant protein-based ELISA for detecting antibodies to Duck Plague Virus
    Yongping Wen
    Avian Diseases Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Ya an, Sichuan, China
    Virol J 7:77. 2010
    ....
  96. ncbi Clinical, virological, and immunological parameters associated with superinfection of latently with FeHV-1 infected cats
    Marianne Richter
    Department of Small Animals, University of Zurich, Switzerland
    Vet Microbiol 138:205-16. 2009
    ..Since kittens are normally infected with wtFeHV-1 prior to the first immunization, the data described in this study may be valuable for designing future live attenuated FeHV-1 vaccines...
  97. ncbi Phylogenetic analysis, genome evolution and the rate of gene gain in the Herpesviridae
    Nan Wang
    Department of Ecology and Evolutionary Biology, UC Irvine, Irvine, CA 92697 2525, USA
    Mol Phylogenet Evol 43:1066-75. 2007
    We used complete sequence data from 30 complete Herpesviridae genomes to investigate phylogenetic relationships and patterns of genome evolution...
  98. ncbi Treatment of cats with ocular disease attributable to herpesvirus infection: 17 cases (1983-1993)
    J Stiles
    Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602 7390, USA
    J Am Vet Med Assoc 207:599-603. 1995
    ..Recombinant human alpha-interferon was given orally to 3 cats in conjunction with topical administration of antiviral agents. In addition to medical treatment, 4 cats were treated surgically.(ABSTRACT TRUNCATED AT 250 WORDS)..
  99. pmc Scoring schemes of palindrome clusters for more sensitive prediction of replication origins in herpesviruses
    David S H Chew
    Department of Mathematics, National University of Singapore Singapore
    Nucleic Acids Res 33:e134. 2005
    ..A list of predicted locations of replication origins in all the known herpesviruses with complete genome sequences is reported...
  100. ncbi Detection of herpesvirus genomes by polymerase chain reaction in cerebrospinal fluid and clinical findings
    Sophie Minjolle
    Laboratoire de Bacteriologie virologie, Universite Rennes 1, 2 avenue, du Pr Léon Bernard, CS 34317, 35 043 Rennes cedex, France
    J Clin Virol 25:S59-70. 2002
    The viruses of the Herpesviridae family, in particular herpes simplex virus types 1 (HSV-1) and 2 (HSV-2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zoster virus (VZV), and human herpesvirus 6 (HHV-6), are responsible ..
  101. ncbi Recent advances in herpesvirus genetics using bacterial artificial chromosomes
    A McGregor
    Department of Infectious Diseases and Immunity, University of California, 140 Earl Warren Hall School of Public Health, Berkeley, California 94720, USA
    Mol Genet Metab 72:8-14. 2001
    ..Manipulation of herpesvirus genomes is now feasible using the powerful techniques of bacterial genetics, and should facilitate a better understanding of the molecular pathogenesis of herpesvirus infections...

Research Grants74

  1. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2010
    ..N&N proposes to develop N-MCT as a therapeutic against the Herpesviridae, Papillomaviridae and Poxviridae genera of Class I dsDNA viruses, which include HSV-1, HSV-2, HSV-8, VZV, EBV, ..
  2. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ....
  3. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2013
    ..provided by applicant): Diseases associated with the Poxviridae (smallpox, vaccinia and cowpox viruses), and Herpesviridae (HSV-1, HSV-2, HSV-8, VZV, EBV) dsDNA viruses represent major worldwide public health problems...
  4. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): A number of viruses, including members of the Herpesviridae, can cause tumors in their hosts...
  5. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ....
  6. Regulation and Function of the HCMV pp71 Tegument Protein
    Julie Kerry; Fiscal Year: 2009
    ..This research will analyze the function and regulation of viral proteins involved in establishing infection and assembling new virus particles, and thus may identify novel targets for anti-HCMV therapies. ..
  7. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..Selected targets will be validated and the effect of their knockdown on virus replication determined. These experiments will uncover additional cell proteins or networks that could be targets for anti-viral therapeutic strategies. ..
  8. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ....
  9. IMMUNITY AND VIRUS DISEASE
    Raymond M Welsh; Fiscal Year: 2013
    ..abstract_text> ..
  10. Role of HSV Induced RNA Degradation in Pathogenesis
    David A Leib; Fiscal Year: 2013
    ..Specific inhibitors of virus-induced RNA destabilization might therefore be of value as broad-spectrum antivirals. This work is therefore of broad interest and application. ..
  11. Development of a Novel Vaccine Against Herpes Simplex Type 2
    DEBORAH SPECTOR; Fiscal Year: 2009
    ..S. population together with the medical and psychological impacts of the disease make HSV-2 an important candidate for the development of an effective vaccine that can prevent infection or disease. ..
  12. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..The goal of this research is to characterize the latency associated transcript gene (LAT) region and investigate the role of LAT during latency in a natural host model system. . ..
  13. Epigenetic regulation of viral infection and replication by periodontal bacteria
    Fengchun Ye; Fiscal Year: 2013
    ..The results should provide a scientific basis for developing novel strategies to prevent and treat recurrent HIV and herpesviral infections in HIV/AIDS patients simultaneously. ..
  14. The Pox Virion Molecular Interactome
    Paul D Gershon; Fiscal Year: 2013
    ....
  15. Mechanisms by which VZV IE proteins interact with cell antiviral proteins to prev
    MARIA ACENA NAGEL; Fiscal Year: 2013
    ..Thus, an understanding of viral and host cell interactions leading to VZV latency and reactivation will provide the basis for strategies to prevent serious neurological disease caused by VZV. ..
  16. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ....
  17. Mechanisms of Viral DNA Packaging
    CARLOS JOSE BUSTAMANTE; Fiscal Year: 2013
    ..Finally, we wish to investigate how the increasing internal DNA pressure regulates the dynamics of the motor during packaging. ..
  18. Modulation of histone deacetylase activity by a gammaherpesviral kinase
    Bryan C Mounce; Fiscal Year: 2013
    ..Several orf36 functions are conserved in other gammaherpesviral kinases;thus, the results of our studies are expected to translate to human pathogens. ..
  19. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
    ..abstract_text> ..
  20. 2nd ASM Conference on Manipulation of Nuclear Processes by DNA Viruses
    Laimonis A Laimins; Fiscal Year: 2011
    ..This conference is one of the few that will bring together these groups of investigators to freely share ideas and develop areas of future collaboration. ..
  21. Varicella-zoster Virus: Tegument Proteins in Pathogenesis
    Ann Arvin; Fiscal Year: 2012
    ..abstract_text> ..
  22. Development of a novel vaccine for protection against gammaherpesvirus infection
    Blossom A Damania; Fiscal Year: 2010
    ..Thus, this collaborative project integrates the PI's expertise in KSHV and RRV, with Dr. Desrosiers'expertise in vaccine design and development, and the use of primate infection models for RRV. ..
  23. Uncovering the Regulatory Role of gH/gL in HSV Fusion
    Roselyn J Eisenberg; Fiscal Year: 2013
    ..My research may suggest new therapeutic targets that will result in new treatments to stop the virus from gaining entry into its favorite target cells. ..
  24. Generation and Evaluation of KSHV VLPs as Vaccines
    GARY S contact HAYWARD; Fiscal Year: 2010
    ....
  25. ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVO
    Hidde L Ploegh; Fiscal Year: 2012
    ..The experiments proposed here will help identify and characterize as yet poorly understood players in antigen presentation, and will thus open up new areas for experimental manipulation of immune responses in health and disease. ..
  26. Conference Support for International Congress on Oncogenic Herpesviruses
    Paul M Lieberman; Fiscal Year: 2012
    ....
  27. Intra- and Inter-Neuronal Viral Trafficking
    Glenn F Rall; Fiscal Year: 2012
    ..Successful completion of the proposed aims will provide the foundation for the development of treatments to prevent or reverse the life-threatening consequences of chronic CNS infections caused by viruses. ..
  28. ASSEMBLY OF THE HERPES SIMPLEX VIRUS CAPSID
    Jay C Brown; Fiscal Year: 2012
    ..The goal of the proposed research is to study assembly of the virus capsid with the aim of identifying novel targets against which small molecule inhibitors might be directed. ..
  29. MOLECULAR GENETICS OF HSV DNA POLYMERASE GENE
    James M Hogle; Fiscal Year: 2013
    ..The research proposed should not only provide information that could aid in drug discovery and understanding how viruses become resistant to current drugs, but aims directly to discover new anti-herpesvirus drugs. ..
  30. T Cell Homeostasis and Function in Immune Senescence
    Janko Nikolich-Zugich; Fiscal Year: 2012
    ....
  31. Risk for in vivo mutagenesis of the P53 gene by nucleoside analog antiviral drug
    Vernon E Walker; Fiscal Year: 2011
    ..The main goal of this work is to determine exposure to AZT during pregnancy causes mutations in the P53 tumor suppressor that can be involved in the progression of cancer. ..
  32. Bedside-to-Bench Research Training for Pediatric Infectious Diseases Fellows
    Mark R Schleiss; Fiscal Year: 2013
    ..We anticipate that our trainees will be uniquely well prepared to lead translational investigative programs in pediatric infectious diseases in their academic research careers. ..
  33. Anti Herpesvirus Signaling by LTab and LIGHT
    Carl F Ware; Fiscal Year: 2013
    ..We have established a highly interactive group of virologists and autoimmune disease specialists as collaborators to assist in the experimental approach and data analysis. ..
  34. Epithelial-fibroblast Interactions in Lung Fibrosis
    Timothy S Blackwell; Fiscal Year: 2013
    ....
  35. Post-transcriptional Gene Regulation by EBV SM Protein
    Sankar Swaminathan; Fiscal Year: 2013
    ..This proposal is to study how EBV manipulates the infected cell to avoid the immune response (host defenses) and enhance its own replication. ..
  36. Immune evasion in a humanized mouse model of HHV-6 infection
    Amy W Hudson; Fiscal Year: 2013
    ..HHV-6 also reactivates in hematopoietic cell transplant recipients, resulting in poor neurocognitive outcome and can result in acute limbic encephalitis (3,4). ..
  37. Mechanisms of Viral DNA Packaging: Biophysical, Biochemical, &Genetic Analysis
    Douglas E Smith; Fiscal Year: 2013
    ..abstract_text> ..
  38. Interdisciplinary Training in Virology and Gene Therapy
    Ren Sun; Fiscal Year: 2013
    ....
  39. Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug Targeting
    James M Hogle; Fiscal Year: 2013
    ..The research proposed should not only provide information that could aid in understanding drug targets and mechanisms, but aims directly to discover new anti-HCMV drugs. ..
  40. KSHV-Ori-Lyt-Dependent DNA Replication
    Yan Yuan; Fiscal Year: 2012
    ..The study aims to new therapeutic strategies to block KSHV replication and treat KSHV-associated human diseases. ..
  41. Maturation functions of the HSV-1 tegument
    Prashant Desai; Fiscal Year: 2010
    ..translocation, Golgi stabilization, Golgi trafficking, virion incorporation and protein-protein interactions This analysis will identify domains of the proteins that have the potential to be used as targets for antiviral intervention ..
  42. Transport and Insertion of Outer Membrane Proteins
    Sangita Sinha; Fiscal Year: 2009
    The 3-herpesviridae includes widespread, important human pathogens like Epstein-Barr virus which causes infectious mononucleosis and malignant tumors of lymphoid and epithelial tissues and Kaposi Sarcoma virus, which causes Kaposi ..
  43. Structures of the portal vertex in dsDNA viruses and virus-infected cells
    Wah Chiu; Fiscal Year: 2011
    ..Our technical approaches and biological insights will be transformative in the study of viruses, not only in biochemically purified states, but also in their native cellular environments. ..
  44. T-cell immunity to polyomavirus infection
    ARON LUKACHER; Fiscal Year: 2013
    ..Aim 3: To define molecular differences between MPyV-specific memory T cells recruited during acute and persistent infection. ..
  45. Genome packaging in DNA viruses
    Liang Tang; Fiscal Year: 2013
    ....
  46. TorsinA and Nuclear Envelope Function in HSV Infection
    Richard J Roller; Fiscal Year: 2013
    ..We will test both of these hypotheses using a combination of genetic and biochemical approaches. ..
  47. TK-based Infection Imaging
    Martin G Pomper; Fiscal Year: 2013
    ....
  48. Inhibition of HCMV genome maturation by the halogenated benzimidazole, BDCRB
    Anne Sauer; Fiscal Year: 2009
    ..The current available antivirals target viral DNA synthesis, which can cause cross-resistance when treating patients. ..
  49. EARLY EVENTS IN HERPES SIMPLEX VIRUS ENTRY
    Roselyn J Eisenberg; Fiscal Year: 2012
    ..My research may suggest new treatments to stop the virus from gaining entry into its favorite target cells. ..
  50. MECHANISMS OF DNA REPLICATION AND RECOMBINATION IN HSV-1
    Paul E Boehmer; Fiscal Year: 2010
    ..They will also increase our overall knowledge of fundamental mechanisms in replication and recombination. ..
  51. Alpha-Herpesvirus Transport on Axons
    Gregory Allan Smith; Fiscal Year: 2013
    ..This proposal focuses on understanding the cellular mechanisms used by herpesviruses to spread within the nervous system and cause disease, with the long term goal of developing new treatments to intervene with disease progression. ..
  52. HERPESVIRUSES AS VACCINE VECTORS FOR AIDS
    David M Knipe; Fiscal Year: 2010
    ..Cellular assays will include ELISPOT, intracellular cytokine staining, and 10-color flow cytometry. Antibody assays will include ELISA and neutralization assays for SIV and HSV. ..
  53. Interferon Alpha Regulation of Murine Gammaherpesvirus Latency
    Erik S Barton; Fiscal Year: 2013
    ....
  54. Mechanisms of Fatigue in a Chronic Viral Disease
    Linda A Toth; Fiscal Year: 2012
    ..Such a long-term result would improve the quality of life and economic welfare of target populations that span many disease conditions. ..
  55. Can persistent gamma-herpesviruses be purged from the host?
    Marcia A Blackman; Fiscal Year: 2010
    ..The data generated will advance the field by enhancing our understanding of gamma-herpesvirus latency to facilitate the development of therapeutic strategies for the human gamma-herpesviruses. ..
  56. MOLECULAR ASPECTS OF CYTOMEGALOVIRUS LATENCY
    Jay A Nelson; Fiscal Year: 2013
    ..We hypothesize that HCMV miRNA repression of viral replication is related to NFkB activation through the IL-1 and TNF-[unreadable] pathways. ..
  57. Varicella-Zoster Virus Encapsidation Proteins
    Robert J Visalli; Fiscal Year: 2010
    ..functional properties of proteins involved in the process of DNA cleavage and packaging for VZV, and for the Herpesviridae in general...
  58. Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug Targeting
    Donald Coen; Fiscal Year: 2009
    ..This assay will be used to screen libraries of small molecules and natural products. "Hits" will be assayed for specificity, and for anti-HCMV activity and cytotoxicity, and then studied for their mechanisms of action. ..
  59. MOLECULAR CHARACTERIZATION OF HERPES SIMPLEX VIRUS ICP27
    Stephen A Rice; Fiscal Year: 2013
    ..It is also possible that these studies will lead to novel strategies for therapeutic modalities to prevent or treat herpesvirus infections. ..
  60. Study of the structure, function and regulation of gB, the fusion protein of HSV
    Roselyn J Eisenberg; Fiscal Year: 2013
    ..Our work has strong clinical significance, as each step in the fusion pathway is a potential target for therapeutics and vaccines against HSV-mediated disease. ..
  61. HIV-1: microRNA interactions
    Bryan R Cullen; Fiscal Year: 2013
    ..This research has the potential to not only shed new light on HIV-1 pathogenesis but also suggest new approaches to inhibit virus replication. ..
  62. Alpha-herpevirus assembly egress and viral particle heterogeneity
    Gregory Allan Smith; Fiscal Year: 2013
    ..This proposal focuses on understanding the molecular mechanisms that underlie the assembly and egress of herpesvirus particles, with the long- term goal of identifying new targets for the intervention of disease progression. ..
  63. SEVENTEENTH INTERNATIONAL HERPESVIRUS WORKSHOP
    S Hayward; Fiscal Year: 1992
    ....
  64. 26th Intl Herpesvirus Workshop, Regensburg, Germany
    Jay Nelson; Fiscal Year: 2001
    ..entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy, ..
  65. CMV ACCESSORY GENES AND RETINAL CELL INFECTION
    Lenore Pereira; Fiscal Year: 1999
    ..Findings of these studies will have far-reaching implications for understanding pathogenic mechanisms of herpesviruses and form a foundation for developing novel strategies to arrest cell-cell spread of retinal herpesvirus infections. ..
  66. International Herpesvirus Workshop, Cairns, Australia
    Jay Nelson; Fiscal Year: 2002
    ..abstract_text> ..
  67. 25TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay Nelson; Fiscal Year: 2000
    ....
  68. DEFINING PRIMARY HHV-6 AND HHV7 INFECTIONS IN CHILDREN
    Danielle Zerr; Fiscal Year: 2003
    ..These studies will also give me the opportunity to develop the required skills to perform clinical research and to reach my long term goal; to become an independent investigator in an academic institution. ..
  69. 24TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Frederick Wang; Fiscal Year: 1999
    ..abstract_text> ..
  70. ASSEMBLY OF THE HERPES SIMPLEX VIRUS CAPSID
    Jay Brown; Fiscal Year: 2007
    ..Studies will also be performed to identify how components of the DNA packaging machinery are assembled on the capsid surface prior to their functining in DNA translocation (aim 4). ..
  71. PF-8 AND POL-8 OF KSHV AS TARGETS OF VIRAL DNA SYNTHESIS
    Robert Ricciardi; Fiscal Year: 2001
    ..All of the inhibitors that block PF-8/Pol-8 DNA synthesis in vitro will be tested for their abilities to block KSHV infection. ..
  72. The BCL-2 Homologues of Gamma Herpesviruses
    J Marie Hardwick; Fiscal Year: 2006
    ..In Aim 3, the expression patterns of BHRF1 and BALF1 during virus infections will be explored by inserting tags into the their reading frames within the Epstein-Barr virus genome. ..
  73. ONCOGENE ACTIVATION IN B AND T LYMPHOCYTES
    Hsing Jien Kung; Fiscal Year: 2000
    ..The results from these studies should have implications beyond the avian system and provide fundamental knowledge about retroviral replication, oncogenesis as well as cell regulation. ..
  74. Tumor-Associated Herpesviruses Conference
    Nancy Raab Traub; Fiscal Year: 2006
    ..Recognize and encourage young investigators and 3. Highlight new developments in the field and identify areas for future investigation. ..