Summary: A plant genus of the family RANUNCULACEAE that contains triterpenoid saponins. Remifemin from C. racemosa is used to suppress LUTEINIZING HORMONE. It is reclassified by some to ACTAEA. The common name of black snakeroot is also used with ASARUM and SANICULA.
Publications169 found, 100 shown here
- Muscle damage induced by black cohosh (Cimicifuga racemosa)P L Minciullo
Department of Human Pathology, Division and School of Allergy and Clinical Immunology, University of Messina, Italy
Phytomedicine 13:115-8. 2006Extracts of black cohosh (Cimicifuga racemosa) are commonly used for the treatment of symptoms associated with menopause. Adverse events with black cohosh are rare, mild and reversible...
- Black cohosh does not exert an estrogenic effect on the breastRachel L Ruhlen
Department of Surgery, University of Missouri Columbia, Columbia, MO 65212, USA
Nutr Cancer 59:269-77. 2007..Triterpene content in commercially available black cohosh preparations varies. BCE standardized to 2.5% triterpenes relieved menopausal symptoms without systemic or breast-specific estrogenic effects...
- Dichloromethane fraction of Cimicifuga heracleifolia decreases the level of melanin synthesis by activating the ERK or AKT signaling pathway in B16F10 cellsJi Yeon Jang
Department of Oriental Medicine, College of Oriental Medicine, Dongeui University, Busan, South Korea
Exp Dermatol 18:232-7. 2009b>Cimicifuga rhizoma has long been used in traditional Korean medicine...
- Cycloartane triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathwayZhong Ze Fang
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
Phytother Res 25:17-24. 2011..study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including ..
- Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1Barbara A Pockaj
Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
J Clin Oncol 24:2836-41. 2006..Hot flashes can cause significant morbidity in postmenopausal women undergoing or finished with breast cancer treatment. Black cohosh has been used to treat hot flashes, but definitive clinical data about efficacy have been equivocal...
- First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055Karel Raus
Department of Obstetrics and Gynecology, Charles University Teaching Hospital, Prague, Czech Republic
Menopause 13:678-91. 2006To investigate endometrial safety by assessment of endometrial biopsy samples and the tolerability and efficacy of the special Actaea or Cimicifuga racemosa extract (CR BNO 1055).
- Estrogen-like effect of a Cimicifuga racemosa extract sub-fraction as assessed by in vivo, ex vivo and in vitro assaysP Bolle
Department of Human Physiology and Pharmacology, University La Sapienza Ple Aldo Moro, 5 00185 Rome, Italy
J Steroid Biochem Mol Biol 107:262-9. 2007Black cohosh (Cimicifuga racemosa) is used in the treatment of painful menstruation and menopausal symptoms...
- Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled studyWolfgang Wuttke
Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynaecology, University of Gottingen, Germany
Menopause 13:185-96. 2006In this study, the effects of the Cimicifuga racemosa (CR) preparation CR BNO 1055 on markers of bone metabolism, hormones, sex hormone-binding globulin (SHBG), lipometabolism, vaginal maturity, and routine laboratory parameters were ..
- Three cycloartane glycosides from Cimicifuga rhizome and their immunosuppressive activities in mouse allogeneic mixed lymphocyte reactionMakiko Nishida
Faculty of Engineering, Kyushu Kyoritsu University, Kitakyushu, Japan
Chem Pharm Bull (Tokyo) 51:354-6. 2003..3), were isolated from a commercial Cimicifuga Rhizome...
- Immunosuppressive effects of new cyclolanostane triterpene diglycosides from the aerial part of Cimicifuga foetidaRui Le Pan
Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
Arch Pharm Res 32:185-90. 2009..cimifoetiside A (1) and cimifoetiside B (2), were isolated from an 80% ethanolic extract of the aerial part of Cimicifuga foetida L. (Ranuculaceae)...
- A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's healthH Xu
UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois at Chicago, Chicago, Illinois, USA
Phytomedicine 9:757-62. 2002..The test materials included samples from three species each of the genera Cimicifuga (Actaea) and Trifolium, as well as samples of Vitex agnus-castus L., Glycyrrhiza glabra L., Gingko biloba L...
- Evaluation of the antiosteoporotic potential of Cimicifuga heracleifolia in female miceByung Su Ahn
College of Veterinary Medicine, Chonnam National University, Gwangju, 500 757, South Korea
Phytother Res 26:663-8. 2012Cimicifugae rhizoma might be protective against osteoporosis. This study investigated the effects of Cimicifuga heracleifolia (CH), an Asian species of Cimicifugae rhizome, on bone loss in ovariectomized (OVX) mice...
- Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatomaZe Tian
Children s Hospital Informatics Program at Harvard MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
BMC Cancer 7:237. 2007..Some of the cycloartane triterpenoids isolated from the aerial part of Cimicifuga dahurica showed cytotoxicity in several cancer cell lines...
- Cutaneous pseudolymphoma induced by Cimicifuga racemosaS Meyer
Department of Dermatology, University of Regensburg, Regensburg, Germany
Dermatology 214:94-6. 2007..had been taking Remifemin(R), a phytotherapeutical agent containing a standardized extract of black cohosh (Cimicifuga racemosa) rhizome for 1 year...
- In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh)Benjamin M Johnson
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
Chem Res Toxicol 16:838-46. 2003Botanical dietary supplements containing Cimicifuga racemosa (Actaea racemosa; black cohosh) are used commonly by women to assuage menopausal symptoms including hot flashes and sleep disorders...
- Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophagesCindy L H Yang
Molecular Chinese Medicine Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
J Med Chem 52:6707-15. 2009b>Cimicifuga species have been used as traditional medicinal herbs to treat inflammation and symptoms associated with menopause in Asia, Europe, and North America...
- Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7Friedemann Gaube
Institute of Pharmacy, Department of Pharmaceutical Biology, University of Jena, Semmelweisstr, 10, 07743 Jena, Germany
BMC Pharmacol 7:11. 2007Extracts from the rhizome of Cimicifuga racemosa (black cohosh) are increasingly popular as herbal alternative to hormone replacement therapy (HRT) for the alleviation of postmenopausal disorders...
- Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptomsGail B Mahady
Department of Pharmacy Practice, UIC NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, Illinois 60612, USA
Treat Endocrinol 4:177-84. 2005..Black cohosh (Actaea racemosa, syn. Cimicifuga racemosa) is one such alternative that has been used in the US for over 100 years...
- Hepatic effects of Cimicifuga racemosa extract in vivo and in vitroS Lude
Division of Clinical Pharmacology and Toxicology and Department of Research, University Hospital Basel, CH 4031 Basel, Switzerland
Cell Mol Life Sci 64:2848-57. 2007Extracts of Cimicifuga racemosa are used frequently for menopausal complaints. Cimicifuga is well tolerated but can occasionally cause liver injury. To assess hepatotoxicity of cimicifuga in more detail, ethanolic C...
- Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patientsRishma Walji
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada
Support Care Cancer 15:913-21. 2007..This paper will present the results of a systematic review of the safety and efficacy of black cohosh (Cimicifuga racemosa [L.] Nutt.) in patients with cancer.
- Black cohosh and St. John's wort for climacteric complaints: a randomized trialRalf Uebelhack
Clinic of Psychiatry, Clinic of Gynecology and St Gertrauden Krankenhaus, University Hospital Charité of the Humboldt University, Berlin, Germany
Obstet Gynecol 107:247-55. 2006To investigate the efficacy of the fixed combination of black cohosh (Cimicifuga racemosa) and St. John's wort (Hypericum perforatum) extracts in women with climacteric complaints with a pronounced psychological component.
- Petasiphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaPHubertus Jarry
Division of Clinical and Experimental Endocrinology, University of Gottingen, Gottingen, Germany
Planta Med 73:184-7. 2007Extracts of Cimicifuga racemosa (L.) Nutt. (syn.: Actaea racemosa L.) (CR) inhibit the proliferation of the human prostate cancer cell line LNCaP...
- The safety of black cohosh (Actaea racemosa, Cimicifuga racemosa)Alyson Huntley
Universities of Exeter and Plymouth, Complementary Medicine, Peninsula Medical School, 25 Victoria Park Road, Exeter, EX2 4NT, UK
Expert Opin Drug Saf 3:615-23. 2004Black cohosh (Actaea racemosa/Cimicifuga racemosa) is a North American perennial plant that has been used for traditional medicinal purposes by the native Indian population...
- Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapyV Beck
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
J Steroid Biochem Mol Biol 84:259-68. 2003Extracts from red clover (Trifolium pratense), soybean (Glycine max.) and black cohosh (Cimicifuga racemosa) are frequently used as alternative compounds for hormone replacement therapy (HRT) to treat menopausal disorders...
- Cimicifuga racemosa extract inhibits proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of apoptosisK Hostanska
Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
Breast Cancer Res Treat 84:151-60. 2004Hormone replacement therapy is contraindicated in women with breast cancer. Extracts from the rhizomes of Cimicifuga racemosa, have gained acceptance as a natural alternative for the treatment of menopausal symptoms...
- Black cohosh: just another phytoestrogen?Volker Viereck
Department of Obstetrics and Gynecology, Georg August University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
Trends Endocrinol Metab 16:214-21. 2005..Furthermore, several studies suggest that A. racemosa extracts might help control psychic problems typically found during menopausal transition...
- Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cellsLinda Saxe Einbond
Herbert Irvign Comperhensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Breast Cancer Res Treat 83:221-31. 2004..Further studies are in progress to identify the mechanisms by which actein and related compounds present in black cohosh inhibit growth of human breast cancer cells...
- Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa (Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophagesDiethart Schmid
Institute for Physiology, Section of Vegetative Physiology, Center for Physiology and Pharmacology, Medical University of Vienna, Austria
J Pharm Pharmacol 61:1089-96. 2009b>Cimicifuga racemosa (Actaea racemosa, black cohosh) is used as an anti-inflammatory, antipyretic and analgesic remedy in traditional medicines. The present study focuses on the effects of C...
- Inhibition of mast cell-dependent allergy reaction by extract of black cohosh (Cimicifuga racemosa)Chang Deok Kim
Oriental Hospital, Oriental Medical College of Daejeon University, Daejeon, South Korea
Immunopharmacol Immunotoxicol 26:299-308. 2004Black cohosh (Cimicifuga racemosa) has been used as therapeutics for pain and inflammation in Korean folk medicine...
- Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cellsKatarina Hostanska
Department of Internal Medicine F GEL 102, University Hospital Zurich, Switzerland
Biol Pharm Bull 27:1970-5. 2004..In addition, TTG and CAE compounds significantly contributed to its apoptotic effect, CAE being the more potent inhibitor of proliferation and apoptosis inducer...
- Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extractJohannes Freudenstein
Schaper and Brümmer GmbH and Co KG, D 38259 Salzgitter, Germany
Cancer Res 62:3448-52. 2002b>Cimicifuga racemosa (CR) is widely used in the treatment of menopausal symptoms. Mechanistic studies suggest that unlike hormone-replacement therapy, CR does not stimulate estrogen-receptor positive breast cancer cells...
- In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortexHye Young Kim
Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea
J Clin Virol 41:122-8. 2008..A search for new anti-coronaviral drugs to treat coronaviral infections was motivated by an outbreak of severe acute respiratory syndrome (SARS)...
- Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiolRossella E Nappi
Department of Obstetrics and Gynecology, IRCCS S Matteo, University of Pavia, Pavia, Italy
Gynecol Endocrinol 20:30-5. 2005To investigate, in a randomized clinical study, the efficacy of an isopropanolic aqueous extract of Cimicifuga racemosa (CR) on climacteric complaints in comparison with low-dose transdermal estradiol (TTSE2)...
- Influence of Cimicifuga racemosa on the proliferation of estrogen receptor-positive human breast cancer cellsCornelia Bodinet
Research and Development Department, Schaper and Brümmer GmbH and Co KG, Salzgitter, Germany
Breast Cancer Res Treat 76:1-10. 2002..To determine the influence of one such alternative, black cohosh (Cimicifuga racemosa [CR]), on estrogen-dependent mammary cancers, we conducted an in vitro investigation of the effect of ..
- Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principlesJoanna E Burdette
Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Agric Food Chem 50:7022-8. 2002The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism of action...
- Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh productsKan He
Department of Research and Development, Naturex Pure World Botanicals, Inc, 375 Huyler Street, South Hackensack, NJ 07606, USA
J Chromatogr A 1112:241-54. 2006..It is manufactured from roots and rhizomes of Cimicifuga racemosa (Ranunculaceae)...
- Cytotoxicity of three cycloartane triterpenoids from Cimicifuga dahuricaZe Tian
Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, People s Republic of China
Cancer Lett 226:65-75. 2005..In addition, inhibition of cdc2 protein expression correlates with mechanism of G(2)/M arrest...
- Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activityHilke Winterhoff
Institute for Pharmacology and Toxicology, Central Clinic, University of Munster, Domagkstrasse 12, 48149 Munster, Germany
Maturitas 44:S51-8. 2003Ethanolic- and isopropanolic-aqueous extracts of Cimicifuga racemosa are used for the treatment of climacteric complaints...
- The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markersW Wuttke
Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
Maturitas 44:S67-77. 2003In the present study, therapeutic effects of the Cimicifuga racemosa preparation CR BNO 1055 (Klimadynon/Menofem) on climacteric complaints, bone metabolism and endometrium will be compared with those of conjugated estrogens (CE) and ..
- Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaPH Jarry
Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
Phytomedicine 12:178-82. 2005Extracts from black cohosh (Cimicifuga racemosa, CR) exert an anti-proliferative action in human breast cancer cell cultures, which has been attributed to an anti-estrogenic effect...
- Black cohosh (Cimicifuga racemosa) for menopausal symptoms: a systematic review of its efficacyFrancesca Borrelli
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
Pharmacol Res 58:8-14. 2008..These therapies include herbal preparations such as black cohosh (Cimicifuga racemosa)...
- Phenolic esters from the rhizomes of Cimicifuga racemosa do not cause proliferation effects in MCF-7 cellsStefan Stromeier
Institute of Pharmaceutical Biology and Phytochemistry, Westfalische Wilhelms Universitat, Munster, Germany
Planta Med 71:495-500. 2005..isoferulate (cimiciphenone) were isolated from a commercially available extract of the rhizomes of Cimicifuga racemosa (L.) Nutt. (syn. Actaea racemosa L...
- Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetidaZe Tian
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, 100094, PR China
Fitoterapia 77:39-42. 2006Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines...
- Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosaDaniel S Fabricant
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Nat Prod 68:1266-70. 2005..1), together with the known compound fukinolic acid (2), was isolated from the n-BuOH-soluble fraction of Cimicifuga racemosa roots that showed 5-HT7 receptor binding activity...
- Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptorJoanna E Burdette
Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, IL 60612, USA
J Agric Food Chem 51:5661-70. 2003Extracts of the rhizome of black cohosh [Actaea racemosa L., formerly called Cimicifuga racemosa (L.) Nutt.] were evaluated for potential mechanisms of action in the alleviation of menopausal hot flashes...
- Actein and a fraction of black cohosh potentiate antiproliferative effects of chemotherapy agents on human breast cancer cellsLinda Saxe Einbond
Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
Planta Med 72:1200-6. 2006....
- Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterusD Seidlova-Wuttke
Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
Maturitas 44:S39-50. 2003..Owing to the increased risks of breast cancer and cardiovascular diseases, patients look for alternatives. Cimicifuga racemosa (CR) preparations might be an alternative, because they proved to reduce climacteric complaints as ..
- In vitro effects of the Cimicifuga racemosa extract BNO 1055Hubertus Jarry
Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynecology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
Maturitas 44:S31-8. 2003Extracts of Black cohosh (Cimicifuga racemosa or CR) have been used for the treatment of climacteric complaints since decades. Efficacy, particularly concerning neurovegetative and psychic symptoms, has been proven in clinical trials...
- Cimicifuga racemosa: a systematic review of its clinical efficacyFrancesca Borrelli
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
Eur J Clin Pharmacol 58:235-41. 2002b>Cimicifuga racemosa has long been advocated as an alternative to hormone-replacement therapy. However, recent experimental studies and a clinical trial have raised some questions on its utility...
- Effects of an isopropanolic extract of Cimicifuga racemosa on urinary crosslinks and other parameters of bone quality in an ovariectomized rat model of osteoporosisThomas Nisslein
Schaper and Brümmer, R and D Veterinary Medicine, Bahnhofstr 35, 38259 Salzgitter, Germany
J Bone Miner Metab 21:370-6. 2003..Because extracts of black cohosh are already recognized as safe and effective in the treatment of certain gynecological disorders, a longer-term clinical trial of this herbal remedy for the treatment of osteoporosis is warranted...
- Two new cyclolanostanol xylosides from the aerial parts of Cimicifuga dahuricaYong Liu
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People s Republic of China
J Nat Prod 65:1486-8. 2002From the aerial parts of Cimicifuga dahurica, two new cyclolanostanol xylosides, cimilactone A (1) and cimilactone B (2), and three known compounds were isolated...
- Pharmacological effects of Cimicifuga racemosaF Borrelli
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
Life Sci 73:1215-29. 2003b>Cimicifuga racemosa is widely employed to relieve menopause symptoms for its hormonal-like action. However, recent experimental studies have not found an estrogenic action by this plant...
- Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptorMee Ra Rhyu
Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research and Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois, Chicago, Illinois 60612, USA
J Agric Food Chem 54:9852-7. 2006..8 +/- 7.7 microg/mL. These results demonstrate for the first time that black cohosh contains active principle(s) that activate hMOR, supporting its beneficial role in alleviating menopausal symptoms...
- Chemical constituents from Cimicifuga foetidaPei Cao
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
J Asian Nat Prod Res 7:145-9. 2005From the rhizoma of Cimicifuga foetida L. (Ranunculaceae) a new chromone, 6'-hydroxylangelicain (18), has been isolated together with 20 known compounds...
- Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cellsLinda Saxe Einbond
Department of Rehabilitation Medicine, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, HHSC 1509, 701 W 168th Street, New York, NY 10032, USA
Phytomedicine 15:504-11. 2008..this report is to explore the growth inhibitory effect of extracts and compounds from black cohosh and related Cimicifuga species on human breast cancer cells and to determine the nature of the active components...
- Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17betaDana Seidlova-Wuttke
Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
Eur J Endocrinol 149:351-62. 2003..In the present experiments, the effects of the clinically used Cimicifuga racemosa (CR) extract BNO 1055 in the uterus, in the bone and on serum luteinizing hormone (LH) were compared ..
- Black cohosh: a cause of abnormal postmenopausal liver function testsD Joy
Locum Consultant Gastroenterologist, Prince Phillip Hospital, Llanelli, Carmarthenshire, UK
Climacteric 11:84-8. 2008..Black cohosh is commonly used for postmenopausal symptoms. We present two cases of liver toxicity related to this and recommend close monitoring of women on this herbal preparation...
- Alternative treatments of vasomotor symptoms of menopauseBaoming Ge
Ann Intern Med 147:346; author reply 347. 2007
- The Herbal Alternatives for Menopause (HALT) Study: background and study designKatherine M Newton
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
Maturitas 52:134-46. 2005..Despite inherent challenges, the study of alternative therapies for menopause symptoms is a rewarding and important area deserving of further inquiry...
- [Adverse effects of Cimicifuga]J L Schmutz
Service de Dermatologie, Hopital Fournier, 36, quai de la Bataille, 54035 Nancy Cedex, France
Ann Dermatol Venereol 135:170. 2008
- Vaginal, endometrial, and reproductive hormone findings: randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) StudySusan D Reed
Group Health Center for Health Studies, Seattle, WA, USA
Menopause 15:51-8. 2008..To evaluate vaginal, endometrial, and reproductive hormone effects of three herbal regimens compared with placebo and hormone therapy (HT)...
- The effects of black cohosh therapies on lipids, fibrinogen, glucose and insulinLeslie Spangler
Center for Health Studies, Group Health, Seattle, WA 98101, USA
Maturitas 57:195-204. 2007..Little is known about its effect on other physiologic parameters that could result in untoward events. This study examines the effect of black cohosh on lipids, fibrinogen, glucose and insulin...
- Use of alternative and complementary medicine in menopauseH J Kang
Division of Reproduction Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA
Int J Gynaecol Obstet 79:195-207. 2002..To review the clinical evidence available for the treatment of menopausal symptoms with alternative and complementary medicine...
- Cutaneous vasculitis in two patients taking an herbal supplement containing black cohoshAdam Ingraffea
J Am Acad Dermatol 56:S124-6. 2007
- Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot studyCarmela Rotem
Felsenstein Medical Research Center, Beilinson Campus, Petah Tiqva, Israel
Gynecol Endocrinol 23:117-22. 2007....
- Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trialKatherine M Newton
Group Health Center for Health Studies, The University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98101, USA
Ann Intern Med 145:869-79. 2006..Herbal supplements are widely used for vasomotor symptoms...
- Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptomsDa Jung Chung
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, 134 Sinchon dong, Seodaemun gu, Seoul, Korea
Yonsei Med J 48:289-94. 2007This study was conducted to investigate the efficacy of black cohosh (Cimicifuga racemosa) and St...
- Cimicifugae rhizoma: from origins, bioactive constituents to clinical outcomesJian Xin Li
Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing, 210093, China
Curr Med Chem 13:2927-51. 2006....
- [Complementary and alternative therapies for climacteric symptoms]Bettina Reinhard-Hennch
Ambulanz fur Naturheilkunde und Integrative Medizin, Abteilung Gynakologische Endokrinologie und Fertilitatsstorungen, Universitatsklinikum Heidelberg, Heidelberg, Deutschland
Gynakol Geburtshilfliche Rundsch 46:197-213. 2006..Review on complementary and alternative therapies for climacteric symptoms...
- Chlorination diversifies Cimicifuga racemosa triterpene glycosidesShao Nong Chen
UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Nat Prod 70:1016-23. 2007Extracts from the roots and rhizomes of black cohosh (Cimicifuga racemosa) are widely used as dietary supplements to alleviate menopausal symptoms...
- Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trialMesut Oktem
Department of Obstetrics and Gynecology, Baskent University, School of Medicine, Maltepe, Ankara, Turkey
Adv Ther 24:448-61. 2007..Compared with fluoxetine, black cohosh is more effective for treating hot flushes and night sweats. On the other hand, fluoxetine is more effective in improvements shown on Beck's Depression Scale...
- Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tiboloneWenpei Bai
The First Hospital of Peking University, Department of Gynecology, Beijing, China
Maturitas 58:31-41. 2007To investigate the efficacy-safety balance of the isopropanolic extract of Actaea (=Cimicifuga) racemosa (iCR, Remifemin) in comparison with tibolone in Chinese women with climacteric complaints.
- Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based reviewDeepti Cheema
Royal Worcestershire Hospital, Worcester, UK
Arch Gynecol Obstet 276:463-9. 2007..Interest in non-hormonal therapies for the treatment of menopausal symptoms has increased since the publication of adverse effects of estrogen replacement therapy...
- [Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials]Wiesław Maciej Kanadys
Poradnia Ginekologiczno Połoznicza Przychodni Specjalistycznej NZOZ Specjalistyka Czechów w Lublinie
Ginekol Pol 79:287-96. 2008..The following paper reviews professional literature about Black Cohosh (Actaea/Cimicifuga racemosa), either used alone or in combination with other medicinal herbs administered in management of ..
- Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trialS Frei-Kleiner
Institute of Pharmaceutical Biology, University of Basel, Switzerland
Maturitas 51:397-404. 2005..To compare the efficacy and safety of the black cohosh root extract Cr 99 with placebo in women with climacteric complaints...
- Treating hot flushes without hormone replacement therapyMachelle M Seibel
University of Massachusetts School of Medicine, Worcester, USA
J Fam Pract 52:291-6. 2003
- Definitive statements should only be made with evidenceBruce Bonde
Am Fam Physician 70:1448, 1450; author reply 1450-1. 2004
- Clinical inquiries. What nonhormonal therapies are effective for postmenopausal vasomotor symptoms?Dan Brewer
Department of Family Medicine, University of Tennessee Knoxville, USA
J Fam Pract 52:324-5, 329. 2003
- Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom reliefTieraona Low Dog
1Integrative Medicine Education Associates, Corrales, NM, and 2Innovative Science Solutions, LLC, Morristown, NJ 87048, USA
Menopause 10:299-313. 2003This comprehensive review examines the safety of Cimicifuga racemosa for the treatment of menopause symptoms, particularly in populations in which conventional menopause treatment regimens, including estrogen replacement, are ..
- [Phytotherapy in menopausal symptoms]Rüdiger Osmers
Fachabteilung Frauenheilkunde, Städt Krankenhaus Hildesheim GmbH
Pharm Unserer Zeit 33:384-91. 2004
- Influence of marketed herbal menopause preparations on MCF-7 cell proliferationCornelia Bodinet
Schaper and Brümmer GmbH and Co KG, Research and Development Department, Salzgitter, Germany
Menopause 11:281-9. 2004....
- Herbal & dietary supplements for hot flashes: here's what works--and what doesn'tMarcia Phillips
Rush University College of Health Sciences, IL, Chicago, USA
AWHONN Lifelines 7:414-20. 2003
- Alternatives to estrogenLorraine A Fitzpatrick
Endocrine Research Unit, Department of Endocrinology, Diabetes, Metabolism, Nutrition and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Med Clin North Am 87:1091-113, x. 2003..This article reviews the challenges and problems with the use of alternative medicines, and the clinical trials that prove their efficacy, and discusses the safety issues that may occur with these types of products...
- Drug-herb interactions with herbal medicines for menopauseAlyson Huntley
Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, UK
J Br Menopause Soc 10:162-5. 2004..This article outlines the major known and theoretical drug-herb interactions of herbal medicines thought to be of benefit for menopausal symptoms, as well as discussing the implications for the medical profession...
- Phytoestrogens for hormone replacement therapy?W Wuttke
Department of Clinical and Experimental Endocrinology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
J Steroid Biochem Mol Biol 83:133-47. 2002..In the urogenital tract, including the vagina, soy and red clover derived isoflavones are without effects. Cimicifuga racemosa extracts are traditionally used for the treatment of climacteric complaints...
- Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancerGerardo Hernández Muñoz
Centro Clínico de Maternidad Leopoldo Aguerrevere, Av Rio Manapire, Parque Humboldt, Prados del Este, Caracas, Venezuela
Maturitas 44:S59-65. 2003To examine the effect of Cimicifuga racemosa (CR BNO 1055) on hot flushes caused by tamoxifen adjuvant therapy in young premenopausal breast cancer survivors. This treatment presents an off-label use of CR BNO 1055.
- Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind studyMarieke O Verhoeven
Project Ageing Women, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
Menopause 12:412-20. 2005To investigate the effects of a novel dietary supplement containing soy isoflavones and Actaea racemosa Linnaeus (formerly called Cimicifuga racemosa L.) on climacteric symptoms in healthy perimenopausal women.
- The effects of remifemin on subjective symptoms of menopauseGabor Vermes
2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
Adv Ther 22:148-54. 2005..in subjective symptoms of menopause in 2016 Hungarian women who had been treated with an isopropanol extract of Cimicifuga racemosa (black cohosh). The inclusion criteria were age (40-65 y)...
- Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraineBriant E Burke
Research Service, Department of Veterans Affairs Medical Center, Boise, ID 83702, USA
Biomed Pharmacother 56:283-8. 2002..3 +/- 2.4 (mean +/- s.e.m.) in placebo treated patients to 4.7 +/- 1.8 (P < 0.01) in patients treated with the phytoestrogen preparation...
- Morning/evening menopausal formula relieves menopausal symptoms: a pilot studyJidong Sun
Enzymatic Therapy, Inc, Green Bay, WI 54311, USA
J Altern Complement Med 9:403-9. 2003....
- [Pharmacologic and clinical studies using Cimicifuga racemosa in climacteric complaints]H Winterhoff
Institut für Pharmakologie und Toxikologie des Universitätsklinikums Münster, Deutschland
Wien Med Wochenschr 152:360-3. 2002..These complaints are usually treated with estrogens, but extracts of Cimicifuga racemosa are used for this indication, too...
- The growth inhibitory activity of the Cimicifuga racemosa extract Ze 450 is mediated through estrogen and progesterone receptors-independent pathwaysMarcela Garita-Hernandez
Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Cordoba, Spain
Planta Med 72:317-23. 2006Despite the wide use of Cimicifuga racemosa (CR) extract to treat symptoms associated with menopause and other gynecological disorders, very little is known about its mechanism of action...
- Black cohosh: an alternative therapy for menopause?Gail B Mahady
UIC NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois, Chicago, Illinois, USA
Nutr Clin Care 5:283-9. 2002..One such alternative is black cohosh (Actaea racemosa, syn. Cimicifuga racemosa), which has been used in the United States for the treatment of gynecologic complaints for more than ..
- Botanicals' effect on menopausal symptomsJulia Wilson
Planned Parenthood Federation of America, New York, NY, USA
Holist Nurs Pract 18:274. 2004
- Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?Wolfgang Wuttke
Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
Maturitas 44:S9-20. 2003..from the literature as well as own results of effects of soy, red clover and their isoflavones as well as of the Cimicifuga racemosa extract BNO 1055...
- Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: a comparison using a sequential three-solvent extraction processKen Wojcikowski
Molecular and Cellular Pathology, School of Medicine, University of Queensland, Brisbane, Queensland, Australia
J Altern Complement Med 13:103-9. 2007..The prevalence of chronic renal disease exceeds 10% in industrialized societies. Oxidative damage is thought to be one of the main mechanisms involved in nearly all chronic renal pathologies...
- The Cimicifuga racemosa special extract BNO 1055 prevents hot flashes in ovariectomized ratsPriya Kapur
Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand, India
Phytomedicine 17:890-4. 2010..Need therefore arises to search for non-estrogenic alternatives. It is well established that extracts of Cimicifuga racemosa (CR) ease climacteric complaints but solid animal experimental data supporting such effects are not ..
- Development of a fast and convenient method for the isolation of triterpene saponins from Actaea racemosa by high-speed countercurrent chromatography coupled with evaporative light scattering detectionSerhat Sezai Cicek
Institute of Pharmacy Pharmacognosy, University of Innsbruck, Innsbruck, Austria
Planta Med 76:467-73. 2010..9 mg). Purity of the isolated substances was 96.8 %, 96.2 %, 97.9 %, and 98.4 %, respectively. The same method was suitable for the purification of actein and 23-epi-26-deoxyactein, with purities of 97.0 % and 98.3 %...
- Phytoestrogens in botanical dietary supplements: implications for cancerColleen E Piersen
UIC NIH Center for Botanical Dietary Supplements Research in the Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois at Chicago, College of Pharmacy, 60612, USA
Integr Cancer Ther 2:120-38. 2003..The review will focus on 5 popular botanical dietary supplements: Trifolium pratense (red clover), Cimicifuga racemosa (black cohosh), Humulus lupulus (hops), Angelica sinensis (dong quai), and Glycyrrhiza glabra (licorice)..
- Analysis of terpene compounds in Cimicifuga foetida L. by reversed-phase high-performance liquid chromatography with evaporative light scattering detectionL Kong
National Chromatographic R and A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 161 Zhongshan Road, Dalian 116011, China
J Chromatogr A 936:111-8. 2001..Actein, 27-deoxyactein and cimicifugoside in a typical Chinese medicine of Cimicifuga foetida L. were quantitatively analyzed...
- [Herbal medicine in womens' life cycle]Eran Ben-Arye
The Complementary and Traditional Medicine Unit, Department of Family Medicine, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Harefuah 145:738-42, 782. 2006..agnus) in the treatment of PMS, Ginger (Zingiber officinale) in the treatment of hyperemesis gravidarum and (Cimicifuga racemosa) in the treatment of menopausal hot flushes...
- Serotonergic Botanicals for Menopausal TreatmentSHARLA POWELL; Fiscal Year: 2009..b>Cimicifuga racemosa (Black Cohosh), Angelica sinensis (Dong Quai), and Valerian officinalis (Valerian) have all proven ..
- Botanicals for Treatment of DepressionGREGORY THATCHER; Fiscal Year: 2006..A long term goal of the project, is the development of an in vitro screen for identifying antidepressant botanicals. ..
- A NEW CULTIVATION SYSTEM FOR CLEAN CONSISTENT ROOT CROPSANITA HAYDEN; Fiscal Year: 2004..Urtica dioica), purple coneflower (Echinacea purpurea), yerba mansa (Anemopsis califomica), and black cohosh (Cimicifuga racemosa)...
- DNA and Phytochemical Fingerprinting of Actaea SpeciesEdward Kennelly; Fiscal Year: 2007Black cohosh (Actaea racemosa, syn. Cimicifuga racemosa) is a popular dietary supplement and currently one of the most promising alternative approaches to hormone replacement therapy for menopausal women...
- Beta-amyloid 1-42 lowering agent for Alzheimer's DiseaseMARK FINDEIS; Fiscal Year: 2006..This compound will be of interest for other neurological disorders where Ap-related toxicity may be a contributing factor. [unreadable] [unreadable]..
- Anticancer Potential of Black Cohosh on Breast CancerLINDA EINBOND; Fiscal Year: 2007..Black cohosh, Actaea racemosa L. (= Cimicifuga racemosa), is a North American perennial in the buttercup family (Ranunculaceae) used for various women's ..
- Botanicals from Central America for MenopauseGail Mahady; Fiscal Year: 2005..Successful validation and standardization of traditional plant-based medicines used to treat menopause has great significance not only for the women of Central America but the rest of the world as well. ..
- Botanicals for Chlamydia pneumonia infections-Revision 1Gail Mahady; Fiscal Year: 2005..Data and active standardized extracts developed during this work will be used as the basis for future clinical trials. ..
- HRT Decision Making in the Post-WHI EraKatherine Newton; Fiscal Year: 2006..This study will provide key information about HRT decision making, and experiences with HRT discontinuation, in an era of increased scientific clarity about HRT's risks and benefits. [unreadable] [unreadable]..
- Conference on Emerging Research TechnologiesGail Mahady; Fiscal Year: 2004....
- Clinical Assessment of Herb-Drug InteractionsBill Gurley; Fiscal Year: 2005..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
- ALTERNATIVE THERAPIES FOR MENOPAUSE: A RANDOMIZED TRIALKatherine Newton; Fiscal Year: 2004....
- EVALUATION OF BOTANICALS FOR H .PYLORI INFECTIONSGail Mahady; Fiscal Year: 2002..pylori strains. Active extracts will be utilized for in vivo studies. The long-term objectives are to develop safe and effective botanical extracts for the treatment and prevention of H. pylori infections. ..
- Mechanisms of prostate cancer prevention by lycopeneRichard van Breemen; Fiscal Year: 2007..These human studies will provide vital information for the design of future clinical trials investigating the chemoprevention of prostate cancer by lycopene. [unreadable] [unreadable] [unreadable]..
- Black cohosh therapy for menopause-related anxietyJay Amsterdam; Fiscal Year: 2006..We hypothesize that Black Cohosh will result in superior QOL measures compared to placebo. ..
- MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETERRichard van Breemen; Fiscal Year: 2001..abstract_text> ..
- 2D-HPLC-Tandem Mass Spectrometer for ProteomicsRichard van Breemen; Fiscal Year: 2005..Overall, the proposed 2D mu LC-MS/MS instrument will complement the existing proteomics resources on campus and will enhance the current research of NIH-funded users by providing analytical capabilities currently unavailable on campus. ..
- HYPOTHALAMIC AGING AND MENOPAUSENancy Reame; Fiscal Year: 2001....
- Pharmacotherapy for Minor DepressionRobert Howland; Fiscal Year: 2004..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
- Multidiscipli. GCRC-Mentorship Program in Womens HealthLorraine Fitzpatrick; Fiscal Year: 2003..abstract_text> ..
- Pharmacogenetic Epidemiology of Birth Defects and CancerTimothy Rebbeck; Fiscal Year: 2004....
- VENLAFAXINE FOR HOT FLASHES FOLLOWING BREAST CANCERJANET CARPENTER; Fiscal Year: 2003..e., t-tests, linear regression, GEE, mixed model). Study findings will significantly contribute to the scientific basis of hot flash management in women following treatment for breast cancer. ..
- Estrogen Receptors and Maintenance of Lens TransparencyVicki Davis; Fiscal Year: 2005..This study will provide the gateway for future studies to investigate how exposure to various estrogens influence risk of age-related cataracts and the potential of estrogens as a therapy for cataract prevention. ..
- HPLC time-of-flight mass spectrometer for accurate mass measurementsRichard van Breemen; Fiscal Year: 2007..to natural product chemists and synthetic organic chemists in the user community who rely upon rapid analyses of their compounds in order to advance with their NIH-funded research programs [unreadable] [unreadable] [unreadable]..
- Interactions of Black Cohosh with Cancer TherapySara Rockwell; Fiscal Year: 2005DESCRIPTION (provided by applicant) Black cohosh (Cimicifuga racemosa), is a widely used herbal medicine which is often assumed to be a safe and effective natural remedy for menopausal symptoms in women who have been advised by their ..
- The Bioavilaibility of Folate in HumansRichard van Breemen; Fiscal Year: 2004..Our new LC-MS-MS assay and the use of 13C-labeled folate species will provide new and more detailed information on the uptake, metabolism, and bioavailability of folates than has been possible previously. ..
- Computerized Assessment of Cancer SymptomsJANET CARPENTER; Fiscal Year: 2005....
- Effects of Botanicals on Cognition in Midlife WomenPauline Maki; Fiscal Year: 2005..Recent findings of significant health risks associated with Prempro heighten the need for research into the effects of alternative therapies for menopausal symptoms on cognitive outcomes. ..
- SPECT Brain Imaging as a Biomarker of Major DepressionJay Amsterdam; Fiscal Year: 2007..We will compare these results to measurements of striatal DAT levels in 22 non-depressed, healthy subjects studied under similar conditions with [99mTc]TRODAT-1 SPECT on two separate occasions 8 weeks apart. ..
- Chamomile therapy for generalized anxiety disorderJay Amsterdam; Fiscal Year: 2006....