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| neisseria gonorrhoeaeSummarySummary: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA. Top Publications
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Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone
Makoto Ohnishi
National Institute of Infectious Diseases, Tokyo, Japan
Antimicrob Agents Chemother 55:3538-45. 2011Recently, the first Neisseria gonorrhoeae strain (H041) that is highly resistant to the extended-spectrum cephalosporin (ESC) ceftriaxone, the last remaining option for empirical first-line treatment, was isolated...Resistance of Neisseria gonorrhoeae to non-oxidative killing by adherent human polymorphonuclear leucocytes
Alison K Criss
Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Cell Microbiol 11:1074-87. 2009Symptomatic infection with Neisseria gonorrhoeae (Gc) is characterized by abundant neutrophil (PMN, polymorphonuclear leucocyte) influx, but PMNs cannot clear initial infection, indicating that Gc possess defences against PMN challenge...An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae
Laty A Cahoon
Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
Science 325:764-7. 2009..We identified a cis-acting DNA sequence near the antigenically variable pilin locus of the human pathogen, Neisseria gonorrhoeae. This 16-base pair guanine (G)-rich sequence was required for pilin Av and formed a guanine quartet (G4) ..Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
Douglas M Warner
Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, Bethesda, MD, USA
Mol Microbiol 70:462-78. 2008..These studies establish a hierarchy of mtrR locus mutations with regard to regulation of pump efflux, and suggest selection for more derepressed mutants may occur during mixed infections...Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells
Michael P Jennings
Institute for Glycomics, Griffith University, Gold Coast Campus, Australia
Cell Microbiol 13:885-96. 2011Expression of type IV pili by Neisseria gonorrhoeae plays a critical role in mediating adherence to human epithelial cells...Type IV pilus structure and bacterial pathogenicity
Lisa Craig
Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Nat Rev Microbiol 2:363-78. 2004Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection
Hong Wu
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
Infect Immun 74:4094-103. 2006The addition of host-derived sialic acid to Neisseria gonorrhoeae lipooligosaccharide is hypothesized to be an important mechanism by which gonococci evade host innate defenses...Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity
H J Tseng
Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLD 4072, Australia
Mol Microbiol 40:1175-86. 2001As a facultative aerobe with a high iron requirement and a highly active aerobic respiratory chain, Neisseria gonorrhoeae requires defence systems to respond to toxic oxygen species such as superoxide...Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
W M Shafer
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 95:1829-33. 1998..capacity of protegrin-1 (PG-1), a cysteine-rich, cationic peptide from porcine leukocytes, against Neisseria gonorrhoeae. We now report genetic and biochemical evidence that gonococcal susceptibility to the lethal action of PG-..Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways
Mingfeng Liu
Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, CA, 94121, USA
J Immunol 185:6974-84. 2010..Our findings are consistent with the concept that bacteria modulate pathogen-associated molecular patterns by expression of phosphoryl moieties on the LA to optimize interactions with the host...UK national guideline for the management of gonorrhoea in adults, 2011
C Bignell
Nottingham University Hospitals NHS Trust, Nottingham, UK
Int J STD AIDS 22:541-7. 2011..The aim is to slow the spread of resistant gonorrhoea now that fewer antibiotics remain effective. A patient information leaflet has been developed...Women find it easy and prefer to collect their own vaginal swabs to diagnose Chlamydia trachomatis or Neisseria gonorrhoeae infections
Max A Chernesky
St Joseph s Healthcare, Hamilton, Ontario, Canada
Sex Transm Dis 32:729-33. 2005Self-collected specimens can be used to screen asymptomatic women for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC)...A homologue of the recombination-dependent growth gene, rdgC, is involved in gonococcal pilin antigenic variation
I J Mehr
Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Genetics 154:523-32. 2000b>Neisseria gonorrhoeae pilin undergoes high-frequency changes in primary amino acid sequence that aid in the avoidance of the host immune response and alter pilus expression...Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions
Lisa Craig
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
Mol Cell 23:651-62. 2006..b>Neisseria gonorrhoeae (gonococcal or GC) T4P are prototypic virulence factors and immune targets for increasingly antibiotic-..High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure
Magnus Unemo
WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
Antimicrob Agents Chemother 56:1273-80. 2012Recently, the first Neisseria gonorrhoeae strain (H041) highly resistant to the expanded-spectrum cephalosporins (ESCs) ceftriaxone and cefixime, which are the last remaining options for first-line gonorrhea treatment, was isolated in ..Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
C A Gaydos
Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
J Clin Microbiol 48:3236-43. 2010..CT/NG assay, a multiplex real-time PCR assay, for simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae. The specimens were collected from a total of 3,832 male and female subjects at 16 geographically diverse ..Adult male circumcision does not reduce the risk of incident Neisseria gonorrhoeae, Chlamydia trachomatis, or Trichomonas vaginalis infection: results from a randomized, controlled trial in Kenya
Supriya D Mehta
Department of Epidemiology, University of Illinois at Chicago School of Public Health, Chicago, Illinois, USA
J Infect Dis 200:370-8. 2009..We examined the effect of male circumcision on the acquisition of 3 nonulcerative sexually transmitted infections (STIs)...Opacity proteins increase Neisseria gonorrhoeae fitness in the female genital tract due to a factor under ovarian control
Jessica G Cole
Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Infect Immun 78:1629-41. 2010..Opa(+) variants of Neisseria gonorrhoeae strain FA1090 are selected in a cyclical pattern from the lower genital tract of estradiol-treated mice...A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells
Jennifer L Edwards
Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
Cell Microbiol 4:571-84. 2002..In conjunction, these molecules facilitate targeting to and successful infection of the cervical epithelium...Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae
S Ram
Evans Biomedical Research Center, Boston Medical Center, Boston, Massachusetts 02118, USA
J Exp Med 193:281-95. 2001We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound the complement regulator, C4b-binding protein (C4bp)...Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae
Wendy L Veal
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Bacteriol 184:5619-24. 2002..efflux pump in conferring chromosomally mediated penicillin resistance on certain strains of Neisseria gonorrhoeae was determined by using genetic derivatives of penicillin-sensitive strain FA19 bearing defined mutations (..Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
B Feinen
Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
Mucosal Immunol 3:312-21. 2010Host immune responses, including the characteristic influx of neutrophils, against Neisseria gonorrhoeae are poorly understood; adaptive immunity is minimal and non-protective. We hypothesize that N...Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay
Kate L Seib
The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
Infect Immun 73:5269-72. 2005b>Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N...Interactions of Neisseria gonorrhoeae with adherent polymorphonuclear leukocytes
Mark P Simons
Department of Microbiology, 3 403 Bowen Science Building, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
Infect Immun 73:1971-7. 2005b>Neisseria gonorrhoeae causes severe exudative urethritis. The exudates from infected individuals contain large numbers of polymorphonuclear leukocytes (PMN) with ingested gonococci. The fate of N...Opportunity and means: horizontal gene transfer from the human host to a bacterial pathogen
Mark T Anderson
Department of Microbiology Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
MBio 2:e00005-11. 2011..fragment of the human long interspersed nuclear element L1 to the genome of the strictly human pathogen Neisseria gonorrhoeae. A 685-bp sequence exhibiting 98 to 100% identity to copies of the human L1 element was identified ..A variable genetic island specific for Neisseria gonorrhoeae is involved in providing DNA for natural transformation and is found more often in disseminated infection isolates
J P Dillard
Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
Mol Microbiol 41:263-77. 2001b>Neisseria gonorrhoeae (the gonococcus) is the causative agent of the sexually transmitted disease gonorrhoea...Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease
J Pohlner
Nature 325:458-62. 1987Several human bacterial pathogens, including the Gram-negative diplococcus Neisseria gonorrhoeae, produce extracellular proteases that are specific for human immunoglobulin IgA1...Neisseria gonorrhoeae suppresses the oxidative burst of human polymorphonuclear leukocytes
Alison K Criss
Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Cell Microbiol 10:2257-70. 2008Symptomatic infection with Neisseria gonorrhoeae (Gc) results in a potent polymorphonuclear leukocyte (PMN)-driven inflammatory response, but the mechanisms by which Gc withstands PMN attack are poorly defined...The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women
Jennifer L Edwards
Department of Microbiology, The University of Iowa, 51 Newton Rd, BSB 3 403, Iowa City, IA 52242, USA
Clin Microbiol Rev 17:965-81, table of contents. 2004..A model of gonococcal pathogenesis is presented in the context of the male and female human urogenital tracts...Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae
Vincent M Isabella
Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
BMC Genomics 12:51. 2011Maintenance of an anaerobic denitrification system in the obligate human pathogen, Neisseria gonorrhoeae, suggests that an anaerobic lifestyle may be important during the course of infection...Structure of the Vibrio cholerae Type IVb Pilus and stability comparison with the Neisseria gonorrhoeae type IVa pilus
Juliana Li
Molecular Biology and Biochemistry Department, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
J Mol Biol 418:47-64. 2012..folds, we compared the stabilities of pilin subunits and pilus filaments for the Type IVa GC pilus from Neisseria gonorrhoeae and the Type IVb toxin-coregulated pilus (TCP) from Vibrio cholerae...Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009
Supriya D Mehta
Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60622, USA
Antimicrob Agents Chemother 55:3882-8. 2011We evaluated antimicrobial resistance in Neisseria gonorrhoeae isolated from men enrolled in a randomized trial of male circumcision to prevent HIV. Urethral specimens from men with discharge were cultured for N. gonorrhoeae...Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens
Tim Schmitter
Zentrum für Infektionsforschung, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
J Exp Med 199:35-46. 2004....Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria
Laty A Cahoon
Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Mol Microbiol 81:1136-43. 2011..without deleterious effects on the genome in the well-characterized pilin antigenic variation systems of Neisseria gonorrhoeae and Neisseria meningitidis is presented...Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction
Constance M John
Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Lipid Res 50:424-38. 2009..This methodology enabled us to rapidly profile components of structural variants of native LOS that are of importance biologically...The incidence and correlates of symptomatic and asymptomatic Chlamydia trachomatis and Neisseria gonorrhoeae infections in selected populations in five countries
Roger Detels
Department of Epidemiology, UCLA School of Public Health, 71 269 CHS, Box 951772, Los Angeles, CA 90095 1772, USA
Sex Transm Dis 38:503-9. 2011Asymptomatic Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhea) infections pose diagnostic and control problems in developing countries.Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome
Joseph A Duncan
Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Immunol 182:6460-9. 2009b>Neisseria gonorrhoeae is a common sexually transmitted pathogen that significantly impacts female fertility, neonatal health, and transmission of HIV worldwide. N...Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by enzyme immunoassay, culture, and three nucleic acid amplification tests
E Van Dyck
STD HIV Research and Intervention Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
J Clin Microbiol 39:1751-6. 2001..and compare three commercially available nucleic acid amplification tests (NAATs) for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis...The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal lactobacilli during anaerobic growth
Michelle A Graver
Medical Microbiology, King s College Hospital, Denmark Hill, London, UK
Ann Clin Microbiol Antimicrob 10:8. 2011..vaginosis, normal lactobacilli are replaced by an anaerobic flora and this may increase susceptibility to Neisseria gonorrhoeae, a facultative anaerobe. Bacterial interference between vaginal lactobacilli and N...Opposing selective forces for expression of the gonococcal lactoferrin receptor
James E Anderson
Department of Medicine, School of Medicine, University of North Carolina, 521 Burnett Womack Building, CB 7030, Chapel Hill 27599, USA
Mol Microbiol 48:1325-37. 2003All isolates of Neisseria gonorrhoeae express receptors that bind human transferrin (Tf). Although lactoferrin (Lf) is abundant on mucosa and in purulent exudates, many gonococci do not express an Lf receptor...Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxide
Megan L Falsetta
Department of Microbiology, University of Iowa, 51 Newton Rd, BSB 3 403, Iowa City, IA 52242, USA
Infect Immun 78:2320-8. 2010b>Neisseria gonorrhoeae is the etiologic agent of gonorrhea, which has been among the most frequently reported communicable diseases in the United States since 1960...Spread of a chromosomal cefixime-resistant penA gene among different Neisseria gonorrhoeae lineages
Makoto Ohnishi
Department of Bacteriology, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
Antimicrob Agents Chemother 54:1060-7. 2010In Neisseria gonorrhoeae, the mosaic type of penA, which encodes penicillin-binding protein 2 (PBP 2), is associated with reduced susceptibility to oral cephalosporins. To investigate the relatedness of N...Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection
Harold C Wiesenfeld
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, PA 15213, USA
Clin Infect Dis 36:663-8. 2003..with normal vaginal flora, subjects with bacterial vaginosis were more likely to test positive for Neisseria gonorrhoeae (odds ratio [OR], 4.1; 95% confidence interval [CI], 1.7-9.7) and Chlamydia trachomatis (OR, 3...Neisseria gonorrhoeae survival during primary human cervical epithelial cell infection requires nitric oxide and is augmented by progesterone
Jennifer L Edwards
The Center for Microbial Pathogenesis, The Research Institute at Nationwide Children s Hospital and the Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
Infect Immun 78:1202-13. 2010b>Neisseria gonorrhoeae is an obligate human pathogen that causes gonorrhea. We have shown previously that complement receptor 3 and Akt kinase play important roles in mediating cervical infection...The gonococcal fur regulon: identification of additional genes involved in major catabolic, recombination, and secretory pathways
Shite Sebastian
Evans Biomedical Research Center, Department of Medicine, Section of Infectious Diseases, Boston, Massachusetts 02118, USA
J Bacteriol 184:3965-74. 2002In this study, we have characterized the in vitro binding of Neisseria gonorrhoeae Fur to several well-defined iron transport genes, as well as to additional genes involved in major catabolic, secretory, and recombination pathways of ..Thioredoxin reductase is essential for protection of Neisseria gonorrhoeae against killing by nitric oxide and for bacterial growth during interaction with cervical epithelial cells
Adam J Potter
Australian Bacterial Pathogenesis Program and Centre for Metals in Biology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, Australia
J Infect Dis 199:227-35. 2009In Neisseria gonorrhoeae, the MerR family transcription factor NmlR activates 3 operons in response to disulfide stress...The transcriptome response of Neisseria gonorrhoeae to hydrogen peroxide reveals genes with previously uncharacterized roles in oxidative damage protection
Elizabeth A Stohl
Northwestern University, Feinberg School of Medicine, Department of Microbiology Immunology, 303 E Chicago Ave, Chicago, IL 60611, USA
Mol Microbiol 58:520-32. 2005Symptomatic gonococcal infection, caused by the pathogen Neisseria gonorrhoeae (Gc), is characterized by the influx of polymorphonuclear leukocytes (PMNs) to the site of infection...Conjugative plasmids of Neisseria gonorrhoeae
Emilia Pachulec
Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
PLoS ONE 5:e9962. 2010Many clinical isolates of the human pathogen Neisseria gonorrhoeae contain conjugative plasmids...Biofilm Formation by Neisseria gonorrhoeae
L L Greiner
Department of Microbiology, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
Infect Immun 73:1964-70. 2005Studies were performed in continuous-flow chambers to determine whether Neisseria gonorrhoeae could form a biofilm. Under these growth conditions, N...Untreated gonococcal and chlamydial infection in a probability sample of adults
Charles F Turner
Program in Health and Behavior Measurement, Research Triangle Institute, 1615 M St NW, Washington, DC 20036, USA
JAMA 287:726-33. 2002..Development of nucleic acid amplification tests, such as the ligase chain reaction assay, provides new opportunities to estimate the prevalence of untreated infections in the population...The Neisseria gonorrhoeae biofilm matrix contains DNA, and an endogenous nuclease controls its incorporation
Christopher T Steichen
Department of Microbiolog, The University of Iowa, Iowa City, IA 52242, USA
Infect Immun 79:1504-11. 2011b>Neisseria gonorrhoeae has been shown to produce biofilms both in experimental flow chambers and in the human host. Our laboratory has shown that extracellular DNA is an essential component of the gonococcal matrix...Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum
Lisa A Lewis
Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts, USA
Infect Immun 77:1112-20. 2009The capacity of Neisseria gonorrhoeae to cause disseminated gonococcal infection requires that such strains resist the bactericidal action of normal human serum. The bactericidal action of normal human serum against N...Transcriptional and functional analysis of the Neisseria gonorrhoeae Fur regulon
Lydgia A Jackson
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK 73104, USA
J Bacteriol 192:77-85. 2010To ensure survival in the host, bacteria have evolved strategies to acquire the essential element iron. In Neisseria gonorrhoeae, the ferric uptake regulator Fur regulates metabolism through transcriptional control of iron-responsive ..Emergence, spread and characteristics of Neisseria gonorrhoeae isolates with in vitro decreased susceptibility and resistance to extended-spectrum cephalosporins in Sweden
Daniel Golparian
National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
Sex Transm Infect 86:454-60. 2010b>Neisseria gonorrhoeae has developed resistance to most antimicrobials used for treatment...Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses
Sandra J van Vliet
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
PLoS Pathog 5:e1000625. 2009..b>Neisseria gonorrhoeae LOS phenotype C constitutes the first bacterial ligand to be described for the human C-type lectin ..DNA uptake sequence-mediated enhancement of transformation in Neisseria gonorrhoeae is strain dependent
Paul M Duffin
Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Bacteriol 192:4436-44. 2010Natural transformation is the main means of horizontal genetic exchange in the obligate human pathogen Neisseria gonorrhoeae. Neisseria spp...The phosphorylcholine epitope undergoes phase variation on a 43-kilodalton protein in Pseudomonas aeruginosa and on pili of Neisseria meningitidis and Neisseria gonorrhoeae
J N Weiser
Departments of Pediatrics and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Infect Immun 66:4263-7. 1998..Expression of the ChoP epitope on piliated neisseriae displayed phase variation, both linked to pilus expression and independently of fully piliated bacteria...Opa+ and Opa- isolates of Neisseria meningitidis and Neisseria gonorrhoeae induce sustained proliferative responses in human CD4+ T cells
Abdel Rahman Youssef
Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
Infect Immun 77:5170-80. 2009..The data also imply that Opa-proficient vaccine preparations may not necessarily inhibit T-cell functions via CEACAM1 binding...Comparing first-void urine specimens, self-collected vaginal swabs, and endocervical specimens to detect Chlamydia trachomatis and Neisseria gonorrhoeae by a nucleic acid amplification test
Mary Ann Shafer
Division of Adolescent Medicine, Department of Pediatrics, University of California, San Francisco 94143, USA
J Clin Microbiol 41:4395-9. 2003We set out to determine the prevalences of Chlamydia trachomatis and Neisseria gonorrhoeae by ligase chain reaction as well as to determine the prevalence of Trichomonas vaginalis by culture in a large and diverse national sample of non-..Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses
Mathanraj Packiam
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
Infect Immun 78:433-40. 2010..Asymptomatic infections are also common. Information on the innate response to Neisseria gonorrhoeae in women is limited to studies with cultured cells, isolated immune cells, and analyses of cervicovaginal ..Broad spectrum O-linked protein glycosylation in the human pathogen Neisseria gonorrhoeae
Ashild Vik
Department of Molecular Biosciences and Center for Molecular Biology and Neuroscience, University of Oslo, Oslo 0316, Norway
Proc Natl Acad Sci U S A 106:4447-52. 2009..and functionally diverse groups of membrane-associated proteins in the gram-negative bacterium Neisseria gonorrhoeae, the etiologic agent of the human disease gonorrhea...Pilin gene variation in Neisseria gonorrhoeae: reassessing the old paradigms
Stuart A Hill
Department of Biological Sciences, Northern Illinois University, DeKalb, 60115, USA
FEMS Microbiol Rev 33:521-30. 2009b>Neisseria gonorrhoeae displays considerable potential for antigenic variation as shown in human experimental studies. Various surface antigens can change either by antigenic variation using RecA-dependent recombination schemes (e.g...Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment
Kate L Seib
The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
Microbiol Mol Biol Rev 70:344-61. 2006b>Neisseria gonorrhoeae is a host-adapted pathogen that colonizes primarily the human genitourinary tract...Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production
Milica Pantelic
Department of Microbiology and Immunology, Division of Infectious Diseases, Walther Oncology Center, Indiana University School of Medicine, MS415E, 635 Barnhill Dr, Indianapolis, Indiana 46202 5120, USA
Infect Immun 73:4171-9. 2005b>Neisseria gonorrhoeae cells (gonococci [GC]), the etiological agents for gonorrhea, can cause repeated infections. During and after gonococcal infection, local and systemic antigonococcal antibody levels are low...Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003
Charlotte K Kent
Department of Public Health, San Francisco, California, USA
Clin Infect Dis 41:67-74. 2005..However, in most clinical settings, rectal chlamydial testing is not performed for MSM, and primarily sexually transmitted disease (STD) clinics alone perform routine rectal and pharyngeal gonorrhea screening for asymptomatic men...Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area
Iona M C Martin
Department of Infectious Diseases and Microbiology, Imperial College London, St Mary s Campus, London, United
J Infect Dis 189:1497-505. 2004....Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs
Kirsten Mattison
Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, USA
J Biol Chem 281:37942-51. 2006b>Neisseria gonorrhoeae is a sexually transmitted pathogen that initiates infections in humans by adhering to the mucosal epithelium of the urogenital tract...Genome sequencing reveals widespread virulence gene exchange among human Neisseria species
Pradeep Reddy Marri
The BIO5 Institute, University of Arizona, Tucson, Arizona, United States of America
PLoS ONE 5:e11835. 2010..Our findings strongly suggest that commensal Neisseria serve as reservoirs of virulence alleles, and that they engage extensively in genetic exchange...High-force generation is a conserved property of type IV pilus systems
Martin Clausen
Department for Biology, Westfalische Wilhelms Universitat, Munster, Germany
J Bacteriol 191:4633-8. 2009The type IV pilus (T4P) system of Neisseria gonorrhoeae is the strongest linear molecular motor reported to date, but it is unclear whether high-force generation is conserved between bacterial species...Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
Raina N Fichorova
Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:2424-32. 2002..endocervical epithelial cells were unresponsive to protein-free preparations of lipooligosaccharide from Neisseria gonorrhoeae and LPS from Escherichia coli...Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways
Oliver Billker
Max Planck Institut für Infektionsbiologie, Abteilung Molekulare Biologie, Schumannstrasse 21 22, D 10117 Berlin, Germany
EMBO J 21:560-71. 2002..CEACAM receptors mediate opsonization-independent phagocytosis of Neisseria gonorrhoeae by human granulocytes and each receptor individually can mediate gonococcal invasion of epithelial cells...Characterization of the OxyR regulon of Neisseria gonorrhoeae
Kate L Seib
School of Molecular and Microbial Sciences and Centre for Metals in Biology, The University of Queensland, Brisbane 4072, QLD, Australia
Mol Microbiol 63:54-68. 2007..a previous study we reported the OxyR-dependent derepression of catalase expression in the human pathogen Neisseria gonorrhoeae. In the present study we used microarray expression profiling of N...The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species
Eric P Skaar
Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Searle 6 497, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 99:10108-13. 2002The PilB protein of Neisseria gonorrhoeae has been reported to be involved in the regulation of pilin gene transcription, but it also possesses significant homology to the peptide methionine sulfoxide reductase family of enzymes, ..A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
Ann E Jerse
Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Infect Immun 71:5576-82. 2003..Two well-characterized multidrug resistance efflux systems (MtrCDE and FarAB-MtrE) exist in Neisseria gonorrhoeae, a bacterial pathogen of the human genital mucosae...Local and humoral immune responses against primary and repeat Neisseria gonorrhoeae genital tract infections of 17beta-estradiol-treated mice
Wenxia Song
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
Vaccine 26:5741-51. 2008..We conclude that similar to human infection, experimental murine infection induces local inflammation but not an acquired immune response or immunological memory...Genetic diversity and mosaicism at the por locus of Neisseria gonorrhoeae
T C Fudyk
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
J Bacteriol 181:5591-9. 1999The por genes of the predominant serovars of Neisseria gonorrhoeae circulating in a high-frequency transmitter core group located in Nairobi, Kenya, were examined for nucleotide sequence polymorphism...Restriction and modification systems of Neisseria gonorrhoeae
D C Stein
University of Maryland, Department of Microbiology, College Park 20742, USA
Gene 157:19-22. 1995An individual strain of Neisseria gonorrhoeae may produce up to 16 different DNA methytransferases (MTases). We have used a novel cloning system that is able to detect MTase clones in the absence of direct selection [Piekarowicz et al...Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007
Lillian B Brown
Division of Infectious Diseases, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Sex Transm Dis 37:169-72. 2010..We sought to establish current laboratory-based Neisseria gonorrhoeae antibiotic susceptibility patterns for Malawi and describe the pattern of susceptibility since syndromic ..The effect of hfq on global gene expression and virulence in Neisseria gonorrhoeae
Manuela Dietrich
Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
FEBS J 276:5507-20. 2009..To characterize the role of Hfq in the pathogenicity of Neisseria gonorrhoeae, we generated an N. gonorrhoeae hfq mutant...Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea
Magnus Unemo
WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for Pathogenic Neisseria, Orebro University Hospital, SE 701 85 Orebro, Sweden
Future Microbiol 7:1401-22. 2012The new superbug Neisseria gonorrhoeae has retained resistance to antimicrobials previously recommended for first-line treatment and has now demonstrated its capacity to develop resistance to the extended-spectrum cephalosporin, ..An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae
Sarika Agarwal
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 185:507-16. 2010..available unfractionated properdin was shown to bind to certain biological surfaces, including Neisseria gonorrhoeae, which facilitated C3 deposition...Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian Regions, 2010
Monica M Lahra
WHO Collaborating Centre for STD, Department of Microbiology, SEALS The Prince of Wales Hospital, Randwick, New South Wales
Commun Dis Intell Q Rep 36:95-100. 2012..Surveillance Programme (GASP) has conducted continuous surveillance of antimicrobial resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region (WPR) to optimise antibiotic treatment and control of gonococcal disease ..Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations
Joshua Tomberg
Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
Biochemistry 49:8062-70. 2010..crucial for intermediate resistance to the expanded-spectrum cephalosporins ceftriaxone and cefixime in Neisseria gonorrhoeae. Three of the ∼60 mutations present in mosaic alleles of penA, G545S, I312M, and V316T, have been ..Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention
J Sobngwi-Tambekou
INSERM U687, Hopital Paul Brousse, Villejuif, France
Sex Transm Infect 85:116-20. 2009To assess the association between male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis using data from a male circumcision randomised controlled trial.Off-target gene regulation mediated by transcriptional repressors of antimicrobial efflux pump genes in Neisseria gonorrhoeae
Paul J T Johnson
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Antimicrob Agents Chemother 55:2559-65. 2011..its ability to repress transcription of the mtrCDE-encoded efflux pump operon in the strict human pathogen Neisseria gonorrhoeae, but recent results from genetic and microarray studies have shown that it can control expression of ..Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae
Helen Sarantis
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Infect Immun 80:345-58. 2012Symptomatic infection of humans with Neisseria gonorrhoeae is characterized by a neutrophil-rich cervical or urethral exudate, suggesting that neutrophils are important both for the clearance of these bacteria and for the pathogenesis of ..Neisseria gonorrhoeae type IV pili undergo multisite, hierarchical modifications with phosphoethanolamine and phosphocholine requiring an enzyme structurally related to lipopolysaccharide phosphoethanolamine transferases
Finn Erik Aas
Centre for Molecular Biology and Neuroscience, Department of Molecular Biosciences, University of Oslo, 0316 Oslo, Norway
J Biol Chem 281:27712-23. 2006..PilE, the major pilin subunit protein of the type IV pilus (Tfp) colonization factor of Neisseria gonorrhoeae undergoes unique, post-translational modifications with these moieties...Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes
Magnus Unemo
Department of Clinical Microbiology, Orebro University Hospital, Sweden
J Antimicrob Chemother 63:1142-51. 2009Emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae remain a major global problem and expanded, but valid, AMR surveillance is crucial for public health purposes...Widespread distribution in pathogenic bacteria of di-iron proteins that repair oxidative and nitrosative damage to iron-sulfur centers
Tim W Overton
School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
J Bacteriol 190:2004-13. 2008Expression of two genes of unknown function, Staphylococcus aureus scdA and Neisseria gonorrhoeae dnrN, is induced by exposure to oxidative or nitrosative stress...Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine
Meredith D Hartley
Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Biochemistry 50:4936-48. 2011The O-linked protein glycosylation pathway in Neisseria gonorrhoeae is responsible for the synthesis of a complex oligosaccharide on undecaprenyl diphosphate and subsequent en bloc transfer of the glycan to serine residues of select ..Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner
Victor H Ferreira
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON L8N 3Z5, Canada
J Infect Dis 204:299-308. 2011..Sexually transmitted infections (STIs) are associated with increased human immunodeficiency virus type 1 (HIV-1) susceptibility and viral shedding in the genital tract, but the mechanisms underlying this association are poorly understood...Home versus clinic-based specimen collection for Chlamydia trachomatis and Neisseria gonorrhoeae
Anna S Graseck
Washington University in St Louis School of Medicine, Division of Clinical Research, Department of Obstetrics and Gynecology, Campus Box 8219, 4533 Clayton Avenue, St Louis, MO 63110, USA
Expert Rev Anti Infect Ther 9:183-94. 2011..This article describes and evaluates the effectiveness and limitations of various home screening strategies used for the detection of STIs...Trends in antimicrobial resistance of Neisseria gonorrhoeae isolated from Korean patients from 2000 to 2006
Hyukmin Lee
Department of Laboratory Medicine, Kwandong University College of Medicine, Goyang, Korea
Sex Transm Dis 38:1082-6. 2011The recent emergence and spread of antimicrobial-resistant Neisseria gonorrhoeae has compromised treatment and control of gonorrhea...Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein
M Christodoulides
Molecular Microbiology Group, University of Southampton Medical School, UK
Mol Microbiol 35:32-43. 2000Infection of the endometrium by Neisseria gonorrhoeae is a pivotal stage in the development of pelvic inflammatory disease in women...Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis
Alexander Buntru
Lehrstuhl für Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
J Biol Chem 286:9555-66. 2011..CEACAM3 functions as a single chain phagocytotic receptor recognizing gram-negative bacteria such as Neisseria gonorrhoeae, which possess CEACAM-binding adhesins on their surface...Mismatch correction modulates mutation frequency and pilus phase and antigenic variation in Neisseria gonorrhoeae
Alison K Criss
Department of Microbiology Immunology, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
J Bacteriol 192:316-25. 2010..To test the functions of MMC in the obligate human pathogen Neisseria gonorrhoeae, homologues of the core MMC genes mutS and mutL were inactivated in strain FA1090...Mutations affecting peptidoglycan acetylation in Neisseria gonorrhoeae and Neisseria meningitidis
Joseph P Dillard
Department of Medical Microbiology and Immunology, University of Wisconsin Madison Medical School, 1300 University Avenue, 471A MSC, Madison, WI 53706, USA
Infect Immun 73:5697-705. 2005b>Neisseria gonorrhoeae acetylates its cell wall peptidoglycan (PG) at the C-6 position on N-acetylmuramic acid...O-acetylation of peptidoglycan in gram-negative bacteria: identification and characterization of peptidoglycan O-acetyltransferase in Neisseria gonorrhoeae
Patrick J Moynihan
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
J Biol Chem 285:13264-73. 2010The ape2 gene encoding a hypothetical O-acetylpeptidoglycan esterase was amplified from genomic DNA of Neisseria gonorrhoeae FA1090 and cloned to encode either the full-length protein or a truncated version lacking its hypothetical ..Emerging antimicrobial resistance in Neisseria gonorrhoeae: urgent need to strengthen prevention strategies
Kimberly A Workowski
National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, and Emory University, Atlanta, Georgia, USA
Ann Intern Med 148:606-13. 2008..Over the past 60 years, however, development of resistance in Neisseria gonorrhoeae to multiple antimicrobial classes challenges this component of gonorrhea control...An inhibitor of DNA binding and uptake events dictates the proficiency of genetic transformation in Neisseria gonorrhoeae: mechanism of action and links to Type IV pilus expression
Finn Erik Aas
Biotechnology Centre of Oslo, 0317 Oslo, Norway
Mol Microbiol 46:1441-50. 2002..In Neisseria gonorrhoeae, the Gram-negative aetiologic agent of gonorrhoea, DNA binding and uptake involve components required for ..Differential regulation of ponA and pilMNOPQ expression by the MtrR transcriptional regulatory protein in Neisseria gonorrhoeae
Jason P Folster
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Bacteriol 189:4569-77. 2007b>Neisseria gonorrhoeae utilizes the mtrCDE-encoded efflux pump system to resist not only host-derived, hydrophobic antimicrobials that bathe mucosal surfaces, which likely aids in its ability to colonize and infect numerous sites within ..
Research Grants
- The role of novel, uncultivable bacteria in incident PIDCATHERINE L contact HAGGERTY; Fiscal Year: 2011..Although Chlamydia trachomatis and Neisseria gonorrhoeae are commonly associated with PID, the etiology of up to 70% of cases is unknown...
- A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDsRichard F Selden; Fiscal Year: 2012DESCRIPTION (provided by applicant): Improved diagnosis of Neisseria gonorrhoeae (GC) infections represents a critical unmet medical need...
- Prophage-associated virulence factors in pathogenic Neisseria speciesANNA KARLS; Fiscal Year: 2009..identify virulence factors that may be targeted for the design of effective vaccines and therapeutics for Neisseria gonorrhoeae (gonococci, GC), which causes gonorrhoeae and pelvic inflammatory disease, and Neisseria meningitidis (..
- Gonococcal resistance to peroxynitriteVirginia L Clark; Fiscal Year: 2010DESCRIPTION: Neisseria gonorrhoeae is the causative agent of gonorrhea, one of the most prevalent infectious diseases in this country...
- Gonococcal Mechanisms to Evade Host DefensesWILLIAM MAURICE SHAFER; Fiscal Year: 2013Project Summary/ Abstract Neisseria gonorrhoeae causes both localized uncomplicated infections at mucosal surfaces and more invasive forms of disease including pelvic inflammatory disease and bloodstream infections...
- Novel Bacterial Pathogens in Pelvic Inflammatory DiseaseCatherine L Haggerty; Fiscal Year: 2012..Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are recovered from approximately a third to a half of women with PID, in the ..
- Rapid and Cost-Effective Diagnostic System for Sexually Transmitted InfectionsJohn E Mueller; Fiscal Year: 2011..by applicant): According to the CDC, chlamydia and gonorrhea, caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), respectively, are the first and second most frequently reported STIs in the US and likely the rest ..
- Computerized Counseling to Promote Positive Prevention and HIV Health in KenyaAnn Elizabeth Kurth; Fiscal Year: 2012..by self-reported unprotected sex with HIV- negative/unknown partner, and trends in Chlamydia trachomatis, Neisseria gonorrhoeae, and T. vaginalis...
- PROTEIN/LIPID INTERACTIONSRobert B Gennis; Fiscal Year: 2013..Haemophilus influenzae, for which cytochrome bd has been recently shown to be essential for growth;and 3) Neisseria gonorrhoeae, which relies on cytochrome cbb3 for aerobic growth...
- Can Sexually Transmitted Pathogens Impact the Efficacy of HIV-1 Microbicides?SUSANA NOEMI ASIN; Fiscal Year: 2013..Specific Aim 2 will explore TLR-dependent immunological mechanisms by which HSV-2, Neisseria gonorrhoeae, and Candida albicans modulate the efficacy of lead microbicides...
- Molecular Targets in Peptidoglycan SynthesisChristopher Davies; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae is the causative agent for the sexually transmitted disease gonorrhea and was responsible for over 350,000 infections in the U.S. in 2007...
- Co-factors in HIV Mucosal InfectionGregory A Viglianti; Fiscal Year: 2012..Our initial goal is to determine the role of Neisseria gonorrhoeae exposure or TLR-signaling in augmenting HIV-1 infection of target cells that are found in the ..
- Type IV secretion by Neisseria gonorrhoeaeJoseph P Dillard; Fiscal Year: 2012DESCRIPTION (provided by applicant): Neisseria gonorrhoeae is the causative agent of the sexually-transmitted disease gonorrhea as well as pelvic inflammatory disease, and disseminated gonococcal infection...
- Molecular analysis of oriT-independent transfer in the gonococcal R-plasmidsLUIS TORRES-BAUZA; Fiscal Year: 2012DESCRIPTION (provided by applicant): The emergence of strains of Neisseria gonorrhoeae that express clinically significant levels of resistance to penicillin and tetracycline is a global problem...
- Peptide Deformylase Inhibitor LBM415 for Sexually Transmitted InfectionsHuizhou Fan; Fiscal Year: 2011..Chlamydia trachomatis and Neisseria gonorrhoeae are the most common sexually transmitted pathogens...
- GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICEAnn E Jerse; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae (Gc) induces an intense inflammatory response that is characterized by the presence of numerous polymorphonuclear leukocytes (PMNs) with intracellular Gc...
- Interaction of Neisseria gonorrhoeae with polarized human endocervical epithelialWenxia Song; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae, an obligate human pathogen, causes a common sexually transmitted infection, gonorrhea...
- Complement and hormone receptor modulation during gonococcal cervical infectionJennifer L Edwards; Fiscal Year: 2010..Women are prone to develop chronic, often severe, consequences as a result of cervical infection with Neisseria gonorrhoeae. Although clinical data indicate that there is a hormonal component to gonococcal infection in women, this ..
- Structure and dynamics of bacterial membrane protein - receptor interactionsLINDA M COLUMBUS; Fiscal Year: 2013..Specifically, research is focused on the outer membrane opacity-associated proteins (Opa) from Neisseria gonorrhoeae and Neisseria meningitides, which induce engulfment of the bacterium in non-phagocytic cells by binding to ..
- Genetic Variation in genes involved in Neisseria gonorrhoeae LOS biosynthesisDaniel C Stein; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae is responsible for over 1 million cases of gonorrhea each year in the United States...
- Modulation of Virulence Determinants Contributing to Gonococcal PathogenesisDaniel Williams; Fiscal Year: 2010b>Neisseria gonorrhoeae is a Gram-negative, strict human pathogen that causes the sexually transmitted disease, gonorrhea...
- GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICEANN JERSE; Fiscal Year: 2009b>Neisseria gonorrhoeae (Gc) induces an intense inflammatory response that is characterized by the presence of numerous polymorphonuclear leukocytes (PMNs) with intracellular Gc. PMNs kill Gc in vitro, but not by oxygen-dependent defenses...
- LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeaePei Zhou; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae is the etiologic agent of the sexually transmitted infection, gonorrhea. Antibiotics are the mainstay in treating infections, but widespread resistance in N...
- A Multiplex Point-of-Care Test for Vaginal InfectionsMatthew Steele; Fiscal Year: 2010..NA) amplification lab-on-a-card diagnostic for the rapid identification of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and bacteria specific for bacterial vaginosis individually or simultaneously from ..
- Pathogenic Neisseria MeetingCaroline A Genco; Fiscal Year: 2010..IPNC 2010) is the premier international conference focused exclusively on Neisseria meningitidis and Neisseria gonorrhoeae. The IPNC has taken place every two years since the inaugural meeting in San Francisco in 1978...
- Cell separation in Neisseria gonorrhoeaeJoseph P Dillard; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae causes a very common sexually transmitted disease in men and women that often results in severe consequences for women including pelvic inflammatory disease, ectopic pregnancy, ..
- Gonococcal interactions with human polymorphonuclear leukocytesAlison K Criss; Fiscal Year: 2011b>Neisseria gonorrhoeae (Gc) is a human-specific bacterial pathogen that causes the sexually transmitted disease gonorrhea...
- Mechanisms of Gonococcal Pilin Antigenic and Phase VariationHank S Seifert; Fiscal Year: 2013..proposal will further our studies into the molecular mechanisms used to allow pilin antigenic variation in Neisseria gonorrhoeae. High frequency changes in the pilin amino acid sequence are mediated by gene conversion reactions between ..
- Survival of Neisseria gonorrhoeae after primary human neutrophil challengeAlison K Criss; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae (Gc) is an obligate human bacterial pathogen and the cause of the sexually transmitted infection gonorrhea...
- Genomic epidemiology of Neisseria gonorrhoeae with elevated MICs to cefiximeYonatan H Grad; Fiscal Year: 2013..by applicant): This proposal presents a five-year research career development program in the study of Neisseria gonorrhoeae biology and epidemiology. The candidate is training in Infectious Diseases...
- Peptidoglycan metabolism and fragment releaseJoseph P Dillard; Fiscal Year: 2013..In infections caused by Neisseria gonorrhoeae, Bordetella pertussis, or Shigella flexneri, peptidoglycan fragments are thought to induce a large ..
- Clinical Epidemiology of Mycoplasma genitaliumPatricia Totten; Fiscal Year: 2006..idiopathic, not attributable to the major sexually transmitted pathogens such as Chlamydia trachomatis or Neisseria gonorrhoeae. Where effective STD control programs exist, most urethritis in men and endocervicitis or mucopurulent ..
- Mechanisms of antibiotic action in Neisseria gonorrhoeae.Robert A Nicholas; Fiscal Year: 2010..Together, these projects utilize genetic, biochemical, biophysical, and proteomics approaches to generate new insights into the mechanisms of antibiotic action in N. gonorrhoeae. ..
- Role of bacteriophage in Neisseria gonorrhoeae biologyDaniel C Stein; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae contains 9 genetic islands that encode for bacteriophage. The role that these bacteriophage play in gonococcal biology is unknown...
- Southeastern Sexually Transmitted Infections Cooperative Research CenterPhilip Frederick Sparling; Fiscal Year: 2013..Southeastern STI ORG is comprised of six projects Including studies on the sexually transmitted pathogens Neisseria gonorrhoeae and Haemophilus ducreyi...
- Developmental Epidemiology of Incident STI among Adolescent BoysMary A Ott; Fiscal Year: 2010..is to examine, longitudinally, incident infections with three common bacterial STI (Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis) among young men from middle to late adolescence...
- Role of C7 in Resistance to Neisseria InfectionsMichael C Braun; Fiscal Year: 2011..with deficiencies of C6, C7, and C8, but not C9 are at a uniquely higher risk for infection with Neisseria gonorrhoeae and Neisseria meningitidis...
- Innate and Adaptive Immunity in Experimental and Human Gonoccocal InfectionPeter A Rice; Fiscal Year: 2013..We will emphasize basic host responses and innate immune mechanisms in infection with Neisseria gonorrhoeae with the immediate aim of improving understanding of gonococcal immunology and pathogenesis and a longer ..
- IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAEPeter A Rice; Fiscal Year: 2013b>Neisseria gonorrhoeae is one of the two major pathogens involved in the majority of cases of sexually transmitted genital infection. Complement forms an important aspect of the innate immune system that impacts upon gonococcal infection...
- Anti-HIV-1 Composite Cellulose Acetate Phthalate FilmShibo Jiang; Fiscal Year: 2006..CAP also a) inactivates herpesviruses HSV-1, HSV-2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, Chlamydia trachomatis, Treponema pallidum and bacteria ..
- The affect of hormones and oxygen-limitation on gonococcal pathophysiologyJennifer L Edwards; Fiscal Year: 2012..Women are more prone to develop chronic, often severe, consequences as a result of cervical infection with Neisseria gonorrhoeae, the bacterium that causes gonorrhea...
- Therapy and Prophylaxis for Genital Tract InfectionYingru Liu; Fiscal Year: 2013DESCRIPTION (provided by applicant): Genital tract infection with Neisseria gonorrhoeae (gonorrhea) does not induce a state of specific protective immunity and can be acquired repeatedly...
- Neisseria gonorrhoeae G4-binding proteins that regulate pilin antigenic variationELLA ROSE ROTMAN; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: By changing their surface pili, the pathogenic bacterium Neisseria gonorrhoeae can infect previously cured hosts...
- Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)A Robert Neurath; Fiscal Year: 2004..HSV-2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi and Chlamydia trachomatis; b) inactivated bacteria associated ..
- Role of Neisseria Gcp in Tfp dynamics and invasionMAGDALENE Y SO; Fiscal Year: 2012b>Neisseria gonorrhoeae is a human pathogen that can persists on the mucosa for lengthy periods without causing overt symptoms of disease...
- Polyamine Modulation of Goncoccal VirulenceWILLIAM MAURICE SHAFER; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae is a strict human pathogen that causes an estimated ninety-five million cases of gonorrhea worldwide each year...
- The Gonococcal Fur Regulon: Link to PathogenesisCaroline A Genco; Fiscal Year: 2012..In the previously funded RO1 we conducted studies to test the hypothesis that in Neisseria gonorrhoeae and N...
- IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAEPeter Rice; Fiscal Year: 2003DESCRIPTION: (Adapted from the application abstract) Neisseria gonorrhoeae is one of the two major pathogens involved in the majority of cases of bacterial sexually transmitted genital infection and pelvic inflammatory disease (PID)...
- Innate Immune Receptors in Host Responses to NeisseriaROBIN INGALLS; Fiscal Year: 2009DESCRIPTION (provided by applicant): The human pathogen Neisseria gonorrhoeae produces an array of diseases ranging from urethritis and cervicitis to pelvic inflammatory disease...
- GONOCOCCAL PIA--ROLE IN INVASION OF FALLOPIAN TUBE CELLGARY GORBY; Fiscal Year: 1999b>Neisseria gonorrhoeae (GC) is able to attach to and invade non-ciliated epithelial cells of the Fallopian tube organ culture model (FTOC). The mechanism of this interaction remains to be defined...
- Molecular Genetics of the gonococcusHank S Seifert; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neisseria gonorrhoeae (Gc) is a sexually transmitted infectious agent that is the only causative agent of the disease gonorrhea...
- CR3 IN CELL ACTIVATION AND PHAGOCYTOSIS OF GONORRHEAROBIN INGALLS; Fiscal Year: 2001b>Neisseria gonorrhoeae (GC) is one of the most common sexually transmitted pathogens in the United States, Infection with GC usually remains localized to the lower genital tract, although certain strains are capable of dissemination...
- CRYSTALLOGRAPHIC STUDIES OF NEISSERIA FE BINDING PROTEINDuncan McRee; Fiscal Year: 1999..b>Neisseria gonorrhoeae and Neisseria meningitidis are closely related pathogens which remain wide-spread health problems...
- Urinary Symptoms in Adolescent Females: STI or UTI?Jill Huppert; Fiscal Year: 2004..age group at highest risk for STIs, the CDC recommends annual screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in all sexually active (SA) adolescents, regardless of symptoms...
- REDUCTION OF MOLECULAR OXYGEN BY NEISSERIA GONORRHOEAEERMINIA NORROD; Fiscal Year: 1991..Very little is known about the interactions of the aerobic Neisseria gonorrhoeae with reduced forms of oxygen, either from endogenous or exogenous sources...
- INTRACELLULAR FATE OF NEISSERIA GONORRHOEAERichard Rest; Fiscal Year: 2000DESCRIPTION (Adapted from the applicant's abstract): Neisseria gonorrhoeae (the gonococcus) is the etiologic agent of gonorrhea...
- Rapid Point-of-Care Diagnostic Test for Chlamydia and GonorrheaDAVID DOLINGER; Fiscal Year: 2007..POC), nucleic acid amplification based diagnostic test for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae using our innovative "Lab-in-a-tube" (LiatTM) technology...
- Transcytosis of Neisseria gonorrhoeae through T84 epithelial cellsLUZ ANGELA LE VAN; Fiscal Year: 2009DESCRIPTION (provided by applicant): Neisseria gonorrhoeae is the causative agent of gonorrhea;humans are their only natural host. Neisseria can disseminate from the mucosal surface to cause severe diseases...
- Mechanisms of Host Responses in GonorrheaTie Chen; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): Neisseria gonorrhoeae (gonococci, GC) cause gonorrhea and pelvic inflammatory disease (PID)...
- IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDEJOHN GRIFFISS; Fiscal Year: 2003..of how lipooligosaccharide (LOS) mimicry of human glycosphingolipids (GSL) enables the transmission of Neisseria gonorrhoeae in order to find ways to prevent it...
- VACCINE POTENTIAL OF GONOCOCCAL OMP85RALPH JUDD; Fiscal Year: 2001DESCRIPTION: (Adapted from the Applicant's Abstract) Neisseria gonorrhoeae infects up to half a million people yearly in the US, causing a variety of diseases. Treatment of these diseases costs billions of dollars each year...
- ROLE OF PEPTIDOGLYCAN IN HEALTH AND DISEASERAOUL ROSENTHAL; Fiscal Year: 1993..The first system is based on our previous suggestion that PG derived for Neisseria gonorrhoeae contributes to the acute inflammatory reactions, e.g...
- FUNCTION OF GONOCOCCAL ANAEROBICALLY INDUCED PROTEINSVirginia Clark; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Neisseria gonorrhoeae is the etiologic agent of gonorrhea, one of the most prevalent infectious diseases in the U.S...
- CELLULAR TRAFFICKING TO INFLAMED FEMALE GENITAL MUCOSAKathleen Kelly; Fiscal Year: 2001..and ectopic pregnancy typically emerge in females after a chronic infection with Chlamydia trachomatis or Neisseria gonorrhoeae. Due to the insidious nature of chlamydial infections, efforts have been put forth to develop a vaccine ..