klebsiella pneumoniae

Summary

Summary: Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.

Top Publications

  1. pmc Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India
    Dongeun Yong
    Yonsei University College of Medicine, Research Institute of Antimicrobial Resistance, Seoul, Republic of Korea
    Antimicrob Agents Chemother 53:5046-54. 2009
  2. ncbi The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    Patrice Nordmann
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, K Bicêtre, France
    Lancet Infect Dis 9:228-36. 2009
  3. pmc MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression
    Jonathan J Wilksch
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    PLoS Pathog 7:e1002204. 2011
  4. ncbi ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China
    Yan Qi
    Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    J Antimicrob Chemother 66:307-12. 2011
  5. ncbi Structural changes induced by a lytic bacteriophage make ciprofloxacin effective against older biofilm of Klebsiella pneumoniae
    Vivek Verma
    Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, Chandigarh, India
    Biofouling 26:729-37. 2010
  6. ncbi An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009-10)
    Panagiota Giakkoupi
    Department of Microbiology, National School of Public Health, Athens, Greece
    J Antimicrob Chemother 66:1510-3. 2011
  7. ncbi Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies
    Gopi Patel
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Infect Control Hosp Epidemiol 29:1099-106. 2008
  8. pmc Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae
    H Yigit
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 45:1151-61. 2001
  9. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
  10. pmc oxyR, a LysR-type regulator involved in Klebsiella pneumoniae mucosal and abiotic colonization
    Claire Hennequin
    Université de Clermont 1, UFR Pharmacie, Laboratoire de Bacteriologie, 28 Place Henri Dunant, Clermont Ferrand F 63001, France
    Infect Immun 77:5449-57. 2009

Detail Information

Publications330 found, 100 shown here

  1. pmc Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India
    Dongeun Yong
    Yonsei University College of Medicine, Research Institute of Antimicrobial Resistance, Seoul, Republic of Korea
    Antimicrob Agents Chemother 53:5046-54. 2009
    ..traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex...
  2. ncbi The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    Patrice Nordmann
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, K Bicêtre, France
    Lancet Infect Dis 9:228-36. 2009
    From early this decade, Enterobacteriaceae that produce Klebsiella pneumoniae carbapenemases (KPC) were reported in the USA and subsequently worldwide...
  3. pmc MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression
    Jonathan J Wilksch
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    PLoS Pathog 7:e1002204. 2011
    b>Klebsiella pneumoniae causes significant morbidity and mortality worldwide, particularly amongst hospitalized individuals...
  4. ncbi ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China
    Yan Qi
    Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    J Antimicrob Chemother 66:307-12. 2011
    b>Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae has spread rapidly in China. In this study, we aimed to investigate the molecular epidemiology of KPC-producing K. pneumoniae isolates in China.
  5. ncbi Structural changes induced by a lytic bacteriophage make ciprofloxacin effective against older biofilm of Klebsiella pneumoniae
    Vivek Verma
    Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, Chandigarh, India
    Biofouling 26:729-37. 2010
    ..It has been documented that young biofilm of Klebsiella pneumoniae could be eradicated significantly by ciprofloxacin treatment alone...
  6. ncbi An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009-10)
    Panagiota Giakkoupi
    Department of Microbiology, National School of Public Health, Athens, Greece
    J Antimicrob Chemother 66:1510-3. 2011
    To follow the epidemic of KPC-2-producing Klebsiella pneumoniae in Greece.
  7. ncbi Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies
    Gopi Patel
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Infect Control Hosp Epidemiol 29:1099-106. 2008
    Carbapenem-resistant Klebsiella pneumoniae is an emerging healthcare-associated pathogen.
  8. pmc Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae
    H Yigit
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 45:1151-61. 2001
    A Klebsiella pneumoniae isolate showing moderate to high-level imipenem and meropenem resistance was investigated. The MICs of both drugs were 16 microg/ml...
  9. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
    ..the past two decades in Taiwan, pyogenic liver abscess has usually been caused by a single microorganism, Klebsiella pneumoniae, and is frequently associated with the serious complication of endophthalmitis, especially in diabetic ..
  10. pmc oxyR, a LysR-type regulator involved in Klebsiella pneumoniae mucosal and abiotic colonization
    Claire Hennequin
    Université de Clermont 1, UFR Pharmacie, Laboratoire de Bacteriologie, 28 Place Henri Dunant, Clermont Ferrand F 63001, France
    Infect Immun 77:5449-57. 2009
    Colonization of the gastrointestinal tract is the first event in Klebsiella pneumoniae nosocomial infections, followed by colonization of the bladder or respiratory tract or entry into the bloodstream...
  11. pmc Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil
    Leonardo Neves Andrade
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Antimicrob Agents Chemother 55:3579-83. 2011
    ..It also constitutes the first description of sequence type 258 (ST258) in Brazil, which was associated with a nosocomial hospital outbreak in Ribeirao Preto city...
  12. ncbi Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns
    Khetam Hussein
    Infectious Diseases Unit, Rambam Medical Center, Haifa, Israel
    Infect Control Hosp Epidemiol 30:666-71. 2009
    Carbapenem resistance among isolates of Klebsiella pneumoniae has been unusual.
  13. ncbi An outbreak of infection due to beta-Lactamase Klebsiella pneumoniae Carbapenemase 2-producing K. pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomes
    Maria Souli
    4th Dept of Internal Medicine, University General Hospital Attikon, 1 Rimini Str 124 62, Chaidari, Greece
    Clin Infect Dis 50:364-73. 2010
    We describe the emergence and spread of Klebsiella pneumoniae carbapenemase 2 (KPC-2)-producing K. pneumoniae at a Greek University hospital.
  14. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
    ..To test this, we used a model of Klebsiella pneumoniae lung infection in mice genetically deficient in IL-17R or in mice overexpressing a soluble IL-17R...
  15. pmc Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates
    Laure Diancourt
    Unité Biodiversité des Bactéries Pathogènes Emergentes U389 INSERM, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
    J Clin Microbiol 43:4178-82. 2005
    A multilocus sequence typing (MLST) scheme was developed for Klebsiella pneumoniae. Sequences of seven housekeeping genes were obtained for 67 K. pneumoniae strains, including 19 ceftazidime- and ciprofloxacin-resistant isolates...
  16. ncbi Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess
    Chi Tai Fang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 45:284-93. 2007
    Since 1986, researchers have noted a syndrome of Klebsiella pneumoniae pyogenic liver abscess that is complicated by endophthalmitis or central nervous system infections...
  17. ncbi Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea
    D R Chung
    Division of Infectious Diseases, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi do 431 070, South Korea
    J Infect 54:578-83. 2007
    The high incidence of invasive liver abscess caused by Klebsiella pneumoniae in Taiwan, contrasted with the rareness of this disease in Western countries, has aroused special interest...
  18. pmc Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis
    Keh Ming Wu
    Institute of Genome Sciences, National Yang Ming University, Taipei, Taiwan
    J Bacteriol 191:4492-501. 2009
    Nosocomial infections caused by antibiotic-resistant Klebsiella pneumoniae are emerging as a major health problem worldwide, while community-acquired K...
  19. pmc Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model
    Suzanne Bialek
    Service de Microbiologie, Hôpital AP HP Beaujon, Clichy, France
    Antimicrob Agents Chemother 54:4373-8. 2010
    ..nalidixic acid [NAL]) related to a putative efflux system overexpression has recently been reported for Klebsiella pneumoniae. The potential impact of this multidrug resistance (MDR) on the virulence of K...
  20. ncbi Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case control study
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 60:1124-30. 2007
    Carbapenems are frequently used to treat infections due to extended-spectrum beta-lactamase-producing Klebsiella pneumoniae. Thus, the emergence of infections due to carbapenem-resistant K...
  21. ncbi Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes
    E Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Clin Infect Dis 32:1162-71. 2001
    ..of antibiotic resistance among extended-spectrum beta-lactamase (ESBL)--producing Escherichia coli and Klebsiella pneumoniae has increased markedly in recent years. Thirty-three patients with infection due to ESBL-producing E...
  22. pmc Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns
    Wen Chien Ko
    National Cheng Kung University Medical College, Taiwan
    Emerg Infect Dis 8:160-6. 2002
    ..worldwide collaborative study, including 455 episodes of bacteremia, to elucidate the clinical patterns of Klebsiella pneumoniae. Historically, community-acquired pneumonia has been consistently associated with K. pneumoniae...
  23. pmc Carbapenemases: the versatile beta-lactamases
    Anne Marie Queenan
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Clin Microbiol Rev 20:440-58, table of contents. 2007
    ..Of these, the KPC carbapenemases are the most prevalent, found mostly on plasmids in Klebsiella pneumoniae. The class D carbapenemases consist of OXA-type beta-lactamases frequently detected in Acinetobacter ..
  24. pmc Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival
    E Broug-Holub
    Department of Cell Biology and Immunology, Vrije Universiteit, Amsterdam, The Netherlands
    Infect Immun 65:1139-46. 1997
    ..Subsequently, the AM-depleted mice were infected i.t. with 100 CFU of Klebsiella pneumoniae, and the effects of AM depletion on survival, bacterial clearance, and neutrophil (polymorphonuclear ..
  25. ncbi Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase
    Thomas R M Barends
    Max Planck Institute for Medical Research, Department of Biomolecular Mechanisms, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nature 459:1015-8. 2009
    ..mechanistic characterization of a full-length, active photoreceptor, BlrP1 (also known as KPN_01598), from Klebsiella pneumoniae. BlrP1 consists of a BLUF sensor domain and a phosphodiesterase EAL output domain which hydrolyses cyclic ..
  26. ncbi Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium
    Simona Bratu
    Division of Infectious Diseases, State University of New York Downstate, Brooklyn, NY 11203, USA
    Arch Intern Med 165:1430-5. 2005
    ..Carbapenem resistance has been unusual in isolates of Klebsiella pneumoniae. In this study, the prevalence and molecular epidemiologic characteristics of carbapenem-resistant K ..
  27. pmc Capsular polysaccharide synthesis regions in Klebsiella pneumoniae serotype K57 and a new capsular serotype
    Yi Jiun Pan
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Clin Microbiol 46:2231-40. 2008
    Community-acquired pyogenic liver abscess caused by Klebsiella pneumoniae is an emerging infectious disease. We explored the capsular polysaccharide synthesis (cps) regions of three non-K1, non-K2 K...
  28. ncbi Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection
    Ren Wen Tsay
    Division of Infectious Diseases and Tropical Medicine, Tri Service General Hospital, No 325, Section 2, Cheng Kung Road, Neihu, 114 Taipei, Taiwan
    Arch Intern Med 162:1021-7. 2002
    ..Although several epidemiological surveys of Klebsiella clinical isolates have been performed, few studies have correlated the clinical isolate with disease...
  29. ncbi Characterization of a T7-like lytic bacteriophage of Klebsiella pneumoniae B5055: a potential therapeutic agent
    Vivek Verma
    Department of Microbiology, Panjab University, Chandigarh, 160014, India
    Curr Microbiol 59:274-81. 2009
    ..In the present study, one lytic bacteriophage, KPO1K2, specific for Klebsiella pneumoniae B5055, with broad host range was selected for characterization...
  30. ncbi CTX-M-15-producing Escherichia coli clinical isolates in Cairo (Egypt), including isolates of clonal complex ST10 and clones ST131, ST73, and ST405 in both community and hospital settings
    Nevine Fam
    Microbiology Department, Theodor Bilharz Research Institute, Cairo, Egypt
    Microb Drug Resist 17:67-73. 2011
    ..Among the collected Enterobacteriaceae, 56% (n=291) were E. coli and 32% (n=165) Klebsiella pneumoniae. A total of 16% (n=3) of all isolates were ESBL, 19% (n=55) of the E. coli and 14% (n=23) of the K...
  31. ncbi High prevalence of CTX-M-15-producing Klebsiella pneumoniae isolates in Asian countries: diverse clones and clonal dissemination
    Mi Young Lee
    Asia Pacific Foundation for Infectious Diseases, Seoul, South Korea
    Int J Antimicrob Agents 38:160-3. 2011
    The characteristics of 218 Klebsiella pneumoniae isolates from patients with hospital-acquired pneumonia in nine Asian countries were investigated. In total, 92 isolates (42...
  32. pmc Sequencing and genetic variation of multidrug resistance plasmids in Klebsiella pneumoniae
    Fangqing Zhao
    Institute of Biomedical Informatics, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, China
    PLoS ONE 5:e10141. 2010
    ..Characterizing the genetic variation among plasmids from different bacterial species or strains is a key step towards understanding the mechanism of virulence and their evolution...
  33. pmc Risk factors and outcomes associated with acquisition of colistin-resistant KPC-producing Klebsiella pneumoniae: a matched case-control study
    Olympia Zarkotou
    Department of Microbiology, Tzaneio General Hospital, Piraeus, Greece
    J Clin Microbiol 48:2271-4. 2010
    ..study investigated factors predicting colistin-resistant versus colistin-susceptible KPC-producing Klebsiella pneumoniae acquisition and its impact on patient outcomes...
  34. ncbi Comparison of CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae isolates from patients with bacteremia
    Juyoun Shin
    Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Jangan ku, Suwon 440 746, South Korea
    J Infect 63:39-47. 2011
    ..of CTX-M-15-type extended-spectrum β-lactamase, we compared the CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae isolates with CTX-M-14-producing E. coli and K...
  35. pmc Isolation of genes involved in biofilm formation of a Klebsiella pneumoniae strain causing pyogenic liver abscess
    Meng Chuan Wu
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    PLoS ONE 6:e23500. 2011
    Community-acquired pyogenic liver abscess (PLA) complicated with meningitis and endophthalmitis caused by Klebsiella pneumoniae is an emerging infectious disease. To investigate the mechanisms and effects of biofilm formation of K...
  36. pmc Comparative structure-function analysis of mannose-specific FimH adhesins from Klebsiella pneumoniae and Escherichia coli
    Steen G Stahlhut
    Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, 2300 Copenhagen S, Denmark
    J Bacteriol 191:6592-601. 2009
    ..In this study, we compared functional properties of the FimH proteins from Escherichia coli and Klebsiella pneumoniae, which are both 279 amino acids in length but differ by some approximately 15% of residues. We show that K...
  37. pmc Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan
    L Kristopher Siu
    Division of Infectious Diseases, National Health Research Institutes, Taichung, Taiwan
    J Clin Microbiol 49:3761-5. 2011
    Serotype K1 Klebsiella pneumoniae with multilocus sequence type 23 (ST23) has been strongly associated with liver abscess in Taiwan...
  38. ncbi Clinical and phenotypic differences between classic and hypervirulent Klebsiella pneumonia: an emerging and under-recognized pathogenic variant
    D K Pomakova
    Veterans Administration Western New York Healthcare System, Buffalo, NY, USA
    Eur J Clin Microbiol Infect Dis 31:981-9. 2012
    ..This will improve our understanding of the epidemiology and clinical spectrum of infection, which may be more extensive than appreciated...
  39. ncbi Risk factors for endogenous endophthalmitis secondary to klebsiella pneumoniae liver abscess: 20-year experience in Southern Taiwan
    Shwu Jiuan Sheu
    Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan
    Retina 31:2026-31. 2011
    To identify the risk factors for endogenous endophthalmitis secondary to Klebsiella pneumoniae liver abscess.
  40. ncbi Fur-dependent MrkHI regulation of type 3 fimbriae in Klebsiella pneumoniae CG43
    Chien Chen Wu
    Department of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Taiwan, ROC
    Microbiology 158:1045-56. 2012
    Type 3 fimbriae play a crucial role in Klebsiella pneumoniae biofilm formation, but the mechanism of the regulation of the type 3 fimbrial operon is largely unknown. In K...
  41. ncbi Fur regulation of the capsular polysaccharide biosynthesis and iron-acquisition systems in Klebsiella pneumoniae CG43
    Ching Ting Lin
    School of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan, ROC
    Microbiology 157:419-29. 2011
    ..gene for the mucoid phenotype, leading to decreased capsular polysaccharide (CPS) biosynthesis in Klebsiella pneumoniae CG43...
  42. ncbi Homologous response regulators KvgA, KvhA and KvhR regulate the synthesis of capsular polysaccharide in Klebsiella pneumoniae CG43 in a coordinated manner
    Ching Ting Lin
    Department of Biological Science and Technology, National Chiao Tung University, 75 Po Ai Street, Hsin Chu 30050, Taiwan, Republic of China
    J Biochem 140:429-38. 2006
    On the basis of phenotypic analysis, the Klebsiella pneumoniae CG43 derived mutants with deletions of the gene encoding respectively the response regulators KvgA, KvhA, and KvhR were classified into two groups...
  43. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
    Twenty-one Serratia marcescens, ten Klebsiella pneumoniae, and one Escherichia coli isolate with carbapenem resistance or reduced carbapenem susceptibility were recovered from intensive care units (ICUs) in our hospital...
  44. pmc New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada
    Michael R Mulvey
    Antimicrobial Resistance and Nosocomial Infections section, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Emerg Infect Dis 17:103-6. 2011
    Multidrug-resistant Klebsiella pneumoniae and Escherichia coli isolates harboring New Delhi metallo-β-lactamase (NDM-1) were isolated from a patient who had returned to Canada from India...
  45. ncbi Enhanced 2,3-butanediol production by Klebsiella pneumoniae SDM
    Cuiqing Ma
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 82:49-57. 2009
    Enhanced 2,3-butanediol (BD) production was carried out by Klebsiella pneumoniae SDM. The nutritional requirements for BD production by K. pneumoniae SDM were optimized statistically in shake flask fermentations...
  46. ncbi Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae
    R Dutzler
    Department of Structural Biology, Biozentrum University of Basel, CH 4056 Basel, Switzerland
    Structure 7:425-34. 1999
    ..Here, we study osmoporin of the pathogenic Klebsiella pneumoniae (OmpK36), which shares 87% sequence identity with E...
  47. ncbi Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice
    Sanjay Chhibber
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Med Microbiol 57:1508-13. 2008
    b>Klebsiella pneumoniae causes infections in humans especially in immunocompromised patients. About 80 % of nosocomial infections caused by K. pneumoniae are due to multidrug-resistant strains...
  48. ncbi Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece)
    H C Maltezou
    Department for Interventions in Health Care Facilities, Hellenic Centre for Disease Control and Prevention, Athens, Greece
    J Infect 58:213-9. 2009
    Starting in May 2007, an ongoing outbreak of infections due to carbapenem resistant KPC-2-producing Klebsiella pneumoniae occurred in a tertiary care hospital in Crete (Greece)...
  49. ncbi Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Clin Infect Dis 52:848-55. 2011
    During 2006, Israeli hospitals faced a clonal outbreak of carbapenem-resistant Klebsiella pneumoniae that was not controlled by local measures...
  50. ncbi Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection
    Elizabeth B Hirsch
    University of Houston College of Pharmacy, and St Luke s Episcopal Hospital, Houston, TX, USA
    J Antimicrob Chemother 65:1119-25. 2010
    Bacteria producing Klebsiella pneumoniae carbapenemases (KPCs) are rapidly emerging as a cause of multidrug-resistant infections worldwide...
  51. pmc Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
    Chi Hye Park
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 50:3953-5. 2006
    ..aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes...
  52. pmc Pyogenic liver abscess as endemic disease, Taiwan
    Feng Chiao Tsai
    National Taiwan University Hospital, Taipei, Taiwan
    Emerg Infect Dis 14:1592-600. 2008
    ..Renal disease, malignancy, pneumonia, and heart disease correlated with higher death rates; Klebsiella pneumoniae infection and therapeutic procedures were related to lower death rates...
  53. pmc Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae
    Laurent Poirel
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:15-22. 2004
    b>Klebsiella pneumoniae strain 11978 was isolated in Turkey in 2001 and was found to be resistant to all beta-lactams, including carbapenems...
  54. pmc Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258
    Brandon Kitchel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 53:3365-70. 2009
    b>Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have become more common in the United States and throughout the world...
  55. pmc A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications
    Chi Tai Fang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei 100
    J Exp Med 199:697-705. 2004
    Primary Klebsiella pneumoniae liver abscess complicated with metastatic meningitis or endophthalmitis is a globally emerging infectious disease. Its pathogenic mechanism remains unclear...
  56. pmc Capsular serotype K1 or K2, rather than magA and rmpA, is a major virulence determinant for Klebsiella pneumoniae liver abscess in Singapore and Taiwan
    Kuo Ming Yeh
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    J Clin Microbiol 45:466-71. 2007
    Capsular serotypes, magA, and rmpA have been documented in high prevalence for Klebsiella pneumoniae liver abscess...
  57. pmc Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA
    Andrea Endimiani
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Research Service, Cleveland, OH 44106, USA
    J Antimicrob Chemother 63:427-37. 2009
    The emergence of bla(KPC)-containing Klebsiella pneumoniae (KPC-Kp) isolates is attracting significant attention. Outbreaks in the Eastern USA have created serious treatment and infection control problems...
  58. ncbi Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia
    Abraham Borer
    Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Infect Control Hosp Epidemiol 30:972-6. 2009
    To determine the attributable (direct) mortality and morbidity caused by carbapenem-resistant Klebsiella pneumoniae bacteremia.
  59. pmc Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China
    Ze Qing Wei
    Key Laboratory of Infectious Diseases of the Public Health Ministry, 1st Affiliated Hospital, Medical School, Zhejiang University, Hangzhou, Zhejiang, China
    Antimicrob Agents Chemother 51:763-5. 2007
    A carbapenem-resistant isolate of Klebsiella pneumoniae producing class A carbapenemase KPC-2 was identified in Zhejiang, China...
  60. pmc High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe
    Frank M Kaczmarek
    Pfizer Global Research and Development, Groton, CT 06340, USA
    Antimicrob Agents Chemother 50:3396-406. 2006
    Clinical isolates of Klebsiella pneumoniae resistant to carbapenems and essentially all other antibiotics (multidrug resistant) are being isolated from some hospitals in New York City with increasing frequency. A highly related pair of K...
  61. ncbi Cloverleaf test (modified Hodge test) for detecting carbapenemase production in Klebsiella pneumoniae: be aware of false positive results
    Cecilia G Carvalhaes
    Laboratório ALERTA, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    J Antimicrob Chemother 65:249-51. 2010
    The aim of this study was to evaluate the presence of carbapenemases in a Klebsiella pneumoniae collection and the performance of the modified Hodge test (MHT) to correctly identify this phenotype.
  62. pmc Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene
    Thierry Naas
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicêtre 94275, and Faculté de Médecine Paris Sud, Paris, France
    Antimicrob Agents Chemother 52:1257-63. 2008
    ..the carbapenem-hydrolyzing Ambler class A bla KPC gene were characterized in several KPC-positive Klebsiella pneumoniae and Pseudomonas aeruginosa strains isolated from the United States, Colombia, and Greece...
  63. pmc Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection
    Shanshan Cai
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    J Immunol 183:6629-38. 2009
    b>Klebsiella pneumoniae causes extensive lung damage. TLR signaling involves adaptors TRIF and MyD88. However, the relative contribution of TRIF and MyD88 signaling in host defense against pulmonary K...
  64. ncbi Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model
    Matthew S Lawlor
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Microbiol 58:1054-73. 2005
    b>Klebsiella pneumoniae is a Gram-negative enterobacterium that has historically been, and currently remains, a significant cause of human disease...
  65. ncbi NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, Paris, France
    J Antimicrob Chemother 66:304-6. 2011
    To analyse the mechanisms responsible for multidrug resistance in two carbapenem-resistant Klebsiella pneumoniae isolates recovered from patients hospitalized in Oman.
  66. ncbi Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan
    Wen Liang Yu
    Department of Intensive Care Medicine, Chi Mei Medical Center, Yungkang City, Tainan, Taiwan
    Clin Infect Dis 42:1351-8. 2006
    The association of the magA gene with the hypermucoviscosity phenotype relevant to the pathogenesis of Klebsiella pneumoniae liver abscess has been reported in Taiwan...
  67. ncbi magA is not a specific virulence gene for Klebsiella pneumoniae strains causing liver abscess but is part of the capsular polysaccharide gene cluster of K. pneumoniae serotype K1
    Kuo Ming Yeh
    J Med Microbiol 55:803-4. 2006
  68. ncbi The clinical consequences of antimicrobial resistance
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Curr Opin Microbiol 12:476-81. 2009
    ..the carbapenems, is compromised by the growth, primarily in intensive care units, of multiresistant Klebsiella pneumoniae, Acinetobacter baumanni, and Pseudomonas aeruginosa...
  69. ncbi Regulation of enteric endophytic bacterial colonization by plant defenses
    A Leonardo Iniguez
    University of Wisconsin Madison, Department of Agronomy, Madison 53706, USA
    Mol Plant Microbe Interact 18:169-78. 2005
    ..Some endophytes, such as Klebsiella pneumoniae 342 (Kp342), enhance plant growth and nutrition...
  70. pmc Complete nucleotide sequence of Klebsiella pneumoniae multidrug resistance plasmid pKP048, carrying blaKPC-2, blaDHA-1, qnrB4, and armA
    Yan Jiang
    Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China
    Antimicrob Agents Chemother 54:3967-9. 2010
    The Klebsiella pneumoniae multidrug resistance plasmid pKP048 was completely sequenced...
  71. pmc Capsule polysaccharide mediates bacterial resistance to antimicrobial peptides
    Miguel A Campos
    Unidad de Investigacion, Hospital Son Dureta, Andrea Doria 55, 07014 Palma Mallorca, Spain
    Infect Immun 72:7107-14. 2004
    ..b>Klebsiella pneumoniae CPS mutant was more sensitive than the wild type to human neutrophil defensin 1, beta-defensin 1, ..
  72. pmc Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 48:4793-9. 2004
    ..Y., were infected or colonized by carbapenem-resistant Klebsiella pneumoniae. Pulsed-field gel electrophoresis identified a predominant outbreak strain, but other resistant strains ..
  73. ncbi Isolation and characterization of Klebsiella pneumoniae specific bacteriophages from sewage samples
    S Kumari
    Department of Microbiology, Panjab University, Basic Medical Sciences Building, Chandigarh, 160014, India
    Folia Microbiol (Praha) 55:221-7. 2010
    Five bacteriophages (Kpn5, Kpn12, Kpn13, Kpn17 and Kpn22), each having specificity against Klebsiella pneumoniae strain B5055, were isolated from sewage samples and characterized in terms of growth characteristics, genetic material, ..
  74. pmc Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization
    Sylvain Brisse
    Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France
    PLoS ONE 4:e4982. 2009
    b>Klebsiella pneumoniae is found in the environment and as a harmless commensal, but is also a frequent nosocomial pathogen (causing urinary, respiratory and blood infections) and the agent of specific human infections including Friedlä..
  75. ncbi Clinical spectrum and molecular characteristics of Klebsiella pneumoniae causing community-acquired extrahepatic abscess
    Yee Huang Ku
    Division of Infectious Disease, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Taiwan
    J Microbiol Immunol Infect 41:311-7. 2008
    b>Klebsiella pneumoniae causes a wide spectrum of infections, including abscess and non-abscess formation...
  76. pmc Increase of ceftazidime- and fluoroquinolone-resistant Klebsiella pneumoniae and imipenem-resistant Acinetobacter spp. in Korea: analysis of KONSAR study data from 2005 and 2007
    Kyungwon Lee
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seodaemun gu, Seoul, Korea
    Yonsei Med J 51:901-11. 2010
    ..We analyzed antimicrobial resistance data generated by Korean Hospitals and by a commercial laboratory in 2005 and 2007...
  77. ncbi Endogenous Klebsiella endophthalmitis associated with pyogenic liver abscess
    Chang Sue Yang
    Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    Ophthalmology 114:876-80. 2007
    To study risk factors, clinical features, treatment, and visual outcomes in patients with endogenous Klebsiella pneumoniae endophthalmitis (EKE) associated with K...
  78. pmc Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece
    Gaelle Cuzon
    Antimicrob Agents Chemother 52:796-7. 2008
  79. pmc Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates
    Jean Marie Pages
    UMR MD 1, Facultes de Medecine et de Pharmacie, Universite de la Mediterranee, IFR88, Marseille, France
    PLoS ONE 4:e4817. 2009
    ..production and porin decrease are the well-recognized mechanisms of acquired beta-lactam resistance in Klebsiella pneumoniae isolates. However, such mechanisms proved to be absent in K...
  80. pmc In vivo efficacy of simulated human dosing regimens of prolonged-infusion doripenem against carbapenemase- producing Klebsiella pneumoniae
    Catharine C Bulik
    Center for Anti Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102, USA
    Antimicrob Agents Chemother 54:4112-5. 2010
    Carbapenemase-producing Klebsiella pneumoniae (KPC) bacteria are rapidly becoming one of the most detrimental drug-resistant Gram-negative pathogens...
  81. pmc Genetic requirements for Klebsiella pneumoniae-induced liver abscess in an oral infection model
    Ya Chun Tu
    Department of Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan, Republic of China
    Infect Immun 77:2657-71. 2009
    b>Klebsiella pneumoniae is the predominant pathogen of primary liver abscess. However, our knowledge regarding the molecular basis of how K. pneumoniae causes primary infection in the liver is limited...
  82. pmc Molecular characterisation of trimethoprim resistance in Escherichia coli and Klebsiella pneumoniae during a two year intervention on trimethoprim use
    Alma Brolund
    Department of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e9233. 2010
    ..We investigated the distribution of dihydrofolate reductase (dfr)-genes and integrons in Escherichia coli and Klebsiella pneumoniae and the effect of the intervention on this distribution.
  83. pmc ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline
    M Hentschke
    Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
    Antimicrob Agents Chemother 54:2720-3. 2010
    Five Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline (MIC, 2 microg/ml) were analyzed. A gene homologous to ramR of Salmonella enterica was identified in Klebsiella pneumoniae...
  84. pmc Real-time PCR and statistical analyses of acrAB and ramA expression in clinical isolates of Klebsiella pneumoniae
    Alexey Ruzin
    Department of Infectious Disease, Wyeth Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 52:3430-2. 2008
    Clinical isolates of Klebsiella pneumoniae were tested for a correlation between tigecycline MIC and expression of ramA by using real-time PCR...
  85. pmc Emergence of multidrug-resistant Klebsiella pneumoniae isolates producing VIM-4 metallo-beta-lactamase, CTX-M-15 extended-spectrum beta-lactamase, and CMY-4 AmpC beta-lactamase in a Tunisian university hospital
    Sonia Ktari
    Laboratoire de Microbiologie, CHU Habib Bourguiba, Sfax, Tunisie
    Antimicrob Agents Chemother 50:4198-201. 2006
    b>Klebsiella pneumoniae clinical isolates resistant to carbapenems were recovered from 11 patients in the hospital of Sfax, Tunisia...
  86. ncbi Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes
    Wen Liang Yu
    Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan
    Diagn Microbiol Infect Dis 62:1-6. 2008
    ..allS (associated with allantoin metabolism), and K1/K2 capsules are important virulence determinants in Klebsiella pneumoniae for liver abscesses. We determined the prevalence of these virulence factors of 50 nonrepeat K...
  87. ncbi Characteristics of aac(6')-Ib-cr gene in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from Chungnam area
    So Youn Shin
    Department of Laboratory Medicine, Chungnam National University College of Medicine, Daejeon, Korea
    Korean J Lab Med 29:541-50. 2009
    ..We aim to investigate the prevalence and characteristics of concomitant aac(6')-Ib-cr and qnr expression in ESBL-producing Escherichia coli and Klebsiella pneumoniae in Korea.
  88. pmc In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae
    Azza Elemam
    Department of Infectious Diseases, St Vincent Medical Center, New York, NY 10011, USA
    J Clin Microbiol 48:3558-62. 2010
    Since carbapenemase-producing Klebsiella pneumoniae strains were first reported in North Carolina, these highly resistant organisms have been isolated with increasing frequency, especially in the New York City area...
  89. ncbi Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor
    Susanne Zamze
    Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, United Kingdom
    J Biol Chem 277:41613-23. 2002
    ..from Streptococcus pneumoniae and to the lipopolysaccharides, but not capsular polysaccharides, from Klebsiella pneumoniae. Binding was Ca(2+)-dependent and inhibitable with d-mannose...
  90. ncbi Genetic determinants of capsular serotype K1 of Klebsiella pneumoniae causing primary pyogenic liver abscess
    Yi Ping Chuang
    Department of Microbiology, National Taiwan University College of Medicine, and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Infect Dis 193:645-54. 2006
    Primary pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae is an emerging infectious disease. Capsular serotype K1 and the magA gene have been reported to be associated with this disease.
  91. ncbi Epidemiological investigation of fluoroquinolone resistance in infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae
    E Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 33:1288-94. 2001
    The incidence of infections due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae (ESBL-EK) has increased markedly in recent years...
  92. ncbi Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess
    Susan Shin Jung Lee
    Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Clin Infect Dis 47:642-50. 2008
    Primary liver abscess caused by Klebsiella pneumoniae is an infection that is emerging worldwide and that is associated with severe morbidity and considerable mortality.
  93. ncbi Klebsiella pneumoniae MrkD-mediated biofilm formation on extracellular matrix- and collagen-coated surfaces
    Jennifer Jagnow
    Department of Microbiology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Microbiology 149:2397-405. 2003
    The type 3 fimbriae of Klebsiella pneumoniae are comprised of the major fimbrial subunit (MrkA) and the adhesin (MrkD) that has previously been shown to mediate binding to collagen...
  94. ncbi Genetically similar isolates of Klebsiella pneumoniae serotype K1 causing liver abscesses in three continents
    Jane F Turton
    Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Med Microbiol 56:593-7. 2007
    ..the Klebsiella K serotype reference strains and in isolates of the K1 serotype of Klebsiella pneumoniae from the UK, Hong Kong, Israel, Taiwan and Australia...
  95. ncbi Klebsiella pneumoniae type 3 pili facilitate adherence and biofilm formation on abiotic surfaces
    Patrick Di Martino
    Laboratoire ERRMECe équipe Microbiologie, U F R Sciences et Techniques, 95302 Cergy Pontoise, France
    Res Microbiol 154:9-16. 2003
    The role of type 1 and type 3 pili in mediating Klebsiella pneumoniae colonization of inert surfaces was assessed by analysis of 26 clinical, 7 water distribution system and four reference strains...
  96. pmc Prevalence and significance of a negative extended-spectrum beta-lactamase (ESBL) confirmation test result after a positive ESBL screening test result for isolates of Escherichia coli and Klebsiella pneumoniae: results from the SENTRY Asia-Pacific Surveil
    Jan M Bell
    Women s and Children s Hospital, Adelaide, South Australia 5006, Australia
    J Clin Microbiol 45:1478-82. 2007
    ..Laboratory Standards Institute methods has been a common occurrence among isolates of Escherichia coli and Klebsiella pneumoniae in the SENTRY Antimicrobial Surveillance Program in the Asia-Pacific region...
  97. ncbi Genomic heterogeneity in Klebsiella pneumoniae strains is associated with primary pyogenic liver abscess and metastatic infection
    Li Chen Ma
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Infect Dis 192:117-28. 2005
    Primary pyogenic liver abscess (PLA) with septic complication by Klebsiella pneumoniae is an emerging infectious disease.
  98. ncbi Dual function of the long pentraxin PTX3 in resistance against pulmonary infection with Klebsiella pneumoniae in transgenic mice
    Adriana C Soares
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas ICB, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627 Pampulha, 31270 901 Belo Horizonte MG, Brazil
    Microbes Infect 8:1321-9. 2006
    ..function of PTX3 was investigated in a model of pulmonary infection caused by the Gram-negative bacterium Klebsiella pneumoniae. Transgenic mice expressing multiple copies of PTX3 under the control of its own promoter were used to ..
  99. ncbi Effect of subinhibitory concentrations of cumin (Cuminum cyminum L.) seed essential oil and alcoholic extract on the morphology, capsule expression and urease activity of Klebsiella pneumoniae
    Safoura Derakhshan
    Department of Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Int J Antimicrob Agents 32:432-6. 2008
    ..The aim of this work was to study the activity of cumin seed essential oil and alcoholic extract against Klebsiella pneumoniae ATCC 13883 and clinical K...
  100. pmc RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43
    H Y Cheng
    Department of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Republic of China
    J Bacteriol 192:3144-58. 2010
    Sequence analysis of the large virulence plasmid pLVPK in Klebsiella pneumoniae CG43 revealed the presence of another mucoid factor encoding gene rmpA besides rmpA2...
  101. ncbi Comparison of pyogenic liver abscess caused by non-Klebsiella pneumoniae and Klebsiella pneumoniae
    Ching Cheng Yang
    Division of Infectious Disease, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, ROC
    J Microbiol Immunol Infect 37:176-84. 2004
    ..Abscesses caused by Klebsiella pneumoniae accounted for 69% (171) of cases. Abscesses caused by K...

Research Grants62

  1. Targeting superbugs: discovery and development of new broad-spectrum lipopeptides
    Jian Li; Fiscal Year: 2013
    ..of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Enterobacter species, Enterococcus faecium and Staphyloccocus aureus...
  2. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle M Zerr; Fiscal Year: 2013
    ..We propose to study antibiotic resistance in Enterobacteriaceae bacteria (such as Escherichia coli and Klebsiella pneumoniae) that produce urinary tract and bloodstream infections in children, by analyzing clinical isolates from 4 ..
  3. Exploiting deep ocean biology for biomedical discovery
    David C Rowley; Fiscal Year: 2011
    ..resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Thus, this project will focus on finding antibiotics against the most problematic clinical pathogens...
  4. Challenges in beta-Lactamase Mediated Resistance
    Robert A Bonomo; Fiscal Year: 2013
    ..These [unreadable]-lactamases are found in ceftazidime resistant Klebsiella pneumoniae, Escherichia coli, Enterobacter spp., Acinetobacter baumannii, and Pseudomonas aeruginosa...
  5. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013
    ..As a model to elucidate the basic host defense mechanisms, we have focused on a primary pathogen, Klebsiella pneumoniae because this extracellular Gram-negative bacterium causes severe pneumonia;and the extensive spread of ..
  6. Innovative technologies to effectively treat Multi-drug resistant and/or biofilm-
    Jie Wen; Fiscal Year: 2010
    ..confirmed the emergence of multi-drug resistant bacteria (MDR) such as Acinetobacter baumannii, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, and multi-drug resistant Pseudomonas aeruginosa...
  7. Optimization of novel pyranopyridine efflux pump inhibitors
    Son Truong Nguyen; Fiscal Year: 2013
    ..antibiotics against Escherichia coli, Shigella flexneri, Salmonella enterica, Enterobacter cloacae, and Klebsiella pneumoniae by inhibiting the major efflux pump in these organisms (AcrA-AcrB-TolC)...
  8. Identification of genes essential for survival of hypervirulent Kleb. pneumoniae
    Thomas A Russo; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): A new, hypervirulent clinical variant of Klebsiella pneumoniae (hvKP) has emerged over the last decade...
  9. RmpA, a unique virulence regulator in emerging Klebsiella pneumoniae
    Valley J Stewart; Fiscal Year: 2012
    ..Although relatively little-studied, Klebsiella pneumoniae nevertheless is a notorious nosocomial pathogen responsible for widespread dissemination of antibiotic ..
  10. Biomechanics of Blood Stream Infections
    John G Younger; Fiscal Year: 2012
    ..Staphylococcus epidermidis and Klebsiella pneumoniae are common causes of intravascular catheter infection, in part due to their production of biofilms that ..
  11. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2013
    ..will be on the organism Mycobacterium tuberculosis;however, the Gram-negative Acinetobacter baumannii and Klebsiella pneumoniae will also be pursued...
  12. Antibody Targeting of KPC and NDM1
    Brad J Spellberg; Fiscal Year: 2013
    ..For example, infections caused by XDR, KPC-expressing Klebsiella pneumoniae have spread across the US and are associated with a 50% mortality rate...
  13. Novel Vaccines To Evoke Bladder Mucosal Immunity
    David J Klumpp; Fiscal Year: 2010
    ..of community-acquired UTIs, but diverse bacteria such as Proteus mirabilis, Pseudomonas aeruginosa, and Klebsiella pneumoniae are often associated with complicated UTIs...
  14. POINT OF CARE DIAGNOSTICS FOR URINARY TRACT INFECTION
    KUMAR SUBRAMANIAN; Fiscal Year: 2012
    ..During PHASE II we will expand the menu to include for the detection of other organisms including Klebsiella pneumoniae, Proteus mirabilis, Enterococcus sp., Pseudomonas aeruginosa...
  15. Roles of IL-17-induced gene expression in airway epithelial host defense
    Reen Wu; Fiscal Year: 2013
    ..To test this hypothesis, the well-established Klebsiella pneumoniae and the clinically relevant Pseudomonas aeruginosa infection mouse models will be used...
  16. The Use of Polyamines in Treatment of Multidrug-Resistant Gram-Negative Pathogens
    Dong Hyeon Kwon; Fiscal Year: 2013
    ..pathogens associated healthcare-infections and nosocomial outbreaks are Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii...
  17. The molecular basis of epidemic blaKPC Klebsiella pneumoniae and Enterobacteriace
    BARRY NEAL KREISWIRTH; Fiscal Year: 2010
    ..provided by applicant): Recent reports indicating a rise in infections caused by carbapenem-resistant Klebsiella pneumoniae (KPC) in the United States and elsewhere have alerted clinicians, infection control teams and public ..
  18. Synthetic lethality of bicyclomycin
    KARL A DRLICA; Fiscal Year: 2013
    ..However, co-treatment of E. coli, Klebsiella pneumoniae, and Acinetobacter baumannii with bicyclomycin plus a second inhibitor of gene expression (e.g...
  19. The molecular basis of the epidemic blaKPC gene Klebsiella
    BARRY NEAL KREISWIRTH; Fiscal Year: 2013
    ..provided by applicant): Recent reports indicating a rise in infections caused by carbapenem- resistant Klebsiella pneumoniae (KPC) in the United States, specifically the New York metropolitan area, and elsewhere have alerted ..
  20. Molecular Pathogenesis of Klebsiella Pneumoniae
    Steven Clegg; Fiscal Year: 2010
    b>Klebsiella pneumoniae is an opportunistic pathogen frequently implicated in respiratory and urinary tract infections of hospitalized patients...
  21. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    ..pyrrhocoricin analog is currently studied for its ability to protect mice against systemic and local Klebsiella pneumoniae, Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis and Salmonella typhimurium infections...
  22. Differences in infecting and colonizing Enterobacteriaceae from short-course vs s
    Scott J Weissman; Fiscal Year: 2013
    ..proportions of children with gastrointestinal colonization by antibiotic-resistant Escherichia coli and/or Klebsiella pneumoniae. Thus, subjects will have stool samples obtained for bacterial culture at enrollment visit (#1;day 4-6) ..
  23. Molecular Archaeology: Vintage Beta Lactams for Resistant Gram Negative Infectio
    Marvin J Miller; Fiscal Year: 2013
    ..stable to most Class A and Class C beta-lactamases, are susceptible to Class B enzymes as well as emerging Klebsiella pneumoniae carbapenemase (KPC) Class A enzymes...
  24. IL-23 / Il-17 and Lung Host Defense
    Jay Kolls; Fiscal Year: 2009
    ..Preliminary data from our laboratory using a murine model of Klebsiella pneumoniae infection has shown that bacterial deposition in the lung results in the release of the T-cell derived ..
  25. Redesign of the Carbapenem Scaffold
    Bret M Benton; Fiscal Year: 2012
    ..of both carbapenem-susceptible as well as carbapenem-resistant strains, including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii isolates...
  26. Clinical and Molecular Epidemiology of Multidrug-Resistant Organisms in a Communi
    Deverick John Anderson; Fiscal Year: 2013
    ..coli, MDR-Klebsiella pneumoniae, or methicillin-resistant Staphylococcus aureus (MRSA) in a community hospital to patients in a tertiary ..
  27. Multi-Drug Resistant Urinary Tract Infections in Ambulatory Settings
    Ebbing Lautenbach; Fiscal Year: 2012
    ..g., Escherichia coli, Klebsiella pneumoniae) have been noted over the past decade...
  28. The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 &NDM-1
    Robert A Bonomo; Fiscal Year: 2013
    ..carbapenemases are emerging in Klebsiella and are a major threat to our antibiotic armamentarium: the Klebsiella pneumoniae carbapenemase (KPC-2), and the New Delhi Metallo-[unreadable]-lactamase (NDM-1 MBL)...
  29. Interruption of Signaling-Mediated Bacterial Persistent Infections
    Laurence G Rahme; Fiscal Year: 2013
    ..aeruginosa in human infections and similarly form AT/P cells (i.e. Acinetobacter baumannii, Klebsiella pneumoniae, and Burkholderia species) will be tested in mono- and polymicrobial planktonic and biofilm settings...
  30. BACTERIAL UREASE IN THE CATHETERIZED URINARY TRACT
    HARRY MOBLEY; Fiscal Year: 1990
    ..from the catheterized urinary tract including Providencia stuartii Proteus mirabilis, Morganella morganii, Klebsiella pneumoniae, and Providencia rettgeri with respect to DNA homology, molecular weight, subunit composition, metal ion ..
  31. Carbapenem-Resistant Klebsiella Pneumoniae in Long-Term Acute Care Hospitals
    Jennifer Han; Fiscal Year: 2013
    ..In this proposal, the candidate will elucidate the epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in the LTACH setting...
  32. REGULATION BY THE ESCHERICHIA COLI SMALL RNA, DSRA
    DARREN SLEDJESKI; Fiscal Year: 2002
    DsrA is a small, stable, untranslated RNA that is conserved between Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium. DsrA RNA regulates two different global regulatory networks...
  33. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa, Acinetobacter species, and Klebsiella pneumoniae are emerging pathogens that are increasingly the cause of a variety of serious infections in hospitalized ..
  34. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..and its designed analogs kill (-lactam-, tetracycline- and aminoglycoside-resistant Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, and Haemophilus influenzae clinical isolates, among many others, in nanomolar or ..
  35. Markers predicting response to therapy for KPC-producing Klebsiella pneumoniae
    Yohei Doi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Klebsiella pneumoniae arbapenemase-producing K. pneumoniae (KPC-Kp) has emerged as an important nosocomial pathogen that is associated with high mortality and treatment failure rates...
  36. CHIROPTICAL SPECTROSCOPY OF METALLOPROTEINS
    Philip Stephens; Fiscal Year: 1990
    ..metalloproteins to be studied include the iron-sulfur (Fe-S) proteins: Desulfovibrio vulgaris hydrogenase, Klebsiella pneumoniae pyruvate-flavodoxin oxidoreductase, and Micrococcus aerogenes ferredoxin and the nickel-iron-sulfur enzyme:..
  37. Innate immune responses to microbial flora
    Eric G Pamer; Fiscal Year: 2013
    ..to resist colonization and infection by Vancomycin-resistant enterococcus (VRE) and carbapenem-resistant Klebsiella pneumoniae (KPC), two highly antibiotic resistant bacteria that are emerging causes of severe, frequently lethal ..
  38. Detecting Carbapenem and Quinolone Resistance in Klebsiella pneumoniae using PCR/
    Robert A Bonomo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Among Gram-negative bacteria, nosocomial infections by Klebsiella pneumoniae that are resistant to carbapenems and quinolones are rapidly becoming a global problem...
  39. Modulation of innate immunity in lung transplantation
    Sadis Matalon; Fiscal Year: 2005
    ..NO metabolism, and nitrotyrosine in the BAL of these patients; (3) Assess the extent of pathogen killing (Klebsiella pneumoniae, a gram negative bacterium and Staphylococcus aureus, a gram positive bacterium) by AMs isolated from the ..
  40. The Pseudomonas Aeruginosa Biofilm Dispersion Response
    David Davies; Fiscal Year: 2009
    ..aerugjnosa, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Streptococcus pyogenes, Staphylococcus aureus, and Candida albicans...
  41. MAST CELLS IN PULMONARY INFLAMMATION
    SOMAN ABRAHAM; Fiscal Year: 1999
    ..We have discovered that mast cells can interact with the pulmonary pathogen Klebsiella pneumoniae (Kp) through a mannose-binding protein (FimH) borne on the tips of surface organelles of these bacteria...
  42. Gamma Delta T Cells in Anti-Bacterial Host Defense
    Thomas Moore; Fiscal Year: 2005
    b>Klebsiella pneumoniae is a leading cause of community-acquired and nosocomial infections. Moreover, K pneumoniae is the second leading cause of nosocomial gram negative bacteremia...
  43. Mast Cells and the Host Response in the Lung
    Paul Wolters; Fiscal Year: 2007
    ..knockout mice and determining the physiologic mechanism for survival following inoculation with Klebsiella pneumoniae. #2...
  44. INTERACTIONS OF THE SIGNAL TRANSDUCTION PROTEIN GLNK
    Alexander Ninfa; Fiscal Year: 2002
    ..GlnK regulates the activity of the NifA protein controlling nitrogenase synthesis when NifA and NifL from Klebsiella pneumoniae are introduced into E. coli along with a nif gene reporter. PII lacks the ability to regulate NifA...
  45. BODY TEMPERATURE AND REGULATING HOST DEFENSES
    Jeffrey Hasday; Fiscal Year: 2001
    ..to directly determine the following potential effects of core temperatures changes in mice infected with Klebsiella pneumoniae, a clinically relevant and virulent bacterial pathogen: (1) determine if febrile core temperatures enhance ..
  46. MICROBIAL ENZYMES INVOLVED IN NITROGEN METABOLISM
    LEONARD MORTENSON; Fiscal Year: 1980
    ..the in vitro efficiency of ATP utilization by the nitrogen-fixing system of Clostridium pasteurianum, Klebsiella pneumoniae and Azotobacter vinelandii. 2...
  47. Alcohol, Pulmonary Cytokines, and Host Defense
    Kyle Happel; Fiscal Year: 2009
    ..Specifically, alcohol's effect on IL-23 and IL-27 expression during pulmonary infection with Klebsiella pneumoniae will be studied...
  48. SERINE PROTEINASES & LUNG HOST DEFENSE AGAINST BACTERIA
    Azzaq Belaaouaj; Fiscal Year: 2004
    ..We have observed that elastin peptides from NE-digested human lung elastin are bactericidal for Klebsiella pneumoniae in vitro...
  49. SALIVARY AND TRACHEOBRONCHIAL MUCINS IN DISEASE
    MOLAKALA REDDY; Fiscal Year: 1991
    ..125 I-MG1 to fresh isolates of Streptococcus pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterobacter species obtained from patients with documented respiratory infection...
  50. FUNCTIONS OF NIF ASSOCIATED PROTEINS
    Gary Roberts; Fiscal Year: 1990
    The molecular analysis of the nitrogen fixation (nif) system of Klebsiella pneumoniae is of relevance both for the basic scientific questions it addresses as well as for its implications for the understanding of the more agronomically ..
  51. DEFENSE MECHANISMS OF THE LUNG
    Alan Pierce; Fiscal Year: 1980
    ..between defense mechanisms of the lung and the important human pathogens Streptococcus pneumoniae, Klebsiella pneumoniae, Straphylococcus aureus, and Pseudomonas aeruginosa...
  52. BIOMEDICAL RESEARCH PROGRAM
    JULIETTE BELL; Fiscal Year: 2000
    ..Characterization of ceftazidime resistance in Klebsiella pneumoniae (Raynor) 4. Theoretical studies on elasticity of microemulsions (Wu)...
  53. BINDING OF KLEBSIELLA FIMBRIAE TO RESPIRATORY TISSUE
    Steven Clegg; Fiscal Year: 2002
    The type 3 fimbrial adhesin (MrkD) of Klebsiella pneumoniae mediates binding of the bacteria to specific types of collagen...
  54. PATHOPHYSIOLOGICAL BIOCHEMICAL CHANGES OF THERMAL INJURY
    Fiemu Nwariaku; Fiscal Year: 2009
    ..decontamination of the digestive tract on postburn responses to subsequent sepsis (IT Streptococcus or Klebsiella pneumoniae) will be examined...
  55. Neutrophil-Microvascular Endothelial Cell Interactions in a Chronic Ethanol Model
    SONJA TANG; Fiscal Year: 2007
    ..In addition, we will investigate the effects of Klebsiella pneumoniae infection on neutrophil-endothelial cell interactions...
  56. INITIATION OF DNA REPLICATION IN E. COLI
    Andrew Wright; Fiscal Year: 1990
    ..looking at the effects of total shut-off of dnaA expression on initiation, and cloning and DNA sequence analysis of the dnaA gene from Klebsiella pneumoniae, a comparative study to see which regions of the dnaA gene have been conserved.
  57. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  59. REGULATION OF MICROBIAL NITROGEN METABOLISM
    ROBERT BENDER; Fiscal Year: 2006
    ..In particular, a lysine-sensitive positive effector of gdhA expression will be characterized and used as a model for the characterization of other positive effectors of gdhA. ..
  60. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
  61. 37th Annual Meeting of the Society for Leukocyte Biology
    Joshua Fierer; Fiscal Year: 2004
    ..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
  62. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..