bacillus thuringiensis

Summary

Summary: A species of gram-positive bacteria which may be pathogenic for certain insects. It is used for the biological control of the Gypsy moth.

Top Publications

  1. pmc Field-evolved resistance to Bt maize by western corn rootworm
    Aaron J Gassmann
    Department of Entomology, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e22629. 2011
  2. ncbi Bacillus thuringiensis: a century of research, development and commercial applications
    Georgina Sanahuja
    Department of Plant Production and Forestry Science, ETSEA, University of Lleida, Lleida, Spain
    Plant Biotechnol J 9:283-300. 2011
  3. ncbi Discovery and characterization of field resistance to Bt maize: Spodoptera frugiperda (Lepidoptera: Noctuidae) in Puerto Rico
    Nicholas P Storer
    Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268, USA
    J Econ Entomol 103:1031-8. 2010
  4. ncbi Insect resistance to Bt crops: evidence versus theory
    Bruce E Tabashnik
    Department of Entomology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Biotechnol 26:199-202. 2008
  5. pmc Bacillus thuringiensis: A story of a successful bioinsecticide
    Alejandra Bravo
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca 62250, Morelos, Mexico
    Insect Biochem Mol Biol 41:423-31. 2011
  6. pmc Differential alteration of two aminopeptidases N associated with resistance to Bacillus thuringiensis toxin Cry1Ac in cabbage looper
    Kasorn Tiewsiri
    Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA
    Proc Natl Acad Sci U S A 108:14037-42. 2011
  7. pmc Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control
    Alejandra Bravo
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo, Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Toxicon 49:423-35. 2007
  8. ncbi Areawide suppression of European corn borer with Bt maize reaps savings to non-Bt maize growers
    W D Hutchison
    Department of Entomology, University of Minnesota, St Paul, MN 55108, USA
    Science 330:222-5. 2010
  9. ncbi Effects of Bt cotton and crylac toxin on survival and development of pink bollworm (Lepidoptera: Gelechiidae)
    Y B Liu
    Department of Entomology, University of Arizona, Tucson 85721, USA
    J Econ Entomol 94:1237-42. 2001
  10. pmc Increased frequency of pink bollworm resistance to Bt toxin Cry1Ac in China
    Peng Wan
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, People s Republic of China
    PLoS ONE 7:e29975. 2012

Research Grants

Detail Information

Publications353 found, 100 shown here

  1. pmc Field-evolved resistance to Bt maize by western corn rootworm
    Aaron J Gassmann
    Department of Entomology, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e22629. 2011
    Crops engineered to produce insecticidal toxins derived from the bacterium Bacillus thuringiensis (Bt) are planted on millions of hectares annually, reducing the use of conventional insecticides and suppressing pests...
  2. ncbi Bacillus thuringiensis: a century of research, development and commercial applications
    Georgina Sanahuja
    Department of Plant Production and Forestry Science, ETSEA, University of Lleida, Lleida, Spain
    Plant Biotechnol J 9:283-300. 2011
    b>Bacillus thuringiensis (Bt) is a soil bacterium that forms spores during the stationary phase of its growth cycle...
  3. ncbi Discovery and characterization of field resistance to Bt maize: Spodoptera frugiperda (Lepidoptera: Noctuidae) in Puerto Rico
    Nicholas P Storer
    Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268, USA
    J Econ Entomol 103:1031-8. 2010
    ..In response to this resistance incident, the technology providers have stopped commercial sales of TC1507 maize in Puerto Rico pending potential reversion to susceptibility...
  4. ncbi Insect resistance to Bt crops: evidence versus theory
    Bruce E Tabashnik
    Department of Entomology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Biotechnol 26:199-202. 2008
    Evolution of insect resistance threatens the continued success of transgenic crops producing Bacillus thuringiensis (Bt) toxins that kill pests...
  5. pmc Bacillus thuringiensis: A story of a successful bioinsecticide
    Alejandra Bravo
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca 62250, Morelos, Mexico
    Insect Biochem Mol Biol 41:423-31. 2011
    b>Bacillus thuringiensis (Bt) bacteria are insect pathogens that rely on insecticidal pore forming proteins known as Cry and Cyt toxins to kill their insect larval hosts...
  6. pmc Differential alteration of two aminopeptidases N associated with resistance to Bacillus thuringiensis toxin Cry1Ac in cabbage looper
    Kasorn Tiewsiri
    Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA
    Proc Natl Acad Sci U S A 108:14037-42. 2011
    The soil bacterium Bacillus thuringiensis (Bt) is the most successfully used biopesticide in agriculture, and its insecticidal protein genes are the primary transgenes used for insect control in transgenic crops...
  7. pmc Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control
    Alejandra Bravo
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo, Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Toxicon 49:423-35. 2007
    b>Bacillus thuringiensis Crystal (Cry) and Cytolitic (Cyt) protein families are a diverse group of proteins with activity against insects of different orders--Lepidoptera, Coleoptera, Diptera and also against other invertebrates such as ..
  8. ncbi Areawide suppression of European corn borer with Bt maize reaps savings to non-Bt maize growers
    W D Hutchison
    Department of Entomology, University of Minnesota, St Paul, MN 55108, USA
    Science 330:222-5. 2010
    Transgenic maize engineered to express insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) has become widely adopted in U.S. agriculture. In 2009, Bt maize was planted on more than 22...
  9. ncbi Effects of Bt cotton and crylac toxin on survival and development of pink bollworm (Lepidoptera: Gelechiidae)
    Y B Liu
    Department of Entomology, University of Arizona, Tucson 85721, USA
    J Econ Entomol 94:1237-42. 2001
    We evaluated the effects of Bacillus thuringiensis (Bt) toxin CrylAc on survival and development of a susceptible strain and laboratory-selected resistant strains of pink bollworm, Pectinophora gossypiella (Saunders)...
  10. pmc Increased frequency of pink bollworm resistance to Bt toxin Cry1Ac in China
    Peng Wan
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, People s Republic of China
    PLoS ONE 7:e29975. 2012
    Transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) kill some key insect pests, but evolution of resistance by pests can reduce their efficacy...
  11. ncbi Suppressing resistance to Bt cotton with sterile insect releases
    Bruce E Tabashnik
    Department of Entomology, University of Arizona, Tucson, Arizona, USA
    Nat Biotechnol 28:1304-7. 2010
    Genetically engineered crops that produce insecticidal toxins from Bacillus thuringiensis (Bt) are grown widely for pest control. However, insect adaptation can reduce the toxins' efficacy...
  12. ncbi Efficacy and efficiency of new Bacillus thuringiensis var israelensis and Bacillus sphaericus formulations against Afrotropical anophelines in Western Kenya
    Ulrike Fillinger
    International Centre of Insect Physiology and Ecology ICIPE, Mbita Point, Kenya
    Trop Med Int Health 8:37-47. 2003
    ....
  13. pmc Frequency of resistance to Bacillus thuringiensis in field populations of pink bollworm
    B E Tabashnik
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 97:12980-4. 2000
    Strategies for delaying pest resistance to genetically modified crops that produce Bacillus thuringiensis (Bt) toxins are based primarily on theoretical models...
  14. ncbi Detection and characterization of the novel bacteriocin entomocin 9, and safety evaluation of its producer, Bacillus thuringiensis ssp. entomocidus HD9
    A Cherif
    Laboratoire de Microbiologie, Departement de Biologie, Faculte des Sciences de Tunis, Campus Universitaire, Tunis, Tunisia
    J Appl Microbiol 95:990-1000. 2003
    To identify and characterize new bacteriocins from a collection of 41 strains belonging to 27 subspecies of Bacillus thuringiensis, and to evaluate the safety of the producers.
  15. ncbi The hidden lifestyles of Bacillus cereus and relatives
    G B Jensen
    National Institute of Occupational Health, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    Environ Microbiol 5:631-40. 2003
    Bacillus cereus sensu lato, the species group comprising Bacillus anthracis, Bacillus thuringiensis and B. cereus (sensu stricto), has previously been scrutinized regarding interspecies genetic correlation and pathogenic characteristics...
  16. pmc Recommendations for the design of laboratory studies on non-target arthropods for risk assessment of genetically engineered plants
    Jörg Romeis
    Agroscope Reckenholz Tanikon Research Station ART, Reckenholzstr 191, 8046, Zurich, Switzerland
    Transgenic Res 20:1-22. 2011
    ..While we rely heavily on the currently used proteins from Bacillus thuringiensis (Bt) in this discussion, the concepts apply to other arthropod-active proteins...
  17. ncbi A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats
    Malene Schrøder
    Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Food Chem Toxicol 45:339-49. 2007
    ..Nevertheless the experiences from this study lead to the overall conclusion that safety assessment for unintended effects of a GM crop cannot be done without additional test group(s)...
  18. pmc Long-term regional suppression of pink bollworm by Bacillus thuringiensis cotton
    Yves Carriere
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 100:1519-23. 2003
    ..Transgenic crops that produce toxins from Bacillus thuringiensis (Bt) to control insects are grown widely, but rapid evolution of resistance by pests could nullify their ..
  19. ncbi Silencing of midgut aminopeptidase N of Spodoptera litura by double-stranded RNA establishes its role as Bacillus thuringiensis toxin receptor
    R Rajagopal
    International Centre for Genetic Engineering and Biotechnology ICGEB, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110 067, India
    J Biol Chem 277:46849-51. 2002
    Insecticidal crystal proteins of Bacillus thuringiensis bind to receptors in the midgut of susceptible insects leading to pore formation and death of the insect. The identity of the receptor is not clearly established...
  20. pmc An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac toxin
    Linda J Gahan
    Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America
    PLoS Genet 6:e1001248. 2010
    Transgenic crops producing insecticidal toxins from Bacillus thuringiensis (Bt) are commercially successful in reducing pest damage, yet knowledge of resistance mechanisms that threaten their sustainability is incomplete...
  21. pmc WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans
    Chang Shi Chen
    Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 5:e9494. 2010
    ..pathway confers the resistance of Caenorhabditis elegans to cytolitic crystal (Cry) PFTs produced by Bacillus thuringiensis. In contrast to the canonical DAF-2 insulin-like signaling pathway previously defined for aging and ..
  22. ncbi Biochemistry and genetics of insect resistance to Bacillus thuringiensis
    Juan Ferré
    Department of Genetics, University of Valencia, 46110 Burjassot Valencia, Spain
    Annu Rev Entomol 47:501-33. 2002
    b>Bacillus thuringiensis (Bt) is a valuable source of insecticidal proteins for use in conventional sprayable formulations and in transgenic crops, and it is the most promising alternative to synthetic insecticides...
  23. pmc Insecticidal Bacillus thuringiensis silences Erwinia carotovora virulence by a new form of microbial antagonism, signal interference
    Yi Hu Dong
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore 117609
    Appl Environ Microbiol 70:954-60. 2004
    ..Here we report that Bacillus thuringiensis suppressed the quorum-sensing-dependent virulence of plant pathogen Erwinia carotovora through a new form ..
  24. pmc Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins
    Danielle L Huffman
    Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, 92093, USA
    Proc Natl Acad Sci U S A 101:10995-1000. 2004
    ..elegans responds robustly to Cry5B, a member of the pore-forming Crystal toxin family made by Bacillus thuringiensis. This genomic response is distinct from that seen with a different stressor, the heavy metal cadmium...
  25. ncbi The transcriptome of Spodoptera exigua larvae exposed to different types of microbes
    Laura Pascual
    Instituto de Conservacion y Mejora de la Agrodiversidad Valenciana COMAV, Universidad Politecnica de Valencia, Camino de Vera s n, Valencia, Spain
    Insect Biochem Mol Biol 42:557-70. 2012
    ..by exposing larvae to different pathogenic and non-pathogenic microbial agents such as the bacteria Bacillus thuringiensis, Micrococcus luteus, and Escherichia coli, the yeast Saccharomyces cerevisiae, and the S...
  26. pmc tRNA 5'-end repair activities of tRNAHis guanylyltransferase (Thg1)-like proteins from Bacteria and Archaea
    Bhalchandra S Rao
    Department of Biochemistry and Center for RNA Biology and Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 39:1833-42. 2011
    ..Here, we report that TLPs from Bacillus thuringiensis (BtTLP) and Methanosarcina acetivorans (MaTLP) display biochemical properties consistent with a prominent ..
  27. ncbi Effects of MON810 Bt field corn on adult emergence of Helicoverpa zea (Lepidoptera: Noctuidae)
    T A Horner
    USDA, APHIS, PPQ, 4700 River Road, Unit 133, Riverdale, MD 20737, USA
    J Econ Entomol 96:925-30. 2003
    ..This, in turn, may contribute to the evolution of resistance to Bt corn...
  28. pmc Role of receptors in Bacillus thuringiensis crystal toxin activity
    Craig R Pigott
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    Microbiol Mol Biol Rev 71:255-81. 2007
    b>Bacillus thuringiensis produces crystalline protein inclusions with insecticidal or nematocidal properties. These crystal (Cry) proteins determine a particular strain's toxicity profile...
  29. pmc Asymmetrical cross-resistance between Bacillus thuringiensis toxins Cry1Ac and Cry2Ab in pink bollworm
    Bruce E Tabashnik
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 106:11889-94. 2009
    Transgenic crops producing Bacillus thuringiensis (Bt) toxins kill some key insect pests and can reduce reliance on insecticide sprays. Sustainable use of such crops requires methods for delaying evolution of resistance by pests...
  30. ncbi Binding analyses of Cry1Ab and Cry1Ac with membrane vesicles from Bacillus thuringiensis-resistant and -susceptible Ostrinia nubilalis
    Huarong Li
    Department of Entomology, Kansas State University, Manhattan, KS 66506, USA
    Biochem Biophys Res Commun 323:52-7. 2004
    The binding properties of Bacillus thuringiensis toxins to brush border membrane vesicles of Dipel-resistant and -susceptible Ostrinia nubilalis larvae were compared using ligand-toxin immunoblot analysis, surface plasmon resonance (SPR), ..
  31. pmc A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum
    Michael Cappello
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:15154-9. 2006
    Crystal (Cry) proteins produced by the soil bacterium Bacillus thuringiensis (Bt) are harmless to vertebrates, but they are highly toxic to insects and nematodes...
  32. ncbi Increase in midgut microbiota load induces an apparent immune priming and increases tolerance to Bacillus thuringiensis
    Patricia Hernández-Martínez
    Department of Genetics, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Environ Microbiol 12:2730-7. 2010
    ..that are typical reported for immune primed insects, such as increased tolerance to pathogens (Bacillus thuringiensis in our case), fitness-cost associated to the immune status, and maternal transmission of the immune status...
  33. ncbi Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: a critical review
    Vincent Vachon
    Groupe d étude des protéines membranaires, Universite de Montreal, P O Box 6128, Centre Ville Station, Montreal, Quebec, Canada H3C 3J7
    J Invertebr Pathol 111:1-12. 2012
    b>Bacillus thuringiensis (Bt) Cry toxins constitute the active ingredient in the most widely used biological insecticides and insect-resistant transgenic crops...
  34. pmc Bacillus thuringiensis: a genomics and proteomics perspective
    Mohamed A Ibrahim
    Biological Targets, Inc, Pilot Point, TX, USA
    Bioeng Bugs 1:31-50. 2010
    b>Bacillus thuringiensis (Bt) is a unique bacterium in that it shares a common place with a number of chemical compounds which are used commercially to control insects important to agriculture and public health...
  35. ncbi Development, survival and fitness performance of Helicoverpa zea (Lepidoptera: Noctuidae) in MON810 Bt field corn
    T A Horner
    USDA, APHIS, PPQ, 4700 River Road, Unit 133, Riverdale, MD 20737, USA
    J Econ Entomol 96:914-24. 2003
    ..expressing Bacillus thuringiensis variety kurstaki (Bt) Cry1Ab endotoxins were compared with non-Bt ears at four geographic locations over ..
  36. ncbi Cry1A toxins of Bacillus thuringiensis bind specifically to a region adjacent to the membrane-proximal extracellular domain of BT-R(1) in Manduca sexta: involvement of a cadherin in the entomopathogenicity of Bacillus thuringiensis
    J A Dorsch
    Center for Biotechnology and Bioinformatics, The University of Texas at Dallas, P O Box 830688, FO31, Richardson, TX 75083 0688, USA
    Insect Biochem Mol Biol 32:1025-36. 2002
    Many subspecies of the soil bacterium Bacillus thuringiensis produce various parasporal crystal proteins, also known as Cry toxins, that exhibit insecticidal activity upon binding to specific receptors in the midgut of susceptible insects...
  37. ncbi Life history attributes of Indian meal moth (Lepidoptera: Pyralidae) and Angoumois grain moth (Lepidoptera: Gelechiidae) reared on transgenic corn kernels
    J D Sedlacek
    Community Research Service, Kentucky State University, Frankfort 40601, USA
    J Econ Entomol 94:586-92. 2001
    ..kernels (i.e., grain) of some Bacillus thuringiensis Berliner (Bt) corn hybrids containing CrylAb Bt delta-endotoxin have on life history attributes of Indian ..
  38. ncbi Thuricin 7: a novel bacteriocin produced by Bacillus thuringiensis BMG1.7, a new strain isolated from soil
    A Cherif
    Laboratoire de Microbiologie, Departement de Biologie, Faculte des Sciences de Tunis, Tunisia
    Lett Appl Microbiol 32:243-7. 2001
    ..Detection and identification of new antagonistic activities towards Bacillus cereus and relatives...
  39. ncbi Transgenic Bt-producing Brassica napus: Plutella xylostella selection pressure and fitness of weedy relatives
    Peter Mason
    Agriculture and Agri Food Canada, Eastern Cereal and Oilseed Research Centre, K W Neatby Bldg, Ottawa, Ontario, K1A 0C6, Canada
    Environ Biosafety Res 2:263-76. 2003
    ..napus. Establishment of the Bt trait in wild B. rapa populations may also increase its competitive advantage under high insect pressure...
  40. ncbi The InhA1 metalloprotease allows spores of the B. cereus group to escape macrophages
    Nalini Ramarao
    Unité Génétique Microbienne et Environnement, Institut National de la Recherche Agronomique, La Minière, 78285 Guyancourt Cedex, France
    Cell Microbiol 7:1357-64. 2005
    ..InhA1 from Bacillus thuringiensis also enables Bacillus subtilis to escape from macrophages...
  41. pmc Mutated cadherin alleles from a field population of Helicoverpa armigera confer resistance to Bacillus thuringiensis toxin Cry1Ac
    Yajun Yang
    Department of Entomology, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
    Appl Environ Microbiol 73:6939-44. 2007
    ..Helicoverpa armigera is the major insect pest targeted by cotton genetically engineered to produce the Bacillus thuringiensis toxin (transgenic Bt cotton) in the Old World. The evolution of this pest's resistance to B...
  42. pmc Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thuringiensis in Helicoverpa armigera
    Xinjun Xu
    Department of Entomology, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, People s Republic of China
    Appl Environ Microbiol 71:948-54. 2005
    ..armigera (Hubner) was established from surviving larvae collected from transgenic cotton expressing a Bacillus thuringiensis var...
  43. pmc Bacillus thuringiensis subsp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor
    Claudia Perez
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca 62250, Morelos, Mexico
    Proc Natl Acad Sci U S A 102:18303-8. 2005
    b>Bacillus thuringiensis subsp. israelensis produces crystal proteins, Cry (4Aa, 4Ba, 10Aa, and 11Aa) and Cyt (1Aa and 2Ba) proteins, toxic to mosquito vectors of human diseases...
  44. pmc Increased survival of western corn rootworm on transgenic corn within three generations of on-plant greenhouse selection
    Lisa N Meihls
    Division of Plant Science, 205 Curtis Hall, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 105:19177-82. 2008
    To delay evolution of insect resistance to transgenic crops producing Bacillus thuringiensis (Bt) toxins, nearby "refuges" of host plants not producing Bt toxins are required in many regions...
  45. ncbi The dynamics of cooperative bacterial virulence in the field
    Ben Raymond
    School of Biological Sciences, Royal Holloway University of London, Egham, UK
    Science 337:85-8. 2012
    ..We investigated the sociality of essential virulence factors (crystal toxins) in the pathogen Bacillus thuringiensis using diamondback moth larvae (Plutella xylostella) as hosts...
  46. pmc Comparative proteomic analysis of Aedes aegypti larval midgut after intoxication with Cry11Aa toxin from Bacillus thuringiensis
    Angeles Cancino-Rodezno
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    PLoS ONE 7:e37034. 2012
    Cry toxins produced by Bacillus thuringiensis bacteria are environmentally safe alternatives to control insect pests. They are pore-forming toxins that specifically affect cell permeability and cellular integrity of insect-midgut cells...
  47. pmc Aedes aegypti cadherin serves as a putative receptor of the Cry11Aa toxin from Bacillus thuringiensis subsp. israelensis
    Jianwu Chen
    Department of Cell Biology and Neuroscience, University of California Riverside, Riverside, CA 92521, USA
    Biochem J 424:191-200. 2009
    Cry11Aa of Bacillus thuringiensis subsp. israelensis is the most active toxin to Aedes aegypti in this strain...
  48. pmc Display of biologically functional insecticidal toxin on the surface of lambda phage
    Susana Vilchez
    Department of Biochemistry, Cambridge University, Cambridge, United Kingdom
    Appl Environ Microbiol 70:6587-94. 2004
    The successful use of Bacillus thuringiensis insecticidal toxins to control agricultural pests could be undermined by the evolution of insect resistance...
  49. ncbi Modification of hormonal balance in larvae of the corn borer Sesamia nonagrioides (Lepidoptera: Noctuidae) due to sublethal Bacillus thuringiensis protein ingestion
    Meritxell Pérez-Hedo
    Centre UdL IRTA, Universitat de Lleida, Av Alcalde Rovira Roure 191, 25198 Lleida, Spain
    J Econ Entomol 104:853-61. 2011
    b>Bacillus thuringiensis (Bt) corn, Zea mays L., is highly efficient against the corn borer Sesamia nonagrioides (Lefèbvre) (Lepidoptera: Noctuidae) when the larvae feed only on the transgenic plants...
  50. ncbi Bacillus thuringiensis: an impotent pathogen?
    Ben Raymond
    Department of Zoology, University of Oxford, South Parks Rd, Oxford, OX1 3PS, UK
    Trends Microbiol 18:189-94. 2010
    b>Bacillus thuringiensis (Bt) is an insecticidal bacterium that has successfully been used as a biopesticide for many years...
  51. ncbi Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection
    Liliana Pardo-Lopez
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    FEMS Microbiol Rev 37:3-22. 2013
    b>Bacillus thuringiensis bacteria are insect pathogens that produce different Cry and Cyt toxins to kill their hosts. Here we review the group of three-domain Cry (3d-Cry) toxins...
  52. pmc An engineered chymotrypsin/cathepsin G site in domain I renders Bacillus thuringiensis Cry3A active against Western corn rootworm larvae
    Frederick S Walters
    Syngenta Biotechnology, Inc, Research Triangle Park, NC 27709 2257, USA
    Appl Environ Microbiol 74:367-74. 2008
    ..Cry3A, the first coleopteran-active Bacillus thuringiensis toxin isolated, has not been useful for control of the corn rootworm pest complex...
  53. ncbi Control of mosquitoes in catch basins in Connecticut with Bacillus thuringiensis israelensis, Bacillus sphaericus, [corrected] and spinosad
    John F Anderson
    The Connecticut Agricultural Experiment Station, PO Box 1106, New Haven, CT 06504, USA
    J Am Mosq Control Assoc 27:45-55. 2011
    ..restuans, and Aedes japonicus in northeastern USA. VectoBac CG (Bacillus thuringiensis israelensis [Bti]), VectoLex CG (Bacillus sphaericus [Bs]), and VectoBac 12AS (Bti), each applied at ..
  54. ncbi Occurrence and field densities of Coleoptera in the maize herb layer: implications for Environmental Risk Assessment of genetically modified Bt-maize
    Stefan Rauschen
    Department of Plant Physiology, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany
    Transgenic Res 19:727-44. 2010
    ..Species occurring off-crop, however, can be addressed in a similar fashion as non-target Lepidoptera in Cry1Ab expressing Bt-maize...
  55. ncbi Effects of Bacillus thuringiensis Cry1Ab and Cry3Aa endotoxins on predatory Coleoptera tested through artificial diet-incorporation bioassays
    M Porcar
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Apartado Postal 22085, 46071 Valencia, Spain
    Bull Entomol Res 100:297-302. 2010
    ..we report the results of a bioassay using an artificial diet, suitable for predatory Coleoptera, to supply Bacillus thuringiensis (Bt) solubilized Cry1Ab and Cry3Aa as well as trypsin-activated Cry1Ab to Atheta coriaria and Cryptolaemus ..
  56. ncbi A novel l-isoleucine hydroxylating enzyme, l-isoleucine dioxygenase from Bacillus thuringiensis, produces (2S,3R,4S)-4-hydroxyisoleucine
    Tomohiro Kodera
    Institute of Life Sciences, Ajinomoto Co, Inc, Suzuki cho, Kawasaki shi 210 8681, Japan
    Biochem Biophys Res Commun 390:506-10. 2009
    ..l-isoleucine (l-Ile) hydroxylating activity producing 4-HIL was detected in a cell lysate of Bacillus thuringiensis strain 2e2 AKU 0251 obtained from the mid-late exponential phase of growth...
  57. ncbi Transgenic Drosophila reveals a functional in vivo receptor for the Bacillus thuringiensis toxin Cry1Ac1
    Michael Gill
    Beth Israel Deaconess Medical Center Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Insect Mol Biol 11:619-25. 2002
    The bacterium Bacillus thuringiensis synthesizes toxins (delta-endotoxins) that are highly specific for insects...
  58. pmc Bacillus thuringiensis delta-endotoxin Cry1C domain III can function as a specificity determinant for Spodoptera exigua in different, but not all, Cry1-Cry1C hybrids
    R A de Maagd
    Plant Research International, 6700 AA Wageningen, The Netherlands
    Appl Environ Microbiol 66:1559-63. 2000
    In order to test our hypothesis that Bacillus thuringiensis delta-endotoxin Cry1Ca domain III functions as a determinant of specificity for Spodoptera exigua, regardless of the origins of domains I and II, we have constructed by cloning ..
  59. pmc Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China
    Haonan Zhang
    Key Laboratory of Integrated Management of Crop Diseases and Pests Ministry of Education, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
    Proc Natl Acad Sci U S A 109:10275-80. 2012
    Evolution of pest resistance reduces the efficacy of insecticidal proteins from Bacillus thuringiensis (Bt) used in sprays or in transgenic crops...
  60. ncbi RNA interference of an antimicrobial peptide, gloverin, of the beet armyworm, Spodoptera exigua, enhances susceptibility to Bacillus thuringiensis
    Jihyun Hwang
    Department of Bioresource Sciences, Andong National University, Andong 760 749, Republic of Korea
    J Invertebr Pathol 108:194-200. 2011
    ..The larvae treated with dsRNA were much more susceptible to Bacillus thuringiensis than the control larvae...
  61. pmc Protist-type lysozymes of the nematode Caenorhabditis elegans contribute to resistance against pathogenic Bacillus thuringiensis
    Claudia Boehnisch
    Institute for Evolution and Biodiversity, University of Muenster, Muenster, Germany
    PLoS ONE 6:e24619. 2011
    ..several protist-type lysozyme genes in defence against a nematocidal strain of the Gram-positive bacterium Bacillus thuringiensis. Based on microarray and subsequent qRT-PCR gene expression analysis, we identified protist-type lysozyme ..
  62. pmc Interaction of Bacillus thuringiensis Cry1 and Vip3A proteins with Spodoptera frugiperda midgut binding sites
    Janete A D Sena
    Departamento de Genetica, Facultad de CC Biológicas, Dr Moliner 50, 46100 Burjassot, Valencia, Spain
    Appl Environ Microbiol 75:2236-7. 2009
    ..Vip3A proteins were more toxic than Cry1 proteins. Binding assays showed independent specific binding sites for Cry1 and Vip3A proteins. Cry1Ab and Cry1Fa competed for the same binding sites, whereas Vip3Aa competed for those of Vip3Af...
  63. ncbi The mammalian safety of Bacillus thuringiensis-based insecticides
    J P Siegel
    USDA ARS Horticultural Crops Research Center, 2021 South Peach Avenue, Fresno, California 93727, USA
    J Invertebr Pathol 77:13-21. 2001
    ..Environmental Protection Agency between the years 1961 and 1995 registered 177 products containing viable Bacillus thuringiensis (Bt)...
  64. ncbi Beyond the spore--past and future developments of Bacillus thuringiensis as a biopesticide
    N Crickmore
    School of Life Sciences, University of Sussex, Falmer, Brighton, UK
    J Appl Microbiol 101:616-9. 2006
    Formulated and sporulated cultures of Bacillus thuringiensis (Bt) are widely used as foliar sprays as part of integrated pest management strategies against insect pests of agricultural crops...
  65. ncbi Evaluation of transgenic soybean exhibiting high expression of a synthetic Bacillus thuringiensis cry1A transgene for suppressing lepidopteran population densities and crop injury
    Robert M McPherson
    Department of Entomology, College of Agricultural and Environmental Sciences, University of Georgia Tifton Campus, P O Box 748, Tifton, GA 31793 0748, USA
    J Econ Entomol 102:1640-8. 2009
    Several transgenic lines of soybean, Glycine max (L.) Merr., expressing a synthetic cry1A gene from Bacillus thuringiensis (Bt), were examined in replicated field trials in 2003-2007 for suppression of naturally occurring population ..
  66. pmc Solubilization, activation, and insecticidal activity of Bacillus thuringiensis serovar thompsoni HD542 crystal proteins
    Samir Naimov
    Department of Plant Physiology and Molecular Biology, University of Plovdiv, Plovdiv, Bulgaria
    Appl Environ Microbiol 74:7145-51. 2008
    Cry15Aa protein, produced by Bacillus thuringiensis serovar thompsoni HD542 in a crystal together with a 40-kDa accompanying protein, is one of a small group of nontypical, less well-studied members of the Cry family of insecticidal ..
  67. pmc Effects of two varieties of Bacillus thuringiensis maize on the biology of Plodia interpunctella
    Aiko Gryspeirt
    Biological Control and Spatial Ecology Laboratory LUBIES, CP 160 12, Universite Libre de Bruxelles, Av FD Roosevelt 50, B 1050 Brussels, Belgium
    Toxins (Basel) 4:373-89. 2012
    ..market since 1996, genetically modified plants expressing an insecticidal toxin (Cry toxin stemmed from Bacillus thuringiensis) target several lepidopteran and coleopteran pests...
  68. ncbi Risk assessment and ecological effects of transgenic Bacillus thuringiensis crops on non-target organisms
    Hui Lin Yu
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
    J Integr Plant Biol 53:520-38. 2011
    ..Crops expressing Cry toxins derived from Bacillus thuringiensis (Bt) have been planted worldwide, and are an effective tool for pest control...
  69. ncbi A novel Bacillus thuringiensis (PS149B1) containing a Cry34Ab1/Cry35Ab1 binary toxin specific for the western corn rootworm Diabrotica virgifera virgifera LeConte forms ion channels in lipid membranes
    Luke Masson
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada H4P 2R2
    Biochemistry 43:12349-57. 2004
    The binary Bacillus thuringiensis PS149B1 insecticidal crystal (Cry) protein is comprised of two components, Cry34Ab1, a 14-kDa protein, and Cry35Ab1, a 44-kDa protein, the combination of which forms a novel binary toxin active on western ..
  70. ncbi Bacteriocin-like inhibitor substances produced by Mexican strains of Bacillus thuringiensis
    J Eleazar Barboza-Corona
    Departamento de Ingeniería en Alimentos, Instituto de Ciencias Agricolas, Universidad de Guanajuato, Apartado postal 311, Irapuato, Guanajuato 36500, Mexico
    Arch Microbiol 187:117-26. 2007
    ..we report the production of bacteriocin-like inhibitor substances (Bt-BLIS) by five Mexican strains of Bacillus thuringiensis. Bacillus thuringiensis subsp. morrisoni (LBIT 269), B. thuringiensis subsp. kurstaki (LBIT 287), B...
  71. ncbi Mapping the epitope in cadherin-like receptors involved in Bacillus thuringiensis Cry1A toxin interaction using phage display
    I Gomez
    Instituto de Biotecnologia, Departamento de Microbiologia Molecular, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    J Biol Chem 276:28906-12. 2001
    ..lepidopteran insects, aminopeptidase N and cadherin-like proteins are the putative receptors for Bacillus thuringiensis (Bt) toxins...
  72. ncbi Interaction of the Bacillus thuringiensis delta endotoxins Cry1Ac and Cry3Aa with the gut of the pea aphid, Acyrthosiphon pisum (Harris)
    Huarong Li
    Department of Entomology, Iowa State University, 418 Science II Hall, Ames, IA 50011 3222, USA
    J Invertebr Pathol 107:69-78. 2011
    ..are not particularly susceptible to the effects of insecticidal Cry toxins derived from the bacterium Bacillus thuringiensis. We examined the physiological basis for the relatively low toxicity of Cry1Ac and Cry3Aa against the pea ..
  73. pmc Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile
    Mary C Rea
    Biotechnology Department, Teagasc, Moorepark Food Research Centre, Fermoy, Ireland
    Proc Natl Acad Sci U S A 107:9352-7. 2010
    ..difficile in the nanomolar range. Thuricin CD is produced by Bacillus thuringiensis DPC 6431, a bacterial strain isolated from a human fecal sample, and it consists of two distinct peptides, ..
  74. ncbi Effects of gossypol on fitness costs associated with resistance to Bt cotton in pink bollworm
    Yves Carriere
    Department of Entomology, The University of Arizona, Tucson, AZ 85716, USA
    J Econ Entomol 97:1710-8. 2004
    Fitness costs associated with insect resistance to Bacillus thuringiensis (Bt) crops may help to delay or prevent the spread of resistance alleles, especially when refuges of non-Bt host plants are present...
  75. pmc Expressed sequence tags from larval gut of the European corn borer (Ostrinia nubilalis): exploring candidate genes potentially involved in Bacillus thuringiensis toxicity and resistance
    Chitvan Khajuria
    Department of Entomology, 123 Waters Hall, Kansas State University, Manhattan, KS 66506, USA
    BMC Genomics 10:286. 2009
    ..the insect gut are crucial for understanding basic physiology of food digestion, their interactions with Bacillus thuringiensis (Bt) toxins, and for discovering new targets for novel toxins for use in pest management...
  76. ncbi Prevalence and diversity of insertion sequences in the genome of Bacillus thuringiensis YBT-1520 and comparison with other Bacillus cereus group members
    Ning Qiu
    State Key Laboratory of Agricultural Microbiology and National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, Hubei, China
    FEMS Microbiol Lett 310:9-16. 2010
    ..Sequencing of Bacillus thuringiensis ssp...
  77. pmc Complete genome sequence of Bacillus thuringiensis mutant strain BMB171
    Jin He
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, People s Republic of China
    J Bacteriol 192:4074-5. 2010
    b>Bacillus thuringiensis has been widely used as a biopesticide for a long time. Here we report the finished and annotated genome sequence of B...
  78. pmc 3'-5' tRNAHis guanylyltransferase in bacteria
    Ilka U Heinemann
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    FEBS Lett 584:3567-72. 2010
    ..We demonstrate in vitro Thg1 activity for recombinant enzymes from the two bacteria Bacillus thuringiensis and Myxococcus xanthus and provide a closer investigation of several archaeal Thg1...
  79. pmc Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin
    Ivan Arenas
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62250, Mexico
    J Biol Chem 285:12497-503. 2010
    Cry toxins produced by Bacillus thuringiensis have been recognized as pore-forming toxins whose primary action is to lyse midgut epithelial cells in their target insect...
  80. pmc Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm
    Shai Morin
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 100:5004-9. 2003
    ..of resistance by pests is the main threat to long-term insect control by transgenic crops that produce Bacillus thuringiensis (Bt) toxins...
  81. ncbi How Bacillus thuringiensis has evolved specific toxins to colonize the insect world
    R A de Maagd
    Plant Research International, PO Box 16, 6700 AA, Wageningen, The Netherlands
    Trends Genet 17:193-9. 2001
    b>Bacillus thuringiensis is a bacterium of great agronomic and scientific interest...
  82. ncbi Signaling versus punching hole: How do Bacillus thuringiensis toxins kill insect midgut cells?
    M Soberon
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    Cell Mol Life Sci 66:1337-49. 2009
    Cry proteins, produced by Bacillus thuringiensis (Bt), are widely used for the control of insect pests in agriculture as spray products or expressed in transgenic crops, such as maize and cotton...
  83. ncbi Evaluation of the natural refuge function for Helicoverpa arnigera (Lepidoptera: Noctuidae) within Bacillus thuringiensis transgenic cotton growing areas in north China
    Kongming Wu
    Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, PR China
    J Econ Entomol 95:832-7. 2002
    The density of Helicoverpa armigera (Hübner) populations on Bacillus thuringiensis Berliner (Bt) transgenic cotton, corn, peanut, and soybean; differences in its development on Bt cotton and common (nontransgenic) cotton; and the ..
  84. ncbi Identification of novel Bacillus thuringiensis Cry1Ac binding proteins in Manduca sexta midgut through proteomic analysis
    Rebecca J McNall
    Department of Biochemistry and Molecular Biology, University of Georgia, 413 Biological Sciences Building, 120 Cedar Street, Athens, GA 30602, USA
    Insect Biochem Mol Biol 33:999-1010. 2003
    The crystal proteins of Bacillus thuringiensis are widely used in transgenic crops and commercially available insecticides. Manduca sexta, the tobacco hornworm, is the model insect for B. thuringiensis studies...
  85. pmc Parasporal body formation via overexpression of the Cry10Aa toxin of Bacillus thuringiensis subsp. israelensis, and Cry10Aa-Cyt1Aa synergism
    Alejandro Hernández-Soto
    Centro de Investigacion en Biologia Celular y Molecular, Ciudad de la Investigación, Universidad de Costa Rica, San Jose, Costa Rica
    Appl Environ Microbiol 75:4661-7. 2009
    b>Bacillus thuringiensis subsp. israelensis is the most widely used microbial control agent against mosquitoes and blackflies...
  86. ncbi Mode of action of mosquitocidal Bacillus thuringiensis toxins
    Mario Soberon
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca 62250, Morelos, Mexico
    Toxicon 49:597-600. 2007
    Cry toxins from Bacillus thuringiensis (Bt) are used for insect control. Their primary action is to lyse midgut epithelial cells...
  87. ncbi Suppression of exposure to malaria vectors by an order of magnitude using microbial larvicides in rural Kenya
    Ulrike Fillinger
    School of Biological and Biomedical Sciences, Durham University, Durham, UK
    Trop Med Int Health 11:1629-42. 2006
    ..To determine the contribution larviciding could make to reduce the burden of malaria, by conducting a trial of microbial larvicides in a 4.5 km2 area in and around a large village in rural western Kenya...
  88. pmc A critical assessment of the effects of Bt transgenic plants on parasitoids
    Mao Chen
    Department of Entomology, Cornell University New York State Agricultural Experiment Station NYSAES, Geneva, New York, United States of America
    PLoS ONE 3:e2284. 2008
    ..safety of transgenic insecticidal plants expressing crystal proteins (Cry toxins) from the bacterium Bacillus thuringiensis (Bt) continues to be debated...
  89. pmc Host plant and population determine the fitness costs of resistance to Bacillus thuringiensis
    Ben Raymond
    Division of Biology, Faculty of Natural Sciences, Imperial College London, Silwood Park Campus, Ascot, Berks SL5 7PY, UK
    Biol Lett 3:82-5. 2007
    ..investigated whether reduced plant quality would increase the fitness costs associated with resistance to Bacillus thuringiensis in two populations of the diamondback moth Plutella xylostella...
  90. pmc Microbial larvicide application by a large-scale, community-based program reduces malaria infection prevalence in urban Dar es Salaam, Tanzania
    Yvonne Geissbuhler
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS ONE 4:e5107. 2009
    ..Elimination of malaria transmission from urban areas may require larval control strategies that complement adult mosquito control using insecticide-treated nets or houses, particularly where vectors feed outdoors...
  91. ncbi Midgut GPI-anchored proteins with alkaline phosphatase activity from the cotton boll weevil (Anthonomus grandis) are putative receptors for the Cry1B protein of Bacillus thuringiensis
    Erica Soares Martins
    Universidade de Brasilia, Departamento de Biologia Celular, Brasilia, DF, Brazil
    Insect Biochem Mol Biol 40:138-45. 2010
    Cry toxins from Bacillus thuringiensis (Bt) are used for insect control...
  92. ncbi Isolation and sequence of a 2-kbp miniplasmid from Bacillus thuringiensis var. kurstaki HD-3a3b: relationship with miniplasmids of other B. thuringiensis strains
    R Marin
    Departement de Biochimie, faculte des sciences et genie, Universite Laval, Sainte Foy, Quebec, Canada
    FEMS Microbiol Lett 73:263-9. 1992
    The miniplasmid profiles of 18 Bacillus thuringiensis strains belonging to 8 different serotypes were determined using an alkaline hydrolysis method for isolation of low molecular mass plasmids...
  93. pmc Anopheles gambiae cadherin AgCad1 binds the Cry4Ba toxin of Bacillus thuringiensis israelensis and a fragment of AgCad1 synergizes toxicity
    Gang Hua
    Department of Entomology, University of Georgia, Athens, Georgia 30602 2603, USA
    Biochemistry 47:5101-10. 2008
    ..from Anopheles gambiae larvae and analyzed for its possible role as a receptor for the Cry4Ba toxin of Bacillus thuringiensis strain israelensis...
  94. ncbi Distribution of phenotypes among Bacillus thuringiensis strains
    Phyllis A W Martin
    USDA ARS Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, MD 20705, USA
    Syst Appl Microbiol 33:204-8. 2010
    An extensive collection of Bacillus thuringiensis isolates from around the world were phenotypically profiled using standard biochemical tests...
  95. ncbi Characterization of a novel Cry9Bb delta-endotoxin from Bacillus thuringiensis
    J O Silva-Werneck
    Embrapa Recursos Genéticos e Biotecnologia Parque Estação Biológica, Final W5 Norte, Brasilia, DF 70 770 900, Brazil
    J Invertebr Pathol 98:320-8. 2008
    The Brazilian Bacillus thuringiensis serovar japonensis strain S725 was selected for its toxicity to the velvetbean caterpillar, Anticarsia gemmatalis...
  96. ncbi Functional display of Bacillus thuringiensis Cry1Ac toxin on T7 phage
    Sabino Pacheco
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos
    J Invertebr Pathol 92:45-9. 2006
    The Cry1Ac toxin from Bacillus thuringiensis was displayed on the surface of T7 phage...
  97. pmc Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis
    Cliff S Han
    Department of Energy Joint Genome Institute, Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    J Bacteriol 188:3382-90. 2006
    Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis are closely related gram-positive, spore-forming bacteria of the B. cereus sensu lato group. While independently derived strains of B...
  98. ncbi Structural implication of the induced immune response by Bacillus thuringiensis Cry proteins: role of the N-terminal region
    Gloria Guillermina Guerrero
    FES Iztacala, Universidad Nacional Autonoma de Mexico, Biomedicine Av de los Barrios s n Col Los Reyes Iztacala 54090 Tlanepantla, Edo de Mexico, Mexico
    Mol Immunol 41:1177-83. 2004
    ..These data indicate that immunogenic abilities of the Bt Cry proteins reside and depends of the N-terminal half...
  99. ncbi Sequence variation in trypsin- and chymotrypsin-like cDNAs from the midgut of Ostrinia nubilalis: methods for allelic differentiation of candidate Bacillus thuringiensis resistance genes
    B S Coates
    USDA ARS, Corn Insects and Crop Genetics Research Unit, Iowa State University, Ames, IA 50010, USA
    Insect Mol Biol 15:13-24. 2006
    Midgut expressed alkaline serine proteases of Lepidoptera function in conversion of Bacillus thuringiensis (Bt) protoxin to active toxin, and reduced level of transcript T23 is associated with Ostrinia nubilalis resistance to Dipel Bt ..
  100. ncbi Purification and characterization of a chimeric Cry1F delta-endotoxin expressed in transgenic cotton plants
    Yong Gao
    Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA
    J Agric Food Chem 54:829-35. 2006
    Cotton plants were genetically modified through the introduction of a synthetic gene that encodes a Bacillus thuringiensis insecticidal protoxin referred to as Cry1F(synpro)...
  101. pmc Chemical modulators of the innate immune response alter gypsy moth larval susceptibility to Bacillus thuringiensis
    Nichole A Broderick
    Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA
    BMC Microbiol 10:129. 2010
    ..For example, ingestion of Bacillus thuringiensis by larvae of some species of susceptible Lepidoptera can result in normally benign enteric bacteria ..

Research Grants39

  1. Activation of PI Specific Phospholipase C Enzymes
    MARY FEDARKO ROBERTS; Fiscal Year: 2013
    ..Although the three proteins we study, Bacillus thuringiensis PI-PLC, Listeria monocytogenes PI-PLC, and mammalian PLC41, share a common structural framework for the ..
  2. B. thuringiensis Crystal Proteins as Powerful Next-Generation Anthelmintics
    Raffi V Aroian; Fiscal Year: 2013
    ..New anti-roundworm drugs are urgently needed. We have pioneered the development of Bacillus thuringiensis (Bt) Cry proteins that kill roundworms...
  3. DNA segregation during Bacillus growth and development
    JOSEPH A POGLIANO; Fiscal Year: 2013
    ..From studying plasmid pBtoxis in Bacillus thuringiensis, we identified a novel segregation protein belonging to the tubulin superfamily...
  4. Mosquito Vector Control Using Bt Coupled to Seed Oil Bodies
    Mohd Amir Abdullah; Fiscal Year: 2009
    ..Research Phase I project develops a more efficient and environmentally safe method to produce and deliver Bacillus thuringiensis israelensis (Bti) toxins and BtBoosters (BtB) for mosquito control...
  5. Molecular Improvement of Bacterial Mosquito Larvicides
    Brian A Federici; Fiscal Year: 2013
    ..to continue our basic studies that have already enabled us to develop recombinant bacteria based on Bacillus thuringiensis subsp...
  6. Mosquitocidal Action of Bacillus thuringensis Toxins
    Sarjeet S Gill; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacillus thuringiensis subsp. israelensis (Bti) has been used in the field for over twenty years without resistance development in any target insect. In contrast, mosquito resistance to B...
  7. Mosquitocidal Avtive Clostridium Toxins
    Sarjeet Gill; Fiscal Year: 2007
    ..For example, Bacillus thuringiensis subsp...
  8. Plasmid pXO2 Replication in Bacillus anthracis
    Saleem Khan; Fiscal Year: 2005
    ..anthracis and closely related species such as Bacillus cereus, Bacillus thuringiensis and Bacillus mycoides, making it likely that the pXO1 and pXO2 plasmids could naturally transfer from B...
  9. Structural studies of Bacillus thuringiensis Cry Toxins
    Michael K Chan; Fiscal Year: 2010
    The Bacillus thuringiensis Cry proteins are novel bacterial toxins with practical application as biological insecticides for the targeting of specific crop pests (caterpillars, beetles, nematodes) and disease vectors (mosquitoes)...
  10. MOLECULAR MODE OF ACTION OF BACILLUS THURINGIENSIS TOXIN
    MICHAEL WOLFERSBERGER; Fiscal Year: 1992
    The mechanism of insecticidal action of Bacillus thuringiensis delta-endotoxin on lepidopteran larvae involves specific binding between the toxin and one or more proteins of the brush border membrane of midgut columnar cells...
  11. PHOSPHOLIPASES AND THE PATHOGENESIS OF LISTERIA
    Howard Goldfine; Fiscal Year: 1993
    ..the newly defined gene, designated plcA, with sequences in a database revealed extensive homology with the Bacillus thuringiensis phosphatidylinositol-specific phospholipase C(PI-PLC). The investigator(s) have subsequently shown that L...
  12. PROTEIN STRUCTURE/FUNCTION RELATIONSHIPS
    LEE BULLA; Fiscal Year: 1993
    ..faculty members are: (i) characterization of a mosquito protein that specifically binds the toxin of Bacillus thuringiensis subsp...
  13. Highly Improved Bacterial Larvicides for Vector Control
    Brian Federici; Fiscal Year: 2007
    ..These bacteria will be significantly more cost-effective than Bacillus thuringiensis subsp, israelensis (Bti) and Bacillus sphaericus (Bs), the active ingredients of current commercial ..
  14. EXPRESSION OF THE CYTA TOXIN OF BTI IN A CYANOBACTERIUM
    Scott Franklin; Fiscal Year: 2000
    ..The use of mosquitocidal toxins produced by Bacillus thuringiensis subsp...
  15. LABORATORY BIOCONTROL EVALUATIONS AGAINST SIMULIIDAE
    MARSHALL LAIRD; Fiscal Year: 1980
    ..Commercial formulations of Bacillus thuringiensis var. israelensis will be laboratory and field tested against simuliids and non-target organisms...
  16. Host Factors Regulating Bt Cry5B Toxicity in C elegans
    LARRY BISCHOF; Fiscal Year: 2006
    b>Bacillus thuringiensis (Bt) pore-forming crystal proteins (Cry) are toxic towards insects and nematodes. The nematode C. elegans provides an excellent model to study the mechanism of Cry protein toxicity. In addition, C...
  17. REGULATION OF RNA SYNTHESIS
    Douglas Bradley; Fiscal Year: 1992
    The genes coding for the crystal proteins synthesized by Bacillus thuringiensis are notable because they are expressed at extraordinarily high levels but only during sporulation and the gene products are insecticidal...
  18. Assembly Visualized Routine Flourescence Microscopy
    Philip Serwer; Fiscal Year: 2008
    ..Applications are anticipated in the analysis of the assembly of disease-causing viruses and determining pathways of oncogenesis. ..
  19. Enhanced Capillary DNA Sequencing
    Philip Serwer; Fiscal Year: 2004
    ..Each adaptation will help solve a current genomic problem, for example, either closing of a partially assembled genome sequence or performing high accuracy analysis of mutations. ..
  20. DNA Packaging Motors
    Philip Serwer; Fiscal Year: 2005
    ..Analysis of bacteriophage DNA packaging motors is expected to provide a basis for understanding the role of motors in disease, especially disease caused by a virus that has a DNA packaging motor. ..
  21. Population genetics of transgenes in mosquito vectors
    Fred Gould; Fiscal Year: 2008
    ..A user-friendly form of the models as well as an accessible manual will be developed and placed on the internet. ..
  22. Plant Production and Delivery System for Bacterial Toxins to Mosquity Larvae
    Mohd Amir Abdullah; Fiscal Year: 2008
    ..Some forms of bacterial toxins from Bacillus thuringiensis subspecies israelensis (Bti toxin) have strong dipteran activity, and are specific for mosquito and ..
  23. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  24. Glutathione-s-transferase mediated pyrethroid resistance in Culex pipiens s.l.
    Anthony Cornel; Fiscal Year: 2007
    ..These studies will also lead to understanding the mechanism of metabolic resistance to aid in development of novel, next generation insecticides and synergists that may augment pyrethroids. [unreadable] [unreadable] [unreadable]..
  25. Cloning and Engineering of Nicking enzymes
    Shuang yong Xu; Fiscal Year: 2004
    ..abstract_text> ..
  26. Polytene chromosomes of Culex pipiens mosquito complex
    Anthony Cornel; Fiscal Year: 2004
    ..p. pipiens, Cx. p. quinquefasciatus and Cx. p. molestus and 2) Determine chromosomal homologies between Cx. p. pipiens, Cx. p. quinquefasciatus and Cx. p. molestus. ..
  27. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  28. A universal DNA endonuclease
    Shuang yong Xu; Fiscal Year: 2005
    ..For isothermal applications of the universal nuclease at 50oC-70oC, the nuclease domain will be derived from thermophilic endonucleases. ..
  29. ASSEMBLY OF THE SPORE COAT OF B SUBTILIS
    Adam Driks; Fiscal Year: 2005
    ..Studies of coat assembly may reveal novel approaches to combat these disease-causing agents. ..
  30. STRATEGIES FOR INACTIVATING BACILLUS ANTHRACIS SPORES
    Arthur Aronson; Fiscal Year: 2003
    ..Once such reagents or methods have been identified, they will be tested on spores in various soils that should mimic natural environments and thus the conditions needed for the effective control of this bioweapon. ..
  31. Microfluidics, Physics and Chemistry of Gordon Conference
    LAURIE LOCASCIO; Fiscal Year: 2005
    ....
  32. A Genetic System Able to Screen for Active DNA Demethylation
    Shuang yong Xu; Fiscal Year: 2006
    ..In addition, knowledge of the mechanism of demethylation could be crucial in converting fully differentiated adult stem cells into totipotent stem cells. [unreadable] [unreadable] [unreadable]..
  33. Engineering DNA nicking endonucleases
    Shuang yong Xu; Fiscal Year: 2006
    ..Under Phase II funding, this isothermal amplification method (NEMDA) will be optimized and the sensitivity will be improved. Finally, we will investigate the potential of NEMDA for detections of pathogens and its use in bio-prospecting. ..
  34. Functional Domains of Bacillus thuringiensis Endotoxins
    DONALD DEAN; Fiscal Year: 2007
    DESCRIPTION (provided by the applicant): Bacillus thuringiensis is a microbial insecticide that is widely used to control insects, including mosquitoes and black flies...
  35. IDENTIFICATION OF B. ANTRACIS SPORE-SURFACE PROTEINS
    Adam Driks; Fiscal Year: 2003
    ..subtilis coats ongoing in our laboratory, as well as the available genome sequences of the two organisms. Ultimately, this work will enable development of a new class of small, robust versatile B. anthracis spore detectors. ..