theileria parva

Summary

Summary: A protozoan parasite that is the etiologic agent of East Coast fever (THEILERIASIS). Transmission is by ticks of the Physicephalus and Hyalomma genera.

Top Publications

  1. ncbi Laboratory and field investigations into the Theileria parva carrier-state in cattle in Zimbabwe
    A A Latif
    Midrand University, Faculty of Science, Halfway House, South Africa
    Onderstepoort J Vet Res 68:203-8. 2001
  2. ncbi The persistence of Theileria parva infection in cattle immunized using two stocks which differ in their ability to induce a carrier state: analysis using a novel blood spot PCR assay
    R A Skilton
    International Livestock Research Institute, Nairobi, Kenya
    Parasitology 124:265-76. 2002
  3. ncbi Reverse line blotting: a new technique for the sensitive detection of tick borne pathogens
    A Tait
    Department of Veterinary Parasitology, Institute of Comparative Medicine, University of Glasgow, Bearsden Rd, Glasgow G61 1QH, UK
    Arch Inst Pasteur Tunis 81:47-50. 2004
  4. ncbi A comparison of seroprevalence and risk factors for Theileria parva and T. mutans in smallholder dairy cattle in the Tanga and Iringa regions of Tanzania
    Emmanuel S Swai
    Veterinary Investigation Centre VIC, Box 1068, Arusha, Tanzania
    Vet J 174:390-6. 2007
  5. ncbi Occurrence of Theileria parva infection in cattle on a farm in the Ladysmith district, KwaZulu-Natal, South Africa
    B E Thompson
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa
    J S Afr Vet Assoc 79:31-5. 2008
  6. ncbi Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes
    Brian Shiels
    Division of Veterinary Infection and Immunity, Parasitology Group, Institute of Comparative Medicine, Faculty of Veterinary Medicine, Bearsden Rd, Glasgow G61 1QH, UK
    Int J Parasitol 36:9-21. 2006
  7. ncbi Molecular and immunological characterisation of Theileria parva stocks which are components of the 'Muguga cocktail' used for vaccination against East Coast fever in cattle
    R Bishop
    International Livestock Research Institute ILRI, P O Box 30709, Nairobi, Kenya
    Vet Parasitol 94:227-37. 2001
  8. pmc Construction of a genetic map for Theileria parva: identification of hotspots of recombination
    Frank Katzer
    Moredun Research Institute, Pentlands Science Park, Penicuik, Midlothian, UK
    Int J Parasitol 41:669-75. 2011
  9. ncbi Cell invasion by Theileria sporozoites
    Michael K Shaw
    G452 Stopford Building, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, UK, M13 9PT
    Trends Parasitol 19:2-6. 2003
  10. pmc Genotypic diversity, a survival strategy for the apicomplexan parasite Theileria parva
    F Katzer
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    Vet Parasitol 167:236-43. 2010

Research Grants

Detail Information

Publications165 found, 100 shown here

  1. ncbi Laboratory and field investigations into the Theileria parva carrier-state in cattle in Zimbabwe
    A A Latif
    Midrand University, Faculty of Science, Halfway House, South Africa
    Onderstepoort J Vet Res 68:203-8. 2001
    The Theileria parva carrier-state in cattle on commercial farms on Zimbabwe was investigated using parasitological and serological methods...
  2. ncbi The persistence of Theileria parva infection in cattle immunized using two stocks which differ in their ability to induce a carrier state: analysis using a novel blood spot PCR assay
    R A Skilton
    International Livestock Research Institute, Nairobi, Kenya
    Parasitology 124:265-76. 2002
    An improved Theileria parva DNA detection assay based on the polymerase chain reaction (PCR) using primers derived from the 104 kDa antigen (p104) gene was developed to detect parasite DNA in blood spots on filter paper...
  3. ncbi Reverse line blotting: a new technique for the sensitive detection of tick borne pathogens
    A Tait
    Department of Veterinary Parasitology, Institute of Comparative Medicine, University of Glasgow, Bearsden Rd, Glasgow G61 1QH, UK
    Arch Inst Pasteur Tunis 81:47-50. 2004
    ..The sensitivity and the specificity are discussed in relation to the use of this technique in the Maghreb..
  4. ncbi A comparison of seroprevalence and risk factors for Theileria parva and T. mutans in smallholder dairy cattle in the Tanga and Iringa regions of Tanzania
    Emmanuel S Swai
    Veterinary Investigation Centre VIC, Box 1068, Arusha, Tanzania
    Vet J 174:390-6. 2007
    ..dairying areas of Tanzania to determine the distribution and prevalence and to quantify risk factors for Theileria parva and T. mutans during the period January to April 1999...
  5. ncbi Occurrence of Theileria parva infection in cattle on a farm in the Ladysmith district, KwaZulu-Natal, South Africa
    B E Thompson
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa
    J S Afr Vet Assoc 79:31-5. 2008
    b>Theileria parva causes widespread morbidity and mortality in cattle in endemic regions. An outbreak of theileriosis occurred on a farm near Ladysmith in KwaZulu-Natal, South Africa, which is not a declared Corridor disease-infected area...
  6. ncbi Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes
    Brian Shiels
    Division of Veterinary Infection and Immunity, Parasitology Group, Institute of Comparative Medicine, Faculty of Veterinary Medicine, Bearsden Rd, Glasgow G61 1QH, UK
    Int J Parasitol 36:9-21. 2006
    The apicomplexan parasites Theileria annulata and Theileria parva cause severe lymphoproliferative disorders in cattle...
  7. ncbi Molecular and immunological characterisation of Theileria parva stocks which are components of the 'Muguga cocktail' used for vaccination against East Coast fever in cattle
    R Bishop
    International Livestock Research Institute ILRI, P O Box 30709, Nairobi, Kenya
    Vet Parasitol 94:227-37. 2001
    The 'Muguga cocktail' which is composed of three Theileria parva stocks Muguga, Kiambu 5 and Serengeti-transformed has been used extensively for live vaccination against East Coast fever in cattle in eastern, central and southern Africa...
  8. pmc Construction of a genetic map for Theileria parva: identification of hotspots of recombination
    Frank Katzer
    Moredun Research Institute, Pentlands Science Park, Penicuik, Midlothian, UK
    Int J Parasitol 41:669-75. 2011
    The tick-borne protozoan parasite Theileria parva is the causal agent of East Coast Fever (ECF), a severe lymphoproliferative disease of cattle in eastern, central and southern Africa. The life cycle of T...
  9. ncbi Cell invasion by Theileria sporozoites
    Michael K Shaw
    G452 Stopford Building, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, UK, M13 9PT
    Trends Parasitol 19:2-6. 2003
  10. pmc Genotypic diversity, a survival strategy for the apicomplexan parasite Theileria parva
    F Katzer
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    Vet Parasitol 167:236-43. 2010
    The tick-borne protozoan parasite Theileria parva causes East Coast fever (ECF), a severe lymphoproliferative disease of cattle that is a major constraint to the improvement of livestock in eastern, central and southern Africa...
  11. ncbi Theileria parva ribosomal internal transcribed spacer sequences exhibit extensive polymorphism and mosaic evolution: application to the characterization of parasites from cattle and buffalo
    N E Collins
    Onderstepoort Veterinary Institute, Pretoria, South Africa
    Parasitology 118:541-51. 1999
    We sequenced the rRNA genes and internal transcribed spacers (ITS) of several Theileria parva isolates in an attempt to distinguish between the causative agents of East coast fever and Corridor disease...
  12. ncbi A Babesia bovis gene syntenic to Theileria parva p67 is expressed in blood and tick stage parasites
    Jeanne M Freeman
    USDA ARS, Knipling Bushland U S Livestock Insects Research Laboratory, 2700 Fredericksburg Rd Kerrville, TX 78028, USA
    Vet Parasitol 173:211-8. 2010
    ..Comparative genomics of the hemoprotozoan parasites B. bovis and Theileria parva revealed a highly conserved syntenic block of genes flanking the p67 gene of T...
  13. ncbi Estimating seroprevalence and variation to four tick-borne infections and determination of associated risk factors in cattle under traditional mixed farming system in Mbeere District, Kenya
    J M Gachohi
    International Livestock Research Institute ILRI, Old Naivasha Rd, Kabete, P O Box 30709 00100, Nairobi, Kenya
    Prev Vet Med 95:208-23. 2010
    A cross-sectional study of serum antibody responses of cattle to tick-borne disease (TBD) parasites (Theileria parva, Theileria mutans, Anaplasma marginale and Babesia bigemina) was conducted on traditional smallholder mixed farms in ..
  14. pmc Expression analysis of the Theileria parva subtelomere-encoded variable secreted protein gene family
    Jacqueline Schmuckli-Maurer
    Molecular Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    PLoS ONE 4:e4839. 2009
    The intracellular protozoan parasite Theileria parva transforms bovine lymphocytes inducing uncontrolled proliferation...
  15. ncbi Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
    Malcolm J Gardner
    Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:134-7. 2005
    We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa...
  16. ncbi Genome of the host-cell transforming parasite Theileria annulata compared with T. parva
    Arnab Pain
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 309:131-3. 2005
    ....
  17. pmc Properties of non-coding DNA and identification of putative cis-regulatory elements in Theileria parva
    Xiang Guo
    The Institute for Genomic Research J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
    BMC Genomics 9:582. 2008
    ..In this study, we analyze the evolution of non-coding sequences in the Theileria genome and identify conserved sequence elements that may be involved in gene regulation of these parasitic species...
  18. ncbi Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)
    R A Skilton
    International Livestock Research Institute ILRI, Nairobi, Kenya
    Parasitology 117:321-30. 1998
    To identify the genes encoding novel immunodominant antigens of Theileria parva a lambda gt11 library of piroplasm genomic DNA was immunoscreened with bovine recovery serum and a gene encoding a 150 kDa antigen (p150) was identified...
  19. ncbi Using the transcriptome to annotate the genome revisited: application of massively parallel signature sequencing (MPSS)
    Trushar Shah
    International Livestock Research Institute, PO Box 30709, Nairobi, Kenya
    Gene 366:104-8. 2006
    ..reproducible transcription, in multiple MPSS cycles, from 73% of computationally predicted genes in the Theileria parva schizont lifecycle stage. Signatures spanning consecutive exons confirmed 142 predicted introns...
  20. ncbi Acquisition and transmission of Theileria parva by vector tick, Rhipicephalus appendiculatus
    Satoru Konnai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Acta Trop 99:34-41. 2006
    In order to investigate the transmission dynamics of Theileria parva (T. parva) by the brown ear tick, Rhipicephalus appendiculatus (R. appendiculatus), under experimental conditions, detection of T...
  21. ncbi Enzymes of glucose and glycerol catabolism in in vitro-propagated Theileria parva schizonts
    T N Kiama
    Department of Biochemistry, University of Nairobi, Nairobi, Kenya
    Vet J 158:221-7. 1999
    b>Theileria parva schizonts propagated in vitro in peripheral blood lymphocytes were purified and assayed for key enzymes of glucose and glycerol catabolism and the citric acid cycle...
  22. ncbi Development and evaluation of a real-time polymerase chain reaction test for the detection of Theileria parva infections in Cape buffalo (Syncerus caffer) and cattle
    Kgomotso P Sibeko
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    Vet Parasitol 155:37-48. 2008
    Corridor disease, caused by the tick-borne protozoan parasite Theileria parva, is a controlled disease in South Africa...
  23. ncbi MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes
    Kyoko Hayashida
    Division of Collaboration and Education, Hokkaido University, Research Center for Zoonosis Control, Sapporo 001 0020, Japan
    Exp Mol Pathol 94:228-38. 2013
    ..b>Theileria parva (T...
  24. ncbi Theileria parva: taking control of host cell proliferation and survival mechanisms
    D A Dobbelaere
    Institute of Animal Pathology, Molecular Pathology, Berne, Switzerland
    Cell Microbiol 2:91-9. 2000
    The intracellular parasite Theileria parva infects and transforms bovine T-cells, inducing their uncontrolled proliferation and spread in non-lymphoid as well as lymphoid tissues...
  25. pmc Live immunisation against Theileria parva: containing or spreading the disease?
    Declan J McKeever
    Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK
    Trends Parasitol 23:565-8. 2007
    Although a live vaccine against Theileria parva has been available for over 30 years, concerns that vaccine strains can become established in resident tick populations have impeded its uptake in endemic areas. Recently, Oura et al...
  26. ncbi In vivo comparison of susceptibility between Bos indicus and Bos taurus cattle types to Theileria parva infection
    S G Ndungu
    Kenya Agricultural Research Institute, National Veterinary Research Centre, P O Box 32, Kikuyu, Kenya
    Onderstepoort J Vet Res 72:13-22. 2005
    ..Bos taurus cattle differ form Bos indicus in their susceptibility to infection with the Muguga stabilate of Theileria parva and in their resistance to the resultant disease. Ten Friesians (B. taurus), ten improved Borans (B...
  27. pmc Concerted evolution at a multicopy locus in the protozoan parasite Theileria parva: extreme divergence of potential protein-coding sequences
    R Bishop
    International Livestock Research Institute ILRI, Nairobi, Kenya
    Mol Cell Biol 17:1666-73. 1997
    ..of tandemly arrayed open reading frames (ORFs) containing several repeated elements has been described for Theileria parva. Herein we show that probes derived from the 5'/N-terminal ends of ORFs in the genomic DNAs of T...
  28. ncbi A nested PCR assay exhibits enhanced sensitivity for detection of Theileria parva infections in bovine blood samples from carrier animals
    David O Odongo
    The International Livestock Research Institute, P O Box 30709, Nairobi, Kenya
    Parasitol Res 106:357-65. 2010
    b>Theileria parva causes East Coast fever, an economically important disease of cattle in sub-Saharan Africa. We describe a nested polymerase chain reaction (nPCR) assay for the detection of T...
  29. ncbi Escape from CD8+ T cell response by natural variants of an immunodominant epitope from Theileria parva is predominantly due to loss of TCR recognition
    Timothy K Connelley
    The Roslin Institute and The Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, Scotland, United Kingdom
    J Immunol 187:5910-20. 2011
    ..chain (TRB) diversity of the CD8(+) T cell responses of cattle against two immunodominant epitopes from Theileria parva (Tp1(214-224) and Tp2(49-59)) and investigated the role of TCR recognition and MHC binding in determining ..
  30. pmc Characterisation of gp34, a GPI-anchored protein expressed by schizonts of Theileria parva and T. annulata
    Gondga Xue
    Division of Molecular Pathobiology, DCR VPH, Vetsuisse Faculty, University of Bern, CH 3013 Bern, Switzerland
    Mol Biochem Parasitol 172:113-20. 2010
    ..Overexpression of Tp-gp34 and Ta-gp34 induced cytokinetic defects and resulted in accumulation of binucleated cells. These findings suggest that gp34 could contribute to important parasite-host interactions during host cell division...
  31. ncbi Organisation and informational content of the Theileria parva genome
    V Nene
    International Livestock Research Institute, Nairobi, Kenya
    Mol Biochem Parasitol 95:1-8. 1998
    When compared with other Apicomplexan organisms, Theileria parva has an exceptionally small, 10-12 Mbp, genome...
  32. pmc Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva
    P Toye
    International Laboratory for Research on Animal Diseases, Nairobi, Kenya
    Infect Immun 64:1832-8. 1996
    The polymorphic immunodominant molecule (PIM) of Theileria parva is expressed by the schizont and sporozoite stages of the parasite...
  33. ncbi History and critical review of Theileria parva (Boleni), the vaccine stock against Zimbabwean cattle theileriosis
    Abdalla A Latif
    ARC Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort 0110, South Africa
    Ticks Tick Borne Dis 2:163-7. 2011
    ..reviews the infectivity, cross-immunization experiments, and cattle vaccination of Zimbabwean cattle-derived Theileria parva (Boleni) sporozoite stabilates produced at the Central Veterinary Laboratory (CVL) in Harare between 1980 and ..
  34. pmc Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
    Roger Pelle
    International Livestock Research Institute, Nairobi, Kenya
    PLoS ONE 6:e19015. 2011
    b>Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer)...
  35. ncbi Epidemiological studies on tick-borne diseases of cattle in Central Equatoria State, Southern Sudan
    D A Salih
    Central Veterinary Research Laboratories, Al Amarat, PO Box 8067, Khartoum, Sudan
    Parasitol Res 101:1035-44. 2007
    ..5%). Using reverse line blot, it was possible to detect and differentiate eight different piroplasms namely, Theileria parva (71.2%), Theileria mutans (73%), Theileria velifera (45.3%), Theileria taurotragi (2...
  36. ncbi A panel of microsatellite and minisatellite markers for the characterisation of field isolates of Theileria parva
    C A L Oura
    Department of Microbiology and Parasitology, Veterinary Faculty, University of Makerere, P O Box 7062, Kampala, Uganda
    Int J Parasitol 33:1641-53. 2003
    ..of a panel of 11 polymorphic microsatellites and 49 polymorphic minisatellites of the protozoan haemoparasite Theileria parva. The PCR products were run on high resolution Spreadex gels on which the alleles were identified and sized...
  37. ncbi A Theileria parva type 1 protein phosphatase activity
    X Cayla
    Laboratoire de Physiologie de la Reproduction, INRA CNRS ESA 7080, 9 quai Saint Bernard, 75005, Paris, France
    Mol Biochem Parasitol 110:161-6. 2000
    ..Intriguingly, since type 1 OA-sensitive phosphatase activity has been recently described in Plasmodium falciparum, we can conclude that these medically important parasites produce their one PP1...
  38. ncbi Clinical features associated with seroconversion to Anaplasma marginale, Babesia bigemina and Theileria parva infections in African cattle under natural tick challenge
    J W Magona
    National Livestock Resources Research Institute NaLIRRI, P O Box 96, Tororo, Uganda
    Vet Parasitol 155:273-80. 2008
    ..identifying clinical features for prediction of seroconversion to Anaplasma marginale, Babesia bigemina and Theileria parva infections...
  39. ncbi The incidence, calf morbidity and mortality due to Theileria parva infections in smallholder dairy farms in Murang'a District, Kenya
    G K Gitau
    International Livestock Research Institute, Nairobi, Kenya
    Prev Vet Med 39:65-79. 1999
    ..study was conducted among smallholder dairy farmers in Murang'a District, Kenya, to estimate the incidence of Theileria parva infections, as well as calf morbidity and mortality caused by the infection...
  40. ncbi Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity
    Ekta H Patel
    International Livestock Research Institute, P O Box 30709 00100, Nairobi, Kenya
    Vet Parasitol 179:62-8. 2011
    ..Infection and Treatment Method of vaccination against East Coast fever comprises an inoculation of live Theileria parva sporozoites and simultaneous administration of oxytetracycline...
  41. ncbi An outbreak of East Coast Fever on the Comoros: a consequence of the import of immunised cattle from Tanzania?
    R De Deken
    Institute of Tropical Medicine Antwerp, Nationalestraat 155, B 2000 Antwerp, Belgium
    Vet Parasitol 143:245-53. 2007
    ..Fatalities started soon after the import of cattle from Tanzania. Theileria parva and its vector, Rhipicephalus appendiculatus, could be identified as the main culprits of the epidemic...
  42. ncbi Transformation of leukocytes by Theileria parva and T. annulata
    D Dobbelaere
    Department of Molecular Pathology, University of Berne, Switzerland
    Annu Rev Microbiol 53:1-42. 1999
    b>Theileria parva and T. annulata provide intriguing models for the study of parasite-host interactions. Both parasites possess the unique property of being able to transform the cells they infect; T...
  43. ncbi Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
    Lavoisier Akoolo
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 121:216-21. 2008
    East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite...
  44. ncbi Population genetic analysis and sub-structuring of Theileria parva in Uganda
    C A L Oura
    Department of Microbiology and Parasitology, Faculty of Vet Medecine, University of Makerere, P O Box 7062, Kampala, Uganda
    Mol Biochem Parasitol 140:229-39. 2005
    ..We have undertaken a population genetic analysis of another apicomplexan species (Theileria parva) to investigate the levels of diversity of this parasite and the role of genetic exchange in three ..
  45. ncbi Distinct CD4+ T cell helper requirements in Theileria parva-immune and -naive bovine CTL precursors
    E L Taracha
    International Livestock Research Institute, Nairobi, Kenya
    J Immunol 159:4539-45. 1997
    ..evidence that class I MHC-restricted parasite-specific CD8+ CTL protect cattle against the protozoan parasite Theileria parva. As part of an effort to develop a subunit vaccine for the induction of these responses, we have investigated ..
  46. ncbi The biological and practical significance of antigenic variability in protective T cell responses against Theileria parva
    W I Morrison
    Division of Veterinary Clinical Sciences, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK
    Vet Parasitol 148:21-30. 2007
    ..One such parasite is Theileria parva which induces potent CD8 T cell responses that play an important role in immunity...
  47. ncbi Baculovirus surface display of Theileria parva p67 antigen preserves the conformation of sporozoite-neutralizing epitopes
    Stephen A Kaba
    Laboratory of Virology, Wageningen University, Binnenhaven 11, 6709 PD Wageningen, The Netherlands
    Protein Eng 16:73-8. 2003
    b>Theileria parva is an intracellular protozoan parasite that causes East Coast fever, a severe lymphoproliferative disease in cattle...
  48. ncbi Bovine immunity - a driver for diversity in Theileria parasites?
    Declan J McKeever
    Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
    Trends Parasitol 25:269-76. 2009
    b>Theileria parva and Theileria annulata are tick-borne parasites of cattle that infect and transform leukocytes, causing severe and often fatal parasitic leukoses. Both species provoke strong immunity against subsequent infection...
  49. ncbi The kinetics of Theileria parva infection and lymphocyte transformation in vitro
    Mara S L Rocchi
    Clinical Division, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Scotland, UK
    Int J Parasitol 36:771-8. 2006
    ..Rather, specific cell types appear to undergo selection very early after infection and expansion of particular cell subsets results in survival and growth of only a small proportion of the cells originally parasitized...
  50. ncbi Linkage disequilibrium between alleles at highly polymorphic mini- and micro-satellite loci of Theileria parva isolated from cattle in three regions of Kenya
    D O Odongo
    International Livestock Research Institute, P O Box 30709, Nairobi 00100, Kenya
    Int J Parasitol 36:937-46. 2006
    b>Theileria parva schizont-infected lymphocyte culture isolates from western, central and coastal Kenya were analysed for size polymorphism at 30 T...
  51. pmc Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
    Simon P Graham
    International Livestock Research Institute, Nairobi, Kenya
    Proc Natl Acad Sci U S A 103:3286-91. 2006
    East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle...
  52. ncbi Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis
    Peter Küenzi
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, Bern, Switzerland
    J Immunol 171:1224-31. 2003
    ..Bovine T cells transformed by the intracellular parasite Theileria parva proliferate in an uncontrolled manner and undergo clonal expansion...
  53. ncbi Immunization against diseases caused by Theileria parva: a review
    G Uilenberg
    A Surgente, Cargèse, Corsica, France
    Trop Med Int Health 4:A12-20. 1999
    b>Theileria parva is the causative agent of three epidemiologically different diseases, East Coast fever (ECF), Corridor disease and January disease, caused by 3 types of T. parva, T. p. parva, T. p. lawrencei and T. p. bovis, respectively...
  54. ncbi Characterisation of NF-kappa B complexes in Theileria parva-transformedT cells
    J Machado
    Laboratory of Molecular Pathology, Institute of Animal Pathology, University of Berne, Langgass strasse 122, 3012, Berne, Switzerland
    Microbes Infect 2:1311-20. 2000
    Transformation of T cells by the intracellular parasite Theileria parva is accompanied by constitutive I-kappa B degradation and NF-kappa B activation, a process which is essential to prevent the spontaneous apoptosis of these parasite-..
  55. pmc CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity
    Niall D MacHugh
    The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, UK
    Eur J Immunol 39:2459-69. 2009
    ..In previous studies we have observed that CD8(+) T-cell responses to Theileria parva exhibit different patterns of parasite strain specificity in cattle of different MHC genotypes...
  56. ncbi Loop-mediated isothermal amplification (LAMP) assays for detection of Theileria parva infections targeting the PIM and p150 genes
    Oriel M M Thekisoe
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Int J Parasitol 40:55-61. 2010
    We have developed two loop-mediated isothermal amplification (LAMP) assays for the detection of Theileria parva, the causative agent of East Coast fever (ECF), an economically important cattle disease in eastern, central and southern ..
  57. pmc Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parva
    Simon P Graham
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Infect Immun 76:685-94. 2008
    Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated by CD8 T cells. Six antigens targeted by CD8 T cells from T...
  58. ncbi Four p67 alleles identified in South African Theileria parva field samples
    Kgomotso P Sibeko
    Department of Veterinary Tropical Diseases, University of Pretoria, Onderstepoort 0110, South Africa
    Vet Parasitol 167:244-54. 2010
    Previous studies characterizing the Theileria parva p67 gene in East Africa revealed two alleles...
  59. ncbi Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
    Simon P Graham
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 115:383-9. 2007
    ..Immunisation of cattle with a recombinant form of the polymorphic immunodominant molecule from Theileria parva emulsified with immunostimulatory CpG oligodeoxynucleotides in adjuvant had no effect on the induction of ..
  60. ncbi Genes transcribed in the salivary glands of female Rhipicephalus appendiculatus ticks infected with Theileria parva
    Vishvanath Nene
    Parasite Genomics Department, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Insect Biochem Mol Biol 34:1117-28. 2004
    ..derived from an uninfected tick cDNA library and 9844 ESTs were from a cDNA library from ticks infected with Theileria parva, which develop in type III salivary gland acini...
  61. ncbi Highly syntenic and yet divergent: a tale of two Theilerias
    William Weir
    Institute of Comparative Medicine, Glasgow University Veterinary School, Glasgow, UK
    Infect Genet Evol 9:453-61. 2009
    ..Species-specific expansion and diversification at this critical locus is discussed with reference to the availability, in the near future, of genomic datasets which are based on non-transforming Theileria species...
  62. ncbi Use of micro-rotation imaging to study JNK-mediated cell survival in Theileria parva-infected B-lymphocytes
    R Lizundia
    Laboratoire du Signalisation Immunoparasitaire, URA CNRS 2851, Department Parasitologie, Institut Pasteur, Paris, France
    Parasitology 130:629-35. 2005
    Lymphocytes infected with the protozoan parasite Theileria parva are transformed to permanently proliferating cells, an event underlying the pathology of the disease...
  63. pmc Extensive genotypic diversity in a recombining population of the apicomplexan parasite Theileria parva
    Frank Katzer
    Division of Veterinary Clinical Sciences, Royal Dick School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, United Kingdom
    Infect Immun 74:5456-64. 2006
    We evaluated sexual recombination in the apicomplexan parasite Theileria parva using genome-wide marker analysis of haploid sporozoite populations obtained from infected Rhipicephalus appendiculatus ticks...
  64. ncbi An unusual mosaic structure of the PIM gene of Theileria parva and its relationship to allelic diversity
    Dirk Geysen
    Department of Animal Health, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    Mol Biochem Parasitol 133:163-73. 2004
    ..and structural organisation of the polymorphic immunodominant molecule (PIM) gene of the protozoan parasite Theileria parva was studied in isolates from sympatric and allopatric areas...
  65. ncbi Epidemiological studies on Theileriosis and the dynamics of Theileria parva infections in Rwanda
    T Bazarusanga
    National Veterinary Laboratory of Rwanda, BP 804 Kigali, Rwanda
    Vet Parasitol 143:214-21. 2007
    ..collected during the 2002 dry season and the 2003 wet season were further analysed using the p104 Theileria parva specific PCR. The results from the 18S characterisation showed the presence of four Theileria spp., namely T...
  66. pmc Influence of host immunity on parasite diversity in Theileria parva
    Frank Katzer
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, United Kingdom
    Infect Immun 75:4909-16. 2007
    ..the influence of host immunity on the genotypic diversity of the intracellular transforming cattle parasite Theileria parva. By tracking the emergence of discrete parasite genotypes in an animal challenged with a bulk stabilate ..
  67. pmc Theileria parva and the bovine CTL response: down but not out?
    D J McKeever
    Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    Parasite Immunol 28:339-45. 2006
    b>Theileria parva is a tick-borne intracellular protozoan of cattle, with obligate sequential differentiation stages in lymphocytes and erythrocytes...
  68. pmc Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage
    Richard Bishop
    The International Livestock Research Institute ILRI, PO Box 30709, Nairobi, Kenya
    Nucleic Acids Res 33:5503-11. 2005
    ..parallel signature sequencing (MPSS) was used to analyze the transcriptome of the intracellular protozoan Theileria parva. In total 1,095,000, 20 bp sequences representing 4371 different signatures were generated from T...
  69. ncbi Progress towards understanding the immunobiology of Theileria parasites
    W Ivan Morrison
    The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, UK
    Parasitology 136:1415-26. 2009
    The pathogenic Theileria species Theileria parva and T. annulata infect bovine leukocytes and erythrocytes causing acute, often fatal lymphoproliferative diseases in cattle...
  70. ncbi Current status of vaccine development against Theileria parasites
    W I Morrison
    Division of Veterinary Clinical Sciences, Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, UK
    Parasitology 133:S169-87. 2006
    The tick-borne protozoan parasites Theileria parva and Theileria annulata cause economically important diseases of cattle in tropical and sub-tropical regions...
  71. ncbi Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM
    Carlo L Casanova
    Molecular Pathology, Vetsuisse Faculty, University of Bern, CH 3012 Bern, Switzerland
    Mol Biochem Parasitol 149:144-54. 2006
    The presence of the schizont stage of the obligate intracellular parasites Theileria parva or T. annulata in the cytoplasm of an infected leukocyte results in host cell transformation via a mechanism that has not yet been elucidated...
  72. ncbi Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field
    C A L Oura
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Woking GU24ONF, Surrey
    Parasitology 134:1205-13. 2007
    ..widely deployed in Eastern, Central and Southern Africa to protect cattle against East Coast fever, caused by Theileria parva. The vaccine contains 3 component stocks (Muguga, Serengeti-transformed and Kiambu 5)...
  73. pmc A rapid and sensitive intracellular flow cytometric assay to identify Theileria parva infection within target cells
    M S Rocchi
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland
    Parasitology 135:195-201. 2008
    b>Theileria parva is an intracellular protozoan parasite transmitted by ticks that causes a fatal lymphoproliferative disease of cattle known as East Coast Fever...
  74. ncbi The persistence of component Theileria parva stocks in cattle immunized with the 'Muguga cocktail' live vaccine against East Coast fever in Uganda
    C A L Oura
    Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, Makerere University, P O Box 7062, Kampala, Uganda
    Parasitology 129:27-42. 2004
    The 'Muguga cocktail' live vaccine comprises three Theileria parva stocks (Muguga, Kiambu 5 and the buffalo-derived Serengeti-transformed) and has been used extensively in Eastern, Central and Southern Africa with an infection and ..
  75. ncbi A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappaB activation of Theileria parva-transformed B cells
    Julien Guergnon
    Laboratoire de Signalisation Immunoparasitaire, URA CNRS 1960, Departement de Parasitologie, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cell Microbiol 5:709-16. 2003
    ..Interestingly, both pharmacological inhibition of TNF synthesis and neutralizing anti-TNF antibodies lead to a reduction in proliferation and a 50% drop in NF-kappaB activation, without inducing apoptosis...
  76. ncbi Characterization of a polymorphic Theileria annulata surface protein (TaSP) closely related to PIM of Theileria parva: implications for use in diagnostic tests and subunit vaccines
    Leonhard Schnittger
    Forschungszentrum Borstel, Parkallee 22, 23845 Borstel, Germany
    Mol Biochem Parasitol 120:247-56. 2002
    ..High identity of the N- and C-terminal regions with the polymorphic immunodominant molecule (PIM) of Theileria parva (identity of 93%), the existence of a central polymorphic region and two short introns within genomic clones ..
  77. ncbi Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres
    R Bishop
    International Livestock Research Institute ILRI, Nairobi, Kenya
    Mol Biochem Parasitol 110:359-71. 2000
    ..b>Theileria parva telomere-associated (TA) DNA from two chromosomes contained long open reading frames (ORFs) 54% identical at ..
  78. ncbi Dissection of the clonal composition of bovine alphabeta T cell responses using T cell receptor Vbeta subfamily-specific PCR and heteroduplex analysis
    T Connelley
    Division of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, UK
    J Immunol Methods 335:28-40. 2008
    ..of parasite-reactive CD8(+) T cells obtained from two animals immunised with the protozoan parasite Theileria parva. Analyses of uncloned T cell lines as well as large panels of cloned T cells derived from each of these lines ..
  79. ncbi Genetic fingerprinting of Theileria parva using a telomeric DNA probe
    R P Bishop
    International Livestock Research Institute ILRI, Nairobi, Kenya
    Parasitol Res 82:264-6. 1996
    A cloned Theileria parva telomeric DNA sequence, designated pTpUtel, was used to characterize T. parva stocks and clones by hybridization to EcoRI-digested DNA. Eight of the nine T...
  80. ncbi A membrane-anchored Theileria parva cyclophilin with a non-cleaved amino-terminal signal peptide for entry into the endoplasmic reticulum
    Thomas Ebel
    Institute for Vascular Biology and Thrombosis Research, University of Vienna, Brunner Str 59, A1235 Vienna, Austria
    Vet Parasitol 121:65-77. 2004
    ..sequence of a cDNA encoding a cyclophilin family member of the intracellular protozoan parasite of cattle Theileria parva contains a conserved C-terminal domain that exhibits 70% amino acid identity to cyclophilin proteins from ..
  81. ncbi Protective immune mechanisms against Theileria parva: evolution of vaccine development strategies
    D J McKeever
    International Livestock Research Institute, PO Box 30709, Nairobi, Kenya
    Parasitol Today 15:263-7. 1999
    b>Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa...
  82. ncbi Theileria parva epidemics: a case study in eastern Zambia
    M Billiouw
    Department of Animal Health, Institute of Tropical Medicine, Antwerpen, Belgium
    Vet Parasitol 107:51-63. 2002
    ..It is demonstrated that an efficient immunisation campaign should concentrate its efforts in the period of low adult R. appendiculatus abundance (July-October)...
  83. ncbi Theileria parva genomics reveals an atypical apicomplexan genome
    V Nene
    International Livestock Research Institute, P O Box 30709, Nairobi, Kenya
    Int J Parasitol 30:465-74. 2000
    ..We propose to determine the genome sequence of Theileria parva, a pathogen of cattle, using the random shotgun approach pioneered at The Institute for Genomic Research (..
  84. ncbi Buffalo-associated Theileria parva: the risk to cattle of buffalo translocation into the Highveld of Zimbabwe
    A A Latif
    Faculty of Science, Midrand University, P O Box 2986, Halfway House 1685, South Africa
    Ann N Y Acad Sci 969:275-9. 2002
    ..b>Theileria parva (Boleni), the vaccine used to immunize cattle against theileriosis, and a buffalo-derived T...
  85. ncbi Theileria parva infection in calves causes massive lymphocyte death in the thymus, spleen and lymph nodes without initial proliferation
    G K Mbassa
    Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P O Box 3016, Morogoro, Tanzania
    Vet Parasitol 142:260-70. 2006
    ..or apoptosis eleven 3-month-old healthy calves were experimentally infected with the protozoan parasite Theileria parva, which is reported to cause lymphocyte proliferation. Four control calves were not infected...
  86. ncbi Factors influencing the distribution of questing ticks and the prevalence estimation of T. parva infection in brown ear ticks in the Tanga region, Tanzania
    E S Swai
    Veterinary Investigation Centre, P O Box 1068, Arusha, Tanzania
    J Vector Ecol 31:224-8. 2006
    ..006 for Amani and cool to dry season, respectively). Based on the polymerase chain reaction technique, Theileria parva infection prevalence in adult R. appendiculatus was estimated to be 2.6%...
  87. pmc Cloned Theileria parva produces lesser infections in ticks compared to uncloned T. parva despite similar infections in cattle
    A R Walker
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin EH25 9RG, Scotland, UK
    Onderstepoort J Vet Res 73:157-62. 2006
    Experimental transmissions of cloned Theileria parva in cattle with Rhipicephalus appendiculatus ticks were compared to transmissions with uncloned T...
  88. ncbi Perception of cattle farmers of the efficacy of east coast fever immunization in southern Zambia
    P Fandamu
    Department of Veterinary and Livestock Development, Mazabuka Veterinary Research Station, Mazabuka, Zambia
    Trop Anim Health Prod 38:9-16. 2006
    ..These findings provide valuable information on how livestock farmers perceive and adopt new animal disease control strategies and the information could be useful in their planning and implementation...
  89. ncbi Cytokines inhibit the development of trophozoite-infected cells of Theileria annulata and Theileria parva but enhance the proliferation of macroschizont-infected cell lines
    P M Preston
    Division of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Scotland, UK
    Parasite Immunol 14:125-41. 1992
    ..inhibited the in vitro development of trophozoite-infected cells of three stocks of Theileria annulata and of Theileria parva (Muguga). However, none of these cytokines inhibited the proliferation of established T. annulata or T...
  90. ncbi Determination of potential risk factors associated with Theileria annulata and Theileria parva infections of cattle in the Sudan
    D A Salih
    Division of Veterinary Infection Biology and Immunology, Research Center Borstel, Parkallee 22, 23845, Borstel, Germany
    Parasitol Res 101:1285-8. 2007
    ..analysis was performed on two sets of data on the prevalence of Theileria annulata in Northern Sudan and Theileria parva in Southern Sudan, to determine the potential risk factors that might affect the distribution of the ..
  91. ncbi Immunization of cattle against East Coast fever using Theileria parva (Marikebuni) and relaxation of tick control in North Rift, Kenya
    J M Wanjohi
    Kenya Agricultural Research Institute, National Veterinary Research Centre Muguga, Kikuyu
    Onderstepoort J Vet Res 68:217-23. 2001
    A total of 90 animals was immunized against East Coast fever (ECF) using Theileria parva (Marikebuni) stock on three large-scale farms in Kiminini Division, Trans-Nzoia District, North Rift, Kenya...
  92. ncbi Orientation of bovine CTL responses towards PIM, an antibody-inducing surface molecule of Theileria parva, by DNA subunit immunization
    Cedric Ververken
    Laboratory of Livestock Physiology, Immunology and Genetics, Department of Biosystems, Faculty of Bioscience Engineering, K U Leuven, Kasteelpark Arenberg 30, 3001 Leuven, Belgium
    Vet Immunol Immunopathol 124:253-63. 2008
    East Coast fever, an acute lymphoproliferative disease of cattle, is caused by the apicomplexan parasite Theileria parva. Protective immunity is mediated by CD8(+) cytotoxic T lymphocytes directed against schizont-infected cells...
  93. ncbi Live immunisation against Theileria parva: spreading the disease?
    Dirk Geysen
    Trends Parasitol 24:245-6. 2008
  94. ncbi Transmission of Theileria parva in the traditional farming sector in the Southern Province of Zambia during 1997-1998
    M Mulumba
    ASVEZA South, Veterinary Research Station, Mazabuka, Zambia
    Trop Anim Health Prod 33:117-25. 2001
    The incidence of first contact with the protozoan Theileria parva was determined in two traditional cattle herds in the Southern Province of Zambia during a period of average rainfall in 1997 and 1998, following a drought in the previous ..
  95. ncbi Epidemiological observations of Zimbabwean theileriosis: disease incidence and pathogenicity in susceptible cattle during Rhipicephalus appendiculatus nymphal and adult seasonal activity
    A A Latif
    Faculty of Science, Midrand University, Halfway House, South Africa
    Onderstepoort J Vet Res 68:187-95. 2001
    ..to tick-borne diseases were used as tracer animals to assess the tick challenge and pathogenicity of Theileria parva under field conditions in Zimbabwe...
  96. ncbi Comparison of the survival on ice of thawed Theileria parva sporozoites of different stocks cryoprotected by glycerol or sucrose
    V Mbao
    Department of Animal Health, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    Onderstepoort J Vet Res 74:9-15. 2007
    Stabilates of Theileria parva sporozoites are mostly delivered in liquid nitrogen tanks to the East Coast fever immunization points...
  97. ncbi Attenuated vaccines for tropical theileriosis, babesiosis and heartwater: the continuing necessity
    Varda Shkap
    Division of Parasitology, Kimron Veterinary Institute, Bet Dagan, Israel
    Trends Parasitol 23:420-6. 2007
    ..As a result, there is a continuing necessity to use available live vaccines in tick and tick-borne disease-control strategies adapted to conditions prevailing in many parts of the world...
  98. ncbi Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites
    Richard Bishop
    International Livestock Research Institute, PO Box 30709, Nairobi, Kenya
    Vaccine 21:1205-12. 2003
    Full-length recombinant versions of p67, the 709 amino acid major surface protein of Theileria parva sporozoites, induce immunity to East Coast fever (ECF) in cattle...
  99. ncbi Spatial and management factors associated with exposure of smallholder dairy cattle in Tanzania to tick-borne pathogens
    E S Swai
    Faculty of Veterinary Medicine, Sokoine University of Agriculture, Morogoro, Tanzania
    Int J Parasitol 35:1085-96. 2005
    A cross-sectional study of serum antibody responses of cattle to tick-borne pathogens (Theileria parva, Theileria mutans,Anaplasma marginale, Babesia bigemina and Babesia bovis) was conducted on smallholder dairy farms in Tanga and ..
  100. ncbi Theileria parva: in vitro studies on the effects of holding temperature, pH and medium on sporozoite infectivity
    E N Kimbita
    International Livestock Research Institute, Department of Veterinary Microbiology and Parasitology, Sokoine University of Agriculture, PO Box 3019, Morogoro, Tanzania
    Trop Anim Health Prod 36:341-51. 2004
    The effects of holding temperature, pH and medium on the infectivity of Theileria parva sporozoites were investigated using an in vitro infectivity assay...
  101. ncbi In vitro titration of Theileria parva tick derived stabilates
    T Marcotty
    Veterinary Department, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
    Parasitology 128:131-7. 2004
    Immunization against the protozoan Theileria parva by infection and treatment has proved to be very efficient for the control of East Coast fever, an acute and often-fatal lymphoproliferative tick-borne disease of cattle in Eastern, ..

Research Grants2

  1. EXTRACELLULAR DEVELOPMENT IN VITRO OF MALARIA PARASITES
    William Trager; Fiscal Year: 1991
    ..for serious congenital infection and recently of increased significance in AIDS patients, the cattle parasite Theileria parva, cause of East Coast fever and, most important, the malarial parasites...
  2. GENETIC DISSECTION OF TOXOPLASMA GONDII
    David Roos; Fiscal Year: 2008
    ..In addition to their value for the analysis of folate metabolism and drug resistance, these tools should be broadly applicable to other studies on the biology and biochemistry of Toxoplasma. ..