Top Publications

  1. ncbi Interaction of Escherichia coli and macrophages: alteration by treatment of bacteria with beta-lactam antibiotics
    W Opferkuch
    Department of Medical Microbiology and Immunology,
    Zentralbl Bakteriol Mikrobiol Hyg A 266:116-26. 1987
  2. ncbi Nosocomial pansinusitis in orotracheally intubated critically ill patients
    H Spapen
    Department of Intensive Care, University Hospital, Vrije Universiteit Brussel, Belgium
    Acta Otorhinolaryngol Belg 49:251-5. 1995
  3. ncbi Specific spoilage organisms in breweries and laboratory media for their detection
    L Jespersen
    Royal Veterinary and Agricultural University, Department of Dairy and Food Science, Food Microbiology, Frederiksberg, Denmark
    Int J Food Microbiol 33:139-55. 1996
  4. ncbi HACEK group endocarditis at the Riyadh Armed Forces Hospital
    N el Khizzi
    Division of Microbiology, Armed Forces Hospital, Riyadh, KSA
    J Infect 34:69-74. 1997
  5. pmc Nasopharyngeal carriage of community-acquired, antibiotic-resistant Streptococcus pneumoniae in a Zambian paediatric population
    A Woolfson
    Department of Medicine, John Radcliffe Hospital, University of Oxford, England
    Bull World Health Organ 75:453-62. 1997
  6. ncbi [Studies on respiratory infections in primary care clinic (II). Distribution and antibiotic sensitivity to 45 agents of bacteria isolated from patients with respiratory infections visiting a doctor in private practice]
    A Watanabe
    Department of Internal Medicine, Research Institute for Chest Diseases and Cancer, Tohoku University
    Kansenshogaku Zasshi 64:66-75. 1990
  7. ncbi Melatonin in relation to cellular antioxidative defense mechanisms
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, USA
    Horm Metab Res 29:363-72. 1997
  8. ncbi 2,2,2-Trifluoroethanol-induced enteropathy in rats: chemically or bacterially mediated effects
    J C Kim
    Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201
    Toxicol Pathol 15:388-400. 1987
  9. ncbi [Detection of bactericidal antibody in the breast milk of a mother infected with enterohemorrhagic Escherichia coli O157:H7]
    E Adachi
    Department of Infectious Diseases Research, National Children's Medical Research Center
    Kansenshogaku Zasshi 73:451-6. 1999
  10. ncbi The role of phosphatidylglycerol as a functional effector and membrane anchor of the D1-core peptide from photosystem II-particles of the cyanobacterium Oscillatoria chalybea
    O Kruse
    , , , Bundesrepublik Deutschland
    Z Naturforsch C 50:380-90. 1995

Detail Information

Publications455 found, 100 shown here

  1. ncbi Interaction of Escherichia coli and macrophages: alteration by treatment of bacteria with beta-lactam antibiotics
    W Opferkuch
    Department of Medical Microbiology and Immunology,
    Zentralbl Bakteriol Mikrobiol Hyg A 266:116-26. 1987
    ..These changes of morphology lead to problems in the comparison of such bacterial forms with untreated organisms. Therefore, in this study outer membrane vesicles from bacteria were used as a model to investigate the effect ..
  2. ncbi Nosocomial pansinusitis in orotracheally intubated critically ill patients
    H Spapen
    Department of Intensive Care, University Hospital, Vrije Universiteit Brussel, Belgium
    Acta Otorhinolaryngol Belg 49:251-5. 1995
    ..2) aspiration of both maxillary sinuses yielded pus, cultures of which revealed a high concentration of micro organisms. Nosocomial pneumonia and bacteremia were considered related to the N P if the organisms found in the sinus were ..
  3. ncbi Specific spoilage organisms in breweries and laboratory media for their detection
    L Jespersen
    Royal Veterinary and Agricultural University, Department of Dairy and Food Science, Food Microbiology, Frederiksberg, Denmark
    Int J Food Microbiol 33:139-55. 1996
    The Gram positive bacteria are generally regarded as the most hazardous beer spoilage organisms in modern breweries, especially the lactobacilli: L. brevis, L. lindneri, L. curvatus, L. casei, L. buchneri, L. coryneformis, L...
  4. ncbi HACEK group endocarditis at the Riyadh Armed Forces Hospital
    N el Khizzi
    Division of Microbiology, Armed Forces Hospital, Riyadh, KSA
    J Infect 34:69-74. 1997
    INTRODUCTION: Fastidious Gram-negative organisms classified as the HACEK group (Haemophilus spp., Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens and Kingella spp...
  5. pmc Nasopharyngeal carriage of community-acquired, antibiotic-resistant Streptococcus pneumoniae in a Zambian paediatric population
    A Woolfson
    Department of Medicine, John Radcliffe Hospital, University of Oxford, England
    Bull World Health Organ 75:453-62. 1997
    ..Pneumococci were isolated from 71.9% of the children; the odds of carrying organisms were twice as high among children < 2 years of age compared with older children...
  6. ncbi [Studies on respiratory infections in primary care clinic (II). Distribution and antibiotic sensitivity to 45 agents of bacteria isolated from patients with respiratory infections visiting a doctor in private practice]
    A Watanabe
    Department of Internal Medicine, Research Institute for Chest Diseases and Cancer, Tohoku University
    Kansenshogaku Zasshi 64:66-75. 1990
    ..Staphylococcus aureus and other strains were documented simultaneously in 6 out of 7 cases in which multi-organisms were recovered. Many strains of Staphylococcus aureus were isolated from young patients throughout the year...
  7. ncbi Melatonin in relation to cellular antioxidative defense mechanisms
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, USA
    Horm Metab Res 29:363-72. 1997
    Melatonin's actions in organisms are more widespread than originally envisaged...
  8. ncbi 2,2,2-Trifluoroethanol-induced enteropathy in rats: chemically or bacterially mediated effects
    J C Kim
    Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201
    Toxicol Pathol 15:388-400. 1987
    ..Intestinal epithelial villi lost their cellular tissue integrity. Coccobacillary organisms were numerous in the ulcerated intestine. Hemolytic E...
  9. ncbi [Detection of bactericidal antibody in the breast milk of a mother infected with enterohemorrhagic Escherichia coli O157:H7]
    E Adachi
    Department of Infectious Diseases Research, National Children's Medical Research Center
    Kansenshogaku Zasshi 73:451-6. 1999
    ..As a result, breast milk samples (both colostrum and mature milk) from a patient were demonstrated to kill the organisms. One of 4 healthy milk samples, showed bactericidal activity though it was negative in O157-LPS antibody...
  10. ncbi The role of phosphatidylglycerol as a functional effector and membrane anchor of the D1-core peptide from photosystem II-particles of the cyanobacterium Oscillatoria chalybea
    O Kruse
    , , , Bundesrepublik Deutschland
    Z Naturforsch C 50:380-90. 1995
    ..spatial separation of the synthesis- and incorporation-site in the membrane, developed during evolution in eukaryotic organisms, might have changed the requirement on the mobility and the orientation of D1 in photosynthetic membranes.
  11. ncbi [Pathogenic bacteria isolated from the sputum of the patients with pulmonary emphysema]
    K Watanabe
    Second Department of Internal Medicine, School of Medicine, Fukuoka University
    Kansenshogaku Zasshi 69:1251-9. 1995
    ..influenza) were isolated. FEV1.0 had a similar tendency as VC in terms of isolated organisms from the patients with emphysema. Similarly, PO2 of the patients from whom MSSA or E...
  12. ncbi [Development of chromogenic agar medium for isolation of enterohaemorrhagic Escherichia coli O26]
    M Ikedo
    University of Tokyo
    Kansenshogaku Zasshi 75:291-9. 2001
    ..have been few studies for isolation of other serotypes of EHEC, and media appropriate for isolation of such organisms, especially from food samples, are not yet available. Among such serotypes, E...
  13. ncbi [Incidence of resistance and risk factors for resistance in Mycobacterium tuberculosis. A retrospective study of 1,055 patients of a specialty hospital 1984 to 1993]
    J Borchardt
    Krankenhaus Grosshansdorf,
    Pneumologie 50:28-35. 1996
    ..born in Germany, 32% of 101 patients with a history of prior antituberculosis drug therapy had resistant organisms, versus 4.2% of 698 patients without prior therapy (OR 10.7; 95% CI 6.1-18.7)...
  14. ncbi [Incidence of bacterial pneumonia in HIV-positive patients treated with preventive co-trimoxazole or pentamidine]
    A Koch
    Medizinische Klinik II,
    Pneumologie 52:614-21. 1998 the co-trimoxazole group and 13 in the pentamidine group (not significant); the most common causative organisms were S. pneumoniae (n = 4), S. aureus (n = 3) and H. influenzae (n = 3)...
  15. ncbi [Study on sepsis in the elderly at Nagoyashi-Koseiin Geriatric Hospital]
    T Yamamoto
    Department of Internal Medicine, Nagoyashi-Koseiin Geriatric Hospital
    Kansenshogaku Zasshi 69:1141-50. 1995
    ..8%), and prior antibiotic use (40.8%). All patients had an underlying disease. 2) Organisms isolated were Escherichia coli (21.2%), Staphylococcus aureus (18...
  16. ncbi [Septicemia associated with hematopoietic disorders and its features according to respective primary disorders]
    T Yokota
    Second Department of Internal Medicine, Osaka University Medical School
    Kansenshogaku Zasshi 70:108-15. 1996
    ..1% of ALL cases. Forty-seven point two percent of organisms which caused septicemia in ALL patients were isolated from surveillance cultures of the throat just before the ..
  17. ncbi Infection and immunity to Vibrio cholerae, Salmonella typhimurium and Escherichia coli in a rabbit model
    P A Guinee
    National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
    Zentralbl Bakteriol Mikrobiol Hyg A 270:260-9. 1988
    Cholera disease can be induced in the rabbit by duodenal inoculation (DI) of Vibrio cholerae organisms after ligation of the cecum (C) (DIC model). When ligation of the cecum is omitted, no disease symptoms develop...
  18. pmc O-Acetylserine sulfhydrylase from Methanosarcina thermophila
    B Borup
    Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA
    J Bacteriol 182:45-50. 2000
    Cysteine is the major source of fixed sulfur for the synthesis of sulfur-containing compounds in organisms of the Bacteria and Eucarya domains...
  19. ncbi [Neurologic manifestations of infectious endocarditis]
    N Hannachi
    , Tunis, Tunisie
    Arch Mal Coeur Vaiss 84:81-6. 1991
    ..The commonest organism was the staphylococcus (53% of identified organisms) but the number of negative blood cultures was high (50% of cases)...
  20. ncbi [Analysis of 98 cases of thoracic empyema]
    T Miyazaki
    Division of Infectious Diseases, Department of Internal Medicine, Juntendo University School of Medicine
    Kansenshogaku Zasshi 65:1583-92. 1991
    ..were most common. A single organism was isolated in pure culture from 39 cases. Single organisms isolated from fluids were more frequently aerobes (25) than anaerobes (14). The cases harboring Bacteroides spp...
  21. ncbi Detection of Mycobacterium tuberculosis in formaldehyde solution-fixed, paraffin-embedded tissue by polymerase chain reaction in Pott's disease
    R H Berk
    School of Medicine, Department of Orthopaedics and Traumatology, Dokuz Eylul University, Izmir, Turkey
    Spine (Phila Pa 1976) 21:1991-5. 1996
    ..Direct microscopy is insensitive because clinical samples may contain only few organisms. Recently, polymerase chain reaction has been applied in the rapid amplification and identification of many ..
  22. ncbi [Two cases of spotted fever group rickettsiosis contracted in southern parts of Africa]
    M Kimura
    Department of Infectious Diseases and Applied Immunology, University of Tokyo
    Kansenshogaku Zasshi 72:1311-6. 1998
    ..clinical features of the two rickettsiosis are reported to be separable, apparent cross reaction between the two organisms hampers the use of conventional antibody determinations for their differentiation...
  23. ncbi Effect of linear alkylbenzene sulfonate (LAS) on ion transport and intracellular calcium in kidney distal epithelial cells (A6)
    H F Bjerregaard
    Department of Life Sciences and Chemistry, Roskilde University, PO Box 260, 4000 Roskilde, Denmark
    Toxicol In Vitro 15:531-7. 2001
    ..from urban treatment plants in a concentration reported to have physiological and toxic effect on aquatic organisms. The aim of this study was to investigate the effect LAS on ion transport and homeostasis in epithelia cells...
  24. ncbi [Effects of various steroidal and non-steroidal anti-inflammatory drugs on in-vitro IL-10 production of murine peritoneal macrophages infected with Mycobacterium avium complex]
    T Shimizu
    Department of Microbiology and Immunology, Shimane Medical University
    Kansenshogaku Zasshi 71:910-7. 1997
    ..drugs (NSAID) on in-vitro IL-10 production of murine peritoneal macrophages (M phi s) infected with MAC organisms. When the IL-10 production by MAC-infected M phi s was measured in terms of protein and mRNA expression of the ..
  25. ncbi [The hygiene of refrigerated and frozen foods]
    H J Sinell
    Zentralbl Bakteriol Mikrobiol Hyg B 187:533-45. 1989
    ..Psychrotrophic organisms have particular significance as pathogens or spoilage organisms as they can multiply also during refrigeration; -..
  26. pmc Zygomycetes in human disease
    J A Ribes
    Departments of Pathology and Laboratory Medicine and of Clinical Laboratory Sciences, University of Kentucky, Lexington, KY 40536 0084, USA
    Clin Microbiol Rev 13:236-301. 2000
    ..There are two orders of Zygomycetes containing organisms that cause human disease, the Mucorales and the Entomophthorales...
  27. pmc Early post-splenectomy sepsis after missile injury in adults
    Y A Ellias
    Basrah Teaching Hospital, Iraq
    Ann R Coll Surg Engl 73:185-8. 1991
    ..This was significant (P < 0.005). Gram-negative coliforms were the most common organisms isolated comprising 72.5% and 67.8%, in contrast to pneumococci isolated in 5.9% and 3...
  28. ncbi [Clinical features of enterococcal septicemia and antimicrobial susceptibilities for clinical isolates of enterococci in Nagoya University Hospital]
    M Kadoya
    Department of Clinical Laboratory, Nagoya University Hospital
    Kansenshogaku Zasshi 65:1111-5. 1991
    Enterococci are important causative organisms of nosocomial infections as well as methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa...
  29. ncbi [Study on septicaemia in infants and children in the past 20 years. Part 1. An analysis of causal organisms]
    T Sato
    Department of Pediatrics, Kashiwa Hospital, Jikei University School of Medicine
    Kansenshogaku Zasshi 70:775-83. 1996
    Causal organisms and their changes were evaluated in 158 cases of septicaemia admitted to Jikei University Hospital from 1975 to 1994. Eighty patients (50.6%) were aged less than 1 year, and 37 patients (23.4%) were newborns...
  30. ncbi [Study on bacteremia due to community-acquired infection in infants and children without underlying diseases]
    H Sakata
    Department of Pediatrics, Asahikawa Kosei Hospital
    Kansenshogaku Zasshi 72:1197-201. 1998
    ..The causative organisms were Escherichia coli in 7, Haemophilus influenzae in 4, Streptococcus pneumoniae in 4, Staphylococcus aureus in ..
  31. ncbi Sexually transmittable organisms in the urethra of males with and without urethritis
    P Elsner
    Zentralbl Bakteriol Mikrobiol Hyg A 265:268-75. 1987
    ..The organisms were isolated in patients with and without urethritis as follows: N. gonorrhoeae with urethritis 19...
  32. pmc Diethylene glycol poisoning in Gurgaon, India, 1998
    J Singh
    National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi 110054, India
    Bull World Health Organ 79:88-95. 2001
    ..Samples of drinking-water and water from a tube-well were tested for coliform organisms. FINDINGS: Most of the children (26/36) were from the Gurgaon district in Haryana or had visited Gurgaon town ..
  33. ncbi [Forgotten episodes of the birth of cortisone]
    M Uchibayashi
    Takeda Science Foundation, Juso, Yodogawa-ku, Osaka
    Yakushigaku Zasshi 36:70-5. 2001
    ..of progesterone derived from diosgenin of the Mexican yam and a microbiological oxidation process developed by a chance discovery of suitable organisms. The former is attributed to R. E. Marker and the latter to D. H. Peterson.
  34. ncbi Common solvent toxicity: autoxidation of respiratory redox-cyclers enforced by membrane derangement
    T R Garbe
    Research Institute of Innovative Technology for the Earth, Kyoto, Japan
    Z Naturforsch C 56:483-91. 2001
    ..effects of chemically diverse solvents strikingly reveal the unifying motif of oxidant toxicity both in higher organisms and in aerobic bacteria...
  35. ncbi Bioregenerative [correction of bioregnerative] life support: not a picnic
    W M Knott
    National Aeronautics and Space Administration, Kennedy Space Center, FL, USA
    Gravit Space Biol Bull 11:31-9. 1998
    ..A solely bioregenerative life support system includes plants as a biomass production module and microbial organisms in bioreactors as a resource recovery module...
  36. ncbi Delayed infections after posterior TSRH spinal instrumentation for idiopathic scoliosis: revisited
    B R Richards
    Department of Orthopaedics, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA
    Spine (Phila Pa 1976) 26:1990-6. 2001
    ..presentation (infection) from index operation, clinical picture, sedimentation rate, presence of pseudarthrosis, organisms grown on culture, type of wound closure, and duration of antibiotics were examined...
  37. ncbi Do sterols reduce proton and sodium leaks through lipid bilayers?
    T H Haines
    Department of Chemistry, City College of the City University of New York and Biochemistry, City University of New York Medical School, New York, NY 10031, USA
    Prog Lipid Res 40:299-324. 2001
    ..Sodium gradients are used for animal plasma membranes, all other living organisms use proton gradients...
  38. ncbi [Legionella pneumophila serogroup 3 isolated from a patient of pneumonia developed after drowning in bathtub of a hot spring spa]
    R Shiota
    Department of Clinical Laboratory, Takinomiya General Hospital
    Kansenshogaku Zasshi 69:1356-64. 1995
    ..Patient recovered by erythromycin treatment and was discharged on the 59th hospital day. L. pneumophila SG3 organisms were again isolated from the spa water where the patient drawn...
  39. ncbi Interaction of quaternary ammonium and phosphonium salts with photosynthetic membranes
    S Spiegel
    , , , Germany
    Z Naturforsch C 56:1057-66. 2001
    ..We suggest a 3-step interaction of ABDAC with the thylakoid membranes of photosynthetic organisms similar to our earlier discussion (Bader and Höper (1993), Z. Naturforsch. 49c, 87-94)...
  40. ncbi The effects of amoxicillin therapy on skin flora in infants
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Dermatol 17:360-3. 2000
    ..and Propionibacterium acnes). Other organisms that were less often isolated were aerobic streptococci and Staphylococcus epidermidis...
  41. ncbi Microbiology of nonbullous impetigo
    I Brook
    Department of Pediatrics, Bethesda Naval Hospital, Maryland, USA
    Pediatr Dermatol 14:192-5. 1997
    ..fragilis and Peptostreptococcus spp. were isolated from one infection of the buttocks area. Thirty-three organisms isolated from 32 patients (80%) produced the enzyme beta-lactamase...
  42. ncbi Disseminated toxoplasmosis and acquired immunodeficiency syndrome: diagnosis by transmission electron microscopy
    J G Guccion
    Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    Ultrastruct Pathol 19:95-9. 1995
    ..biopsy performed on the day of his death revealed intracytoplasmic clusters of 3 microns long, oval, basophilic organisms, the exact nature of which was not evident by light microscopy...
  43. ncbi [Clinical significance of positive blood cultures in the Nagasaki Rosai Hospital during the past 6 years]
    H Masaki
    Department of Internal Medicine, Nagasaki Rosai Hospital
    Kansenshogaku Zasshi 68:617-24. 1994
    ..The distribution of bacteria showed increase percentage of the gram-positive organisms such as coagulase-negative Staphylococcus. Gram-negative organisms in included P. aeruginosa, A...
  44. ncbi Targeting and assembly of an oligomeric bacterial enterotoxoid in the endoplasmic reticulum of Saccharomyces cerevisiae
    O Schonberger
    Department of Molecular Biology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Mol Microbiol 5:2663-71. 1991
    ..Analyses of cell lysates from Saccharomyces cerevisiae and E. coli expressing the protein revealed that both organisms were able to assemble Lipo-EtxB into oligomers that were (i) stable in the presence of sodium dodecyl sulphate, (..
  45. ncbi [Bacteriological studies on pharyngeal and tracheal colonization in patients of operations and patients in ICU]
    Y Yoshitomi
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Kansenshogaku Zasshi 65:1569-77. 1991
    ..gram-negative rods such as Pseudomonas aeruginosa, and yeast liked organisms etc, which were resistant to antibiotics...
  46. ncbi Light-microscopical appearance and ultrastructure of Blastocystis hominis, an intestinal parasite of man
    Y Matsumoto
    Department of Medical Zoology, Kyoto Prefectural University of Medicine, Japan
    Zentralbl Bakteriol Mikrobiol Hyg A 264:379-85. 1987
    ..hominis in the lower ileum and cecum of a patient. When examined light-microscopically, organisms from stool materials, cultures, and aspirated intestinal lumen contents of a patient showed morphological ..
  47. ncbi Properties of aeromonads and their occurrence and hygienic significance in drinking water
    D van der Kooij
    , KIWA AG
    Zentralbl Bakteriol Mikrobiol Hyg B 187:1-17. 1988
    ..water of the municipal Dune Waterworks of The Hague and reports about the possible health significance of these organisms in drinking water. Literature data indicate that representatives of the motile Aeromonas species A...
  48. ncbi [A clinical study of bacteremia in urology]
    S Tokunaga
    Department of Urology, School of Medicine, Kanazawa University
    Kansenshogaku Zasshi 64:661-7. 1990
    ..However, Enterococcus spp. and Candida albicans were recognized as causative organisms of bacteremia via the urinary tract, because the urine culture demonstrated a species identical to that obtained ..
  49. ncbi [An epidemiological investigation for MRSA and PRSP in Kinki area. Kinki Infection Working Group]
    K Mikasa
    Second Department of Internal Medicine, Nara Medical University
    Kansenshogaku Zasshi 72:701-6. 1998
    ..Further, MRSA was accompanied by some other organisms (most frequently Pseudomonas aeruginosa) in 64.7% of MRSA positive patients...
  50. ncbi The phylogenetic position of red algae revealed by multiple nuclear genes from mitochondria-containing eukaryotes and an alternative hypothesis on the origin of plastids
    Hisayoshi Nozaki
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Mol Evol 56:485-97. 2003
    ..generally included very distant archaebacterial sequences (designated as the outgroup) and/or amitochondrial organisms, which may carry unusual gene substitutions due to parasitism or the absence of mitochondria...
  51. ncbi [Prognostic factors of prosthetic valve endocarditis. Apropos of 122 cases]
    S Witchitz
    , , Paris
    Arch Mal Coeur Vaiss 89:671-7. 1996
    ..The principal causative organisms were Staphylococcus aureus (33%), streptococci (20%), coagular-negative staphylococci (12%), enterococci (10%) ..
  52. ncbi Aerobic and anaerobic microbiology of necrotizing fasciitis in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, USA
    Pediatr Dermatol 13:281-4. 1996
    ..2). Organisms similar to the ones isolated from the NF aspirates were recovered in the blood of all patients except one...
  53. pmc Characteristics of a new cellulolytic Clostridium sp. isolated from pig intestinal tract
    V H Varel
    Roman L Hruska U S Meat Animal Research Center, Agricultural Research Service, Clay Center, Nebraska 68933
    Appl Environ Microbiol 58:1645-9. 1992
    ..The extent of degradation was equal to or better than that observed with the predominant ruminal cellulolytic organisms. On the basis of morphology, motility, spore formation, fermentation products, and the ability to hydrolyze ..
  54. pmc Bacteriuria in the elderly population in a developing country
    F A Orrett
    Department of Paraclinical Sciences, The University of West Indies, Faculty of Medical Sciences, Champs Fleurs, Trinidad and Tobago
    J Natl Med Assoc 93:238-42. 2001
    ..The overall prevalence of bacteriuria was 38.5%. More than 90% of the isolates were gram-negative organisms with Proteus species being the predominant pathogen among men, with 68.1% seen among inpatients...
  55. ncbi Light microscopic and ultrastructural evidence of in vivo phagocytosis of Helicobacter pylori by neutrophils
    Y Zu
    Department of Pathology, New York Veteran Affairs Medical Center, New York 10010, USA
    Ultrastruct Pathol 24:319-23. 2000
    ..pylori organisms. This study leaves open the question of whether, or how, neutrophils damage the gastric mucosa.
  56. ncbi [Study on azithromycin in treatment of diffuse panbronchiolitis]
    H Kobayashi
    First Department of Internal Medicine, Kyorin University School of Medicine
    Kansenshogaku Zasshi 69:711-22. 1995
    ..0 (6/21), cold agglutination reaction (22/28), and CRP (16/36) were also improved. The rate of eradication of organisms isolated from the sputum except for indigenous organisms was 39...
  57. ncbi [Trend of bacterial meningitis in children over a 14 year period (1981 through 1994) in Japan--an analysis based on studies in 27 institutions]
    Y Kobayashi
    Kobe City College of Nursing
    Kansenshogaku Zasshi 71:1017-24. 1997
    ..on dividing these years into 3 periods, 1981-1985, 1986-1990 and 1991-1994, and studied the trend of causative organisms identified in 254 among the 266 patients...
  58. ncbi [Surveys on the contamination of marine fish with non-O1 Vibrio cholerae and Vibrio mimicus and food poisoning cases by these organisms]
    H Kodama
    Toyama Institute of Health
    Kansenshogaku Zasshi 65:193-9. 1991
    ..variation and the concentration of contamination, and the actual cases of domestic food poisoning by these organisms. A 10 year survey revealed that non-O1 Vibrio cholerae (non-O1 V...
  59. ncbi Late-developing infection in instrumented idiopathic scoliosis
    C E Clark
    Division of Spinal Surgery, Miami Childrens Hospital, Florida, USA
    Spine (Phila Pa 1976) 24:1909-12. 1999
    ..Of those cultured for 7-10 days (the last 12) 11 were positive, usually for low-virulence skin organisms. After surgery, patients received antibiotics parenterally for 48 hours and orally for 7 days...
  60. ncbi An overview of topical antifungal therapy in dermatomycoses. A North American perspective
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center, Toronto, Ontario, Canada
    Drugs 55:645-74. 1998
    Dermatophytes cause fungal infections of keratinised tissues, e.g. skin, hair and nails. The organisms belong to 3 genera, Trichophyton, Epidermophyton and Microsporum...
  61. pmc Temperature-regulated protein synthesis by Leptospira interrogans
    J E Nally
    Department of Veterinary Medicine, University of Kentucky, Lexington, Kentucky 40546-0099, USA
    Infect Immun 69:400-4. 2001
    ..Increased synthesis of a 25-kDa outer membrane protein was observed when the organisms were shifted from 30 to 37 degrees C...
  62. ncbi [Studies on clinical significance of "Streptococcus milleri group" in respiratory infections]
    T Yamashiro
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 65:1419-29. 1991
    ..Though not included in the approved lists of bacterial names, "S. milleri group" are regarded as the causative organisms of suppurative infections, such as oral abscess, brain abscess, lung abscess and empyema...
  63. ncbi Trypanosoma cruzi: a putative vacuolar ATP synthase subunit and a CAAX prenyl protease-encoding gene, as examples of gene identification in genome projects
    B M Porcel
    Department of Genetics and Pathology, Section of Medical Genetics, Rudbeck Laboratory, Uppsala, SE 751 85, Sweden
    Exp Parasitol 95:176-86. 2000
    ..for further molecular characterization due to their similarity to genes with interesting functions in other organisms and their potential as targets to combat the parasite...
  64. ncbi The ancestry and cumulative evolution of immune reactions
    Jolanta M Dzik
    Nencki Institute of Experimental Biology, Department of Biochemistry, Warsaw University of Life Sciences, Warszawa, Poland
    Acta Biochim Pol 57:443-66. 2010
    ..Even unicellular organisms possess mechanisms for pathogen destruction and self recognition...
  65. ncbi Protective immunity against Vibrio cholerae infection in the rabbit
    P A Guinee
    National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands
    Zentralbl Bakteriol Mikrobiol Hyg A 266:552-62. 1987
    ..Duodenal inoculation (DI) without ligation of the cecum with live V. cholerae organisms did not cause any disease symptom but induced protection against subsequent challenges with homologous and ..
  66. pmc Secretory bulk flow of soluble proteins is efficient and COPII dependent
    B A Phillipson
    Centre for Plant Sciences, Leeds Institute for Plant Biotechnology and Agriculture, School of Biology, The University of Leeds, Leeds LS2 9JT, United Kingdom
    Plant Cell 13:2005-20. 2001
    ..In these organisms, the mechanism of vesicle formation is well understood, but the process of soluble cargo sorting has yet to be ..
  67. ncbi Anemia and anti-erythrocyte antibodies developed after repeated injections of sonicated preparations of Plasmodium berghei and Babesia rodhaini
    T Kanbara
    Department of Veterinary Surgery, College of Agriculture, University of Osaka Prefecture, Japan
    Zentralbl Bakteriol Mikrobiol Hyg A 269:100-8. 1988
    ..berghei preparations. These results suggest that both P. berghei and B. rodhaini organisms have some materials capable of inducing production of the anti-erythrocyte antibodies which mediate ..
  68. ncbi Pneumonia in a nursing home
    P J Drinka
    Wisconsin Veterans Home, King 54946-0620
    J Gen Intern Med 9:650-2. 1994
    The authors studied nursing home residents serologically to determine whether atypical organisms were causes of radiologic pneumonia. The study was conducted at the Wisconsin Veterans Home, a facility with on-site microbiology and x-ray...
  69. ncbi [Antimicrobial activities and mechanisms of carbapenem resistance in clinical isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp.]
    Y Sugino
    First Department of Internal Medicine, Nagoya University, School of Medicine
    Kansenshogaku Zasshi 75:662-70. 2001
    ..Referring to the correlations among MICs of carbapenems, MEPM showed a higher activity than IPM and PAPM in both organisms; 29 of the 94 strains (30.9%) of IPM-resistant P. aeruginosa were susceptible to MEPM...
  70. ncbi Lessons from the organization of a proficiency testing program in food microbiology by interlaboratory comparison: analytical methods in use, impact of methods on bacterial counts and measurement uncertainty of bacterial counts
    Jean Christophe Augustin
    Animal Société Aliment, Ecole Nationale Veterinaire d Alfort, Service d Hygine et Industrie des Denrees Alimentaires d Origine Animale, 7 Avenue du General de Gaulle, F 94704 Maisons Alfort Cedex, France
    Food Microbiol 23:1-38. 2006
    ..proficiency in detection of Salmonella and Listeria monocytogenes, as well as enumeration of aerobic micro-organisms, Enterobacteriaceae, coliforms, beta-glucuronidase-positive Escherichia coli, anaerobic sulfito-reducing ..
  71. doi Effects of air pollution on ecosystems and biological diversity in the eastern United States
    Gary M Lovett
    Cary Institute of Ecosystem Studies, Millbrook, New York 12545, USA
    Ann N Y Acad Sci 1162:99-135. 2009
    ..In aquatic ecosystems, effects of acidity, nitrogen, and mercury on organisms and biogeochemical processes are well documented...
  72. ncbi Antimicrobial activity of some macrophytes from Lake Manzalah (Egypt)
    M F Fareed
    Department of Home Economic, Faculty of Specific Education, Tanta University, Tanta, Egypt
    Pak J Biol Sci 11:2454-63. 2008
    ..Nine of these identified organisms were obtained from different sources, Bacillus subtilis 1020, Bacillus cereus 1080, Staphylococcus aureus, ..
  73. pmc High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus in nasopharyngeal and blood isolates of HIV-infected children from Cape Town, South
    Mark F Cotton
    Department of Paediatrics, Faculty of Health Sciences, Stellenbosch University, Cape Town South Africa
    BMC Infect Dis 8:40. 2008
    ..Our aim was to describe the organisms and antimicrobial resistance patterns in children enrolled in a prospective study comparing daily and three ..
  74. ncbi The role of UV-B radiation in aquatic and terrestrial ecosystems--an experimental and functional analysis of the evolution of UV-absorbing compounds
    J Rozema
    Department of Systems Ecology, Vrije Universiteit, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands
    J Photochem Photobiol B 66:2-12. 2002
    ..mosses) experienced higher UV-B fluxes than higher plants, which evolved later, are primitive aquatic and land organisms (cyanobacteria, algae, lichens, mosses) better adapted to present-day levels of UV-B than higher plants? ..
  75. ncbi Response of desert biological soil crusts to alterations in precipitation frequency
    Jayne Belnap
    Canyonlands Field Station, Southwest Biological Science Center, US Geological Survey, 2290 S West Resource Blvd, Moab, UT 84532, USA
    Oecologia 141:306-16. 2004
    ..Because biological soil crust organisms are only metabolically active when wet, and as soil surfaces dry quickly in deserts during late spring, summer, ..
  76. ncbi On sexual behavior and sex-role reversal
    Gerard A Schuiling
    Division of Human Biology, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands
    J Psychosom Obstet Gynaecol 26:217-23. 2005
    ..In multicellular organisms the situation is more complicated than in unicellular organisms, as it is impossible for each cell within a ..
  77. ncbi Cefepime: a review of its use in the management of hospitalized patients with pneumonia
    Therese M Chapman
    Adis International Inc, Langhorne, Pennsylvania 19407, USA
    Am J Respir Med 2:75-107. 2003
    ..Maxcef, Cepimax, Cepimex, Axepim, a parenteral fourth-generation cephalosporin, is active against many organisms causative in pneumonia...
  78. ncbi Septic arthritis in childhood
    H Caksen
    Department of Pediatrics, Yuzuncu Yil University School of Medicine, Kayseri, Turkey
    Pediatr Int 42:534-40. 2000
    ..clinical and laboratory findings, such as symptoms on admission, age, sex, joint involvement and isolated micro-organisms, and a relationship between age and joint involvement in SA...
  79. pmc Microbiology of airway disease in a cohort of patients with cystic fibrosis
    Antonietta Lambiase
    Department of Biology and Pathology Cellular and Molecular Luigi Califano, University of Naples Federico II, Italy
    BMC Infect Dis 6:4. 2006
    ..Furthermore, the increase in multidrug-resistance of such organisms makes the therapeutic management of these patients more problematic...
  80. ncbi [Standardization of laboratory tests for tuberculosis and their proficiency testing]
    Chiyoji Abe
    Kekkaku 78:541-51. 2003
    ..In the carbolfuchsin procedures (Ziehl-Neelsen, Kinyoun), acid-fast organisms appear red, and in the fluorochrome procedures (auramine O, auramine-rhodamine, acridine orange), the acid-fast ..
  81. pmc Nosocomial blood stream infection in intensive care units at Assiut University Hospitals (Upper Egypt) with special reference to extended spectrum beta-lactamase producing organisms
    Shaaban H Ahmed
    Department of Public Health and Biostatistics, Faculty of Medicine, Assiut University, Assiut, Egypt
    BMC Res Notes 2:76. 2009
    ..resistance, outcome of infection, risk factors, prevalence of extended spectrum B-lactamase producing organisms and molecular typing of Klebsiella pneumoniae strains to highlight the role of environment as a potential source ..
  82. ncbi Natural organic matter differently modulates growth of two closely related coccal green algal species
    Tatyana A Karasyova
    Leibniz Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany
    Environ Sci Pollut Res Int 14:88-93. 2007
    Humic substances (HS) comprise the majority of dead and living organic carbon, including organisms. In the environment, they are considered to be chemically inert or at least refractory...
  83. ncbi An assessment of the potential toxicity of runoff from an urban roadscape during rain events
    Sylvia Waara
    Department of Public Technology, Malardalen University, Box 883, 721 23 Västerås, Sweden
    Environ Sci Pollut Res Int 15:205-10. 2008
    ..rain events before it enters a detention pond in Västerås, Sweden, using laboratory bioassays with test organisms representing various functional groups in an aquatic ecosystem...
  84. ncbi Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards
    K D Everett
    Avian and Swine Respiratory Diseases Research Unit, National Animal Disease Center, US Department of Agriculture, Ames, IA 50010, USA or
    Int J Syst Bacteriol 49:415-40. 1999
    ..not take into account recent analysis of the ribosomal operon or recently identified obligately intracellular organisms that have a chlamydia-like developmental cycle of replication...
  85. ncbi Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs)
    Craig E Wheelock
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Rev Environ Contam Toxicol 195:117-78. 2008
    ..This class of enzymes appears to have promise for employment in environmental monitoring with a number of organisms and testing scenarios, and it is appropriate for inclusion in standard monitoring assays...
  86. ncbi Inactivation credit of UV radiation for viruses, bacteria and protozoan (oo)cysts in water: a review
    W A M Hijnen
    Kiwa Water Research Ltd, P O Box 1072, 3430 BB Nieuwegin, The Netherlands
    Water Res 40:3-22. 2006
    ..that UV radiation is very effective against (oo)cysts of Cryptosporidium and Giardia, two pathogenic micro-organisms of major importance for the safety of drinking water...
  87. ncbi Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities
    I T Paulsen
    Department of Biology, University of California at San Diego, La Jolla, CA, 92093 0116, USA
    J Mol Biol 277:573-92. 1998
    ..2) The distribution of topological types is similar in all seven organisms. (3) Transport systems belonging to 67 families were identified within the genomes of these organisms, and about ..
  88. ncbi In vitro activity of human milk against the causative organisms of ophthalmia neonatorum in Benin City, Nigeria
    S E Ibhanesebhor
    Department of Child Health, University of Benin Teaching Hospital, Edo State, Nigeria
    J Trop Pediatr 42:327-9. 1996
    The aim of the study was to evaluate the in vitro activity of term human milk on the organisms of Ophthalmia neonatorum and was a prospective study of consecutive neonates with the organism...
  89. ncbi Evolution of RNA editing sites in the mitochondrial small subunit rRNA of the Myxomycota
    Uma Krishnan
    Department of Molecular and Cell Biology, The University of Texas at Dallas, Richardson, Texas, USA
    Methods Enzymol 424:197-220. 2007
    ..of a particular RNA editing system can be obtained by comparing RNA editing characteristics in contemporary organisms whose phylogenetic relationships are known so that editing patterns in ancestral organisms can be inferred...
  90. pmc Comparison of the benzoyl-DL-arginine-naphthylamide (BANA) test, DNA probes, and immunological reagents for ability to detect anaerobic periodontal infections due to Porphyromonas gingivalis, Treponema denticola, and Bacteroides forsythus
    W J Loesche
    Department of Biological and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor 48109 1078
    J Clin Microbiol 30:427-33. 1992
    ..These three organisms are among the few cultivable plaque species that can hydrolyze the synthetic trypsin substrate benzoyl-DL-..
  91. ncbi Temperature effect on entrainment, phase shifting, and amplitude of circadian clocks and its molecular bases
    Ludger Rensing
    Institute of Cell Biology, Biochemistry and Biotechnology, University of Bremen, Germany
    Chronobiol Int 19:807-64. 2002
    ..h even in the low range of 1-2 degrees C (strong Zeitgeber effect) can entrain all ectothermic (poikilothermic) organisms. This is also reflected by the phase shifts-recorded by phase response curves (PRCs)-that are elicited by step- ..
  92. ncbi The foaming inhibitor on Nocardia and alike (FIONA) process
    Shuk Man Yu
    Electrical and Mechanical Services Department, The Hong Kong Special Administrative Region Government, P R China
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:171-7. 2007
    A new process to abate foam-causing micro-organisms of the genus of Nocardia sp. and alike was developed in the Sha Tin Sewage Treatment Works of Hong Kong in 2002 under an in-house research and development study...
  93. ncbi Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis
    M J Genin
    Pharmacia and Upjohn, Inc, Kalamazoo, Michigan 49001, USA
    J Med Chem 43:953-70. 2000
    ..prepared in an effort to expand the spectrum of activity of this class of antibiotics to include Gram-negative organisms. Pyrrole, pyrazole, imidazole, triazole, and tetrazole moieties have been used to replace the morpholine ring of ..
  94. ncbi Uptake of Escherichia coli, Vibrio cholerae non-O1 and Enterococcus durans by, and depuration of mussels (Mytilus galloprovincialis)
    Andreana Marino
    Pharmaco Biological Department, Microbiology Section, University of Messina, Contrada Annunziata, 98168 Messina, Italy
    Int J Food Microbiol 99:281-6. 2005
    ..In water contaminated with either single or mixed organisms, the bacteria accumulated rapidly in the mussels reaching high concentrations after 1 h...
  95. doi Endophytic bacteria associated with growing shoot tips of banana (Musa sp.) cv. Grand Naine and the affinity of endophytes to the host
    Pious Thomas
    Division of Biotechnology, Indian Institute of Horticultural Research, Hessarghatta Lake, Bangalore, 560089, India
    Microb Ecol 58:952-64. 2009 deep-seated shoot tips of banana suckers was made with a view to generate information on the associated organisms, potential endophytic contaminants in tissue-cultured bananas and to assess if the endophytes shared a ..
  96. ncbi Frequency of recovery of pathogens from the nasopharynx of children with acute maxillary sinusitis before and after the introduction of vaccination with the 7-valent pneumococcal vaccine
    Itzhak Brook
    Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC, USA
    Int J Pediatr Otorhinolaryngol 71:575-9. 2007
  97. ncbi Humic substances. Part 2: Interactions with organisms
    Christian E W Steinberg
    Humboldt University at Berlin, Institute of Biology, Freshwater and Stress Ecology, Germany
    Environ Sci Pollut Res Int 15:128-35. 2008
    ..Based on the paradigm of the inertness of being organic, direct interactions of dissolved HS with freshwater organisms are mostly neglected...
  98. ncbi The expanding spectrum of Bartonella infections: II. Cat-scratch disease
    J W Bass
    Department of Pediatrics, Tripler Army Medical Center, Honolulu, HI 96859 5000, USA
    Pediatr Infect Dis J 16:163-79. 1997
    ..With the use of these new taxonomy tools, several organisms previously thought to belong to other genera have been recently described as bartonellae...
  99. ncbi Biohazard potential of putative Martian organisms during missions to Mars
    David Warmflash
    Department of Biology and Biochemistry, University of Houston, TX, USA
    Aviat Space Environ Med 78:A79-88. 2007
    ..of NASA's Viking biology experiments of the 1970s have been generally interpreted as inconclusive for surface organisms, and attributed to active but nonbiological chemistries, the possibility of native surface life has never been ..
  100. doi Ciprofloxacin use and susceptibility of Gram-negative organisms to quinolone and non-quinolone antibiotics
    Judith A Troughton
    Department of Microbiology, Kelvin Laboratories, Royal Victoria Hospital, Belfast Trust, Grosvenor Road, BT126BA Belfast, UK
    J Antimicrob Chemother 66:2152-8. 2011
    ..This study aimed to investigate whether the susceptibility of Gram-negative organisms (GNO) to alternative antimicrobials (co-amoxiclav, doxycycline, aztreonam, piperacillin/tazobactam, meropenem ..
  101. ncbi Evaluation of an automated culture system for detecting bacterial contamination of platelets: an analysis with 15 contaminating organisms
    M E Brecher
    University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
    Transfusion 41:477-82. 2001
    Approximately 1 in 2000 platelet components are bacterially contaminated. The time to detection of 15 seeded organisms in platelets recovered from an automated culture system was studied.

Research Grants76

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  3. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..The "genome" is defined as the human or mouse reference genome provided by NCBI. The genomes of other organisms may be considered for sequencing only if they are consistent with the mission of CIDR and the pre-existing ..
  4. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..ability to properly respond to prolonged periods of nutritional scarcity is vital to the survival of all living organisms. Thioredoxin interacting protein (Txnip) is a key metabolic regulator of this important adaptation process...
  5. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..Project Summary/Abstract: Multicellular organisms have evolved elaborate mechanisms to enable differential and cell-type specific expression of genes...
  6. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Indeed, inhalation of as few as ten organisms is sufficient to cause severe pneumonic disease, tissue necrosis and death...
    Melanie H Cobb; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE WNKs are required for development and survival, and affect growth control in organisms ranging from worms to man...
  8. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    ..approach has already functionally characterized novel mitochondrial proteins and validated their roles in model organisms and in human disease...
  9. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    Adaptation and survival to strenuous environmental conditions are evolutionary conserved mechanisms that allow organisms to produce progeny...
  10. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..This very complex system evolved over 700 million years to protect uni- and multi- cellular organisms from infection with bacteria, fungi, viruses and other pathogens...
  11. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Ticks in the genus Dermacentor are important vectors of the organisms causing Rocky Mountain spotted fever (Rickettsia rickettsii), North Asian tick typhus (Rickettsia sibirica), ..
  12. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
    ..Both of these spirochetes are structurally and physiologically similar organisms and share several homologous proteins. T. pallidum and B...
  13. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..The effect of fatty acids on virulence gene production in the various candidate organisms will be measured utilizing a lacZ fusion system and confirmed using electrophoretic mobility shift assays (EMSAs)..
  14. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..In higher organisms including mammals, the insulin and IGF ligands and their receptors diverged and assumed more circumscribed ..
  15. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..To determine how the MPO-H2O2-Cl system kills most SA and, conversely, how the subset of surviving organisms adapt to respond to overcome MPO-derived cytotoxins in the phagosome...
  16. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ..pneumoniae, H.influenzae, N. meningitidis, Shigella, Campylobacter etc. ), Rickettsial group of organisms (Scrub typhus, Spotted fever group, Ehrlichia, Anaplasma etc...
  17. Chemical modulators of Tet-family proteins
    Anjana Rao; Fiscal Year: 2010
    ..class of enzymes, and may be used as reagents to investigate their biological functions in cells and in organisms. PUBLIC HEALTH RELEVANCE: In addition to the four major bases in the DNA alphabet - A, C, G and T - there is ..
  18. Tissue-specific delivery of probes by control of membrane trafficking of endoprot
    Blake Peterson; Fiscal Year: 2010
    ..and identifying proteases that mediate tissue-specific release of linked probes, this research will lay the foundation for the development of novel methods for tissue-specific delivery of drugs and imaging agents in higher organisms.
  19. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ..Heme is essential for virtually all organisms. In humans, heme-iron (iron-protopophyrin IX) is a significant dietary source of bio-available iron, and >60% ..
  20. Ceramide Metabolism and Photoreceptor Homeostasis
    Usha R Acharya; Fiscal Year: 2013
    ..Inherited eye diseases cause blindness in over 300 million people worldwide. Studies in model organisms are fundamental for new therapeutic strategies since they are more amenable to detailed analyses...
  21. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..They are ubiquitous, being found in all kingdoms of living organisms and plants and are referred to as Mother Nature's blowtorch, due to their ability to oxidize a vast number ..
  22. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2012
    ..The discovery of YRV is potentially of great significance because it suggests that the Y chromosome in all organisms, including humans, is very special in mediating major genomic effects on gene expression through its large ..
  23. 4th ASM Conference on Prokaryotic Cell Biology and Development
    Susan S Golden; Fiscal Year: 2012
    ..a small number of genes and proteins - as well as systems-level research uncovering regulatory networks in whole organisms and communities of organisms...
  24. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..The idea is that these organisms stimulate regulatory T cells by influencing the maturation of dendritic cells and reduce pathogenic effector ..
  25. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013 "Achilles'Heel" of mucoid, mucA mutant bacteria, we still do not know the mechanism of killing of these organisms by A-NO2-...
  26. Neuroimaging Assessments of Brain Integrity in Aging Mice
    Ai Ling Lin; Fiscal Year: 2013
    ..CR perhaps is the most well-studied one for various model organisms of extended longevity, including Saccharomyces cerevisiae, Caenorhabditis elegans, rodents and monkeys...
  27. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..aureus by colonized farmers to close family contacts, in order to determine movement of organisms to individuals lacking occupational exposure...
  28. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..focus of this project is the VRK1 protein kinase, which is involved in the regulation of cell proliferation in organisms ranging from invertebrates to mammals. The VRK1 orthologs in Drosophila and C...
  29. DNA Repair Deficiency Associated with Obesity and the Metabolic Syndrome
    R Stephen Lloyd; Fiscal Year: 2013
    ..Since it known that excessive oxidative stress can induce symptoms of Metabolic Syndrome in repair-proficient organisms, it is hypothesized that the loss of NEIL1 or OGG1 lowers the threshold at which oxidatively stress-induced ..
  30. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..These studies could potentially lead to safe, whole cell vaccines against other intracellular organisms with complex life cycles, such as mycobacterial diseases (Tuberculosis, Leprosy, and Buruli ulcer) in which ..
  31. Diverse Roles for RIC8 During G Protein Signaling in Fungi
    Katherine A Borkovich; Fiscal Year: 2012
    ..because RIC8 is conserved in filamentous fungi and G proteins are required for virulence in this class of organisms, the studies will also reveal new targets for antifungal agents that can be used to treat infections in humans.
    L Jeannine Brady; Fiscal Year: 2013
    ..secretion that will further fundamental knowledge relevant to other pathogenic streptococci and Gram-positive organisms. PUBLIC HEALTH RELEVANCE: Dental caries is an infectious disease that results in 25-30 billion dollars in annual ..
  33. Robust Peptide-Based Diagnostics of Botulinum Toxins
    John E Mueller; Fiscal Year: 2012
    ..low power, easy-to- use handheld devices for rapid monitoring and detection of toxins produced by pathogenic organisms in humans...
  34. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..the development of rational vaccines and diagnostics against other naturally emerging and genetically engineered organisms, and may also be particularly useful when rapid responses to novel infectious diseases (ID) and drug-resistant ..
  35. Durable Visible Light-activated Antivral Coatings for Fabrics Used for Personal P
    JOSEF STEPHAN SCHNEIDER; Fiscal Year: 2011 a respirator masks to minimize contact transmission onto facial skin or airborne inhalation of pathogenic organisms. Case-control studies conducted in Beijing and Hong Kong showed that wearing masks in public was independently ..
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..All organisms have therefore developed mechanisms to sense, acquire and store iron...
  37. Regulation of Genomic and Epigenomic Stability at CpG Sites
    Alfonso Bellacosa; Fiscal Year: 2013
    ..b>Organisms also establish and regulate the proper chromatin states/DNA methylation patterns at CpG sites (epigenomic ..
  38. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ..There are significant differences in the abilities of SF and typhus group (TG) organisms to trigger ROS generation and activate anti-oxidant defense mechanisms, likely due to distinct differences in ..
  39. New Rapid Diagnostic Tests for Amebiasis
    JOEL F HERBEIN; Fiscal Year: 2010
    ..Several issues confound proper diagnosis, including the litany of other organisms that can cause similar intestinal symptoms, the presence of non-pathogenic Entamoeba spp...
    John S Olson; Fiscal Year: 2010
    ..globin structures and functions, from Archaea to Bacteria to Eucarya;and (c) a framework for inhibiting the activities of globins from pathogenic organisms (Candida albicans, Aspergillus fumigatus, Bacillus anthracis, and Ascaris suum).
  41. Modulation of host immune defense by Pneumocystis beta-glucans
    ..provided by applicant): Modulation of host immune defense by Pneumocystis beta-glucans Pneumocystis are fungal organisms associated with the development of pneumonia in immunocompromised hosts...
  42. Enhanced Membrane Systems for Supplying Quality Drinking Water
    Andrew Feiring; Fiscal Year: 2013
    ..Disease are relatively common, and although these are usually not linked directly to potable water, the organisms can often be found in buildings supplied with water from municipal systems...
  43. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..Our aim is to bring at least 2 molecules to NDA with optimal doses/durations of therapy. Multi-resistant organisms have become a huge problem in patients with hospital-acquired infections...
  44. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    ..Our previous proposal focused on endotoxemia, but with the emergence of polymicrobial and gram-positive organisms leading to sepsis, we are proposing to advance our investigations into infectious models of sepsis...
  45. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    ..erythropoiesis, and many other chemical reactions that are vital for survival of almost all living organisms. Iron deficiency afflicts 30% of the world's population, and can cause anemia, developmental retardation, ..
  46. Evaluating the role of histone H3K79 methylation states in DNA damage repair in S
    Jeffrey S Thompson; Fiscal Year: 2010
    ..DNA repair in eukaryotic organisms is influenced by a family of highly conserved proteins called histones, which serve to structurally organize and ..
  47. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..However, there is a newly recognized paradigm through which cells and organisms adapt to such environmental stimuli...
  48. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
    ..Patients acquire C. difficile shortly before symptoms appear and these organisms persist in the host if antibiotic treatment had depleted the normal microbiota, creating conditions favorable ..
    Steven G Clarke; Fiscal Year: 2013
    ..These reactions are important in protecting organisms from environmental stresses and from the accumulation of spontaneous damage in aging cells...
  50. International Symposium on Proline Metabolism and Human Health
    Donald F Becker; Fiscal Year: 2010
    ..Proline has multifaceted biological and biochemical roles in a variety of organisms from bacteria to mammals...
  51. Studies on the virulence of Fillifactor alocis
    Hansel M Fletcher; Fiscal Year: 2013
    ..novel, culture-independent techniques have allowed the identification of as-yet-culturable and fastidious organisms in patients suffering from periodontitis...
    Elton T Young; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Organisms respond to a changing environment in multiple ways. Animals can walk away. For plants and single-celled microbes, leaving a stressful environment is not an option...
    William M Nauseef; Fiscal Year: 2013
    ..DESCRIPTION OF THE PPG (provided by applicant): F. tularensis is a potent pathogen when aerosolized, wherein ~ 10 organisms can produce disease...
  54. Chromosomal Control of Segregation of C. Elegans
    Abby F Dernburg; Fiscal Year: 2013
    ..To avoid doubling their chromosome number with each successive generation, all sexually reproducing organisms must undergo meiosis...
  55. Novel genetics, pathobiology &therapy of nephronophthisis-related ciliopathies
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..PC are utilized across evolution, from single cellular organisms to humans, for cellular sensory tasks, including photo-, mechano-, thermo-, olfactory, and hormonal sensation...
  56. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2012
    ..The mechanisms underlying germ cell migration and survival have been studied in genetically tractable organisms such as Drosophila, mouse and zebrafish...
  57. Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction
    Dana Boyd; Fiscal Year: 2013
    ..hypothesis as follows: we will use bioinformatic analyses that we have developed to assess the capacity of other organisms to make disulfide bonds...
    Frances M Brodsky; Fiscal Year: 2013
    ..long-term strategy for understanding complex cellular pathways of clathrin function that are relevant to human health and disease through applying knowledge of clathrin biochemistry to focused studies of cells, tissues and organisms.
  59. Analysis of the leukemic stem cell niche in chronic myeloid leukemia
    DANIELA SANDRA KRAUSE; Fiscal Year: 2013 well-known and well-established research investigators who are applying cutting-edge technologies and model organisms highly relevant to many different areas of biology, including stem cell and cancer biology and cancer genetics...
  60. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..aeruginosa, Haemophilus influenzae) and Gram-positive (Staphylococcus aureus) organisms and in two genetic backgrounds (C57BL/6 and129S6)...
    Shiou Chuan Tsai; Fiscal Year: 2010
    ..Such findings are original, because no ACCase from any other organisms has such a uniquely diverse, yet precisely controlled substrate specificity...
  62. Microfluidic-microtiter interface for rapid large-scale screenings of C. elegans
    Adela Ben Yakar; Fiscal Year: 2010
    ..Among these animals, the nematode Caenorhabditis elegans (C. elegans) is one of the most powerful model organisms providing a wide-range of genetic tools...
  63. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    ..Dental plaque, a biofilm community growing on the tooth surface, can harbor organisms that cause dental caries. The mutans streptococcal group, represented by Streptococcus mutans and S...
  64. Rickettsia ricketti and Rickettsia-like organisms in Maryland
    Douglas Norris; Fiscal Year: 2009
    ..rickettsii is not circulating in tick populations, and to identify what Rickettsia and Rickettsia-like organisms may be responsible for human clinical disease...
  65. The role of the host Ca/Mn pump in emergence of novel viral RNA recombinants
    Peter Nagy; Fiscal Year: 2010
    ..for RNA viruses to overcome immunity, jump species and change viral pathogenicity in all types of living organisms. Studies on viral RNA recombination are critical to understand the recombination process and the role of ..
  66. Chemical Biodiversity: Investigating the Phylogeny and Functional Toxins of Venom
    MANDE N HOLFORD; Fiscal Year: 2010
    ..arsenal of toxins employed by this hyper diverse group of gastropods to subdue fish, worms, and other marine organisms, provides an ideal phylogenetic model for how ecology impacts development and evolutionary change...
    Kevin Struhl; Fiscal Year: 2002
    The mechanisms by which eukaryotic organisms regulate gene expression are important for basic scientific knowledge that is necessary for understanding many complex biological phenomena including human diseases...
  68. Culture and Identification of Rickettsia-like Organisms in Maryland
    Douglas E Norris; Fiscal Year: 2010
    ..Despite non-specific detection using molecular and visual methods, the majority of these organisms have eluded accurate identification...
  69. Frontiers in Developmental Biology: Concepts, Techniques and Model Organisms
    Eric Wieschaus; Fiscal Year: 2009
    ..students in the Americas to participate in Frontiers in Developmental Biology: Concepts, Techniques and Model Organisms, the satellite short course of the Fourth International Meeting of the Latin American Society of Developmental ..
  70. Biofilm Architecture of Subgingival Plaque
    Renate Lux; Fiscal Year: 2009
    ..species presence and abundance, localization pattern, biofilm-specific morphotype, the role of as-yet-uncultured organisms and indentification of bacteria with pivotal role in biofilm structure formation...
  71. Bacterial Pathogen Amplification & Real-Time Detection
    JACK U REN; Fiscal Year: 2003
    ..These organisms include bacterial pathogens, protozoa, and viruses...
  72. Mucosal immune response of the anus in women to HPV, intercourse, smoking and OCs
    ..1) the anus has a complex microbiologic environment which requires a level of immune tolerance to commensal organisms, 2) there are often frequent exposures to simultaneous pathogens as well as trauma induced by anal intercourse, ..
  73. Development of an in vivo model of chlamydial persistence.
    Robert V Schoborg; Fiscal Year: 2010
    ..Persistent organisms may also contribute to the long-term inflammation and scarring characteristic of chlamydial diseases by ..
  74. Effect of Crohn's Disease Risk Alleles on Enteric Microbiota
    Ellen Li; Fiscal Year: 2010
    ..These changes in microbiota might reduce the proportion of protective commensal organisms and increase the numbers of proinflammatory organisms that incite intestinal inflammation...
  75. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
    Intercellular communication is essential for all multicellular organisms. A unique form of intercellular communication occurs between germ cells;0...
  76. Regulation of Mycobacterium tuberculosis proliferation
    Murty Madiraju; Fiscal Year: 2009
    ..DnaA associates multiplication of organisms and this process is believed to be regulated during intracellular maintains an active replicative state with ..