isoproterenol

Summary

Summary: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.

Top Publications

  1. Jiang Y, Walker R, Kern T, Steinle J. Application of isoproterenol inhibits diabetic-like changes in the rat retina. Exp Eye Res. 2010;91:171-9 pubmed publisher
    ..We hypothesized that application of a beta-adrenergic receptor agonist, isoproterenol, could reach the retina to elicit normal cellular signaling and inhibit the functional and morphological ..
  2. Patel D, Desai S, Gandhi H, Devkar R, Ramachandran A. Cardio protective effect of Coriandrum sativum L. on isoproterenol induced myocardial necrosis in rats. Food Chem Toxicol. 2012;50:3120-5 pubmed publisher
    The preventive effect of Coriandrum sativum L. (CS) on cardiac damage was evaluated by Isoproterenol (IP) induced cardiotoxicity model in male Wistar rats...
  3. Roy S, Stanely Mainzen Prince P. Protective effects of sinapic acid on lysosomal dysfunction in isoproterenol induced myocardial infarcted rats. Food Chem Toxicol. 2012;50:3984-9 pubmed publisher
    ..We evaluated the protective effects of sinapic acid on lysosomal dysfunction in isoproterenol induced myocardial infarcted rats...
  4. Prince P. (-) Epicatechin prevents alterations in lysosomal glycohydrolases, cathepsins and reduces myocardial infarct size in isoproterenol-induced myocardial infarcted rats. Eur J Pharmacol. 2013;706:63-9 pubmed publisher
    ..damage, altered membrane bound adenosine triphosphatases and minerals were reported previously in isoproterenol-induced myocardial infarction model...
  5. Stanely Mainzen Prince P. Preventive effects of (-) epicatechin on altered adenosine triphosphatases and minerals in isoproterenol-induced myocardial infarcted rats. J Biochem Mol Toxicol. 2012;26:516-21 pubmed publisher
    ..of (-) epicatechin on alterations in the activities/levels of adenosine triphosphatases and minerals in isoproterenol-induced myocardial infarcted rats...
  6. Chen S, Du J, Liang Y, Zhang R, Tang C, Jin H. Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury. Histol Histopathol. 2012;27:1219-26 pubmed publisher
    sulfur dioxide (SO?) could relieve isoproterenol (ISO)-induced myocardial injury, while the mechanism is unclear...
  7. Forechi L, Baldo M, Meyerfreund D, Mill J. Granulocyte colony-stimulating factor improves early remodeling in isoproterenol-induced cardiac injury in rats. Pharmacol Rep. 2012;64:643-9 pubmed
    ..Granulocyte colony-stimulating factor (G-CSF) has been used in some animal models and humans with well-established cardiovascular diseases. However, its effects in the initial stage of progressive non-ischemic heart failure are unknown...
  8. Vennila L, Pugalendi K. Efficacy of sesamol on plasma and tissue lipids in isoproterenol-induced cardiotoxicity in Wistar rats. Arch Pharm Res. 2012;35:1465-70 pubmed publisher
    ..This study was undertaken to investigate the effect of sesamol on plasma and tissue lipid profiles in isoproterenol (ISO) - induced rats...
  9. Salimeh A, Mohammadi M, Rashidi B. Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats. J Physiol Biochem. 2013;69:255-65 pubmed publisher
    ..This study was aimed to evaluate the preventive effect of diosgenin and exercise on tissue antioxidant status in isoproterenol-induced myocardial infarction (MI) in male Wistar rats...

More Information

Publications62

  1. Li H, Xie Y, Yang Q, Wang S, Zhang B, Wang J, et al. Cardioprotective effect of paeonol and danshensu combination on isoproterenol-induced myocardial injury in rats. PLoS ONE. 2012;7:e48872 pubmed publisher
    ..cardioprotective effects of paeonol and danshensu (representative active ingredient of Cortex Moutan and Radix Salviae Milthiorrhizae, respectively) on isoproterenol-induced myocardial infarction in rats and its underlying mechanisms.
  2. Guggilam A, Hutchinson K, West T, Kelly A, Galantowicz M, Davidoff A, et al. In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure. J Mol Cell Cardiol. 2013;57:47-58 pubmed publisher
    ..In summary, these data suggest that the disconnect in ?-adrenergic responsiveness between in vivo and in vitro conditions may be associated with altered myofilament Ca2+ sensitivity and connexin-43 degradation...
  3. Liu Y, Jia H, Chang X, Ding G, Zhang H, Zou Z. The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics. Mol Biosyst. 2013;9:2823-34 pubmed publisher
    ..To achieve the most comprehensive screening of the entire metabolome related to isoproterenol (ISO) induced-MI, we present a tissue targeted metabonomic study using an integrated approach of ultra-..
  4. Mukherjee D, Ghosh A, Bandyopadhyay A, Basu A, Datta S, Pattari S, et al. Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats. J Pineal Res. 2012;53:166-79 pubmed
    The present study was undertaken to explore the protective effect of melatonin against isoproterenol bitartrate (ISO)-induced rat myocardial injury and to test whether melatonin has a role in preventing myocardial injury and recovery ..
  5. Stanely Mainzen Prince P. (-) Epicatechin attenuates mitochondrial damage by enhancing mitochondrial multi-marker enzymes, adenosine triphosphate and lowering calcium in isoproterenol induced myocardial infarcted rats. Food Chem Toxicol. 2013;53:409-16 pubmed publisher
    ..The protective effects of (-) epicatechin on cardiac mitochondrial damage in isoproterenol induced myocardial infarction were evaluated in rats...
  6. Irannejad R, Tomshine J, Tomshine J, Chevalier M, Mahoney J, Steyaert J, et al. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013;495:534-8 pubmed publisher
    ..These findings provide direct support for the hypothesis that canonical GPCR signalling occurs from endosomes as well as the plasma membrane, and suggest a versatile strategy for probing dynamic conformational change in vivo...
  7. Zhuo X, Wu Y, Ni Y, Liu J, Gong M, Wang X, et al. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013;18:800-10 pubmed publisher
    ..Here we show that isoproterenol (ISO) induced aberrant endoplasmic reticulum (ER) stress and apoptotic cell death, which was inhibited by ..
  8. Ojha S, Goyal S, Sharma C, Arora S, Kumari S, Arya D. Cardioprotective effect of lycopene against isoproterenol-induced myocardial infarction in rats. Hum Exp Toxicol. 2013;32:492-503 pubmed publisher
    The present study was designed to evaluate the cardioprotective potential of lycopene (LCP) against isoproterenol (ISP)-induced myocardial infarction (MI), by assessing hemodynamic, biochemical and histopathological parameters...
  9. Sankar V, Pangayarselvi B, Prathapan A, Raghu K. Desmodium gangeticum (Linn.) DC. exhibits antihypertrophic effect in isoproterenol-induced cardiomyoblasts via amelioration of oxidative stress and mitochondrial alterations. J Cardiovasc Pharmacol. 2013;61:23-34 pubmed publisher
    ..Hypertrophy was induced by exposing H9c2 cell line to ?-adrenergic receptor agonist, isoproterenol (ISO), for 96 hours...
  10. Goyal B, Mehta A. Beneficial role of spironolactone, telmisartan and their combination on isoproterenol-induced cardiac hypertrophy. Acta Cardiol. 2012;67:203-11 pubmed
    ..and telmisartan are reported to reduce the risk of morbidity and death, direct studies on their effects on isoproterenol-induced cardiac hypertrophy are scanty...
  11. Zaitone S, Abo Gresha N. Rosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myocardial infarction in rats: role of iNOS and VEGF. Eur J Pharmacol. 2012;691:134-42 pubmed publisher
    ..Acute myocardial infarction was induced by injecting the rats with two doses of isoproterenol (85 mg/kg/24 h, s.c.)...
  12. Panda S, Kar A, Banerjee T, Sharma N. Combined effects of quercetin and atenolol in reducing isoproterenol-induced cardiotoxicity in rats: possible mediation through scavenging free radicals. Cardiovasc Toxicol. 2012;12:235-42 pubmed publisher
    In this investigation, combined effects of quercetin and atenolol in the regulation of isoproterenol (ISO)-induced cardiotoxicity have been evaluated in rats...
  13. Nichtova Z, Novotova M, Králová E, Stankovicova T. Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol. Gen Physiol Biophys. 2012;31:141-51 pubmed publisher
    ..The pathological alterations induced by isoproterenol (ISO) do not develop evenly...
  14. Ghoubay Benallaoua D, Pecha F, Goldschmidt P, Fialaire Legendre A, Chaumeil C, Laroche L, et al. Effects of isoproterenol and cholera toxin on human limbal epithelial cell cultures. Curr Eye Res. 2012;37:644-53 pubmed publisher
    Cholera toxin and isoproterenol (?-adrenergic receptor agonist) are largely used to enhance cell proliferation...
  15. Somvanshi R, Qiu X, Kumar U. Isoproterenol induced hypertrophy and associated signaling pathways are modulated by somatostatin in H9c2 cells. Int J Cardiol. 2013;167:1012-22 pubmed publisher
    ..Accordingly, SST dependent changes in signaling molecules including second messenger cAMP, PKA/CREB as well as MAPKs including ERK and p38 which are key mediators of hypertrophy and apoptosis were analyzed...
  16. Maulik S, Prabhakar P, Dinda A, Seth S. Genistein prevents isoproterenol-induced cardiac hypertrophy in rats. Can J Physiol Pharmacol. 2012;90:1117-25 pubmed publisher
    ..The present study was designed to evaluate whether genistein could prevent isoproterenol-induced cardiac hypertrophy in male Wistar rats (150-200 g, 10-12 weeks old) rats...
  17. Hussain Shaik A, Rasool S, Abdul Kareem M, Krushna G, Akhtar P, Devi K. Maslinic acid protects against isoproterenol-induced cardiotoxicity in albino Wistar rats. J Med Food. 2012;15:741-6 pubmed publisher
    ..lipoproteins, lipid peroxidation (LPO), cardiac marker enzymes, and paraoxonase (PON) in normal control and isoproterenol (ISO)-induced myocardial infarcted albino Wistar rats...
  18. Soraya H, Khorrami A, Garjani A, Maleki Dizaji N, Garjani A. Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. Pharmacol Rep. 2012;64:1476-84 pubmed
    ..In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI).
  19. Bai Y, Jones P, Guo J, Zhong X, Clark R, Zhou Q, et al. Phospholamban knockout breaks arrhythmogenic Ca²? waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circ Res. 2013;113:517-26 pubmed publisher
    ..An important question is whether these seemingly paradoxical effects of PLN-KO exacerbate or protect against Ca²?-triggered arrhythmias...
  20. Panda S, Biswas S, Kar A. Trigonelline isolated from fenugreek seed protects against isoproterenol-induced myocardial injury through down-regulation of Hsp27 and ?B-crystallin. Nutrition. 2013;29:1395-403 pubmed publisher
    Protective effects of trigonelline (TRG) isolated from fenugreek seed were evaluated in isoproterenol (ISO)-induced myocardial dysfunctions in adult rats and a proteomic approach was applied to understand its mechanism of action.
  21. Chowdhury D, Tangutur A, Khatua T, Saxena P, Banerjee S, Bhadra M. A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. J Transl Med. 2013;11:130 pubmed publisher
    The present study aimed at using a proteomics based approach to: a) analyze and contrast the proteome of the healthy and isoproterenol induced hypertrophied hearts and b) identify potential biomarkers for diagnosis of cardiac hypertrophy.
  22. Santiago D, Rios E, Shannon T. Isoproterenol increases the fraction of spark-dependent RyR-mediated leak in ventricular myocytes. Biophys J. 2013;104:976-85 pubmed publisher
    ..sparks and quantify J(leak) in intact rabbit myocytes, either in the absence or in the presence of 125 nM isoproterenol. It was found that isoproterenol treatment shifts the spark-frequency-J(leak) relationship toward an increased ..
  23. Ojha S, Bhatia J, Arora S, Golechha M, Kumari S, Arya D. Cardioprotective effects of Commiphora mukul against isoprenaline-induced cardiotoxicity: a biochemical and histopathological evaluation. J Environ Biol. 2011;32:731-8 pubmed
    ..Based on present findings, it is concluded that Commiphora mukul may be a potential preventive and therapeutic agent against the oxidative stress associated ischemic heart disease owing to antioxidant and antiperoxidative activity...
  24. Kang N, Fu L, Xu J, Han Y, Cao J, Sun J, et al. Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure. Arch Cardiovasc Dis. 2012;105:68-76 pubmed publisher
    ..Several studies have reported the benefits of testosterone in heart failure. However, the mechanisms of testosterone-induced effects on heart failure require further study...
  25. Khatua T, Padiya R, Karnewar S, Kuncha M, Agawane S, Kotamraju S, et al. Garlic provides protection to mice heart against isoproterenol-induced oxidative damage: role of nitric oxide. Nitric Oxide. 2012;27:9-17 pubmed publisher
    ..p. for last 7 days) before inducing acute myocardial infarction by isoproterenol (s.c. injection of isoproterenol 150 mgkg(-1)day(-1) for 2 days) and sacrificed after 48 h...
  26. Roy S, Mainzen Prince P. Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats. Eur J Pharmacol. 2013;699:213-8 pubmed publisher
    ..of sinapic acid on cardiac hypertrophy, dyslipidaemia and alterations in lipoproteins and electrocardiogram in isoproterenol-induced myocardial infarcted rats...
  27. Liu H, Zhang L, Lu S. Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats. Molecules. 2012;17:4281-91 pubmed publisher
    ..to evaluate the effect of quercetin on myocardial oxidative stress and immunity function impairment induced by isoproterenol in rats. To induce myocardial ischemia, Wistar rats were subcutaneously injected with isoproterenol (70 mg/kg)...
  28. Li R, Yan G, Zhang Q, Jiang Y, Sun H, Hu Y, et al. miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS Lett. 2013;587:1754-61 pubmed publisher
    ..and localization of GATA6, thereby protecting the heart against cardiomyocyte hypertrophy induced by isoproterenol (ISO)...
  29. Savergnini S, Ianzer D, Carvalho M, Ferreira A, Silva G, Marques F, et al. The novel Mas agonist, CGEN-856S, attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury in rats. PLoS ONE. 2013;8:e57757 pubmed publisher
    CGEN-856S is a novel Mas agonist. Herein, we examined the effects of this peptide on isoproterenol (ISO)-induced cardiac remodeling and myocardial infarction (MI) injury...
  30. Thounaojam M, Jadeja R, Ansarullah -, Karn S, Shah J, Patel D, et al. Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats. Exp Toxicol Pathol. 2011;63:351-6 pubmed publisher
    ..lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85 mg/kg, s.c...
  31. Wang T, Yu X, Qu S, Xu H, Han B, Sui D. Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats. Eur J Pharmacol. 2010;636:121-5 pubmed publisher
    ..to evaluate the effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats...
  32. Cheng Y, Dai D, Dai Y. Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213. Reprod Toxicol. 2010;29:421-6 pubmed publisher
    ..Adult male Sprague-Dawley rats were randomly divided into control and isoproterenol (ISO 1mg/kg, subcutaneous (s.c...
  33. Hong H, Song E, Oh E, Kabir M, Lee C, Yoo Y. Endothelin-1- and isoproterenol-induced differential protein expression and signaling pathway in HL-1 cardiomyocytes. Proteomics. 2011;11:283-97 pubmed publisher
    It is well known that the two chemical compounds endothelin-1 (ET-1) and isoproterenol (ISO) can individually induce cardiac hypertrophy through G protein-coupled receptors in cardiomyocytes...
  34. Du T, Li B, Li H, Li M, Hertz L, Peng L. Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent. J Neurochem. 2010;115:1007-23 pubmed publisher
    ..of the former of these pathways required micromolar concentrations of the ?(1)/?(2) -adrenergic agonist isoproterenol, that acted on ?(1)-adrenoceptors, whereas the latter was activated already by nanomolar concentrations, ..
  35. Liang Y, Liu D, Ochs T, Tang C, Chen S, Zhang S, et al. Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats. Lab Invest. 2011;91:12-23 pubmed publisher
    ..investigated changes in endogenous SO(2)/glutamic oxaloacetic transaminase (GOT) pathway in the development of isoproterenol (ISO)-induced myocardial injury in rats and the regulatory effect of SO(2) on cardiac function, myocardial ..
  36. Jaswal J, Lund C, Keung W, Beker D, Rebeyka I, Lopaschuk G. Isoproterenol stimulates 5'-AMP-activated protein kinase and fatty acid oxidation in neonatal hearts. Am J Physiol Heart Circ Physiol. 2010;299:H1135-45 pubmed publisher
    b>Isoproterenol increases phosphorylation of LKB, 5'-AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC), enzymes involved in regulating fatty acid oxidation...
  37. Peng H, Dai D, Ji H, Dai Y. The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. Eur J Pharmacol. 2010;634:101-6 pubmed publisher
    ..Cardiac fibroblasts isolated from neonatal rat were incubated with isoproterenol at 3 x 10(-7) M to mimic stress and were treated with either PD156707 or IRL-1038 (selective antagonists for ..
  38. Cheng D, Zhu C, Cao J, Jiang W. The protective effects of polyphenols from jujube peel (Ziziphus Jujube Mill) on isoproterenol-induced myocardial ischemia and aluminum-induced oxidative damage in rats. Food Chem Toxicol. 2012;50:1302-8 pubmed publisher
    ..cv. Dongzao) against myocardial injury (MI) induced by isoproterenol (ISO) and biotoxicity of aluminum in rats...
  39. Wang T, Meng Q, Zhang J, Bi Y, Jiang N. Study on the structure-function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol. Fitoterapia. 2010;81:783-7 pubmed publisher
    ..The pathohistological changes were ameliorated by PD and PDD2. The configuration of C-24 of funan ring was linked to the pharmacological action of 20(S)-panaxadiol and its epimeric derivatives...
  40. Patel V, Upaganlawar A, Zalawadia R, Balaraman R. Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. Eur J Pharmacol. 2010;644:160-8 pubmed publisher
    The present study was designed to investigate the cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and heart lipid ..
  41. Ferreira A, Castro C, Guatimosim S, Almeida P, Gomes E, Dias Peixoto M, et al. Attenuation of isoproterenol-induced cardiac fibrosis in transgenic rats harboring an angiotensin-(1-7)-producing fusion protein in the heart. Ther Adv Cardiovasc Dis. 2010;4:83-96 pubmed publisher
    ..To directly investigate the effects of Ang-(1-7) specifically in the heart, we generated and characterized transgenic (TG) rats which express an Ang-(1-7)-producing fusion protein driven by the alpha-MHC promoter...
  42. Kawabata K, Fujioka D, Kobayashi T, Saito Y, Obata J, Nakamura T, et al. Inhibition of secretory phospholipase A2 activity attenuates acute cardiogenic pulmonary edema induced by isoproterenol infusion in mice after myocardial infarction. J Cardiovasc Pharmacol. 2010;56:369-78 pubmed publisher
    ..edema was induced in C57BL/6J male mice by an increase in heart rate with continuous intravenous infusion of isoproterenol (ISP) (10 mg/kg/h) at 2 weeks after the creation of myocardial infarction by left coronary artery ligation...
  43. Punithavathi V, Stanely Mainzen Prince P. The cardioprotective effects of a combination of quercetin and ?-tocopherol on isoproterenol-induced myocardial infarcted rats. J Biochem Mol Toxicol. 2011;25:28-40 pubmed publisher
    The present study aims to evaluate the combined protective effects of quercetin and ?-tocopherol on isoproterenol-treated myocardial infarcted rats...
  44. Collins H, Rodrigo G. Inotropic response of cardiac ventricular myocytes to beta-adrenergic stimulation with isoproterenol exhibits diurnal variation: involvement of nitric oxide. Circ Res. 2010;106:1244-52 pubmed publisher
    ..Although >10% of cardiac gene expression displays diurnal variations, little is known of their impact on excitation-contraction coupling...
  45. Tang Y, Wang M, Le X, Meng J, Huang L, Yu P, et al. Antioxidant and cardioprotective effects of Danshensu (3-(3, 4-dihydroxyphenyl)-2-hydroxy-propanoic acid from Salvia miltiorrhiza) on isoproterenol-induced myocardial hypertrophy in rats. Phytomedicine. 2011;18:1024-30 pubmed publisher
    ..Cardiomyopathy in rats was produced using isoproterenol (Iso) treatment (2.5 mg/kg/d, s.c.) for seven days. DSS (3 and 10 mg/kg/d, i.p...
  46. Carrillo E, Escobar Y, Gonzalez G, Hernández A, Galindo J, Garcia M, et al. Posttranscriptional regulation of the ?2-subunit of cardiac L-type Ca2+ channels by MicroRNAs during long-term exposure to isoproterenol in rats. J Cardiovasc Pharmacol. 2011;58:470-8 pubmed publisher
    ..The effects of long-term ?-adrenergic administration on the expression levels of the cardiac L-type Ca channel ?2 subunit, which regulates channel trafficking and function, were characterized in adult rats...
  47. Selvaraj P, Pugalendi K. Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity. Exp Toxicol Pathol. 2012;64:449-52 pubmed publisher
    The present study examines the preventive role of hesperidin (HDN) on plasma, cardiac and hepatic lipids in isoproterenol (ISO)-induced rats...
  48. Hori Y, Yoshioka K, Kanai K, Hoshi F, Itoh N, Higuchi S. Spironolactone decreases isoproterenol-induced ventricular fibrosis and matrix metalloproteinase-2 in rats. Biol Pharm Bull. 2011;34:61-5 pubmed
    ..We investigated whether isoproterenol (ISO)-induced MMP expression/activity and cardiac fibrosis are mediated by spironolactone in rats...
  49. Soltoff S, Hedden L. Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem. 2010;285:13337-48 pubmed publisher
    ..Here we report that the beta-adrenergic ligand isoproterenol blocks increases in extracellular signal-related kinase (ERK) phosphorylation, a protein kinase C-dependent ..
  50. Molojavyi A, Lindecke A, Raupach A, Moellendorf S, Köhrer K, Gödecke A. Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Physiol Genomics. 2010;41:137-45 pubmed publisher
    ..To analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild-type (WT) controls...
  51. von Hayn K, Werthmann R, Nikolaev V, Hommers L, Lohse M, Bünemann M. Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2010;298:C324-32 pubmed publisher
    ..Stimulation of purinergic receptors decreased cAMP levels in the presence of the beta-adrenergic agonist isoproterenol. Simultaneous imaging of cAMP with Epac1-camps and of Ca(2+) with Fura 2 revealed a rise of intracellular Ca(2+..
  52. Yuan A, Li Z, Li X, Yi S, Wang S, Shi K, et al. Distinct effect of Chrysanthemum indicum Linné extracts on isoproterenol-induced growth of human hepatocellular carcinoma cells. Oncol Rep. 2009;22:1357-63 pubmed
    ..We investigated the effect of Chrysanthemum indicum Linné extracts (CILE) on isoproterenol (ISO) induced growth of human hepatocellar carcinoma (HCC) cells in correlation with the intracellular ..
  53. Pidoux G, Witczak O, Jarnæss E, Myrvold L, Urlaub H, Stokka A, et al. Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. EMBO J. 2011;30:4371-86 pubmed publisher