hereditary sensory and motor neuropathy
Summary: A group of slowly progressive inherited disorders affecting motor and sensory peripheral nerves. Subtypes include HMSNs I-VII. HMSN I and II both refer to CHARCOT-MARIE-TOOTH DISEASE. HMSN III refers to hypertrophic neuropathy of infancy. HMSN IV refers to REFSUM DISEASE. HMSN V refers to a condition marked by a hereditary motor and sensory neuropathy associated with spastic paraplegia (see SPASTIC PARAPLEGIA, HEREDITARY). HMSN VI refers to HMSN associated with an inherited optic atrophy (OPTIC ATROPHIES, HEREDITARY), and HMSN VII refers to HMSN associated with retinitis pigmentosa. (From Adams et al., Principles of Neurology, 6th ed, p1343)
- Mathieu J, Bédard F, Prevost C, Langevin P. [Motor and sensory neuropathies with or without agenesis of the corpus callosum: a radiological study of 64 cases]. Can J Neurol Sci. 1990;17:103-8 pubmed..These observations support the hypothesis of a single genetic syndrome in which the constant manifestation is the motor and sensory neuropathy. ..
- Li J, Niu B, Wang X, Hu H, Cao B. A case report of hereditary neuropathy with liability to pressure palsies accompanied by type 2 diabetes mellitus and psoriasis. Medicine (Baltimore). 2017;96:e6922 pubmed publisher..The findings indicate that diabetes mellitus may have an impact on the severity of HNPP. Physicians should consider that worsening of symptoms might result from newly diagnosed diabetes mellitus while treating patients with HNPP. ..
- Nakamura T, Kawarabayashi T, Seino Y, Shoji M. A case of hereditary neuropathy with liability to pressure palsies due to push-up exercise. Rinsho Shinkeigaku. 2017;57:383-386 pubmed publisher..HNPP should be included in the differential diagnosis for neuropathy due to slight exercise or nerve compression even when familial history is negative. ..