hemangiosarcoma

Summary

Summary: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)

Top Publications

  1. Lin J, Bigge J, Ulbright T, Montgomery E. Anastomosing hemangioma of the liver and gastrointestinal tract: an unusual variant histologically mimicking angiosarcoma. Am J Surg Pathol. 2013;37:1761-5 pubmed publisher
    ..Despite small numbers and limited follow-up information in our series, evidence to date supports that the lesion is benign. Awareness of this entity is essential to avoid overdiagnosis and unnecessary aggressive treatment...
  2. Turan M, Karadayi K, Duman M, Ozer H, Arici S, Yildirir C, et al. Small bowel tumors in emergency surgery. Ulus Travma Acil Cerrahi Derg. 2010;16:327-33 pubmed
    ..The aim of the present study was to describe the clinical presentation, diagnostic work-up, surgical therapy, and prognosis of 13 patients with small bowel tumor admitted for surgical procedures in an emergency setting...
  3. Torres K, Ravi V, Kin K, Yi M, Guadagnolo B, May C, et al. Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer. Ann Surg Oncol. 2013;20:1267-74 pubmed publisher
    ..Therefore, we sought to identify clinicopathologic factors associated with local and distant recurrence and disease-specific survival (DSS)...
  4. Bohn O, de León E, Lezama O, Rios Luna N, Sanchez Sosa S, Llombart Bosch A. Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report. Diagn Pathol. 2012;7:154 pubmed publisher
    ..Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome...
  5. Italiano A, Chen C, Thomas R, Breen M, Bonnet F, Sevenet N, et al. Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics. Cancer. 2012;118:5878-87 pubmed publisher
    ..The scale of genetic abnormalities in these pathways remains unknown in angiosarcoma (AS)...
  6. Dervisis N, Dominguez P, Newman R, Cadile C, Kitchell B. Treatment with DAV for advanced-stage hemangiosarcoma in dogs. J Am Anim Hosp Assoc. 2011;47:170-8 pubmed publisher
    b>Hemangiosarcoma (HSA) is an aggressive disease that is fairly common in the dog. The authors evaluated a doxorubicin, dacarbazine, and vincristine (DAV) combination protocol in dogs with nonresectable stage II and stage III HSA...
  7. Mohammed A, Aliyu H, Liman A, Abdullahi K, Abubakar N. Angiosarcoma of the small intestine. Ann Afr Med. 2011;10:246-8 pubmed publisher
    ..It presented in a 25-year-old woman with multiple dissemination and rapid fatality. Diagnosis was based on histological morphology using Hematoxylin and Eosin (H and E) stains, plus reticulin special stain to outline the vascular nature...
  8. Papalas J, Manavi C, Woodward J, Sangueza O, Cummings T. Angiosarcoma of the eyelid: a clinicopathologic comparison between isolated unilateral tumors and tumors demonstrating extrapalpebral involvement. Am J Dermatopathol. 2010;32:694-9 pubmed publisher
    ..When extrapalpebral involvement is ruled out by clinical and radiographic examination, patients with isolated involvement seem to fare better compared with patients with eyelid involvement secondary to more regionally extensive tumors...
  9. Terada T. Angiosarcoma of the oral cavity. Head Neck Pathol. 2011;5:67-70 pubmed publisher
    ..The Ki-67 labeling was 46%. The lymphoid tissue in the tumor was positive for CD20, CD45, CD45RO, and CD10. A pathological diagnosis of angiosarcoma was made. No metastatic lesions are found now. Radical operation is planned now...
  10. Guadagnolo B, Zagars G, Araujo D, Ravi V, Shellenberger T, Sturgis E. Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp. Head Neck. 2011;33:661-7 pubmed publisher
    ..The aim of the present analysis was to retrospectively evaluate outcomes in patients with cutaneous angiosarcoma of the face/scalp treated curatively with surgery, radiation therapy (RT), or a combination of surgery and RT...

Detail Information

Publications80

  1. Lin J, Bigge J, Ulbright T, Montgomery E. Anastomosing hemangioma of the liver and gastrointestinal tract: an unusual variant histologically mimicking angiosarcoma. Am J Surg Pathol. 2013;37:1761-5 pubmed publisher
    ..Despite small numbers and limited follow-up information in our series, evidence to date supports that the lesion is benign. Awareness of this entity is essential to avoid overdiagnosis and unnecessary aggressive treatment...
  2. Turan M, Karadayi K, Duman M, Ozer H, Arici S, Yildirir C, et al. Small bowel tumors in emergency surgery. Ulus Travma Acil Cerrahi Derg. 2010;16:327-33 pubmed
    ..The aim of the present study was to describe the clinical presentation, diagnostic work-up, surgical therapy, and prognosis of 13 patients with small bowel tumor admitted for surgical procedures in an emergency setting...
  3. Torres K, Ravi V, Kin K, Yi M, Guadagnolo B, May C, et al. Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer. Ann Surg Oncol. 2013;20:1267-74 pubmed publisher
    ..Therefore, we sought to identify clinicopathologic factors associated with local and distant recurrence and disease-specific survival (DSS)...
  4. Bohn O, de León E, Lezama O, Rios Luna N, Sanchez Sosa S, Llombart Bosch A. Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report. Diagn Pathol. 2012;7:154 pubmed publisher
    ..Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome...
  5. Italiano A, Chen C, Thomas R, Breen M, Bonnet F, Sevenet N, et al. Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics. Cancer. 2012;118:5878-87 pubmed publisher
    ..The scale of genetic abnormalities in these pathways remains unknown in angiosarcoma (AS)...
  6. Dervisis N, Dominguez P, Newman R, Cadile C, Kitchell B. Treatment with DAV for advanced-stage hemangiosarcoma in dogs. J Am Anim Hosp Assoc. 2011;47:170-8 pubmed publisher
    b>Hemangiosarcoma (HSA) is an aggressive disease that is fairly common in the dog. The authors evaluated a doxorubicin, dacarbazine, and vincristine (DAV) combination protocol in dogs with nonresectable stage II and stage III HSA...
  7. Mohammed A, Aliyu H, Liman A, Abdullahi K, Abubakar N. Angiosarcoma of the small intestine. Ann Afr Med. 2011;10:246-8 pubmed publisher
    ..It presented in a 25-year-old woman with multiple dissemination and rapid fatality. Diagnosis was based on histological morphology using Hematoxylin and Eosin (H and E) stains, plus reticulin special stain to outline the vascular nature...
  8. Papalas J, Manavi C, Woodward J, Sangueza O, Cummings T. Angiosarcoma of the eyelid: a clinicopathologic comparison between isolated unilateral tumors and tumors demonstrating extrapalpebral involvement. Am J Dermatopathol. 2010;32:694-9 pubmed publisher
    ..When extrapalpebral involvement is ruled out by clinical and radiographic examination, patients with isolated involvement seem to fare better compared with patients with eyelid involvement secondary to more regionally extensive tumors...
  9. Terada T. Angiosarcoma of the oral cavity. Head Neck Pathol. 2011;5:67-70 pubmed publisher
    ..The Ki-67 labeling was 46%. The lymphoid tissue in the tumor was positive for CD20, CD45, CD45RO, and CD10. A pathological diagnosis of angiosarcoma was made. No metastatic lesions are found now. Radical operation is planned now...
  10. Guadagnolo B, Zagars G, Araujo D, Ravi V, Shellenberger T, Sturgis E. Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp. Head Neck. 2011;33:661-7 pubmed publisher
    ..The aim of the present analysis was to retrospectively evaluate outcomes in patients with cutaneous angiosarcoma of the face/scalp treated curatively with surgery, radiation therapy (RT), or a combination of surgery and RT...
  11. Babarović E, Zamolo G, Mustac E, Strcic M. High grade angiosarcoma arising in fibroadenoma. Diagn Pathol. 2011;6:125 pubmed publisher
    ..Here we present a case of a 53 year old, postmenopausal women with primary angiosarcoma arising in fibroadenoma. To our knowledge, this is the first case described in the literature to date...
  12. Seinen J, Styring E, Verstappen V, Vult von Steyern F, Rydholm A, Suurmeijer A, et al. Radiation-associated angiosarcoma after breast cancer: high recurrence rate and poor survival despite surgical treatment with R0 resection. Ann Surg Oncol. 2012;19:2700-6 pubmed publisher
    ..We characterized a population-based cohort of patients with secondary angiosarcomas from two tertiary hospitals to investigate this complication with respect to surgical treatment and outcome...
  13. McKeown D, Boland P. Stewart-Treves syndrome: a case report. Ann R Coll Surg Engl. 2013;95:e80-2 pubmed publisher
    ..We urge vigilance and regular follow-up appointments for patients following a mastectomy with chronic lymphoedema to facilitate prevention or early treatment of this devastating syndrome. ..
  14. Asa S, Murai A, Murakami M, Hoshino Y, Mori T, Maruo K, et al. Expression of platelet-derived growth factor and its receptors in spontaneous canine hemangiosarcoma and cutaneous hemangioma. Histol Histopathol. 2012;27:601-7 pubmed publisher
    b>Hemangiosarcoma (HSA) is a malignant neoplasia of vascular endothelial cells (ECs)...
  15. Boston S, Higginson G, Monteith G. Concurrent splenic and right atrial mass at presentation in dogs with HSA: a retrospective study. J Am Anim Hosp Assoc. 2011;47:336-41 pubmed publisher
    The objective of this retrospective study was to evaluate the presence of concurrent splenic and cardiac hemangiosarcoma (HSA)...
  16. Tamburini B, Phang T, Fosmire S, Scott M, Trapp S, Duckett M, et al. Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer. 2010;10:619 pubmed publisher
    The etiology of hemangiosarcoma remains incompletely understood. Its common occurrence in dogs suggests predisposing factors favor its development in this species...
  17. Agulnik M, Yarber J, Okuno S, von Mehren M, Jovanovic B, Brockstein B, et al. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol. 2013;24:257-63 pubmed publisher
    ..To determine efficacy and safety of bevacizumab, a recombinant humanized antibody against vascular endothelial growth factor (VEGF), in the treatment of metastatic or locally advanced angiosarcoma and epithelioid hemangioendotheliomas...
  18. Lin X, Liu Y, Zhang Y, Yu J, Wang E. The co-expression of cytokeratin and p63 in epithelioid angiosarcoma of the parotid gland: a diagnostic pitfall. Diagn Pathol. 2012;7:118 pubmed publisher
    ..Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6548916707504750...
  19. Vertse G, Svastics E, Iványi A. [Postirradiation angiosarcoma of the breast]. Magy Seb. 2010;63:164-7 pubmed publisher
    ..Only radical surgical intervention can provide successful treatment. Authors present a case of a 56-y-old woman who underwent BCT and radiotherapy. 10 years later secondary AS occurred in the remaining breast...
  20. Collard F, Nadeau M, Carmel E. Laparoscopic splenectomy for treatment of splenic hemangiosarcoma in a dog. Vet Surg. 2010;39:870-2 pubmed publisher
    ..To report laparoscopic splenectomy in a dog...
  21. Young R, Brown N, Reed M, Hughes D, Woll P. Angiosarcoma. Lancet Oncol. 2010;11:983-91 pubmed publisher
    ..In this review we discuss angiosarcoma and its current management, with a focus on clinical trials investigating the treatment of advanced disease...
  22. Choorapoikayil S, Kuiper R, de Bruin A, den Hertog J. Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma. Dis Model Mech. 2012;5:241-7 pubmed publisher
    ..A single tumor was identified in 42 ptena(-/-)ptenb(+/-) fish and was also diagnosed as hemangiosarcoma. Immunohistochemistry indicated that the tumor cells in ptena(+/-)ptenb(-/-) and ptena(-/-)ptenb(+/-) fish ..
  23. Crumbaker D, Rooney M, Case J. Thoracoscopic subtotal pericardiectomy and right atrial mass resection in a dog. J Am Vet Med Assoc. 2010;237:551-4 pubmed publisher
    ..A 10-year-old spayed female Corgi mix was examined for a 3-week history of lethargy and weight gain...
  24. Terada T. Fatal poorly differentiated angiosarcoma of the scalp. Int J Clin Exp Pathol. 2010;3:541-4 pubmed
    ..Chemoradiation and immunotherapy were performed. However, the tumor recurred several times, and ultimately metastasized to the systemic bones and lungs. The patient died of systemic carcinomatosis 33 months after the first manifestation...
  25. Brown J, Folpe A, Rao P, Lazar A, Paner G, Gupta R, et al. Primary vascular tumors and tumor-like lesions of the kidney: a clinicopathologic analysis of 25 cases. Am J Surg Pathol. 2010;34:942-9 pubmed publisher
  26. Kirby G, Mackay A, Grant A, Woods P, McEwen B, Khanna C, et al. Concentration of lipocalin region of collagen XXVII alpha 1 in the serum of dogs with hemangiosarcoma. J Vet Intern Med. 2011;25:497-503 pubmed publisher
    b>Hemangiosarcoma (HSA) is a common malignancy of dogs with characteristic early, aggressive metastasis. Diagnosis of HSA is challenging because of lack of sensitive and specific diagnostic tests.
  27. Uto T, Bando M, Yamauchi H, Nakayama M, Ohata M, Mato N, et al. Primary cardiac angiosarcoma of the right auricle with difficult-to-treat bilateral pleural effusion. Intern Med. 2011;50:2371-4 pubmed
    ..Immunohistochemical staining showed that the tumor cells expressed endothelial markers such as CD31 and CD34 antibodies, and factor VIII-related protein. These findings supported the diagnosis of a poorly differentiated angiosarcoma...
  28. Ray Coquard I, Italiano A, Bompas E, Le Cesne A, Robin Y, Chevreau C, et al. Sorafenib for patients with advanced angiosarcoma: a phase II Trial from the French Sarcoma Group (GSF/GETO). Oncologist. 2012;17:260-6 pubmed publisher
    ..We investigated the antitumor activity of sorafenib in patients with metastatic or advanced angiosarcomas in a phase II trial...
  29. Lyles S, Milner R, Kow K, Salute M. In vitro effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine hemangiosarcoma cell lines. Vet Comp Oncol. 2012;10:223-35 pubmed publisher
    This study evaluated the in vitro activity of masitinib mesylate against canine hemangiosarcoma (HSA) cell lines after treatment with increasing concentrations of masitinib mesylate (0.01-100 µM) for 24, 48 and 72 h...
  30. Zacarias Föhrding L, Macher A, Braunstein S, Knoefel W, Topp S. Small intestine bleeding due to multifocal angiosarcoma. World J Gastroenterol. 2012;18:6494-500 pubmed publisher
    ..Therefore, a quick clinical and histological diagnosis and decisive measures including surgery and adjuvant chemotherapy should be the aim...
  31. Hasenstein J, Kasmerchak K, Buehler D, Hafez G, Cleary K, Moody J, et al. Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia. 2012;14:131-40 pubmed
    ..These data identify Tie2 antagonism as a potential novel, targeted therapy for angiosarcomas and provide a foundation for further investigation of Tie2 inhibition, alone and in combinations, in the management of this disease...
  32. Kao Y, Chow J, Wang K, Fang C, Chu J, Chen C. Primary pleural angiosarcoma as a mimicker of mesothelioma: a case report **VS**. Diagn Pathol. 2011;6:130 pubmed publisher
    ..We report the case of a 49-year-old male patient with primary pleural angiosarcoma, who presented with initial hemothorax, followed by a rapid progress to an inoperable status...
  33. Shon W, Jenkins S, Ross D, Seitz R, Beck R, Ring B, et al. Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness. J Cutan Pathol. 2011;38:961-6 pubmed publisher
    ..Our study confirms the poor prognosis of angiosarcoma. Vasoformative angiosarcoma may have a more favorable prognosis. A lack of TLE3 expression in cutaneous angiosarcoma may reflect differing pathogenesis...
  34. Bösmüller H, Gruber C, Haitchi Petnehazy S, Wagner D, Webersinke G, Hauptmann S. Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient. Diagn Pathol. 2011;6:65 pubmed publisher
    ..Most reports refer to younger individuals, aged from 7 to 46 years, and only 2 case reports could be found for patients older than 64 years. Here we present a very unusual case of angiosarcoma in a 81-year-old patient...
  35. Jallali N, James S, Searle A, Ghattaura A, Hayes A, Harris P. Surgical management of radiation-induced angiosarcoma after breast conservation therapy. Am J Surg. 2012;203:156-61 pubmed publisher
    ..Radiation-induced angiosarcoma (RA) is a well-recognized complication of breast conservation therapy (BCT)...
  36. Chisholm K, Chang K, Truong M, Kwok S, West R, Heerema McKenney A. ?-Adrenergic receptor expression in vascular tumors. Mod Pathol. 2012;25:1446-51 pubmed publisher
    ..Additional study is warranted, as therapeutic options are limited for some patients with these lesions...
  37. Guo T, Zhang L, Chang N, Singer S, Maki R, Antonescu C. Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. Genes Chromosomes Cancer. 2011;50:25-33 pubmed publisher
    ..Secondary genetic hits, such as FLT4 gene coamplification or KDR mutations, may play a role in tumor progression as well as potential therapeutic targeting...
  38. Liu D, Smith H, Lee M, Djeric M. Small intestinal angiosarcoma masquerading as an appendiceal abscess. Ann R Coll Surg Engl. 2013;95:e22-4 pubmed publisher
    ..We describe a case of a terminal ileum angiosarcoma masquerading as an appendiceal abscess, and discuss salient clinicopathological features in diagnosing and managing this disease...
  39. Kambayashi Y, Fujimura T, Furudate S, Hashimoto A, Haga T, Aiba S. Comparison of immunosuppressive and cytotoxic cells in angiosarcoma: development of a possible supportive therapy for angiosarcoma. Dermatology. 2013;227:14-20 pubmed publisher
    ..These findings suggest that a high number of immunosuppressive cells might be related to the prognosis of AS, and that a combination of docetaxel with bisphosphonate risedronate sodium might be effective for MMP-9-expressing AS...
  40. Lindford A, Bohling T, Vaalavirta L, Tenhunen M, Jahkola T, Tukiainen E. Surgical management of radiation-associated cutaneous breast angiosarcoma. J Plast Reconstr Aesthet Surg. 2011;64:1036-42 pubmed publisher
    ..Median follow-up was 81 months. Six patients were alive and disease-free at the end of the study period. Aggressive surgical resection with wide margins is essential to reduce local recurrence and improve survival...
  41. Penel N, Marreaud S, Robin Y, Hohenberger P. Angiosarcoma: state of the art and perspectives. Crit Rev Oncol Hematol. 2011;80:257-63 pubmed publisher
    ..Biological evidences for the key role of angiogentic factors have been accumulated during the last years and support the further investigation of anti-angiogenetic agents alone and almost combination with chemotherapy in such disease...
  42. Ohguri T, Imada H, Nomoto S, Yahara K, Hisaoka M, Hashimoto H, et al. Angiosarcoma of the scalp treated with curative radiotherapy plus recombinant interleukin-2 immunotherapy. Int J Radiat Oncol Biol Phys. 2005;61:1446-53 pubmed
    ..Arterial or intratumoral administration combined with systemic administration of rIL-2 may prolong survival. Additional studies with detailed treatment protocols are recommended. ..
  43. Heller D, Clifford C, Goldschmidt M, Holt D, Manfredi M, Sorenmo K. Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. Vet Pathol. 2005;42:350-3 pubmed
    To determine whether cyclooxygenase-2 (COX-2) is expressed in canine hemangiosarcoma (HSA), histiocytic sarcoma (HS), and grade-II mast cell tumor (MCT), we performed immunohistochemistry using COX-2 antibodies in the aforementioned ..
  44. Molina E, Hernandez A. Clinical manifestations of primary hepatic angiosarcoma. Dig Dis Sci. 2003;48:677-82 pubmed
    ..The presentation and preexisting factors are valuable in establishing a clinical suspicion to diagnose this rare tumor. Although imaging studies are helpful, they are not conclusive, and liver biopsy is usually required. ..
  45. Demartelaere S, Roberts D, Burgess M, Morrison W, Pisters P, Sturgis E, et al. Neoadjuvant chemotherapy-specific and overall treatment outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement. Head Neck. 2008;30:639-46 pubmed publisher
    ..The goal of this report was to investigate the overall treatment outcomes and the neoadjuvant chemotherapy-specific outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement...
  46. Mayir B, Colak T, Dinckan A. [Spontaneous spleen rupture due to primary splenic angiosarcoma: a case report]. Ulus Travma Acil Cerrahi Derg. 2007;13:313-5 pubmed
    ..Spleen angiosarcoma must be considered in the differential diagnosis of patients with unexplained anemia, splenic mass and splenomegaly. It has rapid course and poor prognosis. Splenectomy must be performed because of threat of rupture. ..
  47. Murinello A, Mendonça P, Abreu A, Santos A, Roquete J, Pinto E, et al. Cardiac angiosarcoma--a review. Rev Port Cardiol. 2007;26:577-84 pubmed
    ..Urticaria is not generally assumed by most authors to be associated with malignancy, but there are rare reports of its association with some malignant tumors...
  48. Grewal J, Daniel A, Carson E, Catanzaro A, Shehab T, Tworek J. Rapidly progressive metastatic multicentric epithelioid angiosarcoma of the small bowel: a case report and a review of literature. Int J Colorectal Dis. 2008;23:745-56 pubmed
    ..Treatment usually involves surgical resection of the bleeding lesions and frequent blood transfusions for symptom alleviation. ..
  49. Montgomery E, Epstein J. Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma. Am J Surg Pathol. 2009;33:1364-9 pubmed publisher
    ..Its anastomosing appearance can lead to concern for angiosarcoma but, despite small numbers and limited follow-up in our series, evidence to date supports that the lesion is benign. ..
  50. Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, et al. Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. J Dermatol Sci. 2007;48:64-6 pubmed
  51. Abbott R, Levy A, Aguilera N, Gorospe L, Thompson W. From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation. Radiographics. 2004;24:1137-63 pubmed
    ..Splenectomy may be required for definitive evaluation of a splenic mass with atypical features...
  52. Dickerson E, Thomas R, Fosmire S, Lamerato Kozicki A, Bianco S, Wojcieszyn J, et al. Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. Vet Pathol. 2005;42:618-32 pubmed
    ..that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma)...
  53. Contreras A, Malpica A. Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. Int J Gynecol Pathol. 2009;28:453-7 pubmed publisher
    ..To date, only 5 cases of angiosarcoma arising in a mature cystic teratoma of the ovary have been reported. Herein, we report the clinicopathologic features of one such case. A review of the literature is also presented. ..
  54. Azimi N, Selter J, Abott J, Cabin H, Hutner A, Copel J, et al. Angiosarcoma in a pregnant woman presenting with pericardial tamponade--a case report and review of the literature. Angiology. 2006;57:251-7 pubmed
    ..They review the literature involving pericardial disease in pregnancy and discuss important issues in management and include a discussion of angiosarcoma. ..
  55. Knop F, Hansen M, Meisner S. Small-bowel hemangiosarcoma and capsule endoscopy. Endoscopy. 2003;35:637 pubmed
  56. Gagner J, Yim J, Yang G. Fine-needle aspiration cytology of epithelioid angiosarcoma: a diagnostic dilemma. Diagn Cytopathol. 2005;33:429-33 pubmed
    ..This case illustrates that morphology with clinicopathologic correlation tends to be a better guide than available special techniques. ..
  57. den Bakker M, Ansink A, Ewing Graham P. "Cutaneous-type" angiosarcoma arising in a mature cystic teratoma of the ovary. J Clin Pathol. 2006;59:658-60 pubmed
    ..Vascular tumours have only rarely been described as secondary somatic tumours in ovarian teratomas. The diagnostic features and complications of such tumours are described. ..
  58. Selk A, Wehrli B, Taylor B. Chylous ascites secondary to small-bowel angiosarcoma. Can J Surg. 2004;47:383-4 pubmed
  59. Hammond T, Pesillo Crosby S. Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003-2005). J Am Vet Med Assoc. 2008;232:553-8 pubmed publisher
    To determine prevalence of splenic hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion and to identify factors that could differentiate between dogs with hemangiosarcoma and dogs with other ..
  60. Scow J, Reynolds C, Degnim A, Petersen I, Jakub J, Boughey J. Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience. J Surg Oncol. 2010;101:401-7 pubmed publisher
    ..Angiosarcoma of the breast can be divided into primary and secondary. The objective was to determine clinicopathologic factors associated with breast angiosarcoma and to compare primary versus secondary angiosarcoma...
  61. Itakura E, Yamamoto H, Oda Y, Tsuneyoshi M. Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas. J Surg Oncol. 2008;97:74-81 pubmed
    ..The majority of angiosarcomas are thought to originate from vascular endothelia and spread via bloodstream to lung, but lymphatic metastases can occur...
  62. Miura H, Asada Y. Treatment of eyelid lesion of angiosarcoma with facial artery recombinant interleukin-2 (rIL-2) injection. J Am Acad Dermatol. 2006;54:907-8 pubmed
  63. Horger M. [Spontaneously ruptured hemangiosarcoma of the liver]. Rofo. 2003;175:307-8 pubmed
  64. Schlemmer M, Reichardt P, Verweij J, Hartmann J, Judson I, Thyss A, et al. Paclitaxel in patients with advanced angiosarcomas of soft tissue: a retrospective study of the EORTC soft tissue and bone sarcoma group. Eur J Cancer. 2008;44:2433-6 pubmed publisher
    ..The objective of this retrospective study was to assess the anti-tumour activity of this compound in a multicentre setting...
  65. Mendenhall W, Mendenhall C, Werning J, Reith J, Mendenhall N. Cutaneous angiosarcoma. Am J Clin Oncol. 2006;29:524-8 pubmed
    ..To discuss the treatment and outcomes for cutaneous angiosarcoma...
  66. Klaunig J, Kamendulis L. Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas. Toxicol Lett. 2005;156:107-15 pubmed
  67. Maier A, Bataille F, Krenz D, Anthuber M. [Angiosarcoma as a rare differential diagnosis in spontaneous rupture of the spleen]. Chirurg. 2004;75:70-4 pubmed
    ..Due to the small number of reported cases, there are no guidelines for adjuvant or palliative therapy, and up to today all adjuvant means of radiotherapy and chemotherapy have not improved the prognosis of the patients...
  68. Morgan M, Swann M, Somach S, Eng W, Smoller B. Cutaneous angiosarcoma: a case series with prognostic correlation. J Am Acad Dermatol. 2004;50:867-74 pubmed
    ..Cutaneous angiosarcoma (CA) is a rare and aggressive endothelial-derived sarcoma. Few large studies have examined the clinicopathologic and prognostic attributes of CA...
  69. Stacher E, Gruber Mösenbacher U, Halbwedl I, Dei Tos A, Cavazza A, Papotti M, et al. The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: new potential therapeutic targets?. Lung Cancer. 2009;65:49-55 pubmed publisher
    ..The observed positivity for the factors of the VEGF-signalling pathway points towards a possible new therapeutic option in the therapy of pulmonary vascular tumors by a blockade of the ligands or their receptors...
  70. Thompson W, Levy A, Aguilera N, Gorospe L, Abbott R. Angiosarcoma of the spleen: imaging characteristics in 12 patients. Radiology. 2005;235:106-15 pubmed
    ..To retrospectively review clinical, pathologic, and imaging features of angiosarcoma of the spleen in 12 patients...
  71. Koch M, Nielsen G, Yoon S. Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangioperictyomas. J Surg Oncol. 2008;97:321-9 pubmed publisher
    ..Adjuvant chemotherapy is unproven but can be considered. For patients with advanced disease, various chemotherapeutic regimens may result in meaningful responses in a minority of patients...
  72. Papotti M, Arrondini M, Tavaglione V, Veltri A, Volante M. Diagnostic controversies in vascular proliferations of the thyroid gland. Endocr Pathol. 2008;19:175-83 pubmed publisher
  73. Raina V, Sengar M, Shukla N, Deo S, Mohanty B, Sharma D, et al. Complete response from thalidomide in angiosarcoma after treatment of breast cancer. J Clin Oncol. 2007;25:900-1 pubmed
  74. Chandler H, Newkirk K, Kusewitt D, Dubielzig R, Colitz C. Immunohistochemical analysis of ocular hemangiomas and hemangiosarcomas in dogs. Vet Ophthalmol. 2009;12:83-90 pubmed publisher
    ..To determine if molecular markers typically associated with ultraviolet exposure could be detected in canine ocular hemangiomas (HA) and hemangiosarcomas (HSA)...
  75. Woldemeskel M, Rajeev S. Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors. Vet Res Commun. 2010;34:153-60 pubmed publisher
    Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections...
  76. Park M, Ravi V, Araujo D. Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. Curr Opin Oncol. 2010;22:351-5 pubmed publisher
    ..Therapeutic agents that target this pathway are reviewed...
  77. Luini A, Gatti G, Diaz J, Botteri E, Oliveira E, Cecilio Sahium de Almeida R, et al. Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature. Breast Cancer Res Treat. 2007;105:81-5 pubmed
    ..We report the experience of the European Institute of Oncology with this unusual disease from January 1996 to January 2006: sixteen patients with angiosarcoma, 9 (56%) of whom had primary AB and 7 (44%), secondary AB, are discussed...
  78. Koontz B, Miles E, Rubio M, Madden J, Fisher S, Scher R, et al. Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies. Head Neck. 2008;30:262-6 pubmed
    ..Given the vascular nature of angiosarcoma and the need for better treatment of this disease, we investigated the concurrent use of bevacizumab with preoperative radiotherapy for head and neck angiosarcoma...
  79. Snyder J, Lipitz L, Skorupski K, Shofer F, Van Winkle T. Secondary intracranial neoplasia in the dog: 177 cases (1986-2003). J Vet Intern Med. 2008;22:172-7 pubmed publisher
    ..This study investigates the frequency, location, and clinical findings associated with 177 secondary brain tumors in dogs...
  80. Isa N, James D, Saw T, Pennisi R, Gough I. Primary angiosarcoma of the thyroid gland with recurrence diagnosed by fine needle aspiration: a case report. Diagn Cytopathol. 2009;37:427-32 pubmed publisher
    ..Chemotherapy was started but she succumbed to the disease 7 months after diagnosis. The cytological, histopathological, immunohistochemical findings, and the clinical course are discussed...