periosteum

Summary

Summary: Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.

Top Publications

  1. Wang Q, Huang C, Zeng F, Xue M, Zhang X. Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair. Am J Pathol. 2010;177:3100-11 pubmed publisher
    While the essential role of periosteum in cortical bone repair and regeneration is well established, the molecular pathways that control the early osteogenic and chondrogenic differentiation of periosteal stem/progenitor cells during ..
  2. Chen C, Chang C, Su C, Wang K, Liu H, Yu C, et al. Arthroscopic single-bundle anterior cruciate ligament reconstruction with periosteum-enveloping hamstring tendon graft: clinical outcome at 2 to 7 years. Arthroscopy. 2010;26:907-17 pubmed publisher
    In this case-series outcome study, we present our surgical technique for single-bundle anterior cruciate ligament (ACL) reconstruction with periosteum-enveloping hamstring tendon graft at a minimum of 2 years' follow-up.
  3. Li J, Zhao Q, Wang E, Zhang C, Wang G, Yuan Q. Transplantation of Cbfa1-overexpressing adipose stem cells together with vascularized periosteal flaps repair segmental bone defects. J Surg Res. 2012;176:e13-20 pubmed publisher
    ..The present study aims to promote the effect of bone defect repair using the tissue engineered bone in combination with vascularized periosteal flaps...
  4. Bivi N, Condon K, Allen M, Farlow N, Passeri G, Brun L, et al. Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation. J Bone Miner Res. 2012;27:374-89 pubmed publisher
    ..Thus, Cx43 is essential in a cell-autonomous fashion in vivo and in vitro for osteocyte survival and for controlling the expression of osteocytic genes that affect osteoclast and osteoblast function...
  5. Ball M, Bonzani I, Bovis M, Williams A, Stevens M. Human periosteum is a source of cells for orthopaedic tissue engineering: a pilot study. Clin Orthop Relat Res. 2011;469:3085-93 pubmed publisher
    ..Periosteal cells are important in embryogenesis, fracture healing, and cartilage repair and could provide cells for osteochondral tissue engineering...
  6. Knothe U, Dolejs S, Matthew Miller R, Knothe Tate M. Effects of mechanical loading patterns, bone graft, and proximity to periosteum on bone defect healing. J Biomech. 2010;43:2728-37 pubmed publisher
    ..mechanobiological factors, including mechanical loading patterns, presence of bone graft, and proximity to the periosteum, correlate to de novo tissue generation and healing in critical sized long bone defects, which are enveloped by ..
  7. Zhao L, Zhao J, Wang S, Xia Y, Liu J, He J, et al. Evaluation of immunocompatibility of tissue-engineered periosteum. Biomed Mater. 2011;6:015005 pubmed publisher
    Tissue-engineered periosteum (TEP) and 'intramembranous ossification' may be an alternative approach to bone tissue engineering...
  8. Fan W, Crawford R, Xiao Y. Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model. Biomaterials. 2010;31:3580-9 pubmed publisher
    The periosteum plays an indispensable role in both bone formation and bone defect healing...
  9. Becker S, Douglas T, Acil Y, Seitz H, Sivananthan S, Wiltfang J, et al. Biocompatibility of individually designed scaffolds with human periosteum for use in tissue engineering. J Mater Sci Mater Med. 2010;21:1255-62 pubmed publisher
    ..Human periosteum cells were cultured using an osteogenic medium consisting of Dulbecco's modified Eagle medium supplemented with ..
  10. Zhao L, Zhao J, Wang S, Wang J, Liu J. Comparative study between tissue-engineered periosteum and structural allograft in rabbit critical-sized radial defect model. J Biomed Mater Res B Appl Biomater. 2011;97:1-9 pubmed publisher
    The purpose of this study was to compare the efficacy of tissue-engineered periosteum (TEP) to allgeneic bone in repairing segmental bone defect...

Detail Information

Publications62

  1. Wang Q, Huang C, Zeng F, Xue M, Zhang X. Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair. Am J Pathol. 2010;177:3100-11 pubmed publisher
    While the essential role of periosteum in cortical bone repair and regeneration is well established, the molecular pathways that control the early osteogenic and chondrogenic differentiation of periosteal stem/progenitor cells during ..
  2. Chen C, Chang C, Su C, Wang K, Liu H, Yu C, et al. Arthroscopic single-bundle anterior cruciate ligament reconstruction with periosteum-enveloping hamstring tendon graft: clinical outcome at 2 to 7 years. Arthroscopy. 2010;26:907-17 pubmed publisher
    In this case-series outcome study, we present our surgical technique for single-bundle anterior cruciate ligament (ACL) reconstruction with periosteum-enveloping hamstring tendon graft at a minimum of 2 years' follow-up.
  3. Li J, Zhao Q, Wang E, Zhang C, Wang G, Yuan Q. Transplantation of Cbfa1-overexpressing adipose stem cells together with vascularized periosteal flaps repair segmental bone defects. J Surg Res. 2012;176:e13-20 pubmed publisher
    ..The present study aims to promote the effect of bone defect repair using the tissue engineered bone in combination with vascularized periosteal flaps...
  4. Bivi N, Condon K, Allen M, Farlow N, Passeri G, Brun L, et al. Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation. J Bone Miner Res. 2012;27:374-89 pubmed publisher
    ..Thus, Cx43 is essential in a cell-autonomous fashion in vivo and in vitro for osteocyte survival and for controlling the expression of osteocytic genes that affect osteoclast and osteoblast function...
  5. Ball M, Bonzani I, Bovis M, Williams A, Stevens M. Human periosteum is a source of cells for orthopaedic tissue engineering: a pilot study. Clin Orthop Relat Res. 2011;469:3085-93 pubmed publisher
    ..Periosteal cells are important in embryogenesis, fracture healing, and cartilage repair and could provide cells for osteochondral tissue engineering...
  6. Knothe U, Dolejs S, Matthew Miller R, Knothe Tate M. Effects of mechanical loading patterns, bone graft, and proximity to periosteum on bone defect healing. J Biomech. 2010;43:2728-37 pubmed publisher
    ..mechanobiological factors, including mechanical loading patterns, presence of bone graft, and proximity to the periosteum, correlate to de novo tissue generation and healing in critical sized long bone defects, which are enveloped by ..
  7. Zhao L, Zhao J, Wang S, Xia Y, Liu J, He J, et al. Evaluation of immunocompatibility of tissue-engineered periosteum. Biomed Mater. 2011;6:015005 pubmed publisher
    Tissue-engineered periosteum (TEP) and 'intramembranous ossification' may be an alternative approach to bone tissue engineering...
  8. Fan W, Crawford R, Xiao Y. Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model. Biomaterials. 2010;31:3580-9 pubmed publisher
    The periosteum plays an indispensable role in both bone formation and bone defect healing...
  9. Becker S, Douglas T, Acil Y, Seitz H, Sivananthan S, Wiltfang J, et al. Biocompatibility of individually designed scaffolds with human periosteum for use in tissue engineering. J Mater Sci Mater Med. 2010;21:1255-62 pubmed publisher
    ..Human periosteum cells were cultured using an osteogenic medium consisting of Dulbecco's modified Eagle medium supplemented with ..
  10. Zhao L, Zhao J, Wang S, Wang J, Liu J. Comparative study between tissue-engineered periosteum and structural allograft in rabbit critical-sized radial defect model. J Biomed Mater Res B Appl Biomater. 2011;97:1-9 pubmed publisher
    The purpose of this study was to compare the efficacy of tissue-engineered periosteum (TEP) to allgeneic bone in repairing segmental bone defect...
  11. Paulo A, Castro Silva I, Oliveira D, Machado M, Bonetti Filho I, Granjeiro J. Repair of critical-size defects with autogenous periosteum-derived cells combined with bovine anorganic apatite/collagen: an experimental study in rat calvaria. Braz Dent J. 2011;22:322-8 pubmed
    The aim of this study was to evaluate the bone repair using autogenous periosteum-derived cells (PDC) and bovine anorganic apatite and collagen (HA-COL)...
  12. Castro Silva I, Zambuzzi W, de Oliveira Castro L, Granjeiro J. Periosteal-derived cells for bone bioengineering: a promising candidate. Clin Oral Implants Res. 2012;23:1238-42 pubmed publisher
    ..Among them, periosteum tissue has emerged as an interesting candidate...
  13. Li H, Jiang J, Wu Y, Chen S. Potential mechanisms of a periosteum patch as an effective and favourable approach to enhance tendon-bone healing in the human body. Int Orthop. 2012;36:665-9 pubmed publisher
    ..b>Periosteum, a favourable autologous tissue, was confirmed to be effective in promoting tendon-bone healing in the human ..
  14. Evans S, Parent J, Lasko C, Zhen X, Knothe U, Lemaire T, et al. Periosteum, bone's "smart" bounding membrane, exhibits direction-dependent permeability. J Bone Miner Res. 2013;28:608-17 pubmed publisher
    The periosteum serves as bone's bounding membrane, exhibits hallmarks of semipermeable epithelial barrier membranes, and contains mechanically sensitive progenitor cells capable of generating bone...
  15. Evans S, Docheva D, Bernecker A, Colnot C, Richter R, Knothe Tate M. Solid-supported lipid bilayers to drive stem cell fate and tissue architecture using periosteum derived progenitor cells. Biomaterials. 2013;34:1878-87 pubmed publisher
    ..These studies demonstrate a biosynthetic in vitro cell culture platform to elucidate and guide emergent tissue architectures by PDCs...
  16. Chang H, Knothe Tate M. Concise review: the periosteum: tapping into a reservoir of clinically useful progenitor cells. Stem Cells Transl Med. 2012;1:480-91 pubmed publisher
    Elucidation of the periosteum and its regenerative potential has become a hot topic in orthopedics...
  17. Yu Y, Lieu S, Lu C, Colnot C. Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair. Bone. 2010;47:65-73 pubmed publisher
    ..Specifically, the periosteum was found to be a target of exogenous BMP2 as shown by activation of the BMP pathway in this tissue...
  18. Wang Q, Huang C, Xue M, Zhang X. Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing. Bone. 2011;48:524-32 pubmed publisher
    ..To gain a better understanding of the role of BMP-2 in periosteum-mediated bone repair, we deleted BMP-2 postnatally at the initiation stage of healing utilizing a Tamoxifen-..
  19. Al Qtaitat A, Shore R, Aaron J. Structural changes in the ageing periosteum using collagen III immuno-staining and chromium labelling as indicators. J Musculoskelet Neuronal Interact. 2010;10:112-23 pubmed
    The periosteum and Sharpey's fibre extensions occupy the musculoskeletal interface and may be strategic in age-related deterioration...
  20. Ma Y, Marin F, Stepan J, Ish Shalom S, Möricke R, Hawkins F, et al. Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis. Bone. 2011;48:972-8 pubmed publisher
    The periosteum contains osteogenic cells that regulate the outer shape of bone and contribute to determine its cortical thickness, size and position...
  21. McBride S, Dolejs S, Brianza S, Knothe U, Knothe Tate M. Net change in periosteal strain during stance shift loading after surgery correlates to rapid de novo bone generation in critically sized defects. Ann Biomed Eng. 2011;39:1570-81 pubmed publisher
    In an ovine femur model, proliferative woven bone fills critically sized defects enveloped by periosteum within 2 weeks of treatment with the one-stage bone-transport surgery. We hypothesize that mechanical loading modulates this process...
  22. Vegas M, Delgado P, Roger I, Carosini R. Vascularized periosteal transfer from the medial femoral condyle: is it compulsory to include the cortical bone?. J Trauma Acute Care Surg. 2012;72:1040-5 pubmed publisher
    ..medial femoral condyle has become the workhorse in the management of recalcitrant nonunions with vascularized periosteum. Inclusion of the outer condylar cortex has been advocated to avoid damaging the osteogenic capacity of the ..
  23. Chen C, Chang C, Wang K, Su C, Liu H, Yu C, et al. Enhancement of rotator cuff tendon-bone healing with injectable periosteum progenitor cells-BMP-2 hydrogel in vivo. Knee Surg Sports Traumatol Arthrosc. 2011;19:1597-607 pubmed publisher
  24. McBride S, Evans S, Knothe Tate M. Anisotropic mechanical properties of ovine femoral periosteum and the effects of cryopreservation. J Biomech. 2011;44:1954-9 pubmed publisher
    The mechanical properties of periosteum are not well characterized...
  25. Limpaphayom N, Prasongchin P. Surgical technique: Lower limb-length equalization by periosteal stripping and periosteal division. Clin Orthop Relat Res. 2011;469:3181-9 pubmed publisher
    ..Periosteal stripping and/or division (PSPD) have been studied in animal models and in humans with encouraging results. We combined these procedures and used it to equalize lower limb length...
  26. Alexander D, Schäfer F, Olbrich M, Friedrich B, Buhring H, Hoffmann J, et al. MSCA-1/TNAP selection of human jaw periosteal cells improves their mineralization capacity. Cell Physiol Biochem. 2010;26:1073-80 pubmed publisher
    Human jaw periosteum-derived cells (JPCs) represent an alternative cell source to bone marrow-derived mesenchymal stem cells for tissue engineering applications in the oral and maxillofacial surgery...
  27. Colnot C, Zhang X, Knothe Tate M. Current insights on the regenerative potential of the periosteum: molecular, cellular, and endogenous engineering approaches. J Orthop Res. 2012;30:1869-78 pubmed publisher
    While century old clinical reports document the periosteum's remarkable regenerative capacity, only in the past decade have scientists undertaken mechanistic investigations of its regenerative potential...
  28. Kisiel A, McDuffee L, Masaoud E, Bailey T, Esparza Gonzalez B, Niño Fong R. Isolation, characterization, and in vitro proliferation of canine mesenchymal stem cells derived from bone marrow, adipose tissue, muscle, and periosteum. Am J Vet Res. 2012;73:1305-17 pubmed publisher
    To isolate and characterize mesenchymal stem cells (MSCs) from canine muscle and periosteum and compare proliferative capacities of bone marrow-, adipose tissue-, muscle-, and periosteum-derived MSCs (BMSCs, AMSCs, MMSCs, and PMSCs, ..
  29. Chen D, Shen H, Shao J, Jiang Y, Lu J, He Y, et al. Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. Int J Mol Med. 2011;27:707-13 pubmed publisher
    ..An alternative source of MSCs is the periosteum-derived cells, and these cells appear to be easy to harvest and expand ex vivo...
  30. Alexander D, Ardjomandi N, Munz A, Friedrich B, Reinert S. ECM remodelling components regulated during jaw periosteal cell osteogenesis. Cell Biol Int. 2011;35:973-80 pubmed publisher
    ..In summary, we identified new collagen types and TIMPs that seem to play important roles during the osteogenesis of jaw periosteal progenitor cells...
  31. Yang W, Guo D, Harris M, Cui Y, Gluhak Heinrich J, Wu J, et al. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci. 2013;126:4085-98 pubmed publisher
    ..Bmp2 in osteoblasts also indirectly controls angiogenesis in the periosteum and bone marrow. VegfA production is reduced in Bmp2-cKO(ob) osteoblasts...
  32. Matsushima S, Isogai N, Jacquet R, Lowder E, Tokui T, Landis W. The nature and role of periosteum in bone and cartilage regeneration. Cells Tissues Organs. 2011;194:320-5 pubmed publisher
    This study was undertaken to determine whether periosteum from different bone sources in a donor results in the same formation of bone and cartilage...
  33. Evans S, Chang H, Knothe Tate M. Elucidating multiscale periosteal mechanobiology: a key to unlocking the smart properties and regenerative capacity of the periosteum?. Tissue Eng Part B Rev. 2013;19:147-59 pubmed publisher
    The periosteum, a thin, fibrous tissue layer covering most bones, resides in a dynamic, mechanically loaded environment. The periosteum also provides a niche for mesenchymal stem cells...
  34. Kock L, Ravetto A, van Donkelaar C, Foolen J, Emans P, Ito K. Tuning the differentiation of periosteum-derived cartilage using biochemical and mechanical stimulations. Osteoarthritis Cartilage. 2010;18:1528-35 pubmed publisher
    In this study, we aim at tuning the differentiation of periosteum in an organ culture model towards cartilage, rich in collagen type II, using combinations of biochemical and mechanical stimuli...
  35. Fan W, Bouwense S, Crawford R, Xiao Y. Structural and cellular features in metaphyseal and diaphyseal periosteum of osteoporotic rats. J Mol Histol. 2010;41:51-60 pubmed publisher
    Despite the important physiological role of periosteum in the pathogenesis and treatment of osteoporosis, little is known about the structural and cellular characteristics of periosteum in osteoporosis...
  36. Sato K, Haruyama N, Shimizu Y, Hara J, Kawamura H. Osteogenesis by gradually expanding the interface between bone surface and periosteum enhanced by bone marrow stem cell administration in rabbits. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:32-40 pubmed publisher
    ..We investigated whether administration of mesenchymal stem cells (MSCs) promotes bone formation at the gap created by periosteal distraction...
  37. Ribeiro F, Suaid F, Ruiz K, Rodrigues T, Carvalho M, Nociti F, et al. Peri-implant reconstruction using autologous periosteum-derived cells and guided bone regeneration. J Clin Periodontol. 2010;37:1128-36 pubmed publisher
    This investigation evaluated the bone healing in peri-implant defects treated with periosteum-derived cells (PCs) and guided bone regeneration (GBR).
  38. Guo H, Li X, Yuan X, Ma X. Reconstruction of radial bone defects using the reinforced tissue-engineered periosteum: an experimental study on rabbit weightbearing segment. J Trauma Acute Care Surg. 2012;72:E94-100 pubmed
    The objective of this study was to compare the osteogenic potential of reinforced and conventional tissue-engineered periosteum.
  39. Jimenez Andrade J, Mantyh W, Bloom A, Xu H, Ferng A, Dussor G, et al. A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Bone. 2010;46:306-13 pubmed publisher
    ..fibers that innervate the glabrous skin of the hindpaw as compared to the bone marrow, mineralized bone and periosteum of the femur...
  40. Bullens P, Schreuder H, de Waal Malefijt M, Verdonschot N, Buma P. The presence of periosteum is essential for the healing of large diaphyseal segmental bone defects reconstructed with trabecular metal: a study in the femur of goats. J Biomed Mater Res B Appl Biomater. 2010;92:24-31 pubmed publisher
    ..be used to reconstruct large load bearing segmental diaphyseal bone defects in the presence or absence of a periosteum coverage...
  41. Parfitt A. Size of bone in the aged endocortical resorption. J Bone Miner Res. 2002;17:1306; author reply 1307-8 pubmed
  42. Hermanns Sachweh B, Senderek J, Alfer J, Klosterhalfen B, Buttner R, Fuzesi L, et al. Vascular changes in the periosteum of congenital pseudarthrosis of the tibia. Pathol Res Pract. 2005;201:305-12 pubmed
    ..The most striking finding in all patients was thickened periosteum with accumulation of nerval cells surrounding small arteries, causing subtotal or complete obliteration...
  43. Knothe Tate M, Ritzman T, Schneider E, Knothe U. Testing of a new one-stage bone-transport surgical procedure exploiting the periosteum for the repair of long-bone defects. J Bone Joint Surg Am. 2007;89:307-16 pubmed
    ..A recently proposed one-stage bone-transport surgical procedure exploits the intrinsic osteogenic potential of the periosteum while providing mechanical stability through intramedullary nailing...
  44. Spitzer R, Perka C, Lindenhayn K, Zippel H. Matrix engineering for osteogenic differentiation of rabbit periosteal cells using alpha-tricalcium phosphate particles in a three-dimensional fibrin culture. J Biomed Mater Res. 2002;59:690-6 pubmed
    ..After cell isolation from tibial periosteum of New Zealand White rabbits, and following monolayer culture, cells were embedded in alginate-fibrin beads ..
  45. Seeman E. The periosteum--a surface for all seasons. Osteoporos Int. 2007;18:123-8 pubmed
  46. Yamamiya K, Okuda K, Kawase T, Hata K, Wolff L, Yoshie H. Tissue-engineered cultured periosteum used with platelet-rich plasma and hydroxyapatite in treating human osseous defects. J Periodontol. 2008;79:811-8 pubmed
    The aim of the present controlled clinical study was to compare the clinical response of human cultured periosteum (HCP) sheets in combination with platelet-rich plasma (PRP) and porous hydroxyapatite (HA) granules to a mixture of PRP and ..
  47. Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, et al. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem. 2010;285:2028-39 pubmed publisher
    ..This study suggests a role for periostin in adaptation of the ECM architecture in the mechanical environment...
  48. Stich S, Loch A, Leinhase I, Neumann K, Kaps C, Sittinger M, et al. Human periosteum-derived progenitor cells express distinct chemokine receptors and migrate upon stimulation with CCL2, CCL25, CXCL8, CXCL12, and CXCL13. Eur J Cell Biol. 2008;87:365-76 pubmed publisher
    ..PCs were isolated from periosteum of the mastoid bone and displayed a homogenous cell population presenting an MSC-related cell-surface antigen ..
  49. Hayashi O, Katsube Y, Hirose M, Ohgushi H, Ito H. Comparison of osteogenic ability of rat mesenchymal stem cells from bone marrow, periosteum, and adipose tissue. Calcif Tissue Int. 2008;82:238-47 pubmed publisher
    ..this study was to compare the osteogenic differentiation capability of MSCs from bone marrow (BMSCs), MSCs from periosteum (PMSCs), and AMSCs using in vitro culture and in vivo implantation experiments...
  50. De Bari C, Dell accio F, Vanlauwe J, Eyckmans J, Khan I, Archer C, et al. Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis. Arthritis Rheum. 2006;54:1209-21 pubmed
    ..To investigate whether periosteal cells from adult humans have features of multipotent mesenchymal stem cells (MSCs) at the single-cell level...
  51. Kanou M, Ueno T, Kagawa T, Fujii T, Sakata Y, Ishida N, et al. Osteogenic potential of primed periosteum graft in the rat calvarial model. Ann Plast Surg. 2005;54:71-8 pubmed
    ..Based on modern concepts of tissue engineering, periosteum has gained attention as a suitable osteogenic material...
  52. Li C, Suttie J. Tissue collection methods for antler research. Eur J Morphol. 2003;41:23-30 pubmed
    ..For sampling stem tissue, entire initial antlerogenic periosteum (around 22 mm in diameter) could be readily peeled off from the underlying bone using a pair of rat-toothed ..
  53. Midura R, Su X, Morcuende J, Tammi M, Tammi R. Parathyroid hormone rapidly stimulates hyaluronan synthesis by periosteal osteoblasts in the tibial diaphysis of the growing rat. J Biol Chem. 2003;278:51462-8 pubmed
    ..PTH increased the overall HyA content of periosteum 5-fold, with the basal cambium layer exhibiting the greatest enhancement ( approximately 8-fold)...
  54. Sharma P, Gogoi M, Kedar S, Bhola R. Periosteal fixation in third-nerve palsy. J AAPOS. 2006;10:324-7 pubmed
    We present a new technique of anchoring the eyeball to the nasal periosteum using a nonabsorbable suture in acquired isolated third-nerve paresis.
  55. Jansen E, Emans P, Guldemond N, van Rhijn L, Welting T, Bulstra S, et al. Human periosteum-derived cells from elderly patients as a source for cartilage tissue engineering?. J Tissue Eng Regen Med. 2008;2:331-9 pubmed publisher
    The aim of this study was to establish the potential of human periosteum-derived cells from elderly patients as a cell source for cartilage tissue engineering by optimizing culture conditions for both proliferation and differentiation...
  56. Hattori K, Yoshikawa T, Takakura Y, Aoki H, Sonobe M, Tomita N. Bio-artificial periosteum for severe open fracture--an experimental study of osteogenic cell/collagen sponge composite as a bio-artificial periosteum. Biomed Mater Eng. 2005;15:127-36 pubmed
    In an attempt to reduce complications in cases of severe open fracture, we developed a bio-artificial periosteum composed of osteogenic cells and collagen sponge...
  57. Jilka R, O Brien C, Ali A, Roberson P, Weinstein R, Manolagas S. Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts. Bone. 2009;44:275-86 pubmed publisher
    ..that daily injections of 100 ng/g of PTH(1-34) to 4-6 month old mice increased the number of osteoblasts on the periosteum of lumbar vertebrae by 2-3 fold as early as after 2 days...
  58. Hutmacher D, Sittinger M. Periosteal cells in bone tissue engineering. Tissue Eng. 2003;9 Suppl 1:S45-64 pubmed
    In 1742, H.L. Duhamel published a report in which the osteogenic function of periosteum was described. In 1932 H.B...
  59. Ueno T, Kagawa T, Fukunaga J, Mizukawa N, Kanou M, Fujii T, et al. Regeneration of the mandibular head from grafted periosteum. Ann Plast Surg. 2003;51:77-83 pubmed
    Grafted periosteum has a rich potential to induce heterotopic bone formation. In the current study the authors investigate whether autogenous periosteal grafts can regenerate the mandibular head in a rabbit model...
  60. Szulc P, Seeman E. Thinking inside and outside the envelopes of bone: dedicated to PDD. Osteoporos Int. 2009;20:1281-8 pubmed publisher
    ..Bone is distributed and redistributed to achieve strength commensurate with its loading requirements...
  61. Allen M, Burr D. Human femoral neck has less cellular periosteum, and more mineralized periosteum, than femoral diaphyseal bone. Bone. 2005;36:311-6 pubmed
    Periosteal expansion enhances bone strength and is controlled by osteogenic cells of the periosteum. The extent of cellular periosteum at the human femoral neck, a clinically relevant site, is unclear...
  62. Beniker D, McQuillan D, Livesey S, Urban R, Turner T, Blum B, et al. The use of acellular dermal matrix as a scaffold for periosteum replacement. Orthopedics. 2003;26:s591-6 pubmed
    Three preclinical models were used to evaluate GraftJacket Acellular Periosteum Replacement Scaffold (Wright Medical Technology, Inc, Arlington, Tenn)...