methazolamide

Summary

Summary: A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Top Publications

  1. Nolan J, Gathright C, Radvany C, Barrett R, Sancilio L. Carbonic anhydrase inhibitors are antiarthritic in the rat. Pharmacol Res. 1991;24:377-83 pubmed
    ..Acetazolamide, ethoxzolamide, methazolamide, and dichlorphenamide reduced paw oedema and attenuated the deterioration of the joints of rats with adjuvant ..
  2. Kim S, Kim M, Lee K, Kim S, Kang H, Park H, et al. HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. Pharmacogenomics. 2010;11:879-84 pubmed publisher
    The carbonic anhydrase inhibitor methazolamide infrequently causes Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports...
  3. Hirono C, Nakamoto T, Sugita M, Iwasa Y, Akagawa Y, Shiba Y. Gramicidin-perforated patch analysis on HCO3- secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells. J Membr Biol. 2001;180:11-9 pubmed
    ..The anion current was markedly suppressed by addition of 1 mM methazolamide, a carbonic anhydrase inhibitor, and removal of external HCO3-...
  4. Muenter M, Daube J, Caviness J, Miller P. Treatment of essential tremor with methazolamide. Mayo Clin Proc. 1991;66:991-7 pubmed
    We treated 28 patients (16 women and 12 men) who had essential tremor with methazolamide. Their median age was 69 years (range, 34 to 89 years), and the median duration of tremor was 16 years (range, less than 1 to 69 years)...
  5. Konstantopoulos N, Molero J, McGee S, Spolding B, Connor T, De Vries M, et al. Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo. Diabetes. 2012;61:2146-54 pubmed publisher
    We previously used Gene Expression Signature technology to identify methazolamide (MTZ) and related compounds with insulin sensitizing activity in vitro...
  6. Shirato S, Kagaya F, Suzuki Y, Joukou S. Stevens-Johnson syndrome induced by methazolamide treatment. Arch Ophthalmol. 1997;115:550-3 pubmed
    Four cases of Stevens-Johnson syndrome considered to be induced by methazolamide were reported. In all of the cases, the first signs of Stevens-Johnson syndrome (i.e...
  7. Gudmundsdottir E, Stefansson E, Bjarnadottir G, Sigurjonsdottir J, Gudmundsdottir G, Masson M, et al. Methazolamide 1% in cyclodextrin solution lowers IOP in human ocular hypertension. Invest Ophthalmol Vis Sci. 2000;41:3552-4 pubmed
    To formulate aqueous eye drops containing methazolamide 1% in cyclodextrin solution and to evaluate their effect on intraocular pressure (IOP) in a double-blind randomized trial in humans...
  8. Bijl J, Mousavi Gourabi B, Dahan A, Teppema L. Effects of low-dose methazolamide on the control of breathing in cats. Adv Exp Med Biol. 2006;580:257-62; discussion 351-9 pubmed
  9. Wang X, Figueroa B, Stavrovskaya I, Zhang Y, Sirianni A, Zhu S, et al. Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. Stroke. 2009;40:1877-85 pubmed publisher
    ..We demonstrate that methazolamide and melatonin are protective in cellular and in vivo models of neuronal hypoxia...
  10. Qian Y, Wang F, Li R, Zhang Q, Xu Q. Preparation and evaluation of in situ gelling ophthalmic drug delivery system for methazolamide. Drug Dev Ind Pharm. 2010;36:1340-7 pubmed publisher
    ..in situ gelling vehicle was prepared to increase the precorneal resident time and the bioavailability of methazolamide (MTA)...

Detail Information

Publications93

  1. Nolan J, Gathright C, Radvany C, Barrett R, Sancilio L. Carbonic anhydrase inhibitors are antiarthritic in the rat. Pharmacol Res. 1991;24:377-83 pubmed
    ..Acetazolamide, ethoxzolamide, methazolamide, and dichlorphenamide reduced paw oedema and attenuated the deterioration of the joints of rats with adjuvant ..
  2. Kim S, Kim M, Lee K, Kim S, Kang H, Park H, et al. HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. Pharmacogenomics. 2010;11:879-84 pubmed publisher
    The carbonic anhydrase inhibitor methazolamide infrequently causes Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports...
  3. Hirono C, Nakamoto T, Sugita M, Iwasa Y, Akagawa Y, Shiba Y. Gramicidin-perforated patch analysis on HCO3- secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells. J Membr Biol. 2001;180:11-9 pubmed
    ..The anion current was markedly suppressed by addition of 1 mM methazolamide, a carbonic anhydrase inhibitor, and removal of external HCO3-...
  4. Muenter M, Daube J, Caviness J, Miller P. Treatment of essential tremor with methazolamide. Mayo Clin Proc. 1991;66:991-7 pubmed
    We treated 28 patients (16 women and 12 men) who had essential tremor with methazolamide. Their median age was 69 years (range, 34 to 89 years), and the median duration of tremor was 16 years (range, less than 1 to 69 years)...
  5. Konstantopoulos N, Molero J, McGee S, Spolding B, Connor T, De Vries M, et al. Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo. Diabetes. 2012;61:2146-54 pubmed publisher
    We previously used Gene Expression Signature technology to identify methazolamide (MTZ) and related compounds with insulin sensitizing activity in vitro...
  6. Shirato S, Kagaya F, Suzuki Y, Joukou S. Stevens-Johnson syndrome induced by methazolamide treatment. Arch Ophthalmol. 1997;115:550-3 pubmed
    Four cases of Stevens-Johnson syndrome considered to be induced by methazolamide were reported. In all of the cases, the first signs of Stevens-Johnson syndrome (i.e...
  7. Gudmundsdottir E, Stefansson E, Bjarnadottir G, Sigurjonsdottir J, Gudmundsdottir G, Masson M, et al. Methazolamide 1% in cyclodextrin solution lowers IOP in human ocular hypertension. Invest Ophthalmol Vis Sci. 2000;41:3552-4 pubmed
    To formulate aqueous eye drops containing methazolamide 1% in cyclodextrin solution and to evaluate their effect on intraocular pressure (IOP) in a double-blind randomized trial in humans...
  8. Bijl J, Mousavi Gourabi B, Dahan A, Teppema L. Effects of low-dose methazolamide on the control of breathing in cats. Adv Exp Med Biol. 2006;580:257-62; discussion 351-9 pubmed
  9. Wang X, Figueroa B, Stavrovskaya I, Zhang Y, Sirianni A, Zhu S, et al. Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. Stroke. 2009;40:1877-85 pubmed publisher
    ..We demonstrate that methazolamide and melatonin are protective in cellular and in vivo models of neuronal hypoxia...
  10. Qian Y, Wang F, Li R, Zhang Q, Xu Q. Preparation and evaluation of in situ gelling ophthalmic drug delivery system for methazolamide. Drug Dev Ind Pharm. 2010;36:1340-7 pubmed publisher
    ..in situ gelling vehicle was prepared to increase the precorneal resident time and the bioavailability of methazolamide (MTA)...
  11. Li R, Jiang S, Liu D, Bi X, Wang F, Zhang Q, et al. A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide. J Microencapsul. 2011;28:134-41 pubmed publisher
    b>Methazolamide (MTA) is an antiglaucoma drug; however, there are many side effects of its systemic administration with insufficient ocular therapeutic concentrations...
  12. Chang X, Yan X, Zhang Y. Treat ankylosing spondylitis with methazolamide. Int J Med Sci. 2011;8:413-9 pubmed
    ..This study aimed to evaluate the effectiveness and safety of methazolamide, an anti-carbonic anhydrase drug, for treating patients with AS...
  13. Youshia J, Kamel A, El Shamy A, Mansour S. Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide. Int J Nanomedicine. 2012;7:2483-96 pubmed publisher
    ..This study assessed the feasibility of using nanostructured lipid matrices (NLMs) for ocular delivery of methazolamide-(MZA) adopting heterolipids composed of novel mixtures of Compritol (®) and cetostearyl alcohol (CSA), and ..
  14. Fishman G, Gilbert L, Anderson R, Marmor M, Weleber R, Viana M. Effect of methazolamide on chronic macular edema in patients with retinitis pigmentosa. Ophthalmology. 1994;101:687-93 pubmed
    To determine the effectiveness of methazolamide for improving visual acuity and macular edema in patients with retinitis pigmentosa...
  15. Shimoda L, Luke T, Sylvester J, Shih H, Jain A, Swenson E. Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1002-12 pubmed
    ..These results suggest that AZ attenuates HPV by selectively inhibiting hypoxia-induced Ca2+ responses via a mechanism independent of CA inhibition, changes in pH(i), or membrane potential. ..
  16. Busenbark K, Pahwa R, Hubble J, Hopfensperger K, Koller W, Pogrebra K. Double-blind controlled study of methazolamide in the treatment of essential tremor. Neurology. 1993;43:1045-7 pubmed
    We studied the effect of the carbonic anhydrase inhibitor methazolamide in 25 patients with essential tremor (ET) in a double-blind, placebo-controlled trial...
  17. Kwon S, Park D, Shin J. Bilateral transient myopia, angle-closure glaucoma, and choroidal detachment induced by methazolamide. Jpn J Ophthalmol. 2012;56:515-7 pubmed publisher
    ..myopia, secondary angle-closure glaucoma, and choroidal detachment associated with oral administration of methazolamide. A 51-year-old man developed bilateral transient myopia and secondary angle-closure glaucoma with choroidal ..
  18. Chen R, Qian Y, Li R, Zhang Q, Liu D, Wang M, et al. Methazolamide calcium phosphate nanoparticles in an ocular delivery system. Yakugaku Zasshi. 2010;130:419-24 pubmed
    A new system for the local delivery of methazolamide to the eye has been developed based on calcium phosphate (CaP) nanoparticles...
  19. Cote C, Riverin H, Barras M, Tremblay R, Fremont P, Frenette J. Effect of carbonic anhydrase III inhibition on substrate utilization and fatigue in rat soleus. Can J Physiol Pharmacol. 1993;71:277-83 pubmed
    ..Rat soleus muscles were incubated in vitro in a physiological solution with or without CA inhibitor (methazolamide, 1 mM) and submitted to a fatigue protocol...
  20. Sjöblom M, Singh A, Zheng W, Wang J, Tuo B, Krabbenhöft A, et al. Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci U S A. 2009;106:13094-9 pubmed publisher
    ..The complete inhibition of tissue CAs by luminal methazolamide and i.v...
  21. Borgula G, Karwoski C, Steinberg R. Light-evoked changes in extracellular pH in frog retina. Vision Res. 1989;29:1069-77 pubmed
    ..Inhibition of carbonic anhydrase (CA) with acetazolamide or methazolamide increased both the proximal and distal retinal delta pH0, suggesting that CA is involved in buffering retinal ..
  22. Fremont P, Riverin H, Frenette J, Rogers P, Cote C. Fatigue and recovery of rat soleus muscle are influenced by inhibition of an intracellular carbonic anhydrase isoform. Am J Physiol. 1991;260:R615-21 pubmed
    ..2.1.1) is the most abundant cytosolic enzyme in type I skeletal muscle fibers. Methazolamide, a specific CA inhibitor, was used to characterize the effects of inhibiting CA III on the resistance to ..
  23. Mizumori M, Meyerowitz J, Takeuchi T, Lim S, Lee P, Supuran C, et al. Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa. J Physiol. 2006;573:827-42 pubmed
    ..Rat duodena were perfused with solutions of different pH and PCO2 with or without a cell-permeant CA inhibitor methazolamide (MTZ) or impermeant CA inhibitors...
  24. Cincinelli A, Martellini T, Vullo D, Supuran C. Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus. Bioorg Med Chem Lett. 2015;25:5485-9 pubmed publisher
    ..Many clinically used drugs, such as acetazolamide, methazolamide, dorzolamide, brinzolamide, topiramate and benzolamide were low nanomolar inhibitors, with KIs in the range of ..
  25. Goldfarb D, Sly W, Waheed A, Charney A. Acid-base effects on electrolyte transport in CA II-deficient mouse colon. Am J Physiol Gastrointest Liver Physiol. 2000;278:G409-15 pubmed
    ..Membrane-permeant methazolamide, but not impermeant benzolamide, at 0.1 mM prevented the effects of pH...
  26. Garvin J, Spring K, Santi P. Secretion of endolymph by semicircular canals of the shark. Am J Physiol. 1988;255:F711-9 pubmed
    ..Fluid secretion was dependent on active transport and was inhibited by ouabain, bumetanide, or methazolamide in the external bathing solution...
  27. Gende O. Functional interaction of carbonic anhydrase and chloride/bicarbonate exchange in human platelets. Platelets. 2005;16:392-7 pubmed
    ..study shows that the efflux of HC was slower when the platelets were previously incubated in 100 microM methazolamide. As a conclusion, the recovery of pHi from alkalosis by Na-independent Cl-/HC exchange is facilitated in ..
  28. Francis S, Taylor Wells J, Gross A, Bloomquist J. Toxicity and Physiological Actions of Carbonic Anhydrase Inhibitors to Aedes aegypti and Drosophila melanogaster. Insects. 2016;8: pubmed publisher
    ..The 24 h larvicidal toxicities followed this rank order of potency: dichlorphenamide > methazolamide > acetazolamide = brinzolamide = dorzolamide...
  29. Iturriaga R. Carotid body chemoreception: the importance of CO2-HCO3- and carbonic anhydrase. (review). Biol Res. 1993;26:319-29 pubmed
    ..This role is likely to be related to the ion exchanger function and then to pHi regulation in the chemoreceptor cells. ..
  30. Vessey J, Stratis A, Daniels B, Da Silva N, Jonz M, Lalonde M, et al. Proton-mediated feedback inhibition of presynaptic calcium channels at the cone photoreceptor synapse. J Neurosci. 2005;25:4108-17 pubmed
    ..Voltage clamp of isolated HCs revealed an amiloride-sensitive conductance that could mediate modulation of cleft pH dependent on the membrane potential of these postsynaptic cells. ..
  31. Goldfarb D, Chan A, Hernandez D, Charney A. Effect of thiazides on colonic NaCl absorption: role of carbonic anhydrase. Am J Physiol. 1991;261:F452-8 pubmed
    ..Prior exposure of the colon to the carbonic anhydrase inhibitor methazolamide (0...
  32. Kishida K, Saida N, Yamamura N, Iwai Y, Sasabe T. Cysteine conjugate of methazolamide is metabolized by beta-lyase. J Pharm Sci. 2001;90:224-33 pubmed
    Bovine kidney and liver homogenates degraded a cysteine conjugate of methazolamide, S-(5-acetylimino-4-methyl-Delta2-1,3,4-thiadiazolin-2-yl)cysteine...
  33. Nakamoto T, Shiba Y, Hirono C, Sugita M, Takemoto K, Iwasa Y, et al. Carbachol-induced fluid movement through methazolamide-sensitive bicarbonate production in rat parotid intralobular ducts: quantitative analysis of fluorescence images using fluorescent dye sulforhodamine under a confocal laser scanning microscope. Eur J Cell Biol. 2002;81:497-504 pubmed
    ..clearance of the fluorescent dye was divided into two phases by the sensitivity to external Ca2+ and methazolamide, an inhibitor for carbonic anhydrase...
  34. Tanimura Y, Hiroaki Y, Fujiyoshi Y. Acetazolamide reversibly inhibits water conduction by aquaporin-4. J Struct Biol. 2009;166:16-21 pubmed publisher
    ..b>Methazolamide (MZA), another sulfonamide CA inhibitor similar in chemical structure to AZA, shows no significant effect on ..
  35. Chakravarty S, Kannan K. Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme. J Mol Biol. 1994;243:298-309 pubmed
    ..and active site residues His200 and His67 amongst others in the native enzyme, is disrupted upon binding of methazolamide but not in the other two sulfonamides...
  36. Bell H, Haouzi P. The hypoxia-induced facilitation of augmented breaths is suppressed by the common effect of carbonic anhydrase inhibition. Respir Physiol Neurobiol. 2010;171:201-11 pubmed publisher
    ..addressed this question by studying the effects of treatment with an alternative carbonic anhydrase inhibitor, methazolamide, which has been reported to leave carotid body responsiveness to hypoxia intact...
  37. Akiba Y, Mizumori M, Kuo M, Ham M, Guth P, Engel E, et al. CO2 chemosensing in rat oesophagus. Gut. 2008;57:1654-64 pubmed publisher
    ..4 high CO(2) (P(CO2) = 260 Torr) solutions with or without the cell-permeant carbonic anhydrase (CA) inhibitor methazolamide (MTZ, 1 mM), the cell-impermeant CA inhibitor benzolamide (BNZ, 0...
  38. Iturriaga R, Mokashi A, Lahiri S. Anion exchanger and chloride channel in cat carotid body chemotransduction. J Auton Nerv Syst. 1998;70:23-31 pubmed
    ..effects of the anion channel blocker anthracene-9-carboxylic acid (9-ANC), the carbonic anhydrase inhibitor methazolamide, and the HCO3-/Cl- exchanger blocker 4,4 diisothiocyanatostilbene-2-2'disulfonic acid (DIDS) on the ..
  39. Lichter P, Musch D, Medzihradsky F, Standardi C. Intraocular pressure effects of carbonic anhydrase inhibitors in primary open-angle glaucoma. Am J Ophthalmol. 1989;107:11-7 pubmed
    ..Preparations tested included acetazolamide tablets, acetazolamide Sequels, and methazolamide tablets...
  40. Pierce W, Nardin G, Fuqua M, Sabah Maren E, Stern S. Effect of chronic carbonic anhydrase inhibitor therapy on bone mineral density in white women. J Bone Miner Res. 1991;6:347-54 pubmed
    ..glaucoma subjects who were chronic users of the carbonic anhydrase (CA) inhibitors acetazolamide (Az) or methazolamide (Mz)...
  41. Tricarico D, Mele A, Calzolaro S, Cannone G, Camerino G, Dinardo M, et al. Emerging role of calcium-activated potassium channel in the regulation of cell viability following potassium ions challenge in HEK293 cells and pharmacological modulation. PLoS ONE. 2013;8:e69551 pubmed publisher
    ..The BK channel openers(10(-11)-10(-3)M) were: acetazolamide(ACTZ), Dichlorphenamide(DCP), methazolamide(MTZ), bendroflumethiazide(BFT), ethoxzolamide(ETX), hydrochlorthiazide(HCT), quercetin(QUERC), resveratrol(..
  42. Vogh B, Godman D. Effects of inhibition of angiotensin converting enzyme and carbonic anhydrase on fluid production by ciliary process, choroid plexus, and pancreas. J Ocul Pharmacol. 1989;5:303-11 pubmed
  43. Candia O. A novel system to measure labelled CO2 and HCO3- fluxes across epithelia: corneal epithelium as model tissue. Exp Eye Res. 1996;63:137-49 pubmed
    ..These fluxes were independent of the presence of Cl- in the bathing solutions. The bilateral addition of methazolamide (10(-4) M) reduced both unidirectional fluxes to about 2.0 mu eq h-1 cm-2...
  44. Ferris K, Clark R, Coates E. Topical inhibition of nasal carbonic anhydrase affects the CO2 detection threshold in rats. Chem Senses. 2007;32:263-71 pubmed
    ..2) to determine the rats' CO(2) detection thresholds before and after nasal perfusion of mammalian Ringers or methazolamide, a CA inhibitor...
  45. Beal A. Mechanisms of fluid and ion secretion by the parotid gland of the kangaroo, Macropus rufus, assessed by administration of transport-inhibiting drugs. J Comp Physiol B. 1995;165:396-405 pubmed
    ..0% of that for equivalent pre-amiloride stimulation. Equipotent levels of amiloride and methazolamide given concurrently were no more effective at blocking flow and bicarbonate secretion than when given ..
  46. Beal A. The effect of carbonic anhydrase inhibitors on secretion by the parotid and mandibular glands of red kangaroos Macropus rufus. J Comp Physiol B. 1991;161:611-9 pubmed
    ..b>Methazolamide infusion caused similar changes in parotid secretion...
  47. Iturriaga R, Lahiri S, Mokashi A. Carbonic anhydrase and chemoreception in the cat carotid body. Am J Physiol. 1991;261:C565-73 pubmed
    ..on its carbonic anhydrase (CA) activity, we used an in vitro cat CB preparation and studied the effects of methazolamide, a permeable CA inhibitor (pK 7.3), on the chemosensory responses to CO2, O2, and nicotine...
  48. Chen J, Lecuona E, Briva A, Welch L, Sznajder J. Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia. Am J Respir Cell Mol Biol. 2008;38:32-7 pubmed
    ..Inhibition of CAII by acetazolamide or methazolamide delayed the decrease in the intracellular pH observed during hypercapnia in cultured AECI, AECII, and AECI-..
  49. Flach A, Smith R, Fraunfelder F. Stevens-Johnson syndrome associated with methazolamide treatment reported in two Japanese-American women. Ophthalmology. 1995;102:1677-80 pubmed
    ..This is the first report of this syndrome associated with methazolamide treatment. The association is reported in two Japanese-American women...
  50. Beal A. The effect of transport-blocking drugs on secretion of fluid and electrolytes by the mandibular gland of red kangaroos, Macropus rufus. Arch Oral Biol. 1997;42:705-16 pubmed
    ..b>Methazolamide (0...
  51. Fanous M, Challa P, Maren T. Comparison of intraocular pressure lowering by topical and systemic carbonic anhydrase inhibitors in the rabbit. J Ocul Pharmacol Ther. 1999;15:51-7 pubmed
    ..2 (n=6). MK-417 was instilled to the left eye with the right eye used as an untreated control. One hour later methazolamide was given intravenously at 10 mg/kg, a dose known to give full inhibition of the enzyme...
  52. Unwin R, Walter S, Giebisch G, Capasso G, Shirley D. Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000;98:481-8 pubmed
    In order to clarify the effects on sodium reabsorption in the loop of Henle of methazolamide (a carbonic anhydrase inhibitor), chlorothiazide and the loop diuretics frusemide and bumetanide, superficial loops were perfused in vivo in ..
  53. del Pilar Corena M, Fiedler M, VanEkeris L, Tu C, Silverman D, Linser P. Alkalization of larval mosquito midgut and the role of carbonic anhydrase in different species of mosquitoes. Comp Biochem Physiol C Toxicol Pharmacol. 2004;137:207-25 pubmed
    ..We also tested the effect of CA inhibitors such as methazolamide and acetazolamide in the alkalization of the midgut for these species...
  54. Charney A, Egnor R. NaCl absorption in the rabbit ileum. Effect of acid-base variables. Gastroenterology. 1991;100:403-9 pubmed
    ..1 mmol/L), or 4,4'-diisothiocyanostilbene-2,2'-disulfonate (1 mmol/L), or by the carbonic anhydrase inhibitor methazolamide (1 mmol/L)...
  55. Discala F, Belachgar F, Planelles G, Hulin P, Anagnostopoulos T. Barium- or quinine-induced depolarization activates K+, Na+ and cationic conductances in frog proximal tubular cells. J Physiol. 1992;448:525-37 pubmed
    ..1 mM-methazolamide, to inhibit the rheogenic Na(+)-HCO3-symport, and 1 microM-amiloride, to block Na+ conductance (GNa)...
  56. Coates E, Knuth S, Bartlett D. Laryngeal CO2 receptors: influence of systemic PCO2 and carbonic anhydrase inhibition. Respir Physiol. 1996;104:53-61 pubmed
    ..Carbonic anhydrase was inhibited, locally, by perfusing the upper airways with either acetazolamide or methazolamide (10(-2) M) or systemically, by injecting acetazolamide intravenously (5, 10, or 25 mg/kg)...
  57. Kiwull Schöne H, Li Y, Kiwull P, Teppema L. Methazolamide does not impair respiratory work performance in anesthetized rabbits. Am J Physiol Regul Integr Comp Physiol. 2009;297:R648-54 pubmed publisher
    ..Among others, the highly diffusible CA-inhibitor methazolamide differs from acetazolamide in that it fails to activate Ca(2+)-dependent potassium channels in skeletal ..
  58. Mackintosh J, Thomas D, Olive J, Chesner I, Knight R. The effect of altitude on tests of reaction time and alertness. Aviat Space Environ Med. 1988;59:246-8 pubmed
    ..The latter explanation is favoured because of reports by other workers of an increase in reaction time with altitude in the absence of AMS. ..
  59. Preisig P, Rector F. Role of Na+-H+ antiport in rat proximal tubule NaCl absorption. Am J Physiol. 1988;255:F461-5 pubmed
    ..b>Methazolamide (10(-4) M), a potent inhibitor of renal carbonic anhydrase, had no significant effect on either volume or ..
  60. Nguyen H, Donini A. Larvae of the midge Chironomus riparius possess two distinct mechanisms for ionoregulation in response to ion-poor conditions. Am J Physiol Regul Integr Comp Physiol. 2010;299:R762-73 pubmed publisher
    ..Inhibitors of the Na(+)/H(+) exchangers (EIPA) and carbonic anhydrase (methazolamide) provide evidence for Na(+)/H(+) and Cl(-)/HCO(3)(-) exchange mechanisms in the anal papillae...
  61. Cyr M, Laizure S, daCunha C. Methazolamide-induced delirium. Pharmacotherapy. 1997;17:387-9 pubmed
    A 74-year-old man became delirious 2 days after beginning oral therapy with methazolamide. The delirium was manifested by intermittent psychosis, incontinence of bowel and bladder, lethargy, and disorientation...
  62. Koo N, Kim Y. A case of paclitaxel-induced maculopathy treated with methazolamide. Korean J Ophthalmol. 2012;26:394-7 pubmed publisher
    ..is significant, replacing paclitaxel with another agent was not warranted; therefore, maintenance therapy with methazolamide was performed before and after administering the anti-cancer agent...
  63. Conroy C, Maren T. The ocular distribution of methazolamide after corneal and scleral administration: the effect of ionization state. J Ocul Pharmacol Ther. 1998;14:565-73 pubmed
    The accession of methazolamide in ionized and unionized form to cornea, sclera, aqueous humor and ciliary process was studied 10 minutes following separate application to either sclera or cornea of a 1 mM solution...
  64. Charney A, Egnor R, Henner D, Rashid H, Cassai N, Sidhu G. Acid-base effects on intestinal Cl- absorption and vesicular trafficking. Am J Physiol Cell Physiol. 2004;286:C1062-70 pubmed
    ..internalized when Pco(2) was reduced and exocytosed when Pco(2) was increased, and both mucosal wortmannin and methazolamide inhibited exocytosis...
  65. Suzuki Y, Kaneko K, Maruyama M, Hayashi H. Basolateral Cl-/HCO3- exchange in epithelial cells from guinea pig distal colon. Jpn J Physiol. 1994;44 Suppl 2:S305-7 pubmed
    ..These results suggest that HCO3- exit across the basolateral membrane is mediated by a DIDS-sensitive Cl-/HCO3- exchange. In addition, the lactic acid production appears to be coupled to the apical H+, K(+)-ATPase activity. ..
  66. Onken H, Moffett S, Moffett D. Alkalinization in the isolated and perfused anterior midgut of the larval mosquito, Aedes aegypti. J Insect Sci. 2008;8:1-20 pubmed publisher
    ..The carbonic anhydrase inhibitor, methazolamide (50 micromol l(-1)), on either the luminal or hemolymph-side, or the inhibitor of anion transport, DIDS (1 ..
  67. Gandham S, Spaeth G, Di Leonardo M, Costa V. Methazolamide-induced skin eruptions. Arch Ophthalmol. 1993;111:370-2 pubmed
    To our knowledge, this is the first histopathologic report of skin eruptions due to oral methazolamide. From the four cases studied, we conclude that there are at least two histopathologic types: one is characterized by perivascular ..
  68. Brugnara C, Van Ha T, Tosteson D. Role of chloride in potassium transport through a K-Cl cotransport system in human red blood cells. Am J Physiol. 1989;256:C994-1003 pubmed
    ..These data confirm that the volume-dependent Cl-dependent K movement in these cells operates through coupled K-Cl cotransport. ..
  69. Vogh B, Godman D, Maren T. Measurement of aqueous humor flow following scleral injection of sulfacetamide as marker: effect of methazolamide, timolol, and pilocarpine. J Ocul Pharmacol. 1989;5:293-302 pubmed
    ..37 S.E. overall. The data show that inhibition of carbonic anhydrase (CA) in ciliary processes by systemic methazolamide reduces flow 38%. Topical timolol reduces flow 35%...
  70. Schoenwald R, Deshpande G, Rethwisch D, Barfknecht C. Penetration into the anterior chamber via the conjunctival/scleral pathway. J Ocul Pharmacol Ther. 1997;13:41-59 pubmed
    ..A constant concentration of methazolamide analogs as well as 6-carboxyfluorescein (6-CB) and rhodamine B (RB) was maintained on either the cornea or the ..
  71. Iyer G, Taft D. Determination of methazolamide concentrations in human biological fluids using high performance liquid chromatography. J Pharm Biomed Anal. 1998;16:1021-7 pubmed
    b>Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma. In vivo, methazolamide readily distributes into red blood cells...
  72. Swenson E, Tewson T, Wistrand P, Ridderstrale Y, Tu C. Biochemical, histological, and inhibitor studies of membrane carbonic anhydrase in frog gastric acid secretion. Am J Physiol Gastrointest Liver Physiol. 2001;281:G61-8 pubmed
    ..isolated mucosa was measured before and after mucosal addition of a permeant CA inhibitor (methazolamide) and before and after mucosal or serosal addition of two impermeant CA inhibitors of differing molecular mass: ..
  73. Goldstein L, Brill S. Volume-activated taurine efflux from skate erythrocytes: possible band 3 involvement. Am J Physiol. 1991;260:R1014-20 pubmed
    ..Thus there is considerable evidence in favor of the involvement of band 3 in VA taurine efflux, but the issue of the sulfate fluxes remains to be resolved. ..
  74. Capasso G, Unwin R, Agulian S, Giebisch G. Bicarbonate transport along the loop of Henle. I. Microperfusion studies of load and inhibitor sensitivity. J Clin Invest. 1991;88:430-7 pubmed
    ..min-1 was reached. Methazolamide (2 x 10(-4) M) reduced JHCO3 by 70%; the amiloride analogue ethylisopropylamiloride (EIPA) (2 x 10(-4) M) ..
  75. Gelatt K, MacKay E. Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. Vet Ophthalmol. 2001;4:61-7 pubmed
    To compare the reduction in intraocular pressure (IOP) by topical 2% dorzolamide to oral methazolamide (5 mg/kg) in dogs, and determine if the combination of both drugs would reduce IOP more than either drug administered alone...