Summary: Legal documents that are declarations of individuals' wishes regarding the disposal of their property or estate after death; esp: written instruments, legally executed, by which dispositions are made of estates. LIVING WILLS are written declarations regarding prolongation of life by extraordinary means.

Top Publications

  1. ncbi Testamentary capacity and suicide: an overview of legal and psychiatric issues
    Kenneth I Shulman
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Int J Law Psychiatry 26:403-15. 2003
  2. ncbi Psychiatric issues in retrospective challenges of testamentary capacity
    Kenneth I Shulman
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
    Int J Geriatr Psychiatry 20:63-9. 2005
  3. ncbi [Aspects of senile dementia in ancient Rome: literary fiction and factual reality]
    Ferdinand Peter Moog
    Institut fur Geschichte und Ethik der Medizin, Universitat zu Koln
    Sudhoffs Arch 91:73-81. 2007
  4. ncbi [Medico-legal opinions in cases for annulment of testament. Part I. Characteristics of investigative material. Characteristics of testators]
    Jerzy T Marcinkowski
    Katedry Medycyny Społecznej i Katedry i Zakładu Medycyny Sadowej Akademii Medycznej im Karola Marcinkowskiego w Poznaniu
    Arch Med Sadowej Kryminol 57:34-41. 2007
  5. pmc How to assess capacity to make a will
    Robin Jacoby
    University of Oxford, Warneford Hospital, Oxford OX3 7JX
    BMJ 335:155-7. 2007
  6. ncbi Judicial diagnosis. Guardianship and the incapacitated patient
    Lynn Riley
    Personal Financial Planning Department, Hinckley, Allen and Snyder, LLP, 1500 Fleet Center, Providence, RI 02903, USA
    Med Health R I 85:219-20. 2002
  7. ncbi [Will it really bring more clarity or more reason for conflict? Patient self-determination soon to be law]
    Horst Gross
    MMW Fortschr Med 149:12-4, 16. 2007
  8. ncbi Common pitfalls in the evaluation of testamentary capacity
    Thomas G Gutheil
    Program in Psychiatry and the Law, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Am Acad Psychiatry Law 35:514-7. 2007
  9. ncbi The influence of motivational messages on future planning behaviors among HIV concordant positive and discordant couples in Lusaka, Zambia
    R Stephenson
    Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    AIDS Care 20:150-60. 2008
  10. ncbi Re: common pitfalls in the evaluation of testamentary capacity
    Harold J Bursztajn
    J Am Acad Psychiatry Law 36:157. 2008

Detail Information

Publications260 found, 100 shown here

  1. ncbi Testamentary capacity and suicide: an overview of legal and psychiatric issues
    Kenneth I Shulman
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Int J Law Psychiatry 26:403-15. 2003
  2. ncbi Psychiatric issues in retrospective challenges of testamentary capacity
    Kenneth I Shulman
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
    Int J Geriatr Psychiatry 20:63-9. 2005
    Challenges to Wills on the basis of lack of testamentary capacity are likely to increase due to a combination of economic factors, high prevalence of mental disorders in old age and the complexity of many modern families...
  3. ncbi [Aspects of senile dementia in ancient Rome: literary fiction and factual reality]
    Ferdinand Peter Moog
    Institut fur Geschichte und Ethik der Medizin, Universitat zu Koln
    Sudhoffs Arch 91:73-81. 2007
    ..These measures were supposed to prevent extravagancy or doing business and legal acts like marriages or last wills in the state of diminished responsibility...
  4. ncbi [Medico-legal opinions in cases for annulment of testament. Part I. Characteristics of investigative material. Characteristics of testators]
    Jerzy T Marcinkowski
    Katedry Medycyny Społecznej i Katedry i Zakładu Medycyny Sadowej Akademii Medycznej im Karola Marcinkowskiego w Poznaniu
    Arch Med Sadowej Kryminol 57:34-41. 2007
    ..Hence, the testaments were often drawn up in a hospital room or in a notary office where the patient was taken between consecutive hospitalizations...
  5. pmc How to assess capacity to make a will
    Robin Jacoby
    University of Oxford, Warneford Hospital, Oxford OX3 7JX
    BMJ 335:155-7. 2007
  6. ncbi Judicial diagnosis. Guardianship and the incapacitated patient
    Lynn Riley
    Personal Financial Planning Department, Hinckley, Allen and Snyder, LLP, 1500 Fleet Center, Providence, RI 02903, USA
    Med Health R I 85:219-20. 2002
  7. ncbi [Will it really bring more clarity or more reason for conflict? Patient self-determination soon to be law]
    Horst Gross
    MMW Fortschr Med 149:12-4, 16. 2007
  8. ncbi Common pitfalls in the evaluation of testamentary capacity
    Thomas G Gutheil
    Program in Psychiatry and the Law, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Am Acad Psychiatry Law 35:514-7. 2007
    ..Forensic experience reveals that a series of common pitfalls awaits the unwary witness. This brief review identifies the more common pitfalls and suggests how to avoid them...
  9. ncbi The influence of motivational messages on future planning behaviors among HIV concordant positive and discordant couples in Lusaka, Zambia
    R Stephenson
    Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    AIDS Care 20:150-60. 2008
  10. ncbi Re: common pitfalls in the evaluation of testamentary capacity
    Harold J Bursztajn
    J Am Acad Psychiatry Law 36:157. 2008
  11. ncbi Medical confidentiality after a patient's death, with particular reference to The Netherlands
    C Ploem
    University of Amsterdam, The Netherlands
    Med Law 20:215-20. 2001
    ..Whether the position of the latter should be reinforced by introducing statutory provisions, is to be further explored...
  12. ncbi Property grabbing and will writing in Lusaka, Zambia: an examination of wills of HIV-infected cohabiting couples
    E Mendenhall
    Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    AIDS Care 19:369-74. 2007
    ..The Zambia-Emory HIV Research Project collected 184 wills from individuals in monogamous unions where one or both of the individuals were HIV-positive...
  13. ncbi [Psychiatric-psychological opinions in cases of declaration of will invalidation with emphasis on assessment of discretion]
    Elzbieta Skupień
    Z Zakładu Psychologii Sadowej Instytutu Ekspertyz Sadowych im Prof Jana Sehna w Krakowie
    Arch Med Sadowej Kryminol 58:37-42. 2008
  14. ncbi Where there's a will
    Sara Bird
    Bird, Sara
    Aust Fam Physician 33:843-4. 2004
  15. ncbi Exploring the law regarding the making and execution of wills
    Bridgit Dimond
    University of Glamorgan, UK
    Br J Nurs 14:152-3. 2005
  16. ncbi The law regarding health records of the deceased in the UK
    Bridgit Dimond
    University of Glamorgan
    Br J Nurs 14:391-2. 2005
    ..Ben is seeking to access his father's health records to try and establish the mental state of his father at the time he made the will. He has applied to see the records. Will he be able to access them?..
  17. ncbi Wills and the district nurse: the importance of caution
    Richard Griffith
    Centre for Philosophy, Law and Healthcare, University of Wales, Swansea
    Br J Community Nurs 10:387-91. 2005
    ..Julie does not want to get involved but feels pressurized by John into signing and witnessing the will. John dies a week later. Julie is notified that the will is being contested by Sarah...
  18. ncbi The Family Wealth Preservation Trust Act: a new asset protection tool
    Cori H Loomis
    J Okla State Med Assoc 97:503. 2004
  19. ncbi State policy decisions in the 1990s with implications for the financial well-being of later-life families
    Gretchen J Hill
    Department of Criminology, Sociology, and Geography, Arkansas State University, P O Box 2410, State University, AR 72467, USA
    J Aging Soc Policy 18:211-27. 2006
    ..Research was suggested to answer questions raised by this study...
  20. ncbi Assessment of competency: a primer
    Danuta Mendelson
    School of Law, Deakin University
    J Law Med 14:156-66. 2006
    ..The relevant tests and special factors are examined from an historical perspective...
  21. ncbi Sharing the wealth: the effect of siblings on adults' wealth ownership
    Lisa A Keister
    Department of Sociology, Ohio State University, 300 Bricker Hall, 190 North Oval Mall, Columbus, OH 43210, USA
    Demography 40:521-42. 2003
    ..The findings provide important insights into early family processes that shape wealth accumulation and inequality...
  22. ncbi Exploring the health-wealth nexus
    Jonathan Meer
    Department of Economics, Stanford University, Stanford, CA 94305, USA
    J Health Econ 22:713-30. 2003
    ..And even when the point estimate is increased by twice its standard error (S.E.), the quantitative effect is small. We conclude that the wealth-health connection is not driven by short run changes in wealth...
  23. ncbi Access to health care records after death: balancing confidentiality with appropriate disclosure
    David J Robinson
    Department of Medical Gerontology, Adelaide and Meath Hospital, Dublin, Ireland
    JAMA 297:634-6. 2007
  24. ncbi Widow inheritance and HIV/AIDS in rural Uganda
    E D Mabumba
    Kashari Health Sub District, Mbarara District, PO Box 1, Mbarara, Uganda
    Trop Doct 37:229-31. 2007
    ..Voluntary counselling and testing is needed for the widows and their inheritors; formal dowry should be removed from marriage and widow inheritance stripped of its sexual component...
  25. ncbi Securing your family's future: the value of estate planning
    Ellen Rinaldi
    Investment Counseling and Research, The Vanguard Group, Valley Forge, PA 19482, USA
    J Am Dent Assoc 137:1139-43. 2006
    ..They also stress the importance of planning for incapacity...
  26. ncbi [Doctor, do you love your wife? Then make a testament!]
    Bernhard Mäulen
    Instituts für Arztegesundheit 78048 Villingen Schwenningen
    MMW Fortschr Med 145:4-8. 2003
  27. ncbi Ethical issues in the management of geriatric cardiac patients
    Lofty L Basta
    University of South Florida, Tampa, FL, USA
    Am J Geriatr Cardiol 14:331-2. 2005
    ..The cardiologist acted in good faith, which resulted in losing the legal battle, the support of the hospital administration, and the friendship of the pulmonologist...
  28. ncbi Custody plans among parents living with human immunodeficiency virus infection
    Mary Jane Rotheram-Borus
    AIDS Institute, Center for HIV Identification, Prevention, and Treatment Services, University of California, Los Angeles 90094 6521, USA
    Arch Pediatr Adolesc Med 158:327-32. 2004
    ..To describe and to examine predictors of making custody plans by parents living with the human immunodeficiency virus (HIV) infection...
  29. ncbi [Are the "elderly" living at the expense of the "young"? Remarks on the burden distribution between "generations" in an aging population from the economic perspective]
    W Schmahl
    Zentrum für Sozialpolitik, Universitat Bremen, Parkallee 39 28209 Bremen, Germany
    Z Gerontol Geriatr 35:304-14. 2002
    ..This requires an elaborated and differentiated reporting of distributional effects. This important precondition, however, does not exist in Germany...
  30. ncbi Equal division of estates and the exchange motive
    Edward C Norton
    Department of Health Policy and Administration, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 7411, USA
    J Aging Soc Policy 17:63-82. 2005
    ..The models control for selection, because many decedents do not file a record in probate court...
  31. ncbi Beyond death: inheriting the past and giving to the future, transmitting the legacy of one's self
    Elizabeth G Hunter
    Cardinal Hill Rehabilitation Hospital, Lexington, Kentucky 40504, USA
    Omega (Westport) 56:313-29. 2007
    ..While the idea of legacy is often couched in terms of material possessions, it appears that passing on values and beliefs is more important to older adults...
  32. ncbi How does the mode of inheritance of a genetic condition influence families? A study of guilt, blame, stigma, and understanding of inheritance and reproductive risks in families with X-linked and autosomal recessive diseases
    Cynthia A James
    Department of Medicine, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Genet Med 8:234-42. 2006
    ..While the mode of inheritance of a genetic condition has long been considered to have not only medical, but also psychosocial consequences for families, this supposition has never been tested...
  33. ncbi Family security with a comprehensive financial plan
    Brian Kuefler
    First Tennessee Bank, USA
    Tenn Med 99:35. 2006
  34. ncbi [Interview with attorney Gerhard Ruby, Villingen-Schwenningen. Practical tips on inheritance law]
    Gerhard Ruby
    MMW Fortschr Med 145:10. 2003
  35. ncbi Estate planning for the second time around
    Maureen E Hansen
    SVA Planners Inc, Brookfield, Wis, USA
    WMJ 102:93-4. 2003
  36. ncbi Securing the future
    William Stewart
    J Am Dent Assoc 137:1368; author reply 1368, 1370. 2006
  37. ncbi Dont let poor estate planning checkmate your family's future
    Howard M Rochestie
    J Mich Dent Assoc 85:34-7. 2003
  38. ncbi Protect your wealth now and later
    Howard M Rochestie
    N Y State Dent J 69:40-2. 2003
  39. ncbi Estate planning
    John W Reeder
    LDA J 62:24-5. 2003
  40. ncbi Estate planning
    John W Reeder
    LDA J 62:16-7. 2003
  41. ncbi Life insurance and its effect on estate taxation
    Joel M Blau
    MEDIQUS Asset Advisors, Inc, 200 N LaSalle Street, Suite 500, Chicago, IL 60601, USA
    J Med Pract Manage 17:210-2. 2002
    ..Fortunately for most physicians, this ultimate liability has been drastically reduced, but it also has become much more complex. The key is to plan proactively with an understanding of the most current estate tax savings strategies...
  42. ncbi Care of patients with haemoglobin abnormalities: history and biology
    Ahmed D Khattab
    Department of Nursing, Institute of Health and Community Studies, Bournemouth University
    Br J Nurs 15:994-8. 2006
    ..This article will focus on the biological basis of sickle cell disorders and will discuss the history and pathology of the conditions...
  43. ncbi A novel splice acceptor mutation in the DSPP gene causing dentinogenesis imperfecta type II
    J W Kim
    Department of Biological and Material Sciences, University of Michigan Dental Research Laboratory, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    Hum Genet 115:248-54. 2004
    ..Permanent dentition was severely affected in the adults, who had advanced dental attrition, premature loss of teeth, and extensive dental reconstruction...
  44. ncbi Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus
    Cecilia M Johansson
    Department of Genetics and Pathology, Unit for Medical Genetics, Rudbeck Laboratory, University of Uppsala, Dag Hammarskjölds väg 20, Uppsala, Sweden
    Hum Genet 115:230-8. 2004
    ..Several other interesting regions were found at 1p35, 1q31, 3q26, 5p15, 11q23 and 19q13, confirming previously identified loci for SLE or other autoimmune diseases...
  45. ncbi Disposition of a dental practice upon the death of a dentist
    Daniel J Schulte
    J Mich Dent Assoc 87:18. 2005
  46. ncbi Where there's a will, there's a way. . . Part 1--protecting the future of your estate
    Elisabeth McDowell
    Aust Vet J 83:600-1. 2005
  47. ncbi Inheritance of cluster headache and its possible link to migraine
    L Kudrow
    California Medical Clinic for Headache, Encino 91436
    Headache 34:400-7. 1994
    ..f 1652 relatives of all cluster patients, 3.45% had cluster headache (thirteen times the expected frequency of cluster headache in the general population) and 17.55% had migraine headaches.(ABSTRACT TRUNCATED AT 250 WORDS)..
  48. ncbi Periodic catatonia: a schizophrenic subtype with major gene effect and anticipation
    G Stober
    Department of Psychiatry, University of Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 245:135-41. 1995
    ..Thus, periodic catatonia as a specific clinical subtype of schizophrenia is a promising candidate for molecular genetic evaluation...
  49. ncbi Infantile scoliosis in Marfan syndrome
    P D Sponseller
    Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland, USA
    Spine (Phila Pa 1976) 22:509-16. 1997
    ..Instrumentation without fusion should be considered only for patients with no significant kyphosis. Results of fusion are better for patients who are older than five years of age...
  50. ncbi Heat stress-induced life span extension in yeast
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:379-88. 1998
    ..The results raise the possibility that the RAS genes and mitochondria may play a role in the epigenetic inheritance of reduced mortality rate afforded by transient, mild heat stress...
  51. ncbi [Genetics of hereditary cardiopathies]
    S Debrus
    CRBM, CNRS UPR 9008 et INSERM U249, Montpellier
    Arch Mal Coeur Vaiss 89:619-27. 1996
    ..1, 3p22 and 12q1). In the near future, these incoming data will deeply modify the cardiovascular field...
  52. ncbi [Acute intermittent familial ataxia: report of a new family]
    M J Pérez-Rodríguez
    Secci de Neuropediatría, Servicio de Pediatria, Hospital Ramon y Cajal, Madrid
    Rev Neurol 24:570-1. 1996
    ..For this purpose, a therapeutic test with acetazolamide can be useful, since in most cases a spectacular clinical improvement has been observed...
  53. pmc Genetic exchange of determinants for capsular polysaccharide biosynthesis between Klebsiella pneumoniae strains expressing serotypes K2 and K21a
    I Ofek
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel-Aviv University, Israel
    Infect Immun 61:4208-16. 1993
    ..However, KPA5, expressing the heterologous K21a CPS, was unusual in that the uniform capsular layer was physically separated from the cell wall by approximately 50 nm.(ABSTRACT TRUNCATED AT 400 WORDS)..
  54. ncbi Cardiovascular characteristics in Marfan syndrome and their relation to the genotype
    J De Backer
    Dienst Cardiologie, Centrum voor Medische Genetica Vakgroep Pediatrie en Genetica, Fac Geneeskunde en Gezondheidswetenschappen, UGent De Pintelaan 185, B 9000 Gent
    Verh K Acad Geneeskd Belg 71:335-71. 2009
    ..Overall, this thesis nicely illustrates that close interaction and collaboration between cardiology and genetics is an added value to the study of disease pathogenesis of MFS and aortic aneurysms in general...
  55. ncbi Co-inheritance of alpha-and beta-thalassemia in Khuzestan Province, Iran
    Fakher Rahim
    Research Center of Physiology, Ahwaz Jondishapur University of Medical Sciences, Ahwaz, Iran
    Hematology 13:59-64. 2008
    ..Individuals who have one or two abnormal alpha globin genes have alpha-thalassemia trait. The aim of this study was to detect alpha-thalassemia in beta-thalassemia carriers during prenatal screening...
  56. ncbi Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance
    Douglas E Crompton
    Department of Medicine and Epilepsy Research Centre, University of Melbourne, Austin Health, West Heidelberg, Victoria, Australia
    Brain 133:3221-31. 2010
  57. ncbi A genetic analysis of human minor histocompatibility antigens demonstrates Mendelian segregation independent of HLA
    G M Schreuder
    Department of Immunohaematology, University Hospital Leiden, The Netherlands
    Immunogenetics 38:98-105. 1993
    ..While we are aware of the limited results of this nonetheless comprehensive study, we feel the similarity in immunogenetic traits between human and mouse mH antigens is at least striking...
  58. ncbi Occurrence of plastids in the sperm cells of Caprifoliaceae: biparental plastid inheritance in angiosperms is unilaterally derived from maternal inheritance
    Yingchun Hu
    Key Laboratory of Cell Proliferation and Differentiation Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, PR China
    Plant Cell Physiol 49:958-68. 2008
    ..Thus, unlike previous studies, we suggest that biparental plastid inheritance in angiosperms was unilaterally converted from the maternal transmission mode during late angiosperm evolution...
  59. ncbi The selective increase or decrease of organellar DNA in generative cells just after pollen mitosis one controls cytoplasmic inheritance
    N Nagata
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Planta 209:53-65. 1999
    ..These results indicate that the modes of inheritance (paternal/biparental inheritance or maternal inheritance) of mitochondria and plastids are determined independently of each other in young generative cells just after PMI...
  60. ncbi Primary aldosteronism: learning from the study of familial varieties
    M Stowasser
    University Department of Medicine, Greenslopes Hospital, Brisbane, Australia
    J Hypertens 18:1165-76. 2000
  61. ncbi Inheritance patterns, dominance, stability, and allelism of insecticide resistance and cross-resistance in two colonies of Culex quinquefasciatus (Diptera: Culicidae) selected with cry toxins from Bacillus thuringiensis subsp, israelensis
    Margaret C Wirth
    Department of Entomology, University of California, Riverside, CA 92521, USA
    J Med Entomol 47:814-22. 2010
    ..thuringiensis subsp. israelensis de Barjac...
  62. ncbi Evolution of hierarchical cytoplasmic inheritance in the plasmodial slime mold Physarum polycephalum
    Akiko Iwanaga
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812 8581, Japan
    Evolution 58:710-22. 2004
    ..Based on the theoretical results of the site-specific nuclease model, we propose that a nested subsequence structure in the recognition sequence should underlie the linear dominance hierarchy of mitochondrial transmission...
  63. ncbi Mechanism and evolution of hypoxia-tolerance in humans
    P W Hochachka
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Exp Biol 201:1243-54. 1998
    ..More recent evidence indicating that our species evolved under 'colder, drier and higher' conditions suggests that these adaptations may represent the 'ancestral' physiological condition for humans...
  64. pmc Comparative mitochondrial genomics of freshwater mussels (Bivalvia: Unionoida) with doubly uniparental inheritance of mtDNA: gender-specific open reading frames and putative origins of replication
    Sophie Breton
    Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA
    Genetics 183:1575-89. 2009
    ..We propose that unassigned regions are the most promising candidate sequences in which to find regulatory and/or gender-specific sequences that could determine whether a mitochondrial genome will be maternally or paternally transmitted...
  65. ncbi Multifunctional Merkel cells: their roles in electromagnetic reception, finger-print formation, Reiki, epigenetic inheritance and hair form
    M Kemal Irmak
    Department of Histology and Embryology, School of Medicine, Gulhane Military Medical Academy, 06018 Etlik Ankara, Turkey
    Med Hypotheses 75:162-8. 2010
    ..In conclusion, Merkel cells are multifunctional cells which may close the gap between orthodox medicine and complementary medicine such as acupuncture and Reiki...
  66. ncbi Differences in end-of-life decision making among black and white ambulatory cancer patients
    E D McKinley
    Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109-1998, USA
    J Gen Intern Med 11:651-6. 1996
    ..white individuals have been shown to differ in their desire for life-sustaining treatments and their use of living wills for end-of-life care, but the reasons for these differences are unclear...
  67. ncbi Progressive osseous heteroplasia-like heterotopic ossification in a male infant with pseudohypoparathyroidism type Ia: a case report
    Inessa M Gelfand
    Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, IN, USA
    Bone 40:1425-8. 2007
    ..Mutations that cause PHP Ia when maternally inherited can cause POH when paternally inherited. We present an unusual case of a boy with clinical features of both POH and PHP Ia, and a GNAS inactivating mutation...
  68. ncbi Visualization of uniparental inheritance, Mendelian inconsistencies, deletions, and parent of origin effects in single nucleotide polymorphism trio data with SNPtrio
    Jason C Ting
    Department of Neurology, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Hum Mutat 28:1225-35. 2007
    ..SNPtrio is freely accessible at http://pevsnerlab.kennedykrieger.org/SNPtrio.htm (Last accessed: 20 June 2007)...
  69. ncbi Thalassemia intermedia in HbH-CS disease with compound heterozygosity for beta-thalassemia: challenges in hemoglobin analysis and clinical diagnosis
    Jin Ai Mary Anne Tan
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Genes Genet Syst 84:67-71. 2009
    ..The presence of both the SEA deletion and CD41/42 in the mother of the patient suggests the possible introduction of these two defects into the family by marriage with a Chinese...
  70. pmc Analysis of gene order data supports vertical inheritance of the leukotoxin operon and genome rearrangements in the 5' flanking region in genus Mannheimia
    Jesper Larsen
    Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    BMC Evol Biol 7:184. 2007
    ..We have tested the hypothesis that vertical inheritance of the leukotoxin (lktCABD) operon has occurred from the last common ancestor of genus Mannheimia to any ancestor of the diverging subclades by exploring gene order data...
  71. ncbi Ocular and nonocular findings in patients with aniridia
    Alejandra Valenzuela
    Department of Ophthalmology and Visual Science, British Columbia Children s Hospital, University of British Columbia, Vancouver, BC
    Can J Ophthalmol 39:632-8. 2004
    ..In this report we describe the various ocular manifestations of aniridia as well as the association of familial aniridia with two different ocular and systemic abnormalities present across three generations in two different families...
  72. pmc Advance directives and outcomes of surrogate decision making before death
    Maria J Silveira
    Veterans Affairs Center for Clinical Management Research, and Division of General Medicine, University of Michigan, Ann Arbor, USA
    N Engl J Med 362:1211-8. 2010
    ..Recent discussions about health care reform have raised questions regarding the value of advance directives...
  73. ncbi Inheritance of resistance to mammalian herbivores and of plant defensive chemistry in a Eucalyptus species
    Julianne M O'Reilly-Wapstra
    School of Zoology, CRC for Sustainable Production Forestry, University of Tasmania, Hobart, Tasmania, Australia
    J Chem Ecol 31:519-37. 2005
    ..Their combined concentration, however, was inherited in an additive manner, consistent with the phenotypic differences in browsing...
  74. ncbi [Collagen type IV nephropathy: from thin basement membrane nephropathy to Alport syndrome]
    Emoke Endreffy
    Szegedi Tudomanyegyetem, Szent Györgyi Albert Orvos és Gyógyszerésztudományi Centrum, Általános Orvostudományi Kar, Gyermekgyógyászati Klinika es Gyermekegészségügyi Központ, Szeged
    Orv Hetil 146:2647-53. 2005
    ..About 14% of Alport syndrome cases exhibit autosomal recessive, and 1% autosomal dominant inheritance, both caused by mutations in the Col(IV)A3 or Col(IV)A4 genes in boys and in girls...
  75. ncbi Inheritance of resistance to mammalian herbivores and of plant defensive chemistry in an Eucalyptus species
    Julianne M O'Reilly-Wapstra
    School of Zoology, CRCfor Sustainable Production Forestry, University of Tasmania Private Bag 5, Hobart, Tasmania, Australia, 7001
    J Chem Ecol 31:357-75. 2005
    ..Their combined concentration, however, was inherited in an additive manner, consistent with the phenotypic differences in browsing...
  76. ncbi Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant
    F D Grant
    Endocrinology Hypertension Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 83:3958-64. 1998
  77. ncbi Germline Mosaicism for KIF21A Mutation (p.R954L) Mimicking Recessive Inheritance for Congenital Fibrosis of the Extraocular Muscles
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Department of Genetics, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Ophthalmology 117:154-8. 2010
    ..To document the genotype for familial congenital fibrosis of the extraocular muscles (CFEOM) with apparent autosomal recessive inheritance...
  78. pmc Peroxisomal peripheral membrane protein YlInp1p is required for peroxisome inheritance and influences the dimorphic transition in the yeast Yarrowia lipolytica
    Jinlan Chang
    Department of Cell Biology, University of Alberta, MSB 5 14, Edmonton, Alberta T6G 2H7, Canada
    Eukaryot Cell 6:1528-37. 2007
    ..This study reports the first analysis of organelle inheritance in a true dimorphic yeast and identifies the first protein required for peroxisome inheritance in Y. lipolytica...
  79. pmc Epigenetic inheritance in rice plants
    Keiko Akimoto
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Ann Bot 100:205-17. 2007
    ..The present study aims to find genes whose methylation status directly correlates with inheritance of phenotypic changes...
  80. ncbi Neonatal thyroid disorders
    Annette Gruters
    Department of Paediatric Endocrinology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    Horm Res 59:24-9. 2003
  81. ncbi No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families
    P Pajukanta
    National Public Health Institute, Department of Human Molecular Genetics, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 17:841-50. 1997
    ..Data obtained by the affected sib-pair method supported these findings, suggesting that the LPL, HL, or HSL genes do not represent major loci influencing the expression of the FCHL phenotype...
  82. ncbi Toyama Kametaro and Vernon Kellogg: silkworm inheritance experiments in Japan, Siam, and the United States, 1900-1912
    Lisa Onaga
    Department of Science and Technology Studies, Cornell University, 311 Rockefeller Hall, Ithaca, NY 14853, USA
    J Hist Biol 43:215-64. 2010
    ..All these shed light on the challenges that came along with the use of agricultural animals to convincingly articulate new biological principles...
  83. ncbi Inheritance of cleft palate in Italy. Evidence for a major autosomal recessive locus
    M Clementi
    Dipartimento di Pediatria, Universita di Padova, Italy
    Hum Genet 100:204-9. 1997
    ..Application of the candidate genes to human CPH families could reveal whether these genes are involved...
  84. pmc A Bayesian approach for discriminating among alternative inheritance hypotheses in plant polyploids: the allotetraploid origin of genus Borderea (Dioscoreaceae)
    Pilar Catalán
    Departamento de Agricultura y Economía Agraria, Escuela Superior Politécnica de Huesca, Universidad de Zaragoza, Huesca, Spain
    Genetics 172:1939-53. 2006
    ..These results, along with previous allozyme data, support the allotetraploid origin of this paleoendemic genus and reveal the lowest reported chromosome base number for the family of the yams...
  85. pmc Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model
    Gwo Hsiao Chen
    VA Medical Center Ann Arbor, Ann Arbor, MI 48105, USA
    Infect Immun 76:2379-91. 2008
    ..The enhanced pulmonary lymphocyte recruitment could be responsible for a gradual shutdown of the undesirable Th2 arm of the immune response and subsequently improved anticryptococcal resistance in F1 mice...
  86. pmc Cytoplasmic inheritance of transplantation antigens in animals produced by nuclear transfer
    John S Hanekamp
    Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Transplantation 88:30-7. 2009
    ..These studies examine the potential consequences of such inheritance in a large animal transplantation model...
  87. pmc Sex-linked inheritance in macaque monkeys: implications for effective population size and dispersal to Sulawesi
    Ben J Evans
    Department of Biology, McMaster University, Life Sciences Building, Hamilton, Ontario L8S 4K1, Canada
    Genetics 185:923-37. 2010
    ..One X-linked locus was not monophyletic on Sulawesi, but multilocus data analyzed in a coalescent framework failed to reject a model without migration between these islands after both were colonized...
  88. ncbi Family study of the inheritance of pectus excavatum
    Heather A Creswick
    Division of Medical Genetics and Metabolism, Department of Pediatrics, Children s Hospital of the King s Daughters, Norfolk, VA 23507, USA
    J Pediatr Surg 41:1699-703. 2006
    ..Pectus excavatum is commonly associated with connective tissue disorders such as Marfan and Ehlers Danlos syndromes. Extensive literature review failed to identify articles documenting families with multiple affected members...
  89. ncbi Evidence that an imprinted gene on the X chromosome increases ovulation rate in sheep
    G H Davis
    Invermay Agricultural Centre, Mosgiel, New Zealand
    Biol Reprod 64:216-21. 2001
    ..The gene was not expressed in ewes that received it from either carrier dams (expressing or nonexpressing) or from carrier males that were the progeny of expressing carrier dams...
  90. ncbi Endosperm-specific hypomethylation, and meiotic inheritance and variation of DNA methylation level and pattern in sorghum (Sorghum bicolor L.) inter-strain hybrids
    M S Zhang
    Laboratory of Plant Molecular Epigenetics, Institute of Genetics and Cytology, Northeast Normal University, Changchun, 130024, China
    Theor Appl Genet 115:195-207. 2007
    ..Analysis on leaf-RNA from 5-azacytidine-treated plants further corroborated this possibility...
  91. ncbi The importance of autosomal genes in Kallmann syndrome: genotype-phenotype correlations and neuroendocrine characteristics
    L M Oliveira
    Reproductive Endocrine Sciences Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:1532-8. 2001
    ..Taken together, these findings suggest that autosomal genes account for the majority of familial cases of KS, and that unique neuroendocrine phenotypes consistent with some GnRH neuronal migration may exist in these patients...
  92. ncbi Genetic and nongenetic influences on vigor at birth and preweaning mortality of purebred and high percentage Brahman calves
    D G Riley
    ARS, USDA, Subtropical Agricultural Research Station, Brooksville, FL 34601, USA
    J Anim Sci 82:1581-8. 2004
    ..06 +/- 0.05 and 0.09 +/- 0.04, respectively, for preweaning mortality. Some exploitable genetic variation exists for these traits, but management of other factors may yield more immediate improvement than selection...
  93. ncbi Isolation, characterization, inheritance and linkage of microsatellite DNA markers in white spruce (Picea glauca) and their usefulness in other spruce species
    O P Rajora
    Department of Biology, Life Sciences Centre, Dalhousie University, Halifax, NS, Canada
    Mol Gen Genet 264:871-82. 2001
  94. pmc New insights into cystinuria: 40 new mutations, genotype-phenotype correlation, and digenic inheritance causing partial phenotype
    M Font-Llitjos
    Centre of Medical and Molecular Genetics IRO, Hospital Duran i Reynals, Barcelona, Spain
    J Med Genet 42:58-68. 2005
    ..To clarify the genotype-phenotype correlation and elucidate the role of digenic inheritance in cystinuria...
  95. ncbi Mapping Fusarium wilt race 1 resistance genes in cotton by inheritance, QTL and sequencing composition
    Mauricio Ulloa
    USDA ARS, Western Integrated Cropping Systems Research Unit, Shafter, CA 93263, USA
    Mol Genet Genomics 286:21-36. 2011
    ..These offer candidate gene targets for Fusarium wilt resistance response in cotton and other host plants...
  96. ncbi The GNAS locus and pseudohypoparathyroidism
    Murat Bastepe
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Adv Exp Med Biol 626:27-40. 2008
    ..Most sporadic PHP-Ib cases also have imprinting abnormalities of GNAS that involve multiple DMRs, but the genetic lesion(s) responsible for these imprinting abnormalities remain to be discovered...
  97. ncbi The model plant Medicago truncatula exhibits biparental plastid inheritance
    Ryo Matsushima
    Research Institute for Bioresources, Kurashiki University, Kurashiki, Okayama, 710 0046 Japan
    Plant Cell Physiol 49:81-91. 2008
    ..Collectively, these data demonstrated that M. truncatula is biparental for ptDNA transmission and thus can be an excellent model to study plastid genetics in angiosperms...
  98. pmc Prevalence, phenotype and inheritance of benign neutropenia in Arabs
    Srdjan Denic
    Department of Internal Medicine, Faculty of Medicine and Health Sciences, UAE University, Al Ain, UAE
    BMC Blood Disord 9:3. 2009
    ..CONCLUSION: Arabs have a high prevalence of benign neutropenia that may be inherited as an autosomal dominant trait...
  99. ncbi Centrosome dynamics and inheritance in related sexual and parthenogenetic Bacillus (Insecta Phasmatodea)
    Ombretta Marescalchi
    Dipartimento di Biologia Evoluzionistica Sperimentale, Bologna, Italy
    Mol Reprod Dev 63:89-95. 2002
    ..In stick insects, the lack of sperm contribution to embryonic centrosome appears to be a major trait accounting for the widespread occurrence of facultative and obligate parthenogenesis within the order...
  100. ncbi The influence of age on maternal inheritance of breast muscle morphology in turkeys
    S G Velleman
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    Poult Sci 89:876-82. 2010
    ..Based on the results, the type of mating used to produce commercial turkeys would have a major effect on breast muscle morphology from 12 through 18 wk of age...
  101. ncbi Environment factors can influence mitochondrial inheritance in the fungus Cryptococcus neoformans
    Zhun Yan
    Department of Biology, McMaster University, 1280 Main St W, Hamilton, Ont, Canada L8S 4K1
    Fungal Genet Biol 44:315-22. 2007
    ..Our results indicate a potentially adaptive role of biparental mtDNA inheritance and mtDNA recombination in certain environments in C. neoformans...

Research Grants73

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  3. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..The contractor is responsible for providing staff with the credentials required by CLIA. ..
  4. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
    ..Studying the untoward effects of mutant ET genes will increase our knowledge of ET and other movement disorders such as Parkinson disease. ..
    Tibor T Glant; Fiscal Year: 2013
    ..We propose to reduce the size of these regions in the mouse genome, which cannot be done in human population, and select candidate genes that may be involved in arthritis susceptibility and disease severity. ..
  6. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..abstract_text> ..
  7. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2012
    ..abstract_text> ..
  8. Contribution of Gstm1 to the severity of hypertension and chronic kidney disease
    Thu H Le; Fiscal Year: 2013
    ..The relative contribution of the enzymatic and functional non-enzymatic domains of GSTM1 on VSMC proliferation, migration and oxidative stress will also be determined. ..
  9. The role of NLRP7 and related genes in hydatidiform moles and reproductive failur
    Ignatia Van den Veyver; Fiscal Year: 2009
    ..This project has the potential to result in new understanding of genetic imprinting disorders and causes of obstetrics complications and pregnancy loss in general. ..
  10. Cloning &Functional Studies of Deafness Mutations
    Kenneth R Johnson; Fiscal Year: 2013
  11. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..Our goal is to unveil modifiable conditions in order to prevent obesity and related diseases including cardiovascular disease and diabetes. ..
  12. NeuroMolecular consequences of adolescent binge drinking
    Toni R Pak; Fiscal Year: 2013
  13. Mechanics and regulation of chromosome dynamics in meiotic prophase
    MICHAEL EDWARD DRESSER; Fiscal Year: 2012
    ..Understanding this new process will provide a new perspective to understand how chromosomes are prepared for inheritance and what makes chromosome transmission fail so frequently in humans. ..
  14. Molecular and cellular mechanism of Microcephaly
    Arnold Kriegstein; Fiscal Year: 2013
  15. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..This research will elucidate the role of tooth/bone matrix material properties in oral and skeletal health and disease. ..
  16. Contribution of Sperm Nucleus to Paternal DNA Replication
    WILLIAM S WARD; Fiscal Year: 2013
    ..This application proposes to test the idea that the sperm cell brings to the egg more than only the DNA, itself, but instructions on how to replicate it properly in the first embryonic cell division. ..
  17. A search for genes that regulate allogeneic stem cell competition
    Irving L Weissman; Fiscal Year: 2013
    ..Allelic polymorphism of mouse and human genes, with homology to genes that alter stem cell competition potential in Botryllus will be analyzed;if found, we will determine whether these are related to transplantation outcomes. ..
  18. The Molecular Mechanisms by which the Paf Oncogene Mediates Hematopoiesis
    Lisa K Denzin; Fiscal Year: 2013
    ..The data from these experiments represent an essential step towards delineating the molecular mechanisms by which Paf functions to mediate hematopoiesis. ..
  19. Transgenerational epigenetic inheritance of allergy in a multigenerational cohort
    WILFRIED JJ KARMAUS; Fiscal Year: 2013
    ..Now, to move toward prevention, we need to understand whether programming, reprogramming, and vertical transmission of DNA methylation can predict allergic diseases in infancy. ..
  20. Genetic analysis of the ciliopathies ARPKD and Meckel syndrome
    Peter C Harris; Fiscal Year: 2013
    ..These studies will be of diagnostic and prognostic importance in these disorders and help to understand the true complexity of simple genetic diseases. ..
  21. Transgenerational Inheritance of Epigenetic Effects of Polychlorinated Biphenyls
    Charles V Vorhees; Fiscal Year: 2013
    ..Successful demonstration of transgenerational inheritance in response to in utero PCB exposure will transform our understanding of the health effects of these ubiquitous environmental pollutants. ..
  22. Role of Intronic Variants Affecting Splicing in Juvenile Myoclonic Epilepsy
    Debra J Wolgemuth; Fiscal Year: 2010
  23. Regulation of chromosome segregation by SMC complexes and Top2 in S. pombe
    MATTHEW J O'CONNELL; Fiscal Year: 2013
    ..This project studies proteins that are essential for accurate inheritance of chromosomes as cells divide. The public health relevance is thus central to the biology of cancer and aging. ..
    Ethylin Wang Jabs; Fiscal Year: 2010
    ..abstract_text> ..
  25. Characterization of RGC death susceptibility alleles
    Robert W Nickells; Fiscal Year: 2013
    ..Finding and characterizing these alleles will lead to better diagnosis and treatment regimes for individuals with glaucoma. ..
    Michael L Cunningham; Fiscal Year: 2013
    ..There is an incomplete understanding of the causes of craniosynostosis and we lack experimental models. The development of these resources will improve clinical care, design biologically based therapies, and pursue primary prevention. ..
  27. Epithelial Regulation of Th2 Immune Responses in the Lung
    Marsha Wills-Karp; Fiscal Year: 2013
    ..List all other key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Wills-Karp, Marsha Wildc7 CCHMC PI Finkelman, Fred frefin CCHMC Co-Investigator
  28. Telomere Shortening and Stem Cell Maintenance
    Mary Y Armanios; Fiscal Year: 2010
    ..These effects are particularly relevant as telomerase inhibitors are actively pursued as anti-cancer therapies. ..
  29. Identification and Characterization of the Mouse PPCD1 Gene
    Christopher A Bradfield; Fiscal Year: 2013
    ..Putative causative mutations will be tested using in vitro functional assays. Finally, through linkage analysis, we will look for C57BL/6J modifier loci that influence the penetrance of PPCD1. ..
  30. Organization and Regulation of Eukaryotic Centromeres
    BETH SULLIVAN; Fiscal Year: 2009
    ..We propose to investigate the roles of genomic structure and chromatin organization and dynamics in assembly and regulation of CENP-A chromatin, centromeric domains, and metaphase kinetochore structure. ..
    Harald W Jueppner; Fiscal Year: 2013
  32. Genetic Basis of Nanophthalmos and Human Ocular Biometry
    Olof H Sundin; Fiscal Year: 2010
  33. Immune and genetic determinants of murine glomerulonephritis
    Elahna Paul; Fiscal Year: 2012
    ..abstract_text> ..
  34. Transgenerational effects of nicotine in F1 generation of exposed fathers in mice
    Markus Vallaster; Fiscal Year: 2013
    ..This will lead to new approaches in prevention and treatment of nicotine dependence and diseases linked to chronic nicotine exposure and its transgenerational inheritance. ..
  35. Genetics and biology of a viable mutant mouse with dystonic movements
    Kathleen J Sweadner; Fiscal Year: 2013
  36. Fluorescent Copper Probes for Intracellular Imaging
    Christoph J Fahrni; Fiscal Year: 2013
  37. Rapid-onset Dystonia Parkinsonism (DYT12 Dystonia): Pathophysiology &Atp1a3 Mice
    Yuqing Li; Fiscal Year: 2011
  38. Determinants of growth and fitness in drug resistant malaria parasites
    Michael T Ferdig; Fiscal Year: 2012
    ..This knowledge will lead to new avenues of attack against this disease. ..
  39. Epigenetic regulation of metabolism in Drosophila
    Carl S Thummel; Fiscal Year: 2013
  40. Genetic Regulation of Complex Neurological Disease
    Wayne N Frankel; Fiscal Year: 2012
    ..The system provides a new kind of model, influenced by, but extending beyond polygenic inheritance, for understanding the architecture of complex neurological disease. ..
  41. Individual Predoctoral Dental Scientist Fellowship
    Ejvis Lamani; Fiscal Year: 2011
    ..Eventually the proposed studies will facilitate the development of novel diagnostic tools and therapeutic treatments for patients with various diseases or syndrome with altered root formation. ..
  42. PTEN Deficiency and Tumor Development
    Yuxin Yin; Fiscal Year: 2012
    ..Identification of the PTEN-mitotic pathway may offer a profound implication for development of therapeutic strategies against tumorigenesis. ..
  43. Regulation and Function of a Bacterial Cytoskeleton
    R Dyche Mullins; Fiscal Year: 2013
  44. Mechanisms of Polycomb Silencing
    Yi Zhang; Fiscal Year: 2010
    ..5. .Determine the transcriptional effect and understand the mechanism of H3K27 methylation and H2A ubiquitylation using a reconstituted chromatin transcription system. More description in proposal. ..
  45. The Role of Genome-Coded ME2 in Epilepsy
    David A Greenberg; Fiscal Year: 2010
    ..We propose to determine how polymorphisms found in the ME2 gene increase susceptibility to a broad class of related epilepsy syndromes. ..
  46. The Nuclear Pore Complex: Interphase and Mitotic Function
    Katharine S Ullman; Fiscal Year: 2012
    ..Such defects in morphology and DNA content are hallmarks of aggressive cancer cells, and the research proposed here will contribute to a better understanding of how these alterations arise. ..
  47. Genetic determinants of total cholesterol levels in American Indians
    JOHANNA K DISTEFANO; Fiscal Year: 2013
  48. Roles of the Unfolded Protein Response in Cell Cycle
    MAHO R NIWA; Fiscal Year: 2013
    ..Thus, knowledge of the cellular mechanisms assuring the maintenance and transmission of a functionally competent ER will be invaluable towards the development of previously unrecognized strategies for therapeutic intervention. ..
  49. Genome-Wide Mapping of Chromosomal Proteins in Drosophilia
    Gary H Karpen; Fiscal Year: 2011
    ..In addition, the data and analysis are highly likely to provide information critical to understanding the roles of chromatin in human cells and diseases. ..
  50. Transgenerational exposures as modifiers of host defense against infection
    B Paige Lawrence; Fiscal Year: 2013
  51. Sodium Channels and Cardiac Arrhythmias
    Isabelle Deschenes; Fiscal Year: 2013
    ..This is crucial for cardiologists to select family members who will more likely benefit from an expensive and risky therapy, the implanted defibrillator. A gene therapy approach will also be developed to treat arrhythmias. ..
  52. Evolutionary and functional diversification of chromatin proteins
    MIA TAUNA LEVINE; Fiscal Year: 2013
    ..By identifying the biological causes and consequences of chromatin protein innovation, these studies will provide novel insights into how rapid evolution renders our genome vulnerable to epigenetic disease and infertility. ..
  53. Planning Grant for Genome-Wide Association Study of Craniofacial Microsomia
    JACQUELINE R contact STARR; Fiscal Year: 2010
    ..It will also enable further research on the etiology and health care outcomes in patients with craniofacial disorders. ..
  54. Mammalian Centromere Assembly
    Don W Cleveland; Fiscal Year: 2013
  55. Endoplasmic Reticulum Stress in Retinal Degeneration
    Jonathan Lin; Fiscal Year: 2013
    ..These studies may also provide new therapeutic targets to prevent blindness. ..
  56. Initiation of Epigenetic Transcriptional Regulation
    Sundeep Kalantry; Fiscal Year: 2011
    ..This reversibility makes epigenetic changes, including those we propose to identify, potentially amenable to manipulation and therapeutic intervention. ..
  57. Regulation Of Cortical Neurogenesis By Apical Complex Proteins
    Seonhee Kim; Fiscal Year: 2013
  58. Stochastic Models of Cell Cycle Regulation in Eukaryotes
    John J Tyson; Fiscal Year: 2013
    ..Hence, a validated stochastic model of the eukaryotic cell cycle is essential to progress in the field of molecular systems biology. ..
  59. Transmissibility of Neurodegenerative Diseases
    DMITRY Y GOLDGABER; Fiscal Year: 2011
    ..It will also open new approaches and new opportunities in studying the pathological processes and in the development of new treatments of neurodegenerative diseases. ..
  60. Genetic Analysis of Host Specificity in Schistosoma mansoni
    Tim J Anderson; Fiscal Year: 2013
  61. Modeling TAR Microdeletion Syndrome in Mouse
    Christa Lese Martin; Fiscal Year: 2013
    ..Our novel experimental approach can serve as a general model to quickly and efficiently identify genomic variation that is relevant to human disease. ..
  62. Architectural Epigenetics of Embryonic and Induced Pluripotent Stem Cells
    Gary S Stein; Fiscal Year: 2010
    Thomas Glaser; Fiscal Year: 2004
  64. Structural mechanism of DNA segregation by the pSK41 par system
    Maria Schumacher; Fiscal Year: 2010
    ..Thus, understanding the structural basis for DNA segregation by this par system will provide several points of potential therapeutic intervention against pSK41 harboring multidrug resistant S. aureus strains. ..
  65. The pigmentary system: securing a place in the sun
    Andrzej Slominski; Fiscal Year: 2009
    ..Methodist Healthcare accredited by the ACCME to provide continuing medical education for physicians decided to co-sponsor this meeting and designated this educational activity for a maximum of 26 AMA PRA Category 1 Credits. ..
  66. Genetic Characterization of Essential Hyperhidrosis
    Gary Swergold; Fiscal Year: 2003
    ..Most importantly, understanding the etiology of EH may open a new window of understanding into the organization and regulation of the autonomic nervous system, and the regulation of body temperature and sweating. ..
    Steve Sommer; Fiscal Year: 1999
    ..factor IX gene in eight great apes and Old World monkeys the same in each lineage?; and (viii) Are the amino acids conserved in factor IX during nonmammalian evolution the same amino acids that are mutated in humans with hemophilia B? ..
    Richard Boles; Fiscal Year: 2002
    ..An extensive amount of clinical and laboratory data will be collected in all patients, allowing for the comparison of CVS sufferers with and without mtDNA mutations. ..
    Glenys Thomson; Fiscal Year: 2000
    ..A framework for genetic counselling of HLA associated, and other complex diseases, will be developed. The results of our studies are generally applicable to the mapping and characterization of complex human genetic traits. ..
    Carolyn Kelly; Fiscal Year: 2003
    ..These studies will provide important new information regarding genes that regulate the magnitude of lymphocyte responses and susceptibility/resistance to autoimmune disease. ..
    Geraldine Mineau; Fiscal Year: 2006
    ..As study groups are enrolled, DNA samples may be collected and pilot projects initiated; these include sib-pair studies and candidate-gene analysis funded by the Huntsman Cancer Institute and the University of Colorado Cancer Center. ..
    Keith Latham; Fiscal Year: 2004
    ..These studies are relevant to problems of human infertility and a variety of diseases involving inappropriate epigenetic regulation of gene function. ..
    Elan Louis; Fiscal Year: 1999
    ..Drs. W. Allen Hauser, Ruth Ottman, Richard Mayeux and Stanley Fahn, all internationally recognized either within the areas of Neuroepidemiology or Movement Disorders, will provide invaluable guidance in these studies. ..