endosomes

Summary

Summary: Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.

Top Publications

  1. Winter J, Höpfner S, Korn K, Farnung B, Bradshaw C, Marsico G, et al. Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat Cell Biol. 2012;14:666-76 pubmed publisher
    Apically enriched Rab11-positive recycling endosomes (Rab11-REs) are important for establishing and maintaining epithelial polarity. Yet, little is known about the molecules controlling trafficking of Rab11-REs in an epithelium in vivo...
  2. Puri C, Renna M, Bento C, Moreau K, Rubinsztein D. Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell. 2013;154:1285-99 pubmed publisher
    ..We observed that mATG9 traffics from the plasma membrane to recycling endosomes in carriers that appear to be routed differently from ATG16L1-containing vesicles, another source of ..
  3. Seaman M, Gautreau A, Billadeau D. Retromer-mediated endosomal protein sorting: all WASHed up!. Trends Cell Biol. 2013;23:522-8 pubmed publisher
    ..Studies now show that retromer mediates the recruitment of the WASH complex and its regulators to endosomes. In this review, recent progress in understanding the role of the WASH complex along with retromer in endosomal ..
  4. Zhou B, Cai Q, Xie Y, Sheng Z. Snapin recruits dynein to BDNF-TrkB signaling endosomes for retrograde axonal transport and is essential for dendrite growth of cortical neurons. Cell Rep. 2012;2:42-51 pubmed publisher
    Neurotrophin signaling is crucial for neuron growth. While the "signaling endosomes" hypothesis is one of the accepted models, the molecular machinery that drives retrograde axonal transport of TrkB signaling endosomes is largely unknown...
  5. Helfer E, Harbour M, Henriot V, Lakisic G, Sousa Blin C, Volceanov L, et al. Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer. Biol Cell. 2013;105:191-207 pubmed publisher
    ..Wiskott-Aldrich syndrome protein and scar homolog (WASH) complex is the major Arp2/3 activator at the surface of endosomes. The branched actin network, that the WASH complex induces, contributes to cargo sorting and scission of ..
  6. D az Salinas M, Silva Ayala D, L pez S, Arias C. Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell. J Virol. 2014;88:4389-402 pubmed publisher
    ..tested if the intracellular trafficking of BRV UK was the same as that of RRV, which is known to reach maturing endosomes (MEs) to infect the cell...
  7. Higuchi Y, Ashwin P, Roger Y, Steinberg G. Early endosome motility spatially organizes polysome distribution. J Cell Biol. 2014;204:343-57 pubmed publisher
    Early endosomes (EEs) mediate protein sorting, and their cytoskeleton-dependent motility supports long-distance signaling in neurons...
  8. Fearnley G, Smith G, Odell A, Latham A, Wheatcroft S, Harrison M, et al. Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells. Methods Enzymol. 2014;535:265-92 pubmed publisher
    ..Each of these assays has been exemplified with studies performed in our laboratories. In conclusion, we describe necessary techniques for studying the role of VEGF-A in endothelial cell function. ..
  9. Mellman I, Yarden Y. Endocytosis and cancer. Cold Spring Harb Perspect Biol. 2013;5:a016949 pubmed publisher
    ..of cell-surface proteins, such as receptors for cytokines and adhesion components, in cytoplasmic vesicles (endosomes)...

More Information

Publications73

  1. Maldonado Baez L, Donaldson J. Hook1, microtubules, and Rab22: mediators of selective sorting of clathrin-independent endocytic cargo proteins on endosomes. Bioarchitecture. 2013;3:141-6 pubmed publisher
    ..of trafficking to lysosomes for degradation or follow a pathway where they are routed directly to the recycling endosomes for return to the PM...
  2. Traub L, Bonifacino J. Cargo recognition in clathrin-mediated endocytosis. Cold Spring Harb Perspect Biol. 2013;5:a016790 pubmed publisher
    ..Related sorting events occur at other endosomal sorting stations. ..
  3. Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, et al. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol. 2013;203:115-28 pubmed publisher
    ..After invasion, ubiquitin is conjugated to host cellular proteins in endosomes that contain Salmonella or transfection reagent-coated latex (polystyrene) beads, which mimic invading bacteria...
  4. Hesketh G, Pérez Dorado I, Jackson L, Wartosch L, Schäfer I, Gray S, et al. VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface. Dev Cell. 2014;29:591-606 pubmed publisher
    ..by its direct interaction with VPS29, a subunit of the retromer complex, which is involved in trafficking from endosomes to the TGN and the cell surface...
  5. Bielska E, Schuster M, Roger Y, Berepiki A, Soanes D, Talbot N, et al. Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes. J Cell Biol. 2014;204:989-1007 pubmed publisher
    ..We conclude that Hok1 is part of an evolutionarily conserved protein complex that regulates bidirectional EE trafficking by controlling attachment of both kinesin-3 and dynein. ..
  6. Hehnly H, Doxsey S. Rab11 endosomes contribute to mitotic spindle organization and orientation. Dev Cell. 2014;28:497-507 pubmed publisher
    During interphase, Rab11-GTPase-containing endosomes recycle endocytic cargo. However, little is known about Rab11 endosomes in mitosis...
  7. Alpy F, Rousseau A, Schwab Y, Legueux F, Stoll I, Wendling C, et al. STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER. J Cell Sci. 2013;126:5500-12 pubmed publisher
    ..lipid transfer domain-3 (STARD3) and STARD3 N-terminal like (STARD3NL) in the formation of MCSs involving late-endosomes (LEs). We demonstrate that both STARD3 and STARD3NL create MCSs between LEs and the endoplasmic reticulum (ER)...
  8. Paulsel A, Merz A, Nickerson D. Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast. J Biol Chem. 2013;288:18162-71 pubmed publisher
    ..Microscopy and overexpression experiments demonstrate that Vps9 and Muk1 have distinct localization determinants. These experiments establish Muk1 as the second Rab5 GEF in budding yeast. ..
  9. Shi A, Liu O, Koenig S, Banerjee R, Chen C, Eimer S, et al. RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate. Proc Natl Acad Sci U S A. 2012;109:E2306-15 pubmed publisher
    ..CNT-1 binds to RAB-10 through its C-terminal ankyrin repeats and colocalizes with RAB-10 and ARF-6 on recycling endosomes in vivo...
  10. Danson C, Brown E, Hemmings O, McGough I, Yarwood S, Heesom K, et al. SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome. J Cell Sci. 2013;126:4885-99 pubmed publisher
    ..degradation arising from a defect in movement of newly internalised EGF-receptor-labelled vesicles into early endosomes. Besides a phosphatidylinositol 3-phosphate- and PX-domain-dependent association to early endosomes, SNX15 also ..
  11. Derivery E, Helfer E, Henriot V, Gautreau A. Actin polymerization controls the organization of WASH domains at the surface of endosomes. PLoS ONE. 2012;7:e39774 pubmed publisher
    Sorting of cargoes in endosomes occurs through their selective enrichment into sorting platforms, where transport intermediates are generated...
  12. Deliu E, Brailoiu G, Mallilankaraman K, Wang H, Madesh M, Undieh A, et al. Intracellular endothelin type B receptor-driven Ca2+ signal elicits nitric oxide production in endothelial cells. J Biol Chem. 2012;287:41023-31 pubmed publisher
    ..Endothelin-1 acts in an intracrine fashion on endolysosomal ET(B) to induce nitric oxide formation, thus modulating endothelial function. ..
  13. Xu J, Teslaa T, Wu T, Chiou P, Teitell M, Weiss S. Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells. Nano Lett. 2012;12:5669-72 pubmed publisher
    ..We conjugated tubulin to QDs and applied the emerging method of photothermal nanoblade to deliver QD-tubulin conjugates into live Hela cells. This method will open new opportunities for cytosolic targeting of QDs in live cells. ..
  14. Jean S, Kiger A. Coordination between RAB GTPase and phosphoinositide regulation and functions. Nat Rev Mol Cell Biol. 2012;13:463-70 pubmed publisher
  15. Cai B, Giridharan S, Zhang J, Saxena S, Bahl K, Schmidt J, et al. Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes. J Biol Chem. 2013;288:30172-80 pubmed publisher
    ..vesiculation allows us to assess the ability of each protein to vesiculate MICAL-L1-decorated tubular recycling endosomes (TREs)...
  16. Scheffer K, Popa Wagner R, Florin L. Isolation and characterization of pathogen-bearing endosomes enable analysis of endosomal escape and identification of new cellular cofactors of infection. Methods Mol Biol. 2013;1064:101-13 pubmed publisher
    ..toxins, enter their target cells by endocytosis leading to accumulation of pathogenic and cellular proteins in endosomes. Here, we present detailed experimental instructions on isolation of endosomes after virus infection and their ..
  17. Pashkova N, Gakhar L, Winistorfer S, Sunshine A, Rich M, Dunham M, et al. The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes. Dev Cell. 2013;25:520-33 pubmed publisher
    ..These data suggest that Bro1 and other Bro1 family members function in parallel with ESCRT-0 to recognize and sort Ub-cargoes...
  18. Choy R, Cheng Z, Schekman R. Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid ? (A?) production in the trans-Golgi network. Proc Natl Acad Sci U S A. 2012;109:E2077-82 pubmed publisher
    ..The intracellular location of A? production-endosomes or the trans-Golgi network (TGN)-remains uncertain...
  19. Nakatsu Y, Ma X, Seki F, Suzuki T, Iwasaki M, Yanagi Y, et al. Intracellular transport of the measles virus ribonucleoprotein complex is mediated by Rab11A-positive recycling endosomes and drives virus release from the apical membrane of polarized epithelial cells. J Virol. 2013;87:4683-93 pubmed publisher
    ..was transported in a manner dependent on the microtubule network and together with Rab11A-containing recycling endosomes. The RNP complex was accumulated at the apical membrane and the apical recycling compartment...
  20. Reed S, Hodgson L, Song S, May M, Kelly E, McCaffrey M, et al. A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes. J Cell Sci. 2013;126:1931-41 pubmed publisher
    ..These enlarged vesicles contained markers of early endosomes and were rapidly filled by GLUT4 and transferrin undergoing endocytosis from the plasma membrane...
  21. Schiel J, Childs C, Prekeris R. Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance. Trends Cell Biol. 2013;23:319-27 pubmed publisher
    ..Furthermore, new evidence suggests that endosomes may have additional roles in post-mitotic cellular events such as midbody inheritance and degradation...
  22. Seidel C, Moreno Velásquez S, Riquelme M, Fischer R. Neurospora crassa NKIN2, a kinesin-3 motor, transports early endosomes and is required for polarized growth. Eukaryot Cell. 2013;12:1020-32 pubmed publisher
    ..To test whether the spots represented early endosomes, the Rab5 GTPase YPT52 was used as an endosomal marker. NKIN2 colocalized with YPT52...
  23. Kennedy B, Charman M, Karten B. Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1. J Lipid Res. 2012;53:2632-42 pubmed publisher
    ..Transport assays in semi-permeabilized cells showed nonvesicular cholesterol trafficking directly from endosomes to mitochondria that did not require cytosolic transport proteins but that was reduced in the absence of NPC2...
  24. Cabrera M, Arlt H, Epp N, Lachmann J, Griffith J, Perz A, et al. Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis. J Biol Chem. 2013;288:5166-75 pubmed publisher
    Transport along the endolysosomal system requires multiple fusion events at early and late endosomes. Deletion of several endosomal fusion factors, including the Vac1 tether and the Class C core vacuole/endosome tethering (CORVET) ..
  25. Balderhaar H, Ungermann C. CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion. J Cell Sci. 2013;126:1307-16 pubmed publisher
    ..Here, we focus on the mechanism of membrane fusion at endosomes, vacuoles and lysosomes, and in particular on the role of the two homologous tethering complexes called CORVET ..
  26. Wu J, Herman M, Liu L, Simoes S, Acker C, Figueroa H, et al. Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem. 2013;288:1856-70 pubmed publisher
    ..These data provide support for observations that tauopathy can spread trans-synaptically in vivo, via cell-to-cell transfer...
  27. Chatterjee B, Smed Sorensen A, Cohn L, Chalouni C, Vandlen R, Lee B, et al. Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells. Blood. 2012;120:2011-20 pubmed publisher
    ..identical antigens conjugated with antibodies against different DC receptors that are targeted to early or late endosomes at distinct efficiencies...
  28. Lee S, Uchida Y, Emoto K, Umeda M, Kuge O, Taguchi T, et al. Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis. Genes Cells. 2012;17:728-36 pubmed publisher
    ..PS also localizes in the membranes of endocytic organelles, such as recycling endosomes (REs)...
  29. Chen W, Kawasaki N, Nycholat C, Han S, Pilotte J, Crocker P, et al. Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169. PLoS ONE. 2012;7:e39039 pubmed publisher
    ..Together, these data provide insights into the potential of cell-specific targeting and delivery of antigens to intracellular organelles of macrophages using Sn-ligand decorated liposomal nanoparticles...
  30. van Weering J, Sessions R, Traer C, Kloer D, Bhatia V, Stamou D, et al. Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J. 2012;31:4466-80 pubmed publisher
    ..Our data provide insight into the molecular mechanism that generates and organizes the tubular endosomal network...
  31. Beas A, Taupin V, Teodorof C, Nguyen L, Garcia Marcos M, Farquhar M. G?s promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin). Mol Biol Cell. 2012;23:4623-34 pubmed publisher
    ..that Akt cell survival signaling via the epidermal growth factor receptor (EGFR) occurs from APPL early endosomes that mature into early EEA1 endosomes. Less is known about receptor signaling from EEA1 endosomes...
  32. Padilla Parra S, Matos P, Kondo N, Marin M, Santos N, Melikyan G. Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes. Proc Natl Acad Sci U S A. 2012;109:17627-32 pubmed publisher
    ..Currently, the pH dynamics in virus-carrying endosomes and the relationship between acidification and viral fusion are poorly characterized...
  33. Mainou B, Dermody T. Transport to late endosomes is required for efficient reovirus infection. J Virol. 2012;86:8346-58 pubmed publisher
    ..In this study, we found that reovirus particles traffic through early, late, and recycling endosomes during cell entry...
  34. Duleh S, Welch M. Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complex. Cytoskeleton (Hoboken). 2012;69:1047-58 pubmed publisher
    ..We observed that subdomains of early/sorting endosomes associated with dynamic WASH and filamentous actin, and ?5-integrins trafficked through this population of ..
  35. Vistein R, Puthenveedu M. Reprogramming of G protein-coupled receptor recycling and signaling by a kinase switch. Proc Natl Acad Sci U S A. 2013;110:15289-94 pubmed publisher
    ..Such flexible reprogramming might provide a versatile method for rapidly modulating cellular responses to extracellular signaling. ..
  36. Zeigerer A, Gilleron J, Bogorad R, Marsico G, Nonaka H, Seifert S, et al. Rab5 is necessary for the biogenesis of the endolysosomal system in vivo. Nature. 2012;485:465-70 pubmed publisher
    ..Loss of Rab5 below this threshold caused a marked reduction in the number of early endosomes, late endosomes and lysosomes, associated with a block of low-density lipoprotein endocytosis...
  37. Sandri C, Caccavari F, Valdembri D, Camillo C, Veltel S, Santambrogio M, et al. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res. 2012;22:1479-501 pubmed publisher
    ..selective endocytosis of ligand-bound/active ?1 integrins and then causes the translocation of R-Ras to early endosomes. Here, the R-Ras/RIN2/Rab5 signaling module activates Rac1-dependent cell adhesion via TIAM1, a Rac GEF that ..
  38. Oku S, Takahashi N, Fukata Y, Fukata M. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. J Biol Chem. 2013;288:19816-29 pubmed publisher
    ..Stimulated emission depletion microscopy revealed that Ncdn was localized to Rab5-positive early endosomes in a palmitoylation-dependent manner, where DHHC1/10 (z1/11) were also distributed...
  39. Kawamura N, Sun Wada G, Aoyama M, Harada A, Takasuga S, Sasaki T, et al. Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012;3:1071 pubmed publisher
    ..The endosomes of visceral endoderm cells are delivered via a unique microautophagy-like process to the apical vacuole, a large ..
  40. Egan M, McClintock M, Reck Peterson S. Microtubule-based transport in filamentous fungi. Curr Opin Microbiol. 2012;15:637-45 pubmed publisher
    ..microtubules in nuclear positioning is well studied, but recent work has expanded the range of cargos to include endosomes, messenger RNA, secretory vesicles, peroxisomes, and nuclear pore complexes, reflecting the diversity of ..
  41. Yousefian J, Troost T, Grawe F, Sasamura T, FORTINI M, Klein T. Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila. J Cell Sci. 2013;126:1583-94 pubmed publisher
    ..A crucial event during maturation of endosomes is the replacement of the early organiser Rab5 with the late organiser Rab7 in a process called Rab conversion...
  42. Taguchi T. Emerging roles of recycling endosomes. J Biochem. 2013;153:505-10 pubmed publisher
    ..Recycling to the PM can occur from early endosomes. However, many cells have a distinct subpopulation of endosomes that have a mildly acidic pH of 6...
  43. Seaman M. The retromer complex - endosomal protein recycling and beyond. J Cell Sci. 2012;125:4693-702 pubmed publisher
    ..In this Commentary, I will highlight recent advances in the understanding of retromer-mediated endosomal protein sorting and discuss how retromer contributes to a diverse set of physiological processes...
  44. Bohdanowicz M, Grinstein S. Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis. Physiol Rev. 2013;93:69-106 pubmed publisher
    ..This is followed by a detailed analysis of the critical functions of phospholipids in the internalization processes and in the maturation of the resulting vesicles and vacuoles as they progress along the endo-lysosomal pathway...
  45. Zeng X, Carlin C. Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells. J Virol. 2013;87:2307-19 pubmed publisher
    ..Autophagic cargo is sequestered in double-membrane structures called autophagosomes that fuse with endosomes to form amphisomes which then deliver their content to lysosomes...
  46. Kural C, Tacheva Grigorova S, Boulant S, Cocucci E, Baust T, Duarte D, et al. Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers. Cell Rep. 2012;2:1111-9 pubmed publisher
    Clathrin/AP1- and clathrin/AP3-coated vesicular carriers originate from endosomes and the trans-Golgi network...
  47. Mitchell D, Blasier K, Jeffery E, Ross M, Pullikuth A, Suo D, et al. Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. J Neurosci. 2012;32:15495-510 pubmed publisher
    The retrograde transport of Trk-containing endosomes from the axon to the cell body by cytoplasmic dynein is necessary for axonal and neuronal survival...
  48. Varsano T, Taupin V, Guo L, Baterina O, Farquhar M. The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA. PLoS ONE. 2012;7:e49227 pubmed publisher
    ..with GIPC and its binding partner APPL, an activator of Akt signaling found on APPL signaling endosomes. GIPC depletion by siRNA disturbed trafficking of LPA(1) to EEA1 early endosomes and promoted LPA(1) mediated ..
  49. Yu Y, Kita A, Udo M, Katayama Y, Shintani M, Park K, et al. Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast. PLoS ONE. 2012;7:e45324 pubmed publisher
    ..The Sip1-green fluorescent protein (GFP) co-localized with Apm1-mCherry at Golgi/endosomes, and Sip1 physically interacted with each subunit of the AP-1 complex...
  50. Hirst J, Irving C, Borner G. Adaptor protein complexes AP-4 and AP-5: new players in endosomal trafficking and progressive spastic paraplegia. Traffic. 2013;14:153-64 pubmed publisher
    ..The unexpected phenotypic parallels between AP-4 and AP-5 patients may in turn suggest a functional relationship of the two APs in vesicle trafficking. ..
  51. Schneider M, Troost T, Grawe F, Martinez Arias A, Klein T. Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome. J Cell Sci. 2013;126:645-56 pubmed publisher
    ..In addition, electron microscopy of lgd cells revealed that they contain enlarged multi-vesicular bodies. The presented results further elucidate the mechanism of uncontrolled Notch activation upon derailed endocytosis...
  52. Qiu R, Zhang J, Xiang X. Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivo. J Biol Chem. 2013;288:2271-80 pubmed publisher
    ..motor cytoplasmic dynein is responsible for the intracellular movements of many organelles, including nuclei and endosomes. The dynein heavy chain contains a C-terminal motor domain and an N-terminal tail domain...
  53. Deane E, Ilie A, Sizdahkhani S, Das Gupta M, Orlowski J, McKinney R. Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J Neurosci. 2013;33:595-610 pubmed publisher
    ..Recycling endosomes perform activity-dependent transport of AMPA receptors (AMPARs) and lipids to the postsynaptic membrane, ..
  54. Tornieri K, Zlatic S, Mullin A, Werner E, Harrison R, L hernault S, et al. Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes. Hum Mol Genet. 2013;22:5215-28 pubmed publisher
    ..mutations prevent interaction between VIPAS39/SPE-39 and Vps33b, some mutants fragment VIPAS39/SPE-39-positive endosomes, but all mutants alter the subcellular localization of Vps33b to VIPAS39/SPE-39-positive endosomes...
  55. Babst M, Odorizzi G. The balance of protein expression and degradation: an ESCRTs point of view. Curr Opin Cell Biol. 2013;25:489-94 pubmed publisher
    ..Increasing evidence also points to ESCRTs regulating RNA interference (RNAi) pathways that control translation. ..
  56. Takatsu H, Katoh Y, Ueda T, Waguri S, Murayama T, Takahashi S, et al. Mitosis-coupled, microtubule-dependent clustering of endosomal vesicles around centrosomes. Cell Struct Funct. 2013;38:31-41 pubmed
    ..Our observations indicate that ERC clustering around centrosomes plays a fundamental role in restricting membrane delivery to the plasma membrane during early mitotic phases, when the cell surface-to-volume ratio reaches its minimum...
  57. van der Kant R, Zondervan I, Janssen L, Neefjes J. Cholesterol-binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1. J Lipid Res. 2013;54:2153-65 pubmed publisher
    ..source for cellular cholesterol is internalized lipoprotein particles that are transported toward acidic late endosomes (LE) and lysosomes...
  58. Hunt S, Townley A, Danson C, Cullen P, Stephens D. Microtubule motors mediate endosomal sorting by maintaining functional domain organization. J Cell Sci. 2013;126:2493-501 pubmed publisher
    ..Sorting nexins (SNXs) are central to the organization and function of endosomes. These proteins can actively shape endosomal membranes and couple directly or indirectly to the minus-end ..
  59. Cohn L, Chatterjee B, Esselborn F, Smed Sorensen A, Nakamura N, Chalouni C, et al. Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation. J Exp Med. 2013;210:1049-63 pubmed publisher
    ..As expected, BDCA3(+) DCs were superior at cross presentation of antigens delivered to late endosomes and lysosomes by uptake of anti-DEC205 antibody conjugated to antigen...
  60. Jean S, Cox S, Schmidt E, Robinson F, Kiger A. Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Mol Biol Cell. 2012;23:2723-40 pubmed publisher
    ..functions as a guanine nucleotide exchange factor that promotes Rab21 GTPase activation associated with PI(3)P endosomes. Of importance, Sbf, Mtm, and Rab21 function together, along with Rab11-mediated endosomal trafficking, to ..
  61. Bond L, Arden S, Kendrick Jones J, Buss F, Sellers J. Dynamic exchange of myosin VI on endocytic structures. J Biol Chem. 2012;287:38637-46 pubmed publisher
    ..uptake pathway, both during the early stages of clathrin-mediated uptake and in later transport to/from early endosomes. This study uses fluorescence recovery after photobleaching (FRAP) to examine the turnover rate of myosin VI ..
  62. Stewart R, Teng H, Wilkinson R. "Late" macroendosomes and acidic endosomes in vertebrate motor nerve terminals. J Comp Neurol. 2012;520:4275-93 pubmed publisher
    ..Others (at least 15/1,960 or 1%) fuse or closely associate with a second class of endosomes that take up acidophilic dyes (acidic endosomes [AEs])...
  63. Itakura E, Kishi Itakura C, Mizushima N. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell. 2012;151:1256-69 pubmed publisher
    ..These findings reveal a mechanism by which the SNARE protein is available to the completed autophagosome...
  64. Contento A, Bassham D. Structure and function of endosomes in plant cells. J Cell Sci. 2012;125:3511-8 pubmed
    b>Endosomes are a heterogeneous collection of organelles that function in the sorting and delivery of internalized material from the cell surface and the transport of materials from the Golgi to the lysosome or vacuole...