weibel palade bodies

Summary

Summary: Rod-shaped storage granules for VON WILLEBRAND FACTOR specific to endothelial cells.

Top Publications

  1. Romani de Wit T, Rondaij M, Hordijk P, Voorberg J, van Mourik J. Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies. Arterioscler Thromb Vasc Biol. 2003;23:755-61 pubmed
  2. Michaux G, Cutler D. How to roll an endothelial cigar: the biogenesis of Weibel-Palade bodies. Traffic. 2004;5:69-78 pubmed
    ..Von Willebrand's disease, usually caused by mutations within VWF, has provided many of the insights into the way in which VWF drives the formation of these organelles...
  3. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt J, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood. 2004;103:4150-6 pubmed
  4. Hannah M, Hume A, Arribas M, Williams R, Hewlett L, Seabra M, et al. Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type. J Cell Sci. 2003;116:3939-48 pubmed
    ..We conclude that a lumenal cargo protein drives the recruitment of Rab27a to the organelle membrane by a novel mechanism that is indirect, maturation-dependent and cell-type independent...
  5. Manneville J, Etienne Manneville S, Skehel P, Carter T, Ogden D, Ferenczi M. Interaction of the actin cytoskeleton with microtubules regulates secretory organelle movement near the plasma membrane in human endothelial cells. J Cell Sci. 2003;116:3927-38 pubmed
    ..The results show that the dynamics of endothelial secretory organelles close to the plasma membrane are controlled by the opposing roles of the microtubule and actin cytoskeletal transport systems...
  6. Knop M, Aareskjold E, Bode G, Gerke V. Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. EMBO J. 2004;23:2982-92 pubmed
    ..This indicates that distinct mechanisms underlie the acute secretion of vWF and tPA, enabling endothelial cells to fine-regulate the release of thrombogenic and fibrinolytic factors...
  7. Michaux G, Hewlett L, Messenger S, Goodeve A, Peake I, Daly M, et al. Analysis of intracellular storage and regulated secretion of 3 von Willebrand disease-causing variants of von Willebrand factor. Blood. 2003;102:2452-8 pubmed
    ..Studies of pseudo-WPB formation in this system thus yield insights into the structure-function relationships underpinning the ability of VWF to form functional WPBs...
  8. Michaux G, Abbitt K, Collinson L, Haberichter S, Norman K, Cutler D. The physiological function of von Willebrand's factor depends on its tubular storage in endothelial Weibel-Palade bodies. Dev Cell. 2006;10:223-32 pubmed
    ..Thus, a 100-fold compaction of VWF into tubules determines the unique shape of Weibel-Palade bodies and is critical to this protein's hemostatic function...
  9. Hannah M, Williams R, Kaur J, Hewlett L, Cutler D. Biogenesis of Weibel-Palade bodies. Semin Cell Dev Biol. 2002;13:313-24 pubmed
    ..We are only just beginning to understand the way in which these three proteins come together to form mature WPBs...
  10. Harrison Lavoie K, Michaux G, Hewlett L, Kaur J, Hannah M, Lui Roberts W, et al. P-selectin and CD63 use different mechanisms for delivery to Weibel-Palade bodies. Traffic. 2006;7:647-62 pubmed
    ..These different mechanisms of recruitment lead to the presence of distinct immature and mature populations of WPB in human umbilical vein endothelial cells (HUVEC)...

Detail Information

Publications62

  1. Romani de Wit T, Rondaij M, Hordijk P, Voorberg J, van Mourik J. Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies. Arterioscler Thromb Vasc Biol. 2003;23:755-61 pubmed
  2. Michaux G, Cutler D. How to roll an endothelial cigar: the biogenesis of Weibel-Palade bodies. Traffic. 2004;5:69-78 pubmed
    ..Von Willebrand's disease, usually caused by mutations within VWF, has provided many of the insights into the way in which VWF drives the formation of these organelles...
  3. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt J, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood. 2004;103:4150-6 pubmed
  4. Hannah M, Hume A, Arribas M, Williams R, Hewlett L, Seabra M, et al. Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type. J Cell Sci. 2003;116:3939-48 pubmed
    ..We conclude that a lumenal cargo protein drives the recruitment of Rab27a to the organelle membrane by a novel mechanism that is indirect, maturation-dependent and cell-type independent...
  5. Manneville J, Etienne Manneville S, Skehel P, Carter T, Ogden D, Ferenczi M. Interaction of the actin cytoskeleton with microtubules regulates secretory organelle movement near the plasma membrane in human endothelial cells. J Cell Sci. 2003;116:3927-38 pubmed
    ..The results show that the dynamics of endothelial secretory organelles close to the plasma membrane are controlled by the opposing roles of the microtubule and actin cytoskeletal transport systems...
  6. Knop M, Aareskjold E, Bode G, Gerke V. Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. EMBO J. 2004;23:2982-92 pubmed
    ..This indicates that distinct mechanisms underlie the acute secretion of vWF and tPA, enabling endothelial cells to fine-regulate the release of thrombogenic and fibrinolytic factors...
  7. Michaux G, Hewlett L, Messenger S, Goodeve A, Peake I, Daly M, et al. Analysis of intracellular storage and regulated secretion of 3 von Willebrand disease-causing variants of von Willebrand factor. Blood. 2003;102:2452-8 pubmed
    ..Studies of pseudo-WPB formation in this system thus yield insights into the structure-function relationships underpinning the ability of VWF to form functional WPBs...
  8. Michaux G, Abbitt K, Collinson L, Haberichter S, Norman K, Cutler D. The physiological function of von Willebrand's factor depends on its tubular storage in endothelial Weibel-Palade bodies. Dev Cell. 2006;10:223-32 pubmed
    ..Thus, a 100-fold compaction of VWF into tubules determines the unique shape of Weibel-Palade bodies and is critical to this protein's hemostatic function...
  9. Hannah M, Williams R, Kaur J, Hewlett L, Cutler D. Biogenesis of Weibel-Palade bodies. Semin Cell Dev Biol. 2002;13:313-24 pubmed
    ..We are only just beginning to understand the way in which these three proteins come together to form mature WPBs...
  10. Harrison Lavoie K, Michaux G, Hewlett L, Kaur J, Hannah M, Lui Roberts W, et al. P-selectin and CD63 use different mechanisms for delivery to Weibel-Palade bodies. Traffic. 2006;7:647-62 pubmed
    ..These different mechanisms of recruitment lead to the presence of distinct immature and mature populations of WPB in human umbilical vein endothelial cells (HUVEC)...
  11. Blagoveshchenskaya A, Hannah M, Allen S, Cutler D. Selective and signal-dependent recruitment of membrane proteins to secretory granules formed by heterologously expressed von Willebrand factor. Mol Biol Cell. 2002;13:1582-93 pubmed
    ..e., vWF), the active recruitment of at least one component of the pseudogranule membrane (i.e., P-selectin) is dependent on residues of P-selectin that are cytosolic and therefore unable to directly interact with vWF...
  12. Metcalf D, Nightingale T, Zenner H, Lui Roberts W, Cutler D. Formation and function of Weibel-Palade bodies. J Cell Sci. 2008;121:19-27 pubmed
    ..Following recruitment of cargo at the TGN, there is a second wave of recruitment that delivers integral and peripheral membrane proteins to WPBs, some of which is AP3 dependent...
  13. Huang R, Wang Y, Roth R, Yu X, Purvis A, Heuser J, et al. Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor. Proc Natl Acad Sci U S A. 2008;105:482-7 pubmed publisher
    ..2 units per turn. The symmetry and location of interdomain contacts suggest that decreasing pH along the secretory pathway coordinates the disulfide-linked assembly of VWF multimers with their tubular packaging...
  14. Lui Roberts W, Collinson L, Hewlett L, Michaux G, Cutler D. An AP-1/clathrin coat plays a novel and essential role in forming the Weibel-Palade bodies of endothelial cells. J Cell Biol. 2005;170:627-36 pubmed
    ..We propose that, in contrast to other secretory granules, cargo aggregation alone is not sufficient to form immature WPBs and that an external scaffold that contains AP-1 and clathrin is essential...
  15. Dole V, Bergmeier W, Mitchell H, Eichenberger S, Wagner D. Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood. 2005;106:2334-9 pubmed
    ..We conclude that the presence of activated platelets in circulation promotes acute inflammation by stimulating secretion of Weibel-Palade bodies and P-selectin-mediated leukocyte rolling...
  16. Romani de Wit T, de Leeuw H, Rondaij M, de Laaf R, Sellink E, Brinkman H, et al. Von Willebrand factor targets IL-8 to Weibel-Palade bodies in an endothelial cell line. Exp Cell Res. 2003;286:67-74 pubmed
    ..Live cell imaging revealed that the number of VWF-GFP-containing granules decreased upon cell stimulation. These observations indicate that VWF plays an active role in sequestering IL-8 into Weibel-Palade bodies...
  17. Zenner H, Collinson L, Michaux G, Cutler D. High-pressure freezing provides insights into Weibel-Palade body biogenesis. J Cell Sci. 2007;120:2117-25 pubmed
    ..The use of high-pressure freezing was vital in this study and it suggests that this technique might prove essential to any detailed characterisation of organelle biogenesis...
  18. Ochoa C, Wu S, Stevens T. New developments in lung endothelial heterogeneity: Von Willebrand factor, P-selectin, and the Weibel-Palade body. Semin Thromb Hemost. 2010;36:301-8 pubmed publisher
    ..This information is considered in the context of vasculitis and pneumonia, two pathophysiological processes to which the stimulated secretion of VWF and P-selectin contribute...
  19. Manconi F, Markham R, Fraser I. Culturing endothelial cells of microvascular origin. Methods Cell Sci. 2000;22:89-99 pubmed
    ..Cell adhesion molecules such as ELAM and VCAM can be used to assist in determining cell population purity...
  20. Corsi E. Vascular inflammation. CMAJ. 2007;176:1860 pubmed
  21. Bierings R, van den Biggelaar M, Kragt A, Mertens K, Voorberg J, Van Mourik J. Efficiency of von Willebrand factor-mediated targeting of interleukin-8 into Weibel-Palade bodies. J Thromb Haemost. 2007;5:2512-9 pubmed
    ..After de novo synthesis in endothelial cells, the chemokine interleukin-8 (IL-8) is targeted to endothelial cell-specific storage vesicles, the Weibel-Palade bodies (WPBs), where it colocalizes with von Willebrand factor (VWF)...
  22. Valentijn K, Valentijn J, Jansen K, Koster A. A new look at Weibel-Palade body structure in endothelial cells using electron tomography. J Struct Biol. 2008;161:447-58 pubmed
    ..Although the mechanism of assembly of vWF multimers into tubules is still unknown, the curled arrangement of the tubules within WPBs suggests a high degree of folding of the protein inside the organelle...
  23. Romani de Wit T, Rondaij M, Van Mourik J. [Weibel-Palade bodies: unique secretory organelles within endothelial cells]. Ned Tijdschr Geneeskd. 2004;148:1572-7 pubmed
    ..Weibel-Palade bodies may also move to the nucleus of the cell, thus escaping secretion. This phenomenon may play a part in controlling stimulus-induced exocytosis...
  24. Chauhan A, Kisucka J, Brill A, Walsh M, Scheiflinger F, Wagner D. ADAMTS13: a new link between thrombosis and inflammation. J Exp Med. 2008;205:2065-74 pubmed publisher
    ..Our findings reveal an important role for ADAMTS13 in preventing excessive spontaneous Weibel-Palade body secretion, and in the regulation of leukocyte adhesion and extravasation during inflammation...
  25. Haberichter S, Merricks E, Fahs S, Christopherson P, Nichols T, Montgomery R. Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells. Blood. 2005;105:145-52 pubmed
    ..These VWF-null endothelial cells provide a unique opportunity to examine the biogenesis of Weibel-Palade bodies in endothelium from a canine model of type 3 VWD...
  26. Chalajour F, Treede H, Ebrahimnejad A, Lauke H, Reichenspurner H, Ergun S. Angiogenic activation of valvular endothelial cells in aortic valve stenosis. Exp Cell Res. 2004;298:455-64 pubmed
    ..These data provide new insights into the mechanisms of valvular disorders and open new perspectives for prevention and early treatment of calcified aortic stenosis...
  27. Bhatia R, Matsushita K, Yamakuchi M, Morrell C, Cao W, Lowenstein C. Ceramide triggers Weibel-Palade body exocytosis. Circ Res. 2004;95:319-24 pubmed
    ..These data suggest a novel mechanism by which ceramide induces vascular inflammation and thrombosis...
  28. Berriman J, Li S, Hewlett L, Wasilewski S, Kiskin F, Carter T, et al. Structural organization of Weibel-Palade bodies revealed by cryo-EM of vitrified endothelial cells. Proc Natl Acad Sci U S A. 2009;106:17407-12 pubmed publisher
    ..We build a 3D model of a WPB in which individual VWF helices can bend, but in which the paracrystalline packing of VWF tubules, closely wrapped by the WPB membrane, is associated with the rod-like morphology of the granules...
  29. Sollner T, Sequeira S. S-nitrosylation of NSF controls membrane trafficking. Cell. 2003;115:127-9 pubmed
  30. Inomata M, Into T, Nakashima M, Noguchi T, Matsushita K. IL-4 alters expression patterns of storage components of vascular endothelial cell-specific granules through STAT6- and SOCS-1-dependent mechanisms. Mol Immunol. 2009;46:2080-9 pubmed publisher
  31. Wang M, Su Y, Sun H, Wang T, Yan G, Ran X, et al. Induced endothelial differentiation of cells from a murine embryonic mesenchymal cell line C3H/10T1/2 by angiogenic factors in vitro. Differentiation. 2010;79:21-30 pubmed publisher
    ..This in vitro model is useful for investigating the molecular events in endothelial differentiation of mesenchymal stem cells...
  32. de Leeuw H, Fernandez Borja M, Reits E, Romani de Wit T, Wijers Koster P, Hordijk P, et al. Small GTP-binding protein Ral modulates regulated exocytosis of von Willebrand factor by endothelial cells. Arterioscler Thromb Vasc Biol. 2001;21:899-904 pubmed
    ..These results indicate that Ral is involved in regulated exocytosis of Weibel-Palade bodies by endothelial cells...
  33. van Mourik J, Romani de Wit T, Voorberg J. Biogenesis and exocytosis of Weibel-Palade bodies. Histochem Cell Biol. 2002;117:113-22 pubmed
  34. Zhou C, Chen H, Lu F, Sellak H, Daigle J, Alexeyev M, et al. Cav3.1 (alpha1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2007;292:L833-44 pubmed
    ..1 T-type Ca2+ channels in PMVECs provides a unique cytosolic Ca2+ source important for Gq-linked agonist-induced VWF release...
  35. Matsushita K, Morrell C, Cambien B, Yang S, Yamakuchi M, Bao C, et al. Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell. 2003;115:139-50 pubmed
    ..NO may regulate exocytosis in a variety of physiological processes, including vascular inflammation, neurotransmission, thrombosis, and cytotoxic T lymphocyte cell killing...
  36. Rondaij M, Bierings R, Kragt A, van Mourik J, Voorberg J. Dynamics and plasticity of Weibel-Palade bodies in endothelial cells. Arterioscler Thromb Vasc Biol. 2006;26:1002-7 pubmed
    ..This is most likely needed to allow for controlled delivery of bioactive components into the circulation on vascular perturbation...
  37. Ryska A, Ludvikova M, Szepe P, Boor A. Epithelioid haemangiosarcoma of the thyroid gland. Report of six cases from a non-Alpine region. Histopathology. 2004;44:40-6 pubmed
    ..To report a series of six cases of thyroid haemangiosarcoma (HAS) from a non-Alpine region...
  38. Øynebråten I, Bakke O, Brandtzaeg P, Johansen F, Haraldsen G. Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood. 2004;104:314-20 pubmed
    ..In conclusion, we propose that rapid release of chemokines is restricted to those primarily recruiting leukocytes of the innate immune system, and that their storage in ECs is not restricted to the WPB compartment...
  39. Takayama A, Nakashima O, Kobayashi K, Kojiro M. Splenic lymphangioma with papillary endothelial proliferation: a case report and review of the literature. Pathol Int. 2003;53:483-8 pubmed
    ..Splenic lymphangioma with papillary endothelial proliferation is uncommon, and there have been only four cases reported...
  40. Yang S, Yan J, Deshpande S, Irani K, Lowenstein C. Rac1 regulates the release of Weibel-Palade Bodies in human aortic endothelial cells. Chin Med J (Engl). 2004;117:1143-50 pubmed
    ..But the signal transduction pathway leading to WPB release is not yet defined. We hypothesized that small G-protein rac1 and reactive oxygen species (ROS) mediate the ligand induced release of Weibel-Palade Bodies...
  41. Bae J, Rezaie A. Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies. J Thromb Haemost. 2010;8:1107-15 pubmed publisher
    ..The antagonist of this pathway, Ang2, is stored in Weibel-Palade bodies within endothelial cells...
  42. Hol J, Küchler A, Johansen F, Dalhus B, Haraldsen G, Oynebråten I. Molecular requirements for sorting of the chemokine interleukin-8/CXCL8 to endothelial Weibel-Palade bodies. J Biol Chem. 2009;284:23532-9 pubmed publisher
    ..We conclude that loop 2 of IL-8 constitutes a critical signal for sorting to WPB and propose a general role for this loop in the sorting of chemokines to compartments of regulated secretion...
  43. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung M, et al. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009;20:1623-32 pubmed publisher
    ..In patients with progressive hypertensive renal disease, a CHGA haplotype predicted rate of GFR decline. In conclusion, these data suggest that CHGA acts through the glomerular endothelium to regulate renal function...
  44. Royo T, Martinez Gonzalez J, Vilahur G, Badimon L. Differential intracellular trafficking of von Willebrand factor (vWF) and vWF propeptide in porcine endothelial cells lacking Weibel-Palade bodies and in human endothelial cells. Atherosclerosis. 2003;167:55-63 pubmed
    ..Our results confirm that PAEC express very low levels of vWF mRNA and indicate that in these cells, that do not have WPB, vWF and vWFpp have divergent intracellular trafficking pathways...
  45. Matsushita K, Yamakuchi M, Morrell C, Ozaki M, O ROURKE B, Irani K, et al. Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis. Blood. 2005;105:207-14 pubmed
    ..Thus, VEGF plays a dual role in regulating endothelial exocytosis, triggering pathways that both promote and inhibit endothelial exocytosis. Regulation of endothelial exocytosis may explain part of the proinflammatory effects of VEGF...
  46. Babich V, Knipe L, Hewlett L, Meli A, Dempster J, Hannah M, et al. Differential effect of extracellular acidosis on the release and dispersal of soluble and membrane proteins secreted from the Weibel-Palade body. J Biol Chem. 2009;284:12459-68 pubmed publisher
    ..Together, these data suggest that WPB exocytosis during extracellular acidosis may favor the control of inflammatory processes...
  47. Nico B, Crivellato E, Ribatti D. The importance of electron microscopy in the study of capillary endothelial cells: an historical review. Endothelium. 2007;14:257-64 pubmed
    ..This review article summarizes the literature data concerning the important role played by the electron microscope in the study and characterization of capillary endothelial cells...
  48. Orenstein J. Ultrastructure of Kaposi sarcoma. Ultrastruct Pathol. 2008;32:211-20 pubmed publisher
    ..The final stages of RBC disintegration were hemosiderin and ferritin. Most significantly, this study disclosed that KS is actually composed of a single type of randomly oriented spindle cell forming vessels of varying size and integrity...
  49. Tu J, Stoodley M, Morgan M, Storer K. Ultrastructural characteristics of hemorrhagic, nonhemorrhagic, and recurrent cavernous malformations. J Neurosurg. 2005;103:903-9 pubmed
    ..Ultrastructural characteristics of hemorrhagic, nonhemorrhagic, primary, and recurrent central nervous system cavernous malformations (CMs) were examined in an attempt to clarify their pathological mechanisms...
  50. Nakayama T, Sato W, Yoshimura A, Zhang L, Kosugi T, Campbell Thompson M, et al. Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney. Am J Pathol. 2010;176:2198-208 pubmed publisher
    ..A lack of nitric oxide likely contributed to the release of vWF, leading to thrombus formation in this model...
  51. Jeong Y, Chaupin D, Matsushita K, Yamakuchi M, Cameron S, Morrell C, et al. Aldosterone activates endothelial exocytosis. Proc Natl Acad Sci U S A. 2009;106:3782-7 pubmed publisher
    ..Aldosterone antagonism may decrease vascular inflammation and cardiac fibrosis in part by blocking endothelial exocytosis...
  52. Doi Y, Kudo H, Nishino T, Nagata T, Fujimoto S. The enhancement of preproendothelin-1 synthesis and the acceleration of endothelin-1 processing in the acute hypoxic rat aorta. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S207-10 pubmed
    ..These findings indicate the enhancement of preproendothelin-1 synthesis in the rat aortic endothelial cells and the acceleration of ET-1 processing in Weibel-Palade bodies of such cells in an acute hypoxic condition...
  53. Bertuglia S, Ichimura H, Fossati G, Parthasarathi K, Leoni F, Modena D, et al. ITF1697, a stable Lys-Pro-containing peptide, inhibits weibel-palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med. 2007;13:615-24 pubmed
  54. Schmugge M, Rand M, Freedman J. Platelets and von Willebrand factor. Transfus Apher Sci. 2003;28:269-77 pubmed
    ..Finally, the review discusses the role of locally released VWF from platelet alpha-granules and from Weibel-Palade bodies for platelet activation in neonates and adults...
  55. Miyagami M, Katayama Y. Angiogenesis of glioma: evaluation of ultrastructural characteristics of microvessels and tubular bodies (Weibel-Palade) in endothelial cells and immunohistochemical findings with VEGF and p53 protein. Med Mol Morphol. 2005;38:36-42 pubmed
    ..However, the MIB-1 indices did not increase in correlation with increase in the extent of immunoreactivity for VEGF...
  56. Goerge T, Niemeyer A, Rogge P, Ossig R, Oberleithner H, Schneider S. Secretion pores in human endothelial cells during acute hypoxia. J Membr Biol. 2002;187:203-11 pubmed
    ..However, at nanometer scale, hypoxia instantaneously switches the smooth luminal plasma membrane to a rough activated cell surface, covered with secretion pores that release vWF to the luminal cell surface...
  57. Nishiyama T, Mishima K, Ide F, Yamada K, Obara K, Sato A, et al. Functional analysis of an established mouse vascular endothelial cell line. J Vasc Res. 2007;44:138-48 pubmed
    ..The purpose of our study is to develop a new immortalized aortic vascular endothelial cell (EC) line that retains endothelial characteristics and can facilitate the study of ECs...
  58. Lowenstein C, Morrell C, Yamakuchi M. Regulation of Weibel-Palade body exocytosis. Trends Cardiovasc Med. 2005;15:302-8 pubmed
    ..This review examines the regulation of WPB exocytosis-the exocytic machinery, activators, and inhibitors of exocytosis-and speculates about the development of novel anti-exocytic drugs...
  59. Neumüller J, Neumüller Guber S, Lipovac M, Mosgoeller W, Vetterlein M, Pavelka M, et al. Immunological and ultrastructural characterization of endothelial cell cultures differentiated from human cord blood derived endothelial progenitor cells. Histochem Cell Biol. 2006;126:649-64 pubmed
    ..In this respect, these investigations provide new insights into the in vitro differentiation which could have some in vivo correlation...
  60. Doi Y, Kudo H, Yamamoto O, Hamasaki K, Yoshizuka M, Fujimoto S. Enhancement of immunoreactivity for endothelin-1 and endothelin-converting enzyme-1 in the cadmium-treated rat thoracic aorta. Virchows Arch. 2002;441:179-86 pubmed
  61. Klarenbach S, Chipiuk A, Nelson R, Hollenberg M, Murray A. Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases. Circ Res. 2003;92:272-8 pubmed
    ..In contrast, the differential effect of PAR1 versus PAR2 activation to increase monolayer permeability correlates with weak RhoA activation by the PAR2 agonist...
  62. Zannettino A, Holding C, Diamond P, Atkins G, Kostakis P, Farrugia A, et al. Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. J Cell Physiol. 2005;204:714-23 pubmed