menispermaceae

Summary

Summary: A plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. Members are mostly vines and shrubs and they contain isoquinoline alkaloids, some of which have been used as arrow poisons.

Top Publications

  1. de Lira G, de Andrade L, Florêncio K, da Silva M, Barbosa Filho J, Leitão da Cunha E. Roraimine: a bisbenzylisoquinoline alkaloid from Cissampelos sympodialis roots. Fitoterapia. 2002;73:356-8 pubmed
    ..The roots of Cissampelos sympodialis yielded Roraimine (1), a novel bisbenzylisoquinoline alkaloid and liriodenine (2), a known oxoaporphine alkaloid...
  2. Cheng G, Jian X, Tao T. [Determination of tetrandine content in tetrandine microsphere]. Zhong Yao Cai. 2002;25:739-40 pubmed
    ..To determine the contents of tetrandine in tetrandine microsphere for the quality control of the preparation...
  3. Otshudi A, Apers S, Pieters L, Claeys M, Pannecouque C, De Clercq E, et al. Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum. J Ethnopharmacol. 2005;102:89-94 pubmed
    Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities...
  4. Wattanathorn J, Uabundit N, Itarat W, Mucimapura S, Laopatarakasem P, Sripanidkulchai B. Neurotoxicity of Coscinium fenestratum stem, a medicinal plant used in traditional medicine. Food Chem Toxicol. 2006;44:1327-33 pubmed
    ..It is concluded that the plant possesses neurotoxicity and is able to induce neurobehavioral changes in rats. Therefore, the application of this plant as either drug or supplementary food should be reconsidered...
  5. Moody J, Robert V, Connolly J, Houghton P. Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae). J Ethnopharmacol. 2006;104:87-91 pubmed
    ..5% inhibition at 100 mg kg(-1)). The results provide some justification for the folkloric uses of Sphenocentrum jollyanum in the treatment of inflammatory-based diseases across the West African sub-region...
  6. Jiang Y, Jiao Y, Liu Y, Zhang M, Wang Z, Li Y, et al. Sinomenine Hydrochloride Inhibits the Metastasis of Human Glioblastoma Cells by Suppressing the Expression of Matrix Metalloproteinase-2/-9 and Reversing the Endogenous and Exogenous Epithelial-Mesenchymal Transition. Int J Mol Sci. 2018;19: pubmed publisher
    ..et Wils. (Fam. Menispermaceae), initiates the autophagy-mediated death of human glioblastoma cells by generating reactive oxygen species ..
  7. Bafna P, Balaraman R. Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation. Phytomedicine. 2005;12:264-70 pubmed
    ..Thus it can be concluded that Pepticare possesses anti-ulcer activity, which can be attributed to its anti-oxidant mechanism of action. ..
  8. Lee J, Kim K, Kim J, Choi S, Kim S, Ryu S. Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum. Arch Pharm Res. 2016;39:713-20 pubmed publisher
    A phytochemical investigation for the rhizome extract from Sinomenium acutum (Menispermaceae) resulted in the isolation of several active principles responsible for the anti-osteoclastogenic property of the extract, together with related ..
  9. Kumari S, Mittal A, Dabur R. Moderate alcohol consumption in chronic form enhances the synthesis of cholesterol and C-21 steroid hormones, while treatment with Tinospora cordifolia modulate these events in men. Steroids. 2016;114:68-77 pubmed publisher
    ..Furthermore, effects of standardized water extract of Tinospora cordifolia (Willd) Mier. (Menispermaceae) (TCJ), a well reported anti-alcoholic herbal drug, on urinary steroids was studied...
  10. Scotti L, Mendonça F, Da Silva M, Scotti M. Enzymatic Targets in Trypanosoma brucei. Curr Protein Pept Sci. 2016;17:243-59 pubmed
    ..associated with structure-based-virtual screening (docking), to a small dataset of 225 alkaloids from the Menispermaceae family (in-house data bank)...

Detail Information

Publications95

  1. de Lira G, de Andrade L, Florêncio K, da Silva M, Barbosa Filho J, Leitão da Cunha E. Roraimine: a bisbenzylisoquinoline alkaloid from Cissampelos sympodialis roots. Fitoterapia. 2002;73:356-8 pubmed
    ..The roots of Cissampelos sympodialis yielded Roraimine (1), a novel bisbenzylisoquinoline alkaloid and liriodenine (2), a known oxoaporphine alkaloid...
  2. Cheng G, Jian X, Tao T. [Determination of tetrandine content in tetrandine microsphere]. Zhong Yao Cai. 2002;25:739-40 pubmed
    ..To determine the contents of tetrandine in tetrandine microsphere for the quality control of the preparation...
  3. Otshudi A, Apers S, Pieters L, Claeys M, Pannecouque C, De Clercq E, et al. Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum. J Ethnopharmacol. 2005;102:89-94 pubmed
    Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities...
  4. Wattanathorn J, Uabundit N, Itarat W, Mucimapura S, Laopatarakasem P, Sripanidkulchai B. Neurotoxicity of Coscinium fenestratum stem, a medicinal plant used in traditional medicine. Food Chem Toxicol. 2006;44:1327-33 pubmed
    ..It is concluded that the plant possesses neurotoxicity and is able to induce neurobehavioral changes in rats. Therefore, the application of this plant as either drug or supplementary food should be reconsidered...
  5. Moody J, Robert V, Connolly J, Houghton P. Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae). J Ethnopharmacol. 2006;104:87-91 pubmed
    ..5% inhibition at 100 mg kg(-1)). The results provide some justification for the folkloric uses of Sphenocentrum jollyanum in the treatment of inflammatory-based diseases across the West African sub-region...
  6. Jiang Y, Jiao Y, Liu Y, Zhang M, Wang Z, Li Y, et al. Sinomenine Hydrochloride Inhibits the Metastasis of Human Glioblastoma Cells by Suppressing the Expression of Matrix Metalloproteinase-2/-9 and Reversing the Endogenous and Exogenous Epithelial-Mesenchymal Transition. Int J Mol Sci. 2018;19: pubmed publisher
    ..et Wils. (Fam. Menispermaceae), initiates the autophagy-mediated death of human glioblastoma cells by generating reactive oxygen species ..
  7. Bafna P, Balaraman R. Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation. Phytomedicine. 2005;12:264-70 pubmed
    ..Thus it can be concluded that Pepticare possesses anti-ulcer activity, which can be attributed to its anti-oxidant mechanism of action. ..
  8. Lee J, Kim K, Kim J, Choi S, Kim S, Ryu S. Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum. Arch Pharm Res. 2016;39:713-20 pubmed publisher
    A phytochemical investigation for the rhizome extract from Sinomenium acutum (Menispermaceae) resulted in the isolation of several active principles responsible for the anti-osteoclastogenic property of the extract, together with related ..
  9. Kumari S, Mittal A, Dabur R. Moderate alcohol consumption in chronic form enhances the synthesis of cholesterol and C-21 steroid hormones, while treatment with Tinospora cordifolia modulate these events in men. Steroids. 2016;114:68-77 pubmed publisher
    ..Furthermore, effects of standardized water extract of Tinospora cordifolia (Willd) Mier. (Menispermaceae) (TCJ), a well reported anti-alcoholic herbal drug, on urinary steroids was studied...
  10. Scotti L, Mendonça F, Da Silva M, Scotti M. Enzymatic Targets in Trypanosoma brucei. Curr Protein Pept Sci. 2016;17:243-59 pubmed
    ..associated with structure-based-virtual screening (docking), to a small dataset of 225 alkaloids from the Menispermaceae family (in-house data bank)...
  11. Sun Y, Moore M, Zhang S, Soltis P, Soltis D, Zhao T, et al. Phylogenomic and structural analyses of 18 complete plastomes across nearly all families of early-diverging eudicots, including an angiosperm-wide analysis of IR gene content evolution. Mol Phylogenet Evol. 2016;96:93-101 pubmed publisher
    ..Berberidaceae), Euptelea pleiosperma (Eupteleaceae), Akebia trifoliata (Lardizabalaceae), Stephania japonica (Menispermaceae) and Papaver somniferum (Papaveraceae), and compared them to previously published plastomes of the early-..
  12. Vijayan D, Cheethaparambil A, Pillai G, Balachandran I. Molecular authentication of Cissampelos pareira L. var. hirsuta (Buch.-Ham. ex DC.) Forman, the genuine source plant of ayurvedic raw drug 'Patha', and its other source plants by ISSR markers. 3 Biotech. 2014;4:559-562 pubmed publisher
    Cissampelos pareira L. var. hirsuta (Buch.-Ham. ex DC.) Forman belongs to family Menispermaceae. The roots of this taxon are used in the treatment of various diseases like stomach pain, fever, skin disease, etc...
  13. Haque M, Jantan I, Abbas Bukhari S. Tinospora species: An overview of their modulating effects on the immune system. J Ethnopharmacol. 2017;207:67-85 pubmed publisher
    ..Amongst the medicinal plants, Tinospora species (family; Menispermaceae) have been one of the widely investigated plants for their modulating effects on the immune system due to ..
  14. Rao G, Zhang S, Wang H, Li Z, Gao S, Xu G. Antifungal alkaloids from the fresh rattan stem of Fibraurea recisa Pierre. J Ethnopharmacol. 2009;123:1-5 pubmed publisher
    ..Bioassay tests revealed that the water-soluble berberines are the most important antifungal substances. The study provides preliminary scientific validation for the traditional medicinal use of this ethno-remedy. ..
  15. Yang S, Chen P. Endocarps of menispermaceous plants in Taiwan. Bot Stud. 2016;57:14 pubmed publisher
    The fruits of the family Menispermaceae are drupes, and because the drupe endocarps are morphologically diverse, they are generally used to classify members of this family...
  16. Jayasinghe U, Balasooriya B, Hara N, Fujimoto Y. Steroidal and triterpenoidal saponins from the fruits of Diploclisia glaucescens. Nat Prod Res. 2005;19:245-51 pubmed
    ..The latter saponin was found to be a new natural product while the other two are reported for the first time from the family Menispermaceae.
  17. Wang W, Ortiz R, Jacques F, Chung S, Liu Y, Xiang X, et al. New insights into the phylogeny of Burasaieae (Menispermaceae) with the recognition of a new genus and emphasis on the southern Taiwanese and mainland Chinese disjunction. Mol Phylogenet Evol. 2017;109:11-20 pubmed publisher
    ..from six plastid and nuclear sequences were used to reconstruct phylogenetic relationships within Burasaieae (Menispermaceae), which mainly inhabits tropical rainforests...
  18. Iloh A, Schmidt M, Muellner Riehl A, Ogundipe O, Paule J. Pleistocene refugia and genetic diversity patterns in West Africa: Insights from the liana Chasmanthera dependens (Menispermaceae). PLoS ONE. 2017;12:e0170511 pubmed publisher
    ..in the area of the DG and the borders of LG and UG of the widespread liana species, Chasmanthera dependens (Menispermaceae) by amplified fragment length polymorphism (AFLP), a chloroplast DNA sequence marker, and modelled the ..
  19. Singh B, Sharma P, Kumar A, Chadha P, Kaur R, Kaur A. Antioxidant and in vivo genoprotective effects of phenolic compounds identified from an endophytic Cladosporium velox and their relationship with its host plant Tinospora cordifolia. J Ethnopharmacol. 2016;194:450-456 pubmed publisher
    Tinospora cordifolia (Willd. Hook. f. & Thomson; family: Menispermaceae), has a long history of use in various traditional medicinal systems including "Ayurveda"...
  20. Adams N, Collinson M, Smith S, Bamford M, Forest F, Malakasi P, et al. X-rays and virtual taphonomy resolve the first Cissus (Vitaceae) macrofossils from Africa as early-diverging members of the genus. Am J Bot. 2016;103:1657-77 pubmed publisher
    ..Cissus (Vitaceae) have been recognized from the Miocene of Kenya, though some were previously assigned to the Menispermaceae. We undertook a comparative survey of extant African Cissus seeds to identify the fossils and consider their ..
  21. Ricciardi Verrastro B, Maria Torres A, Ricciardi G, Teibler P, Maruñak S, Barnaba C, et al. The effects of Cissampelos pareira extract on envenomation induced by Bothropsdiporus snake venom. J Ethnopharmacol. 2018;212:36-42 pubmed publisher
    ..In the northeast of the country (Corrientes Provinces), Cissampelos pareira L. (Menispermaceae) is commonly used against the venom of B...
  22. Xue W, Carey J, Linse S. Multi-method global analysis of thermodynamics and kinetics in reconstitution of monellin. Proteins. 2004;57:586-95 pubmed
    ..8 J mol(-1) K(-1) (-TDeltaS degrees = -23.8 kJ/mol). The association of monellin is therefore a bimolecular intra-protein association whose energetics are slightly dominated by entropic factors. ..
  23. Su B, Jones W, Cuendet M, Kardono L, Ismail R, Riswan S, et al. Constituents of the stems of Macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1 and -2. Phytochemistry. 2004;65:2861-6 pubmed
    ..The COX-2 inhibitory activity of the EtOAc extract was also traced to the presence of several common fatty acids by LC-MS. ..
  24. Silva L, Alves A, Cavalcante Silva L, Braga R, de Almeida R, Barbosa Filho J, et al. Milonine, a Morphinandienone Alkaloid, Has Anti-Inflammatory and Analgesic Effects by Inhibiting TNF-? and IL-1? Production. Inflammation. 2017;40:2074-2085 pubmed publisher
    Milonine is a morphinandienone alkaloid from Cissampelos sympodialis Eichl (Menispermaceae), a plant used in Brazil to treat inflammatory disorders...
  25. Jayasinghe L, Jayasooriya C, Oyama K, Fujimoto Y. 3-Deoxy-1beta,20-dihydroxyecdysone from the leaves of Diploclisia glaucescens. Steroids. 2002;67:555-8 pubmed
    Chemical investigation of methanol extract of the leaves of Diploclisia glaucescens of the family Menispermaceae furnished a new ecdysteroid, 3-deoxy-1beta,20-dihydroxyecdysone...
  26. De la Fuente J, Jullian C, Saitz C, Sobarzo Sanchez E, Neira V, Gonzalez C, et al. Photoreduction of oxoisoaporphines. Another example of a formal hydride-transfer mechanism. Photochem Photobiol Sci. 2004;3:194-9 pubmed
    ..We present spectrophotometric, NMR and UV-vis data for the metastable photoproducts. The spectrophotometric results and PM3 and ZINDO/S calculations support the proposed mechanism for the photoreduction of the oxoisoaporphines. ..
  27. Tiam E, Ngono Bikobo D, Abouem à Zintchem A, Mbabi Nyemeck N, Moni Ndedi E, Betote Diboué P, et al. Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis. Nat Prod Res. 2017;:1-9 pubmed publisher
    ..Compounds 1, 2, 8 and 9 displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with minimum inhibitory concentrations MICs ranging from 3.90 to 62.5 ?g/mL...
  28. Xue W, Szczepankiewicz O, Bauer M, Thulin E, Linse S. Intra- versus intermolecular interactions in monellin: contribution of surface charges to protein assembly. J Mol Biol. 2006;358:1244-55 pubmed
    ..These results indicate that Coulombic interactions are likely to be of main importance for the association of protein assembly, relevant for functions of proteins. ..
  29. Akah P, Nwafor S, Okoli C, Egbogha C. Evaluation of the sedative properties of the ethanolic root extract of Cissampelos mucronata. Boll Chim Farm. 2002;141:243-6 pubmed
    ..The mechanism of action is not precisely known but may probably be attributed to central nervous system depressant action. ..
  30. Alves A, Vieira G, Gadelha F, Cavalcante Silva L, Martins M, Barbosa Filho J, et al. Milonine, an Alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae) Inhibits Histamine Release of Activated Mast Cells. Inflammation. 2017;40:2118-2128 pubmed publisher
    Milonine is an alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae), a plant used in the northeast of Brazil to treat allergies such as asthma, rhinitis, and other conditions...
  31. Blanchfield J, Sands D, Kennard C, Byriel K, Kitching W. Characterisation of alkaloids from some Australian Stephania (Menispermaceae) species. Phytochemistry. 2003;63:711-20 pubmed
    ..The alkaloids from the forest vines Stephania bancroftii F.M. Bailey and S. aculeata F.M. Bailey (Menispermaceae) have been isolated and characterised...
  32. Sureram S, Senadeera S, Hongmanee P, Mahidol C, Ruchirawat S, Kittakoop P. Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2012;22:2902-5 pubmed publisher
    ..7 to 6.2 ?g/ml, but they exhibited the MIC value at 3.1 ?g/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. ..
  33. Herrera F, Manchester S, Hoot S, Wefferling K, Carvalho M, Jaramillo C. Phytogeographic implications of fossil endocarps of Menispermaceae from the Paleocene of Colombia. Am J Bot. 2011;98:2004-17 pubmed publisher
    Fossil leaves of Menispermaceae were previously described from the Paleocene of Colombia...
  34. Swaffar D, Holley C, Fitch R, Elkin K, Zhang C, Sturgill J, et al. Phytochemical investigation and in vitro cytotoxic evaluation of alkaloids from Abuta rufescens. Planta Med. 2012;78:230-2 pubmed publisher
    ..The azafluoranthene alkaloid imeluteine exhibited lesser cytotoxicity, as did one of the oxoaporphine alkaloids. ..
  35. Olorunnisola O, Fadahunsi O, Adegbola P. A Review on Ethno-Medicinal and Pharmacological Activities of Sphenocentrum jollyanum Pierre. Medicines (Basel). 2017;4: pubmed publisher
    i>Sphenocentrum jollyanum Pierre is a member of a diverse family of plants known as Menispermaceae. They are famous for a plethora of important biological functions. S...
  36. Yan M, Cheng P, Jiang Z, Ma Y, Zhang X, Zhang F, et al. Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus. J Nat Prod. 2008;71:760-3 pubmed publisher
    ..14 mM. Norruffscine (5) and (-)-8-oxotetrahydropalmatine (6) exhibited inhibitory activity against human immunodeficiency virus (HIV-1) with EC(50) values of 10.9 and 14.1 microM in C8166 cells (SI = 45.7 and 18.8), respectively. ..
  37. Wongcome T, Panthong A, Jesadanont S, Kanjanapothi D, Taesotikul T, Lertprasertsuke N. Hypotensive effect and toxicology of the extract from Coscinium fenestratum (Gaertn.) Colebr. J Ethnopharmacol. 2007;111:468-75 pubmed
  38. Yu L, Hu W, Ding G, Li R, Wei J, Zou Z, et al. Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung. J Nat Prod. 2011;74:1009-14 pubmed publisher
    ..Compounds 1-4 exhibited strong inhibitory effects not only on the mushroom tyrosinase activity in vitro but also on melanogenesis in cells...
  39. Gbolade A, Adeyemi A. Investigation of in vitro anthelmintic activities of Pycnanthus angolensis and Sphenocentrum jollyanum. Fitoterapia. 2008;79:220-2 pubmed publisher
    ..001), while fruit ethanolic extract of S. jollyanum was also more potent than the seed extract. When compared with other worms, S. jollyanum fruit extract showed the greatest activity on wireworms when tested at 80 mg/ml...
  40. De Wet H, van Heerden F, van Wyk B. Alkaloidal variation in cissampelos capensis (Menispermaceae). Molecules. 2011;16:3001-9 pubmed publisher
    ..or "dawidjieswortel", is the most important and best known medicinal plant of the family Menispermaceae used by the Khoisan and other rural people in the western region of South Africa...
  41. Su C, Chen Y, Liou M, Tsai H, Chang W, Wu T. Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria. Bioorg Med Chem. 2008;16:9603-9 pubmed publisher
    ..The inhibitory effects of these compounds are dose-dependent (1-4 microg/ml)...
  42. Sugimoto Y, Matsui M, Babiker H. Conversion of dechlorodauricumine into chlorinated alkaloids in Menispermum dauricum root culture. Phytochemistry. 2007;68:493-8 pubmed
    ..These findings suggest that dechlorodauricumine is the principal precursor of the chlorinated alkaloids produced by M. dauricum roots...
  43. Ling J, Xie B, Wang Y, Zhou L. [Dynamic determination of sinomenine in skin by microdialysis]. Zhong Yao Cai. 2008;31:1062-5 pubmed
    ..To explore the feasibility and advantages of using microdialysis as sampling method for dynamic determination of sinomenine in topical skin...
  44. Wang Y, Zhou L, Ling J. [Effect of penetration enhancers on the transdermal penetration of sinomenine liposome patch]. Zhong Yao Cai. 2005;28:567-70 pubmed
    ..To study the effect of penetration enhancers on the transdermal penetration of sinomenine liposome patch...
  45. Johansen K, Ebild S, Christensen S, Godejohann M, Jaroszewski J. Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: new strategies going beyond the standard. J Chromatogr A. 2012;1270:171-7 pubmed publisher
    ..In contrast, GP resin proved only viable for all the H. selago alkaloids whereas trapping and elution of bisbenzylisoquinoline alkaloids were dubious...
  46. Chomnawang M, Trinapakul C, Gritsanapan W. In vitro antigonococcal activity of Coscinium fenestratum stem extract. J Ethnopharmacol. 2009;122:445-9 pubmed publisher
    ..It is still one of the major health problems worldwide in both men and women. Many medicinal plants have been recorded in Thai folk medicine for relieving STD but there is no scientific report of these plants for antigonococcal activity...
  47. Jayasinghe L, Mallika Kumarihamy B, Suranga Arundathie B, Dissanayake L, Hara N, Fujimoto Y. A new ecdysteroid, 2-deoxy-5beta,20-dihydroxyecdysone from the fruits of Diploclisia glaucescens. Steroids. 2003;68:447-50 pubmed
    Chemical investigation of ethyl acetate extract of the fruits of Diploclisia glaucescens of the family Menispermaceae furnished a new ecdysteroid 2-deoxy-5beta,20-dihydroxyecdysone, together with 20-hydroxyecdysone, 3-deoxy-1beta,20-..
  48. Wang E, Ma Y, Zhang X, Jiang Z, Chen J. [Five alkaloids from vine stems of Diploclisia affinis]. Zhongguo Zhong Yao Za Zhi. 2008;33:2503-5 pubmed
    ..To study alkaloid constituents of Diploclisia affinis...
  49. Carraz M, Jossang A, Rasoanaivo P, Mazier D, Frappier F. Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage. Bioorg Med Chem. 2008;16:6186-92 pubmed publisher
    ..Structures were characterized by 2D NMR, MS, and CD spectral analysis. Compounds 1-3 were found to fully inhibit the rodent P. yoelii liver stage parasites in vitro...
  50. Murebwayire S, Ingkaninan K, Changwijit K, Frederich M, Duez P. Triclisia sacleuxii (Pierre) Diels (Menispermaceae), a potential source of acetylcholinesterase inhibitors. J Pharm Pharmacol. 2009;61:103-7 pubmed publisher
    ..To search for compounds possibly useful for the treatment of Alzheimer's disease...
  51. Guedes D, Barbosa Filho J, Lemos V, Cortes S. Mechanism of the vasodilator effect of 12-O-methylcurine in rat aortic rings. J Pharm Pharmacol. 2002;54:853-8 pubmed
    ..of 12-O-methylcurine (OMC), a bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum (Menispermaceae), and its respective mechanism of action were investigated in rat aorta...
  52. Chen Q, Zhang J, Zhang W, Chen Z. Analysis of active alkaloids in the Menispermaceae family by nonaqueous capillary electrophoresis-ion trap mass spectrometry. J Sep Sci. 2013;36:341-9 pubmed publisher
    ..67% and the mean recovery of the analytes were 95.36-99.24%. This method was successfully applied to determine TET, FAN, and SIN in real samples radix Stephaniae tetrandrae and rhizomes of Menispermum dauricum...
  53. Pérez Cruz F, Aguilera Venegas B, Lapier M, Sobarzo Sanchez E, Uriarte Villares E, Olea Azar C. Host-guest interaction between new nitrooxoisoaporphine and ?-cyclodextrins: synthesis, electrochemical, electron spin resonance and molecular modeling studies. Spectrochim Acta A Mol Biomol Spectrosc. 2013;102:226-34 pubmed publisher
    ..Finally, these results are further interpreted by means of molecular modeling studies. Thus, theoretical results are in complete agreement with the experimental data...
  54. Wang W, Ortiz R, Jacques F, Xiang X, Li H, Lin L, et al. Menispermaceae and the diversification of tropical rainforests near the Cretaceous-Paleogene boundary. New Phytol. 2012;195:470-8 pubmed publisher
    ..Here, we used the moonseed family (Menispermaceae), an important physiognomic and structural component of tropical rainforests on a worldwide basis, to obtain ..
  55. Deevanhxay P, Suzuki M, Maeshibu N, Li H, Tanaka K, Hirose S. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry. J Pharm Biomed Anal. 2009;50:413-25 pubmed publisher
    ..The method can be applied for the analysis of 8-oxoberberine and other alkaloids in Coptis japonica, Phellodendron amurense, and other herbal medicines...
  56. Tuntiwachwuttikul P, Taylor W. New rearranged clerodane diterpenes from Tinospora baenzigeri. Chem Pharm Bull (Tokyo). 2001;49:854-7 pubmed
    ..Baenzigeride B and baenzigeroside B are the first examples of a new class of rearranged clerodane diterpenes. The possible biogenesis of the compounds is discussed...
  57. Dias C, Barbosa Filho J, Lemos V, Cortes S. Mechanisms involved in the vasodilator effect of curine in rat resistance arteries. Planta Med. 2002;68:1049-51 pubmed
  58. Jayasinghe L, Hara N, Fujimoto Y. Bidesmosidic saponins from the fruits of Diploclisia glaucescens. Phytochemistry. 2003;62:563-7 pubmed
    Chemical investigation of methanol extract of the fruits of Diploclisia glaucescens (Menispermaceae) furnished two new bidesmosidic saponins 3-O-[beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl]phytolaccagenic acid 28-O-beta-D-..
  59. Cheng G, Luo J. [Study on the stability of tetrandrine microsphere]. Zhong Yao Cai. 2005;28:429-31 pubmed
    ..To study the stability of Tetrandrine Microsphere...
  60. Nair G, Narasimhan S, Shiburaj S, Abraham T. Antibacterial effects of Coscinium fenestratum. Fitoterapia. 2005;76:585-7 pubmed
    ..Antibacterial activity of Coscinium fenestratum is mainly due to the presence of berberine...
  61. Subeki -, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, et al. Antibabesial activity of protoberberine alkaloids and 20-hydroxyecdysone from Arcangelisia flava against Babesia gibsoni in culture. J Vet Med Sci. 2005;67:223-7 pubmed
    ..Compounds (1-4) showed significant inhibitions at concentrations from 100 to 1.0 microg/ml, while compound 5 at a concentration of 100 microg/ml, only...
  62. Yu B, Chen J, Zhou T, Cheng K, Qin G. Nitrotyrasacutuminine from Menispermum dauricum. Nat Prod Lett. 2002;16:155-9 pubmed
    ..Nitrotyrasacutuminine, an unusual nitrated morphine-type alkaloid was isolated from the roots of Menispermum dauricum. Its structure was determined by various 2D spectra and chemical methods...
  63. Jayasinghe U, Jayasooriya C, Fujimoto Y. Oleanane glycosides from the leaves of Diploclisia glaucescens. Fitoterapia. 2002;73:406-10 pubmed
  64. Ganapaty S, Dash G, Subburaju T, Suresh P. Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts. Fitoterapia. 2002;73:28-31 pubmed
    ..The aqueous extract of the Cocculus hirsutus aerial parts (100 and 200 mg/kg, p.o.) showed significant diuretic activity and laxative effect in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg...
  65. Kikueta C, Kambu O, Mbenza A, Mavinga S, Mbamu B, Cos P, et al. In vitro and in vivo antimalarial activity and cytotoxicity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii. J Ethnopharmacol. 2013;149:438-42 pubmed publisher
    ..antiplasmodial activity and cytotoxicity, and the in vivo activity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii (De Wild) Staner (Menispermaceae), used in traditional medicine against malaria.
  66. Githinji E, Irungu L, Tonui W, Rukunga G, Mutai C, Muthaura C, et al. In vitro effects of Warburgia ugandensis, Psiadia punctulata and Chasmanthera dependens on Leishmania major promastigotes. Afr J Tradit Complement Altern Med. 2010;7:264-75 pubmed
    ..Canellaceae), Psiadia punctulata Vatke (Family: Compositae) and Chasmanthera dependens Hoschst (Family: Menispermaceae) were tested for activity on Leishmania major promastigotes (Strain IDU/KE/83 = NLB-144) and infected ..
  67. Venukumar M, Latha M. Antioxidant effect of Coscinium fenestratum in carbon tetrachloride treated rats. Indian J Physiol Pharmacol. 2002;46:223-8 pubmed
    ..The findings provide a rationale for further studies on isolation of active principles and its pharmacological evaluation...
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    ..To develop the optimal extraction procedure (i.e. maceration, percolation or Soxhlet extraction) and thin- layer chromatographic (TLC)-densitometric method for the determination of berberine content of Coscinium fenestratum...
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    ..albicans ATCC 3153 for compounds 2 and 3. The antibacterial and antifungal activities of the petroleum ether, chloroform, and methanol extracts of A. grandifolium stems were also evaluated...
  71. Murebwayire S, Frederich M, Hannaert V, Jonville M, Duez P. Antiplasmodial and antitrypanosomal activity of Triclisia sacleuxii (Pierre) Diels. Phytomedicine. 2008;15:728-33 pubmed publisher
    ..They also demonstrated antiplasmodial activity on Plasmodium falciparum 3D7, with IC(50) of 1.72, 0.93, 1.39 and 12.4 microM respectively and on the chloroquine-resistant W2 with IC(50) of 0.35, 1.10, 1.63 and 1.52 microM...
  72. Cometa M, Fortuna S, Palazzino G, Volpe M, Rengifo Salgado E, Nicoletti M, et al. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. Fitoterapia. 2012;83:476-80 pubmed publisher
    ..Interestingly, all tested alkaloids are more potent against BChE than against AChE. This selectivity of cholinesterase (ChE) inhibition could be important in order to speculate on their potential therapeutic relevance...
  73. del Rayo Camacho M, Phillipson J, Croft S, Rock P, Marshall S, Schiff P. In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against Leishmania donovani and Trypanosoma brucei brucei. Phytother Res. 2002;16:432-6 pubmed
    ..Thalisopidine showed the strongest activity (IC(50) = 1.14 microM) against Trypanosoma brucei brucei blood stream form trypomastigotes, but was less active than pentamidine...
  74. Lohombo Ekomba M, Okusa P, Penge O, Kabongo C, Choudhary M, Kasende O. Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa. J Ethnopharmacol. 2004;93:331-5 pubmed
    Albertisia villosa (Menispermaceae) is a subtropical medicinal plant that is widely used in traditional African medicines against various diseases...
  75. Shirwaikar A, Rajendran K, Punitha I. Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats. J Ethnopharmacol. 2005;97:369-74 pubmed
    The antidiabetic potential of the alcoholic stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus ..
  76. Shi Q, Yan S, Liang M, Yang Y, Wang Y, Zhang W. Simultaneous determination of eight components in Radix Tinosporae by high-performance liquid chromatography coupled with diode array detector and electrospray tandem mass spectrometry. J Pharm Biomed Anal. 2007;43:994-9 pubmed
    ..Tinosporae for quality control purpose. The results indicated that the proposed method could be readily utilized as a quality control method for traditional Chinese medicine (TCM)...
  77. Jayasinghe U, Hara N, Fujimoto Y. (2-Nitro ethyl)phenyl and cyanophenyl glycosides from the fruits of Diploclisia glaucescens. Nat Prod Res. 2007;21:260-4 pubmed
    ..of polar fractions of the methanol extract of the fruits of Diploclisia glaucescens of the family Menispermaceae furnished two new phenyl glycosides, 4-(2-nitroethyl)phenyl-beta-D-xylopyranosyl-(l approximately 6)-beta-D-..
  78. Gacche R, Dhole N. Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications. Food Chem Toxicol. 2011;49:1806-13 pubmed publisher
    ..Apocynaceae), Ocimum sanctum L. (Labiatae), Tinospora cordifolia Willd. (Menispermaceae), Aegle marmelos L. (Rutaceae), Ficus golmerata L. (Moraceae), Psoralea corlifolia L...
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    This work surveys endocarp morphology of Menispermaceae in the context of a well-supported molecular phylogeny...
  80. Zaridah M, Idid S, Omar A, Khozirah S. In vitro antifilarial effects of three plant species against adult worms of subperiodic Brugia malayi. J Ethnopharmacol. 2001;78:79-84 pubmed
    ..seeds (SX) and dried leaves (LX) of Xylocarpus granatum (Meliaceae), dried stems (ST) of Tinospora crispa (Menispermaceae) and dried leaves (LA) of Andrographis paniculata (Acanthaceae) were tested in vitro against adult worms of ..
  81. Jacob S, Mohammed H, Murali K, Kamarudeen M. Synthesis of silver nanorods using Coscinium fenestratum extracts and its cytotoxic activity against Hep-2 cell line. Colloids Surf B Biointerfaces. 2012;98:7-11 pubmed publisher
    ..5-68.0 nm. The MTT assay results revealed that silver nanorod exhibit significant cytotoxic effect on HEp-2 cells...
  82. Seal T, Mukherjee B. (+)-Tiliarine, a selective in vitro inhibitor of human melanoma cells. Phytother Res. 2002;16:596-9 pubmed
    ..The activity of (+)-tiliarine against the human melanoma cell line was not much modified in the presence of calcium chloride...
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    ..This compound represents the first documented occurrence of an oxoisoaporphine from any Menispermaceae species other than Menispermum dauricum...
  84. Su C, Ueng Y, Dung N, Vijaya Bhaskar Reddy M, Wu T. Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. J Nat Prod. 2007;70:1930-3 pubmed
    ..Among these compounds, palmatine ( 9) and jatrorrhizine ( 10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC 50 values of 0.9 and 2.1 microM, respectively...
  85. Deng W, Luo S, Zhou M, Li N, Chen X, Han L. [The study of anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402]. Zhong Yao Cai. 2008;31:1522-5 pubmed
    ..To study the anti-tumor effect of Tetrandrine (Tet) combined with Nedaplatin (Nap) on the human liver cancer cell line 7402, and explore its mechanism...
  86. Oumarou B, Tchuemdem L, Djomeni P, Bilanda D, Tom E, Ndzana M, et al. Mineral constituents and toxicological profile of Jateorhiza macrantha (Menispermaceae) aqueous extract. J Ethnopharmacol. 2013;149:117-22 pubmed publisher
    ..Jateorhiza macrantha is a medicinal plant used in popular medicine to treat several diseases, including cardiovascular disorders. To date, there is no documented report available on the toxicological profile of this medicinal plant...
  87. Cheng P, Ma Y, Yao S, Zhang Q, Wang E, Yan M, et al. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. Bioorg Med Chem Lett. 2007;17:5316-20 pubmed
    ..b>Menispermaceae) and chemically elucidated through spectral analyses...
  88. He S. [A revision of species and distribution of medicinal plants in Guizhou Province]. Zhongguo Zhong Yao Za Zhi. 2000;25:521-4 pubmed
    To reconfirm the medicinal plants of Aristolochiaceae, Caryophyllaceae, Menispermaceae, Illiciaceae and Magnoliaceae found in Guizhou Province.
  89. Young J, Eid R, Turner C, DeVita R, Kurtz M, Tsao K, et al. Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists. Bioorg Med Chem Lett. 2007;17:5310-5 pubmed
    ..Oxadiazole analog 22 was determined to have excellent hNK(1) binding affinity, functional activity, and a good PD response in vivo...
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    ..The structure of the new alkaloid was elucidated by spectroscopic data analysis...
  91. Freyer A, Huffman J, Menachery M, Huey K, Leavens W, Fitch R. Isolation, structure elucidation, and biological evaluation of 15-amido-3-demethoxy-2alpha,3alpha-methylenedioxyerythroculine, a new alkaloid from Hyperbaena valida. J Nat Prod. 2006;69:1514-6 pubmed
    ..Antagonism of a 100 microM nicotine response was observed for alkaloid 1 (IC50 value of 94 +/- 8 microM) and alkaloid 2 (IC50 value of 77 +/- 19 microM)...
  92. Yokozawa T, Tanaka T, Kimura T. Examination of the nitric oxide production-suppressing component in Tinospora tuberculata. Biol Pharm Bull. 2001;24:1153-6 pubmed
    ..N-trans-Feruloyltyramine isolated from E-3 was identified as exhibiting strong anti-NO activity. This compound is the most active component of Tinospora tuberculata with respect to the suppression of NO production...
  93. Olorunnisola O, Afolayan A. In vivo antioxidant and biochemical evaluation of Sphenocentrum jollyanum leaf extract in P. berghei infected mice. Pak J Pharm Sci. 2013;26:445-50 pubmed
    ..The findings suggest that antioxidant property of Sphenocentrum jollyanum leave extract might be an added advantage to it anti-malarial activity...
  94. Watthanachaiyingcharoen R, Komatsu K, Zhu S, Vajragupta O, Leelamanit W. Authentication of Coscinium fenestratum among the other Menispermaceae plants prescribed in Thai folk medicines. Biol Pharm Bull. 2010;33:91-4 pubmed
    ..material is very rare and is being substituted with substances from Arcangelisia flava or Fibraurea tinctoria (Menispermaceae), which have high morphological similarity...
  95. Hawkes G, De Wet H, Li J. Polar compounds isolated from the leaves of Albertisia delagoensis (Menispermaceae). Molecules. 2011;16:9153-60 pubmed publisher
    Aqueous infusions of the leaves of the shrub Albertisia delagoensis (Menispermaceae) are used in South Africa in traditional Zulu medicine to alleviate a variety of symptoms, including fever, and intestinal problems...