Genomes and Genes
Summary: Virus diseases caused by the ORTHOMYXOVIRIDAE.
Publications283 found, 100 shown here
- The multifunctional NS1 protein of influenza A virusesBenjamin G Hale
Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
J Gen Virol 89:2359-76. 2008....
- Structural and functional bases for broad-spectrum neutralization of avian and human influenza A virusesJianhua Sui
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
Nat Struct Mol Biol 16:265-73. 2009..Our data further suggest that this region is recalcitrant to neutralization escape and that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses...
- A highly conserved neutralizing epitope on group 2 influenza A virusesDamian C Ekiert
Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 333:843-50. 2011..Thus, a cocktail of two antibodies may be sufficient to neutralize most influenza A subtypes and, hence, enable development of a universal flu vaccine and broad-spectrum antibody therapies...
- Endothelial cells are central orchestrators of cytokine amplification during influenza virus infectionJohn R Teijaro
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Cell 146:980-91. 2011..Modulation of endothelium with a specific agonist suggests that diseases in which amplification of cytokine storm is a significant pathological component could be chemically tractable...
- The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNAIrving C Allen
Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Immunity 30:556-65. 2009..Together, these data place the NLRP3 inflammasome as an essential component in host defense against influenza infection through the sensing of viral RNA...
- Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccinesR J Cox
Influenza Research Centre Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
Scand J Immunol 59:1-15. 2004..In contrast, the CAV may elicit a long-lasting, broader immune (humoral and cellular) response, which more closely resembles natural immunity. The immune response induced by these two vaccines will be compared in this review...
- Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infectionDaniela Damjanovic
Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada
Am J Pathol 179:2963-76. 2011..Thus, TNF-α is dispensable for influenza clearance; however, different from the traditional belief, this cytokine is critically required for negatively regulating the extent of lung immunopathology during acute influenza infection...
- Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injuryYumiko Imai
IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
Cell 133:235-49. 2008..Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI...
- Influenza A viruses: new research developmentsRafael A Medina
Department of Microbiology, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine
Nat Rev Microbiol 9:590-603. 2011..We also revise the lessons that have been learnt from the pandemic viruses of the past 100 years...
- Modeling within-host dynamics of influenza virus infection including immune responsesKasia A Pawelek
Department of Mathematics and Statistics, Oakland University, Rochester, Michigan, United States of America
PLoS Comput Biol 8:e1002588. 2012..This study provides a quantitative understanding of the biological factors that can explain the viral and interferon kinetics during a typical influenza virus infection...
- Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virusBalaji Manicassamy
Department of Microbiology, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 107:11531-6. 2010....
- Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infectionBruno Moltedo
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
PLoS Pathog 7:e1002345. 2011..Conversely, this trait may be exploitable by viral pathogens as a mechanism for systemic dissemination...
- IFITM3 restricts the morbidity and mortality associated with influenzaAaron R Everitt
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Nature 484:519-23. 2012..Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans...
- The role of neutrophils during mild and severe influenza virus infections of miceMichelle D Tate
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
PLoS ONE 6:e17618. 2011....
- Genome packaging in influenza A virusEdward C Hutchinson
Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
J Gen Virol 91:313-28. 2010..This review summarizes work leading to this conclusion. In addition, we describe recent progress in identifying the specific packaging signals and discuss likely mechanisms by which these RNA elements might operate...
- Induction of broadly neutralizing H1N1 influenza antibodies by vaccinationChih Jen Wei
Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892 3005, USA
Science 329:1060-4. 2010..Cross-neutralization of H1N1 subtypes elicited by this approach provides a basis for the development of a universal influenza vaccine for humans...
- Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in miceTerrence M Tumpey
Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
J Virol 79:14933-44. 2005....
- Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humansRebecca J Garten
WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
Science 325:197-201. 2009..Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1)...
- Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian hostYuwei Gao
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
PLoS Pathog 5:e1000709. 2009..These amino acids changes in PB2 and HA could serve as important molecular markers for assessing the pandemic potential of H5N1 field isolates...
- Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemicGavin J D Smith
State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
Nature 459:1122-5. 2009..Our results highlight the need for systematic surveillance of influenza in swine, and provide evidence that the mixing of new genetic elements in swine can result in the emergence of viruses with pandemic potential in humans...
- In vitro and in vivo characterization of new swine-origin H1N1 influenza virusesYasushi Itoh
Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
Nature 460:1021-5. 2009..Finally, we show that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic...
- Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1Stephen Mark Tompkins
Food and Drug Administration, Bethesda, Maryland, USA
Emerg Infect Dis 13:426-35. 2007..This M2 prime-boost vaccination conferred broad protection against challenge with lethal influenza A, including an H5N1 strain. Vaccination with M2, with key sequences represented, may provide broad protection against influenza A...
- The ferret as a model organism to study influenza A virus infectionJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Dis Model Mech 4:575-9. 2011..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions...
- Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United StatesMariette F Ducatez
Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 3678, USA
Emerg Infect Dis 17:1624-9. 2011..These novel reassortant viruses highlight the increasing complexity of influenza viruses within pig populations and the frequency at which viral diversification occurs in this ecologically important viral reservoir...
- High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virusAnice C Lowen
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Virol 82:5650-2. 2008..Our data imply that contact or short-range spread predominates in the tropics and offer an explanation for the lack of a well-defined, recurrent influenza season affecting tropical and subtropical regions of the world...
- Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virusT C Dawson
Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7525, USA
Am J Pathol 156:1951-9. 2000....
- Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virusMark W Lamere
Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 186:4331-9. 2011..The high conservation of NP Ag and the known longevity of Ab responses suggest that anti-NP IgG may provide a critically needed component of a universal influenza vaccine...
- IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challengeK Kai McKinstry
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 182:7353-63. 2009..Our results show that IL-10 expression inhibits development of Th17 responses during influenza infection and that this is correlated with compromised protection during high-dose primary, but not secondary, challenge...
- Reassortment of pandemic H1N1/2009 influenza A virus in swineD Vijaykrishna
State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
Science 328:1529. 2010..Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted...
- Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitisTeluguakula Narasaraju
Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
Am J Pathol 179:199-210. 2011..These findings support the pathogenic effects of excessive neutrophils in acute lung injury of influenza pneumonia by instigating alveolar-capillary damage...
- Neutrophils ameliorate lung injury and the development of severe disease during influenza infectionMichelle D Tate
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
J Immunol 183:7441-50. 2009..Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease...
- Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genesCristian Cilloniz
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS Pathog 5:e1000604. 2009....
- Inflammasome recognition of influenza virus is essential for adaptive immune responsesTakeshi Ichinohe
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Exp Med 206:79-87. 2009..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
- Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in miceJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 84:4194-203. 2010..Taken together, these studies demonstrate that the 2009 H1N1 viruses exhibited mild to moderate virulence in mice compared with highly pathogenic viruses...
- Global transmission of influenza viruses from humans to swineMartha I Nelson
Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
J Gen Virol 93:2195-203. 2012....
- Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activityAndrea Jegerlehner
Cytos Biotechnology, Schlieren, Switzerland
J Immunol 172:5598-605. 2004....
- Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and miceTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Science 325:484-7. 2009....
- Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701NJohn Steel
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
PLoS Pathog 5:e1000252. 2009..Thus, our data show that PB2 amino acids 627 and 701 are determinants of mammalian inter-host transmission in diverse virus backgrounds...
- Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virusCarole R Baskin
Washington National Primate Research Center, Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 106:3455-60. 2009....
- Commensal bacteria calibrate the activation threshold of innate antiviral immunityMichael C Abt
Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunity 37:158-70. 2012..Collectively, these data indicate that commensal-derived signals provide tonic immune stimulation that establishes the activation threshold of the innate immune system required for optimal antiviral immunity...
- Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptorJonathan A McCullers
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
J Infect Dis 186:341-50. 2002..The model of lethal synergism will be a useful tool for exploring this and other mechanisms underlying viral-bacterial interactions...
- Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infectionNicole Schmitz
Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
J Virol 79:6441-8. 2005..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection...
- Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infectionKeer Sun
Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, New York 12208, USA
Nat Med 14:558-64. 2008..Thus, IFN-gamma, although probably facilitating induction of specific anti-influenza adaptive immunity, suppresses innate protection against extracellular bacterial pathogens in the lung...
- Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaquesDavid Safronetz
Laboratory of Virology, Hamilton, Montana, USA
J Virol 85:1214-23. 2011..Differences in virulence may explain more severe disease, as was seen with certain individuals infected with the emerged pandemic influenza virus. Thus, the nonhuman primate model closely mimics influenza in humans...
- Host genetic background strongly influences the response to influenza a virus infectionsBarkha Srivastava
Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
PLoS ONE 4:e4857. 2009..The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses...
- Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in miceAnupa Kudva
Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
J Immunol 186:1666-74. 2011..These data indicate a novel mechanism by which influenza A-induced type I IFNs inhibit Th17 immunity and increase susceptibility to secondary bacterial pneumonia...
- Influenza A virus utilizes suboptimal splicing to coordinate the timing of infectionMark A Chua
Microbiology Graduate School Training Program, Mount Sinai School of Medicine, New York, NY 10029, USA
Cell Rep 3:23-9. 2013..Together, these data demonstrate that coordination of the influenza A virus life cycle is set by a "molecular timer" that operates on the inefficient splicing of a virus transcript...
- Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellinJames W Huleatt
VaxInnate Corporation, 300 George Street, New Haven, CT 06511, USA
Vaccine 26:201-14. 2008..These data demonstrate that the linkage of specific TLR ligand with influenza M2e yields a vaccine candidate that offers significant promise for widespread protection against multiple influenza A virus strains...
- Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lungCherrie Lee Small
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
J Immunol 184:2048-56. 2010..aureus phagocytosis by alveolar macrophages. Together, our study identifies the weakened NK cell response in the lung to be a novel critical mechanism for flu-mediated susceptibility to bacterial superinfection...
- Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infectionJohn R Teijaro
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 187:5510-4. 2011..Our results reveal tissue compartmentalization as a major determining factor for immune-mediated protection in a key mucosal site, important for targeting local protective responses in vaccines and immunotherapies...
- Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in miceShigeki Nakamura
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6076, USA
J Clin Invest 121:3657-65. 2011....
- Evolution of novel reassortant A/H3N2 influenza viruses in North American swine and humans, 2009-2011Martha I Nelson
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:8872-8. 2012..The identification of this N2 variant may have implications for influenza vaccine design and the potential pandemic threat of H3N2v to human age groups with differing levels of prior exposure and immunity...
- Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 proteinRonan Le Goffic
Unite de Virologie et Immunologie Moleculaires, UR 892 INRA, Jouy en Josas, France
PLoS Pathog 7:e1002202. 2011..Collectively, these data demonstrate that PB1-F2 strongly influences the early host response during IAV infection and provides new insights into the mechanisms by which PB1-F2 mediates virulence...
- Spatial dynamics of human-origin H1 influenza A virus in North American swineMartha I Nelson
Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 7:e1002077. 2011....
- Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cellsAdrian W S Ho
Immunology Programme, Centre for Life Sciences, National University of Singapore, Singapore 117456
J Immunol 187:6011-21. 2011..Collectively, these results show that CD11b(low/neg)CD103(+) DCs are functionally specialized for the transport of Ag from the lung to the lymph node and also for efficient processing and presentation of viral Ags to CD8 T cells...
- Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferretsVincent J Munster
National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
Science 325:481-3. 2009..These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences...
- Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigsHeui Man Kim
Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305 764, Korea
J Virol 82:4265-74. 2008..Taken together, our findings suggest that alveolar macrophages are essential for controlling H1N1 influenza viruses in pigs...
- Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: infectious potential for humansHuachen Zhu
International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
J Virol 85:10432-9. 2011..Immunization against the 2009 pandemic virus gave only partial protection to ferrets. The continuing prevalence of the pdm/09 virus in pigs could lead to the genesis of novel swine reassortant viruses with the potential to infect humans...
- Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutininsTaia T Wang
Department of Microbiology Mount Sinai School of Medicine New York, New York, United States of America
PLoS Pathog 6:e1000796. 2010..Importantly, our antibodies are of naturally occurring specificity rather than selected from cloned libraries, demonstrating that broad-spectrum humoral immunity to influenza viruses can be elicited in vivo...
- Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferretsJonathan A McCullers
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
J Infect Dis 202:1287-95. 2010..Overall, these data argue that the relationship between respiratory viral infections, acquisition of pneumococci, and development of disease in humans needs further study to be better understood...
- TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infectionJerry R Aldridge
Division of Virology, Department of Infectious Diseases, and Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Proc Natl Acad Sci U S A 106:5306-11. 2009..Targeting the tipDCs in this way thus offers possibilities for therapeutic intervention in the face of a catastrophic pandemic...
- Innate immune responses to influenza A H5N1: friend or foe?Joseph Sriyal Malik Peiris
Department of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam, Hong Kong SAR
Trends Immunol 30:574-84. 2009....
- Are swine workers in the United States at increased risk of infection with zoonotic influenza virus?Kendall P Myers
Center for Emerging Infectious Diseases, Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
Clin Infect Dis 42:14-20. 2006..Pigs have an important role in interspecies transmission of the virus. We examined multiple swine-exposed human populations in the nation's number 1 swine-producing state for evidence of previous swine influenza virus infection...
- Type I IFNs mediate development of postinfluenza bacterial pneumonia in miceArash Shahangian
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Clin Invest 119:1910-20. 2009..Collectively, these findings highlight what we believe to be a novel mechanism by which the antiviral response to influenza sensitizes hosts to secondary bacterial pneumonia...
- Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platformJérôme Denis
Centre de Recherche en Infectiologie, Pavillon CHUL, Universite Laval, 2705 Boulevard Laurier, Quebec, PQ, G1V 4G2 Canada
Vaccine 26:3395-403. 2008..These results show, for the first time, the potential of a recombinant plant virus protein to serve as both peptide delivery system and adjuvant in the crucial field of influenza vaccine development...
- Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanismsJohn R Teijaro
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Virol 84:9217-26. 2010..These findings have important implications for the generation of universal influenza vaccines by promoting long-lived protective CD4 T-cell responses...
- Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypesTaia T Wang
Department of Microbiology and Medicine, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 107:18979-84. 2010..These results provide proof of concept for an HA2-based influenza vaccine that could diminish the threat of pandemic influenza disease and generally reduce the significance of influenza viruses as human pathogens...
- Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic virusesMarkus Mordstein
Department of Virology, University of Freiburg, Freiburg, Germany
PLoS Pathog 4:e1000151. 2008..From these results we conclude that IFN-lambda contributes to inborn resistance against viral pathogens infecting the lung but not the liver...
- Cross-reactive T cells are involved in rapid clearance of 2009 pandemic H1N1 influenza virus in nonhuman primatesJason T Weinfurter
Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America
PLoS Pathog 7:e1002381. 2011..Vaccines capable of inducing such cross-reactive T cells may help protect humans against severe disease caused by newly emerging pandemic influenza viruses...
- Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1Roi Gazit
The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Nat Immunol 7:517-23. 2006..We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus...
- Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in miceRoman Seyer
Institute of Molecular Virology, ZMBE, Muenster, Germany
J Infect Dis 205:262-71. 2012..In conclusion, synergistic action of all 3 mutations results in a mice lethal pandemic H1N1 virus...
- Regulation of antinucleoprotein IgG by systemic vaccination and its effect on influenza virus clearanceMark W Lamere
Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Virol 85:5027-35. 2011..The high conservation of NP antigen and the known longevity of antibody responses suggest that the antiviral activity of anti-NP IgG may provide a critically needed component of a universal influenza vaccine...
- Swine influenza viruses a North American perspectiveAmy L Vincent
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA ARS, Ames, Iowa 50010, USA
Adv Virus Res 72:127-54. 2008....
- Modeling host responses in ferrets during A/California/07/2009 influenza infectionThomas Rowe
International Institute of Infection and Immunity at Shantou Medical College, 22 Xingling Rd, Shantou, Guangdong 515041, People s Republic of China
Virology 401:257-65. 2010..We propose that lung pathology in humans occurs during the innate phase of host immunity and a delay or failure to switch to the adaptive phase may contribute to morbidity and mortality during severe 2009-H1N1 infections...
- Activation of toll-like receptor signaling pathway for protection against influenza virus infectionJ P Wong
Biotechnology Section, Defence R and D Canada Suffield, Ralston, Alberta, Canada
Vaccine 27:3481-3. 2009..Taken together, these results do support the potential role of TLR-3 and TLR-9 agonists such as Poly ICLC and LE Poly ICLC in protection against lethal seasonal and HPAI virus infection...
- Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza virusesMakoto Ozawa
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 575 Science Drive, Madison, WI 53711, USA
J Virol 85:4596-601. 2011..Our results suggest that some NS1 mutations and the newly identified PB1-F2 mutation have the potential to increase the replication and/or pathogenicity of pandemic (H1N1) 2009 influenza viruses...
- Influenza virus aerosol exposure and analytical system for ferretsKortney M Gustin
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 108:8432-7. 2011..These methods will provide improved risk assessment of emerging influenza viruses that pose a threat to public health...
- A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferretsAkila Jayaraman
Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS ONE 6:e17616. 2011..These findings are significant in the context of monitoring the evolution of the currently circulating 2009 H1N1 viruses...
- Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cellsHirokazu Hikono
Trudeau Institute, Saranac Lake, NY 12983, USA
J Exp Med 204:1625-36. 2007..These findings extend our understanding of how recall responses are generated and suggest that activation and migration markers define distinct, and unrelated, characteristics of memory T cells...
- Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in miceAdrianus C M Boon
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Virol 83:10417-26. 2009..One of the validated genes, the hemolytic complement gene, affected virus titer 7 days after infection. We conclude that H5N1 influenza virus-induced pathology is affected by a complex and multigenic host component...
- Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2Krystyna Mozdzanowska
Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 4268, USA
Vaccine 21:2616-26. 2003..Importantly, the protection in M2e-MAP- and infection-immunized mice appeared to be mediated by distinct immune mechanisms. This suggests that stronger protection may be achievable by combining both protective activities...
- Intra- and interhost evolutionary dynamics of equine influenza virusPablo R Murcia
Cambridge Infectious Diseases Consortium, Department of Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES Cambridge, England, United Kingdom
J Virol 84:6943-54. 2010....
- Antiviral activity of the long chain pentraxin PTX3 against influenza virusesPatrick C Reading
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 180:3391-8. 2008....
- The epidemiology and evolution of influenza viruses in pigsI H Brown
Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, UK
Vet Microbiol 74:29-46. 2000..Both human H3N2 and avian H1N1 were detected in pigs many years before they acquired the ability to spread rapidly and become associated with disease epidemics in pigs...
- Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumoniaJulie L McAuley
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cell Host Microbe 2:240-9. 2007..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
- Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus releaseRahul K Nelli
School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, United Kingdom
J Virol 86:9201-10. 2012....
- Influenza A virus infection dynamics in swine farms in Belgium, France, Italy and Spain, 2006-2008C S Kyriakis
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Vet Microbiol 162:543-50. 2013..This can either be explained by the persistence of the virus in a farm, or by the periodical re-introduction of SIVs of the same subtype...
- Genomic characterization of H1N2 swine influenza viruses in ItalyAna Moreno
Department of Virology, Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna, Via Bianchi, 9, 25124 Brescia, Italy
Vet Microbiol 156:265-76. 2012..These findings also highlighted different genomic characteristics of the NA gene the recent Italian strains compared to circulating European viruses...
- Emergence of fatal avian influenza in New England harbor sealsS J Anthony
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
MBio 3:e00166-12. 2012..The emergence of this A/harbor seal/Massachusetts/1/2011 virus may herald the appearance of an H3N8 influenza clade with potential for persistence and cross-species transmission...
- Critical role of airway macrophages in modulating disease severity during influenza virus infection of miceMichelle D Tate
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Virol 84:7569-80. 2010..Furthermore, the inability of PR8 to infect airway macrophages may be a critical factor contributing to its virulence for mice...
- Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signalingLinda M Bradley
Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
PLoS Pathog 8:e1002641. 2012....
- A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virusDamian M Carragher
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 181:4168-76. 2008..These results suggest that vaccines designed to elicit optimal heterosubtypic immunity to influenza should promote both Ab and T cell responses to conserved internal proteins...
- Evolution of an Eurasian avian-like influenza virus in naïve and vaccinated pigsPablo R Murcia
Cambridge Infectious Diseases Consortium, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
PLoS Pathog 8:e1002730. 2012..This implies that mutations that reduce viral fitness in one host, but which could lead to fitness benefits in a novel host, can circulate at low frequencies...
- Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virusHongyu Miao
Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 146421, USA
J Virol 84:6687-98. 2010..Also, simulation studies were performed to understand the relative contributions of biological parameters to IAV clearance. This study provides a basis to better understand and predict influenza virus immunity...
- Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challengeB S Bender
Department of Medicine, University of Florida College of Medicine, Gainesville
J Exp Med 175:1143-5. 1992..Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections...
- Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infectionAmanda M Jamieson
Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Cell Host Microbe 7:103-14. 2010..This study demonstrates that activation of the hypothalamic-pituitary-adrenal axis controls the balance between immune defense and immunopathology and is an important component of the host response to coinfection...
- Long-term evolution and transmission dynamics of swine influenza A virusDhanasekaran Vijaykrishna
State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
Nature 473:519-22. 2011..Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans...
- Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 inductionNicholas Svitek
INRS Institut Armand Frappier, University of Quebec, Laval, QC, Canada
Virology 376:53-9. 2008..These findings suggest that more virulent strains may interfere more efficiently with the host response at early disease stages...
- Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigsSharon M Brookes
Veterinary Laboratories Agency Weybridge, EU OIE FAO Reference Laboratory for Avian Influenza and Newcastle Disease, Addlestone, Surrey, United Kingdom
PLoS ONE 5:e9068. 2010..These findings provide potential clues to the existence and biological significance of viral receptor-binding variants with 225D and 225G during the 1918 pandemic ...
- The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cellsKaren Y Twu
Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA
J Virol 81:8112-21. 2007..Consequently, these internal HK97 proteins largely compensate for the absence of F103 and M106, presumably by stabilizing the NS1A-CPSF30 complex...
- IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infectionKoenraad F Van Der Sluijs
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
J Immunol 172:7603-9. 2004..This increased susceptibility to secondary bacterial pneumonia is at least in part caused by excessive IL-10 production and reduced neutrophil function in the lungs...
- Lethal synergism between influenza and pneumococcusJonathan McCullers; Fiscal Year: 2003....
- Synergism Between Influenza Virus and PneumococcusJonathan McCullers; Fiscal Year: 2009....
- Influenza-pneumococcal synergism: role of neuraminidaseJonathan McCullers; Fiscal Year: 2004....
- 2nd Orthomyxoviruses Research ConferenceJonathan McCullers; Fiscal Year: 2003..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
- 3rd Orthomyxoviruses Research ConferenceJonathan McCullers; Fiscal Year: 2005..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
- Early Regulation of Immunity in the Respiratory TractNicole Baumgarth; Fiscal Year: 2007..This information could help the development of novel interventions that utilize early respiratory tract defenses for immune protection. [unreadable] [unreadable]..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
- Advances in Influenza Research - From Birds to Bench to BedsideDAVID WOODLAND; Fiscal Year: 2006..The goal of this meeting is to bring together virologists, immunologists and vaccine researchers to discuss recent advances in influenza research and to develop better measures to prevent and control influenza. ..
- Novel broad spectrum vaccination against influenzaPetr Ilyinskii; Fiscal Year: 2006..The overall aim of this project is to demonstrate better protective effect or/and enhanced immune response using modified influenza proteins as immunogens compared to wild-type viral proteins. ..
- T CELL RECOGNITION OF BACTERIAL SUPERANTIGENSDAVID WOODLAND; Fiscal Year: 2002..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
- CD4+T cell immunity to respiratory virus infectionsDAVID WOODLAND; Fiscal Year: 2004....
- CELL MEDIATED IMMUNITY TO SENDAI VIRUSDAVID WOODLAND; Fiscal Year: 2001....
- Modification of Conserved Influenza Genes Enabling their Elevated ExpressionPetr Ilyinskii; Fiscal Year: 2008..Therefore, if proven, our approach will lead to a novel paradigm for recombinant gene modifications for enhanced expression in vivo, both for vaccine and non-vaccine applications. [unreadable] [unreadable] [unreadable]..
- Memory T cell subsets and pulmonary immunityDavid L Woodland; Fiscal Year: 2010....
- Regulation of CD8+ T cell responses to influenza virusDAVID WOODLAND; Fiscal Year: 2007..abstract_text> ..
- TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURYMICHAEL O REILLY; Fiscal Year: 2002..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
- Host range restriction of human influenza virusesChristopher Olsen; Fiscal Year: 2009..abstract_text> ..
- ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICELINDA TOTH; Fiscal Year: 2006..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
- MEASLES VIRUS STUDIES IN A TRANSGENIC MODELMichael Oldstone; Fiscal Year: 2007..abstract_text> ..
- Dissecting 3 processing pathways that generate class II-restricted flu epitopesLaurence Eisenlohr; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- IMPACT OF EPITOPE DENSITY ON TCD8, ACTIVATION AND MEMORYLaurence Eisenlohr; Fiscal Year: 2003..He believes that the pursuit of these aims will provide fundamentally important information about TCD8+-mediated immunity and will put us in a strong position to address the next generation of questions that will be facing the field. ..
- Human Metapneumovirus in High Risk PopulationsGregory Gray; Fiscal Year: 2005..These data will facilitate the development of more comprehensive epidemiological studies, and guide future intervention studies in reducing HMPV morbidity. ..
- Accelerated Viral Inhibition AssayMaryna Eichelberger; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Population-based Surveillance for Zoonotic Influenza AGregory Gray; Fiscal Year: 2005..We are particularly well suited to conduct this work as we have extensive experience conducting both epidemiological and laboratory-based studies of respiratory pathogens. ..
- Aging Disease--Prion/Transgenic/Immunologic StudiesMichael Oldstone; Fiscal Year: 2008..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
- Class II Processing Delineated by Flu GlycoproteinsLaurence Eisenlohr; Fiscal Year: 2008..abstract_text> ..
- Viruses and DiabetesMichael Oldstone; Fiscal Year: 2005....
- The Role of the RET Receptor in Autoimmune DiseaseLaurence Eisenlohr; Fiscal Year: 2007..By deciphering the role of RETECD antibody in disease, we can design improved methods and drugs for the abrogation of thyroid and other organ-specific autoimmune disorders. [unreadable] [unreadable] [unreadable]..
- STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASEMichael Oldstone; Fiscal Year: 2001..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
- VIRUSES AND AUTOIMMUNE DISEASEMichael Oldstone; Fiscal Year: 2001..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
- Therapeutics to Prevent/Treat Lassa Fever VirusMichael B Oldstone; Fiscal Year: 2010..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
- The Basis for MHC Class II-restricted proteasome-dependent epitopesLAURENCE CRANE EISENLOHR; Fiscal Year: 2010..Execution of the plan could fundamentally alter the general perception of CD4+ T cell responses and the roles they play in protection, thereby strongly influencing the design of future vaccines. ..
- Pathogenesis Studies in Scrapie (TSE Diseases)Michael Oldstone; Fiscal Year: 2003..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
- Arenavirus Receptor-Structure/Function StudiesMichael B Oldstone; Fiscal Year: 2010..These findings have relevance for biodefense of several viruses including LFV. ..
- Recruitment of memory CD8+ T cells to the lung airwaysJACOB KOHLMEIER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Lymphocyte Exit from Tissues: Control and Significance to Host DefenseGUDRUN DEBES; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Lassa and Nipah Virus Interferon-AntagonistsCHRISTOPHER BASLER; Fiscal Year: 2003..abstract_text> ..
- BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICELINDA TOTH; Fiscal Year: 2006..abstract_text> ..
- INITIATION OF VIRUS SPECIFIC CD8+ T CELL RESPONSESMaryna Eichelberger; Fiscal Year: 2002..This proposal is designed as an essential step towards the development of more effective influenza vaccine. ..
- Facility renovation to expand mouse barrier spaceLINDA TOTH; Fiscal Year: 2005..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
- EBOLA VIRUS INTERFERON-ANTAGONISTS AND VIRULENCECHRISTOPHER BASLER; Fiscal Year: 2003..VP35 and VP24 may also prove to be attractive targets for new antiviral agents. Inhibition of anti-IFN factors may sensitize Ebola virus infected cells to the antiviral effects of IFN and may also enhance the effect of antiviral agents. ..
- Sleep and fatigue during renal disease in miceLINDA TOTH; Fiscal Year: 2008..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..
- Lethality of H5N1 Influenza Virus is Linked to TGF-betaStacey Schultz Cherry; Fiscal Year: 2009..These studies provide a unique opportunity to understand the cellular and immunological basis of H5N1 influenza virus virulence in mammals: currently, an unexplored area of investigation. ..
- Encapsidation of Adenovirus DNAMichael J Imperiale; Fiscal Year: 2010..This knowledge will be applicable to the development of anti-viral drugs that block this process, as well as to the development of safer adenovirus vectors and recombinant vaccines. ..
- Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A VirusesPeter C Doherty; Fiscal Year: 2010..These studies should allow us to develop a clear, mechanistic understanding of how to promote effective CMI against the H5N1 viruses. ..
- MOLECULAR MECHANISMS OF INFLUENZA PANDEMICSYoshihiro Kawaoka; Fiscal Year: 2008..Collectively, these studies will help to elucidate the mechanism(s) underlying the emergence of new (pandemic) influenza A virus lineages, a crucial step in combating future threats from this virus. [unreadable] [unreadable] [unreadable]..
- Molecular Pathogenesis of Ebolavirus InfectionYoshihiro Kawaoka; Fiscal Year: 2010..By advancing knowledge of likely determinants of Ebolavirus pathogenicity, we expect to provide compelling new rationales for vaccine and targeted drug development. ..
- INFLUENZA VIRUS ASSEMBLYYoshihiro Kawaoka; Fiscal Year: 2009..abstract_text> ..
- Innate Immunity to Influenza in Caloric Restricted Aged MiceElizabeth Gardner; Fiscal Year: 2007..CR mice will be fed AL diets to restore weight to 50% and 100% of AL mice before infection with influenza and outcomes in Specific Aims 1 and 2 will be assessed. [unreadable] [unreadable] [unreadable]..
- TRANSFECTANT INFLUENZA VIRUSES IN CANCER THERAPYAdolfo Garcia Sastre; Fiscal Year: 2002..The proposed research may advance the field of cancer therapy towards possible novel ways to treat human tumors and prolong survival of cancer patients. ..
- Vulnerability to Smallpox Due to Declining CTL ImmunityInnocent Mbawuike; Fiscal Year: 2003..By correlating these responses with vaccinia lesion sizes in new vaccinees, markers of severe complications from vaccinia vaccination may be identified. ..
- Molecular Basis for Ebola Virus PathogenicityYoshihiro Kawaoka; Fiscal Year: 2007..Ultimately, the information gained could be exploited in the development of antiviral compounds and effective vaccines. ..
- CD8+ T cell trafficking to the normal lungThomas Braciale; Fiscal Year: 2007..abstract_text> ..
- ARSENIC, OXIDATIVE STRESS, AND TRANSCRIPTIONAL CONTROLMiroslav Styblo; Fiscal Year: 2002....
- Mechanism of Arsenic-Induced DiabetesMiroslav Styblo; Fiscal Year: 2002....
- Pathogenesis of Infectious in Swine with Pathogenic Avian Influenza VirusesBH JANKE; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- MECHANISM OF DIFFERENTIATION OF FUNCTION OF CD80 & CD86MICHAEL AGADJANYAN; Fiscal Year: 2004..5). The differential expression of genes after ligation of CD86 versus CD80 on muscle cells and professional APC. ..
- Exercise & influenza immunity:Psychoneuroendocrine ModelMarian Kohut; Fiscal Year: 2004..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..
- Antigen-specific CD4+ T cell responses to influenzaPaul Thomas; Fiscal Year: 2007..Finally, the effects of antigen-specific vs. unrelated antigen priming by influenza on allergic responses on different genetic backgrounds will be examined. ..
- EXPERIMENTAL AUTOIMMUNE GRAVES' DISEASEBellur Prabhakar; Fiscal Year: 2003..Such a model would facilitate a thorough understanding of the regulation of the immune response to TSHR with implications for the development of novel therapeutics. ..
- Microarray Analysis of Translational Regulatory PathwaysMichael Katze; Fiscal Year: 2003..The proposed studies make use of technologies not available at the time of the parent grant award and will allow us to capitalize on recent findings and extend our studies in new directions. ..
- XRAY STUDIES OF EPO AND IL2 RECEPTOR COMPLEXESIan Wilson; Fiscal Year: 2001..The crystallographic study of IL-2 mutants and various forms of the receptor complex should give insights into the structure and function of this key receptor in T cell growth and proliferation. ..
- HEPATITIS C VIRUS AND INTERFERON--CONTROL OF PKR BY NS5AMichael Katze; Fiscal Year: 2001..3) Identification of NS5A phosphorylation sites in vivo. The importance of such sites for NS5A function will be examined by site-directed mutagenesis. ..
- Induction of tolerance to islet cell transplantsBellur Prabhakar; Fiscal Year: 2004..Under aim 3: we will prepare a new BiAb using an islet cell specific antibody and anti-CTLA-4 antibody to test ability to prevent and treat Type I DM in a murine model of spontaneous diabetes. ..
- X-ray structures of HIV-1 neutralizing sitesIan Wilson; Fiscal Year: 2008..These studies all have the common goal of providing essential structural information on HIV-1 proteins and anti-HIV-1 antibodies to help guide efforts in vaccine and inhibitor design. [unreadable] [unreadable]..
- HEPATITIS C VIRUS:PATHOGENESIS AND CELLULAR SIGNALINGMichael Katze; Fiscal Year: 2005..Identification of the kinase will likely help decipher the detailed molecular pathways uncovered from these studies. These studies may contribute to the identification of novel cellular gene targets for anti-HCV therapeutics. ..
- GENE EXPRESSION PROFILING OF AIDS VACCINE STRATEGIESMichael Katze; Fiscal Year: 2007..Ultimately, these studies may also suggest mechanisms to enhance current AIDS vaccine strategies. [unreadable] [unreadable] [unreadable]..
- TRANSLATIONAL CONTROL IN INFLUENZA VIRUS INFECTED CELLSMichael Katze; Fiscal Year: 2009..The identification of host pathways impacted by influenza virus should reveal novel therapeutic targets and lead to improved antiviral therapies and vaccines. ..
- Becton Dickinson Flow Cytometry SystemBellur Prabhakar; Fiscal Year: 2002..Careful evaluation of the three available systems prompted our users group to recommend the BD FACS Vantage SE since it would satisfy the needs of our institution's NIH-funded investigators. ..
- Novel human gene-IG20-potential role in cancer therapyBellur Prabhakar; Fiscal Year: 2009..These studies will lead to a clearer understanding of the mechanism of action of IG20/DENN-SV in ovarian cancer. ..