Genomes and Genes
Summary: A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications340 found, 100 shown here
- European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac diseaseS Husby
Hans Christian Andersen Children s Hospital at Odense University Hospital
J Pediatr Gastroenterol Nutr 54:136-60. 2012....
- The Oslo definitions for coeliac disease and related termsJonas F Ludvigsson
Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Gut 62:43-52. 2013..The literature suggests a lack of consensus on the use of terms related to coeliac disease (CD) and gluten...
- Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac diseaseGosia Trynka
Genetics Department, University Medical Center and University of Groningen, The Netherlands
Nat Genet 43:1193-201. 2011..genotyped 183 non-HLA risk loci previously associated with immune-mediated diseases in 12,041 individuals with celiac disease (cases) and 12,228 controls...
- Multiple common variants for celiac disease influencing immune gene expressionPatrick C A Dubois
Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Nat Genet 42:295-302. 2010We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects...
- Celiac diseasePeter H R Green
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
N Engl J Med 357:1731-43. 2007
- ACG clinical guidelines: diagnosis and management of celiac diseaseAlberto Rubio-Tapia
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
Am J Gastroenterol 108:656-76; quiz 677. 2013This guideline presents recommendations for the diagnosis and management of patients with celiac disease. Celiac disease is an immune-based reaction to dietary gluten (storage protein for wheat, barley, and rye) that primarily affects the ..
- Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter studyAlessio Fasano
Center for Celiac Research, University of Maryland School of Medicine, 22 S Greene St, N5W70, PO Box 140, Baltimore, MD 21201 1595, USA
Arch Intern Med 163:286-92. 2003b>Celiac disease (CD) is an immune-mediated enteropathic condition triggered in genetically susceptible individuals by the ingestion of gluten...
- Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigensR W Depaolo
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Nature 471:220-4. 2011..Altogether, these findings reveal an unexpected role for retinoic acid and IL-15 in the abrogation of tolerance to dietary antigens...
- Spectrum of gluten-related disorders: consensus on new nomenclature and classificationAnna Sapone
Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
BMC Med 10:13. 2012A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals...
- Celiac disease: from pathogenesis to novel therapiesDetlef Schuppan
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Gastroenterology 137:1912-33. 2009b>Celiac disease has become one of the best-understood HLA-linked disorders...
- Increasing prevalence of coeliac disease over timeS Lohi
Paediatric Research Center, Medical School, University of Tampere, Tampere, Finland
Aliment Pharmacol Ther 26:1217-25. 2007..The number of coeliac disease diagnoses has increased in the recent past and according to screening studies, the total prevalence of the disorder is around 1%...
- Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac diseaseIsabel Comino
Departamento de Microbiologia y Parasitologia, Facultad de Farmacia, Universidad de Sevilla, C Profesor García González, Spain
Gut 60:915-22. 2011..The stated aim of this study is to test whether this observed reactivity could be related to the potential toxicity of oats for patients with CD...
- Evidence of high sugar intake, and low fibre and mineral intake, in the gluten-free dietD Wild
Academic Unit of Medicine, St James s University Hospital, Leeds LS97TF, UK
Aliment Pharmacol Ther 32:573-81. 2010..The only therapy for coeliac disease (CD) is a long-term gluten-free diet (GFD). Little is known about the detailed composition of such a diet...
- Delay to celiac disease diagnosis and its implications for health-related quality of lifeFredrik Norström
Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umea University, Umea, Sweden
BMC Gastroenterol 11:118. 2011To determine how the delay in diagnosing celiac disease (CD) has developed during recent decades and how this affects the burden of disease in terms of health-related quality of life (HRQoL), and also to consider differences with respect ..
- From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseasesVinod Kumar
Department of Genetics, University Medical Hospital Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
Semin Immunopathol 34:567-80. 2012b>Celiac disease is characterized by a chronic inflammatory reaction in the intestine and is triggered by gluten, a constituent derived from grains which is present in the common daily diet in the Western world...
- Coeliac diseaseAntonio Di Sabatino
First Department of Medicine, Centro per lo Studio e la Cura della Malattia Celiaca, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
Lancet 373:1480-93. 2009..In this Seminar we critically reassess the clinical and diagnostic aspects of this disease and new perspectives in its pathogenesis and treatment...
- Intraepithelial lymphocytes in celiac disease immunopathologyValérie Abadie
Sainte Justine Hospital Research Centre, Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, Montreal, QC, H3T 1C5, Canada
Semin Immunopathol 34:551-66. 2012b>Celiac disease is a T cell-mediated immune disorder induced by dietary gluten that is characterized by the development of an inflammatory anti-gluten CD4 T cell response, anti-gluten antibodies, and autoantibodies against tissue ..
- The prevalence of celiac disease in the United StatesAlberto Rubio-Tapia
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Gastroenterol 107:1538-44; quiz 1537, 1545. 2012The prevalence of celiac disease (CD) in the United States is unknown. We sought to estimate CD prevalence nationwide by using a nationally representative sample.
- Integration of genetic and immunological insights into a model of celiac disease pathogenesisValérie Abadie
Department of Medicine, University of Chicago, Illinois 60637, USA
Annu Rev Immunol 29:493-525. 2011b>Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically susceptible individuals by exposure to cereal gluten proteins...
- The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic reviewCatherine Dube
Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Ontario, Canada
Gastroenterology 128:S57-67. 2005Until recently, celiac disease (CD) was felt to be a rare disease in the United States. The aim of this study was to conduct a systematic review of the prevalence of CD in general Western populations and in populations at high risk for CD...
- Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared lociAlexandra Zhernakova
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
PLoS Genet 7:e1002004. 2011Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored...
- Tissue-mediated control of immunopathology in coeliac diseaseBana Jabri
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Nat Rev Immunol 9:858-70. 2009....
- Gluten-free diet and quality of life in patients with screen-detected celiac diseaseKirsi Mustalahti
Department of Pediatrics, Tampere University Hospital, Finland
Eff Clin Pract 5:105-13. 2002Since the advent of serologic testing for celiac disease, most persons who receive a diagnosis of celiac disease have few or no symptoms...
- Alterations in intestinal permeabilityM C Arrieta
Department of Medicine, University of Alberta, Alberta, Canada
Gut 55:1512-20. 2006
- Shared and distinct genetic variants in type 1 diabetes and celiac diseaseDeborah J Smyth
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
N Engl J Med 359:2767-77. 2008Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin...
- The prevalence of celiac disease in Europe: results of a centralized, international mass screening projectKirsi Mustalahti
Paediatric Research Centre, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
Ann Med 42:587-95. 2010Although the prevalence of celiac disease (CD) has been extensively investigated in recent years, an accurate estimate of CD frequency in the European population is still lacking...
- Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and NutritionIvor D Hill
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
J Pediatr Gastroenterol Nutr 40:1-19. 2005b>Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals...
- Increasing incidence of celiac disease in a North American populationJonas F Ludvigsson
Division of Gastroenterology and Hepatology, Departments of Medicine and Immunology, College of Medicine, Mayo Clinic, Rochester, MN, USA
Am J Gastroenterol 108:818-24. 2013The prevalence of celiac disease (CD) varies greatly, potentially because of incomplete ascertainment of cases and small study samples with limited statistical power. Previous reports indicate that the incidence of CD is increasing...
- Celiac disease revealed in 3% of Swedish 12-year-olds born during an epidemicAnna Myléus
Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences, Umea University, Umea, Sweden
J Pediatr Gastroenterol Nutr 49:170-6. 2009Sweden experienced a marked epidemic of celiac disease between 1984 and 1996 in children younger than 2 years of age, partly explained by changes in infant feeding...
- The incidence and clinical spectrum of refractory celiac disease in a north american referral centerBakht Roshan
Department of Gastroenterology, Celiac Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Gastroenterol 106:923-8. 2011Refractory celiac disease (RCD) is one of the most serious causes of persistent symptoms in patients with celiac disease (CD)...
- Body mass index and the risk of obesity in coeliac disease treated with the gluten-free dietT A Kabbani
Department of Medicine and Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Aliment Pharmacol Ther 35:723-9. 2012..Coeliac disease is increasingly diagnosed and weight changes are common after adoption of a gluten-free diet (GFD), however data on body mass index (BMI) changes are limited...
- Gliadin-mediated proliferation and innate immune activation in celiac disease are due to alterations in vesicular traffickingM Vittoria Barone
Department of Pediatrics, European Laboratory for the Investigation of Food Induced Diseases, University of Naples Federico II, Naples, Italy
PLoS ONE 6:e17039. 2011Damage to intestinal mucosa in celiac disease (CD) is mediated both by inflammation due to adaptive and innate immune responses, with IL-15 as a major mediator of the innate immune response, and by proliferation of crypt enterocytes as an ..
- HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22M Bodd
Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
Mucosal Immunol 3:594-601. 2010..of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4(+) T cells of celiac disease patients, either cultured from small intestinal biopsies or isolated from peripheral blood after an oral ..
- Association between innate response to gliadin and activation of pathogenic T cells in coeliac diseaseLuigi Maiuri
Institute of Child Health, University College London, London, UK
Lancet 362:30-7. 2003..We investigated whether gliadin, a protein present in wheat flour, could activate an innate as well as an adaptive immune response in patients with coeliac disease...
- Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformisMiklós Sárdy
Department of Dermato Venereology, Semmelweis University, H 1085 Budapest, Maria u 41, Hungary
J Exp Med 195:747-57. 2002Gluten sensitivity typically presents as celiac disease, a common chronic small intestinal disorder...
- Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac diseaseJurgen Glas
Department of Medicine II, Grosshadern, Ludwig Maximilians University, Munich, Germany
Am J Gastroenterol 104:1737-44. 2009..polymorphisms (SNPs) in the chromosome 4q27 region containing IL2 and IL21 are associated with celiac disease. Given the increased prevalence of inflammatory bowel disease (IBD) among celiac disease patients, we ..
- Changes of body mass index in celiac children on a gluten-free dietP Brambilla
Italian Federation of Family Pediatricians FIMP, Department of Continuing Medical Education, Area Lombardia, Italy
Nutr Metab Cardiovasc Dis 23:177-82. 2013Studies of adults and children with celiac disease (CD) performed mostly in tertiary care centers have reported an increased risk of overweight during gluten-free diet (GFD)...
- Celiac disease: prevalence, diagnosis, pathogenesis and treatmentNaiyana Gujral
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada
World J Gastroenterol 18:6036-59. 2012b>Celiac disease (CD) is one of the most common diseases, resulting from both environmental (gluten) and genetic factors [human leukocyte antigen (HLA) and non-HLA genes]. The prevalence of CD has been estimated to approximate 0...
- The diagnostic accuracy of serologic tests for celiac disease: a systematic reviewAlaa Rostom
Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Canada
Gastroenterology 128:S38-46. 2005Clinicians are increasingly utilizing noninvasive serologic tests for the diagnosis and screening of celiac disease (CD)...
- Systematic review: tolerable amount of gluten for people with coeliac diseaseA K Akobeng
Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
Aliment Pharmacol Ther 27:1044-52. 2008..The threshold amount of gluten in 'gluten-free' products that can be tolerated by people with coeliac disease is unclear...
- Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free dietA Lanzini
Gastroenterology Unit, University and Spedali Civili of Brescia, Brescia, Italy
Aliment Pharmacol Ther 29:1299-308. 2009..Expected benefits of gluten-free diet (GFD) in coeliac patients include healing of small intestinal mucosa, but it remains unclear to what extent this benefit is achieved in adults...
- Molecular and immunological characterization of gluten proteins isolated from oat cultivars that differ in toxicity for celiac diseaseAna Real
Departamento de Microbiologia y Parasitologia, Universidad de Sevilla, Sevilla, Spain
PLoS ONE 7:e48365. 2012A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease (CD)...
- Celiac disease: an immunological jigsawBertrand Meresse
INSERM, U989, Universite Paris Descartes, Paris Sorbonne Centre, Institut Imagine, Paris, France
Immunity 36:907-19. 2012b>Celiac disease (CD) is a chronic enteropathy induced by dietary gluten in genetically predisposed people...
- Body mass index in celiac disease: beneficial effect of a gluten-free dietJianfeng Cheng
Department of Medicine, Sound Shore Medical Center of Westchester, New Rochelle, NY, USA
J Clin Gastroenterol 44:267-71. 2010There is concern about celiac disease patients being overweight and gaining more weight while on a gluten-free diet (GFD).
- New clues in celiac disease epidemiology, pathogenesis, clinical manifestations, and treatmentElena Lionetti
Department of Pediatrics, University of Catania, Catania, Italy
Int Rev Immunol 30:219-31. 2011b>Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. It is one of the most common lifelong disorders on a worldwide basis...
- A genetic perspective on coeliac diseaseGosia Trynka
Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
Trends Mol Med 16:537-50. 2010....
- Psoriasis in a nationwide cohort study of patients with celiac diseaseJonas F Ludvigsson
Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
J Invest Dermatol 131:2010-6. 2011Earlier studies on the association between celiac disease (CD) and psoriasis show contradictory results. The purpose of this study was to assess the risk of psoriasis in patients with biopsy-verified CD...
- Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac diseaseMichael Schumann
Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charite Berlin, Berlin, Germany
Gut 61:220-8. 2012..Epithelial barrier defects are well known in coeliac disease, but the mechanisms are only poorly defined. It is unclear, whether barrier disturbance reflects upregulated epithelial transcytosis or paracellular leakage...
- Characterization of gliadin-specific Th17 cells from the mucosa of celiac disease patientsSilvia Fernandez
Unidad de Inmunologia, Facultad de Medicina, Universidad de Cordoba, Cordoba, Spain
Am J Gastroenterol 106:528-38. 2011b>Celiac disease (CD) is a disorder characterized by a deregulated immune response to ingested wheat gluten and related cereal proteins in susceptible individuals...
- Coeliac disease, autoimmune diseases and gluten exposureMervi Viljamaa
Department of Internal Medicine, Tampere University Hospital, Finland
Scand J Gastroenterol 40:437-43. 2005..The aim here was to investigate the occurrence of autoimmune disorders in relation to gluten intake in coeliac patients in a well-defined area...
- Gluten-free diet and autoimmune thyroiditis in patients with celiac disease. A prospective controlled studySaara Metso
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Scand J Gastroenterol 47:43-8. 2012..dietary treatment with a gluten-free diet might slow down the progression of associated autoimmune diseases in celiac disease, but the data are contradictory...
- Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3Karen M Lammers
Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Gastroenterology 135:194-204.e3. 2008b>Celiac disease is an immune-mediated enteropathy triggered by gliadin, a component of the grain protein gluten...
- Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based studyMarjorie M Walker
Department of Histopathology, Faculty of Medicine, St Mary s Campus, Imperial College London, London, United Kingdom
Gastroenterology 139:112-9. 2010Although serologic analysis is used in diagnosis of celiac disease, histopathology is considered most reliable...
- Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trialJessica R Biesiekierski
Monash University Department of Medicine and Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
Am J Gastroenterol 106:508-14; quiz 515. 2011..increased prescription of a gluten-free diet for gastrointestinal symptoms in individuals who do not have celiac disease, there is minimal evidence that suggests that gluten is a trigger...
- HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac DiseaseKati Karell
Department of Tissue Typing, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
Hum Immunol 64:469-77. 2003Genetic susceptibility to celiac disease is strongly associated with HLA-DQA1*05-DQB1*02 (DQ2) and HLA-DQA1*03-DQB1*0302 (DQ8)...
- A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac diseaseEleonora A M Festen
Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
PLoS Genet 7:e1001283. 2011Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis...
- Molecular basis of celiac diseaseL M Sollid
Institute of Immunology, Rikshospitalet, University of Oslo, Norway
Annu Rev Immunol 18:53-81. 2000b>Celiac disease (CD) is an intestinal disorder with multifactorial etiology. HLA and non-HLA genes together with gluten and possibly additional environmental factors are involved in disease development...
- Increased prevalence and mortality in undiagnosed celiac diseaseAlberto Rubio-Tapia
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Gastroenterology 137:88-93. 2009The historical prevalence and long-term outcome of undiagnosed celiac disease (CD) are unknown. We investigated the long-term outcome of undiagnosed CD and whether the prevalence of undiagnosed CD has changed during the past 50 years.
- Breast-feeding protects against celiac diseaseAnneli Ivarsson
Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden
Am J Clin Nutr 75:914-21. 2002b>Celiac disease, or permanent gluten-sensitive enteropathy, is an immunologic disease strictly dependent on exposure to wheat gluten or related proteins in rye and barley.
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signallingG Trynka
Genetics Department, University Medical Centre, University of Groningen, Groningen, The Netherlands
Gut 58:1078-83. 2009..To identify more coeliac disease loci, we selected 458 single nucleotide polymorphisms (SNPs) that showed more modest association in the GWAS for genotyping and analysis in four independent cohorts...
- Prevalence of Celiac disease among children in FinlandMarkku Maki
Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
N Engl J Med 348:2517-24. 2003Wheat, rye, and barley proteins induce celiac disease, an autoimmune type of gastrointestinal disorder, in genetically susceptible persons...
- A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac diseaseCarlo Catassi
Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Clin Nutr 85:160-6. 2007Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients.
- HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typingFrancesca Megiorni
Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324 Rome, Italy
J Biomed Sci 19:88. 2012b>Celiac disease (CD) is a multifactorial disorder with an estimated prevalence in Europe and USA of 1:100 and a female:male ratio of approximately 2:1...
- Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell linesSandro Drago
Mucosal Biology Research Center, Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Scand J Gastroenterol 41:408-19. 2006..We investigated whether gliadin has any immediate effect on zonulin release and signaling...
- Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the Continuous National Health and Nutrition Examination Survey 2009-2010Daniel V Digiacomo
Department of Medicine, Celiac Disease Center at Columbia University, Columbia University, New York, NY 10032, USA
Scand J Gastroenterol 48:921-5. 2013..Clinical inference suggests the prevalence of non-celiac gluten sensitivity is substantially higher than that of celiac disease in the USA. Unfortunately, there are currently no data supporting these claims...
- Oats to children with newly diagnosed coeliac disease: a randomised double blind studyL Hogberg
Department of Paediatrics, Norrköping Hospital, Sweden
Gut 53:649-54. 2004..Recent studies, mainly in adults, have shown that oats are non-toxic to CD patients. In children, only open studies comprising a small number of patients have been performed...
- Epidemic of coeliac disease in Swedish childrenA Ivarsson
Department of Clinical Science, Umea University, Sweden
Acta Paediatr 89:165-71. 2000..e. amount of gluten given, age at introduction of gluten, and whether breastfeeding was ongoing or not when gluten was introduced. Other factor(s) may also have contributed, and the search for these should be intensified...
- Prevalence of childhood celiac disease and changes in infant feedingAnneli Ivarsson
Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umea University, Umea, Sweden
Pediatrics 131:e687-94. 2013Between 1984 and 1996, Sweden experienced an "epidemic" of clinical celiac disease in children <2 years of age, attributed partly to changes in infant feeding...
- Pregnancy outcome and risk of celiac disease in offspring: a nationwide case-control studyKarl Mårild
Astrid Lindgren Children s Hospital, Solna, Sweden
Gastroenterology 142:39-45.e3. 2012Studies on pregnancy characteristics and mode of delivery and risk of later celiac disease in offspring are inconsistent...
- High fat consumption in children with celiac diseaseP Ferrara
Department of Pediatric Sciences, Universita Cattolica Sacro Cuore, Rome, Italy
Acta Gastroenterol Belg 72:296-300. 2009The purpose of this study was to estimate the caloric intake and fat consumption in children with celiac disease (CD) following a gluten-free diet (GFD).
- High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesionsRoberto Di Niro
Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
Nat Med 18:441-5. 2012b>Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous antigen gluten in individuals who express human leukocyte antigen HLA-DQ2 or ..
- Factors that influence adherence to a gluten-free diet in adults with celiac diseaseDaniel A Leffler
Department of Gastroenterology, The Celiac Center, Dana 501, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Dig Dis Sci 53:1573-81. 2008The only treatment for celiac disease is lifelong adherence to a gluten-free diet, yet adherence is limited and factors influencing adherence are poorly understood...
- The adaptive immune response in celiac diseaseShuo Wang Qiao
Department of Immunology and Centre for Immune Regulation, University of Oslo, Oslo University Hospital Rikshospitalet, 0027, Oslo, Norway
Semin Immunopathol 34:523-40. 2012..as type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, fundamental aspects of the pathogenesis in celiac disease are relatively well understood...
- A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challengeDaniel A Leffler
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Gastroenterol 107:1554-62. 2012In patients with celiac disease, enteropathy is caused by the entry of gluten peptides into the lamina propria of the intestine, in which their immunogenicity is potentiated by tissue transglutaminase (tTG) and T-helper type 1-mediated ..
- Celiac disease: antibody recognition against native and selectively deamidated gliadin peptidesM Aleanzi
Cátedra de Bioquímica Básica de Macromoléculas, INTEBIO, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Pje el Pozo CC 242, 3000 Santa Fe, Argentina
Clin Chem 47:2023-8. 2001..residues by tissue transglutaminase (tTG) turns gliadin peptides into stronger activators of T cells from celiac disease (CD) patients...
- Fracture risk in patients with celiac Disease, Crohn's disease, and ulcerative colitis: a nationwide follow-up study of 16,416 patients in DenmarkPeter Vestergaard
Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
Am J Epidemiol 156:1-10. 2002The authors studied fracture risk among 16,416 Danish patients with bowel disease. All patients diagnosed with celiac disease (n = 1,021), Crohn's disease (n = 7,072), or ulcerative colitis (n = 8,323) in Denmark between January 1, 1983, ..
- The incidence and risk of celiac disease in a healthy US adult populationMark S Riddle
Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
Am J Gastroenterol 107:1248-55. 2012b>Celiac disease (CD) is an increasingly common disease that may affect as many as 1% of the North American population. Recent population-based data suggest a substantial increase in the prevalence of CD over the last several decades...
- Risk of thyroid disease in individuals with celiac diseasePeter Elfström
Department of Pediatrics, Orebro University Hospital, SE 701 85 Orebro, Sweden
J Clin Endocrinol Metab 93:3915-21. 2008It has been suggested that celiac disease is associated with thyroid disease. Earlier studies, however, have been predominately cross-sectional and have often lacked controls. There is hence a need for further research...
- PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damageMaria Paola Simula
Experimental and Clinical Pharmacology Unit, CRO Centro diRiferimento Oncologico, IRCCS National Cancer Institute, Aviano PN, Italy
Mol Med 16:199-209. 2010b>Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of wheat gliadin and related proteins in genetically predisposed individuals...
- Influence of environmental and genetic factors linked to celiac disease risk on infant gut colonization by Bacteroides speciesEster Sanchez
Ecofisiología Microbiana y Nutrición, Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Avda Agustín Escardino 7, 46980 Paterna, Valencia, Spain
Appl Environ Microbiol 77:5316-23. 2011b>Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors whose interaction might influence disease risk...
- TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadinAinara Castellanos-Rubio
Endocrinology, Diabetes and Nutrition Research Group, Immunogenetics Laboratory, Hospital de Cruces, Bizkaia, Spain
Autoimmunity 42:69-73. 2009b>Celiac disease (CD) is an immunological disorder caused by intolerance to ingested gliadin and other cereal prolamins that has been included in the T(H)1-dominated group of diseases, where IL-12 induced IFNgamma is the major ..
- Unraveling the ties between celiac disease and intestinal microbiotaYolanda Sanz
Institute of Agrochemistry and Food Technology, Spanish National Research Council, Valencia, Spain
Int Rev Immunol 30:207-18. 2011b>Celiac disease is a multifactorial disorder that involves interactions between genetic and environmental factors...
- Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL studyGiada De Palma
Instituto de Agroquimica y Tecnologia de Alimentos, Consejo Superior de Investigaciones Científicas IATA CSIC, Valencia, Spain
PLoS ONE 7:e30791. 2012....
- Newly identified genetic risk variants for celiac disease related to the immune responseKaren A Hunt
Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
Nat Genet 40:395-402. 2008Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region...
- Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminaseIngrid Dahlbom
Department of Women s and Children s Health Paediatrics, Uppsala University, Uppsala, Sweden
J Pediatr Gastroenterol Nutr 50:140-6. 2010..We analysed whether the quantification of autoantibodies against tissue transglutaminase could be used to predict mucosal destruction and disease severity in patients with gluten sensitivity...
- Structural basis for gluten intolerance in celiac sprueLu Shan
Department of Chemical Engineering, Stanford University, Stanford, CA 94305 5025, USA
Science 297:2275-9. 2002..The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue...
- Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of diseaseJill M Norris
Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
JAMA 293:2343-51. 2005While gluten ingestion is responsible for the signs and symptoms of celiac disease, it is not known what factors are associated with initial appearance of the disease.
- Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawalAntonella Meloni
Pediatric Clinic II, Microcitemico Hospital ASL 8, Department of Biological Sciences and Biotechnology, University of Cagliari, Sardinia, Italy
J Pediatr 155:51-5, 55.e1. 2009To study the prevalence of autoimmune thyroiditis (AT) in Sardinian children with celiac disease (CD) and the effects of a gluten-free diet (GFD) on thyroid function.
- Celiac disease presenting as autismStephen J Genuis
University of Alberta, Alberta, Canada
J Child Neurol 25:114-9. 2010..After initial investigation suggested underlying celiac disease and varied nutrient deficiencies, a gluten-free diet was instituted along with dietary and supplemental ..
- Celiac disease: how complicated can it get?Jennifer May Ling Tjon
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, RC Leiden, The Netherlands
Immunogenetics 62:641-51. 2010In the small intestine of celiac disease patients, dietary wheat gluten and similar proteins in barley and rye trigger an inflammatory response...
- The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac diseaseAlessandra Pontillo
Medical Genetic Service, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
Am J Gastroenterol 106:539-44. 2011b>Celiac disease (CD) is a multifactorial common disorder with several susceptibility loci. Variations in the NALP1/NLRP1 and NALP3/NLRP3 genes have been reported to confer risk for several autoimmune conditions...
- Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac diseaseMaria Carmen Collado
Microbial Ecophysiology and Nutrition Group Institute of Agrochemistry and Food Technology, Spanish National Research Council CSIC, Burjassot, Valencia, Spain
BMC Microbiol 8:232. 2008..Samples (30 faecal samples and 8 biopsies) from a control age-matched group of children were also included for comparative purposes. Gut Bifidobacterium genus and species were analyzed by real-time PCR...
- Celiac diseaseAlberto Rubio-Tapia
Division of Gastroenterology and Hepatology, Departments of Medicine and Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Curr Opin Gastroenterol 26:116-22. 2010To summarize recent advances in celiac disease published between August 2008 and July 2009.
- Cutaneous manifestations in celiac diseaseL Abenavoli
Institute of Internal Medicine, Catholic University, L go Gemelli 8, 00168 Rome, Italy
World J Gastroenterol 12:843-52. 2006b>Celiac disease (CD) is an autoimmune gluten-dependent enteropathy characterized by atrophy of intestinal villi that improves after gluten-free diet (GFD)...
- Natural history of celiac disease autoimmunity in a USA cohort followed since 1974Carlo Catassi
Center for Celiac Research and Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
Ann Med 42:530-8. 2010The natural history and the possible changes of celiac disease (CD) prevalence over time are still unclear.
- Specific duodenal and faecal bacterial groups associated with paediatric coeliac diseaseM C Collado
Microbial Ecophysiology and Nutrition Group, Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Valencia, Spain
J Clin Pathol 62:264-9. 2009..To identify specific gut bacteria associated with coeliac disease (CD) at diagnosis and after treatment with a gluten-free diet (GFD) in a paediatric population...
- Current concepts of celiac disease pathogenesisD Schuppan
First Department of Medicine, University of Erlangen Nuernberg, Erlangen, Germany
Gastroenterology 119:234-42. 2000Our knowledge of celiac disease pathogenesis has recently made rapid progress...
- Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infectionAlexandra Zhernakova
Complex Genetics Section, Department of Medical Genetics, University Medical Centre Utrecht, P O Box 85060, 3508 AB Utrecht, The Netherlands
Am J Hum Genet 86:970-7. 2010b>Celiac disease (CD) is an intolerance to dietary proteins of wheat, barley, and rye. CD may have substantial morbidity, yet it is quite common with a prevalence of 1%-2% in Western populations...
- Current approaches to diagnosis and treatment of celiac disease: an evolving spectrumA Fasano
Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, Hospital for Children, Baltimore, Maryland 21201, USA
Gastroenterology 120:636-51. 2001b>Celiac disease (CD) is a syndrome characterized by damage of the small intestinal mucosa caused by the gliadin fraction of wheat gluten and similar alcohol-soluble proteins (prolamines) of barley and rye in genetically susceptible ..
- Genetic background of celiac disease and its clinical implicationsVictorien M Wolters
Department of Pediatric Gastroenterology, University Medical Center, Utrecht, The Netherlands
Am J Gastroenterol 103:190-5. 2008b>Celiac disease (CD) is a complex genetic disorder with multiple contributing genes. Linkage studies have identified several genomic regions that probably contain CD susceptibility genes...
- Diet improves perception of health and well-being in symptomatic, but not asymptomatic, patients with celiac diseaseAnniina Ukkola
Medical School, University of Tampere, Tampere, Finland
Clin Gastroenterol Hepatol 9:118-23. 2011The benefits of serologic screening and early diagnosis of celiac disease in asymptomatic patients are not known...
- Regulation of epithelial cell homeostasis by actin microfilamentsSeema Khurana; Fiscal Year: 2010..in bacterial, viral and parasitic infections, ischemia-reperfusion injury, inflammatory bowel disease, celiac disease and colorectal cancer...
- Irritable bowel syndrome-diarrhea: the role of gluten intolerance and HLA-DQ2MICHAEL L CAMILLERI; Fiscal Year: 2010..The relationship of celiac disease and IBS is complex;while guidelines suggest screening for celiac disease in patients with FD or IBS with ..
- Zot, Zonulin, and Pathophysiology of Intestinal Tight JunctionsAlessio Fasano; Fiscal Year: 2013..that zonulin expression is increased in autoimmune disorders associated with gut barrier dysfunction, such as celiac disease and type 1 diabetes...
- Celiac Disease: From Genetic Risk to Disease DevelopmentSusan L Neuhausen; Fiscal Year: 2009DESCRIPTION (provided by applicant): Celiac disease (CD, gluten-sensitive enteropathy, celiac sprue) is a common disease with significant morbidity if untreated...
- Non-Human Primate Model of Gluten-Sensitive EnteropathyKarol Sestak; Fiscal Year: 2013..In humans, gluten-sensitive enteropathy (GSE) is typically found in individuals genetically predisposed to celiac disease (CD), and in rhesus monkeys as well as in humans it can be induced by a gluten-containing diet...
- GAMMA DELTA T CELLS IN LYME ARTHRITISRalph C Budd; Fiscal Year: 2011..of inflammation in autoimmune syndromes such as in the synovial tissue in rheumatoid arthritis, the bowel in celiac disease, or the lungs in sarcoidosis. However, almost nothing is nothing regarding the specificity of ?? T cells...
- Development and Functional Analysis of Components of the Zebrafish Serotonin SignKenneth N Wallace; Fiscal Year: 2012..with digestive diseases including Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), and celiac disease. IBS is a common disorder with altered motility, secretion, and visceral sensation within the intestine for ..
- Benaroya Research Institute/UCDHSC Autoimmune Cooperative Study GroupGeorge S Eisenbarth; Fiscal Year: 2011..risk alleles (DR3/4-DQ8) and haplotype sharing with siblings, and defined related but unique risk factors for celiac disease. Faculty for the Cooperative Study Group has been recruited from the Departments of Immunology, Pediatrics, ..
- The immunobiology of CD4+ CD25+ T regulatory cellsThomas R Malek; Fiscal Year: 2013..variety of human autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and celiac disease. The IL-2Rb-deficient model used in some of these studies also has an important link to human autoimmunity...
- TILLING Wheat for Reduced Celiac Disease Causing ProteinsCHARLES PAUL MOEHS; Fiscal Year: 2010b>Celiac disease is an autoimmune digestive disorder in which intestinal lesions develop in genetically susceptible individuals in response to the ingestion of specific cereal seed storage proteins...
- Novel Mucosa-homing Dendritic Cell: Development, Trafficking and FunctionEugene C Butcher; Fiscal Year: 2013..g. for HIV or rotavirus) and to control pathologic inflammation (e.g. in inflammatory bowel diseases or celiac disease).
- Identification of Alopecia Areata Biomarkers in Skin and BloodAngela M Christiano; Fiscal Year: 2012..in AA unexpectedly revealed a number of risk loci shared by rheumatoid arthritis (RA), type 1 diabetes (T1D), celiac disease (CeD), SLE, MS and psoriasis (PS)...
- Molecular Mechanisms Linking HLA-DQ and AutoimmunityLuc Teyton; Fiscal Year: 2013DESCRIPTION (provided by applicant): Insulin-dependent diabetes mellitus (IDDM) and celiac disease are two of the most common immune-mediated diseases in humans...
- 16th International Congress of Mucosal Immunology (ICMI 2013)Joanne L Viney; Fiscal Year: 2013..cytokines, urogenital immunology, pulmonary immunology, inflammation, allergy, inflammatory bowel disease, celiac disease, lymphocyte homing, cytokines and chemokines, inflammation, mucosal antibodies, ocular and upper airway ..
- Small Molecules Targeting Allele Specific MHC Class II PresentationAaron W Michels; Fiscal Year: 2013..The human MHC class II molecules DQ8 and DQ2 are the major determinants of both type 1 diabetes and celiac disease with more than 99% of patients with celiac disease having DQ8 or DQ2 and more than 90% of patients with type 1 ..
- Effect of the PPAR Agonist Pioglitazone on Epidermal Barrier in Atopic DermatitisLISA ANN BECK; Fiscal Year: 2012..of other human diseases mediated in part by epithelial barrier defects including inflammatory bowel disease, celiac disease, sinusitis, food allergy and asthma...
- Genetic Architecture of Rheumatoid Arthritis in African-AmericansMARIA IOANA DANILA; Fiscal Year: 2013..and Asian populations through GWAS strategy in autoimmune diseases including RA, type 1 diabetes, lupus, celiac disease, autoimmune thyroid disease, inflammatory bowel disease, ankylosing spondylitis, psoriasis and other diseases...
- 3'alpha enhancer regulation by AhR and NF-kappaB/Rel proteinsCOURTNEY ELIZABETH WILLIAMS SULENTIC; Fiscal Year: 2011..also been associated with specific human pathologies including Burkitt's lymphoma, IgA nephropathy and Celiac disease. Many of the toxic effects of TCDD and related chemicals have been attributed to changes in gene expression ..
- Gastro-intestinal microbes degrading dietary glutenEVA JOSEPHINE HELMERHORST; Fiscal Year: 2013..Glutens elicit immunologic reactions and serious clinical conditions in patients suffering from celiac disease. The basis of this disease is an auto-immune disorder in which a host-anti-self response is triggered by ..
- Reduced gluten cereal grainsCHARLES PAUL MOEHS; Fiscal Year: 2013DESCRIPTION (provided by applicant): Celiac disease (CD) is the most common food sensitive enteropathy known, affecting approximately 1% of the population and its incidence appears to be on the rise...
- Web-based and Interactive Virtual Environments for Children with Food AllergiesJosh S Spitalnick; Fiscal Year: 2013..for children with other chronic conditions requiring self-management, such as asthma, diabetes, and celiac disease. The promise of commercial opportunity is significant in an era in which there is an increasingly widespread ..
- Role of transglutaminase 2 in celiac sprueChaitan Khosla; Fiscal Year: 2013DESCRIPTION (provided by applicant): Our broad goal is to understand the role of transglutaminase 2 (TG2) in celiac disease pathogenesis...
- Innate and adaptive immunity in celiac diseaseBana Jabri; Fiscal Year: 2013DESCRIPTION (provided by applicant): Celiac disease is a complex intestinal inflammatory disorder with villous atrophy induced by dietary gluten in HLA-DQ2 or HLA-DQ8 individuals...
- Validation of Novel Peptide/Protein Markers for Diagnosis of Type 1 DiabetesQibin Zhang; Fiscal Year: 2012..of T1D;Aim 2, to establish the specificity of marker peptides using disease controls of type 2 diabetes, celiac disease and inflammatory bowel disease;Aim 3, to identify the protein isoforms of key marker peptides having potential ..
- A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONDECLAN MCCOLE; Fiscal Year: 2013..a crucial role in a number of chronic intestinal inflammatory conditions including Type 1 Diabetes (T1D), celiac disease, as well as Crohn's disease (CD) and ulcerative colitis (UC), collectively referred to as inflammatory ..
- The Environmental Triggers of Diabetes (TEDDY)Ake Lernmark; Fiscal Year: 2013..exposures that may trigger or protect against the development of islet autoimmunity and T1D as well as celiac disease, a common co-morbidity to T1D...
- Analysis of TLR4-dependent Innate Immune Responses induced by Dietary GlutensKRISTINA MICHELLE HARRIS; Fiscal Year: 2012DESCRIPTION (provided by applicant): The quality of life for over 2 million Americans with celiac disease (CD) is significantly compromised because the only treatment is strict compliance to a gluten-free diet...
- gd IEL migration and epithelial interactions in intestinal diseaseKAREN LEIGH EDELBLUM; Fiscal Year: 2013..to identify epithelial/immune cell interactions and determine the relevance of these interactions to IBD and celiac disease. The proposed research and career development plan, along with my mentors, advisory committee and the ..
- Oral microbial enzymes for the treatment of celiac diseaseEVA JOSEPHINE HELMERHORST; Fiscal Year: 2013..The applicant's studies are focusing on a novel domain of gastro-intestinal enzymology related to celiac disease. Celiac disease is an auto-immune disorder in which a host anti-self response is triggered by gluten-derived ..
- Otubain 1 as a novel regulator of IL-15 signaling in CD8+ T cellsALBERT CHUH KAI LEE; Fiscal Year: 2013..implicated in the pathogenesis of the intestinal inflammatory diseases, inflammatory bowel disease (IBD) and celiac disease. IL- 15 levels are elevated in both diseases and can correlate with disease severity in celiac disease...
- Regulation of osteoblast maturation by transglutaminasesMaria Nurminskaya; Fiscal Year: 2010..Further, the presence of circulating autoantibodies against TG2 in diabetes and celiac disease correlates with short stature and osteopenia, implicating involvement of transglutaminases in both bone ..
- Non-invasive markers of celiac disease activity during gluten challengeDANIEL ALEXANDER LEFFLER; Fiscal Year: 2013..Drs. Ciaran P. Kelly and Detlef Schuppan, both acknowledged experts in celiac disease, will serve as mentors. A mentoring committee including Drs...
- Mechanisms and pathways of trans-tight junction conductanceChristopher Weber; Fiscal Year: 2013..and dysfunction, which may provide better therapeutic approaches for intestinal disorders such as IBD, celiac disease, and infectious colitis...
- Characterization of Innate immune receptorsDetlef Schuppan; Fiscal Year: 2009b>Celiac disease (Cd) is a T cell mediated disease of the small intestine. It is triggered by dietary gluten proteins from cereals and affects 1 in 130 US citizens...
- Microbial Regulation of Macromolecule Absorption in the Zebrafish IntestineJordan L Cocchiaro; Fiscal Year: 2012..transcellular macromolecule transport ("ETMT") is associated with inflammatory bowel diseases (IBD), celiac disease, and food allergies...
- Genetic and Environmental Causes of Celiac Disease.Marian J Rewers; Fiscal Year: 2013DESCRIPTION (provided by applicant): Celiac disease (CD) is a major public health problem affecting at least 1% of the general population and leading to significant morbidity and mortality...
- Validation of Peripheral Microparticles as Novel Biomarkers of Celiac Disease ActDANIEL ALEXANDER LEFFLER; Fiscal Year: 2013DESCRIPTION (provided by applicant): Celiac disease is a T cell mediated immune disorder triggered by dietary gluten intake that affects approximately 1% of the US population and has significant deleterious effects on health and ..
- Characterizing the genetic architecture of childhood onset celiac disease using nEdwin Liu; Fiscal Year: 2010b>Celiac disease (CD) is a major public health problem affecting up to 1% of the general population and leading to significant morbidity and mortality...
- MONONUCLEAR PHAGOCYTE FUNCTION IN IMMUNOLOGIC DISEASESRobert P Kimberly; Fiscal Year: 2010..for the gamma-chain associated receptors, to determine their functional characteristics and to establish their association with altered host defense and autoimmune disease (eg, rheumatoid arthritis, celiac disease, systemic vasculitis).
- STRUCTURAL STUDY OF HLA-DQ2 AND AN ASSOCIATED COMPLEXIrimpan I Mathews; Fiscal Year: 2011..One of the diseases with the strongest association with particular MHC alleles is celiac disease, for which there is also mechanistic insight into the basis for the human leukocyte antigen (HLA) association...
- Function of Myosin-X in Intestinal Apical Domain AssemblyKATY LIU; Fiscal Year: 2013..of the apical domain alters its selective barrier function: malabsorption by microvilli is evident in celiac disease and microvillous inclusion disease, and disruption of the apical junction barrier contributes to the ..
- Themis Regulation of Thymocyte SelectionNICHOLAS R GASCOIGNE; Fiscal Year: 2011..to be of importance to medicine as a single nucleotide polymorphism in THEMIS is strongly associated with celiac disease. Themis appears to act by altering the sensitivity of the T cell receptor to ligands that would normally be at ..
- The TEDDY study: Georgia/Florida clinical centerJin Xiong She; Fiscal Year: 2013..1) Follow the TEDDY cohort of 8677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years;2) Collect all planned biological specimens and epidemiological data according to the ..
- GENETIC ANALYSIS OF ALTERED IMMUNITY IN CELIAC DISEASEJOSEPH MICHALSKI; Fiscal Year: 1990b>Celiac disease (or gluten sensitive enteropathy) is a debilitating gastrointestinal disorder in which an aberrant immune response to dietary gluten results in destruction of the jejunal mucosa...
- The Environmental Determinants of Diabetes in the Young (TEDDY) Colorado ClinicalMarian J Rewers; Fiscal Year: 2013..1) Follow the TEDDY cohort of 8677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years;2) Collect all planned biological specimens and epidemiological data according to the ..
- The Environmental Determinants of Diabetes in Youth: Washington Clinical CenterWilliam A Hagopian; Fiscal Year: 2013..1) Follow the TEDDY cohort of 8,677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years;2) Collect all planned biological specimens and epidemiological data according to the ..
- Antibody Reprtoire Characterization in Celiac DiseasePatrick S Daugherty; Fiscal Year: 2013..antibody repertoire profiling microarrays for diagnosis, prognostication, and therapeutic monitoring of Celiac Disease. Using high-resolution antibody specificity data, novel self- and non-self antigens will be identified as the ..
- INVESTIGATION Of HUMAN COMPLEMENTCHESTER ALPER; Fiscal Year: 1999..Finally, we plan to try to explain the evolution and genetic mechanisms of origin of haplotypes with the relatively rare variant of the second component of complement, C2 B. ..
- GENETIC ANALYSIS OF NORMAL AND MALIGNANT LYMPHOCYTESEdmond Yunis; Fiscal Year: 1991..These studies will identify the possible involvement of negative regulatory sequences and transacting repressor mechanisms in the stable repression of Class II genes during myelomonocytic cell differentiation...
- Limited Competition for the Continuation of Clinical Centers for the EnvironmentANETTE ZIEGLER; Fiscal Year: 2013..1) Follow the TEDDY cohort of 8677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years;2) Collect all planned biological specimens and epidemiological data according to the ..
- DERMATITIS HERPETIFORMIS AND THE MUCOSAL IMMUNE RESPONSERussell Hall; Fiscal Year: 2005..These studies will provide insights into the pathogenesis of DH and isolated GSE, the relationship between the MIR and the skin and factors important in controlling the mucosal immune response in man. ..
- CELIAC DISEASE IN OSTEOPOROSISWILLIAM STENSON; Fiscal Year: 2004DESCRIPTION (Abstract of the application) There is compelling evidence that the prevalence of celiac disease in the general population in the United States is higher than is generally appreciated and that patients with the symptoms ..
- DERMATITIS HERPETIFORMIS & THE MUCOSAL IMMUNE RESPONSERussell Hall; Fiscal Year: 1992..These studies will provide insights into the pathophysiology of DH, the relationship of the serum and secretory IgA responses to mucosal antigen exposure and the role of HLA associations in autoimmune disease...
- Are IL-18 receptor-bearing CD8 T cells pathogenic in human Type 1 diabetes?NORA E SARVETNICK; Fiscal Year: 2011..Second, IL-18 is a risk factor for other autoimmune diseases such as celiac disease. Third, evaluation of the IL-18 binding protein for its use in clinical trials has been performed, and the ..
- Timing of Gluten Intake In Infant Nutrition and Risk of Celiac Disease AutoimmuniAlessio Fasano; Fiscal Year: 2009DESCRIPTION (provided by applicant): Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten containing grains (i.e.;wheat, barley, and rye) in genetically susceptible individuals...
- MODELS IN POPULATION GENETICSGlenys Thomson; Fiscal Year: 2000..diabetes mellitus, rheumatoid arthritis, multiple sclerosis, ankylosing spondylitis, hemochromatosis, celiac disease, and others...
- MOLECULAR AND BIOCHEMICAL ANALYSIS OF THE CANINE MHCJohn Wagner; Fiscal Year: 2001..Class II expression will be initially studied using existing cross-reactive MAbs. ..
- Development of a LH-PCR Based Diagnostic for Inflammatory Bowel DiseasePatrick Gillevet; Fiscal Year: 2007..disease not limited to IBD but also in other areas such as colorectal carcinogenesis, intestinal infections, celiac disease, irritable bowel syndrome, prebiotic and probiotic therapies...
- 14th International Congress of Mucosal ImmunologyRichard Blumberg; Fiscal Year: 2009..cytokines, urogenital immunology, pulmonary immunology, inflammation, allergy, inflammatory bowel disease, celiac disease, lymphocyte homing, cytokines and chemokines, inflammation, mucosal antibodies, ocular and upper airway ..
- Gluten Sensitivity in the Old Order AmishDaniel McBride; Fiscal Year: 2005Gluten-sensitive enteropathy (GSE; VIM 607202) or celiac disease (CD; MIM 212750) has been well recognized as a public health concern for some time in Europe...
- MicroRNAs in Giardia PathogenesisSteven M Singer; Fiscal Year: 2010..This information will provide new strategies for treating common diseases like celiac disease and inflammatory bowel disease as well as diarrheal diseases like Giardia.
- ASSESSING MUCOSAL SURFACE AREA IN CELIAC DISEASEMorteza Janghorbani; Fiscal Year: 2000..a noninvasive method for quantitative assessment of the extent of intestinal mucosal surface area involved in celiac disease. The proposed approach is based on the hypothesis that under certain experimental conditions changes in ..
- HLA-DQ-derived RTLs for Treatment of Celiac DiseaseGREGORY BURROWS; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Celiac disease is an inflammatory autoimmune disease in which CD4+ T cells target, damage and eventually destroy the villous tissue structures of the small intestine, interfering with the ..
- A Test of Iron Malabsorption in Patients with IDAMorteza Janghorbani; Fiscal Year: 2005..g celiac disease, H. pylori gastritis, or IDA patients refractory to iron supplementation, etc...