Genomes and Genes
viral cell transformation
Summary: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Publications209 found, 100 shown here
- cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cellsA C Vertegaal
Laboratory for Molecular Carcinogenesis, MGC Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
FEBS Lett 487:151-5. 2000..This cellular gene was found to be the gene encoding follistatin-related protein, a TGF-beta inducible gene. Consistently, a constitutive factor binding to Smad binding elements was found in adenovirus type 12-transformed cells...
- EBV Immortalization of human B lymphocytes separated from small volumes of cryo-preserved whole bloodM M Amoli
Centre for Integrated Genomic Medical Research, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Int J Epidemiol 37:i41-5. 2008..5 ml cryo-preserved whole blood samples. These were EBV transformed in microtitre plates and subsequently expanded in culture. A pilot study within UK Biobank was performed, which confirmed its potential usefulness for this study...
- Loss of robustness and addiction to IGF1 during early keratinocyte transformation by human Papilloma virus 16Tamar Geiger
Unit of Cellular Signaling, Department of Biological Chemistry, Alexander Silverman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
PLoS ONE 2:e605. 2007..We conclude that transformation in this model induces higher susceptibility of cells to stress due to reduced anti-apoptotic signaling and hyper-activation of p53 upon stress...
- [Establishment of immortalized B-lymphoblastoid cell lines of keloid pedigree and its karyotype analysis]Mei Song
Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Nan Fang Yi Ke Da Xue Xue Bao 26:1760-2. 2006..To establish immortalized B-lymphoblastoid cell lines of keloid pedigree transformed with Epstein-Barr (EB) virus and conduct karyotype analysis of the cells...
- HTLV-1 Tax and adult T-cell leukemiaChou Zen Giam
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Front Biosci 12:1496-507. 2007....
- Association of human papillomavirus types 16 and 18 E6 proteins with p53B A Werness
Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892
Science 248:76-9. 1990....
- Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodelingChristopher W Dawson
Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
J Biol Chem 278:3694-704. 2003....
- Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteinsShan Lu Liu
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Virol 77:2850-8. 2003....
- The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single natureSalvador Harguindey
Centro Médico La Salud, Independencia, 13 01004 Vitoria, Spain
Biochim Biophys Acta 1756:1-24. 2005....
- Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instabilityStefan Duensing
Department of Pathology, Harvard Medical School, Armenise Research Building, D2 537, 200 Longwood Avenue, Boston, Massachusetts, MA 02115, USA
Oncogene 21:6241-8. 2002..These findings suggest that HPV oncoprotein-induced chromosomal instability increases the risk for genetic changes that may ultimately facilitate carcinogenic progression...
- Transformation of normal human cells in the absence of telomerase activationYvette R Seger
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Cancer Cell 2:401-13. 2002..Notably, transformation did not require telomerase activation. Therefore, we provide evidence that activation of telomere maintenance strategies is not an obligate characteristic of tumorigenic human cells...
- Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell linesJason S Knight
Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia 19104, USA
J Virol 77:4261-72. 2003..Clearly, EBNA3C functions as a component of a number of dynamic complexes which function in repression and activation of transcription...
- Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirusAlla Danilkovitch-Miagkova
Laboratory of Immunobiology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 100:4580-5. 2003..We find activated RON in a subset of human bronchioloalveolar carcinoma tumors, suggesting RON involvement in this type of human lung cancer...
- microRNAs in viral oncogenesisVinod Scaria
Retrovirology 4:82. 2007..The host-virus crosstalk mediated by microRNAs, messenger RNAs and proteins, is complex and involves the different cellular regulatory layers. In this commentary, we describe models of microRNA mediated viral oncogenesis...
- E2F: a link between the Rb tumor suppressor protein and viral oncoproteinsJ R Nevins
Howard Hughes Medical Institute, Section of Genetics, Duke University Medical Center, Durham, NC 27710
Science 258:424-9. 1992....
- Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinomaHui Zheng
Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Cell Mol Immunol 4:185-96. 2007..Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC...
- Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetaseLaurent Lefebvre
Faculty of Agronomy, Gembloux, Belgium
J Virol 76:1400-14. 2002..Identification of FPPS as a molecular partner for p13(II) and G4 accessory proteins opens new prospects for treatment of retrovirus-induced leukemia...
- Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformationS K Rai
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 98:4443-8. 2001..The finding that JSRV env is oncogenic and the identification of HYAL2 as the JSRV receptor provide tools for further investigation of the mechanism of JSRV oncogenesis and its relationship to human bronchiolo-alveolar carcinoma...
- Activation of the anaphase promoting complex by HTLV-1 tax leads to senescenceYu Liang Kuo
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
EMBO J 25:1741-52. 2006..Finally, activation of APC ahead of schedule may be exploited to arrest cancer cell growth...
- Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformationMasao Matsuoka
Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Japan
Nat Rev Cancer 7:270-80. 2007..We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia...
- Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformationMichael D Lairmore
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210 1093, USA
Oncogene 24:6005-15. 2005..Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma...
- PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell lineAkira Hirata
Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
Virology 318:327-36. 2004....
- Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1Hyeon Ung Park
Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Oncogene 23:4966-74. 2004..The G(2) arrest did not require Chk2 or p53. These studies provide the first example of a viral transforming protein targeting Chk1 and provide important insights into checkpoint pathway regulation...
- Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replicationBlanca Lupiani
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
Proc Natl Acad Sci U S A 101:11815-20. 2004..A revertant virus that restored the expression of the meq gene, showed properties similar to those of the parental virus, confirming that Meq is involved in transformation but not in lytic replication in chickens...
- Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell lineMasaya Higuchi
Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
J Virol 81:11900-7. 2007....
- Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferationJoshua Arnold
Center for Retrovirus Research, Department of Veterinary Biosciences and Molecular Virology Immunology, The Ohio State University, Columbus, OH 43210, USA
Blood 112:3788-97. 2008..Our data indicate that Hbz expression enhances the proliferative capacity of HTLV-1-infected T cells, playing a critical role in cell survival and ultimately HTLV-1 tumorigenesis in the infected host...
- Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cellsKathryn S Jones
Basic Research Program, Science Applications International Corporation Frederick, Frederick, Maryland 21702, USA
Nat Med 14:429-36. 2008..In addition to altering the current paradigm concerning how HTLV-1 transmission occurs, these studies suggest that impairment of DC function after HTLV-1 infection plays a part in pathogenesis...
- Recombinant Marek's disease virus (MDV)-derived lymphoblastoid cell lines: regulation of a marker gene within the context of the MDV genomeM S Parcells
Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
J Virol 73:1362-73. 1999..Our results indicate that regulation of the lacZ marker gene can serve as sensitive measure of virus lytic-phase induction and the reactivation from latency...
- Centrosome and retroviruses: the dangerous liaisonsPhilippe V Afonso
Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Departement de Virologie, Institut Pasteur, Paris, France
Retrovirology 4:27. 2007..Enthrallingly, HTLV-1 Tax expression also targets the functions of the centrosome, and this event is correlated with centrosome amplification, aneuploidy and transformation...
- Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 TaxKeiichi Endo
Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
J Virol 76:2648-53. 2002..Our results showed that Tax2 has a lower transforming activity than Tax1 and suggest that the high transforming activity of Tax1 is involved in the leukemogenic property of HTLV-1...
- Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life styleJ L Liu
Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
Virus Genes 21:51-64. 2000..In this review, we will attempt to summarize the past research progress on MDV meq, with a focused on the similarities and differences between MEQ and cellular proteins, and between MEQ and other viral oncoproteins...
- GITR overexpression on CD4+CD25+ HTLV-1 transformed cells: detection by massively parallel signature sequencingHarshawardhan P Bal
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
Biochem Biophys Res Commun 332:569-84. 2005....
- Epstein-Barr virus with the latent infection nuclear antigen 3B completely deleted is still competent for B-cell growth transformation in vitroAdrienne Chen
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Virol 79:4506-9. 2005..Deletion of the entire EBNA-3B open reading frame from the EBV BAC had no adverse impact on growth of EBV-immortalized B cells, providing formal proof that EBNA-3B is not essential for EBV-mediated B-cell growth transformation in vitro...
- Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virusMasanobu Sugimoto
GeneCare Research Institute, Kanagawa, Japan
Cancer Res 64:3361-4. 2004..The new concept as reviewed here is essential for the future study of tumorigenesis by EBV...
- Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoproteinJean Marie Peloponese
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Biol Chem 281:8927-38. 2006..Tax is shown to activate activator protein-1 through the phosphatidylinositol 3-kinase/Akt pathway...
- Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virusAndrew C Brown
Viral Oncogenesis Group, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
Proc Natl Acad Sci U S A 103:1687-92. 2006..Engineering MDV with precisely defined attenuating mutations, therefore, represents an effective strategy for generating new vaccines against this major poultry disease...
- HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitroJianxin Ye
The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
Blood 102:3963-9. 2003..However, Rex is critical for efficient infection of cells and persistence in vivo...
- Differential cytotoxicity of anticancer agents in pre- and post-immortal lymphoblastoid cell linesKaori Sawada
GeneCare Research Institute, Kanagawa, Japan
Biol Pharm Bull 28:1202-7. 2005..Based on these results, we propose that pre-N0005 and post-N0005 cell lines be used as a new method to assess and screen anticancer agents...
- Methylation status of the Epstein-Barr virus (EBV) BamHI W latent cycle promoter and promoter activity: analysis with novel EBV-positive Burkitt and lymphoblastoid cell linesIsabel A Hutchings
Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Virol 80:10700-11. 2006..Thus, studies of B cells with atypical patterns of Wp usage emphasize the strong correlation between the presence of unmethylated Wp sequences and promoter activity...
- Accelerated G(1) phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoproteinF J Lemoine
Interdepartmental Program of Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 276:31851-7. 2001..Tax-associated acceleration of cell cycle progression may play a role in the ability of this viral oncoprotein to mediate cellular transformation and promote the development of human T cell leukemia virus type I-associated diseases...
- A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesisSascha Trapp
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
J Exp Med 203:1307-17. 2006..We concluded that vTR plays a critical role in MDV-induced T cell lymphomagenesis. Furthermore, our results provide the first description of tumor-promoting effects of TR in a natural virus-host infection model...
- Oncogenic gamma-herpesviruses: comparison of viral proteins involved in tumorigenesisBlossom Damania
Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Nat Rev Microbiol 2:656-68. 2004
- Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cellsHongyi Pan
Tumor Virology Program, Children Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, 78229, USA
Cancer Res 64:4064-8. 2004..Our results indicate that KSHV infection could predispose cells to malignant transformation through induction of genomic instability and contributes to the development of KS...
- NFkappaB signaling is induced by the oncoprotein Tio through direct interaction with TRAF6Stefanie Heinemann
Institut fur Klinische und Molekulare Virologie, Friedrich Alexander Universitat Erlangen Nurnberg, Schlossgarten 4, 91054 Erlangen, Germany
J Biol Chem 281:8565-72. 2006..Furthermore, we provide evidence that TRAF6 directly binds to the Tio oncoprotein. Identification of TRAF6 as the direct target of Tio describes a novel mechanism for the constitutive activation of NFkappaB through an oncoprotein...
- Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax proteinKojiro Ishioka
Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
Retrovirology 3:71. 2006..The interaction of human T-cell leukemia virus type 1 (HTLV-1) Tax1 protein with the tumor suppressor Dlg1 is correlated with cellular transformation...
- Proliferation and differentiation in isogenic populations of peripheral B cells activated by Epstein-Barr virus or T cell-derived mitogensJenny O'Nions
Department of Virology and Ludwig Institute for Cancer Research, Wright Fleming Institute, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK
J Gen Virol 85:881-95. 2004..The study has also identified a window of opportunity during which a comparison of isogenic populations of EBV- and mitogen-driven B blasts can be made...
- Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3Minako Ohashi
Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
Virology 320:52-62. 2004..Our results suggest that the interaction of Tax1 and MAGI-3 alters their respective biological activities, which may play a role in transformation by Tax1 as well as in the pathogenesis of HTLV-1-associated diseases...
- Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesisRenee M Overmeer
Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
J Pathol 219:327-36. 2009..Hence, MAL promoter methylation and/or mRNA expression analysis on cervical scrapings may provide a valuable diagnostic tool to improve the detection of CIN3, SCC, and AdCA...
- B cells under influence: transformation of B cells by Epstein-Barr virusRalf Kuppers
Institute for Genetics, Department of Internal Medicine I, University of Cologne, 50931 Cologne, Germany
Nat Rev Immunol 3:801-12. 2003....
- Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cellsTakayuki Nitta
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
Cancer Sci 97:836-41. 2006..These findings suggest that Tax deregulates CDK activity and induces centrosome amplification, which might be associated with cellular transformation by HTLV-1 and chromosomal instability in HTLV-1-infected human T cells...
- Signal transduction pathways utilized by enzootic nasal tumor virus (ENTV-1) envelope protein in transformation of rat epithelial cells resemble those used by jaagsiekte sheep retrovirusNaoyoshi Maeda
Cancer Research Institute, University of California, Irvine, Sprague Hall, Irvine, CA 92697 3900, USA
Virus Genes 36:147-55. 2008..These results indicate that the signaling pathways for ENTV and JSRV transformation are quite similar, consistent with the notion that these proteins do not determine the tissue-specificity of the tumors for these viruses...
- PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivoLi Xie
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
Blood 107:1980-8. 2006....
- In vivo tumorigenesis by Jaagsiekte sheep retrovirus (JSRV) requires Y590 in Env TM, but not full-length orfX open reading frameChris Cousens
Moredun Research Institute, Pentlands Science Park, Penicuik, Edinburgh, UK
Virology 367:413-21. 2007..In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV(21)...
- Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2A Dusty Miller
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
BMC Cancer 4:64. 2004..When Env was expressed it bound to Hyal2 causing its degradation, release of RON activity from Hyal2 suppression, and activation of pathways resulting in cell transformation...
- Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cellsJ F Charlot
Universite de Franche Comte, UFR Médecine et Pharmacie, EA 3181, IFR 133 19 rue Ambroise Paré, 25000 Besancon, France
Apoptosis 11:813-27. 2006..Moreover, Pifithrin-alpha could be used in combination with ST and PRIMA-1 to prevent side effects of anti-tumor therapies in cells expressing mutant P53...
- HBZ, a new important player in the mystery of adult T-cell leukemiaJean Michel Mesnard
Laboratoire Infections Retrovirales et Signalisation Cellulaire, Centre National de la Recherche Scientifique CNRS Unité mixte de recherche UMR 5121 UM1, Montpellier, France
Blood 108:3979-82. 2006..One report suggests that the HBZ gene might have a bimodal function (at the mRNA and protein levels), which could represent an uncharacterized strategy to regulate viral replication and proliferation of infected T cells...
- In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcomaAgata D Agostino Mutlu
Laboratory of Viral Oncogenesis, Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
Cancer Cell 11:245-58. 2007..These results show that KSHV malignancy is in vivo growth restricted and reversible, defining mECK36 as a biologically sensitive animal model of KSHV-dependent KS...
- CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell linesH M Long
CRUK Institute for Cancer Studies, The University of Birmingham, Vincent Dr, Edgbaston, Birmingham B15 2TT, United Kingdom
J Virol 79:4896-907. 2005..Thus, while CD4+ T-cell responses are detectable against many epitopes in EBV latent proteins, only a minority of these responses are likely to have therapeutic potential as effectors directly recognizing latently infected target cells...
- Copy number increase of 1p36.33 and mitochondrial genome amplification in Epstein-Barr virus-transformed lymphoblastoid cell linesJae Pil Jeon
Biobank for Health Sciences, Center for Genome Science, National Institute of Health, Korea Center for Disease Control and Prevention, 5 Nokbun, Eunpyung Gu, Seoul 122 701, Republic of Korea
Cancer Genet Cytogenet 173:122-30. 2007..33 due to increased mitochondrial DNA copy numbers. Thus, analyses of array CGH profiles of diseases should take into account the potential for copy number variation of 1p36.33...
- Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell linesNaoyoshi Maeda
Cancer Research Institute, University of California, Irvine, Irvine, CA 92697 3900, USA
J Virol 79:4440-50. 2005....
- Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancyVincent Moules
Oncovirologie et Biothérapies, UMR5537 CNRS Université Claude Bernard, Centre Leon Berard, Lyon, France
Cancer Res 65:1234-43. 2005..5 to 60 months of clinical latency, when a dramatic decrease in the genetic instability of premalignant cells coincided with a rapid increase in lymphocyte count and lymphoma onset...
- A methylation profile of in vitro immortalized human cell linesLimin Liu
Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
Int J Oncol 26:275-85. 2005..In general, more genes were methylated in neoplastically-transformed cell lines than in only immortalized cell lines, indicating that accumulation of epigenetic abnormalities may contribute to oncogenesis...
- Multiple domains of the Jaagsiekte sheep retrovirus envelope protein are required for transformation of rodent fibroblastsAndrew Hofacre
Cancer Research Institute, Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697 3905, USA
J Virol 78:10479-89. 2004..The resulting transformants showed evidence for the presence and expression of both mutant plasmids...
- Oncogenesis by retroviruses: old and new paradigmsNaoyoshi Maeda
Division of Host Defense, Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
Rev Med Virol 18:387-405. 2008..In this review, we will summarise research on retrovirus oncogenic transformation over the past 100 years since the first published report of an oncogenic virus with particular attention to Env-induced transformation...
- Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require phosphatidylinositol 3-kinaseNaoyoshi Maeda
Cancer Research Institute, University of California Irvine, Irvine, CA 92697 3000, USA
J Virol 77:9951-9. 2003..Therefore, JSRV envelope can induce PI3K-independent phosphorylation of Akt...
- A phosphatidylinositol 3-kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced transformation of NIH 3T3 cellsM Palmarini
Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, 30602, USA
J Virol 75:11002-9. 2001....
- Kinetic and phenotypic changes in murine lymphocytes infected with murine gammaherpesvirus-68 in vitroB M Dutia
Department of Veterinary Pathology, University of Edinburgh, Summerhall, UK
J Gen Virol 80:2729-36. 1999..This DNA was nuclease sensitive, indicating that, while MHV-68 was efficiently uncoated, its circularization in vitro was extremely inefficient. These results are discussed in terms of the host-virus interaction...
- Human T-cell leukemia virus type 1 tax protein activates transcription through AP-1 site by inducing DNA binding activity in T cellsK Iwai
Department of Virology, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan
Virology 279:38-46. 2001..Our results suggest that Tax activates the transcription of cellular genes with AP-1 sites by inducing the DNA-binding activity of AP-1 proteins in T cells, a mechanism distinct from those of CRE-like and kappaB elements...
- Multiple viral strategies of HTLV-1 for dysregulation of cell growth controlM Yoshida
Banyu Tsukuba Research Institute, Tsukuba, Ibaraki 300 2611, Japan
Annu Rev Immunol 19:475-96. 2001..This is an effective viral strategy to amplify its proviral genome through replication of infected cells; ultimately it results in cell transformation and leukemogenesis...
- Envelope-induced cell transformation by ovine betaretrovirusesAlberto Alberti
Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
J Virol 76:5387-94. 2002..In addition, phosphorylated Akt was detected in a cell line derived from a lung tumor of a sheep with naturally occurring ovine pulmonary adenocarcinoma...
- Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNAN Maeda
Cancer Research Institute and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 98:4449-54. 2001..These results indicate that the envelope gene carries the transforming potential. This is an unusual example of a native retroviral structural protein with transformation potential...
- Interferon--gamma control of EBV-transformed B cells: a role for CD8+ T cells that poorly kill EBV-infected cellsYan Shi
Department of Pathology, University of Iowa, Iowa City 52242 1182, USA
Viral Immunol 15:213-25. 2002..Inhibitory factor activity was neutralized by anti-IFN-gamma monoclonal antibodies (mAb), but not by antibodies to several other cytokines. These data suggest an in vivo role for IFN-y secreting EBV-specific CD8+ T cells...
- LMP1 structure and signal transductionA G Eliopoulos
CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham, B15 2TA, UK
Semin Cancer Biol 11:435-44. 2001..The constitutive engagement of these signals and the characteristic molecular interactions that regulate them provide the basis for the molecular explanation of the transforming properties of this key EBV protein...
- Mechanism of cell entry and transformation by enzootic nasal tumor virusClarissa Dirks
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
J Virol 76:2141-9. 2002..The transcriptional regulatory elements in these viruses are quite different, indicating that tissue-specific oncogenesis is likely regulated at the level of viral gene expression...
- The ubiquitin/proteasome system in Epstein-Barr virus latency and associated malignanciesNico P Dantuma
Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 17177 Stockholm, Sweden
Semin Cancer Biol 13:69-76. 2003..Knowledge of these multiple strategies of interference with regulated proteolysis may provide new clues for the treatment of EBV-associated malignancies...
- Telomerase activity in high-grade cervical lesions is associated with allelic imbalance at 6Q14-22Mark van Duin
Department of Pathology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Int J Cancer 105:577-82. 2003..These data suggest that 6q14-22 may contain 1 or more genes involved in telomerase deregulation and immortalization during cervical carcinogenesis...
- Evidence for a putative senescence gene locus within the chromosomal region 10p14-p15M Poignee
Gynäkologische Molekularbiologie, Abteilung Frauenheilkunde, Frauenklinik der Friedrich Schiller Universität Jena, 07743 Jena, Germany
Cancer Res 61:7118-21. 2001..The potential significance of loss of gene function in this region is underlined by the high frequency (38.7%) of loss of heterozygosity in cervical cancers including early stage tumors...
- Transformation of rodent fibroblasts by the jaagsiekte sheep retrovirus envelope is receptor independent and does not require the surface domainYen Hung J Chow
Department of Medical Microbiology and Parasitology and Comparative Oncology Program, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
J Virol 77:6341-50. 2003..Taken together these results indicate that the interaction with Hyal-2 at least is not an essential determinant of JSRV-induced transformation of fibroblasts and that the viral TM functions essentially as an oncoprotein...
- Putative phosphatidylinositol 3-kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt activationShan Lu Liu
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Virol 77:7924-35. 2003..We conclude that ovine betaretrovirus Env proteins transform the rodent fibroblasts by indirectly activating the PI3K/Akt pathway...
- EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cellsElena Kashuba
Microbiology and Tumor Biology Center MTC, Karolinska Institute, Nobels vag 16, Box 280, S 171 77 Stockholm, Sweden
Int J Cancer 105:644-53. 2003..The inclusions also contained p53 and HDM2, and were surrounded by PML bodies and proteasomes, which suggests that these inclusions could be targets for proteasome dependent protein degradation...
- Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirusGuillermo Zavala
Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
Virology 312:95-105. 2003..As a whole, these results suggest that the activation of the PI-3K/Akt pathway contributes to the process of JSRV-induced cell transformation but most likely is not the primary determinant both in vitro and in vivo...
- Establishment of permanent cell lines by Epstein-Barr virus transformationJ Gilbert
Duke University Medical Center, Durham, North Carolina, USA
Curr Protoc Hum Genet . 2001..Virus stocks are prepared from cultures of an infected marmoset cell line in the first support protocol. Transformed cells may be analyzed immediately or frozen for future use as described in the second support protocol...
- Functional interaction of common gamma-chain and growth hormone receptor signaling apparatusMarsilio Adriani
Department of Pediatrics, Federico II University, Naples, Italy
J Immunol 177:6889-95. 2006..These data also confirm that growth failure in X-SCID is primarily related to the genetic alteration of the IL2RG gene...
- Role of Epstein-Barr virus-encoded latent membrane protein 2A on virus-induced immortalization and virus activationK Konishi
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, 060-8638 Sapporo, Japan
J Gen Virol 82:1451-6. 2001..The results raise a question as to the role of LMP2A in inhibition of disruption of virus latency in vivo, where LMP2A expression has been expected to be low as in Akata cells...
- Immortalization of Epstein-Barr virus-negative human B lymphocytes with minimal chromosomal instabilityYoriko Yamashita
Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Pathol Int 56:659-67. 2006..Furthermore, using this system, it is possible to analyze the role of individual genes in human B lymphocyte immortalization without the influence of a pre-existing Epstein-Barr virus genome...
- Long-term expression of a transferred gene in Epstein-Barr virus transformed human B cellsG X Shi
Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
Scand J Immunol 54:265-72. 2001....
- Generation of Epstein-Barr Virus (EBV)-immortalized B cell linesGiovanna Tosato
National Cancer Institute, Bethesda, Maryland, USA
Curr Protoc Immunol . 2007..The protocol described in this unit to accomplish this can be divided into three stages: preparation of virus, preparation of target cells to be immortalized, and EBV infection and growth of infected cells...
- EBV-specific CD4+ T cell clones exhibit vigorous allogeneic responsesElise Landais
Institut National de la Sante et de la Recherche Medicale, Unite 601, Institut de Biologie, Nantes, France
J Immunol 177:1427-33. 2006..As already proposed, the strong alloreactivity toward LCLs suggest that these cells could be used for selective depletion of alloreactive T cells...
- Stochastic cancer progression driven by non-clonal chromosome aberrationsHenry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Cell Physiol 208:461-72. 2006..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
- Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosisY C Kim
Department of Biochemistry, Yonsei University, 134 Shinchondong, Seodaemungu, Seoul, Korea 120-749
Oncogene 20:16-23. 2001..Data presented here firmly established the oncogenic potential of HBx during multistage carcinogenesis. Oncogene (2001) 20, 16 - 23...
- Cell cycle arrest and lytic induction of EBV-transformed B lymphoblastoid cells by a histone deacetylase inhibitor, Trichostatin AJ S Seo
Research Institute of Immunobiology, Catholic University, Seoul 137 701, Japan
Oncol Rep 19:93-8. 2008..These results suggest that TSA may exert an enhanced anti-tumor effect for EBV-associated tumors not only by inducing a cell cycle arrest and apoptosis, but also by triggering an EBV lytic cycle...
- The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activationK M Izumi
Department of Medicine, Brigham and Women s Hospital, and Channing Laboratories, Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115 5804, USA
Mol Cell Biol 19:5759-67. 1999..These results add a different perspective to the molecular interactions through which LMP1, TRADD, and RIP participate in B-lymphocyte activation and growth...
- The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virusHelmut Kutz
GSF National Research Center for Environment and Health, Department of Gene Vectors, Marchioninistrasse 25, D 81377 Munich, Germany
Virology 371:246-56. 2008..Our data support a critical role of the LMP1-induced JNK pathway for proliferation of LMP1-transformed cells and characterize JNK as a potential target for intervention against EBV-induced malignancies...
- Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variantJ E Cleaver
Department of Dermatology, University of California at San Francisco, 94143 0750, USA
Cancer Res 59:1102-8. 1999..The symptoms of elevated solar carcinogenesis in XPV patients may, therefore, be associated with increased genomic instability in cells of the skin in which p53 is inactivated by UV-induced mutations...
- The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaBK M Izumi
Department of Microbiology and Molecular Genetics, Harvard Medical School and Medicine, Brigham and Women s Hospital, Eighth Floor Channing Laboratories, 181 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 94:12592-7. 1997..These results indicate that LMP1 appropriates TRADD to enable efficient long-term lymphoblastoid cell outgrowth. High-level NF-kappaB activation also appears to be a critical component of long-term outgrowth...
- Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cellsX J Guo
Cancer Research Laboratory, University of Western Ontario, London, Canada
Cell Growth Differ 1:333-8. 1990..In addition, high 5B10 mRNA levels were associated with metastatic ability in a series of ras-transformed cells, in proportion to levels of ras p21 expressed by the cells, implicating 5B10 even more deeply in carcinogenesis...
- NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cellsE D Cahir-McFarland
The Channing Laboratory and Department of Infectious Diseases, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02130, USA
Proc Natl Acad Sci U S A 97:6055-60. 2000..However, caspase inhibition failed to block apoptosis. These experiments indicate that NF-kappaB inhibitors may be useful in the therapy of EBV-induced cellular proliferation...
- Differential regulation of human RecQ family helicases in cell transformation and cell cycleT Kawabe
AGENE Research Institute, Kamakura, Kanagawa, Japan
Oncogene 19:4764-72. 2000..Our results support the view that the levels of WRN, BLM, RTS and RecQL1 are differentially up-regulated to guarantee genomic stability in cells that are transformed or actively proliferating...
- Generation of continuously growing B cell lines by epstein-barr virus transformationW E Biddison
National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA
Curr Protoc Cell Biol . 2001..In this unit, Epstein-Barr virus produced by a marmoset cell line is used to transform B cells into a continuously growing cell line that produces no virus. These cell lines can be used as a constant source of cells for further study...
- Quantitative analysis of human leucocyte antigen expression during culture of Epstein-Barr virus-transformed cell lines using the dako QIFIKITR Battle
Transplant Immunology, St James University Hospital, Leeds
Br J Biomed Sci 64:32-4. 2007....
- Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformationS C Murthy
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772
J Virol 63:3307-14. 1989..5 kilobases). Although some analogies can be drawn between STP and LMP (lymphocyte membrane protein) of Epstein-Barr virus, STP is not related in sequence to LMP...
- RESEARCH TRAINING FOR VETERINARY STUDENTSMichael Lairmore; Fiscal Year: 2005....
- MOLECULAR AND ONCOLOGIC VIROLOGY TRAINING PROGRAMDaniel DiMaio; Fiscal Year: 2005..In these capacities, he is well positioned to foster interactions among other members of the faculty in the School of Medicine. ..
- ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAINDaniel DiMaio; Fiscal Year: 2004..These experiments should provide new insights into the function and regulation of receptor tyrosine kinases and into human tumorigenesis, and they should elucidate the binding properties of a new family of WW domains. ..
- Mechanism of p12I and p30II in HTLV1 InfectionMichael Lairmore; Fiscal Year: 2003..Our long-term goal is to understand the role of p12-I and p30-II in the establishment of HTLV-1 infection in vivo. ..
- Role of HPV16 E7/E2F6 interaction in viral oncogenesisMargaret McLaughlin Drubin; Fiscal Year: 2006..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
- The Role of HIV-1 Vpu in the Regulation of CD40Ashlee Moses; Fiscal Year: 2009..Successful completion of these Aims will lead to an increased understanding of both CD40 regulation and Vpu function, and may identify targets of immune modulatory and/or anti-viral significance. ..
- Identifying cellular genes as anti-HIV drug targetsAshlee Moses; Fiscal Year: 2003..The company intends to develop intellectual property protection for the use of novel validated genes in antiviral drug assays, and pursue the development of such drugs. ..
- ANIMAL MODELS OF MOLECULAR PATHOGENSIS OF HTLV-1Michael Lairmore; Fiscal Year: 2003..Collectively, our research groups provide a coordinated approach to develop state-of-the-art animal models to further knowledge of the events of HTLV-1 pathogenesis. ..
- HIV INFECTED ENDOTHELIUM AND NONHODGKINS LYMPHOMAAshlee Moses; Fiscal Year: 2002..Identification of these mechanisms may suggest therapeutic targets to prevent development of extranodal B cell neoplasms. ..
- Role of Epstein-Barr virus LMP1 in lymphomaKENNETH IZUMI; Fiscal Year: 2009....
- Molecular Therapy Core CentersArthur Miller; Fiscal Year: 2008..abstract_text> ..
- Carl Zeiss LSM 510 Confocal Inverted Microscope SystemChou Zen Giam; Fiscal Year: 2008..This instrumentation request is thus of obvious importance to the overall mission of the NIH, to fund research that will improve public health. [unreadable] [unreadable] [unreadable]..
- 2007 Molecular Biology of Hepatitis B Viruses MeetingWilliam Mason; Fiscal Year: 2007..Limited support for meeting materials and organizational[unreadable] functions is also needed. ..
- ROLE OF AMPK IN TUMOR DEVELOPMENT AND THERAPYKeith R Laderoute; Fiscal Year: 2010..Ultimately, we intend to determine whether the AMPK "emergency stress response" can be exploited for the therapy or prognosis of human cancer. ..
- Identifying small molecule inhibitors of KSHV vFLIP-TRAF2 interactions.Ethel Cesarman; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Phenotypes of HIV-1 IntegrasesWilliam Robinson; Fiscal Year: 2009..Inhibitors of integrase are in clinical testing. Understanding how HIV becomes resistant to these compounds and how such compounds interact with integrase are fundamental to the synthesis of better anti-HIV drugs. ..
- Herpes Simplex Virus Transmission Across Cell JunctionsDavid Johnson; Fiscal Year: 2007..unreadable] [unreadable]..
- SULFATE CONJUGATION AND DRUG METABOLISMRichard Weinshilboum; Fiscal Year: 2007....
- BH3-only protein BNIP3 in tumor progressionGOVINDASWAMY CHINNADURAI; Fiscal Year: 2006..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
- ROLE OF TNF IN BLADDER INFLAMMATIONDavid J Klumpp; Fiscal Year: 2010..This project will determine the prevalence of RANTES as a novel IC biomarker in urines and then quantify the efficacy of mechanistically-directed therapies in murine models. ..
- Oncogenic properties of interferon regulatory factor 7Luwen Zhang; Fiscal Year: 2009..This study should provide an insight of how IRF-7 participates in EBV transformation, and expand our knowledge about IRFs as well as the pathogenesis of EBV-associated CNS lymphoma. ..
- Macrophages Role in the Development of HIV LipoatrophyDeirdre Killebrew; Fiscal Year: 2008..abstract_text> ..
- Developmental Checkpoints of Murine Mast CellsKoichi Akashi; Fiscal Year: 2009..Results obtained from this project will be critical to study mast cell biology, which eventually will help develop new therapeutic strategies for a variety of allergic and autoimmune disorders. ..
- FUNCTIONS OF E2A IN B LYMPHOCYTE DEVELOPMENTYuan Zhuang; Fiscal Year: 2009..abstract_text> ..
- Role of Wnt signaling in Cervical Cancer PathogenesisAykut Uren; Fiscal Year: 2010..Aykut The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
- Computer Simulation of Epstein Barr Virus InfectionDavid Thorley Lawson; Fiscal Year: 2009..e. cure) of the virus is realistic or even possible. ..
- Virus Specific CTL following T cell depleted SCTKenneth Lucas; Fiscal Year: 2009....
- Virus-Like Particle Vaccine for SARS-CoVRAPHAEL PAUL VISCIDI; Fiscal Year: 2010..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
- HYPOXIC STRESS MECHANISMS IN RADIATION AND CHEMOTHERAPYKeith Laderoute; Fiscal Year: 2009..An understanding of these MTF-1-dependent properties should aid in the development of novel prognostic and new modalities for neoplastic diseases. ..
- MOLECULAR MECHANISMS IN NEOPLASIAPaul Neiman; Fiscal Year: 2008..In this fashion we hope to establish whether Myc-induced genomic instability merits wider exploration in human neoplasm. [unreadable] [unreadable] [unreadable] [unreadable]..
- Epstein-Barr Virus: Activation of WNTNancy Raab Traub; Fiscal Year: 2008..A detailed understanding of the activation of this pathway may provide new opportunities for treatment of EBV-associated cancers and also of similar cancers considered EBV-negative, that develop in the immunosuppressed. ..
- Lineage decision in blood stem and progenitor cellsKoichi Akashi; Fiscal Year: 2007..Thus, we hope these studies will help understand mechanistic effects of these transcription factors on lineage decision in normal and malignant hematopoietic development. ..
- KSHV TRANSFORMATION AND ANGIOGENESIS IN KAPOSIS SARCOMAEthel Cesarman; Fiscal Year: 2001..These studies will also provide information that will enrich our general knowledge of viral oncogenesis. ..
- BD FACSAria Flow Cytometer Cell SorterChou Zen Giam; Fiscal Year: 2005..Sorting time may be made available to investigators outside of the USUHS community from time to time when the instrument would otherwise not be used. ..
- NK AND T CELL COSTIMULATION BY NKG2D/DAP10LEWIS LANIER; Fiscal Year: 2005..Given the broad distribution of MICA/B on freshly isolated human tumors, studies of the NKG2D-DAP10 receptor may provide new opportunities for immunotherapeutic intervention in cancer. ..
- Viruses and Autoimmunity ot the Central Nervous SystemROBERT FUJINAMI; Fiscal Year: 2004..Our model could provide an explanation why no single microbe has been identified as the MS agent but is likely to be a combination of infectious events. ..
- Hamster Model for AIDS LymphomasJANET BUTEL; Fiscal Year: 2003..In addition, this project may provide new insights into lymphomagenesis in general and may lead to the development of new diagnostic and therapeutic approaches to this malignancy. ..
- ARSENIC TRIOXIDE TREATMENT OF LYMPHOPROLIFERATIVE DISORDSamuel Waxman; Fiscal Year: 2003..Should our laboratory study identify agents or schedules that enhance the response to As203, we will use them to appropriately modify the initial phase II pilot study. ..
- ANTILEUKEMIA ACTIVITY OF PERILLYL ALCOHOLSteven Clark; Fiscal Year: 2003..abstract_text> ..
- TRAF Regulation and Receptor Interactions in TNFR Family SignalsGAIL BISHOP; Fiscal Year: 2009..To explore the role of TRAF5 in B cell activation. ..
- Institute of Human Virology Annual Meeting 2002-2004Robert Gallo; Fiscal Year: 2002..abstract_text> ..
- MECHANISM OF HPV E2 MEDIATED CELLULAR GROWTH SUPPRESSIONPeter Howley; Fiscal Year: 2002..In this grant application, we propose to examine the mechanisms by which E2 causes cellular growth suppression. ..
- BIOCHEMICAL MECHANISM OF TRANSACTIVATION IN HTLV 1Chou Zen Giam; Fiscal Year: 2002....
- JSRV AND OVINE PULMONARY CARCINOMAJames DeMartini; Fiscal Year: 2001..All of these techniques have been done by the investigators involved. Similar studies, in some cases without the advantage of the newer techniques, have been used with success in other studies of retroviral-associated neoplasia. ..
- Immunologic Factors In Progressive Autoimmune DiseaseROBERT FUJINAMI; Fiscal Year: 2005..These new models could help explain the transition from RR disease to progressive disease often observed in MS patients. ..
- Oncogenesis In Retrovirus-Induced Lung CancerMassimo Palmarini; Fiscal Year: 2005..The completion of these experiments will clarify the molecular mechanisms of JSRV-induced pulmonary carcinogenesis and might furnish an intellectual framework to unravel the pathogenesis of some forms of human lung cancer. ..
- Interferon Regulatory Factor 7 and NPCLuwen Zhang; Fiscal Year: 2006..This study would lead to a better understanding of how LMP-1 and IRF-7 interact to participate in viral pathogenesis, latency, and transformation. ..
- FORMAL METHODS APPLIED TO BIOLOGICAL SIGNALING NETWORKSKeith Laderoute; Fiscal Year: 2006..abstract_text> ..
- A NOVEL VECTOR FOR VACCINATION AGAINST HEPETITIS C VIRUSNikolaus Osterrieder; Fiscal Year: 2006..The tests will include ELISPOT and CTL assays in the context of a human class I allele using HLA-A2.1 transgenic mice. ..
- MOLECULAR PATHOGENESIS OF SPINAL MUSCULAR ATROPHYElliot Androphy; Fiscal Year: 2004..Furthermore, SMN point mutants from SMA patients show defective oligomerization proportional to their disease severity. These studies have defined the genetic and biochemical basis for development of SMA. ..
- Papillomavirus Inhibitors for AIDS-related MalignanciesElliot Androphy; Fiscal Year: 2005..The optimal cellular delivery system for the best inhibitors will be defined. The overall goal is to achieve high potency in cell-based models for eventual testing in animals and in human clinical trials. ..
- VZV BACs: New Tools for Pathogenesis ResearchNikolaus Osterrieder; Fiscal Year: 2005..B-scid/beige mice, and infected MeWo or MeWo-9 cells will be used to inoculate the grafts. Virus replication in the implants will be examined by virus titrations, real-time PCR, histopathology and immunohistochemistry. ..
- Genetic system for thesus monkey rhadinovirus (RRV)Blossom Damania; Fiscal Year: 2005..In addition, it would also help us shed light on the lifecycle and pathogenesis of the gamma herpesvirus family, in general. ..
- Molecular Epidemiology of N. gonorrhoeaeRaphael Viscidi; Fiscal Year: 2006..gonorrhea in the core. The third aim is to determine whether gender, age, or disseminated versus local infection influences the population genetic structure of N. gonorrhea. ..
- SV40 T Antigen Role in Virus Growth and TransformationJames M Pipas; Fiscal Year: 2010..3. Distinguish the relative roles of the T antigen HR domain and the viral miRNAs in SV40 infection. 4. Determine whether T antigen autoregulation contribute to CTL evasion? ..
- IBD--MUCOSA-SPECIFIC REGULATION OF IFN-GAMMA PRODUCTIONStephan Targan; Fiscal Year: 2005..abstract_text> ..
- HEPADNAVIRUS INFECTIONS AND LIVER CANCERWilliam Mason; Fiscal Year: 2009..abstract_text> ..
- LSRII Four Laser Analytical Flow CytometerDavid Thorley Lawson; Fiscal Year: 2006..This renders the acquisition of a new LSR II essential, if we are to meet the flow cytometry needs, both in time and available technology, for the community of NIH funded researchers at TUSM and T-NEMC. [unreadable] [unreadable]..
- Molecular Functions of the Adenovirus E1A OncogeneMaurice Green; Fiscal Year: 2006..The functional consequences of interaction between E1A and specific cellular promoters will be established by kinetic studies of the gene specific mRNA and protein products. ..
- Mechanism of HTLV-1 LeukemogenesisChou Zen Giam; Fiscal Year: 2006..Aim 2: Tax, PP2A, and cell cycle control. Aim 3: Use of Saccharomyces cerevisiae as a model to study cell cycle abnormalities induced by Tax. ..
- ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATESRaphael Viscidi; Fiscal Year: 2001..of incident HPV infection and/or disease? (6) In HIV seropositive women, is the extent of immunodeficiency, as measured by CD4+ cell counts, inversely correlated with the degree of protection provided by pre-existing anti-VLP antibodies? ..
- The Roles of IRF-3 in the Cellular Response to Viral InfectionPeter Howley; Fiscal Year: 2007..We will explore this pathway and examine the mechanisms by which some viruses inactivate this pathway for the replication of the virus and the survival of the infected cell. ..
- High Throughput Screen for Compounds to Treat Papillomavirus Induced CancersElliot Androphy; Fiscal Year: 2007..Success would impact the health of millions of women and men afflicted with HPV infections and associated malignancies. [unreadable] [unreadable] [unreadable]..