neuroepithelial neoplasms

Summary

Summary: Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)

Top Publications

  1. ncbi [Dysembryoplastic neuroepithelial tumors]
    C Daumas-Duport
    Laboratoire d Anatomie Pathologique, Hopital Sainte Anne, Paris
    Rev Neurol (Paris) 159:622-36. 2003
  2. ncbi Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization
    D J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Brain Pathol 10:342-52. 2000
  3. ncbi Surgical management of temporal lobe tumor-related epilepsy in children
    Oguz Cataltepe
    Departments of Neurosurgery and Pediatric Neurology, Hacettepe University Medical School, Ankara, Turkey
    J Neurosurg 102:280-7. 2005
  4. ncbi Papillary glioneuronal tumor--a new variant of benign mixed brain neoplasm
    Radzisław Kordek
    Department of Pathology, Chair of Oncology, Medical University, Lodz
    Pol J Pathol 54:75-8. 2003
  5. ncbi The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 cases
    Carla Fernandez
    Department of Pathology and Neuropathology, Hopital d Enfants de la Timone, Marseille, France
    AJNR Am J Neuroradiol 24:829-34. 2003
  6. ncbi Nonmalignant pediatric brain tumors
    Mahmoud Rashidi
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Curr Neurol Neurosci Rep 3:200-5. 2003
  7. ncbi A rare case of dysembryoplastic neuroepithelial tumour in occipital lobe presenting with only headache
    Hideo Hamada
    Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Clin Neurosci 10:276-8. 2003
  8. ncbi [Dysembryoplastic neuroepithelial tumors in children]
    M J Muñoz-Muñoz
    Rev Neurol 45:58-60. 2007
  9. ncbi A 52-year-old man with progressive left-sided weakness and white matter disease
    John O Fleming
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 44901, USA
    Neurology 69:600-6. 2007
  10. ncbi Use of proton magnetic resonance spectroscopy of the brain to differentiate gliomatosis cerebri from low-grade glioma
    Damien Galanaud
    Centre de Resonance Magnetique Biologique et Medicale, Unite Mixte de Recherche, Centre National de Recherche Scientifique 6612, Faculte de Medecine, Universite de la Mediterranee, and Hôpital de La Timone, Marseille, France
    J Neurosurg 98:269-76. 2003

Detail Information

Publications230 found, 100 shown here

  1. ncbi [Dysembryoplastic neuroepithelial tumors]
    C Daumas-Duport
    Laboratoire d Anatomie Pathologique, Hopital Sainte Anne, Paris
    Rev Neurol (Paris) 159:622-36. 2003
    ..DNTs should therefore be operated soon after diagnosis. However, excellent results can also be obtained by epilepsy surgery in patients with long term drug resistant partial seizures...
  2. ncbi Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization
    D J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Brain Pathol 10:342-52. 2000
    ....
  3. ncbi Surgical management of temporal lobe tumor-related epilepsy in children
    Oguz Cataltepe
    Departments of Neurosurgery and Pediatric Neurology, Hacettepe University Medical School, Ankara, Turkey
    J Neurosurg 102:280-7. 2005
    ..In this study the authors review the clinical, pathological, and radiological features as well as outcome data obtained in 29 pediatric patients with temporal lobe tumor-related epilepsy and discuss the surgical treatment strategies...
  4. ncbi Papillary glioneuronal tumor--a new variant of benign mixed brain neoplasm
    Radzisław Kordek
    Department of Pathology, Chair of Oncology, Medical University, Lodz
    Pol J Pathol 54:75-8. 2003
    ..From this point of view it is important to remember that such a wide spectrum may be difficult to discriminate into very narrow clinico-pathological entities...
  5. ncbi The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 cases
    Carla Fernandez
    Department of Pathology and Neuropathology, Hopital d Enfants de la Timone, Marseille, France
    AJNR Am J Neuroradiol 24:829-34. 2003
    ..The goal of our study was to better characterize the clinical-radiologic-pathologic spectrum of DNTs (complex and simple forms only) in a series of 14 children...
  6. ncbi Nonmalignant pediatric brain tumors
    Mahmoud Rashidi
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Curr Neurol Neurosci Rep 3:200-5. 2003
    ..Advances in the therapeutic management of patients with these tumors have considerably improved their prognosis...
  7. ncbi A rare case of dysembryoplastic neuroepithelial tumour in occipital lobe presenting with only headache
    Hideo Hamada
    Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Clin Neurosci 10:276-8. 2003
    ..The lesion was totally resected and histopathologically diagnosed as DNT. Physicians must bear in mind that DNT may occur in the occipital lobe and present with only mass effect...
  8. ncbi [Dysembryoplastic neuroepithelial tumors in children]
    M J Muñoz-Muñoz
    Rev Neurol 45:58-60. 2007
  9. ncbi A 52-year-old man with progressive left-sided weakness and white matter disease
    John O Fleming
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 44901, USA
    Neurology 69:600-6. 2007
  10. ncbi Use of proton magnetic resonance spectroscopy of the brain to differentiate gliomatosis cerebri from low-grade glioma
    Damien Galanaud
    Centre de Resonance Magnetique Biologique et Medicale, Unite Mixte de Recherche, Centre National de Recherche Scientifique 6612, Faculte de Medecine, Universite de la Mediterranee, and Hôpital de La Timone, Marseille, France
    J Neurosurg 98:269-76. 2003
    ....
  11. ncbi Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:383-9. 2007
    ..Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed...
  12. ncbi Glioblastoma multiforme and ascending weakness
    L J Cooke
    Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Calgary, AB, Canada
    Can J Neurol Sci 29:372-4. 2002
  13. ncbi The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours
    D F O'Brien
    Department of Neurosurgery, Epilepsy Surgery Programme, Beaumont Hospital, Dublin, Ireland
    Br J Neurosurg 21:539-49. 2007
    ..It is not advocated to use a stereotactic biopsy only, as this may generate an unrepresentative tissue sample consisting of an oligodendroglial component only and may lead to an incorrect diagnosis...
  14. ncbi Various findings in surgically treated epilepsy patients with dysembryoplastic neuroepithelial tumors in comparison with those of patients with other low-grade brain tumors and other neuronal migration disorders
    Rolf Degen
    Epilepsy Centre Bethel, Bielefeld, Germany
    Epilepsia 43:1379-84. 2002
    ....
  15. ncbi Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report
    M Majores
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Clin Neuropathol 26:311-6. 2007
    ..We report on a 46-year-old male patient with pharmacoresistant temporal lobe epilepsy (TLE). Based on ictal EEG patterns and MRI scans, Ammon's horn sclerosis (AHS) or an epilepsy-associated tumor was included in the differential diagnosis...
  16. ncbi Chromosome 1p allelic loss by fluorescence in situ hybridization is not observed in dysembryoplastic neuroepithelial tumors
    Richard A Prayson
    Department of Neurological Surgery, Cleveland Clinic Foundation, OH 44195, USA
    Am J Clin Pathol 118:512-7. 2002
    ..LOH on chromosome 1p may be a useful differential diagnostic feature (favoring oligodendroglioma) in a subset of cases in which specimen fragmentation or size raises the differential diagnosis of DNT vs oligodendroglioma...
  17. ncbi Histological and MR correlations in Gliomatosis cerebri
    Paule Peretti-Viton
    Department of Neuroradiology, Timone Hospital, Marseilles, France
    J Neurooncol 59:249-59. 2002
    ..Response to therapy could not clearly be observed in GC, despite oligodendroglial component in 6/9 cases. Prognosis of GC was constantly poor...
  18. ncbi Surgical strategies and seizure control in pediatric patients with dysembryoplastic neuroepithelial tumors: a single-institution experience
    Krasimir Minkin
    Department of Pediatric Neurosurgery, University Hospital La Timone, Marseille, France
    J Neurosurg Pediatr 1:206-10. 2008
    ..The authors present a study of long-term seizure outcome after noninvasive presurgical investigations and different surgical strategies were used in a series of pediatric patients...
  19. ncbi MRI of long-term epilepsy-associated tumors
    Horst Urbach
    Department of Radiology Neuroradiology, University of Bonn Medical Center, Bonn, Germany
    Semin Ultrasound CT MR 29:40-6. 2008
    ..This distinction is important since more than 70% of patients with drug resistant temporal lobe epilepsy caused by gangliogliomas and DNTs get seizure free following extended lesionectomy...
  20. ncbi Malignant astroblastoma with rhabdoid morphology
    Serguei I Bannykh
    8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Neurooncol 83:277-8. 2007
  21. ncbi Neuroradiologic characteristics of astroblastoma
    John W Bell
    Department of Radiology, University of Utah, 50 North Medical Drive, Salt Lake City, UT, 84132, USA
    Neuroradiology 49:203-9. 2007
    ..We report the largest imaging series to date and further delineate the CT and MRI features of astroblastoma. We identify those features that may be useful in distinguishing astroblastoma from other neoplasms...
  22. ncbi Seizure outcome of lesionectomy in glioneuronal tumors associated with epilepsy in children
    Marco Giulioni
    Department of Neurosciences, Bellaria Hospital, Bologna, Italy
    J Neurosurg 102:288-93. 2005
    ..To address this uncertainty, the authors analyzed seizure outcome in a series of children with epileptogenic glioneuronal tumors that had been treated only by lesionectomy...
  23. ncbi Clinical diagnosis of gliomatosis cerebri: report of three cases
    Jiro Akimoto
    Department of Neurosurgery and Pathology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Brain Tumor Pathol 21:87-95. 2004
    ..Diagnosis of GC should be faithful to the pathological diagnosis criteria of Scheinker and Evans, and therefore the precise assessment of MRI findings according to these criteria is required for clinical, antemortem diagnosis of GC...
  24. pmc Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion
    T Suzuki
    Department of Neurosurgery, Osaka University Medical School, 2 2, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Clin Pathol 58:166-71. 2005
    ..Because the nosological definition and histogenesis of GC remain controversial, the morphology and immunohistochemical staining patterns of neoplastic GC cells were compared with those of other gliomas...
  25. ncbi Multifocal dysembryoplastic neuroepithelial tumour in a male with the XYY syndrome
    B K Krossnes
    Neuropathol Appl Neurobiol 31:556-60. 2005
  26. ncbi Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy
    S Vogelgesang
    Department of Neuropathology, University of Greifswald, Germany
    Clin Neuropathol 23:223-31. 2004
    ..There is mounting evidence that multidrug transporters such as P-glycoprotein (P-gp) or multidrug resistance-associated proteins (MRP) play an important role in the development of resistance to antiepileptic drugs (AED)...
  27. pmc Astroblastoma: a case report
    Dong Sug Kim
    Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea
    J Korean Med Sci 19:772-6. 2004
    ..2, while showing negativity for synaptophysin, neurofilament protein, pan-cytokeratin and high molecular weight keratin...
  28. pmc [11C]-Methionine PET: dysembryoplastic neuroepithelial tumours compared with other epileptogenic brain neoplasms
    D S Rosenberg
    CERMEP, Hopital Neurologique, 59 Bd Pinel, Lyon 69003, France
    J Neurol Neurosurg Psychiatry 76:1686-92. 2005
    ..This study tested whether [(11)C]-methionine positron emission tomography (MET-PET) could help to distinguish DNTs from other epileptogenic brain tumours...
  29. ncbi Initial chemotherapy in gliomatosis cerebri
    M Sanson
    Fédération de Neurologie Mazarin, Groupe hospitalier Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France
    Neurology 63:270-5. 2004
    ..Because of the diffuse nature of gliomatosis cerebri (GC), surgery is not suitable, and large field radiotherapy carries the risk of severe toxicity. In this setting, initial chemotherapy warrants further investigation...
  30. ncbi Gliomatosis cerebri: better definition, better treatment
    Marc C Chamberlain
    Neurology 63:204-5. 2004
  31. ncbi Gliomatosis cerebri may present as an atypical parkinsonian syndrome
    Eric S Molho
    Albany Medical College, Department of Neurology, Albany, New York, USA
    Mov Disord 19:341-4. 2004
    ..The patient died 4 years after the onset of symptoms. Pathological examination revealed diffuse infiltration of multiple brain regions with cells of astrocytic and microglial origin consistent with a diagnosis of gliomatosis cerebri...
  32. pmc Parkinsonism and dementia due to gliomatosis cerebri mimicking sporadic Creutzfeldt-Jakob disease (CJD)
    M Slee
    J Neurol Neurosurg Psychiatry 77:283-4. 2006
  33. ncbi Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation
    Toshihiko Kubota
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, Yoshida gun, Fukui, Japan
    Neuropathology 26:72-81. 2006
    ..Numerous microvilli protruded and basal lamina abutted on the tumor cell surface. We report these unique histological features, and stress that astroblastoma should be categorized as a specific type of neuroepithelial tumor...
  34. ncbi [Gliomatosis cerebri: report of 3 cases and review of recent literatures]
    Masayuki Arai
    Department of Neurosurgery, Fukui Prefectural Hospital, Yotsui 2 8 1, Fukui City 910 8526, Japan
    No To Shinkei 55:890-7. 2003
    ..Case 3 improved in response to radiotherapy and chemotherapy using procarbazine/MCNU/vincristine (MVP). We also reviewed recent literatures...
  35. ncbi Clinical features and epileptogenesis of dysembryoplastic neuroepithelial tumor
    Min Cheol Lee
    Department of Pathology, Chonnam National University Medical School and Hospital, 5 Hakdong, Dongku, Gwangju, 501 746, South Korea
    Childs Nerv Syst 22:1611-8. 2006
    ..Dysembryoplastic neuroepithelial tumor (DNT) frequently causes medically intractable epilepsy...
  36. ncbi Gliomatosis cerebri: 20 years of experience at the Children's Hospital of Philadelphia
    Gregory T Armstrong
    Division of Oncology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer 107:1597-606. 2006
    ..In this report, the authors describe the largest cohort of children to date with GC and explore relations between potential prognostic factors, treatment, and survival...
  37. ncbi Expression of CD34 as a novel marker for glioneuronal lesions associated with chronic intractable epilepsy
    P Deb
    Department of Pathology, All India Institute of Medical Sciences AIIMS, New Delhi, India
    Neuropathol Appl Neurobiol 32:461-8. 2006
    ....
  38. ncbi CD9 expression in solid non-neuroepithelial tumors and infiltrative astrocytic tumors
    Masatou Kawashima
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Histochem Cytochem 50:1195-203. 2002
    ..This might be explained by the observation that the CD9 molecule is associated with a mitogenic factor, membrane-anchored heparin-binding epidermal growth factor, which is known to be upregulated in malignant gliomas...
  39. ncbi Gliomatosis of the brain and spinal cord masquerading as infective lesions
    George Meligonis
    Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa
    Surg Neurol 57:399-404; discussion 404. 2002
    ..The clinico-pathological problems and difficulties in the ante-mortem diagnosis as well as the clinical and pathological similarities to infective lesions are evaluated...
  40. ncbi Central nervous system medulloepithelioma: a series of eight cases including two arising in the pons
    P T Molloy
    Department of Pathology, The Children s Hospital of Philadelphia, Department of Pathology, The Children s Hospital of Philadelphia Pennsylvania, USA
    J Neurosurg 84:430-6. 1996
    ..Medulloepithelioma, often confused with less aggressive PNETs, can mimic intrinsic brainstem glioma, responds poorly to treatment, and is prone to CNS dissemination at the time of tumor progression...
  41. ncbi Gliomatosis cerebri: pitfalls in diagnosis
    P Rust
    Department of Neurosurgery, Atkinson Morley's Hospital, London, UK
    J Clin Neurosci 8:361-3. 2001
    ..Magnetic resonance imaging was required to show the lesions with greater definition; however, in both cases, a biopsy was needed to confirm the diagnosis...
  42. ncbi Gliomatosis cerebri in a 10-year-old girl masquerading as diffuse encephalomyelitis and spinal cord tumour
    S Jayawant
    Department of Paediatric Neurology, University Hospital of Wales, Heath Park, Cardiff, UK
    Dev Med Child Neurol 43:124-6. 2001
    ..A diffuse encephalomyelopathy occurred, which was complicated by spinal cord swelling, followed by deterioration and death. Gliomatosis cerebri affecting the brain and spinal cord was found at postmortem examination...
  43. ncbi Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma
    John D Port
    Neuroradiology Division, Johns Hopkins Hospital, Baltimore, MD, USA
    AJNR Am J Neuroradiol 23:243-7. 2002
    ..The solid component of the mass has a bubbly appearance and a T2 signal that is isointense to gray matter. Punctate calcifications are often present. Neuroradiologists should be familiar with the characteristic appearance of this tumor...
  44. ncbi Gliomatosis cerebri
    Stuart S Kaplan
    Department of Neurological Surgery, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Pediatr Neurosurg 36:111-2. 2002
  45. ncbi Dysembryoplastic neuroepithelial tumors in childhood: long-term outcome and prognostic features
    M A Nolan
    Brain and Behavior Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada
    Neurology 62:2270-6. 2004
    ..The authors describe the clinical, radiologic, and pathologic characteristics and outcomes in children after surgical resection of pathologically confirmed DNT to ascertain prognostic features for seizure recurrence following surgery...
  46. ncbi Combined positron emission tomography and magnetic resonance imaging for the planning of stereotactic brain biopsies in children: experience in 9 cases
    Benoit Pirotte
    Department of Neurosurgery, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Pediatr Neurosurg 38:146-55. 2003
    ....
  47. ncbi [Seizures and recurrent left hemiparesia (clinical conference)]
    K Hoang-Xuan
    Fédération de Neurologie Mazarin, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Rev Neurol (Paris) 158:369-76. 2002
  48. ncbi [Case no 1. Neuroepithelial dysembryoplastic tumor]
    F Brami-Zylberberg
    Département d imagerie Morphologique et Fonctionelle, Centre Hospitalier Sainte Anne, Paris
    J Radiol 84:78-9. 2003
  49. ncbi Telomerase activity and alterations in telomere length in human brain tumors
    S Hiraga
    Department of Neurosurgery, Osaka University Medical School, Suita, Japan
    Cancer Res 58:2117-25. 1998
    ..These findings suggest that telomerase activity can be an index of malignant potential or malignancy itself in nonneuroepithelial brain tumors...
  50. ncbi Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 101:383-92. 2001
    ..In addition, since these neurons contain both NMDAR1 and NMDAR2A/B subunits, the BDNF-TrkB pathway may also contribute through a modulation of glutamatergic transmission to the intrinsic epileptogenicity of glioneuronal tumors...
  51. ncbi [Supratentorial tumors]
    I Grunwald
    Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitatsklinikum des Saarlandes, Homburg
    Radiologe 47:471-85. 2007
    ..The supratentorial extracranial tumors include the choroid plexus, colloid cysts, meningeoma, infantile myofibromatosis and lipoma. The most common sub-forms, especially of astrocytoma, will also be presented...
  52. ncbi Allelic losses in oligodendroglial and oligodendroglioma-like neoplasms: analysis using microsatellite repeats and polymerase chain reaction
    Mahlon D Johnson
    Department of Pathology, Vanderbilt Medical School, Nashville, Tenn 37232, USA
    Arch Pathol Lab Med 127:1573-9. 2003
    ..Oligodendroglial tumors are heterogenous neoplasms with histologic features shared with other central nervous system tumors, such as dysembryoplastic neuroepithelial tumors...
  53. ncbi Coexistent pathology in chronic epilepsy patients with neoplasms
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 23:1097-103. 2010
    ..Coexistent pathology may account for the incidence of recurrent or residual epilepsy in patients who undergo tumor resection...
  54. ncbi Differential telomerase expression and telomere length in primary intracranial tumors
    H J Chen
    Department of Neurosurgery, Chang Gung Memorial Hospital, 123, Tao Pei Road, Niaosung, Kaohsiung, Taiwan, R O C
    Chang Gung Med J 24:352-60. 2001
    ..The authors examined telomerase activity and telomere length in intracranial tumors to determine the clinicopathological behavior of primary intracranial tumors with respect to telomerase expression and alteration of telomere length...
  55. ncbi Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults
    Anna Taraszewska
    Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Folia Neuropathol 43:172-7. 2005
    ..To our knowledge, this is the first reported case of pigmented pilocytic astrocytoma exhibiting extensive intracellular hemosiderin deposition...
  56. ncbi Drug-resistance gene expression and progression of astrocytic tumors
    S Tanaka
    Department of Neurosurgery, Kitasato Institute Medical Center Hospital, Kitamoto, Saitama, Japan
    Brain Tumor Pathol 18:131-7. 2001
    ..These findings suggest that native drug resistance is more important than acquired resistance when glioma therapy is considered...
  57. ncbi Rosette-forming glioneuronal tumor: pathology case report
    José Pimentel
    Department of Neurology, Laboratory of Neuropathology, Institute of Molecular Medicine, Hospital de Santa Maria, Lisbon Faculty of Medicine, Lisbon, Portugal
    Neurosurgery 62:E1162-3; discussion E1163. 2008
    ..Rosette-forming glioneuronal tumor is a newly described mixed glial and neuronal tumor. We describe two cases and review the literature to better characterize this entity...
  58. pmc Cytogenetic characterizations of central nervous system tumors: the first comprehensive report from a single institution in Korea
    Kyung Eun Kim
    Department of Laboratory Medicine, Dong A University College of Medicine, Busan, Korea
    J Korean Med Sci 24:453-60. 2009
    ..More detailed cytogenetic and molecular characterizations of CNS tumors contribute to better diagnostic criteria and deeper insights of tumorigenesis, eventually resulting in development of novel therapeutic strategies...
  59. ncbi Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity
    Toshio Uesaka
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurooncol 84:119-29. 2007
    ..Based on these observations, Topo IIalpha and beta mRNA expression, but not the Topo IIalpha labeling index, might be a useful marker for sensitivity to etoposide in human malignant neuroepithelial tumors...
  60. ncbi Immunohistochemistry of primary malignant neuroepithelial tumors of the kidney: a potential source of confusion? A study of 30 cases from the National Wilms Tumor Study Pathology Center
    Dale A Ellison
    Department of Pathology, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Hum Pathol 38:205-11. 2007
    ..We recommend molecular fusion studies for clarification of primitive renal tumors with unexpected immunophenotypic results...
  61. ncbi Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Mod Pathol 22:1600-11. 2009
    ..Thus, annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof...
  62. pmc PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors
    Elisabetta Benedetti
    Department of Basic and Applied Biology, University of L Aquila, 67100 L Aquila, Italy
    PPAR Res 2010:427401. 2010
    ..This review will focus on the major studies dealing with PPAR expression in gliomas and neuroblastoma and the therapeutic implications of using PPAR agonists for the treatment of these neoplasms...
  63. ncbi Giant cell ependymoma: a case report
    Dariusz Adamek
    Department of Neuropathology, Medical College, Jagiellonian University, 3 Botaniczna St, 31 503 Krakow, Poland
    Clin Neurol Neurosurg 110:176-81. 2008
    ..To the best of our knowledge this is the 8th case in the literature. In spite of apparently "worrisome" histology GCE seems to be a neoplasm with a relatively good prognosis...
  64. ncbi Clinical epidemiology for childhood primary central nervous system tumors
    Luc Bauchet
    Department of Neurosurgery, Centre Hospitalo Universitaire, Hopital Gui de Chauliac, 80 avenue Augustin Fliche, 34 295, Montpellier Cedex 5, France
    J Neurooncol 92:87-98. 2009
    ....
  65. ncbi The differential diagnosis of central nervous system tumors: a critical examination of some recent immunohistochemical applications
    Mark A Edgar
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Arch Pathol Lab Med 132:500-9. 2008
    ..These will be used for purposes of tumor subclassification, as prognostic markers, as identifiers of potential therapeutic targets, and as predictors of treatment response...
  66. ncbi Pineal tumors
    Sonika Dahiya
    Department of Pathology, Washington University School of Medicine, St Louis, MO, USA
    Adv Anat Pathol 17:419-27. 2010
    ....
  67. ncbi Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas?
    Tanja Kuhlmann
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Am J Surg Pathol 32:1444-53. 2008
    ..They also support the hypothesis that GBM may be a heterogeneous group of tumors derived from different progenitor cells...
  68. ncbi Schinzel-Giedion syndrome: report of splenopancreatic fusion and proposed diagnostic criteria
    Anna M Lehman
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med Genet A 146:1299-306. 2008
    ..Other highly supportive features include neuroepithelial tumors (found in 17%), hypertrichosis, and brain abnormalities. Severe developmental delay and poor survival are constant features in reported patients...
  69. ncbi Focal cortical dysplasia type II (malformations of cortical development) aberrantly expresses apoptotic proteins
    Wendy A Chamberlain
    Department of Pathology and Laboratory Medicine, Neuropathology Section, Cleveland Clinic, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 16:471-6. 2008
    ....
  70. ncbi Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas
    Stefan Pfister
    Division Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Genes Chromosomes Cancer 46:839-51. 2007
    ..02) were confirmed to be more frequent in medulloblastomas. These data further support the hypothesis of two different tumor entities of embryonal neuroepithelial tumors with characteristic genetic aberrations. (c) 2007 Wiley-Liss, Inc...
  71. ncbi Primary cerebral neuroblastoma: a case report and review
    Volkan Etus
    Kocaeli University Medical School, Department of Neurosurgery, Derince, Turkey
    Tohoku J Exp Med 197:55-65. 2002
    ..A 9-year-old girl with primary cerebral neuroblastoma who was initially misdiagnosed is reported. The other cases from the literature are reviewed and the nature of this rare tumor and its differential diagnosis is discussed...
  72. ncbi Electron microscopy in an oncologic institution. Diagnostic usefulness in surgical pathology
    L Lombardi
    Division of Experimental Oncology A, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italia
    Tumori 74:531-5. 1988
    ..In cases of well-differentiated neuroepithelial tumors, such as carcinoids, EM data was essentially confirmatory of (immuno)-histochemical findings...
  73. ncbi "Ex vivo" release of eicosanoid from human brain tissue: its relevance in the development of brain edema
    P Gaetani
    Department of Surgery, IRCCS Policlinico S Matteo, Italy
    Neurosurgery 28:853-7; discussion 857-8. 1991
    ..56 +/- 0.91). The capacity to synthesize prostacyclin is significantly higher in patients with brain metastasis than in those with neuroepithelial tumors and meningiomas (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)..
  74. pmc Abdominal epilepsy and foreign body in the abdomen--dilemma in diagnosis of abdominal pain
    Noor Topno
    Department of General Surgery, Kasturba Medical College and Hospital, Manipal 576 119, Karnataka State, India
    Yonsei Med J 46:870-3. 2005
    ..On detailed analysis of her medical history and after appropriate investigations, she was diagnosed with temporal lobe epilepsy which was treated with appropriate medications, and which resulted in her pain being relieved...
  75. ncbi Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Front Biosci 8:a1-9. 2003
    ....
  76. ncbi Intracranial ependymoma: factors affecting outcome
    Maura Massimino
    Division of Pediatric Oncology, Istituto Nazionale dei Tumori, Milan, Italy
    Future Oncol 5:207-16. 2009
    ..For high-risk patients, with residual tumor, an interesting, although experimental, approach could be chemotherapy followed by secondary surgery and postoperative conformal irradiation...
  77. ncbi Molecular genetic changes in a series of neuroepithelial tumors of childhood
    Alessia Di Sapio
    Divisione Universitaria di Neurologia, Ospedale San Luigi, Torino, Italy
    J Neurooncol 59:117-22. 2002
    ....
  78. ncbi [Clinicopathologic and radiologic features of dysembryoplastic neuroepithelial tumors]
    Fu Lin Wang
    Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China
    Zhonghua Bing Li Xue Za Zhi 34:566-8. 2005
    ..To study the clinicopathologic features and radiologic findings of dysembryoplastic neuroepithelial tumor (DNT)...
  79. ncbi Psychiatric co-morbidity in 75 patients undergoing epilepsy surgery: lack of correlation with pathological findings
    A M Siegel
    Division of Epilepsy, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Epilepsy Res 80:158-62. 2008
    ..The rationale for the present study is to evaluate the importance of the surgical pathology in individuals undergoing epilepsy surgery...
  80. ncbi Assessment of 31P-NMR analysis of phospholipid profiles for potential differential diagnosis of human cerebral tumors
    Juan Solivera
    Department of Neurosurgery, Hospital Universitario Reina Sofia, Cordoba, Spain
    NMR Biomed 22:663-74. 2009
    ..a decrease in phosphatidylethanolamine (PtdEtn) and phosphatidylserine (PtdSer), the former mainly in neuroepithelial neoplasms and the latter in metastases...
  81. ncbi Papillary glioneuronal tumor
    R A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Pathol Lab Med 124:1820-3. 2000
    ..A MIB-1 labeling index of 1.1% was seen. p53 immunoreactivity was not observed. This report adds further evidence supporting the existence of this unusual mixed glioneuronal tumor of the central nervous system...
  82. ncbi Limited access inferior temporal gyrus approach to mesial basal temporal lobe tumors
    Juan S Uribe
    Department of Neurological Surgery, University of South Florida, Tampa, Florida, USA
    J Neurosurg 110:137-46. 2009
    ..A limited access approach to the inferior temporal gyrus (ITG) was used...
  83. ncbi From the archives of the AFIP: superficial gliomas: radiologic-pathologic correlation. Armed Forces Institute of Pathology
    K K Koeller
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, Bldg 54, Rm M 121, 14th St at Alaska Ave, Washington, DC 20306 6000, USA
    Radiographics 21:1533-56. 2001
    ..Both invoke an intense desmoplastic reaction, which appears as an enhancing soft-tissue component at imaging...
  84. ncbi ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development
    Roberta Sottocornola
    Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, UK
    Dev Cell 19:126-37. 2010
    ..These results identify ASPP2 as a regulator of Par-3, which plays a key role in controlling cell proliferation, polarity, and tissue organization during CNS development...
  85. ncbi Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo
    Fernanda Gonçalves de Andrade
    Department of Neurology and Neurosurgery, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Arq Neuropsiquiatr 67:626-32. 2009
    ..The aim was to analyze the characteristics of these tumors to determine the patients' overall survival and the likelihood of recurrence...
  86. ncbi Neuroectodermal ovarian tumors: a brief overview
    Anamarija Morovic
    Department of Pathology and Laboratory Medicine, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
    Histol Histopathol 23:765-71. 2008
    ..The clinical stage at the time of diagnosis is the most important prognostic parameter of these tumors...
  87. ncbi [On the best strategies on the best results for surgery of frontal epilepsy]
    S Trottier
    Service de Neurochirurgie, Hopital Sainte Anne, 1, rue Cabanis, 75014 Paris, France suzanne trottier fr
    Neurochirurgie 54:388-98. 2008
    ..Progress in electrophysiological and brain-imaging techniques will further improve the selection of frontal lobe epilepsy surgery candidates...
  88. ncbi Paraganglioma of the cauda equina presenting with erectile and sphincter dysfunction
    Wieslaw Marcol
    Department of Neurosurgery, Wojewodzki Szpital Specjalistyczny Nr 2, Jastrzebie Zdroj, Poland
    J Chin Med Assoc 72:328-31. 2009
    ..The patient underwent gross tumor resection, and the diagnosis of paraganglioma was based on neuropathologic examination. The symptoms completely resolved after tumor resection...
  89. ncbi Development of a pilocytic astrocytoma in a dysembryoplastic neuroepithelial tumor. Case report
    Vivek Josan
    Department of Neurosurgery, Royal Children s Hospital, Melbourne, Victoria, Australia
    J Neurosurg 106:509-12. 2007
    ..This paper adds to the growing body of literature about the biological behavior of these lesions...
  90. ncbi [Immunohistochemistry in oligodendrogliomas]
    Arlete Hilbig
    Clinica Medica, UFRGS, Brazil
    Arq Neuropsiquiatr 64:67-71. 2006
    ..Focal areas of neuronal differentiation can also be found in typical OL. The widespread staining with neuronal marker suggests central neurocytoma, but this diagnosis should not be done with small amount of tissue...
  91. ncbi Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor
    Ryoichi Sakuta
    Division of Pathology, The Hospital for Sick Children, University of Toronto, ON, Canada
    J Child Neurol 20:377-84. 2005
    ..Complete resection of a dysembryoplastic neuroepithelial tumor and its adjacent cortical dysplasia should be considered...
  92. ncbi [Role of epileptogenic lesions in the development of ictal and interictal epileptic disturbance]
    Jozsef Janszky
    Orv Hetil 143:915-20. 2002
    ..Conversely, malformations of cortical development have intrinsic epileptogenicity. In them, the seizure onset zone is localized intralesional: the lesion generates seizures itself...
  93. pmc Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortex
    Marjolein de Groot
    Department of Neurology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuro Oncol 12:265-73. 2010
    ..The distinct pattern of SV2A IR in glioneuronal tumors suggests a redistribution of SV2A...
  94. ncbi Chronic intractable epilepsy associated with a tumor located in the central region: functional mapping data and postoperative outcome
    B Devaux
    Department of Neurosurgery, Sainte Anne Hospital, Paris, France
    Stereotact Funct Neurosurg 69:229-38. 1997
    ....
  95. ncbi A case of melanotic desmoplastic ganglioglioma
    Manila Antonelli
    Departement of Pathology, University La Sapienza, Rome, Italy
    Neuropathology 29:597-601. 2009
    ..This case represents the first description of pigmented neoplastic cells in DIG, enlarging the spectrum of pigmented primary CNS tumors...
  96. ncbi Correlating velocity patterns with spatial dynamics in glioma cell migration
    Thomas S Deisboeck
    Complex Biosystems Modeling Laboratory, HST Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Acta Biotheor 53:181-90. 2005
    ..Implications of this finding for both experimental and clinical cancer research are discussed...
  97. ncbi Diagnostic value of minimum apparent diffusion coefficient values in prediction of neuroepithelial tumor grading
    Zhiye Chen
    Department of Radiology, PLA General Hospital, Beijing 100853, China
    J Magn Reson Imaging 31:1331-8. 2010
    ....
  98. ncbi A graft-versus-tumor effect in a patient with ependymoma who received an allogenic bone marrow transplant for therapy-related leukemia. Case report
    Minoru Tanaka
    Division of Neurosurgery, National Cancer Center Hospital, Tokyo, Japan
    J Neurosurg 97:474-6. 2002
    ..This case indicates that the graft-versus-tumor effect, mediated by cytotoxic T cells, may be able to target intraparenchymal neuroepithelial tumors, despite the brain's generally recognized status as an immunoprivileged organ...
  99. ncbi Astroblastoma. Case report, review of the literature, and analysis of treatment strategies
    F T Mangano
    Department of Pediatric Neurosurgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45267 0515, USA
    J Neurosurg Sci 51:21-7; discussion 27. 2007
    ..Continued clinical studies and longer patient follow-up with a tumor based registry would further clarify optimal treatment for this rare tumor...
  100. ncbi [A case of gliomatosis cerebri in an elderly woman]
    Y Komeno
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
    Nippon Ronen Igakkai Zasshi 38:540-3. 2001
    ..Open biopsy of the brain showed glioblastoma multiforme, which finally confirmed the clinical diagnosis of gliomatosis cerebri. We also review the classic and recent literatures...
  101. ncbi Fluid-attenuated inversion recovery ring sign as a marker of dysembryoplastic neuroepithelial tumors
    Hemant A Parmar
    Department of Diagnostic Imaging, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Comput Assist Tomogr 31:348-53. 2007
    ....

Research Grants6

  1. Academic Public Private Partnership Program
    M O DORISIO; Fiscal Year: 2004
    ..abstract_text> ..
  2. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
  3. Comparative DNA Microarray Analysis of Brain Tumors
    Daniel Brat; Fiscal Year: 2006
    ....
  4. Feasibility of Rehabilitation Robots and fMRI in Stroke
    A Tzika; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  5. Electrocorticographic Study of Categorical Phoneme Perception in the Human Tempor
    Edward Chang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..