Genomes and Genes
Summary: Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)
Publications230 found, 100 shown here
- [Dysembryoplastic neuroepithelial tumors]C Daumas-Duport
Laboratoire d Anatomie Pathologique, Hopital Sainte Anne, Paris
Rev Neurol (Paris) 159:622-36. 2003..DNTs should therefore be operated soon after diagnosis. However, excellent results can also be obtained by epilepsy surgery in patients with long term drug resistant partial seizures...
- Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridizationD J Brat
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Brain Pathol 10:342-52. 2000....
- Surgical management of temporal lobe tumor-related epilepsy in childrenOguz Cataltepe
Departments of Neurosurgery and Pediatric Neurology, Hacettepe University Medical School, Ankara, Turkey
J Neurosurg 102:280-7. 2005..In this study the authors review the clinical, pathological, and radiological features as well as outcome data obtained in 29 pediatric patients with temporal lobe tumor-related epilepsy and discuss the surgical treatment strategies...
- Papillary glioneuronal tumor--a new variant of benign mixed brain neoplasmRadzisław Kordek
Department of Pathology, Chair of Oncology, Medical University, Lodz
Pol J Pathol 54:75-8. 2003..From this point of view it is important to remember that such a wide spectrum may be difficult to discriminate into very narrow clinico-pathological entities...
- The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 casesCarla Fernandez
Department of Pathology and Neuropathology, Hopital d Enfants de la Timone, Marseille, France
AJNR Am J Neuroradiol 24:829-34. 2003..The goal of our study was to better characterize the clinical-radiologic-pathologic spectrum of DNTs (complex and simple forms only) in a series of 14 children...
- Nonmalignant pediatric brain tumorsMahmoud Rashidi
Division of Neurosurgery, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Curr Neurol Neurosci Rep 3:200-5. 2003..Advances in the therapeutic management of patients with these tumors have considerably improved their prognosis...
- A rare case of dysembryoplastic neuroepithelial tumour in occipital lobe presenting with only headacheHideo Hamada
Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
J Clin Neurosci 10:276-8. 2003..The lesion was totally resected and histopathologically diagnosed as DNT. Physicians must bear in mind that DNT may occur in the occipital lobe and present with only mass effect...
- [Dysembryoplastic neuroepithelial tumors in children]M J Muñoz-Muñoz
Rev Neurol 45:58-60. 2007
- A 52-year-old man with progressive left-sided weakness and white matter diseaseJohn O Fleming
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 44901, USA
Neurology 69:600-6. 2007
- Use of proton magnetic resonance spectroscopy of the brain to differentiate gliomatosis cerebri from low-grade gliomaDamien Galanaud
Centre de Resonance Magnetique Biologique et Medicale, Unite Mixte de Recherche, Centre National de Recherche Scientifique 6612, Faculte de Medecine, Universite de la Mediterranee, and Hôpital de La Timone, Marseille, France
J Neurosurg 98:269-76. 2003....
- Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowthJens Schittenhelm
Institute of Brain Research, University of Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
Neuropathology 27:383-9. 2007..Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed...
- Glioblastoma multiforme and ascending weaknessL J Cooke
Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Calgary, AB, Canada
Can J Neurol Sci 29:372-4. 2002
- The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumoursD F O'Brien
Department of Neurosurgery, Epilepsy Surgery Programme, Beaumont Hospital, Dublin, Ireland
Br J Neurosurg 21:539-49. 2007..It is not advocated to use a stereotactic biopsy only, as this may generate an unrepresentative tissue sample consisting of an oligodendroglial component only and may lead to an incorrect diagnosis...
- Various findings in surgically treated epilepsy patients with dysembryoplastic neuroepithelial tumors in comparison with those of patients with other low-grade brain tumors and other neuronal migration disordersRolf Degen
Epilepsy Centre Bethel, Bielefeld, Germany
Epilepsia 43:1379-84. 2002....
- Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case reportM Majores
Department of Neuropathology, University of Bonn Medical Center, Germany
Clin Neuropathol 26:311-6. 2007..We report on a 46-year-old male patient with pharmacoresistant temporal lobe epilepsy (TLE). Based on ictal EEG patterns and MRI scans, Ammon's horn sclerosis (AHS) or an epilepsy-associated tumor was included in the differential diagnosis...
- Chromosome 1p allelic loss by fluorescence in situ hybridization is not observed in dysembryoplastic neuroepithelial tumorsRichard A Prayson
Department of Neurological Surgery, Cleveland Clinic Foundation, OH 44195, USA
Am J Clin Pathol 118:512-7. 2002..LOH on chromosome 1p may be a useful differential diagnostic feature (favoring oligodendroglioma) in a subset of cases in which specimen fragmentation or size raises the differential diagnosis of DNT vs oligodendroglioma...
- Histological and MR correlations in Gliomatosis cerebriPaule Peretti-Viton
Department of Neuroradiology, Timone Hospital, Marseilles, France
J Neurooncol 59:249-59. 2002..Response to therapy could not clearly be observed in GC, despite oligodendroglial component in 6/9 cases. Prognosis of GC was constantly poor...
- Surgical strategies and seizure control in pediatric patients with dysembryoplastic neuroepithelial tumors: a single-institution experienceKrasimir Minkin
Department of Pediatric Neurosurgery, University Hospital La Timone, Marseille, France
J Neurosurg Pediatr 1:206-10. 2008..The authors present a study of long-term seizure outcome after noninvasive presurgical investigations and different surgical strategies were used in a series of pediatric patients...
- MRI of long-term epilepsy-associated tumorsHorst Urbach
Department of Radiology Neuroradiology, University of Bonn Medical Center, Bonn, Germany
Semin Ultrasound CT MR 29:40-6. 2008..This distinction is important since more than 70% of patients with drug resistant temporal lobe epilepsy caused by gangliogliomas and DNTs get seizure free following extended lesionectomy...
- Malignant astroblastoma with rhabdoid morphologySerguei I Bannykh
8700 Beverly Blvd, Los Angeles, CA 90048, USA
J Neurooncol 83:277-8. 2007
- Neuroradiologic characteristics of astroblastomaJohn W Bell
Department of Radiology, University of Utah, 50 North Medical Drive, Salt Lake City, UT, 84132, USA
Neuroradiology 49:203-9. 2007..We report the largest imaging series to date and further delineate the CT and MRI features of astroblastoma. We identify those features that may be useful in distinguishing astroblastoma from other neoplasms...
- Seizure outcome of lesionectomy in glioneuronal tumors associated with epilepsy in childrenMarco Giulioni
Department of Neurosciences, Bellaria Hospital, Bologna, Italy
J Neurosurg 102:288-93. 2005..To address this uncertainty, the authors analyzed seizure outcome in a series of children with epileptogenic glioneuronal tumors that had been treated only by lesionectomy...
- Clinical diagnosis of gliomatosis cerebri: report of three casesJiro Akimoto
Department of Neurosurgery and Pathology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Brain Tumor Pathol 21:87-95. 2004..Diagnosis of GC should be faithful to the pathological diagnosis criteria of Scheinker and Evans, and therefore the precise assessment of MRI findings according to these criteria is required for clinical, antemortem diagnosis of GC...
- Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasionT Suzuki
Department of Neurosurgery, Osaka University Medical School, 2 2, Yamadaoka, Suita, Osaka, 565 0871, Japan
J Clin Pathol 58:166-71. 2005..Because the nosological definition and histogenesis of GC remain controversial, the morphology and immunohistochemical staining patterns of neoplastic GC cells were compared with those of other gliomas...
- Multifocal dysembryoplastic neuroepithelial tumour in a male with the XYY syndromeB K Krossnes
Neuropathol Appl Neurobiol 31:556-60. 2005
- Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsyS Vogelgesang
Department of Neuropathology, University of Greifswald, Germany
Clin Neuropathol 23:223-31. 2004..There is mounting evidence that multidrug transporters such as P-glycoprotein (P-gp) or multidrug resistance-associated proteins (MRP) play an important role in the development of resistance to antiepileptic drugs (AED)...
- Astroblastoma: a case reportDong Sug Kim
Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea
J Korean Med Sci 19:772-6. 2004..2, while showing negativity for synaptophysin, neurofilament protein, pan-cytokeratin and high molecular weight keratin...
- [11C]-Methionine PET: dysembryoplastic neuroepithelial tumours compared with other epileptogenic brain neoplasmsD S Rosenberg
CERMEP, Hopital Neurologique, 59 Bd Pinel, Lyon 69003, France
J Neurol Neurosurg Psychiatry 76:1686-92. 2005..This study tested whether [(11)C]-methionine positron emission tomography (MET-PET) could help to distinguish DNTs from other epileptogenic brain tumours...
- Initial chemotherapy in gliomatosis cerebriM Sanson
Fédération de Neurologie Mazarin, Groupe hospitalier Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France
Neurology 63:270-5. 2004..Because of the diffuse nature of gliomatosis cerebri (GC), surgery is not suitable, and large field radiotherapy carries the risk of severe toxicity. In this setting, initial chemotherapy warrants further investigation...
- Gliomatosis cerebri: better definition, better treatmentMarc C Chamberlain
Neurology 63:204-5. 2004
- Gliomatosis cerebri may present as an atypical parkinsonian syndromeEric S Molho
Albany Medical College, Department of Neurology, Albany, New York, USA
Mov Disord 19:341-4. 2004..The patient died 4 years after the onset of symptoms. Pathological examination revealed diffuse infiltration of multiple brain regions with cells of astrocytic and microglial origin consistent with a diagnosis of gliomatosis cerebri...
- Parkinsonism and dementia due to gliomatosis cerebri mimicking sporadic Creutzfeldt-Jakob disease (CJD)M Slee
J Neurol Neurosurg Psychiatry 77:283-4. 2006
- Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiationToshihiko Kubota
Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, Yoshida gun, Fukui, Japan
Neuropathology 26:72-81. 2006..Numerous microvilli protruded and basal lamina abutted on the tumor cell surface. We report these unique histological features, and stress that astroblastoma should be categorized as a specific type of neuroepithelial tumor...
- [Gliomatosis cerebri: report of 3 cases and review of recent literatures]Masayuki Arai
Department of Neurosurgery, Fukui Prefectural Hospital, Yotsui 2 8 1, Fukui City 910 8526, Japan
No To Shinkei 55:890-7. 2003..Case 3 improved in response to radiotherapy and chemotherapy using procarbazine/MCNU/vincristine (MVP). We also reviewed recent literatures...
- Clinical features and epileptogenesis of dysembryoplastic neuroepithelial tumorMin Cheol Lee
Department of Pathology, Chonnam National University Medical School and Hospital, 5 Hakdong, Dongku, Gwangju, 501 746, South Korea
Childs Nerv Syst 22:1611-8. 2006..Dysembryoplastic neuroepithelial tumor (DNT) frequently causes medically intractable epilepsy...
- Gliomatosis cerebri: 20 years of experience at the Children's Hospital of PhiladelphiaGregory T Armstrong
Division of Oncology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Cancer 107:1597-606. 2006..In this report, the authors describe the largest cohort of children to date with GC and explore relations between potential prognostic factors, treatment, and survival...
- Expression of CD34 as a novel marker for glioneuronal lesions associated with chronic intractable epilepsyP Deb
Department of Pathology, All India Institute of Medical Sciences AIIMS, New Delhi, India
Neuropathol Appl Neurobiol 32:461-8. 2006....
- CD9 expression in solid non-neuroepithelial tumors and infiltrative astrocytic tumorsMasatou Kawashima
Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Histochem Cytochem 50:1195-203. 2002..This might be explained by the observation that the CD9 molecule is associated with a mitogenic factor, membrane-anchored heparin-binding epidermal growth factor, which is known to be upregulated in malignant gliomas...
- Gliomatosis of the brain and spinal cord masquerading as infective lesionsGeorge Meligonis
Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa
Surg Neurol 57:399-404; discussion 404. 2002..The clinico-pathological problems and difficulties in the ante-mortem diagnosis as well as the clinical and pathological similarities to infective lesions are evaluated...
- Central nervous system medulloepithelioma: a series of eight cases including two arising in the ponsP T Molloy
Department of Pathology, The Children s Hospital of Philadelphia, Department of Pathology, The Children s Hospital of Philadelphia Pennsylvania, USA
J Neurosurg 84:430-6. 1996..Medulloepithelioma, often confused with less aggressive PNETs, can mimic intrinsic brainstem glioma, responds poorly to treatment, and is prone to CNS dissemination at the time of tumor progression...
- Gliomatosis cerebri: pitfalls in diagnosisP Rust
Department of Neurosurgery, Atkinson Morley's Hospital, London, UK
J Clin Neurosci 8:361-3. 2001..Magnetic resonance imaging was required to show the lesions with greater definition; however, in both cases, a biopsy was needed to confirm the diagnosis...
- Gliomatosis cerebri in a 10-year-old girl masquerading as diffuse encephalomyelitis and spinal cord tumourS Jayawant
Department of Paediatric Neurology, University Hospital of Wales, Heath Park, Cardiff, UK
Dev Med Child Neurol 43:124-6. 2001..A diffuse encephalomyelopathy occurred, which was complicated by spinal cord swelling, followed by deterioration and death. Gliomatosis cerebri affecting the brain and spinal cord was found at postmortem examination...
- Astroblastoma: radiologic-pathologic correlation and distinction from ependymomaJohn D Port
Neuroradiology Division, Johns Hopkins Hospital, Baltimore, MD, USA
AJNR Am J Neuroradiol 23:243-7. 2002..The solid component of the mass has a bubbly appearance and a T2 signal that is isointense to gray matter. Punctate calcifications are often present. Neuroradiologists should be familiar with the characteristic appearance of this tumor...
- Gliomatosis cerebriStuart S Kaplan
Department of Neurological Surgery, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
Pediatr Neurosurg 36:111-2. 2002
- Dysembryoplastic neuroepithelial tumors in childhood: long-term outcome and prognostic featuresM A Nolan
Brain and Behavior Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada
Neurology 62:2270-6. 2004..The authors describe the clinical, radiologic, and pathologic characteristics and outcomes in children after surgical resection of pathologically confirmed DNT to ascertain prognostic features for seizure recurrence following surgery...
- Combined positron emission tomography and magnetic resonance imaging for the planning of stereotactic brain biopsies in children: experience in 9 casesBenoit Pirotte
Department of Neurosurgery, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
Pediatr Neurosurg 38:146-55. 2003....
- [Seizures and recurrent left hemiparesia (clinical conference)]K Hoang-Xuan
Fédération de Neurologie Mazarin, Groupe Hospitalier Pitie Salpetriere, Paris, France
Rev Neurol (Paris) 158:369-76. 2002
- [Case no 1. Neuroepithelial dysembryoplastic tumor]F Brami-Zylberberg
Département d imagerie Morphologique et Fonctionelle, Centre Hospitalier Sainte Anne, Paris
J Radiol 84:78-9. 2003
- Telomerase activity and alterations in telomere length in human brain tumorsS Hiraga
Department of Neurosurgery, Osaka University Medical School, Suita, Japan
Cancer Res 58:2117-25. 1998..These findings suggest that telomerase activity can be an index of malignant potential or malignancy itself in nonneuroepithelial brain tumors...
- Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptorE Aronica
Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Acta Neuropathol 101:383-92. 2001..In addition, since these neurons contain both NMDAR1 and NMDAR2A/B subunits, the BDNF-TrkB pathway may also contribute through a modulation of glutamatergic transmission to the intrinsic epileptogenicity of glioneuronal tumors...
- [Supratentorial tumors]I Grunwald
Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitatsklinikum des Saarlandes, Homburg
Radiologe 47:471-85. 2007..The supratentorial extracranial tumors include the choroid plexus, colloid cysts, meningeoma, infantile myofibromatosis and lipoma. The most common sub-forms, especially of astrocytoma, will also be presented...
- Allelic losses in oligodendroglial and oligodendroglioma-like neoplasms: analysis using microsatellite repeats and polymerase chain reactionMahlon D Johnson
Department of Pathology, Vanderbilt Medical School, Nashville, Tenn 37232, USA
Arch Pathol Lab Med 127:1573-9. 2003..Oligodendroglial tumors are heterogenous neoplasms with histologic features shared with other central nervous system tumors, such as dysembryoplastic neuroepithelial tumors...
- Coexistent pathology in chronic epilepsy patients with neoplasmsRichard A Prayson
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Mod Pathol 23:1097-103. 2010..Coexistent pathology may account for the incidence of recurrent or residual epilepsy in patients who undergo tumor resection...
- Differential telomerase expression and telomere length in primary intracranial tumorsH J Chen
Department of Neurosurgery, Chang Gung Memorial Hospital, 123, Tao Pei Road, Niaosung, Kaohsiung, Taiwan, R O C
Chang Gung Med J 24:352-60. 2001..The authors examined telomerase activity and telomere length in intracranial tumors to determine the clinicopathological behavior of primary intracranial tumors with respect to telomerase expression and alteration of telomere length...
- Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adultsAnna Taraszewska
Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
Folia Neuropathol 43:172-7. 2005..To our knowledge, this is the first reported case of pigmented pilocytic astrocytoma exhibiting extensive intracellular hemosiderin deposition...
- Drug-resistance gene expression and progression of astrocytic tumorsS Tanaka
Department of Neurosurgery, Kitasato Institute Medical Center Hospital, Kitamoto, Saitama, Japan
Brain Tumor Pathol 18:131-7. 2001..These findings suggest that native drug resistance is more important than acquired resistance when glioma therapy is considered...
- Rosette-forming glioneuronal tumor: pathology case reportJosé Pimentel
Department of Neurology, Laboratory of Neuropathology, Institute of Molecular Medicine, Hospital de Santa Maria, Lisbon Faculty of Medicine, Lisbon, Portugal
Neurosurgery 62:E1162-3; discussion E1163. 2008..Rosette-forming glioneuronal tumor is a newly described mixed glial and neuronal tumor. We describe two cases and review the literature to better characterize this entity...
- Cytogenetic characterizations of central nervous system tumors: the first comprehensive report from a single institution in KoreaKyung Eun Kim
Department of Laboratory Medicine, Dong A University College of Medicine, Busan, Korea
J Korean Med Sci 24:453-60. 2009..More detailed cytogenetic and molecular characterizations of CNS tumors contribute to better diagnostic criteria and deeper insights of tumorigenesis, eventually resulting in development of novel therapeutic strategies...
- Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivityToshio Uesaka
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Neurooncol 84:119-29. 2007..Based on these observations, Topo IIalpha and beta mRNA expression, but not the Topo IIalpha labeling index, might be a useful marker for sensitivity to etoposide in human malignant neuroepithelial tumors...
- Immunohistochemistry of primary malignant neuroepithelial tumors of the kidney: a potential source of confusion? A study of 30 cases from the National Wilms Tumor Study Pathology CenterDale A Ellison
Department of Pathology, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
Hum Pathol 38:205-11. 2007..We recommend molecular fusion studies for clarification of primitive renal tumors with unexpected immunophenotypic results...
- Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survivalJens Schittenhelm
Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
Mod Pathol 22:1600-11. 2009..Thus, annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof...
- PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial TumorsElisabetta Benedetti
Department of Basic and Applied Biology, University of L Aquila, 67100 L Aquila, Italy
PPAR Res 2010:427401. 2010..This review will focus on the major studies dealing with PPAR expression in gliomas and neuroblastoma and the therapeutic implications of using PPAR agonists for the treatment of these neoplasms...
- Giant cell ependymoma: a case reportDariusz Adamek
Department of Neuropathology, Medical College, Jagiellonian University, 3 Botaniczna St, 31 503 Krakow, Poland
Clin Neurol Neurosurg 110:176-81. 2008..To the best of our knowledge this is the 8th case in the literature. In spite of apparently "worrisome" histology GCE seems to be a neoplasm with a relatively good prognosis...
- Clinical epidemiology for childhood primary central nervous system tumorsLuc Bauchet
Department of Neurosurgery, Centre Hospitalo Universitaire, Hopital Gui de Chauliac, 80 avenue Augustin Fliche, 34 295, Montpellier Cedex 5, France
J Neurooncol 92:87-98. 2009....
- The differential diagnosis of central nervous system tumors: a critical examination of some recent immunohistochemical applicationsMark A Edgar
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
Arch Pathol Lab Med 132:500-9. 2008..These will be used for purposes of tumor subclassification, as prognostic markers, as identifiers of potential therapeutic targets, and as predictors of treatment response...
- Pineal tumorsSonika Dahiya
Department of Pathology, Washington University School of Medicine, St Louis, MO, USA
Adv Anat Pathol 17:419-27. 2010....
- Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas?Tanja Kuhlmann
Institute of Neuropathology, University Hospital Munster, Munster, Germany
Am J Surg Pathol 32:1444-53. 2008..They also support the hypothesis that GBM may be a heterogeneous group of tumors derived from different progenitor cells...
- Schinzel-Giedion syndrome: report of splenopancreatic fusion and proposed diagnostic criteriaAnna M Lehman
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Am J Med Genet A 146:1299-306. 2008..Other highly supportive features include neuroepithelial tumors (found in 17%), hypertrichosis, and brain abnormalities. Severe developmental delay and poor survival are constant features in reported patients...
- Focal cortical dysplasia type II (malformations of cortical development) aberrantly expresses apoptotic proteinsWendy A Chamberlain
Department of Pathology and Laboratory Medicine, Neuropathology Section, Cleveland Clinic, Cleveland, OH 44195, USA
Appl Immunohistochem Mol Morphol 16:471-6. 2008....
- Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomasStefan Pfister
Division Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Genes Chromosomes Cancer 46:839-51. 2007..02) were confirmed to be more frequent in medulloblastomas. These data further support the hypothesis of two different tumor entities of embryonal neuroepithelial tumors with characteristic genetic aberrations. (c) 2007 Wiley-Liss, Inc...
- Primary cerebral neuroblastoma: a case report and reviewVolkan Etus
Kocaeli University Medical School, Department of Neurosurgery, Derince, Turkey
Tohoku J Exp Med 197:55-65. 2002..A 9-year-old girl with primary cerebral neuroblastoma who was initially misdiagnosed is reported. The other cases from the literature are reviewed and the nature of this rare tumor and its differential diagnosis is discussed...
- Electron microscopy in an oncologic institution. Diagnostic usefulness in surgical pathologyL Lombardi
Division of Experimental Oncology A, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italia
Tumori 74:531-5. 1988..In cases of well-differentiated neuroepithelial tumors, such as carcinoids, EM data was essentially confirmatory of (immuno)-histochemical findings...
- "Ex vivo" release of eicosanoid from human brain tissue: its relevance in the development of brain edemaP Gaetani
Department of Surgery, IRCCS Policlinico S Matteo, Italy
Neurosurgery 28:853-7; discussion 857-8. 1991..56 +/- 0.91). The capacity to synthesize prostacyclin is significantly higher in patients with brain metastasis than in those with neuroepithelial tumors and meningiomas (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)..
- Abdominal epilepsy and foreign body in the abdomen--dilemma in diagnosis of abdominal painNoor Topno
Department of General Surgery, Kasturba Medical College and Hospital, Manipal 576 119, Karnataka State, India
Yonsei Med J 46:870-3. 2005..On detailed analysis of her medical history and after appropriate investigations, she was diagnosed with temporal lobe epilepsy which was treated with appropriate medications, and which resulted in her pain being relieved...
- Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimicsArie Perry
Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Front Biosci 8:a1-9. 2003....
- Intracranial ependymoma: factors affecting outcomeMaura Massimino
Division of Pediatric Oncology, Istituto Nazionale dei Tumori, Milan, Italy
Future Oncol 5:207-16. 2009..For high-risk patients, with residual tumor, an interesting, although experimental, approach could be chemotherapy followed by secondary surgery and postoperative conformal irradiation...
- Molecular genetic changes in a series of neuroepithelial tumors of childhoodAlessia Di Sapio
Divisione Universitaria di Neurologia, Ospedale San Luigi, Torino, Italy
J Neurooncol 59:117-22. 2002....
- [Clinicopathologic and radiologic features of dysembryoplastic neuroepithelial tumors]Fu Lin Wang
Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China
Zhonghua Bing Li Xue Za Zhi 34:566-8. 2005..To study the clinicopathologic features and radiologic findings of dysembryoplastic neuroepithelial tumor (DNT)...
- Psychiatric co-morbidity in 75 patients undergoing epilepsy surgery: lack of correlation with pathological findingsA M Siegel
Division of Epilepsy, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Epilepsy Res 80:158-62. 2008..The rationale for the present study is to evaluate the importance of the surgical pathology in individuals undergoing epilepsy surgery...
- Assessment of 31P-NMR analysis of phospholipid profiles for potential differential diagnosis of human cerebral tumorsJuan Solivera
Department of Neurosurgery, Hospital Universitario Reina Sofia, Cordoba, Spain
NMR Biomed 22:663-74. 2009..a decrease in phosphatidylethanolamine (PtdEtn) and phosphatidylserine (PtdSer), the former mainly in neuroepithelial neoplasms and the latter in metastases...
- Papillary glioneuronal tumorR A Prayson
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Arch Pathol Lab Med 124:1820-3. 2000..A MIB-1 labeling index of 1.1% was seen. p53 immunoreactivity was not observed. This report adds further evidence supporting the existence of this unusual mixed glioneuronal tumor of the central nervous system...
- Limited access inferior temporal gyrus approach to mesial basal temporal lobe tumorsJuan S Uribe
Department of Neurological Surgery, University of South Florida, Tampa, Florida, USA
J Neurosurg 110:137-46. 2009..A limited access approach to the inferior temporal gyrus (ITG) was used...
- From the archives of the AFIP: superficial gliomas: radiologic-pathologic correlation. Armed Forces Institute of PathologyK K Koeller
Department of Radiologic Pathology, Armed Forces Institute of Pathology, Bldg 54, Rm M 121, 14th St at Alaska Ave, Washington, DC 20306 6000, USA
Radiographics 21:1533-56. 2001..Both invoke an intense desmoplastic reaction, which appears as an enhancing soft-tissue component at imaging...
- ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS developmentRoberta Sottocornola
Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Headington, Oxford OX3 7DQ, UK
Dev Cell 19:126-37. 2010..These results identify ASPP2 as a regulator of Par-3, which plays a key role in controlling cell proliferation, polarity, and tissue organization during CNS development...
- Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São PauloFernanda Gonçalves de Andrade
Department of Neurology and Neurosurgery, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Arq Neuropsiquiatr 67:626-32. 2009..The aim was to analyze the characteristics of these tumors to determine the patients' overall survival and the likelihood of recurrence...
- Neuroectodermal ovarian tumors: a brief overviewAnamarija Morovic
Department of Pathology and Laboratory Medicine, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
Histol Histopathol 23:765-71. 2008..The clinical stage at the time of diagnosis is the most important prognostic parameter of these tumors...
- [On the best strategies on the best results for surgery of frontal epilepsy]S Trottier
Service de Neurochirurgie, Hopital Sainte Anne, 1, rue Cabanis, 75014 Paris, France suzanne trottier fr
Neurochirurgie 54:388-98. 2008..Progress in electrophysiological and brain-imaging techniques will further improve the selection of frontal lobe epilepsy surgery candidates...
- Paraganglioma of the cauda equina presenting with erectile and sphincter dysfunctionWieslaw Marcol
Department of Neurosurgery, Wojewodzki Szpital Specjalistyczny Nr 2, Jastrzebie Zdroj, Poland
J Chin Med Assoc 72:328-31. 2009..The patient underwent gross tumor resection, and the diagnosis of paraganglioma was based on neuropathologic examination. The symptoms completely resolved after tumor resection...
- Development of a pilocytic astrocytoma in a dysembryoplastic neuroepithelial tumor. Case reportVivek Josan
Department of Neurosurgery, Royal Children s Hospital, Melbourne, Victoria, Australia
J Neurosurg 106:509-12. 2007..This paper adds to the growing body of literature about the biological behavior of these lesions...
- [Immunohistochemistry in oligodendrogliomas]Arlete Hilbig
Clinica Medica, UFRGS, Brazil
Arq Neuropsiquiatr 64:67-71. 2006..Focal areas of neuronal differentiation can also be found in typical OL. The widespread staining with neuronal marker suggests central neurocytoma, but this diagnosis should not be done with small amount of tissue...
- Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumorRyoichi Sakuta
Division of Pathology, The Hospital for Sick Children, University of Toronto, ON, Canada
J Child Neurol 20:377-84. 2005..Complete resection of a dysembryoplastic neuroepithelial tumor and its adjacent cortical dysplasia should be considered...
- [Role of epileptogenic lesions in the development of ictal and interictal epileptic disturbance]Jozsef Janszky
Orv Hetil 143:915-20. 2002..Conversely, malformations of cortical development have intrinsic epileptogenicity. In them, the seizure onset zone is localized intralesional: the lesion generates seizures itself...
- Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortexMarjolein de Groot
Department of Neurology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Neuro Oncol 12:265-73. 2010..The distinct pattern of SV2A IR in glioneuronal tumors suggests a redistribution of SV2A...
- Chronic intractable epilepsy associated with a tumor located in the central region: functional mapping data and postoperative outcomeB Devaux
Department of Neurosurgery, Sainte Anne Hospital, Paris, France
Stereotact Funct Neurosurg 69:229-38. 1997....
- A case of melanotic desmoplastic gangliogliomaManila Antonelli
Departement of Pathology, University La Sapienza, Rome, Italy
Neuropathology 29:597-601. 2009..This case represents the first description of pigmented neoplastic cells in DIG, enlarging the spectrum of pigmented primary CNS tumors...
- Correlating velocity patterns with spatial dynamics in glioma cell migrationThomas S Deisboeck
Complex Biosystems Modeling Laboratory, HST Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Acta Biotheor 53:181-90. 2005..Implications of this finding for both experimental and clinical cancer research are discussed...
- Diagnostic value of minimum apparent diffusion coefficient values in prediction of neuroepithelial tumor gradingZhiye Chen
Department of Radiology, PLA General Hospital, Beijing 100853, China
J Magn Reson Imaging 31:1331-8. 2010....
- A graft-versus-tumor effect in a patient with ependymoma who received an allogenic bone marrow transplant for therapy-related leukemia. Case reportMinoru Tanaka
Division of Neurosurgery, National Cancer Center Hospital, Tokyo, Japan
J Neurosurg 97:474-6. 2002..This case indicates that the graft-versus-tumor effect, mediated by cytotoxic T cells, may be able to target intraparenchymal neuroepithelial tumors, despite the brain's generally recognized status as an immunoprivileged organ...
- Astroblastoma. Case report, review of the literature, and analysis of treatment strategiesF T Mangano
Department of Pediatric Neurosurgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45267 0515, USA
J Neurosurg Sci 51:21-7; discussion 27. 2007..Continued clinical studies and longer patient follow-up with a tumor based registry would further clarify optimal treatment for this rare tumor...
- [A case of gliomatosis cerebri in an elderly woman]Y Komeno
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
Nippon Ronen Igakkai Zasshi 38:540-3. 2001..Open biopsy of the brain showed glioblastoma multiforme, which finally confirmed the clinical diagnosis of gliomatosis cerebri. We also review the classic and recent literatures...
- Fluid-attenuated inversion recovery ring sign as a marker of dysembryoplastic neuroepithelial tumorsHemant A Parmar
Department of Diagnostic Imaging, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
J Comput Assist Tomogr 31:348-53. 2007....
- Academic Public Private Partnership ProgramM O DORISIO; Fiscal Year: 2004..abstract_text> ..
- Intravascular Thrombosis in GlioblastomaDaniel Brat; Fiscal Year: 2005..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
- Comparative DNA Microarray Analysis of Brain TumorsDaniel Brat; Fiscal Year: 2006....
- Feasibility of Rehabilitation Robots and fMRI in StrokeA Tzika; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Electrocorticographic Study of Categorical Phoneme Perception in the Human TemporEdward Chang; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.Daniel J Brat; Fiscal Year: 2010..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..