Genomes and Genes
Summary: Excessive slowness in the action of the heart, usually with a heart rate below 60 beats per minute.
Publications355 found, 100 shown here
- Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafnessShahid M Baig
Human Molecular Genetics Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
Nat Neurosci 14:77-84. 2011..We describe a human channelopathy (termed SANDD syndrome, sinoatrial node dysfunction and deafness) with a cardiac and auditory phenotype that closely resembles that of Cacna1d(-/-) mice...
- Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflexS M Kinsella
Sir Humphry Davy Department of Anaesthesia, St Michael's Hospital, Bristol, UK
Br J Anaesth 86:859-68. 2001Reflex cardiovascular depression with vasodilation and bradycardia has been variously termed vasovagal syncope, the Bezold-Jarisch reflex and neurocardiogenic syncope...
- Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic micePeiyong Zhai
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
J Clin Invest 115:3045-56. 2005..Tg-i2m mice developed more severe cardiac hypertrophy and bradycardia coupled with lower cardiac function than Tg-WT mice...
- Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptorsJohn T Fisher
Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
FASEB J 18:711-3. 2004..ligands, have complicated the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due to vagal innervation...
- Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 familiesMarieke W Veldkamp
Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
Circ Res 92:976-83. 2003..In addition to the characteristic QT prolongation, LQT3 carriers regularly present with bradycardia and sinus pauses...
- Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patientsA V Postma
J Med Genet 42:863-70. 2005..The aim of the study was to assess underlying genetic cause(s), clinical features, and response to therapy in catecholaminergic polymorphic ventricular tachycardia (CPVT) probands...
- Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakersAlessandro Capucci
Cardiology Department, Civile Hospital, Piacenza, Italy
J Am Coll Cardiol 46:1913-20. 2005The aim of our study was to evaluate arterial embolism (AE) occurrence rates and predictors in patients suffering from bradycardia and wearing a pacemaker with antitachycardia pacing therapies.
- Pediatric rapid sequence intubation: incidence of reflex bradycardia and effects of pretreatment with atropineRebecca K Fastle
Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center and The Children s Hospital, Denver, CO, USA
Pediatr Emerg Care 20:651-5. 2004The American College of Emergency Physicians (ACEP) recommends atropine as adjunctive therapy to prevent reflex bradycardia prior to laryngoscopy/tracheal intubation (L/TI) in pediatric patients.
- Bradycardia during critical care intubation: mechanisms, significance and atropinePeter Jones
Critical Care Group Portex Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
Arch Dis Child 97:139-44. 2012b>Bradycardia occurs during the intubation of some critically ill children as a result of vagal stimulation due to hypoxia and/or laryngeal stimulation; such 'stable' bradycardia is accompanied by selective vasoconstriction...
- The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in ratRyan M Fryer
Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, United States of America
PLoS ONE 7:e52985. 2012..S1P(X) receptor agonist) produces modest hypertension in patients (2-3 mmHg in 1-yr trial) as well as acute bradycardia independent of changes in blood pressure...
- Cholinesterase inhibitors and incidence of bradycardia in patients with dementia in the veterans affairs new England healthcare systemRohini K Hernandez
Cooperative Studies Program, Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
J Am Geriatr Soc 57:1997-2003. 2009To quantify the association between cholinesterase inhibitors (ChE-Is) and a new diagnosis of bradycardia and to evaluate the clinical significance of bradycardia.
- Prolonged and symptomatic bradycardia following a single dose of fingolimodHans Faber
Neurology, Max Planck Institute of Psychiatry, Munich, Germany
Mult Scler 19:126-8. 2013Fingolimod-related bradycardia is usually asymptomatic, reaches its nadir within 6 hours post-dose and recovers spontaneously...
- Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardiaAtsunori Kamiya
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1 Hujishirodai, Suita, Osaka 565 8565, Japan
Am J Physiol Heart Circ Physiol 289:H1758-69. 2005..LF oscillation of MSNA variability decreased during development of orthostatic neurally mediated syncope, preceding sympathetic withdrawal, bradycardia, and severe hypotension, to the level at syncope.
- Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardiaYongxia Qu
VA New York Harbor Healthcare System, New York, NY, USA
Circulation 111:3034-41. 2005..Although the hallmark of CHB is complete atrioventricular block, sinus bradycardia has been reported recently in animal models of CHB...
- Mechanism of syncope in patients with isolated syncope and in patients with tilt-positive syncopeA Moya
Departments of Cardiology of Hospital Vall d'Hebron, Barcelona, Spain
Circulation 104:1261-7. 2001..one or more prolonged asystolic pauses, mainly due to sinus arrest, preceded for a few minutes by progressive bradycardia or progressive tachycardia-bradycardia...
- Atropine for critical care intubation in a cohort of 264 children and reduced mortality unrelated to effects on bradycardiaPeter Jones
Critical Care Group Portex Unit, Institute of Child Health, University College London, London, Great Britain
PLoS ONE 8:e57478. 2013..Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality...
- Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking developmentRudiger J Blaschke
Human Genetics, University of Heidelberg, Heidelberg, Germany
Circulation 115:1830-8. 2007..Here, we report on a highly restricted expression pattern of the homeodomain transcription factor Shox2 in the sinus venosus myocardium, including the sinoatrial nodal region and the venous valves...
- Treatment of persistent sinus bradycardia with intermittent symptoms: are guidelines clear?Paolo Alboni
Division of Cardiology, Arrhythmologic Center, Ospedale Civile di Cento, 44042 Cento FE, Italy
Europace 11:562-4. 2009There is uncertainty in the aetiology of syncope in subjects with persistent sinus bradycardia (SB) (sick sinus syndrome)...
- Role of pulmonary stretch receptors and sympathetic system in the inhibition of reflex bradycardia produced by chemical stimulation of the periaqueductal gray matter of the ratK N Sampaio
Department of Pharmaceutical Sciences, Health Science Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
Neuroscience 210:222-33. 2012..The baroreflex bradycardia was induced by phenylephrine infusions (PHE, 50 μg/ml/min, i.v...
- The development of diving bradycardia in bottlenose dolphins (Tursiops truncatus)S R Noren
Ecology and Evolutionary Biology Department, Center for Ocean Health, University of California, Santa Cruz, CA 95060, USA
J Comp Physiol B 174:139-47. 2004b>Bradycardia is an important component of the dive response, yet little is known about this response in immature marine mammals...
- Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathwayNeil Herring
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford University OX1 3PT, UK
J Mol Cell Cardiol 44:477-85. 2008..Y (NPY), released during prolonged cardiac sympathetic nerve stimulation, can attenuate vagal-induced bradycardia. We tested the hypothesis that NPY reduces acetylcholine release, at similar concentrations to which it ..
- Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changesYukiomi Tsuji
Research Center, Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
Circulation 113:345-55. 2006..Uncontrolled tachycardia produces heart failure and ventricular tachyarrhythmia susceptibility, whereas bradycardia promotes spontaneous torsade de pointes (TdP)...
- Bradycardia leading to asystole during dexmedetomidine infusion in an 18 year-old double-lung transplant recipientXiaopeng Zhang
Division of Anesthesiology, Geisinger Medical Center, Danville, PA 17821, USA
J Clin Anesth 22:45-9. 2010..transplant recipient recovering from acute respiratory distress syndrome who developed repeated episodes of bradycardia and asystole (maximum duration: 10 sec) during dexmedetomidine administration is presented...
- Hypotension, bradycardia and syncope caused by honey poisoningOzcan Yilmaz
Ondokuz Mayis University School of Medicine, Department of Cardiology, Kurupelit, Samsun, Turkey
Resuscitation 68:405-8. 2006..with a variety of symptoms including nausea, vomiting, salivation, dizziness, weakness, hypotension, bradycardia and syncope several hours after the ingestion of small amounts of honey...
- Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardiaLuiza Michelle Cangussu
Departamento de Ciencias Biologicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil
Peptides 30:1921-7. 2009..and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C)...
- Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibitionBoyoung Joung
Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University Schoolof Medicine, Indianapolis, Indiana 46202, USA
Am J Physiol Heart Circ Physiol 299:H634-42. 2010..Combined malfunction of both membrane and Ca(2+) clocks underlies the mechanisms of PSPs...
- Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4Mirko Baruscotti
Department of Biomolecular Sciences and Biotechnology, PaceLab and Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata, Milano, Universita degli Studi di Milano, 20133 Milan, Italy
Proc Natl Acad Sci U S A 108:1705-10. 2011..HCN4 knockout (ciHCN4-KO) mouse model, ablation of HCN4 consistently leads to progressive development of severe bradycardia (∼50% reduction of original rate) and AV block, eventually leading to heart arrest and death in about 5 d...
- Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channelsMatteo E Mangoni
Institut de Genomique Fonctionnelle, CNRS UMR5203 INSERM U661, Departement de Physiologie, Universite de Montpellier I, Montpellier Cedex 05, F 34094, France
Circ Res 98:1422-30. 2006..electrocardiograms on unrestrained mice and intracardiac recordings, we find that cacna1g inactivation causes bradycardia and delays atrioventricular conduction without affecting the excitability of the right atrium...
- The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndromeXiaoyan Qi
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Circ Arrhythm Electrophysiol 2:295-304. 2009Sustained bradycardia is associated with long-QT syndrome in human beings and causes spontaneous torsades de pointes in rabbits with chronic atrioventricular block (CAVB), at least partly by downregulating delayed-rectifier K(+)-current ..
- Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 womenA Brucato
Niguarda Hospital, Milan, Italy
Arthritis Rheum 44:1832-5. 2001..In 2 centers, electrocardiography was recorded in 24 unselected newborns, and 4 were found to have sinus bradycardia. CONCLUSION: The prevalence of CCHB in newborns of prospectively followed up women already known to be anti-Ro/..
- Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA releaseT Kishi
Department of Cardiovascular Medicine, Cardiovascular Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hypertension 38:896-901. 2001..Furthermore, these responses may be mediated by an increased release of GABA in the RVLM...
- A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan JewsAvishag Laish-Farkash
Heart Institute, Sheba Medical Center, Tel Hashomer, Israel Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Cardiovasc Electrophysiol 21:1365-72. 2010to conduct a clinical, genetic, and functional analysis of 3 unrelated families with familial sinus bradycardia (FSB).
- Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinibSai Hong Ignatius Ou
Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, California 92868 3298, USA
J Thorac Oncol 6:2135-7. 2011..We have observed several patients who developed profound but asymptomatic sinus bradycardia (HR ≤45) during the course of crizotinib treatment...
- Reflex bradycardia during surgeryD J Doyle
Department of Anaesthesia, Toronto General Hospital, Ontario
Can J Anaesth 37:219-22. 1990Reflex bradycardia and sinus arrest may occur in a variety of surgical procedures, from neurosurgery to general abdominal, laparoscopic, ophthalmic and facial surgery and even procedures such as liver biopsies and electroconvulsive ..
- Apnea, bradycardia and desaturation in preterm infants before and after feedingC Slocum
Carillion Roanoke Community Hospital, Roanoke, VA, USA
J Perinatol 29:209-12. 2009..We aimed to measure objectively the effects of feeding on GER, apnea, bradycardia and desaturations.
- Carotid angioplasty and stent-induced bradycardia and hypotension: Impact of prophylactic atropine administration and prior carotid endarterectomyNeal S Cayne
Department of Vascular Surgery, New York University Medical Center, NY 10016, USA
J Vasc Surg 41:956-61. 2005We compared the physiologic effect of selective atropine administration for bradycardia with routine prophylactic administration, before balloon inflation, during carotid angioplasty and stenting (CAS)...
- Drugs that induce repolarization abnormalities cause bradycardia in zebrafishDavid J Milan
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston 02129, USA
Circulation 107:1355-8. 2003..Current in vitro preclinical assays are limited by biological simplicity, and in vivo models suffer from expense and low throughput...
- Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndromeColleen E Clancy
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Clin Invest 110:1251-62. 2002..These results link mutation-induced changes in Na+ channel gating mode transitions to heart rate-dependent changes in cellular electrical activity underlying a key LQT-3 clinical phenotype...
- Prognosis of the bradycardia pacemaker recipient assessed at first implantation: a nationwide cohort studyErik O Udo
Department of Cardiology, UMC Utrecht, Utrecht, The Netherlands
Heart 99:1573-8. 2013Pacing technology and care have improved notably over the past decade, justifying an update on the long-term prognosis and pre-implantation determinants of prognosis of bradycardia pacemaker (PM) recipients.
- NO-cGMP pathway at ventrolateral medullary cardiac inhibitory sites enhances the baroreceptor reflex bradycardia in the ratJanine Fletcher
Department of Physiology, The Medical School, The University of Birmingham, Birmingham B15 2TT, UK
Brain Res 1123:125-34. 2006..caudal brainstem within and around the nucleus ambiguus was systematically explored for sites producing a bradycardia of >50 bpm, without a change in blood pressure, using D,L homocysteic acid (DLH, 0...
- Economic and health consequences of managing bradycardia with dual-chamber compared to single-chamber ventricular pacemakers in ItalyHuseyin Baris Deniz
Caro Research Institute, Concord, Massachusetts 01742, USA
J Cardiovasc Med (Hagerstown) 9:43-50. 2008This study sought to estimate the economic implications of managing bradycardia due to sinoatrial node disease or atrioventricular block with dual compared to single-chamber ventricular pacemakers from an Italian government perspective...
- Biventricular pacing is superior to right ventricular pacing in bradycardia patients with preserved systolic function: 2-year results of the PACE trialJoseph Yat Sun Chan
Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Institute of Vascular Medicine, Li Ka Shing Institute of Health and Sciences, The Chinese University of Hong Kong, Hong Kong
Eur Heart J 32:2533-40. 2011..In the current analysis, we report the results at extended 2-year follow-up for changes in LV function and remodelling...
- Periprocedural hemodynamic instability with carotid angioplasty and stentingMahmoud M Taha
Neurosurgery Department, Mie University School of Medicine, Mie, Japan
Surg Neurol 70:279-85; discussion 285-6. 2008..Carotid angioplasty and stenting is used for treatment of carotid stenosis. Stent deployment may induce HDI and thereby cause systemic or neurologic deficits. This study defines characteristics and predictors of HDI with CAS...
- Apnea-induced changes in time estimation and its relation to bradycardiaThibaud Jamin
Laboratoire E S P EA 3162, Universite du Sud Toulon Var, La Garde, France
Aviat Space Environ Med 75:876-80. 2004..We tested time estimation (TE) during brief periods of voluntary apnea. We hypothesized that there would be a relationship between TE and heart rate (HR), a physiological indicator of arousal...
- Severe bradycardia and prolonged hypotension in ciguateraThomas Yan Keung Chan
Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Singapore Med J 54:e120-2. 2013..In addition to those symptoms, he developed dizziness, severe bradycardia (46 bpm) and prolonged hypotension, which required the administration of intravenous atropine and over three ..
- A possible role for atrial fibroblasts in postinfarction bradycardiaAndre Kamkin
Institute of Physiology, Humboldt University, Charite, Berlin, Germany
Am J Physiol Heart Circ Physiol 282:H842-9. 2002..These findings suggest that changes in the susceptibility of atrial fibroblasts to mechanical stretch may contribute to bradyarrhythmia during postinfarct remodeling of the heart...
- Diabetes-induced bradycardia is an intrinsic metabolic defect reversed by carnitineMichael A Malone
Julia Parrish Diabetes Research Institute, University of South Florida College of Medicine, Tampa, FL 33612 4742, USA
Metabolism 56:1118-23. 2007Rats with streptozotocin-induced diabetes (STZ-D) have reduced serum carnitine levels and bradycardia. Heart rates (HRs) of 24nondiabetic rats (NRs) and 24 STZ-D rats were compared...
- Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension, and diuresis are absent in N/OFQ peptide (NOP) receptor knockout miceMelissa A Burmeister
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Pharmacol Exp Ther 326:897-904. 2008Intracerebroventricular administration of the opioid-like peptide nociceptin/orphanin FQ (N/OFQ) produces bradycardia, hypotension, and diuresis in mice...
- Temporal variability of atrial fibrillation in pacemaker recipients for bradycardia: implications for crossover designed trials, study sample size, and identification of responder patients by means of arrhythmia burdenGiovanni Luca Botto
Cardiology Department, S Anna Hospital, Como, Italy
J Cardiovasc Electrophysiol 18:250-7. 2007....
- Marked sinus bradycardia and QT prolongation in a diabetic patient with severe hypoglycemiaRoberto Bolognesi
Chair of Cardiology, Dipartment of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy
J Diabetes Complications 25:349-51. 2011..an uncommon case of an insulin-treated diabetic patient, presenting severe hypoglycemia, coma, marked sinus bradycardia and QT prolongation...
- Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillationNana Duhme
Institute for Physiology and Pathophysiology, University of Heidelberg, INF 326, Heidelberg D 69120, Germany
Eur Heart J 34:2768-75. 2013..generation, regulation, and stabilization of heart rhythm and channel dysfunction is associated with inherited sinus bradycardia. We asked whether dysfunctional HCN4 channels also contribute to the generation of cardiac tachyarrhythmias.
- The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitabilityNeil Herring
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Parks Road, OX1 3PT, UK
J Mol Cell Cardiol 52:667-76. 2012..We hypothesize that impaired bradycardia to peripheral vagal stimulation following high-level sympathetic drive is due to sympatho-vagal crosstalk by ..
- Symptomatic bradycardia with oral aripiprazole and oral ziprasidoneBrian S Snarr
Department of Medicine, Medical University of South Carolina, Charleston, USA
Ann Pharmacother 44:760-3. 2010To describe the case of a patient who developed symptomatic bradycardia upon initiation of oral ziprasidone and later with oral aripiprazole, both of which resolved shortly after discontinuation of therapy.
- Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodiesPriya Chockalingam
Department of Pediatric Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
J Rheumatol 38:2682-5. 2011To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction.
- Functional basis of sinus bradycardia in congenital heart blockKeli Hu
Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System, SUNY Downstate Medical Center and NYU School of Medicine, Brooklyn, NY 11209, USA
Circ Res 94:e32-8. 2004..We recently established animal models of CHB and reported, for the first time, significant sinus bradycardia preceding AV block...
- Ruptured heterotopic pregnancy presenting with relative bradycardia in a woman not receiving reproductive assistanceMichael P Somers
Department of Emergency Medicine, University of Virginia Health System, Charlottesville, VA 22908 0699, USA
Ann Emerg Med 43:382-5. 2004..The patient failed to mount a tachycardic response to hemorrhagic shock. Bradycardia is a well-established phenomenon in the setting of hemoperitoneum and particularly with ruptured ectopic ..
- Orbital trauma, bradycardia, and vomiting: trapdoor fracture and the oculocardiac reflex: a case reportBenjamin F Jackson
Division of Emergency Medicine, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
Pediatr Emerg Care 26:143-5. 2010The presentation of vomiting and bradycardia after closed head trauma should invariably prompt concern for significant intracranial injury, yet other less common causes for the clinical picture do exist...
- Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathwayN Herring
University Laboratory of Physiology, Oxford, United Kingdom
Am J Physiol Heart Circ Physiol 281:H2318-27. 2001..cGMP production act in a similar way to nitric oxide (NO) by enhancing acetylcholine release and vagal-induced bradycardia. The effects of enzyme inhibitors and channel blockers on the action of atrial natriuretic peptide (ANP), brain-..
- Fetal bradycardia and disseminated coagulopathy: atypical presentation of amniotic fluid emboliR Levy
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel
Acta Anaesthesiol Scand 48:1214-5. 2004We present a parturient who developed an atypical case of amniotic fluid emboli presented by sudden fetal bradycardia, followed by maternal disseminated coagulopathy...
- Bradycardia during dexmedetomidine and therapeutic hypothermiaJoseph D Tobias
Department of Anesthesiology, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
J Intensive Care Med 23:403-8. 2008..Although generally safe and effective, occasional hemodynamic effects including bradycardia and hypotension have been reported...
- Cardiac effects of amodiaquine and sulfadoxine-pyrimethamine in malaria-infected African patientsB Ngouesse
, , , Cameroon
Am J Trop Med Hyg 65:711-6. 2001..Clinical and parasitological responses were monitored until Day 14. Bradycardia was observed in 16 of 20 amodiaquine-treated patients on Day 2, which corresponds to the time when maximal ..
- Hyperkalaemia causing profound bradycardiaK Noble
Heart 92:1063. 2006
- Factors influencing intraoperative bradycardia in adult patientsTomoko Yorozu
Department of Anesthesiology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
J Anesth 21:136-41. 2007In order to elucidate the prominent factors involved in intraoperative bradycardia in adult patients, we retrospectively investigated the association between the potential risk factors and intraoperative bradycardia, using multiple ..
- Frequency of hypotension and bradycardia during general anesthesia, epidural anesthesia, or integrated epidural-general anesthesia for total hip replacementBattista Borghi
IRCSS Istituti Ortopedici, Rizzoli, Bologna, Italy
J Clin Anesth 14:102-6. 2002To evaluate the frequency of hypotension and bradycardia during integrated epidural-general anesthesia as compared with general anesthesia or epidural anesthesia alone.
- Sinus bradycardia after intravenous pulse methylprednisoloneJonathan D Akikusa
Division of Rheumatology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
Pediatrics 119:e778-82. 2007..Here we report our experience over a 6-month period with 5 children with rheumatic diseases who developed sinus bradycardia during consecutive daily therapy with intravenous pulse methylprednisolone...
- Acromegaly presenting with diabetic ketoacidosis, associated with retinitis pigmentosa and octreotide-induced bradycardia: a case report and a review of the literatureCihangir Erem
Department of Internal Medicine, Division of Endocrinology and Metabolism, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
Endocrine 30:145-9. 2006..During the medical treatment with octreotide, symptomatic sinusoidal bradycardia was developed (pulse rate 45 bpm, and blood pressure 70/40 mmHg). Octreotide therapy was stopped...
- The effect of atrial pacing therapies on atrial tachyarrhythmia burden and frequency: results of a randomized trial in patients with bradycardia and atrial tachyarrhythmiasMichael A Lee
John Muir Mount Diablo Medical Center, Walnut Creek, California, USA
J Am Coll Cardiol 41:1926-32. 2003..The Atrial Therapy Efficacy and Safety Trial (ATTEST) was a prospective, randomized study to evaluate preventive pacing and antitachycardia pacing (ATP) in patients with symptomatic atrial fibrillation (AF) or atrial tachycardia (AT)...
- Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutationsJean Marc Lupoglazoff
Pediatric Cardiology, Necker Enfants Malades AP HP, Paris, France
J Am Coll Cardiol 43:826-30. 2004..We hypothesized that neonatal long QT syndrome (LQTS) with 2:1 atrioventricular block (AVB) could be related to HERG mutations...
- Severe maternal bradycardia and asystole after combined spinal-epidural labor analgesia in a morbidly obese parturientPeter H Pan
Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
J Clin Anesth 16:461-4. 2004Serious maternal bradycardia and asystole in laboring parturients after combined spinal-epidural labor analgesia are rare...
- Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious ratsGregg R Ward
Department of Pharmacology, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
BMC Pharmacol 6:2. 2006Previous studies have shown that testosterone enhances baroreflex bradycardia. Therefore, conscious unrestrained rats were used to investigate the role of the androgen receptor in the testosterone-mediated modulation of baroreflex ..
- [Relationship between efficacy of electroacupuncture and electroacupuncture stimulation of different acupoints and different tissue layers of acupoint area in hypotension plus bradycardia rats]Bin Xu
Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of the People s Republic of China, Nanjing University of Chinese Medicine, Nanjing 210029, China
Zhen Ci Yan Jiu 35:422-8. 2010..between the effect of electroacupuncture (EA) and EA of different layer tissues of the acupoint area and different acupoints in upregulating mean arterial pressure (MAP) and heart rate (HR) in hypotension plus bradycardia rats.
- Heart rate regulation and extreme bradycardia in diving emperor penguinsJessica U Meir
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
J Exp Biol 211:1169-79. 2008..In contrast to any other freely diving bird, a true bradycardia (f(H) significantly <f(H) at rest) occurred during diving [dive f(H) (total beats/duration)=57+/-2 beats min(..
- Repetitive paired stimulation of nasotrigeminal and peripheral chemoreceptor afferents cause progressive potentiation of the diving bradycardiaMiroslav Rozloznik
Dept of Neuro and Sensory Physiology, Georg August Univ Humboldtallee 23, 37073 Gottingen, Germany
Am J Physiol Regul Integr Comp Physiol 296:R80-7. 2009Hallmarks of the mammalian diving response are protective apnea and bradycardia. These cardiorespiratory adaptations can be mimicked by stimulation of the trigeminal ethmoidal nerve (EN5) and reflect oxygen-conserving mechanisms during ..
- Bradycardia due to hydrogen peroxide irrigation during craniotomy for craniopharyngiomaHemanshu Prabhakar
Department of Neuroanesthesiology, All India Institute of Medical Sciences, New Delhi 110029, India
J Clin Neurosci 14:488-90. 2007..A sudden bradycardia occurred after instillation of hydrogen peroxide solution at the surgical site...
- Changes in left ventricular repolarization and ion channel currents following a transient rate increase superimposed on bradycardia in anesthetized dogsM Rubart
Department of Medicine, Indiana University School of Medicine, Krannert Institute of Cardiology, Indianapolis 46202 4800, USA
J Cardiovasc Electrophysiol 11:652-64. 2000We previously demonstrated in dogs that a transient rate increase superimposed on bradycardia causes prolongation of ventricular refractoriness that persists for hours after resumption of bradycardia...
- Does heart rate variability predict hypotension and bradycardia after induction of general anaesthesia in high risk cardiovascular patients?R Hanss
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
Anaesthesia 63:129-35. 2008..measurement of heart rate variability and were then assigned according to haemodynamic events (hypotension or bradycardia) after standardised induction of anaesthesia into 'stable' (n = 39) and 'unstable' patients (n = 11)...
- Severe bradycardia after anesthesia before electroconvulsive therapyTom K Birkenhager
Departments of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
J ECT 26:53-4. 2010Postanesthesia bradycardia or asystole before electroconvulsive therapy (ECT) occurs very infrequently but is a potentially fatal complication of pre-ECT anesthesia...
- Asystole and bradycardia related to anesthetic induction during ECT: a case reportMark J Russ
J ECT 20:195-7. 2004
- GABAergic neurotransmission at the nucleus tractus solitarii in the suppression of reflex bradycardia by parabrachial nucleusW B Len
Team of Biomedical Science, Chang-Gung Institute of Nursing, Taoyuan, Taiwan
Synapse 42:27-39. 2001..These results suggest that a direct GABAergic descending projection from the KF subnucleus and surrounding areas of the PBN complex to the NTS may inhibit cardiac BRR response by activating GABA(A) and GABA(B) receptors at the NTS...
- Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil?Koichi Maruyama
Department of Anesthesiology, Saitama Medical University International Medical Center, 1397 1 Yamane, Hidaka, Saitama, 350 1298, Japan
J Anesth 24:293-6. 2010This study was conducted to examine whether pretreatment with intravenous atropine could prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil in a prospective randomized ..
- Assessment of atrial regional wall motion using strain Doppler imaging during biatrial pacing in the bradycardia-tachycardia syndromeKatsumi Matsumoto
Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
Pacing Clin Electrophysiol 29:220-5. 2006..Biatrial pacing is expected to have preventive effects on atrial fibrillation...
- Predictors of bradycardia during the stimulation phase of electroconvulsive therapyJosef Nagler
Christophsbad Clinic, Goppingen, Germany
J ECT 27:201-6. 2011..Temporary asystole can be detected at various time points during electroconvulsive treatment. We carefully monitored and documented its incidence during stimulation to evaluate currently known and assumed predictors...
- Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotensionN R Keller
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, AA3228 MCN, Nashville, TN 37232 2195, USA
Neuroscience 139:931-46. 2006..Upon placement in the behavioral chamber, norepinephrine transporter-deficient mice demonstrated a notable bradycardia and depressor effect that was more pronounced in females...
- Crisis management during anaesthesia: bradycardiaL M Watterson
Sydney Medical Simulation Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia
Qual Saf Health Care 14:e9. 2005b>Bradycardia in association with anaesthesia may have many potential causes and associated conditions, some rare and/or obscure. A prompt appropriate response is important as some homeostatic mechanisms may be impaired under anaesthesia.
- The relationship between sinus node dysfunction, bradycardia-mediated atrial remodelling, and post-operative atrial flutter in patients with congenital heart defectsNatasja M S de Groot
Eur Heart J 27:2036-7. 2006
- Bradycardia and hypotension refractory to ephedrine and atropine treatment: severe autonomic dysfunction with abnormal heart rate variabilityHuei Chi Horng
Taichung Armed Forces General Hospital, Taiwan, ROC
Acta Anaesthesiol Taiwan 44:109-12. 2006..here report a 48-year-old male patient with diabetes mellitus who suffered from intraoperative hypotension and bradycardia which did not respond to ephedrine and atropine treatment and eventuated in cardiac arrest...
- Beneficial effects of biatrial pacing on cardiac function in patients with bradycardia -- tachycardia syndromeKatsumi Matsumoto
Second Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
Circ J 69:831-6. 2005..Biatrial (BiA) pacing prevents atrial fibrillation. By an unknown mechanism. The purpose of this study was to use Doppler echocardiography to evaluate the hemodynamic effects during BiA pacing...
- Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control groupNathalie Costedoat-Chalumeau
Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Arthritis Rheum 50:3187-94. 2004Aside from congenital heart block (CHB), sinus bradycardia and prolongation of the corrected QT (QTc) interval have been reported in infants born to mothers with anti-SSA antibodies...
- Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitroN Herring
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
J Physiol 535:507-18. 20011. We tested the hypothesis that nitric oxide (NO) augments vagal neurotransmission and bradycardia via phosphorylation of presynaptic calcium channels to increase vesicular release of acetylcholine. 2...
- Bradycardia and hypotension associated with fomepizole infusion during hemodialysisKatherine J Lepik
BC Drug and Poison Information Centre, Vancouver, British Columbia, Canada
Clin Toxicol (Phila) 46:570-3. 2008We report a case of hypotension and bradycardia associated with intravenous fomepizole infusion.
- Biventricular pacing in patients with bradycardia and normal ejection fractionCheuk Man Yu
Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
N Engl J Med 361:2123-34. 2009..we examined whether biventricular pacing is superior to right ventricular apical pacing in preventing deterioration of left ventricular systolic function and cardiac remodeling in patients with bradycardia and a normal ejection fraction.
- Dexmedetomidine-associated bradycardia progressing to pulseless electrical activity: case report and review of the literatureAnthony T Gerlach
Department of Pharmacy, The Ohio State University Medical Center, Ohio 43210, USA
Pharmacotherapy 29:1492. 2009..It is a distinctive sedative because it does not cause respiratory depression, but it may cause hypotension and bradycardia. We describe a 74-year-old man who was receiving dexmedetomidine for agitation and experienced progressive ..
- How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures?Brian D Moseley
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Epilepsia 51:1219-24. 2010..The purpose of this study was to determine the prevalence and risk factors for ictal hypoxemia (oxygen saturation <90%) and ictal bradycardia (heart rate < second percentile for age) in children during recorded seizures.
- Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require ANP receptorLisa M Hunt
Dept of Biology, Williams College, Williamstown, MA 01267, USA
Am J Physiol Heart Circ Physiol 287:H1446-51. 2004..Furthermore, circulating ANP levels and data from NPR1(-/-) and NPR3(-/-) mice suggest that the ANP pathway may not be involved in the cardiovascular response to CR...
- [Therapeutic drug monitoring in perioperative period--management of atrial fibrillation in a patient with bradycardia due to relative overdose of digitalis]T Murakawa
Department of Anesthesiology, Odate Municipal Hospital
Masui 46:521-4. 1997We reported a 79 year old man with preoperative bradycardia due to relative overdose of digitalis prior to undergoing subtotal gastrectomy. The patient had received metildigoxin 0.2 mg...
- The effect of electrode placement and pulsewidth on asystole and bradycardia during the electroconvulsive therapy stimulusPatrick T Stewart
School of Psychiatry, University of New South Wales, Sydney, Australia
Int J Neuropsychopharmacol 14:585-94. 2011..The degree of bradycardia (any slowing of heart rate) and incidence of asystole (absence of heart beats for ≥5 s) during the ECT ..
- Sudden bradycardiaGeorge Nikolic
Intensive Care Unit, The Canberra Hospital, Canberra, Australia
Heart Lung 40:177-9. 2011
- Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillationRobert A Rose
Department of Physiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Circ Arrhythm Electrophysiol 4:733-42. 2011..A major prognostic indicator of survival in patients with CIO is iron-mediated cardiomyopathy characterized by contractile dysfunction and electrical disturbances, including slow heart rate (bradycardia) and heart block.
- Bradycardia and vecuronium: comparison with alcuronium during cholecystectomyC P Morton
Department of Anaesthetics, Royal Infirmary of Edinburgh
Br J Anaesth 68:619-20. 1992We have compared the incidence of bradycardia in two groups of patients undergoing cholecystectomy...
- [Torsade de pointes associated with severe bradycardia after induction of general anesthesia]Eisuke Hamaguchi
Department of Anesthesiology, Tokushima University Hospital, Tokushima 770 8503
Masui 60:1097-100. 2011..Just after induction of anesthesia, sinus bradycardia occurred, and 9 minutes after tracheal intubation, ECG suddenly showed torsade de pointes (TdP) and the ..
- Reflex bradycardia in facial surgeryD G Stott
Department of Anaesthetics, Stepping Hill Hospital, Stockport
Br J Plast Surg 42:595-7. 1989..An awareness of its management can obviate morbidity and mortality. An account of the phenomenon, its treatment and illustrative case histories are presented...
- Factors that Initiate Arrhythamias in Long QT SyndromeGuy Salama; Fiscal Year: 2006..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs and TdP...
- Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot StudyJill M Wecht; Fiscal Year: 2010..persons, individuals with tetraplegia represent a model of sympathetic denervation characterized by relative bradycardia and low resting blood pressure...
- Thyroid Hormone ActionTHOMAS STERLING SCANLAN; Fiscal Year: 2013..Acute administration of T1AM rapidly induces hypothermia, bradycardia, and hyperglycemia in rodents...
- Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone MetabolTHOMAS STERLING SCANLAN; Fiscal Year: 2013..Single doses of T1AM rapidly induce hypothermia, bradycardia, and hyperglycemia in rodents...
- AREA: Rapamycin, ambient temperature, and longevitySteven J Swoap; Fiscal Year: 2010..also requires the same cold stress for maximum lifespan extension, 2) significant metabolic depression, bradycardia, and hypothermia are required for rapamycin's effect on lifespan extension, and 3) despite a normal body ..
- NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONSDavid Mendelowitz; Fiscal Year: 2013..Acute exposure to hypoxia evokes an initial tachycardia followed by a bradycardia. Previous work from this lab, and others, have shown brief (5-15 minute) periods of hypoxia and/or hypercapnia ..
- Nicotine Modulation of Parasympathetic Cardiac NeuronsDavid Mendelowitz; Fiscal Year: 2013..of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
- CaMKII in Sinus Node Physiology and DiseaseMark E Anderson; Fiscal Year: 2013..SND causes symptomatic bradycardia and sudden death, particularly in patients and animal models with hypertension or heart failure, conditions ..
- PARASYMPATHETIC DYSFUNCTION IN OBESITY: EFFECT OF CHOLESTEROL ON VAChTYifan Li; Fiscal Year: 2013..Vagal stimulation (VS)-induced bradycardia and Ach release in atria, and VAChT protein levels and Ach uptake activity in synaptic vesicles from PSNS ..
- Mechanisms of cardiac Ca dysregulation and arrhythmias in ankyrin B deficiencySanda Despa; Fiscal Year: 2013..LQT4, humans with AnkB loss-of-function mutations display a complex cardiac phenotype that also includes bradycardia, stress-induced ventricular arrhythmias and sudden cardiac death...
- MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATESDavid Mendelowitz; Fiscal Year: 2013The diving reflex is the most powerful autonomic reflex. Stimulation of the diving reflex evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
- Thyroid Hormone ActionThomas Scanlan; Fiscal Year: 2009..T1AM rapidly induces hypothermia, bradycardia, and hyperglycemia in rodents...
- Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neuronsEugen Brailoiu; Fiscal Year: 2012..that microinjection of G-1, a specific GPR30 agonist, or 17-estradiol (E2) into the nucleus ambiguus produces bradycardia;the effect was abolished by prior administration of G-36, a GPR30 antagonist...
- Actuated, Low-Stress, Endotracheal Tube Cleaner to Improve Neonate Lung FunctionROGER BROOKS BAGWELL; Fiscal Year: 2013..Risks associated with suctioning include hypoxia (low oxygen in blood), bradycardia (low heart rate), or atelectasis (collapse of part of the lung)...
- Prenatal ethanol exposure, arousal and the Sudden Infant Death Syndrome (SIDS)Robert A Darnall; Fiscal Year: 2013..die of SIDS, however, have arousal deficits that prevent an adequate response to multiple episodes of apnea, bradycardia and hypoxia...
- Abstinence and Drug Withdrawal: Innovative Translational Methods for NeonatesELISABETH BLOCH SALISBURY; Fiscal Year: 2013..g., bradycardia, tachycardia) and respiration, including decreasing incidents of apnea, periodic breathing and tachypnea;2) ..
- Wireless Novel MicroEEG for Neonatal Apnea and Community Neurological NetworkZACHARY H IBRAHIM; Fiscal Year: 2013DESCRIPTION (provided by applicant): Most preterm infants have episodes of apnea (cessation of breathing), bradycardia (low heart rate), and desaturations (low levels of oxygen in the blood) or what is collectively called as ABD events...
- TRPV1 Function at Laryngeal Labeled NTS NeuronsMackenzie E Hofmann; Fiscal Year: 2013..Activation of this reflex results in apnea and bradycardia and can be prolonged by temperature increases in the nucleus of the solitary tract (NTS) in the brainstem...
- Characterization of autonomic dysfunction in Rett syndrome &other MECP2 disorderJeffrey L Neul; Fiscal Year: 2013..Boys with mutations in MECP2 and congenital encephalopathy have a number of autonomic abnormalities including bradycardia, apnea, and respiratory arrest resulting in death in the first three years of life...
- MIR-1-2 FUNCTION IN CARDIAC CONDUCTION SYSTEM DEVELOPMENT AND MAINTENANCEYong Zhao; Fiscal Year: 2013..miR-1s repress cell proliferation. Overexpression of miR-1-2 causes bradycardia and arrhythmias...
- Identification of the anti-neoplastic target of bioactive FTY720 analogsStephen Hanessian; Fiscal Year: 2013..success in animal models, FTY720 cannot be tested in human cancer patients because it triggers profound bradycardia by activating S1P receptors 1 and 3 before the anti-neoplastic dose is reached...
- Autonomic consequences of brief seizuresMark Stewart; Fiscal Year: 2004..A broader spectrum of autonomic signs, including changes in heart rate and rhythm (most often bradycardia), blood pressure (most often pressure increases), pupillary size, vasomotor and sudomotor activity, GI motility ..
- Unbiased screens in zebrafish for new classes of cyanide countermeasureCalum A Macrae; Fiscal Year: 2011..We have developed a zebrafish model in which exposure to cyanide causes stereotypical toxicities including bradycardia, neuronal necrosis, and death...
- CELLULAR BIOLOGY OF CARDIAC SODIUM-CALCIUM EXCHANGEKENNETH PHILIPSON; Fiscal Year: 2013..recently produced novel atrial-specific NCX knockout (KO) mice that live into adulthood, but exhibit profound bradycardia and sinaotrial node (SAN) dysfunction...
- Sensory C Fibers in the Upper AirwaysTHOMAS EDWARD TAYLOR-CLARK; Fiscal Year: 2011..itch, congestion, mucus secretion, bronchospasm, altered respiratory pattern, arterial hypotension and bradycardia. The specific nature of a given reflex response is likely due to the type of upper airway afferent nerve that ..
- Activity dependent mechanisms of olfactory system developmentArie Sitthichai Mobley; Fiscal Year: 2013..The experiments proposed here may have broad implications for Ih channelopathies including sinus bradycardia, epilepsy, and peripheral neuropathic pain.
- Ultra Low Power Integrated Circuits and Systems for Cardiac PacemakersEugene B John; Fiscal Year: 2013..any part of the conduction system is dysfunctional for some reason, the normal heartbeat may become too slow (bradycardia) or fast (tachycardia100bpm). These are abnormal heart rhythms, or arrhythmias...
- OPIOMELANOCORTIN PEPTIDES AND CARDIOVASCULAR REGULATIONGeorge Kunos; Fiscal Year: 1999..in rats, we will define the alpha-2 AR sub-types in the arcuate nucleus which mediate hypotension and bradycardia. Inhibition of these effects in the NTS by anti-sera against the beta-endorphin and alpha-MSH or by antagonists ..
- UNDERSTANDING THE ROLES OF MIR-1S IN REGULATING HEART DEVELOPMENTYong Zhao; Fiscal Year: 2013..Overexpression of miR-1-2 at postnatal stages causes AV block of various degree and sinus bradycardia. The PI hypothesizes that the proper function of each component of the CCS requires a precise dosage of miR-1...
- CNS MEDIATION OF CONDITIONED BRADYCARDIAPHILIP MC CABE; Fiscal Year: 1990..In the rabbit, the conditioned heart rate response consists of heart rate slowing (bradycardia)...
- PACEmaker &Beta-Blocker Therapy Post-Myocardial InfarctJeffrey J Goldberger; Fiscal Year: 2013..of total mortality plus nonfatal reinfarction in patients who have suffered a myocardial infarction and have bradycardia contraindications to beta blockers...
- Planning Grant for PRESOX TrialNeil Finer; Fiscal Year: 2009..either 30% or 60% oxygen, and the oxygen concentration will be increased in the Low group for either continued bradycardia, or SpO2 values of less than 70% at 4 minutes, or less than 80% at 7 minutes, and Na SpO2 of 85% at 10 minutes...
- AUTONOMIC FUNCTION IN RENOVASCULAR HYPERTENSIONBARBARA BARRON; Fiscal Year: 2000..For instance, enkephalins reduce vagally-mediated bradycardia. Conversely, adrenergic stimulation to cardiomyocytes causes increased enkephalin production...
- Effects of Noise on Newborns < 1000g BirthweightRobert Lasky; Fiscal Year: 2007..2. To identify sound characteristics in NICUs that disrupt sleep or increase episodes of apnea, bradycardia, or desaturation in ELBW infants...
- TRH in mediating the bradycardia of caloric restrictionSteven Swoap; Fiscal Year: 2005..The overall goal of this proposal is to elucidate the underlying mechanism(s) of the bradycardia induced by the reduction of caloric intake...
- Trigeminal Autonomic InteractionsPaul McCulloch; Fiscal Year: 2002..This reflex includes central apnea, parasympathetic bradycardia and sympathetically mediated vasoconstriction...
- PRECISE CONTOL OF TONGUE MOVEMENTStephen Goldberg; Fiscal Year: 2005..Attempts to begin bottle feeding these infants can result in apnea, bradycardia, hypoxia, fatigue and agitation and there can also be the long term consequence of delayed oral feeding ..
- Neuroplasticity and the carotid bodyEstelle Gauda; Fiscal Year: 2009..Furthermore, these infants are at high risk for persistent apnea and bradycardia, reduced arousal responses during sleep, and sudden death which are all adverse physiological events related to ..
- Role of Ca channels in congenital heart blockMohamed Boutjdir; Fiscal Year: 2007..We have also reported for the first time significant sinus bradycardia unrelated to AV block...
- ELECTROPHYSIOLOGY OF RIGHT ATRIAL PACEMAKERSSTEPHEN LIPSIUS; Fiscal Year: 2000..e. postvagal tachycardia, 2) digitalis elicits a bradycardia by somehow sensitizing the atria to cholinergic inhibition, 3) nitric oxide may play an obligatory role in the ..
- Air Pollution and Cardiorespiratory Events In InfantsPaige Tolbert; Fiscal Year: 2003..the first of its kind, is to examine the occurrence of cardiorespiratory events (in particular, apnea and bradycardia) in infants on home cardiorespiratory monitors in relation to daily measures of ambient air pollution in the ..
- OXYGEN SATURATION MONITORING IN NEONATESSHYANG YUN SHIAO; Fiscal Year: 2001..Neonates on ventilators are more sensitive to stimuli and frequently develop desaturation episodes, apnea, and bradycardia. They are at greater risk of hypoxemia, in part because of their high fetal hemoglobin level...
- ENDOTRACHEAL SUCTIONING IN NEWBORNSBarbara Turner; Fiscal Year: 1993..ventilator) and level of hyperoxygenation (10% vs 20% increase in FIO2) to prevent suction induced hypoxemia, bradycardia, hyper/hypocarbia and increased ICP...
- HYPOTHYROID AND AUTONOMIC CHANGES--ROLE OF MEDULLARY TRHHong Yang; Fiscal Year: 1999The central mechanisms responsible for the bradycardia, high blood pressure, gastrointestinal motility disorder, and gastric atrophy induced by hypothyroidism remains unknown...
- The Role of Epinephrine in Neurally Mediated SyncopeSatish Raj; Fiscal Year: 2009..followed by a sudden withdrawal of sympathetic tone and increase in vagal tone, with resultant vasodilation and bradycardia. Recent studies have found that the level of epinephrine rises PRIOR to syncope...
- Role of Cardiac Fibrosis in ArrhythmogenesisAmy de Jongh Curry; Fiscal Year: 2006..In addition, 30-50% of these deaths are sudden and have been attributed to ventricular tachyarrhythmias, bradycardia, and electro-mechanical dissociation...
- Coupling mechanisms of OP4 receptor and calcium channelsVictor Ruiz Velasco; Fiscal Year: 2006..Noc-mediated OP4 receptor activation elicits cardiovascular responses such as bradycardia and hypotension via pathways that influence the autonomic nervous system--mostly through an inhibition of ..
- NURSING INTERVENTIONS USED IN FEEDING PRETERM INFANTSALICE HILL; Fiscal Year: 2002..g., apnea, bradycardia, oxygen desaturation, untoward changes in behavioral state changes, and changes in sucking pattern ..
- Predicting life-threatening events in CHIME infant dataStephanie Schuckers; Fiscal Year: 2003..is a relationship between SIDS and infants who have apparent life-threatening events (ALTE) like apnea and bradycardia, there is a desire to gain a better understanding of the nature of ALTE, their frequency and severity, and the ..
- HOME APNEA MONITORING IN INFANTS AT RISK FOR SIDSToke Hoppenbrouwers; Fiscal Year: 1991..These infants will participate in a program involving home monitoring of apnea, bradycardia and oxygen with computer storage of these events...
- 5-HT1A-agonist mediated recovery in hypovolemic shockKarie Scrogin; Fiscal Year: 2007..These compensatory responses suddenly abate after significant blood loss (20-30%), resulting in hypotension, bradycardia and sympathoinhibition...
- NON-CONTACT MONITOR FOR INFANTS AT RISK FOR SIDSDAVID GERDT; Fiscal Year: 1999..The strategy is to detect such episodes of bradycardia and apnea at their inception, and then to physically the arouse the child...
- Wireless Cardiorespiratory Monitor for NeonatesMICHAEL SCIARRA; Fiscal Year: 2004..adapt the respiratory sensor to distinguish between central, obstructed, or mixed apnea; 2) implement apnea and bradycardia event detection; 3) explore implementation of an oximetric sensor; and 4) expand the validation study beyond ..
- ELECTROPHYSIOLOGY OF CARDIAC AUTOMATICITYJoseph Spear; Fiscal Year: 1980..experiments will provide information relevant to mechanisms of various cardiac arrhythmias including sinus node bradycardia, sinus arrest, bradycardia-tachycardia syndrome, sinus node exit block, sinus node reenINVALID ACTION CODE ..
- Newborn brain oxygenation and cellular injuryAnna Pastuszko; Fiscal Year: 2005..Apneic episodes longer than 15 s and accompanied by hypoxia or bradycardia have been reported to occur in all infants with gestational ages less than 34 weeks...
- Functional basis of bradycardia in congenital heart blocYongxia Qu; Fiscal Year: 2005The long-term goal is to elucidate the mechanisms underlying autoimmune-associated sinus bradycardia. Significant sinus bradycardia was observed in infants from mothers with anti-Ro/La autoantibodies, and in pups from Ro/La immunized ..
- CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGEPATRICE GUYENET; Fiscal Year: 2003..This second or ~ decompensatory~ phase of hemorrhage is characterized by bradycardia and a sharp decrease of sympathetic activity ( hemorrhage-induced sympathoinhibiton...
- A Molecular Study of Cardiac Repolarization David Milan; Fiscal Year: 2009..Our preliminary data suggest that disturbances of repolarization are manifest as bradycardia in the zebrafish, and that this organism will provide a good model for the analysis of cardiac repolarization...
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMMartin Farias; Fiscal Year: 2002..that: MEAP acting on delta II opioid receptors located prejunctionally in the sinoatrial node suppresses vagal bradycardia by interrupting the NOcGMP pathway. 1...
- A 4-Pole Micro-Leadwire for Multi-Chamber Cardiac PacingGeoffrey Kotzar; Fiscal Year: 2001..5 billion last year. This market includes bradycardia implants, implantable cardioverter defibrillators (ICD), and external automated defibrillators...
- Zebrafish Screen for Drug-Induced Long QT & Cyp3ATIMOTHY BARANOWSKI; Fiscal Year: 2005..A recent study showed that compounds that cause long QT in humans cause bradycardia in live zebrafish embryos...
- A MICRO-STIMULATION LEADWIRE FOR CARDIAC PACINGBRYAN BOHANAN; Fiscal Year: 2000..5 billion last year. This market includes bradycardia implants, implantable cardioverter defibrillators (ICD), and external automated defibrillators...
- Genetic Studies of Cardiac Pacemaking in the ZebrafishCalum MacRae; Fiscal Year: 2004..The zebrafish mutant slo mo (smo) displays heritable intrinsic bradycardia but exhibits no other developmental defect...
- GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSIONMorton Printz; Fiscal Year: 2007..genes in new QTL discovered for mild airpuff startle stress-elicited tachycardia and pressor responses, for bradycardia associated with the Orienting Response, and for a cluster of blood pressure QTL on chromosome 2. Dr...
- THE CPA: SOMATIC AND AUTONOMIC SYSTEMSW Panneton; Fiscal Year: 2004..Understanding the brainstem mechanisms governing he vascular constriction after either of these somatic stimuli may provide a neurological explanation for this. Such knowledge may lead to an understanding of essential hypertension. ..
- Behavioral state development in infantsMark Blumberg; Fiscal Year: 2009..abstract_text> ..