chronic pancreatitis

Summary

Summary: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.

Top Publications

  1. Chang M, Chang Y, Wei S, Liang P, Jan I, Su Y, et al. Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan. Pancreatology. 2009;9:287-92 pubmed publisher
    Variations and haplotypes of the chymotrypsin C (CTRC) gene in Chinese patients with chronic pancreatitis (CP) and control subjects with genotype-phenotype correlation were investigated...
  2. Kobayashi T, Manivel J, Bellin M, Carlson A, Moran A, Freeman M, et al. Correlation of pancreatic histopathologic findings and islet yield in children with chronic pancreatitis undergoing total pancreatectomy and islet autotransplantation. Pancreas. 2010;39:57-63 pubmed publisher
    The probability of insulin independence after intraportal islet autotransplantation (IAT) for chronic pancreatitis (CP) treated by total pancreatectomy (TP) relates to the number of islets isolated from the excised pancreas...
  3. Nøjgaard C, Bendtsen F, Becker U, Andersen J, Holst C, Matzen P. Danish patients with chronic pancreatitis have a four-fold higher mortality rate than the Danish population. Clin Gastroenterol Hepatol. 2010;8:384-90 pubmed publisher
    We investigated mortality of patients with chronic pancreatitis (CP), compared with the Danish population and sought to determine whether clinical presentations of CP can be used in prognosis...
  4. Law R, Parsi M, Lopez R, Zuccaro G, Stevens T. Cigarette smoking is independently associated with chronic pancreatitis. Pancreatology. 2010;10:54-9 pubmed publisher
    It is not completely understood whether smoking contributes to chronic pancreatitis (CP). Past studies have included mostly patients with alcohol-related and severe CP...
  5. Derikx M, Drenth J. Genetic factors in chronic pancreatitis; implications for diagnosis, management and prognosis. Best Pract Res Clin Gastroenterol. 2010;24:251-70 pubmed publisher
    b>Chronic pancreatitis (CP) is a clinical situation with persisting inflammation leading to destruction of the pancreas ensuing endocrine and exocrine failure...
  6. Ulmasov B, Xu Z, Talkad V, Oshima K, Neuschwander Tetri B. Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse. Am J Physiol Gastrointest Liver Physiol. 2010;299:G70-80 pubmed publisher
    ..The role of RAS in the development of chronic pancreatitis is not well established...
  7. Bhanot U, Moller P. Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesis. Lab Invest. 2009;89:489-97 pubmed publisher
    The pathobiology of chronic pancreatitis (CP) remains enigmatic despite remarkable progress made recently in uncovering key mechanisms involved in the initiation and progression of the disease...
  8. Zhang W, Gao J, Zhao T, Wu W, Bai Y, Zou D, et al. High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis. Pancreas. 2010;39:293-300 pubmed publisher
    Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for the treatment of pain in chronic pancreatitis (CP)...
  9. Bedi M, Gandhi M, Jacob G, Lekha V, Venugopal A, Ramesh H. CA 19-9 to differentiate benign and malignant masses in chronic pancreatitis: is there any benefit?. Indian J Gastroenterol. 2009;28:24-7 pubmed publisher
    The role of the tumor marker CA 19-9 in differentiating benign from malignant masses in chronic pancreatitis has not been extensively studied...
  10. Nguyen Tang T, Dumonceau J. Endoscopic treatment in chronic pancreatitis, timing, duration and type of intervention. Best Pract Res Clin Gastroenterol. 2010;24:281-98 pubmed publisher
    Endoscopic treatment of chronic pancreatitis (CP) aims to relieve pain by draining the main pancreatic duct (MPD) and to treat loco-regional complications...

Detail Information

Publications62

  1. Chang M, Chang Y, Wei S, Liang P, Jan I, Su Y, et al. Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan. Pancreatology. 2009;9:287-92 pubmed publisher
    Variations and haplotypes of the chymotrypsin C (CTRC) gene in Chinese patients with chronic pancreatitis (CP) and control subjects with genotype-phenotype correlation were investigated...
  2. Kobayashi T, Manivel J, Bellin M, Carlson A, Moran A, Freeman M, et al. Correlation of pancreatic histopathologic findings and islet yield in children with chronic pancreatitis undergoing total pancreatectomy and islet autotransplantation. Pancreas. 2010;39:57-63 pubmed publisher
    The probability of insulin independence after intraportal islet autotransplantation (IAT) for chronic pancreatitis (CP) treated by total pancreatectomy (TP) relates to the number of islets isolated from the excised pancreas...
  3. Nøjgaard C, Bendtsen F, Becker U, Andersen J, Holst C, Matzen P. Danish patients with chronic pancreatitis have a four-fold higher mortality rate than the Danish population. Clin Gastroenterol Hepatol. 2010;8:384-90 pubmed publisher
    We investigated mortality of patients with chronic pancreatitis (CP), compared with the Danish population and sought to determine whether clinical presentations of CP can be used in prognosis...
  4. Law R, Parsi M, Lopez R, Zuccaro G, Stevens T. Cigarette smoking is independently associated with chronic pancreatitis. Pancreatology. 2010;10:54-9 pubmed publisher
    It is not completely understood whether smoking contributes to chronic pancreatitis (CP). Past studies have included mostly patients with alcohol-related and severe CP...
  5. Derikx M, Drenth J. Genetic factors in chronic pancreatitis; implications for diagnosis, management and prognosis. Best Pract Res Clin Gastroenterol. 2010;24:251-70 pubmed publisher
    b>Chronic pancreatitis (CP) is a clinical situation with persisting inflammation leading to destruction of the pancreas ensuing endocrine and exocrine failure...
  6. Ulmasov B, Xu Z, Talkad V, Oshima K, Neuschwander Tetri B. Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse. Am J Physiol Gastrointest Liver Physiol. 2010;299:G70-80 pubmed publisher
    ..The role of RAS in the development of chronic pancreatitis is not well established...
  7. Bhanot U, Moller P. Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesis. Lab Invest. 2009;89:489-97 pubmed publisher
    The pathobiology of chronic pancreatitis (CP) remains enigmatic despite remarkable progress made recently in uncovering key mechanisms involved in the initiation and progression of the disease...
  8. Zhang W, Gao J, Zhao T, Wu W, Bai Y, Zou D, et al. High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis. Pancreas. 2010;39:293-300 pubmed publisher
    Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for the treatment of pain in chronic pancreatitis (CP)...
  9. Bedi M, Gandhi M, Jacob G, Lekha V, Venugopal A, Ramesh H. CA 19-9 to differentiate benign and malignant masses in chronic pancreatitis: is there any benefit?. Indian J Gastroenterol. 2009;28:24-7 pubmed publisher
    The role of the tumor marker CA 19-9 in differentiating benign from malignant masses in chronic pancreatitis has not been extensively studied...
  10. Nguyen Tang T, Dumonceau J. Endoscopic treatment in chronic pancreatitis, timing, duration and type of intervention. Best Pract Res Clin Gastroenterol. 2010;24:281-98 pubmed publisher
    Endoscopic treatment of chronic pancreatitis (CP) aims to relieve pain by draining the main pancreatic duct (MPD) and to treat loco-regional complications...
  11. Sah R, Pannala R, Chari S, Sugumar A, Clain J, Levy M, et al. Prevalence, diagnosis, and profile of autoimmune pancreatitis presenting with features of acute or chronic pancreatitis. Clin Gastroenterol Hepatol. 2010;8:91-6 pubmed publisher
    Little is known about how many patients with features of acute pancreatitis (AP) or chronic pancreatitis (CP) have autoimmune pancreatitis (AIP); most information comes from case reports...
  12. Charrier A, Brigstock D. Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis. Lab Invest. 2010;90:1179-88 pubmed publisher
    Alcoholic chronic pancreatitis (ACP) is characterized by pancreatic necrosis, inflammation, and scarring, the latter of which is due to excessive collagen deposition by activated pancreatic stellate cells (PSC)...
  13. Santosh D, Lakhtakia S, Gupta R, Reddy D, Rao G, Tandan M, et al. Clinical trial: a randomized trial comparing fluoroscopy guided percutaneous technique vs. endoscopic ultrasound guided technique of coeliac plexus block for treatment of pain in chronic pancreatitis. Aliment Pharmacol Ther. 2009;29:979-84 pubmed publisher
    Coeliac plexus block (CPB) is a management option for pain control in chronic pancreatitis. CPB is conventionally performed by percutaneous technique with fluoroscopic guidance (PCFG)...
  14. Ammann R, Raimondi S, Maisonneuve P, Mullhaupt B. Is obesity an additional risk factor for alcoholic chronic pancreatitis?. Pancreatology. 2010;10:47-53 pubmed publisher
    Obesity is a known risk factor for severe acute pancreatitis (AP). Since alcoholic chronic pancreatitis (ACP) is closely linked to alcoholic AP, overweight before disease onset might impact on incidence and outcome of ACP, and represent ..
  15. Gardner T, Kennedy A, Gelrud A, Banks P, Vege S, Gordon S, et al. Chronic pancreatitis and its effect on employment and health care experience: results of a prospective American multicenter study. Pancreas. 2010;39:498-501 pubmed publisher
    Symptoms of chronic pancreatitis (CP) frequently hinder patients' ability to work. The aim of our study was to evaluate the impact of CP on employment patterns and health care experience...
  16. Stevens T, Lopez R, Adler D, Al Haddad M, Conway J, Dewitt J, et al. Multicenter comparison of the interobserver agreement of standard EUS scoring and Rosemont classification scoring for diagnosis of chronic pancreatitis. Gastrointest Endosc. 2010;71:519-26 pubmed publisher
    EUS has less than optimal interobserver agreement for the diagnosis of chronic pancreatitis. The newly developed Rosemont consensus scoring system includes weighted criteria and stricter definitions for individual features...
  17. Wilcox C, Lopes T. A randomized trial comparing endoscopic stenting to a sham procedure for chronic pancreatitis. Clin Trials. 2009;6:455-63 pubmed publisher
    A number of studies support the use of endoscopically placed pancreatic duct (PD) stents to decrease pain in chronic pancreatitis (CP). Nevertheless, flaws in study design have prevented experts from reaching a consensus...
  18. Okuyama H, Kubota A, Kawahara H, Shimizu Y, Watanabe T, Yamanaka H, et al. Frey procedure for chronic pancreatitis in a child with duodenal atresia and complex pancreaticobiliary disorders. Eur J Pediatr Surg. 2010;20:45-7 pubmed publisher
    ..The Frey procedure can be a safe and effective operation in children with chronic pancreatitis caused by complex pancreatobiliary disorders associated with duodenal atresia.
  19. Moon S, Kim M, Park D, Song T, Eum J, Lee S, et al. Modified fully covered self-expandable metal stents with antimigration features for benign pancreatic-duct strictures in advanced chronic pancreatitis, with a focus on the safety profile and reducing migration. Gastrointest Endosc. 2010;72:86-91 pubmed publisher
    ..has recently been tried in the management of refractory pancreatic-duct strictures associated with advanced chronic pancreatitis. The major limitation of FCSEMSs was frequent migration...
  20. Rosa E Silva L, Troncon L, Gallo L, Foss M, Passos A, Perdoná G, et al. Determinants of accelerated small intestinal transit in alcohol-related chronic pancreatitis. Dig Dis Sci. 2010;55:1017-25 pubmed publisher
    Patients with chronic pancreatitis may have abnormal gastrointestinal transit, but the factors underlying these abnormalities are poorly understood...
  21. Kongkam P, Wagner D, Sherman S, Fogel E, Whittaker S, Watkins J, et al. Intrathecal narcotic infusion pumps for intractable pain of chronic pancreatitis: a pilot series. Am J Gastroenterol. 2009;104:1249-55 pubmed publisher
    ..the efficacy of intrathecal narcotics pump (ITNP) as an alternative treatment for patients with pain from chronic pancreatitis (CP)...
  22. Raimondi S, Lowenfels A, Morselli Labate A, Maisonneuve P, Pezzilli R. Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection. Best Pract Res Clin Gastroenterol. 2010;24:349-58 pubmed publisher
    Acute pancreatitis, chronic pancreatitis and pancreatic cancer are responsible for most of the burden of exocrine pancreatic disease...
  23. Frulloni L, Gabbrielli A, Pezzilli R, Zerbi A, Cavestro G, Marotta F, et al. Chronic pancreatitis: report from a multicenter Italian survey (PanCroInfAISP) on 893 patients. Dig Liver Dis. 2009;41:311-7 pubmed publisher
    No data on chronic pancreatitis in Italy are available yet. To evaluate demographic, clinical, diagnostic and therapeutic aspects in patients suffering from chronic pancreatitis...
  24. Chauhan S, Forsmark C. Pain management in chronic pancreatitis: A treatment algorithm. Best Pract Res Clin Gastroenterol. 2010;24:323-35 pubmed publisher
    Abdominal pain is common and frequently debilitating in patients with chronic pancreatitis. Medical therapy includes abstinence from tobacco and alcohol and the use of analgesics and adjunctive agents...
  25. Gu R, Shampang A, Reilly A, Fisher D, Glass W, Ramsingh A. IL-10 is pathogenic during the development of coxsackievirus B4-induced chronic pancreatitis. Virology. 2009;395:77-86 pubmed publisher
    Using a mouse model of coxsackievirus B4 (CVB4-V)-induced chronic pancreatitis, we investigated whether cytokines are involved in the progression of acute disease to chronic inflammatory disease...
  26. Logsdon C, Ji B. Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer. Clin Gastroenterol Hepatol. 2009;7:S40-3 pubmed publisher
    The relationship between chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) is unclear. CP is a risk factor for PDAC, CP is found within the vicinity of PDAC, and both share many similar genetic alterations...
  27. Catalano M, Sahai A, Levy M, Romagnuolo J, Wiersema M, Brugge W, et al. EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification. Gastrointest Endosc. 2009;69:1251-61 pubmed publisher
    EUS is increasingly used in the diagnosis of chronic pancreatitis (CP)...
  28. Masson E, Paliwal S, Bhaskar S, Prakash S, Scotet V, Reddy D, et al. Genetic analysis of the glycoprotein 2 gene in patients with chronic pancreatitis. Pancreas. 2010;39:353-8 pubmed publisher
    ..was to evaluate whether variations in the glycoprotein 2 gene (GP2) may potentially affect the risk of chronic pancreatitis. Six hundred sixty-one French white patients (idiopathic chronic pancreatitis, n = 590; familial chronic ..
  29. Albashir S, Bronner M, Parsi M, Walsh R, Stevens T. Endoscopic ultrasound, secretin endoscopic pancreatic function test, and histology: correlation in chronic pancreatitis. Am J Gastroenterol. 2010;105:2498-503 pubmed publisher
    ..pancreatic function tests are considered useful, and possibly complementary, in the diagnosis of early chronic pancreatitis (CP). Few past studies have compared either methods with a histological gold standard...
  30. Liggett T, Melnikov A, Yi Q, Replogle C, Brand R, Kaul K, et al. Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis. Cancer. 2010;116:1674-80 pubmed publisher
    Although patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer (PanCa), the timely detection of PanCa often is difficult, because the symptoms of CP and PanCa are very similar...
  31. Ida S, Ohmuraya M, Hirota M, Ozaki N, Hiramatsu S, Uehara H, et al. Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet. Exp Anim. 2010;59:421-9 pubmed
    Although chronic pancreatitis is a risk factor for pancreatic ductal adenocarcinoma (PDA), the relationship between chronic pancreatitis and PDA remains obscure...
  32. Lerch M, Mayerle J, Aghdassi A, Budde C, Nitsche C, Sauter G, et al. Advances in the etiology of chronic pancreatitis. Dig Dis. 2010;28:324-9 pubmed publisher
    In the past, chronic pancreatitis has been regarded as a fairly uniform and largely untreatable disorder that most commonly affects patients who both lack gainful employment or adequate insurance coverage and have a tendency to smoke and ..
  33. Dominguez Munoz J, Iglesias Garcia J. Oral pancreatic enzyme substitution therapy in chronic pancreatitis: is clinical response an appropriate marker for evaluation of therapeutic efficacy?. JOP. 2010;11:158-62 pubmed
    Malnutrition secondary to pancreatic exocrine insufficiency plays a prognostic role in chronic pancreatitis. Enzyme substitution therapy is generally prescribed to avoid diarrhea and weight loss, although it is unknown whether this is ..
  34. Negi S, Singh A, Chaudhary A. Pain relief after Frey's procedure for chronic pancreatitis. Br J Surg. 2010;97:1087-95 pubmed publisher
    ..pain relief after Frey's procedure (local head resection with lateral pancreaticojejunostomy, LR-LPJ) for chronic pancreatitis. This retrospective study evaluated pain control using a validated score and risk factors associated with ..
  35. Sikkens E, Cahen D, Kuipers E, Bruno M. Pancreatic enzyme replacement therapy in chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2010;24:337-47 pubmed publisher
    Exocrine pancreatic insufficiency (EPI) is a serious condition which occurs in several diseases including chronic pancreatitis (CP), cystic fibrosis, pancreatic cancer, and as a result of pancreatic surgery...
  36. Schnitzler C, Mesquita J, Shires R. Cortical and trabecular bone microarchitecture and turnover in alcohol-induced chronic pancreatitis: a histomorphometric study. J Bone Miner Metab. 2010;28:456-67 pubmed publisher
    Alcohol-induced chronic pancreatitis is associated with bone loss, but bone histomorphometric data describing the mechanism of cortical (Ct) and trabecular (Tb) bone loss are scarce...
  37. de Cid R, Ramos M, Aparisi L, Garcia C, Mora J, Estivill X, et al. Independent contribution of common CFTR variants to chronic pancreatitis. Pancreas. 2010;39:209-15 pubmed publisher
    We have assessed whether CFTR gene has a major impact on chronic pancreatitis (CP) pathogenesis than that provided by the CFTR mutations...
  38. Shah N, Makin A, Sheen A, Siriwardena A. Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy. World J Gastroenterol. 2010;16:4066-71 pubmed
    To undertake a baseline study comparing quality of life (QoL) in patients with chronic pancreatitis (CP) on Antox to those with CP, matched for disease duration, who were not on this medication...
  39. Kereszturi E, Kiraly O, Sahin Toth M. Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis. Gut. 2009;58:545-9 pubmed publisher
    ..of the serine protease inhibitor Kazal type 1 (SPINK1) gene have been shown to increase the risk for chronic pancreatitis. A haplotype comprising the c.101A>G (p...
  40. Wang L, Li Z, Li S, Jin Z, Zou D, Chen F. Prevalence and clinical features of chronic pancreatitis in China: a retrospective multicenter analysis over 10 years. Pancreas. 2009;38:248-54 pubmed publisher
    A multicenter study was initiated by the Chinese Chronic Pancreatitis Study Group to determine the nature and magnitude of chronic pancreatitis (CP) in China...
  41. Shu J, Zhang X, Zhao J, Yang L, Zeng N, Zhai Z. DCE-MRI in experimental chronic pancreatitis. Contrast Media Mol Imaging. 2009;4:127-34 pubmed publisher
    To assess pancreatic perfusion in experimental chronic pancreatitis (CP) by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). DCE MRI on a 1.5 T MR scanner was performed on 21 piglets with the ligation of pancreatic duct...
  42. Chen J, Ferec C. Chronic pancreatitis: genetics and pathogenesis. Annu Rev Genomics Hum Genet. 2009;10:63-87 pubmed publisher
    b>Chronic pancreatitis (CP) is a persistent inflammation of the pancreas. Over the past 12 years, genetic studies of hereditary, familial, and idiopathic forms of CP have made great progress in defining the disease pathogenesis...
  43. Ota Y, Masamune A, Inui K, Kume K, Shimosegawa T, Kikuyama M. Phenotypic variability of the homozygous IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene in patients with chronic pancreatitis. Tohoku J Exp Med. 2010;221:197-201 pubmed
    b>Chronic pancreatitis (CP) is a progressive inflammatory disease that eventually results in the impairment of exocrine and endocrine functions of the pancreas...
  44. Kaufman M, Singh G, Das S, Concha Parra R, Erber J, Micames C, et al. Efficacy of endoscopic ultrasound-guided celiac plexus block and celiac plexus neurolysis for managing abdominal pain associated with chronic pancreatitis and pancreatic cancer. J Clin Gastroenterol. 2010;44:127-34 pubmed publisher
    ..and celiac plexus neurolysis (CPN) have become important interventions in the management of pain due to chronic pancreatitis and pancreatic cancer...
  45. Midha S, Khajuria R, Shastri S, Kabra M, Garg P. Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations. Gut. 2010;59:800-7 pubmed publisher
    To study the genetic predisposition, phenotype and prognosis of idiopathic chronic pancreatitis (CP). Prospective observational and case-control study. Tertiary care academic centre. Consecutive patients with CP...
  46. Kloppel G, Adsay N. Chronic pancreatitis and the differential diagnosis versus pancreatic cancer. Arch Pathol Lab Med. 2009;133:382-7 pubmed publisher
    Distinguishing chronic pancreatitis from pancreatic ductal adenocarcinoma (PDAC) is a well-known challenge, at both the clinical and the morphologic level. To focus on the histopathologic findings that are diagnostic or suggestive of PDAC...
  47. Ceyhan G, Demir I, Maak M, Friess H. Fate of nerves in chronic pancreatitis: Neural remodeling and pancreatic neuropathy. Best Pract Res Clin Gastroenterol. 2010;24:311-22 pubmed publisher
    ..characterized by concomitant local, intra-organ and central neuropathic and neuroplastic alterations as chronic pancreatitis (CP)...
  48. Dominguez Munoz J. Diagnosis of chronic pancreatitis: Functional testing. Best Pract Res Clin Gastroenterol. 2010;24:233-41 pubmed publisher
    The diagnosis of chronic pancreatitis is mainly based on imaging procedures (e.g., endoscopic ultrasound, magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI))...
  49. Demir I, Ceyhan G, Rauch U, Altintas B, Klotz M, Muller M, et al. The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity. Neurogastroenterol Motil. 2010;22:480-90, e112-3 pubmed publisher
    Pancreatic neuropathy in chronic pancreatitis (CP) and pancreatic cancer (PCa) is characterized by pancreatic neuropathy, i.e. increased neural density and hypertrophy, which are associated with neuropathic pain...
  50. Puli S, Reddy J, Bechtold M, Antillon M, Brugge W. EUS-guided celiac plexus neurolysis for pain due to chronic pancreatitis or pancreatic cancer pain: a meta-analysis and systematic review. Dig Dis Sci. 2009;54:2330-7 pubmed publisher
    The objective of this study was to evaluate the efficacy of EUS-guided CPN for pain relief in patients with chronic pancreatitis and pancreatic cancer...
  51. Chang W, Kim B, Lee J, Kang P, Lee K, Lee K, et al. The clinical and radiological characteristics of focal mass-forming autoimmune pancreatitis: comparison with chronic pancreatitis and pancreatic cancer. Pancreas. 2009;38:401-8 pubmed publisher
    ..These patients were distinguished into 8 FMF AIP patients and 15 ordinary chronic pancreatitis patients through a histological review, along with considering the immunoglobulin G4 staining...
  52. van Loo E, van Baal M, Gooszen H, Ploeg R, Nieuwenhuijs V. Long-term quality of life after surgery for chronic pancreatitis. Br J Surg. 2010;97:1079-86 pubmed publisher
    Surgery for chronic pancreatitis is indicated for intractable pain or the treatment of complications...
  53. Feng Q, Wang W, Feng X, Mei X, Zhu C, Liu Z, et al. Astrocytic activation in thoracic spinal cord contributes to persistent pain in rat model of chronic pancreatitis. Neuroscience. 2010;167:501-9 pubmed publisher
    One of the most important symptoms in chronic pancreatitis (CP) is constant and recurrent abdominal pain. However, there is still no ideal explanation and treatment on it...
  54. Olesen S, Brock C, Krarup A, Funch Jensen P, Arendt Nielsen L, Wilder Smith O, et al. Descending inhibitory pain modulation is impaired in patients with chronic pancreatitis. Clin Gastroenterol Hepatol. 2010;8:724-30 pubmed publisher
    Pain is a prominent symptom in chronic pancreatitis (CP), but the underlying mechanisms are incompletely understood...
  55. Li Z, Wang W, Liao Z, Zou D, Jin Z, Chen J, et al. A long-term follow-up study on endoscopic management of children and adolescents with chronic pancreatitis. Am J Gastroenterol. 2010;105:1884-92 pubmed publisher
    Data on therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for chronic pancreatitis (CP) in children and adolescents, especially with long-term follow-up of consequences, are rarely reported...
  56. Bournet B, Souque A, Senesse P, Assenat E, Barthet M, Lesavre N, et al. Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis. Endoscopy. 2009;41:552-7 pubmed publisher
    Differential diagnosis between pancreatic adenocarcinoma (PADC) and pseudotumoral forms of chronic pancreatitis remains difficult. Mutation of KRAS oncogene is present in 75% to 95% of PADC...
  57. Rosendahl J, Ronai Z, Kovacs P, Teich N, Wittenburg H, Bluher M, et al. Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis. Pancreatology. 2010;10:165-72 pubmed publisher
    ..Because increased trypsinogen autoactivation has been implicated as a pathogenic mechanism in chronic pancreatitis, we hypothesized that genetic variants of TPST2 might alter the risk for the disease...
  58. Schrader H, Menge B, Belyaev O, Uhl W, Schmidt W, Meier J. Amino acid malnutrition in patients with chronic pancreatitis and pancreatic carcinoma. Pancreas. 2009;38:416-21 pubmed publisher
    b>Chronic pancreatitis (CP) and pancreatic cancer (CA) have been associated with intestinal malabsorption and inflammation. However, little is known about the changes in amino acid metabolism in such patients...
  59. Mroczko B, Groblewska M, Gryko M, Kędra B, Szmitkowski M. Diagnostic usefulness of serum interleukin 6 (IL-6) and C-reactive protein (CRP) in the differentiation between pancreatic cancer and chronic pancreatitis. J Clin Lab Anal. 2010;24:256-61 pubmed publisher
    ..the diagnostic usefulness of pretreatment serum levels of IL-6 and CRP to differentiate between PC and chronic pancreatitis (CP) patients...
  60. Shimosegawa T, Kume K, Satoh K. Chronic pancreatitis and pancreatic cancer: prediction and mechanism. Clin Gastroenterol Hepatol. 2009;7:S23-8 pubmed publisher
    We investigated the SPINK 1 mutations in 156 sporadic pancreatic cancer (PCa), and 8 pancreatic cancer with chronic pancreatitis (CPPCa) patients, and in 527 healthy subjects. The results demonstrated that 3 of 8 patients with CPPCa (37...
  61. Schmitz Winnenthal H, Pietsch D, Schimmack S, Bonertz A, Udonta F, Ge Y, et al. Chronic pancreatitis is associated with disease-specific regulatory T-cell responses. Gastroenterology. 2010;138:1178-88 pubmed publisher
    b>Chronic pancreatitis is characterized by alternating phases of acute inflammation and quiescent disease. Involvement of T-cell responses has been suggested, but pancreatitis-specific T cells have not been described...
  62. Witt H, Rosendahl J, Te Morsche R, Santhosh S, Chacko A, Schulz H, et al. Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis. Pancreas. 2010;39:188-92 pubmed publisher
    ..Genetic alterations of different pancreatic zymogens or their inhibitors have been associated with chronic pancreatitis (CP). We sequenced all 12 GP2 exons in 380 German CP patients and in 182 German control subjects...