cystectomy

Summary

Summary: Used for excision of the urinary bladder.

Top Publications

  1. ncbi Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients
    J P Stein
    Department of Urology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    J Clin Oncol 19:666-75. 2001
  2. ncbi Causes of increased hospital stay after radical cystectomy in a clinical pathway setting
    Sam S Chang
    Departments of Urologic Surgery and Patient Care Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Urol 167:208-11. 2002
  3. ncbi Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer
    H Barton Grossman
    M D Anderson Cancer Center, Houston, USA
    N Engl J Med 349:859-66. 2003
  4. ncbi Bladder cancer
    Donald S Kaufman
    Department of Medicine, the Claire and John Bertucci Center for Genitourinary Cancers, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 374:239-49. 2009
  5. ncbi Prognostic role and HER2 expression of circulating tumor cells in peripheral blood of patients prior to radical cystectomy: a prospective study
    Michael Rink
    Department of Urology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 61:810-7. 2012
  6. ncbi Laparoscopic radical cystectomy with orthotopic ileal neobladder for bladder cancer: oncologic results of 171 cases with a median 3-year follow-up
    Jian Huang
    Department of Urology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou 510120, PR China
    Eur Urol 58:442-9. 2010
  7. ncbi Analysis of early complications after radical cystectomy: results of a collaborative care pathway
    Sam S Chang
    Department of Urologic Surgery and Patient Care Services, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
    J Urol 167:2012-6. 2002
  8. ncbi Gum chewing stimulates bowel motility in patients undergoing radical cystectomy with urinary diversion
    Erik J Kouba
    Division of Urologic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Urology 70:1053-6. 2007
  9. ncbi Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Urol 176:2414-22; discussion 2422. 2006
  10. ncbi Laparoscopic versus open radical cystectomy for the management of bladder cancer: mid-term oncological outcome
    U Syn Ha
    Department of Urology, The Catholic University of Korea, College of Medicine, Seoul, Korea
    Int J Urol 17:55-61. 2010

Detail Information

Publications352 found, 100 shown here

  1. ncbi Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients
    J P Stein
    Department of Urology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    J Clin Oncol 19:666-75. 2001
    To evaluate our long-term experience with patients treated uniformly with radical cystectomy and pelvic lymph node dissection for invasive bladder cancer and to describe the association of the primary bladder tumor stage and regional ..
  2. ncbi Causes of increased hospital stay after radical cystectomy in a clinical pathway setting
    Sam S Chang
    Departments of Urologic Surgery and Patient Care Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Urol 167:208-11. 2002
    Our institution targets postoperative days 6 to 8 for discharge home after radical cystectomy. We examined this population to determine the causes of increased hospital stay and risk factors that may predict prolonged hospitalization.
  3. ncbi Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer
    H Barton Grossman
    M D Anderson Cancer Center, Houston, USA
    N Engl J Med 349:859-66. 2003
    ..We evaluated the ability of neoadjuvant chemotherapy to improve the outcome in patients with locally advanced bladder cancer who were treated with radical cystectomy.
  4. ncbi Bladder cancer
    Donald S Kaufman
    Department of Medicine, the Claire and John Bertucci Center for Genitourinary Cancers, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 374:239-49. 2009
    ..We discuss bladder preserving approaches, combination chemotherapy including new agents, targeted therapies, and advances in molecular biology...
  5. ncbi Prognostic role and HER2 expression of circulating tumor cells in peripheral blood of patients prior to radical cystectomy: a prospective study
    Michael Rink
    Department of Urology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 61:810-7. 2012
    ..Preliminary research has suggested the potential prognostic value of circulating tumor cells (CTC) in patients with advanced nonmetastatic urothelial carcinoma of the bladder (UCB)...
  6. ncbi Laparoscopic radical cystectomy with orthotopic ileal neobladder for bladder cancer: oncologic results of 171 cases with a median 3-year follow-up
    Jian Huang
    Department of Urology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou 510120, PR China
    Eur Urol 58:442-9. 2010
    Radical cystectomy (RC) with pelvic lymph node dissection (PLND) is the standard treatment for muscle-invasive and high-risk non-muscle-invasive bladder cancer (BCa)...
  7. ncbi Analysis of early complications after radical cystectomy: results of a collaborative care pathway
    Sam S Chang
    Department of Urologic Surgery and Patient Care Services, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
    J Urol 167:2012-6. 2002
    We examined our recent series of patients who underwent radical cystectomy to determine and analyze the early perioperative morbidity of the procedure in a contemporary series treated with the guidance of a clinical pathway.
  8. ncbi Gum chewing stimulates bowel motility in patients undergoing radical cystectomy with urinary diversion
    Erik J Kouba
    Division of Urologic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Urology 70:1053-6. 2007
    ..Because urinary diversion typically uses a segment of bowel, it is conceivable that patients undergoing cystectomy and diversion may benefit from gum chewing...
  9. ncbi Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Urol 176:2414-22; discussion 2422. 2006
    We present the characteristics and outcomes of a large, contemporary, consecutive series of patients treated with radical cystectomy and pelvic lymphadenectomy for transitional cell carcinoma of the bladder.
  10. ncbi Laparoscopic versus open radical cystectomy for the management of bladder cancer: mid-term oncological outcome
    U Syn Ha
    Department of Urology, The Catholic University of Korea, College of Medicine, Seoul, Korea
    Int J Urol 17:55-61. 2010
    To compare the mid-term oncological outcome of laparoscopic radical cystectomy (LRC) with those of open radical cystectomy (ORC).
  11. ncbi Radical cystectomy for bladder cancer today--a homogeneous series without neoadjuvant therapy
    Stephan Madersbacher
    Department of Urology, University of Bern, Anna Seiler Haus, CH 3010 Bern, Switzerland
    J Clin Oncol 21:690-6. 2003
    To investigate the effect of pelvic lymph node dissection and radical cystectomy for transitional cell cancer of the bladder on recurrence-free and overall survival, pelvic recurrences, and metastatic patterns in a homogeneous group.
  12. ncbi Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy
    Wei Chen
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Epidemiol Biomarkers Prev 18:400-8. 2009
    ..Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in urothelial carcinoma of the bladder (UC) are unclear...
  13. ncbi Prognostic value of neutrophil-to-lymphocyte ratio and establishment of novel preoperative risk stratification model in bladder cancer patients treated with radical cystectomy
    Tatsuo Gondo
    Department of Urology, Tokyo Medical University, Tokyo, Japan
    Urology 79:1085-91. 2012
    ..factors, including neutrophil-to-lymphocyte ratio (NLR), and to develop a novel prognostic factors-based risk stratification model for disease-specific survival (DSS) in bladder cancer patients treated with radical cystectomy (RC).
  14. ncbi ICUD-EAU International Consultation on Bladder Cancer 2012: Radical cystectomy and bladder preservation for muscle-invasive urothelial carcinoma of the bladder
    Georgios Gakis
    Department of Urology, University Hospital Tuebingen, Germany
    Eur Urol 63:45-57. 2013
    ..New guidelines of the International Consultation on Urological Diseases for the treatment of muscle-invasive bladder cancer (MIBC) have recently been published...
  15. ncbi ICUD-EAU International Consultation on Bladder Cancer 2012: Urinary diversion
    Richard E Hautmann
    University of Ulm, Germany
    Eur Urol 63:67-80. 2013
    A summary of the 2nd International Consultation on Bladder Cancer recommendations on the reconstructive options after radical cystectomy (RC), their outcomes, and their complications.
  16. ncbi Analysis of sex differences in cancer-specific survival and perioperative mortality following radical cystectomy: results of a large German multicenter study of nearly 2500 patients with urothelial carcinoma of the bladder
    Wolfgang Otto
    Department of Urology, Caritas St Josef Medical Centre, University of Regensburg, Landshuterstrasse 65, Regensburg, Germany
    Gend Med 9:481-9. 2012
    ..Although overall incidence is higher in men, cancer-specific survival (CSS) has been suggested to be lower in women. Although the former effect is attributed to greater exposure to carcinogens in men, the latter has not been elucidated...
  17. ncbi Laparoendoscopic single-site radical cystectomy and pelvic lymph node dissection: initial experience and 2-year follow-up
    Jihad H Kaouk
    Section of Laparoscopic and Robotic Surgery, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Urology 76:857-61. 2010
    To report the first series of laparoendoscopic single-site surgery for radical cystectomy and bilateral pelvic lymph node dissection...
  18. ncbi Radical cystectomy in patients older than 75 years: assessment of morbidity and mortality
    X Game
    Department of Urology and Andrology, Rangueil University Hospital, Toulouse, France
    Eur Urol 39:525-9. 2001
    ..reviewed our surgical experience to assess intra- and postoperative morbidity and mortality in 25 patients 75 years old or older with invasive bladder cancer who underwent radical cystectomy and urinary diversion or bladder substitution.
  19. ncbi Health related quality of life assessment after radical cystectomy: comparison of ileal conduit with continent orthotopic neobladder
    Sajal C Dutta
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Urol 168:164-7. 2002
    ..Therefore, we compared health related quality of life in patients who underwent neobladder versus ileal conduit creation using validated questionnaires...
  20. ncbi Quality of life issues in bladder cancer patients following cystectomy and urinary diversion
    Michael P Porter
    Department of Urology, University of Washington, H220 Health Sciences Center, Box 357183, Seattle, WA 98195 7183, USA
    Urol Clin North Am 32:207-16. 2005
    HRQOL outcomes in bladder cancer patients undergoing cystectomy and urinary diversion are an important component in the critical assessment of bladder cancer treatment. To date, understanding of HRQOL in these patients remains poor...
  21. ncbi Discrepancy between clinical and pathologic stage: impact on prognosis after radical cystectomy
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Eur Urol 51:137-49; discussion 149-51. 2007
    We compared clinical and pathologic staging in a large, contemporary, consecutive series of patients who were treated with radical cystectomy and pelvic lymphadenectomy, and determined the effect of stage discrepancy on outcomes.
  22. ncbi Current perioperative management of radical cystectomy with intestinal urinary reconstruction for muscle-invasive bladder cancer and reduction of the incidence of postoperative ileus
    Massimo Maffezzini
    Struttura Complessa di Urologia, E O Ospedali Galliera, Mura delle Cappuccine, 14 16128 Genova, Italy
    Surg Oncol 17:41-8. 2008
    Major abdominal surgery, and also radical cystectomy, is followed by a delayed return of bowel function attributable to postoperative ileus (POI), which, in addition, stands out as one of the most frequent complications that causes ..
  23. ncbi Combined-modality treatment and selective organ preservation in invasive bladder cancer: long-term results
    Claus Rodel
    Department of Radiation Oncology, Institute of Pathology, University of Erlangen, Germany
    J Clin Oncol 20:3061-71. 2002
    ..To evaluate our long-term experience with combined modality treatment and selective bladder preservation and to identify factors that may predict treatment response, risk of relapse, and survival...
  24. ncbi Radical cystectomy in the elderly: comparison of clincal outcomes between younger and older patients
    Peter E Clark
    Department of Urology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Cancer 104:36-43. 2005
    The authors report their experience with radical cystectomy for transitional cell carcinoma (TCC) of the bladder comparing clinical outcomes, including complication rates, among older patients versus younger patients in a high-volume ..
  25. pmc Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy
    Luciana Schultz
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer 116:5517-26. 2010
    ..Identifying novel molecular prognostic factors and targets of therapy is crucial. Mammalian target of rapamycin (mTOR) pathway plays a pivotal role in establishing cell shape, migration, and proliferation...
  26. ncbi Quality of life aspects of bladder cancer: a review of the literature
    M F Botteman
    Abt Associates Clinical Trials, Bethesda, MD, USA
    Qual Life Res 12:675-88. 2003
    ....
  27. ncbi Perioperative complications of radical cystectomy in a contemporary series
    Vladimir Novotny
    Department of Urology, Technical University, Dresden, Germany
    Eur Urol 51:397-401; discussion 401-2. 2007
    Radical cystectomy is the preferred standard treatment for patients with muscle-invasive bladder cancer. With improvements in intra- and perioperative care lower complication rates have been reported...
  28. ncbi Radical cystectomy for invasive bladder cancer: long-term results of a standard procedure
    John P Stein
    Department of Urology, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90098, USA
    World J Urol 24:296-304. 2006
    Radical cystectomy with an appropriate lymphadenectomy remains the standard of therapy for high-grade invasive bladder cancer...
  29. ncbi Radical cystectomy with extended lymphadenectomy: evaluating separate package versus en bloc submission for node positive bladder cancer
    John P Stein
    Department of Urology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90089, USA
    J Urol 177:876-81; discussion 881-2. 2007
    To provide future mapping analysis of lymph node positive disease we modified our lymphadenectomy at radical cystectomy for bladder cancer from an en bloc packet to 13 separate nodal packets...
  30. ncbi High expression of karyopherin-α2 defines poor prognosis in non-muscle-invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy
    Jørgen Bjerggaard Jensen
    Department of Urology, Aarhus University Hospital, Skejby, Denmark
    Eur Urol 59:841-8. 2011
    ..Conventional clinicopathologic risk factors have failed to accurately predict the prognosis of patients with bladder cancer (BC)...
  31. ncbi p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer
    Shahrokh F Shariat
    Scott Department of Urology, Baylor College of Medicine, 6560 Fannin, Suite 2100, Houston, TX 77030, USA
    J Clin Oncol 22:1014-24. 2004
    ..To determine whether p53, p21, pRB, and/or p16 expression is associated with bladder cancer stage, progression, and prognosis...
  32. ncbi Perioperative outcomes with laparoscopic radical cystectomy: "pure laparoscopic" and "open-assisted laparoscopic" approaches
    Georges Pascal Haber
    Section of Laparoscopic and Robotic Surgery, Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 70:910-5. 2007
    Techniques for laparoscopic radical cystectomy are rapidly evolving...
  33. ncbi Comparison of hand-assisted laparoscopic and open radical cystectomy for bladder cancer
    Sheng zheng Wang
    Department of Urology, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, PR China
    Urol Int 84:28-33. 2010
    To present our experience of hand-assisted laparoscopic radical cystectomy (HALRC) and compare it with open radical cystectomy (ORC).
  34. ncbi International validation of the prognostic value of lymphovascular invasion in patients treated with radical cystectomy
    Shahrokh F Shariat
    University of Texas Southwestern Medical Center, Dallas, Texas, USA
    BJU Int 105:1402-12. 2010
    To externally validate the prognostic value of lymphovascular invasion (LVI) in a large international cohort of patients treated with radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).
  35. ncbi Comparative analysis of laparoscopic and robot-assisted radical cystectomy with ileal conduit urinary diversion
    Jose Benito A Abraham
    Department of Urology, University of California at Irvine, Orange, California 92868, USA
    J Endourol 21:1473-80. 2007
    To compare our experience with laparoscopic radical cystectomy (LACIC) and robot-assisted laparoscopic radical cystectomy (RACIC) with ileal conduit urinary diversion.
  36. ncbi Complications following radical cystectomy for bladder cancer in the elderly
    Michael Froehner
    Department of Urology, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Eur Urol 56:443-54. 2009
    ..increasing life expectancy and the increasing proportion of elderly people in the general population, radical cystectomy will be considered for a growing number of elderly patients who suffer from muscle-invasive or recurrent bladder ..
  37. ncbi Laparoscopic partial cystectomy with en bloc resection of the urachus for urachal adenocarcinoma
    Sung Hoo Hong
    Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Int J Urol 14:963-5. 2007
    ..The preferred treatment is wide local excision with partial or radical cystectomy. Two patients who presented with urachal carcinoma underwent laparoscopic partial cystectomy with en bloc ..
  38. ncbi Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease
    Vitaly Margulis
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Clin Cancer Res 12:7369-73. 2006
    ..Methods: Immunohistochemical staining for Ki-67 was done on serial cuts from tissue microarrays containing cystectomy specimens from 9 patients without bladder cancer and 226 consecutive patients with bladder TCC...
  39. ncbi Laparoscopic radical cystectomy for cancer: oncological outcomes at up to 5 years
    Georges Pascal Haber
    Section of Laparoscopic and Robotic Surgery, Glickman Urological Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BJU Int 100:137-42. 2007
    To report the oncological outcomes at < or = 5 years after laparoscopic radical cystectomy (LRC), as open RC is the reference standard treatment for muscle-invasive bladder cancer, but interest in LRC is increasing at selected centres ..
  40. ncbi Prospective evaluation of a preoperative biomarker panel for prediction of upstaging at radical cystectomy
    Shahrokh F Shariat
    Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria
    BJU Int 113:70-6. 2014
    ..a panel of biomarkers could identify patients with organ-confined disease likely to be upstaged at radical cystectomy (RC), as retrospective studies have found that cell-cycle- and proliferation-related biomarkers can help improve ..
  41. ncbi Associations between comorbidity, and overall survival and bladder cancer specific survival after radical cystectomy: results from the Alberta Urology Institute Radical Cystectomy database
    Adrian S Fairey
    Division of Urology, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Urol 182:85-92; discussion 93. 2009
    We determined the associations between comorbidity, and overall survival and bladder cancer specific survival after radical cystectomy.
  42. ncbi Similar treatment outcomes for radical cystectomy and radical radiotherapy in invasive bladder cancer treated at a United Kingdom specialist treatment center
    Sanjeev Kotwal
    Pyrah Department of Urology, St James s University Hospital, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    Int J Radiat Oncol Biol Phys 70:456-63. 2008
    ..To conduct a retrospective analysis within a large university teaching hospital, comparing outcomes between patients receiving either radical surgery or radiotherapy as curative treatment for bladder cancer...
  43. ncbi Preoperative plasma soluble E-cadherin predicts metastases to lymph nodes and prognosis in patients undergoing radical cystectomy
    Kazumasa Matsumoto
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Urol 170:2248-52. 2003
    ..We determined whether plasma levels of sE-cadherin are associated with bladder cancer stage and prognosis...
  44. ncbi Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer: its association with clinical characteristics and survival after cystectomy
    Ichiya Homma
    Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 100:2331-4. 2009
    ..significance of HLA class I molecules in muscle-invasive bladder cancer patients who underwent radical cystectomy. Immunohistochemical staining for HLA class I molecules with monoclonal antibody EMR 8-5 was performed on ..
  45. ncbi The significance of lymphovascular invasion in transurethral resection of bladder tumour and cystectomy specimens on the survival of patients with urothelial bladder cancer
    Necole M Streeper
    Department of Urology, University of Iowa, Iowa City, IA 52242 1089, USA
    BJU Int 103:475-9. 2009
    ..evidence of lymphovascular invasion (LVI) in their transurethral resection of bladder tumour (TURBT) and radical cystectomy (RC) specimens would have a worse prognosis and higher likelihood of clinical understaging, and to assess the ..
  46. ncbi Characteristics and outcomes of patients with clinical carcinoma in situ only treated with radical cystectomy: an international study of 243 patients
    Derya Tilki
    Ludwig Maximilians Universitat Munchen, Klinikum Grosshadern, Munich, Germany
    J Urol 183:1757-63. 2010
    We describe the rate of up staging and the cancer specific outcomes of patients with carcinoma in situ refractory to transurethral resection with intravesical therapy treated with radical cystectomy.
  47. ncbi Long-term results of selective partial cystectomy for invasive urothelial bladder carcinoma
    Marc C Smaldone
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Urology 72:613-6. 2008
    We reviewed our experience with partial cystectomy to assess local control and survival rates, and to identify pathologic predictors for recurrence.
  48. ncbi Improving selection of appropriate urinary diversion following radical cystectomy for bladder cancer
    Siamak Daneshmand
    Norris Comprehensive Cancer Center, USC Institute of Urology, 1441 Eastlake Ave, Suite 7416, CA 90089, USA
    Expert Rev Anticancer Ther 11:941-8. 2011
    Radical cystectomy represents the gold-standard of treatment for invasive bladder cancer. Following cystectomy, various options for urinary diversion may be offered to patients...
  49. ncbi Female gender and carcinoma in situ in the prostatic urethra are prognostic factors for recurrence, progression, and disease-specific mortality in T1G3 bladder cancer patients treated with bacillus Calmette-Guérin
    Joan Palou
    Department of Urology, Fundacio Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur Urol 62:118-25. 2012
    ..Controversy exists over the most important prognostic factors in T1 high-grade non-muscle-invasive bladder cancer (NMIBC) patients treated with bacillus Calmette-Guérin (BCG)...
  50. ncbi Risk stratification of organ confined bladder cancer after radical cystectomy using cell cycle related biomarkers
    Shahrokh F Shariat
    Department of Urology, Weill Cornell Medical Center, New York, NY, USA
    J Urol 187:457-62. 2012
    We tested whether assessing the expression of cell cycle related proteins (p53, pRB, p21 and p27) could predict clinical outcomes after radical cystectomy in patients with organ confined urothelial carcinoma of the bladder.
  51. ncbi Prospective evaluation of a molecular marker panel for prediction of recurrence and cancer-specific survival after radical cystectomy
    Yair Lotan
    Department of Urology, University of Texas Southwestern Medical Center Dallas, TX 75390, USA
    Eur Urol 64:465-71. 2013
    ..that cell cycle-related and proliferation biomarkers add information to standard pathologic tumor features after radical cystectomy (RC). There are no prospective studies validating the clinical utility of markers in bladder cancer.
  52. ncbi Cystectomy for bladder cancer: a contemporary series
    G Dalbagni
    Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    J Urol 165:1111-6. 2001
    ..MATERIALS AND METHODS: The pathological material and medical records of 300 patients treated with cystectomy were reviewed, and the new TNM classification was adopted...
  53. ncbi A randomized prospective trial to assess the impact of transurethral resection in narrow band imaging modality on non-muscle-invasive bladder cancer recurrence
    Angelo Naselli
    Department of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur Urol 61:908-13. 2012
    ..NBI cystoscopy can increase bladder cancer (BCa) visualization and detection at the time of transurethral resection (TUR). NBI may therefore reduce subsequent relapse following TUR...
  54. ncbi [Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines]
    A Stenzl
    Servicio de Urologia, Universidad Eberhard KarlsTuebingen, Alemania
    Actas Urol Esp 36:449-60. 2012
    ..New data regarding treatment of muscle-invasive and metastatic bladder cancer (MiM-BC) has emerged and led to an update of the European Association of Urology (EAU) guidelines for MiM-BC...
  55. ncbi Psychometric characteristics of a condition-specific, health-related quality-of-life survey: the FACT-Vanderbilt Cystectomy Index
    Christopher B Anderson
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
    Urology 80:77-83. 2012
    Radical cystectomy (RC) for bladder cancer can be associated with significant morbidity and alterations in health-related quality of life (HRQOL)...
  56. ncbi Predictors of cancer-specific mortality after disease recurrence following radical cystectomy
    Michael Rink
    Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10065, USA
    BJU Int 111:E30-6. 2013
    ..add? Outcomes after disease recurrence in patients with urothelial carcinoma of the bladder treated with radical cystectomy are variable, but the majority of patients die from the disease within 2 years after disease recurrence...
  57. ncbi Tissue-engineered tubular graft for urinary diversion after radical cystectomy in rabbits
    Wenbiao Liao
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China
    J Surg Res 182:185-91. 2013
    ..Tissue engineering technology may offer an alternative method for urinary diversion after radical cystectomy. In this study, we aimed to make a tissue-engineered tubular graft (TETG) using bladder epithelial cells and ..
  58. ncbi Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy
    Evanguelos Xylinas
    Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA
    Eur J Cancer 49:1889-97. 2013
    To investigate the impact of variant histologies of urothelial carcinoma of the bladder (UCB) on oncologic outcomes after radical cystectomy (RC).
  59. ncbi The role of laparoscopic and robotic cystectomy in the management of muscle-invasive bladder cancer with special emphasis on cancer control and complications
    Ben J Challacombe
    The Urology Centre, Guy s and Thomas NHS Foundation Trust and KCL, London, UK
    Eur Urol 60:767-75. 2011
    Minimally invasive radical cystectomy (MIRC) techniques for the treatment of muscle-invasive bladder cancer (BCa) are being increasingly applied...
  60. ncbi Increased EZH2 protein expression is associated with invasive urothelial carcinoma of the bladder
    Hang Wang
    Department of Urology, James Buchanan Brady Urological Institute, Baltimore, MD 21287, USA
    Urol Oncol 30:428-33. 2012
    ..We examined EZH2 protein expression levels in bladder tissue specimens from patients with urothelial carcinoma (UC) and investigated the relationship between EZH2 protein expression and clinical outcomes...
  61. ncbi Radical cystectomy in patients aged > or = 75 years: an updated review of patients treated with curative and palliative intent
    Nikola Zebic
    Department of Urology Kliniken Essen Mitte, Essen, Germany
    BJU Int 95:1211-4. 2005
    To evaluate the morbidity and mortality of radical cystectomy in a group of unselected patients aged > or = 75 years who were treated with curative and palliative intent.
  62. pmc Use of radical cystectomy for patients with invasive bladder cancer
    John L Gore
    Department of Urology, University of Washington School of Medicine, 1959 NE Pacific St, Box 356510, Seattle, WA 98195, USA
    J Natl Cancer Inst 102:802-11. 2010
    Evidence-based guidelines recommend radical cystectomy for patients with muscle-invasive bladder cancer. However, many patients receive alternate therapies, such as chemotherapy or radiation...
  63. ncbi Comparison of surgical stress response to laparoscopic and open radical cystectomy
    Sheng zheng Wang
    Department of Urology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
    World J Urol 28:451-5. 2010
    To prospectively compare stress response to laparoscopic and open radical cystectomy by the measurement of humoral mediators and the incidence of systemic inflammatory response syndrome (SIRS).
  64. ncbi Clinicopathological outcomes after radical cystectomy for clinical T2 urothelial carcinoma: further evidence to support the use of neoadjuvant chemotherapy
    Daniel Canter
    Departments of Urologic Oncology, Medical Oncology and Biostatistics, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 107:58-62. 2011
    To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC).
  65. ncbi Lessons learned from 1,000 neobladders: the 90-day complication rate
    Richard E Hautmann
    Department of Urology, University of Ulm, Ulm, Germany
    J Urol 184:990-4; quiz 1235. 2010
    We report the 90-day morbidity of the ileal neobladder in a large, contemporary, homogenous series of patients who underwent radical cystectomy at a tertiary academic referral center using a standard approach.
  66. ncbi Early oncological outcomes for bladder urothelial carcinoma patients treated with robotic-assisted radical cystectomy
    Eric C Kauffman
    Department of Urology, New York Presbyterian Hospital Weill Cornell Medical Center, New York, NY, USA
    BJU Int 107:628-35. 2011
    To determine oncological outcomes including early survival rates among unselected bladder urothelial carcinoma (BUC) patients treated with robotic-assisted radical cystectomy (RRC).
  67. ncbi Discrepancy between clinical and pathological stage: external validation of the impact on prognosis in an international radical cystectomy cohort
    Robert S Svatek
    University of Texas Health Science Center San Antonio, San Antonio, TX, USA
    BJU Int 107:898-904. 2011
    ..To compare the clinical and pathologic stage among a large, multi-institutional series of patients undergoing radical and to determine the effect of stage discrepancy on outcomes...
  68. ncbi Long-term complications of conduit urinary diversion
    Mark S Shimko
    Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota, USA
    J Urol 185:562-7. 2011
    ..We evaluated long-term surgical complications and clinical outcomes in a large group of patients treated with conduit urinary diversion...
  69. ncbi The management of urethral transitional cell carcinoma after radical cystectomy for invasive bladder cancer
    Peter E Clark
    Department of Urology, University of Southern California Norris Cancer Center, Los Angeles, California, USA
    J Urol 172:1342-7. 2004
    Previous reports have identified risk factors for urethral recurrence following radical cystectomy for transitional cell carcinoma (TCC). However, reports of the clinical presentation, treatment and outcome in these patients are lacking...
  70. ncbi Health-related quality of life after radical cystectomy for bladder cancer in elderly patients with an ileal conduit, ureterocutaneostomy, or orthotopic urinary reservoir: a comparative questionnaire survey
    Takashi Saika
    Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 61:199-203. 2007
    To compare the health-related quality of life of elderly patients after radical cystectomy for bladder cancer in urinary diversion groups: ileal conduit, ureterocutaneostomy, or orthotopic urinary reservoir...
  71. ncbi Bladder cancer
    Lester S Borden
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Oncol 17:275-80. 2005
    ..A brief overview of all aspects of bladder cancer including the etiology, diagnosis, and treatment are discussed with a focus on recent advances...
  72. ncbi Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Cancer 112:315-25. 2008
    ..cancer biomarkers (p53, pRB, p21, p27, and cyclin E1) could improve the ability to predict disease recurrence and cancer-specific survival after radical cystectomy in patients with pTa-3N0M0 urothelial carcinoma of the bladder (UCB).
  73. ncbi Clinical outcomes after sexuality preserving cystectomy and neobladder (prostate sparing cystectomy) in 44 patients
    J A Nieuwenhuijzen
    Department of Urology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    J Urol 173:1314-7. 2005
    We describe the functional outcome on erectile function, continence and voiding, and local and distant cancer recurrence rates in 44 patients after sexuality preserving cystectomy and neobladder (prostate sparing cystectomy).
  74. ncbi Muscle-invasive urothelial carcinoma of the bladder
    S Bruce Malkowicz
    Department of Urology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Urology 69:3-16. 2007
    ..In those patients who undergo surgery, clinical pathways may streamline care. Radical cystectomy remains the "gold standard" of therapy, providing 5-year survival rates of 75% to 80% in patients with ..
  75. ncbi Quality of life after cystectomy and urinary diversion: an evidence based analysis
    Elmar W Gerharz
    Department of Urology, Julius Maximilians University Medical School EWG, Wurzburg, Germany
    J Urol 174:1729-36. 2005
    We critically examined the evidence supporting the widely accepted notion that patients undergoing continent urinary tract reconstruction after cystectomy experience superior quality of life outcomes than patients receiving a conduit.
  76. ncbi Prognostic significance of Her2/neu overexpression in patients with muscle invasive urinary bladder cancer treated with radical cystectomy
    Surendra B Kolla
    Department of Urology, All India Institute of Medical Sciences, New Delhi 110029, India
    Int Urol Nephrol 40:321-7. 2008
    The aim of the study was to evaluate the status of Her2/neu protein expression in patients with muscle-invasive urothelial carcinomas of the bladder treated with radical cystectomy and to determine its prognostic significance.
  77. ncbi Impact of transurethral resection of bladder tumor: analysis of cystectomy specimens to evaluate for residual tumor
    Sang Eun Lee
    Department of Urology, Seoul National University College of Medicine, Seoul, South Korea
    Urology 63:873-7; discussion 877. 2004
    To analyze the impact of transurethral resection of bladder tumor (TURBT) on the outcome of patients with bladder cancer who undergo subsequent cystectomy.
  78. ncbi Quality of life after cystectomy and orthotopic neobladder versus ileal conduit urinary diversion
    A Hobisch
    Department of Urology, University of Innsbruck, Austria
    World J Urol 18:338-44. 2000
    ..A total of 102 patients who underwent cystectomy due to a bladder malignancy were included in the study. In 69 patients (67...
  79. ncbi When should quality of life be measured after radical cystectomy?
    Haluk Kulaksizoglu
    Department of Urology, SSK Istanbul Teaching Hospital, 11 Kisim Zambak Apt Daire 4 Ataköy, 34750 Istanbul, Turkey
    Eur Urol 42:350-5. 2002
    ..In this prospective study our aim was to establish the time it takes cystectomized patients' to adapt to their new health status...
  80. ncbi Stage pT0 at radical cystectomy confers improved survival: an international study of 4,430 patients
    Derya Tilki
    Department of Urology, Ludwig Maximilians University Munich, Klinikum Grosshadern, Munich, Germany
    J Urol 184:888-94. 2010
    We describe the cancer related outcome in patients with pT0 bladder urothelial carcinoma at radical cystectomy who did not receive preoperative chemotherapy in a large multicenter series...
  81. ncbi p53 predictive value for pT1-2 N0 disease at radical cystectomy
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA
    J Urol 182:907-13. 2009
    ..of patients with pT1-2N0M0 urothelial carcinoma of the bladder experience disease progression despite radical cystectomy with curative intent...
  82. ncbi Association of procedure volume with radical cystectomy outcomes in a nationwide database
    Christopher E Barbieri
    Department of Urologic Surgery and Center for Clinical Improvement, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
    J Urol 178:1418-21; discussion 1421-2. 2007
    Studies of national databases yield important information about expected outcomes after radical cystectomy and factors that influence patient morbidity and mortality...
  83. pmc Effect of preoperative nutritional deficiency on mortality after radical cystectomy for bladder cancer
    Justin R Gregg
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Urol 185:90-6. 2011
    ..We evaluated the effect of preoperative nutritional deficiency on perioperative mortality and overall survival in patients undergoing radical cystectomy for bladder cancer.
  84. ncbi Characteristics and outcomes of patients with pT4 urothelial carcinoma at radical cystectomy: a retrospective international study of 583 patients
    Derya Tilki
    Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Urol 183:87-93. 2010
    We describe cancer specific outcomes in patients with pT4 bladder urothelial carcinoma at radical cystectomy in a large international cohort.
  85. ncbi Long-term outcomes of selective bladder preservation by combined-modality therapy for invasive bladder cancer: the MGH experience
    Jason A Efstathiou
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Eur Urol 61:705-11. 2012
    Whether organ-conserving treatment by combined-modality therapy (CMT) achieves comparable long-term survival to radical cystectomy (RC) for muscle-invasive bladder cancer (BCa) is largely unknown.
  86. ncbi Inflammatory pseudotumor and sarcoma of urinary bladder: differential diagnosis and outcome in thirty-eight spindle cell neoplasms
    K A Iczkowski
    Department of Pathology and Laboratory Medicine, University of Florida and Veterans Administration Medical Center, Gainesville, Florida 32608 1197, USA
    Mod Pathol 14:1043-51. 2001
    ..Two of four experienced tumor recurrence after partial cystectomy (2 and 26 months)...
  87. ncbi Neoadjuvant systemic therapy or early cystectomy? Single-center analysis of outcomes after therapy for patients with clinically localized micropapillary urothelial carcinoma of the bladder
    Islam A Ghoneim
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Urology 77:867-70. 2011
    ..MPBC is a rare variant of urothelial carcinoma with aggressive clinical behavior. Radical cystectomy is considered the standard approach for treatment of patients with localized disease; however, the role of ..
  88. ncbi Lymphadenectomy with cystectomy: is it necessary and what is its extent?
    Mohamed A Ghoneim
    Urology and Nephrology Center, Gomhouria Street, Mansoura, Dakahlia 35516, Egypt
    Eur Urol 46:457-61. 2004
  89. ncbi Preservation of prostate during radical cystectomy: evaluation of prevalence of prostate cancer associated with bladder cancer
    A Ruffion
    Urologie Lyon Sud, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Urology 65:703-7. 2005
    ..To estimate the frequency and characteristics of prostatic lesions discovered incidentally in radical cystoprostatectomy specimens and to determine whether any factors would allow for the detection of prostate cancer preoperatively...
  90. ncbi A comparison of postoperative complications in open versus robotic cystectomy
    Casey K Ng
    Weill Cornell Medical College, Department of Urology, New York, NY, USA
    Eur Urol 57:274-81. 2010
    Robotic cystectomy is an emerging alternative for treatment of invasive bladder cancer (BCa). However, reduction in postoperative morbidity relative to the open approach has not been demonstrated.
  91. ncbi Second-line intravesical therapy versus cystectomy for bacille Calmette-Guérin (BCG) failures
    Fadi N Joudi
    Department of Urology, University of Iowa, Iowa City, 200 Hawkins Drive, IA 52242, USA
    Curr Opin Urol 14:271-5. 2004
    ..To give an update on the new modalities in treating patients with superficial bladder cancer who have failed bacille Calmette-Guérin...
  92. ncbi Extracapsular extension of pelvic lymph node metastases from urothelial carcinoma of the bladder is an independent prognostic factor
    Achim Fleischmann
    Department of Urology, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    J Clin Oncol 23:2358-65. 2005
    ..To analyze the prognostic impact of risk factors for urothelial carcinoma of the bladder (UCB) with pelvic lymph node (LN) metastases...
  93. ncbi Effect of a minimum lymph node policy in radical cystectomy and pelvic lymphadenectomy on lymph node yields, lymph node positivity rates, lymph node density, and survivorship in patients with bladder cancer
    Andrea C Fang
    Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA
    Cancer 116:1901-8. 2010
    Extended pelvic lymphadenectomy (PLND) during radical cystectomy (RC) reportedly improves bladder cancer-specific survival. Lymph node counts are often a proxy for the extensiveness of a dissection...
  94. ncbi Health-related quality of life after radical cystectomy for bladder cancer: a comparison of ileal conduit and orthotopic bladder replacement
    I Hara
    Department of Urology, Kobe University School of Medicine, Kobe, Japan
    BJU Int 89:10-3. 2002
    To compare the health-related quality of life (HRQoL) after radical cystectomy in patients with an ileal conduit or an orthotopic neobladder.
  95. ncbi The association between extent of lymphadenectomy and survival among patients with lymph node metastases undergoing radical cystectomy
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Cancer 112:2401-8. 2008
    Long-term survival in patients with lymph node-positive bladder cancer who undergo cystectomy suggests a therapeutic role for lymphadenectomy...
  96. ncbi Standardization of pelvic lymphadenectomy performed at radical cystectomy: can we establish a minimum number of lymph nodes that should be removed?
    Theresa M Koppie
    Department of Urology, Sidney Kimmel Center for Urologic Cancer, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 107:2368-74. 2006
    The number of lymph nodes (LNs) removed during radical cystectomy (RC) for transitional cell carcinoma (TCC) of the bladder affects overall and disease-specific survival, but no consensus exists regarding the minimum number of LNs that ..
  97. ncbi Radical cystectomy and lymphadenectomy for invasive bladder cancer: towards the evolution of an optimal surgical standard
    Ganesh V Raj
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Oncol 34:110-21. 2007
    ..A growing body of evidence indicates that the quality of radical cystectomy (RC) directly affects patient outcome...
  98. ncbi Pathology of the prostate in radical cystectomy specimens: a critical review
    Riccardo Autorino
    Clinica Urologica, Seconda Universita degli Studi, Napoli, Italy
    Surg Oncol 18:73-84. 2009
    ..The reported incidence of prostate adenocarcinoma in cystectomy specimens is highly variable and mostly depending on the histopathology technique of sampling...
  99. ncbi Health related quality of life after radical cystectomy: comparison of ileal conduit to continent orthotopic neobladder
    R Autorino
    Clinica Urologica, AOU Policlinico, Seconda Universita degli Studi, Napoli, Italy
    Eur J Surg Oncol 35:858-64. 2009
    ..To compare health related quality of life (HRQOL) between patients with two different types of urinary diversion, ileal conduit and orthotopic neobladder, and between them and an age-matched population of healthy subjects...
  100. ncbi Urinary diversions after cystectomy: the association of clinical factors, complications and functional results of four different diversions
    Jakko A Nieuwenhuijzen
    Department of Urology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Eur Urol 53:834-42; discussion 842-4. 2008
    We present a single institute experience of the four most widely used diversions after cystectomy in 281 patients, with an evaluation of the association between clinical factors, complication rates, functional results, and metabolic ..
  101. ncbi Clinicopathologic features of prostate adenocarcinoma incidentally discovered at the time of radical cystectomy: an evidence-based analysis
    Rocco Damiano
    Clinica Urologica, Università Magna Graecia, Catanzaro, Italy
    Eur Urol 52:648-57. 2007
    To review all relevant features of incidentally discovered prostate cancer (PCa) in patients undergoing radical cystectomy for bladder cancer: incidence, pathologic characteristics, clinical significance, and implications for its ..

Research Grants33

  1. Novel IL-15 Superagonist Therapy for Bladder Cancer
    Hing C Wong; Fiscal Year: 2011
    ..Of these, 30 percent will eventually die of bladder cancer and 50 percent will undergo radical cystectomy. Thus, a novel therapy, either as first-line or salvage therapy, is desperately needed for NMIBC to prevent ..
  2. Real-time multiphoton microscopy of periprostatic tissue architecture
    Ashutosh K Tewari; Fiscal Year: 2010
    ..This technology may also be extended to other nerve-sparing pelvic oncologic surgeries, eg. radical cystectomy, extirpative colorectal and gynaecologic pelvic procedures, and retroperitoneal lymph node dissection...
  3. Open vs Robot-Assisted Radical Cystectomy: A Randomized Trial
    Dipen Parekh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Open Radical Cystectomy (ORC) is currently the gold standard treatment for muscle-invasive bladder cancer...
  4. Intra-bladder MMC &suramin for nonmuscle-invading &locally advanced bladder ca
    Ze Lu; Fiscal Year: 2012
    ..The second group, the muscle-invading tumors, is managed by partial or complete cystectomy (removal of bladder), which presents significant risks and is not well-tolerated by older patients...
  5. Novel Studies of Bladder Regeneration in a Rodent Model
    George Christ; Fiscal Year: 2009
    ..and man shares several common features, we propose novel studies of bladder regeneration following subtotal cystectomy in a rodent model...
  6. Combination chemo-siRNA gene therapy of nonmuscle-invading bladder cancer
    Ze Lu; Fiscal Year: 2012
    ..The second group, the muscle-invading tumors, is managed by partial or complete cystectomy (removal of bladder), which presents significant risks and is not well tolerated by older patients...
  7. Optical Imaging of Bladder Cancer with Molecular Contrast Agents
    Joseph C Liao; Fiscal Year: 2013
    ..e. radical cystectomy)...
  8. Urinary Diversion Among Bladder Cancer Survivors: Cost, Complications, and QOL
    CARMIT KURN MCMULLEN; Fiscal Year: 2013
    ..Each year 7,000 people with bladder cancer in the United States have cystectomy surgery (bladder removal)...
  9. Investigation of a nanoparticle albumin-bound mTOR inhibitor, nab-rapamycin for t
    Neil Desai; Fiscal Year: 2013
    ..have been explored in the second-line setting with only limited efficacy, forcing many patients into a radical cystectomy. Because of high disease recurrence and morbidity, the cost per bladder cancer patient is among the highest of ..
  10. Anti-Tumor Mechanisms and Therapeutic Effects of Vitamin D
    Donald L Trump; Fiscal Year: 2013
    ..trial, the effect of calcitriol (phase I dose, D1, 2), cisplatin (75mg/m2, D2 every 28days) and gemcitabine (800mg/m2, D2 weekly) for 3 cycles before cystectomy in muscle-invading transitional cell bladder cancer.
  11. Evaluation of a novel urothelial cancer biomarker of lethality
    JONATHAN ERIC ROSENBERG; Fiscal Year: 2013
    ..g. early cystectomy for non-invasive UC). This work will provide the foundation for future studies to develop the 1q23...
  12. DT-EGF Toxic Fusion Protein for Treatment of Bladder Cancer
    Mike Glodé; Fiscal Year: 2012
    ..resection and BCG administration is unsuccessful in about 40% of cases with recurrences that eventually require cystectomy or other aggressive therapy...
  13. Immunotherapeutic minicells for use in intermediate and high-risk non-muscle inva
    ROGER ALLEN SABBADINI; Fiscal Year: 2013
    ..or BCG-relapsed (together 45-50%) and for those patients that are BCG-intolerant (~20%) is immediate cystectomy and urinary diversion, which exacts a heavy toll in the form of acute and chronic morbidity, we feel major ..
  14. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2006
    ..associated with an increased chance of progression in patients with organ-confined TCC managed by radical cystectomy. Our hypothesis is that p53 alterations organ-confined TCC of the bladder significantly increase the risk of ..
  15. PHARMACODYNAMICS OF AGENTS FOR BLADDER CANCER THERAPY
    JESSIE AU; Fiscal Year: 2003
    ..in vivo using bladders removed from dogs and from patients who receive drug instillation at the time of total cystectomy. This will indicate whether effective drug concentrations are achieved at the tumor sites. A.3...
  16. REGENERATION OF FUNCTIONAL SMOOTH MUSCLE TISSUE
    Emil Tanagho; Fiscal Year: 2004
    ..matrix bladder when grafted to the host bladder (normal, diabetic and interstitial cystitis) after partial cystectomy. These growth factors will stimulate the process of ingrowth of smooth muscle, urothelial lining, ..
  17. A COMPARISON OF IN VIVO AND VITRO TISSUE ENGINEERING
    Bradley Kropp; Fiscal Year: 2004
    ..Using the canine subtotal cystectomy model, animals will undergo urinary bladder augmentations utilizing unseeded PAP and SIS (in vivo technology) ..
  18. TREATMENT AND PREVENTION OF IMPOTENCE
    Tom Lue; Fiscal Year: 1990
    ..2. Intraoperative neurostimulation in patients undergoing radical cystectomy or radical prostatectomy for cancer of the bladder and prostate. 3...
  19. PHARMACOLOGY OF NEW INTRAVESICAL THERAPEUTICS
    Trevor Sweatman; Fiscal Year: 1992
    ..to human disease, urothelial drug penetration will be studied in a limited series of patients undergoing total cystectomy for advanced bladder carcinoma, with results compared to data obtained in animal studies...
  20. PHARMACODYNAMICS OF AGENTS FOR BLADDER CANCER
    JESSIE AU; Fiscal Year: 1991
    ..of the bladder and the depth of drug penetration in vivo using bladders removed from patients who receive total cystectomy shortly after drug instillation. 3...
  21. P53 GENE THERAPY FOR LOCALLY ADVANCED BLADDER CANCER
    Lance Pagliaro; Fiscal Year: 2000
    DESCRIPTION: (Applicant's Abstract) The standard treatment for muscle- invasive bladder cancer is cystectomy. Though often curative, this is a mutilating procedure and its effects on quality of life are unacceptable to many patients...
  22. BLADDER CANCER--SUPPESSOR GENES AND RADIATION RESPONSE
    Chi Wei Lin; Fiscal Year: 1993
    ..This has required clinicians to recommend cystectomy, with its associated major losses of genitourinary function, to patients with muscle-invading tumors even though ..
  23. BIOMARKERS FOR BLADDER CANCER CHEMOPREVENTION TRIALS
    Walter Stadler; Fiscal Year: 1999
    ..b>Cystectomy is generally required for muscle invasive disease...
  24. Chemoprevention of murine urinary bladder carcinogenesis
    Ashish Kamat; Fiscal Year: 2005
    ..abstract_text> ..
  25. Validation of Medicare Claims to Define Chemotherapy Use
    Deborah Schrag; Fiscal Year: 2005
    ..This knowledge has the potential to lay the groundwork for development of an inexpensive and efficient system for monitoring and improving the quality of US cancer care. ..
  26. hAR Alterations and Androgen-Independent Prostate Cancer
    Ralph de Vere White; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. COLUMBIA UNIVERSITY SOUTHWEST ONCOLOGY GROUP PROGRAM
    Daniel Petrylak; Fiscal Year: 2003
    ..Based on substantial laboratory strength, we intend to integrate Columbia laboratory resources as core support for SWOG clinical studies. ..
  28. Neurotrophins and Tyrosine Kinases in Prostate Cancer
    Christopher Evans; Fiscal Year: 2006
    ..This proposal is based on significant preliminary data and has strong translational potential for future proposals. ..
  29. TUMT verses Medical Therapy in Treatment of BPH
    E Crawford; Fiscal Year: 2005
    ..The PI has enlisted the support of consultants who will assist in this important evaluation. The results of this analysis will be critical in allocating health care resources. ..
  30. PARADIGM OF MULTISTEP URINARY BLADDER CARCINOGENESIS
    Bogdan Czerniak; Fiscal Year: 2006
    ....
  31. Methodology of Phase I and II trials of anticancer CAM
    Andrew Vickers; Fiscal Year: 2004
    ....
  32. FUNCTIONS OF DIFFERENT P53 MUTATIONS IN PROSTATE CANCER
    Ralph deVere White; Fiscal Year: 2004
    ..The results obtained during the period of this grant proposal will form the basis for future studies that should affect treatment strategies for this disease. ..
  33. Yeast Assay for p53 Molecular Analysis in Bladder Cancer
    Ralph deVere White; Fiscal Year: 2005
    ..The archival-based yeast functional assay technology will be used in testing bladder cancer specimens (cystectomy and TURBT) and then comparing their p53 status to patient clinical outcomes...