Genomes and Genes
Summary: Used for excision of the urinary bladder.
Publications352 found, 100 shown here
- Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patientsJ P Stein
Department of Urology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
J Clin Oncol 19:666-75. 2001To evaluate our long-term experience with patients treated uniformly with radical cystectomy and pelvic lymph node dissection for invasive bladder cancer and to describe the association of the primary bladder tumor stage and regional ..
- Causes of increased hospital stay after radical cystectomy in a clinical pathway settingSam S Chang
Departments of Urologic Surgery and Patient Care Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Urol 167:208-11. 2002Our institution targets postoperative days 6 to 8 for discharge home after radical cystectomy. We examined this population to determine the causes of increased hospital stay and risk factors that may predict prolonged hospitalization.
- Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancerH Barton Grossman
M D Anderson Cancer Center, Houston, USA
N Engl J Med 349:859-66. 2003..We evaluated the ability of neoadjuvant chemotherapy to improve the outcome in patients with locally advanced bladder cancer who were treated with radical cystectomy.
- Bladder cancerDonald S Kaufman
Department of Medicine, the Claire and John Bertucci Center for Genitourinary Cancers, Massachusetts General Hospital, Boston, MA 02114, USA
Lancet 374:239-49. 2009..We discuss bladder preserving approaches, combination chemotherapy including new agents, targeted therapies, and advances in molecular biology...
- Prognostic role and HER2 expression of circulating tumor cells in peripheral blood of patients prior to radical cystectomy: a prospective studyMichael Rink
Department of Urology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Eur Urol 61:810-7. 2012..Preliminary research has suggested the potential prognostic value of circulating tumor cells (CTC) in patients with advanced nonmetastatic urothelial carcinoma of the bladder (UCB)...
- Laparoscopic radical cystectomy with orthotopic ileal neobladder for bladder cancer: oncologic results of 171 cases with a median 3-year follow-upJian Huang
Department of Urology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou 510120, PR China
Eur Urol 58:442-9. 2010Radical cystectomy (RC) with pelvic lymph node dissection (PLND) is the standard treatment for muscle-invasive and high-risk non-muscle-invasive bladder cancer (BCa)...
- Analysis of early complications after radical cystectomy: results of a collaborative care pathwaySam S Chang
Department of Urologic Surgery and Patient Care Services, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
J Urol 167:2012-6. 2002We examined our recent series of patients who underwent radical cystectomy to determine and analyze the early perioperative morbidity of the procedure in a contemporary series treated with the guidance of a clinical pathway.
- Gum chewing stimulates bowel motility in patients undergoing radical cystectomy with urinary diversionErik J Kouba
Division of Urologic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Urology 70:1053-6. 2007..Because urinary diversion typically uses a segment of bowel, it is conceivable that patients undergoing cystectomy and diversion may benefit from gum chewing...
- Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research ConsortiumShahrokh F Shariat
Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Urol 176:2414-22; discussion 2422. 2006We present the characteristics and outcomes of a large, contemporary, consecutive series of patients treated with radical cystectomy and pelvic lymphadenectomy for transitional cell carcinoma of the bladder.
- Laparoscopic versus open radical cystectomy for the management of bladder cancer: mid-term oncological outcomeU Syn Ha
Department of Urology, The Catholic University of Korea, College of Medicine, Seoul, Korea
Int J Urol 17:55-61. 2010To compare the mid-term oncological outcome of laparoscopic radical cystectomy (LRC) with those of open radical cystectomy (ORC).
- Radical cystectomy for bladder cancer today--a homogeneous series without neoadjuvant therapyStephan Madersbacher
Department of Urology, University of Bern, Anna Seiler Haus, CH 3010 Bern, Switzerland
J Clin Oncol 21:690-6. 2003To investigate the effect of pelvic lymph node dissection and radical cystectomy for transitional cell cancer of the bladder on recurrence-free and overall survival, pelvic recurrences, and metastatic patterns in a homogeneous group.
- Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomyWei Chen
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Cancer Epidemiol Biomarkers Prev 18:400-8. 2009..Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in urothelial carcinoma of the bladder (UC) are unclear...
- Prognostic value of neutrophil-to-lymphocyte ratio and establishment of novel preoperative risk stratification model in bladder cancer patients treated with radical cystectomyTatsuo Gondo
Department of Urology, Tokyo Medical University, Tokyo, Japan
Urology 79:1085-91. 2012..factors, including neutrophil-to-lymphocyte ratio (NLR), and to develop a novel prognostic factors-based risk stratification model for disease-specific survival (DSS) in bladder cancer patients treated with radical cystectomy (RC).
- ICUD-EAU International Consultation on Bladder Cancer 2012: Radical cystectomy and bladder preservation for muscle-invasive urothelial carcinoma of the bladderGeorgios Gakis
Department of Urology, University Hospital Tuebingen, Germany
Eur Urol 63:45-57. 2013..New guidelines of the International Consultation on Urological Diseases for the treatment of muscle-invasive bladder cancer (MIBC) have recently been published...
- ICUD-EAU International Consultation on Bladder Cancer 2012: Urinary diversionRichard E Hautmann
University of Ulm, Germany
Eur Urol 63:67-80. 2013A summary of the 2nd International Consultation on Bladder Cancer recommendations on the reconstructive options after radical cystectomy (RC), their outcomes, and their complications.
- Analysis of sex differences in cancer-specific survival and perioperative mortality following radical cystectomy: results of a large German multicenter study of nearly 2500 patients with urothelial carcinoma of the bladderWolfgang Otto
Department of Urology, Caritas St Josef Medical Centre, University of Regensburg, Landshuterstrasse 65, Regensburg, Germany
Gend Med 9:481-9. 2012..Although overall incidence is higher in men, cancer-specific survival (CSS) has been suggested to be lower in women. Although the former effect is attributed to greater exposure to carcinogens in men, the latter has not been elucidated...
- Laparoendoscopic single-site radical cystectomy and pelvic lymph node dissection: initial experience and 2-year follow-upJihad H Kaouk
Section of Laparoscopic and Robotic Surgery, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
Urology 76:857-61. 2010To report the first series of laparoendoscopic single-site surgery for radical cystectomy and bilateral pelvic lymph node dissection...
- Radical cystectomy in patients older than 75 years: assessment of morbidity and mortalityX Game
Department of Urology and Andrology, Rangueil University Hospital, Toulouse, France
Eur Urol 39:525-9. 2001..reviewed our surgical experience to assess intra- and postoperative morbidity and mortality in 25 patients 75 years old or older with invasive bladder cancer who underwent radical cystectomy and urinary diversion or bladder substitution.
- Health related quality of life assessment after radical cystectomy: comparison of ileal conduit with continent orthotopic neobladderSajal C Dutta
Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Urol 168:164-7. 2002..Therefore, we compared health related quality of life in patients who underwent neobladder versus ileal conduit creation using validated questionnaires...
- Quality of life issues in bladder cancer patients following cystectomy and urinary diversionMichael P Porter
Department of Urology, University of Washington, H220 Health Sciences Center, Box 357183, Seattle, WA 98195 7183, USA
Urol Clin North Am 32:207-16. 2005HRQOL outcomes in bladder cancer patients undergoing cystectomy and urinary diversion are an important component in the critical assessment of bladder cancer treatment. To date, understanding of HRQOL in these patients remains poor...
- Discrepancy between clinical and pathologic stage: impact on prognosis after radical cystectomyShahrokh F Shariat
Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
Eur Urol 51:137-49; discussion 149-51. 2007We compared clinical and pathologic staging in a large, contemporary, consecutive series of patients who were treated with radical cystectomy and pelvic lymphadenectomy, and determined the effect of stage discrepancy on outcomes.
- Current perioperative management of radical cystectomy with intestinal urinary reconstruction for muscle-invasive bladder cancer and reduction of the incidence of postoperative ileusMassimo Maffezzini
Struttura Complessa di Urologia, E O Ospedali Galliera, Mura delle Cappuccine, 14 16128 Genova, Italy
Surg Oncol 17:41-8. 2008Major abdominal surgery, and also radical cystectomy, is followed by a delayed return of bowel function attributable to postoperative ileus (POI), which, in addition, stands out as one of the most frequent complications that causes ..
- Combined-modality treatment and selective organ preservation in invasive bladder cancer: long-term resultsClaus Rodel
Department of Radiation Oncology, Institute of Pathology, University of Erlangen, Germany
J Clin Oncol 20:3061-71. 2002..To evaluate our long-term experience with combined modality treatment and selective bladder preservation and to identify factors that may predict treatment response, risk of relapse, and survival...
- Radical cystectomy in the elderly: comparison of clincal outcomes between younger and older patientsPeter E Clark
Department of Urology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Cancer 104:36-43. 2005The authors report their experience with radical cystectomy for transitional cell carcinoma (TCC) of the bladder comparing clinical outcomes, including complication rates, among older patients versus younger patients in a high-volume ..
- Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomyLuciana Schultz
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cancer 116:5517-26. 2010..Identifying novel molecular prognostic factors and targets of therapy is crucial. Mammalian target of rapamycin (mTOR) pathway plays a pivotal role in establishing cell shape, migration, and proliferation...
- Quality of life aspects of bladder cancer: a review of the literatureM F Botteman
Abt Associates Clinical Trials, Bethesda, MD, USA
Qual Life Res 12:675-88. 2003....
- Perioperative complications of radical cystectomy in a contemporary seriesVladimir Novotny
Department of Urology, Technical University, Dresden, Germany
Eur Urol 51:397-401; discussion 401-2. 2007Radical cystectomy is the preferred standard treatment for patients with muscle-invasive bladder cancer. With improvements in intra- and perioperative care lower complication rates have been reported...
- Radical cystectomy for invasive bladder cancer: long-term results of a standard procedureJohn P Stein
Department of Urology, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90098, USA
World J Urol 24:296-304. 2006Radical cystectomy with an appropriate lymphadenectomy remains the standard of therapy for high-grade invasive bladder cancer...
- Radical cystectomy with extended lymphadenectomy: evaluating separate package versus en bloc submission for node positive bladder cancerJohn P Stein
Department of Urology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90089, USA
J Urol 177:876-81; discussion 881-2. 2007To provide future mapping analysis of lymph node positive disease we modified our lymphadenectomy at radical cystectomy for bladder cancer from an en bloc packet to 13 separate nodal packets...
- High expression of karyopherin-α2 defines poor prognosis in non-muscle-invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomyJørgen Bjerggaard Jensen
Department of Urology, Aarhus University Hospital, Skejby, Denmark
Eur Urol 59:841-8. 2011..Conventional clinicopathologic risk factors have failed to accurately predict the prognosis of patients with bladder cancer (BC)...
- p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancerShahrokh F Shariat
Scott Department of Urology, Baylor College of Medicine, 6560 Fannin, Suite 2100, Houston, TX 77030, USA
J Clin Oncol 22:1014-24. 2004..To determine whether p53, p21, pRB, and/or p16 expression is associated with bladder cancer stage, progression, and prognosis...
- Perioperative outcomes with laparoscopic radical cystectomy: "pure laparoscopic" and "open-assisted laparoscopic" approachesGeorges Pascal Haber
Section of Laparoscopic and Robotic Surgery, Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Urology 70:910-5. 2007Techniques for laparoscopic radical cystectomy are rapidly evolving...
- Comparison of hand-assisted laparoscopic and open radical cystectomy for bladder cancerSheng zheng Wang
Department of Urology, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, PR China
Urol Int 84:28-33. 2010To present our experience of hand-assisted laparoscopic radical cystectomy (HALRC) and compare it with open radical cystectomy (ORC).
- International validation of the prognostic value of lymphovascular invasion in patients treated with radical cystectomyShahrokh F Shariat
University of Texas Southwestern Medical Center, Dallas, Texas, USA
BJU Int 105:1402-12. 2010To externally validate the prognostic value of lymphovascular invasion (LVI) in a large international cohort of patients treated with radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).
- Comparative analysis of laparoscopic and robot-assisted radical cystectomy with ileal conduit urinary diversionJose Benito A Abraham
Department of Urology, University of California at Irvine, Orange, California 92868, USA
J Endourol 21:1473-80. 2007To compare our experience with laparoscopic radical cystectomy (LACIC) and robot-assisted laparoscopic radical cystectomy (RACIC) with ileal conduit urinary diversion.
- Complications following radical cystectomy for bladder cancer in the elderlyMichael Froehner
Department of Urology, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
Eur Urol 56:443-54. 2009..increasing life expectancy and the increasing proportion of elderly people in the general population, radical cystectomy will be considered for a growing number of elderly patients who suffer from muscle-invasive or recurrent bladder ..
- Laparoscopic partial cystectomy with en bloc resection of the urachus for urachal adenocarcinomaSung Hoo Hong
Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea
Int J Urol 14:963-5. 2007..The preferred treatment is wide local excision with partial or radical cystectomy. Two patients who presented with urachal carcinoma underwent laparoscopic partial cystectomy with en bloc ..
- Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined diseaseVitaly Margulis
Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
Clin Cancer Res 12:7369-73. 2006..Methods: Immunohistochemical staining for Ki-67 was done on serial cuts from tissue microarrays containing cystectomy specimens from 9 patients without bladder cancer and 226 consecutive patients with bladder TCC...
- Laparoscopic radical cystectomy for cancer: oncological outcomes at up to 5 yearsGeorges Pascal Haber
Section of Laparoscopic and Robotic Surgery, Glickman Urological Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
BJU Int 100:137-42. 2007To report the oncological outcomes at < or = 5 years after laparoscopic radical cystectomy (LRC), as open RC is the reference standard treatment for muscle-invasive bladder cancer, but interest in LRC is increasing at selected centres ..
- Prospective evaluation of a preoperative biomarker panel for prediction of upstaging at radical cystectomyShahrokh F Shariat
Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria
BJU Int 113:70-6. 2014..a panel of biomarkers could identify patients with organ-confined disease likely to be upstaged at radical cystectomy (RC), as retrospective studies have found that cell-cycle- and proliferation-related biomarkers can help improve ..
- Associations between comorbidity, and overall survival and bladder cancer specific survival after radical cystectomy: results from the Alberta Urology Institute Radical Cystectomy databaseAdrian S Fairey
Division of Urology, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
J Urol 182:85-92; discussion 93. 2009We determined the associations between comorbidity, and overall survival and bladder cancer specific survival after radical cystectomy.
- Similar treatment outcomes for radical cystectomy and radical radiotherapy in invasive bladder cancer treated at a United Kingdom specialist treatment centerSanjeev Kotwal
Pyrah Department of Urology, St James s University Hospital, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Int J Radiat Oncol Biol Phys 70:456-63. 2008..To conduct a retrospective analysis within a large university teaching hospital, comparing outcomes between patients receiving either radical surgery or radiotherapy as curative treatment for bladder cancer...
- Preoperative plasma soluble E-cadherin predicts metastases to lymph nodes and prognosis in patients undergoing radical cystectomyKazumasa Matsumoto
Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
J Urol 170:2248-52. 2003..We determined whether plasma levels of sE-cadherin are associated with bladder cancer stage and prognosis...
- Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer: its association with clinical characteristics and survival after cystectomyIchiya Homma
Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
Cancer Sci 100:2331-4. 2009..significance of HLA class I molecules in muscle-invasive bladder cancer patients who underwent radical cystectomy. Immunohistochemical staining for HLA class I molecules with monoclonal antibody EMR 8-5 was performed on ..
- The significance of lymphovascular invasion in transurethral resection of bladder tumour and cystectomy specimens on the survival of patients with urothelial bladder cancerNecole M Streeper
Department of Urology, University of Iowa, Iowa City, IA 52242 1089, USA
BJU Int 103:475-9. 2009..evidence of lymphovascular invasion (LVI) in their transurethral resection of bladder tumour (TURBT) and radical cystectomy (RC) specimens would have a worse prognosis and higher likelihood of clinical understaging, and to assess the ..
- Characteristics and outcomes of patients with clinical carcinoma in situ only treated with radical cystectomy: an international study of 243 patientsDerya Tilki
Ludwig Maximilians Universitat Munchen, Klinikum Grosshadern, Munich, Germany
J Urol 183:1757-63. 2010We describe the rate of up staging and the cancer specific outcomes of patients with carcinoma in situ refractory to transurethral resection with intravesical therapy treated with radical cystectomy.
- Long-term results of selective partial cystectomy for invasive urothelial bladder carcinomaMarc C Smaldone
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Urology 72:613-6. 2008We reviewed our experience with partial cystectomy to assess local control and survival rates, and to identify pathologic predictors for recurrence.
- Improving selection of appropriate urinary diversion following radical cystectomy for bladder cancerSiamak Daneshmand
Norris Comprehensive Cancer Center, USC Institute of Urology, 1441 Eastlake Ave, Suite 7416, CA 90089, USA
Expert Rev Anticancer Ther 11:941-8. 2011Radical cystectomy represents the gold-standard of treatment for invasive bladder cancer. Following cystectomy, various options for urinary diversion may be offered to patients...
- Female gender and carcinoma in situ in the prostatic urethra are prognostic factors for recurrence, progression, and disease-specific mortality in T1G3 bladder cancer patients treated with bacillus Calmette-GuérinJoan Palou
Department of Urology, Fundacio Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain
Eur Urol 62:118-25. 2012..Controversy exists over the most important prognostic factors in T1 high-grade non-muscle-invasive bladder cancer (NMIBC) patients treated with bacillus Calmette-Guérin (BCG)...
- Risk stratification of organ confined bladder cancer after radical cystectomy using cell cycle related biomarkersShahrokh F Shariat
Department of Urology, Weill Cornell Medical Center, New York, NY, USA
J Urol 187:457-62. 2012We tested whether assessing the expression of cell cycle related proteins (p53, pRB, p21 and p27) could predict clinical outcomes after radical cystectomy in patients with organ confined urothelial carcinoma of the bladder.
- Prospective evaluation of a molecular marker panel for prediction of recurrence and cancer-specific survival after radical cystectomyYair Lotan
Department of Urology, University of Texas Southwestern Medical Center Dallas, TX 75390, USA
Eur Urol 64:465-71. 2013..that cell cycle-related and proliferation biomarkers add information to standard pathologic tumor features after radical cystectomy (RC). There are no prospective studies validating the clinical utility of markers in bladder cancer.
- Cystectomy for bladder cancer: a contemporary seriesG Dalbagni
Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
J Urol 165:1111-6. 2001..MATERIALS AND METHODS: The pathological material and medical records of 300 patients treated with cystectomy were reviewed, and the new TNM classification was adopted...
- A randomized prospective trial to assess the impact of transurethral resection in narrow band imaging modality on non-muscle-invasive bladder cancer recurrenceAngelo Naselli
Department of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Eur Urol 61:908-13. 2012..NBI cystoscopy can increase bladder cancer (BCa) visualization and detection at the time of transurethral resection (TUR). NBI may therefore reduce subsequent relapse following TUR...
- [Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines]A Stenzl
Servicio de Urologia, Universidad Eberhard KarlsTuebingen, Alemania
Actas Urol Esp 36:449-60. 2012..New data regarding treatment of muscle-invasive and metastatic bladder cancer (MiM-BC) has emerged and led to an update of the European Association of Urology (EAU) guidelines for MiM-BC...
- Psychometric characteristics of a condition-specific, health-related quality-of-life survey: the FACT-Vanderbilt Cystectomy IndexChristopher B Anderson
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
Urology 80:77-83. 2012Radical cystectomy (RC) for bladder cancer can be associated with significant morbidity and alterations in health-related quality of life (HRQOL)...
- Predictors of cancer-specific mortality after disease recurrence following radical cystectomyMichael Rink
Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10065, USA
BJU Int 111:E30-6. 2013..add? Outcomes after disease recurrence in patients with urothelial carcinoma of the bladder treated with radical cystectomy are variable, but the majority of patients die from the disease within 2 years after disease recurrence...
- Tissue-engineered tubular graft for urinary diversion after radical cystectomy in rabbitsWenbiao Liao
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China
J Surg Res 182:185-91. 2013..Tissue engineering technology may offer an alternative method for urinary diversion after radical cystectomy. In this study, we aimed to make a tissue-engineered tubular graft (TETG) using bladder epithelial cells and ..
- Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomyEvanguelos Xylinas
Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA
Eur J Cancer 49:1889-97. 2013To investigate the impact of variant histologies of urothelial carcinoma of the bladder (UCB) on oncologic outcomes after radical cystectomy (RC).
- The role of laparoscopic and robotic cystectomy in the management of muscle-invasive bladder cancer with special emphasis on cancer control and complicationsBen J Challacombe
The Urology Centre, Guy s and Thomas NHS Foundation Trust and KCL, London, UK
Eur Urol 60:767-75. 2011Minimally invasive radical cystectomy (MIRC) techniques for the treatment of muscle-invasive bladder cancer (BCa) are being increasingly applied...
- Increased EZH2 protein expression is associated with invasive urothelial carcinoma of the bladderHang Wang
Department of Urology, James Buchanan Brady Urological Institute, Baltimore, MD 21287, USA
Urol Oncol 30:428-33. 2012..We examined EZH2 protein expression levels in bladder tissue specimens from patients with urothelial carcinoma (UC) and investigated the relationship between EZH2 protein expression and clinical outcomes...
- Radical cystectomy in patients aged > or = 75 years: an updated review of patients treated with curative and palliative intentNikola Zebic
Department of Urology Kliniken Essen Mitte, Essen, Germany
BJU Int 95:1211-4. 2005To evaluate the morbidity and mortality of radical cystectomy in a group of unselected patients aged > or = 75 years who were treated with curative and palliative intent.
- Use of radical cystectomy for patients with invasive bladder cancerJohn L Gore
Department of Urology, University of Washington School of Medicine, 1959 NE Pacific St, Box 356510, Seattle, WA 98195, USA
J Natl Cancer Inst 102:802-11. 2010Evidence-based guidelines recommend radical cystectomy for patients with muscle-invasive bladder cancer. However, many patients receive alternate therapies, such as chemotherapy or radiation...
- Comparison of surgical stress response to laparoscopic and open radical cystectomySheng zheng Wang
Department of Urology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
World J Urol 28:451-5. 2010To prospectively compare stress response to laparoscopic and open radical cystectomy by the measurement of humoral mediators and the incidence of systemic inflammatory response syndrome (SIRS).
- Clinicopathological outcomes after radical cystectomy for clinical T2 urothelial carcinoma: further evidence to support the use of neoadjuvant chemotherapyDaniel Canter
Departments of Urologic Oncology, Medical Oncology and Biostatistics, Fox Chase Cancer Center, Philadelphia, PA, USA
BJU Int 107:58-62. 2011To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC).
- Lessons learned from 1,000 neobladders: the 90-day complication rateRichard E Hautmann
Department of Urology, University of Ulm, Ulm, Germany
J Urol 184:990-4; quiz 1235. 2010We report the 90-day morbidity of the ileal neobladder in a large, contemporary, homogenous series of patients who underwent radical cystectomy at a tertiary academic referral center using a standard approach.
- Early oncological outcomes for bladder urothelial carcinoma patients treated with robotic-assisted radical cystectomyEric C Kauffman
Department of Urology, New York Presbyterian Hospital Weill Cornell Medical Center, New York, NY, USA
BJU Int 107:628-35. 2011To determine oncological outcomes including early survival rates among unselected bladder urothelial carcinoma (BUC) patients treated with robotic-assisted radical cystectomy (RRC).
- Discrepancy between clinical and pathological stage: external validation of the impact on prognosis in an international radical cystectomy cohortRobert S Svatek
University of Texas Health Science Center San Antonio, San Antonio, TX, USA
BJU Int 107:898-904. 2011..To compare the clinical and pathologic stage among a large, multi-institutional series of patients undergoing radical and to determine the effect of stage discrepancy on outcomes...
- Long-term complications of conduit urinary diversionMark S Shimko
Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota, USA
J Urol 185:562-7. 2011..We evaluated long-term surgical complications and clinical outcomes in a large group of patients treated with conduit urinary diversion...
- The management of urethral transitional cell carcinoma after radical cystectomy for invasive bladder cancerPeter E Clark
Department of Urology, University of Southern California Norris Cancer Center, Los Angeles, California, USA
J Urol 172:1342-7. 2004Previous reports have identified risk factors for urethral recurrence following radical cystectomy for transitional cell carcinoma (TCC). However, reports of the clinical presentation, treatment and outcome in these patients are lacking...
- Health-related quality of life after radical cystectomy for bladder cancer in elderly patients with an ileal conduit, ureterocutaneostomy, or orthotopic urinary reservoir: a comparative questionnaire surveyTakashi Saika
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
Acta Med Okayama 61:199-203. 2007To compare the health-related quality of life of elderly patients after radical cystectomy for bladder cancer in urinary diversion groups: ileal conduit, ureterocutaneostomy, or orthotopic urinary reservoir...
- Bladder cancerLester S Borden
Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Curr Opin Oncol 17:275-80. 2005..A brief overview of all aspects of bladder cancer including the etiology, diagnosis, and treatment are discussed with a focus on recent advances...
- Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomyShahrokh F Shariat
Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
Cancer 112:315-25. 2008..cancer biomarkers (p53, pRB, p21, p27, and cyclin E1) could improve the ability to predict disease recurrence and cancer-specific survival after radical cystectomy in patients with pTa-3N0M0 urothelial carcinoma of the bladder (UCB).
- Clinical outcomes after sexuality preserving cystectomy and neobladder (prostate sparing cystectomy) in 44 patientsJ A Nieuwenhuijzen
Department of Urology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
J Urol 173:1314-7. 2005We describe the functional outcome on erectile function, continence and voiding, and local and distant cancer recurrence rates in 44 patients after sexuality preserving cystectomy and neobladder (prostate sparing cystectomy).
- Muscle-invasive urothelial carcinoma of the bladderS Bruce Malkowicz
Department of Urology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Urology 69:3-16. 2007..In those patients who undergo surgery, clinical pathways may streamline care. Radical cystectomy remains the "gold standard" of therapy, providing 5-year survival rates of 75% to 80% in patients with ..
- Quality of life after cystectomy and urinary diversion: an evidence based analysisElmar W Gerharz
Department of Urology, Julius Maximilians University Medical School EWG, Wurzburg, Germany
J Urol 174:1729-36. 2005We critically examined the evidence supporting the widely accepted notion that patients undergoing continent urinary tract reconstruction after cystectomy experience superior quality of life outcomes than patients receiving a conduit.
- Prognostic significance of Her2/neu overexpression in patients with muscle invasive urinary bladder cancer treated with radical cystectomySurendra B Kolla
Department of Urology, All India Institute of Medical Sciences, New Delhi 110029, India
Int Urol Nephrol 40:321-7. 2008The aim of the study was to evaluate the status of Her2/neu protein expression in patients with muscle-invasive urothelial carcinomas of the bladder treated with radical cystectomy and to determine its prognostic significance.
- Impact of transurethral resection of bladder tumor: analysis of cystectomy specimens to evaluate for residual tumorSang Eun Lee
Department of Urology, Seoul National University College of Medicine, Seoul, South Korea
Urology 63:873-7; discussion 877. 2004To analyze the impact of transurethral resection of bladder tumor (TURBT) on the outcome of patients with bladder cancer who undergo subsequent cystectomy.
- Quality of life after cystectomy and orthotopic neobladder versus ileal conduit urinary diversionA Hobisch
Department of Urology, University of Innsbruck, Austria
World J Urol 18:338-44. 2000..A total of 102 patients who underwent cystectomy due to a bladder malignancy were included in the study. In 69 patients (67...
- When should quality of life be measured after radical cystectomy?Haluk Kulaksizoglu
Department of Urology, SSK Istanbul Teaching Hospital, 11 Kisim Zambak Apt Daire 4 Ataköy, 34750 Istanbul, Turkey
Eur Urol 42:350-5. 2002..In this prospective study our aim was to establish the time it takes cystectomized patients' to adapt to their new health status...
- Stage pT0 at radical cystectomy confers improved survival: an international study of 4,430 patientsDerya Tilki
Department of Urology, Ludwig Maximilians University Munich, Klinikum Grosshadern, Munich, Germany
J Urol 184:888-94. 2010We describe the cancer related outcome in patients with pT0 bladder urothelial carcinoma at radical cystectomy who did not receive preoperative chemotherapy in a large multicenter series...
- p53 predictive value for pT1-2 N0 disease at radical cystectomyShahrokh F Shariat
Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA
J Urol 182:907-13. 2009..of patients with pT1-2N0M0 urothelial carcinoma of the bladder experience disease progression despite radical cystectomy with curative intent...
- Association of procedure volume with radical cystectomy outcomes in a nationwide databaseChristopher E Barbieri
Department of Urologic Surgery and Center for Clinical Improvement, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
J Urol 178:1418-21; discussion 1421-2. 2007Studies of national databases yield important information about expected outcomes after radical cystectomy and factors that influence patient morbidity and mortality...
- Effect of preoperative nutritional deficiency on mortality after radical cystectomy for bladder cancerJustin R Gregg
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Urol 185:90-6. 2011..We evaluated the effect of preoperative nutritional deficiency on perioperative mortality and overall survival in patients undergoing radical cystectomy for bladder cancer.
- Characteristics and outcomes of patients with pT4 urothelial carcinoma at radical cystectomy: a retrospective international study of 583 patientsDerya Tilki
Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
J Urol 183:87-93. 2010We describe cancer specific outcomes in patients with pT4 bladder urothelial carcinoma at radical cystectomy in a large international cohort.
- Long-term outcomes of selective bladder preservation by combined-modality therapy for invasive bladder cancer: the MGH experienceJason A Efstathiou
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Eur Urol 61:705-11. 2012Whether organ-conserving treatment by combined-modality therapy (CMT) achieves comparable long-term survival to radical cystectomy (RC) for muscle-invasive bladder cancer (BCa) is largely unknown.
- Inflammatory pseudotumor and sarcoma of urinary bladder: differential diagnosis and outcome in thirty-eight spindle cell neoplasmsK A Iczkowski
Department of Pathology and Laboratory Medicine, University of Florida and Veterans Administration Medical Center, Gainesville, Florida 32608 1197, USA
Mod Pathol 14:1043-51. 2001..Two of four experienced tumor recurrence after partial cystectomy (2 and 26 months)...
- Neoadjuvant systemic therapy or early cystectomy? Single-center analysis of outcomes after therapy for patients with clinically localized micropapillary urothelial carcinoma of the bladderIslam A Ghoneim
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
Urology 77:867-70. 2011..MPBC is a rare variant of urothelial carcinoma with aggressive clinical behavior. Radical cystectomy is considered the standard approach for treatment of patients with localized disease; however, the role of ..
- Lymphadenectomy with cystectomy: is it necessary and what is its extent?Mohamed A Ghoneim
Urology and Nephrology Center, Gomhouria Street, Mansoura, Dakahlia 35516, Egypt
Eur Urol 46:457-61. 2004
- Preservation of prostate during radical cystectomy: evaluation of prevalence of prostate cancer associated with bladder cancerA Ruffion
Urologie Lyon Sud, Centre Hospitalier Lyon Sud, Pierre Benite, France
Urology 65:703-7. 2005..To estimate the frequency and characteristics of prostatic lesions discovered incidentally in radical cystoprostatectomy specimens and to determine whether any factors would allow for the detection of prostate cancer preoperatively...
- A comparison of postoperative complications in open versus robotic cystectomyCasey K Ng
Weill Cornell Medical College, Department of Urology, New York, NY, USA
Eur Urol 57:274-81. 2010Robotic cystectomy is an emerging alternative for treatment of invasive bladder cancer (BCa). However, reduction in postoperative morbidity relative to the open approach has not been demonstrated.
- Second-line intravesical therapy versus cystectomy for bacille Calmette-Guérin (BCG) failuresFadi N Joudi
Department of Urology, University of Iowa, Iowa City, 200 Hawkins Drive, IA 52242, USA
Curr Opin Urol 14:271-5. 2004..To give an update on the new modalities in treating patients with superficial bladder cancer who have failed bacille Calmette-Guérin...
- Extracapsular extension of pelvic lymph node metastases from urothelial carcinoma of the bladder is an independent prognostic factorAchim Fleischmann
Department of Urology, University of Bern, Inselspital, CH 3010 Bern, Switzerland
J Clin Oncol 23:2358-65. 2005..To analyze the prognostic impact of risk factors for urothelial carcinoma of the bladder (UCB) with pelvic lymph node (LN) metastases...
- Effect of a minimum lymph node policy in radical cystectomy and pelvic lymphadenectomy on lymph node yields, lymph node positivity rates, lymph node density, and survivorship in patients with bladder cancerAndrea C Fang
Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA
Cancer 116:1901-8. 2010Extended pelvic lymphadenectomy (PLND) during radical cystectomy (RC) reportedly improves bladder cancer-specific survival. Lymph node counts are often a proxy for the extensiveness of a dissection...
- Health-related quality of life after radical cystectomy for bladder cancer: a comparison of ileal conduit and orthotopic bladder replacementI Hara
Department of Urology, Kobe University School of Medicine, Kobe, Japan
BJU Int 89:10-3. 2002To compare the health-related quality of life (HRQoL) after radical cystectomy in patients with an ileal conduit or an orthotopic neobladder.
- The association between extent of lymphadenectomy and survival among patients with lymph node metastases undergoing radical cystectomyJonathan L Wright
Department of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA
Cancer 112:2401-8. 2008Long-term survival in patients with lymph node-positive bladder cancer who undergo cystectomy suggests a therapeutic role for lymphadenectomy...
- Standardization of pelvic lymphadenectomy performed at radical cystectomy: can we establish a minimum number of lymph nodes that should be removed?Theresa M Koppie
Department of Urology, Sidney Kimmel Center for Urologic Cancer, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer 107:2368-74. 2006The number of lymph nodes (LNs) removed during radical cystectomy (RC) for transitional cell carcinoma (TCC) of the bladder affects overall and disease-specific survival, but no consensus exists regarding the minimum number of LNs that ..
- Radical cystectomy and lymphadenectomy for invasive bladder cancer: towards the evolution of an optimal surgical standardGanesh V Raj
Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Semin Oncol 34:110-21. 2007..A growing body of evidence indicates that the quality of radical cystectomy (RC) directly affects patient outcome...
- Pathology of the prostate in radical cystectomy specimens: a critical reviewRiccardo Autorino
Clinica Urologica, Seconda Universita degli Studi, Napoli, Italy
Surg Oncol 18:73-84. 2009..The reported incidence of prostate adenocarcinoma in cystectomy specimens is highly variable and mostly depending on the histopathology technique of sampling...
- Health related quality of life after radical cystectomy: comparison of ileal conduit to continent orthotopic neobladderR Autorino
Clinica Urologica, AOU Policlinico, Seconda Universita degli Studi, Napoli, Italy
Eur J Surg Oncol 35:858-64. 2009..To compare health related quality of life (HRQOL) between patients with two different types of urinary diversion, ileal conduit and orthotopic neobladder, and between them and an age-matched population of healthy subjects...
- Urinary diversions after cystectomy: the association of clinical factors, complications and functional results of four different diversionsJakko A Nieuwenhuijzen
Department of Urology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Eur Urol 53:834-42; discussion 842-4. 2008We present a single institute experience of the four most widely used diversions after cystectomy in 281 patients, with an evaluation of the association between clinical factors, complication rates, functional results, and metabolic ..
- Clinicopathologic features of prostate adenocarcinoma incidentally discovered at the time of radical cystectomy: an evidence-based analysisRocco Damiano
Clinica Urologica, Università Magna Graecia, Catanzaro, Italy
Eur Urol 52:648-57. 2007To review all relevant features of incidentally discovered prostate cancer (PCa) in patients undergoing radical cystectomy for bladder cancer: incidence, pathologic characteristics, clinical significance, and implications for its ..
- Novel IL-15 Superagonist Therapy for Bladder CancerHing C Wong; Fiscal Year: 2011..Of these, 30 percent will eventually die of bladder cancer and 50 percent will undergo radical cystectomy. Thus, a novel therapy, either as first-line or salvage therapy, is desperately needed for NMIBC to prevent ..
- Real-time multiphoton microscopy of periprostatic tissue architectureAshutosh K Tewari; Fiscal Year: 2010..This technology may also be extended to other nerve-sparing pelvic oncologic surgeries, eg. radical cystectomy, extirpative colorectal and gynaecologic pelvic procedures, and retroperitoneal lymph node dissection...
- Open vs Robot-Assisted Radical Cystectomy: A Randomized TrialDipen Parekh; Fiscal Year: 2013DESCRIPTION (provided by applicant): Open Radical Cystectomy (ORC) is currently the gold standard treatment for muscle-invasive bladder cancer...
- Intra-bladder MMC &suramin for nonmuscle-invading &locally advanced bladder caZe Lu; Fiscal Year: 2012..The second group, the muscle-invading tumors, is managed by partial or complete cystectomy (removal of bladder), which presents significant risks and is not well-tolerated by older patients...
- Novel Studies of Bladder Regeneration in a Rodent ModelGeorge Christ; Fiscal Year: 2009..and man shares several common features, we propose novel studies of bladder regeneration following subtotal cystectomy in a rodent model...
- Combination chemo-siRNA gene therapy of nonmuscle-invading bladder cancerZe Lu; Fiscal Year: 2012..The second group, the muscle-invading tumors, is managed by partial or complete cystectomy (removal of bladder), which presents significant risks and is not well tolerated by older patients...
- Optical Imaging of Bladder Cancer with Molecular Contrast AgentsJoseph C Liao; Fiscal Year: 2013..e. radical cystectomy)...
- Urinary Diversion Among Bladder Cancer Survivors: Cost, Complications, and QOLCARMIT KURN MCMULLEN; Fiscal Year: 2013..Each year 7,000 people with bladder cancer in the United States have cystectomy surgery (bladder removal)...
- Investigation of a nanoparticle albumin-bound mTOR inhibitor, nab-rapamycin for tNeil Desai; Fiscal Year: 2013..have been explored in the second-line setting with only limited efficacy, forcing many patients into a radical cystectomy. Because of high disease recurrence and morbidity, the cost per bladder cancer patient is among the highest of ..
- Anti-Tumor Mechanisms and Therapeutic Effects of Vitamin DDonald L Trump; Fiscal Year: 2013..trial, the effect of calcitriol (phase I dose, D1, 2), cisplatin (75mg/m2, D2 every 28days) and gemcitabine (800mg/m2, D2 weekly) for 3 cycles before cystectomy in muscle-invading transitional cell bladder cancer.
- Evaluation of a novel urothelial cancer biomarker of lethalityJONATHAN ERIC ROSENBERG; Fiscal Year: 2013..g. early cystectomy for non-invasive UC). This work will provide the foundation for future studies to develop the 1q23...
- DT-EGF Toxic Fusion Protein for Treatment of Bladder CancerMike Glodé; Fiscal Year: 2012..resection and BCG administration is unsuccessful in about 40% of cases with recurrences that eventually require cystectomy or other aggressive therapy...
- Immunotherapeutic minicells for use in intermediate and high-risk non-muscle invaROGER ALLEN SABBADINI; Fiscal Year: 2013..or BCG-relapsed (together 45-50%) and for those patients that are BCG-intolerant (~20%) is immediate cystectomy and urinary diversion, which exacts a heavy toll in the form of acute and chronic morbidity, we feel major ..
- MCAV in Organ-Confined Bladder CA based on p53 StatusRichard Cote; Fiscal Year: 2006..associated with an increased chance of progression in patients with organ-confined TCC managed by radical cystectomy. Our hypothesis is that p53 alterations organ-confined TCC of the bladder significantly increase the risk of ..
- PHARMACODYNAMICS OF AGENTS FOR BLADDER CANCER THERAPYJESSIE AU; Fiscal Year: 2003..in vivo using bladders removed from dogs and from patients who receive drug instillation at the time of total cystectomy. This will indicate whether effective drug concentrations are achieved at the tumor sites. A.3...
- REGENERATION OF FUNCTIONAL SMOOTH MUSCLE TISSUEEmil Tanagho; Fiscal Year: 2004..matrix bladder when grafted to the host bladder (normal, diabetic and interstitial cystitis) after partial cystectomy. These growth factors will stimulate the process of ingrowth of smooth muscle, urothelial lining, ..
- A COMPARISON OF IN VIVO AND VITRO TISSUE ENGINEERINGBradley Kropp; Fiscal Year: 2004..Using the canine subtotal cystectomy model, animals will undergo urinary bladder augmentations utilizing unseeded PAP and SIS (in vivo technology) ..
- TREATMENT AND PREVENTION OF IMPOTENCETom Lue; Fiscal Year: 1990..2. Intraoperative neurostimulation in patients undergoing radical cystectomy or radical prostatectomy for cancer of the bladder and prostate. 3...
- PHARMACOLOGY OF NEW INTRAVESICAL THERAPEUTICSTrevor Sweatman; Fiscal Year: 1992..to human disease, urothelial drug penetration will be studied in a limited series of patients undergoing total cystectomy for advanced bladder carcinoma, with results compared to data obtained in animal studies...
- PHARMACODYNAMICS OF AGENTS FOR BLADDER CANCERJESSIE AU; Fiscal Year: 1991..of the bladder and the depth of drug penetration in vivo using bladders removed from patients who receive total cystectomy shortly after drug instillation. 3...
- P53 GENE THERAPY FOR LOCALLY ADVANCED BLADDER CANCERLance Pagliaro; Fiscal Year: 2000DESCRIPTION: (Applicant's Abstract) The standard treatment for muscle- invasive bladder cancer is cystectomy. Though often curative, this is a mutilating procedure and its effects on quality of life are unacceptable to many patients...
- BLADDER CANCER--SUPPESSOR GENES AND RADIATION RESPONSEChi Wei Lin; Fiscal Year: 1993..This has required clinicians to recommend cystectomy, with its associated major losses of genitourinary function, to patients with muscle-invading tumors even though ..
- BIOMARKERS FOR BLADDER CANCER CHEMOPREVENTION TRIALSWalter Stadler; Fiscal Year: 1999..b>Cystectomy is generally required for muscle invasive disease...
- Chemoprevention of murine urinary bladder carcinogenesisAshish Kamat; Fiscal Year: 2005..abstract_text> ..
- Validation of Medicare Claims to Define Chemotherapy UseDeborah Schrag; Fiscal Year: 2005..This knowledge has the potential to lay the groundwork for development of an inexpensive and efficient system for monitoring and improving the quality of US cancer care. ..
- hAR Alterations and Androgen-Independent Prostate CancerRalph de Vere White; Fiscal Year: 2007..unreadable] [unreadable]..
- COLUMBIA UNIVERSITY SOUTHWEST ONCOLOGY GROUP PROGRAMDaniel Petrylak; Fiscal Year: 2003..Based on substantial laboratory strength, we intend to integrate Columbia laboratory resources as core support for SWOG clinical studies. ..
- Neurotrophins and Tyrosine Kinases in Prostate CancerChristopher Evans; Fiscal Year: 2006..This proposal is based on significant preliminary data and has strong translational potential for future proposals. ..
- TUMT verses Medical Therapy in Treatment of BPHE Crawford; Fiscal Year: 2005..The PI has enlisted the support of consultants who will assist in this important evaluation. The results of this analysis will be critical in allocating health care resources. ..
- PARADIGM OF MULTISTEP URINARY BLADDER CARCINOGENESISBogdan Czerniak; Fiscal Year: 2006....
- Methodology of Phase I and II trials of anticancer CAMAndrew Vickers; Fiscal Year: 2004....
- FUNCTIONS OF DIFFERENT P53 MUTATIONS IN PROSTATE CANCERRalph deVere White; Fiscal Year: 2004..The results obtained during the period of this grant proposal will form the basis for future studies that should affect treatment strategies for this disease. ..
- Yeast Assay for p53 Molecular Analysis in Bladder CancerRalph deVere White; Fiscal Year: 2005..The archival-based yeast functional assay technology will be used in testing bladder cancer specimens (cystectomy and TURBT) and then comparing their p53 status to patient clinical outcomes...