Genomes and Genes
Summary: Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)
Publications301 found, 100 shown here
- Intracerebral hemorrhage: getting ready for effective treatmentsFred Rincon
Department of Medicine, Division of Neurology and Critical Care, Cooper University Hospital, University of Medicine and Dentistry of New Jersey, Camden, New Jersey, USA
Curr Opin Neurol 23:59-64. 2010..The purpose of this article is to review recent advances in the management of spontaneous intracerebral hemorrhage...
- Outcome of contemporary surgery for chronic subdural haematoma: evidence based reviewR Weigel
Department of Neurosurgery, University Hospital, Klinikum Mannheim, Mannheim, Germany
J Neurol Neurosurg Psychiatry 74:937-43. 2003..To evaluate the results of surgical treatment options for chronic subdural haematoma in contemporary neurosurgery according to evidence based criteria...
- Operative intracranial infection following craniotomyShervin R Dashti
Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
Neurosurg Focus 24:E10. 2008..They focused their review on those patients who required repeated surgery to treat the infection...
- Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patientsA M Korinek
Neuroanaesthesia Unit, Department of Anaesthesiology, Pitie Salpetriere Hospital, University of Paris VI, Paris, France
Br J Neurosurg 19:155-62. 2005..During period B, prophylaxis was given to every craniotomy. The effect of prophylaxis on craniotomy infections, independently of other risk factors, was studied by ..
- A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomyAshraf S Habib
Duke University Medical Center, Box 3094, Durham, NC 27710, USA
Anesth Analg 112:813-8. 2011Postoperative nausea and vomiting (PONV) occur commonly after craniotomy. In patients receiving prophylaxis with ondansetron and dexamethasone, vomiting occurred in 45% of patients at 48 hours...
- Defining the "edge of the envelope": patient selection in treating complex sellar-based neoplasms via transsphenoidal versus open craniotomyGabriel Zada
Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosurg 114:286-300. 2011....
- Image-guided craniotomy for cerebral metastases: techniques and outcomesTze Ching Tan
Department of Neurosurgery, Brigham and Women s Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02215, USA
Neurosurgery 53:82-9; discussion 89-90. 2003....
- The management of primary chronic subdural haematoma: a questionnaire survey of practice in the United Kingdom and the Republic of IrelandT Santarius
Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
Br J Neurosurg 22:529-34. 2008..The current literature provides Class II and III evidence and there is a need for randomized studies to address the role of external drainage, steroids and postoperative bed rest...
- Bedside twist drill craniostomy for chronic subdural hematoma: a comparative studyEric M Horn
Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Surg Neurol 65:150-3; discussion 153-4. 2006Although the bedside twist drill craniostomy is used to treat chronic subdural hematomas, the efficacy of this technique has not been compared with that of standard treatments (operative bur hole or craniotomy).
- Chronic subdural haematoma: surgical treatment and outcome in 1000 casesMiguel Gelabert-Gonzalez
Neurosurgical Service, Department of Surgery, Clinic Hospital of Santiago, University of Santiago de Compostela, La Choupana, 15706 Santiago de Compostela, Spain
Clin Neurol Neurosurg 107:223-9. 2005..1980-2002) of the records of 1000 patients harbouring 1097 chronic subdural haematoma treated with burr-hole craniotomy with closed-system drainage was carried out...
- A comparative study of the patients with bilateral or unilateral chronic subdural hematoma: precipitating factors and postoperative outcomesTai Hsin Tsai
Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
J Trauma 68:571-5. 2010..The purpose of this study was to compare the clinical presentations, precipitating factors, computed tomography (CT) scan findings, postoperative complications, and outcomes between patients with bilateral and unilateral CSDH...
- Electroacupoint stimulation for postoperative nausea and vomiting in patients undergoing supratentorial craniotomyXiao qiang Wang
Department of Neurosurgery, Huashan Hospital of Fudan University, Shanghai, China
J Neurosurg Anesthesiol 22:128-31. 2010We evaluated the effectiveness of transcutaneous electrical acupoint stimulation (TEAS) at the P6 acupoint for prevention of postoperative nausea and vomiting in patients undergoing supratentorial craniotomy.
- Wrong-site craniotomy: analysis of 35 cases and systems for preventionFred L Cohen
Gary Roberts and Associates, West Palm Beach, Florida, USA
J Neurosurg 113:461-73. 2010The purpose of this case review was to identify and analyze existing wrong-site craniotomy (WSC) cases to determine the factors that contributed to the errors and to suggest preventative strategies for WSC...
- Craniotomy for supratentorial brain tumors: risk factors for brain swelling after opening the dura materMads Rasmussen
Department of Neuroanesthesia, Arhus University Hospital, Arhus, Denmark
J Neurosurg 101:621-6. 2004Cerebral swelling often occurs during craniotomy for cerebral tumors...
- The effects of P6 electrical acustimulation on postoperative nausea and vomiting in patients after infratentorial craniotomyMing Xu
Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China
J Neurosurg Anesthesiol 24:312-6. 2012..We evaluated the effectiveness of transcutaneous electrical acupoint stimulation (TEAS) at P6 for the prophylaxis of PONV in patients undergoing infratentorial craniotomy.
- Postoperative nausea and vomiting in patients after craniotomy: incidence and risk factorsBjörn Latz
Klinik fur Anasthesiologie, Universitätsmedizin der Johannes Gutenberg Universität Mainz, Germany
J Neurosurg 114:491-6. 2011..of this study was to assess the incidence and risk factors of postoperative nausea and vomiting (PONV) after craniotomy because most available data about PONV in neurosurgical patients are retrospective in nature or derive from ..
- VEGF-releasing biodegradable nanospheres administered by craniotomy: a novel therapeutic approach in the APP/Ps1 mouse model of Alzheimer's diseaseEnara Herran
NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country UPV EHU, School of Pharmacy, Vitoria, Spain
J Control Release 170:111-9. 2013..out in amyloid precursor protein/presenilin-1 (APP/Ps1) mice administering VEGF-NS through minimally invasive craniotomy. The results obtained showed that VEGF-NS were able to improve behavioral deficits, decrease Aβ deposits and ..
- A comparison of two doses of mannitol on brain relaxation during supratentorial brain tumor craniotomy: a randomized trialCharlotte Quentin
Department of Anesthesiology, Montreal University Medical Centre, Montreal, Quebec, Canada
Anesth Analg 116:862-8. 2013..However, a dose-response relationship has not yet been established. In this study, we compared the effects of 0.7 and 1.4 g·kg(-1) mannitol on brain relaxation during elective supratentorial brain tumor surgery...
- Craniotomy for central nervous system metastases in epithelial ovarian carcinomaBhavana Pothuri
Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Gynecol Oncol 87:133-7. 2002..Numerous series have reported various modalities for treatment with median survivals of 3 to 5 months, but the role of craniotomy has not been specifically addressed.
- Dural augmentation: part I-evaluation of collagen matrix allografts for dural defect after craniotomyZachary N Litvack
Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
Neurosurgery 65:890-7; discussion 897. 2009..Our primary goal was to assess differences in the incidence of postoperative cerebrospinal fluid (CSF) leak, including fistula and pseudomeningocele, and postoperative infection between monolayer collagen and bilayer collagen grafts...
- Cranioplasty with individual carbon fibre reinforced polymere (CFRP) medical grade implants based on CAD/CAM techniqueW Saringer
Department of Neurosurgery, University of Vienna, Medical School, Vienna, Austria
Acta Neurochir (Wien) 144:1193-203. 2002..The authors present a new method for the reconstruction of large or complex-formed cranial bone defects using prefabricated, computer-generated, individual CFRP (carbon fibre reinforced plastics) medical grade implants...
- Management of supratentorial cavernous malformations: craniotomy versus gammaknife radiosurgeryYang Hsin Shih
Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 201, Sec 2, Shi Pai Road, Taipei 112, Taiwan
Clin Neurol Neurosurg 107:108-12. 2005Although craniotomy is the preferred treatment for symptomatic solitary supratentorial cavernous malformation (CM), radiosurgery is also an option...
- Microfibrillar collagen hemostat-induced necrotizing granulomatous inflammation developing after craniotomy: a pediatric case seriesLiat Apel-Sarid
Department of Pathology and Laboratory Medicine, Division of Anatomic Pathology, Children s and Women s Health Centre of British Columbia, University of British Columbia, Vancouver, British Columbia, Canada
J Neurosurg Pediatr 6:385-92. 2010..According to the literature, MCH induces a very characteristic mixed inflammatory response that is rich in eosinophils; in light of these observations, many authors have suggested an allergy-based pathogenesis...
- Craniotomy for resection of meningioma in the elderly: a multicentre, prospective analysis from the National Surgical Quality Improvement ProgramChirag G Patil
Outcomes Research Lab, Palo Alto Veterans Health Care System, Palo Alto, California, USA
J Neurol Neurosurg Psychiatry 81:502-5. 2010Whether there is an increased surgical risk in elderly patients who undergo craniotomy for meningioma resection remains a point of controversy...
- Neurological improvement after cranioplasty - analysis by transcranial doppler ultrasonographyJinn Rung Kuo
Department of Neurosurgery, Chi Mei Medical Center, Tainan, Taiwan
J Clin Neurosci 11:486-9. 2004..We conclude that cranioplasty can improve neurological status, and it should be performed as earlier as edema has resolved...
- A comparison between sevoflurane and desflurane anesthesia in patients undergoing craniotomy for supratentorial intracranial surgeryGiuseppina Magni
Department of Anesthesia and Intensive Care, La Sapienza University, Policlinico Umberto I Roma, Rome, Italy
Anesth Analg 109:567-71. 2009..In this prospective clinical trial, we compared early postoperative recovery and cognitive function in patients undergoing craniotomy for supratentorial expanding lesions and receiving sevoflurane or desflurane anesthesia.
- The efficacy of 5-HT3 receptor antagonists for the prevention of postoperative nausea and vomiting after craniotomy: a meta-analysisSusan M Neufeld
University of Alberta, Edmonton, Alberta, Canada
J Neurosurg Anesthesiol 19:10-7. 2007..After a systematic search, 7 published randomized placebo controlled trials involving 448 craniotomy patients (222 treatment, 226 control) were included in the meta-analysis...
- Neurosurgical craniotomy localization using a virtual reality planning system versus intraoperative image-guided navigationAxel T Stadie
Neurochirurgische Klinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Int J Comput Assist Radiol Surg 6:565-72. 2011Accurate craniotomy placement is essential for frameless neuronavigation in minimally invasive neurosurgery. A craniotomy using virtual reality (VR) can be as accurate as neuronavigation.
- Hyperglycemia in patients administered dexamethasone for craniotomyMichael B Lukins
Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
Anesth Analg 100:1129-33. 2005..study, we documented the blood glucose concentration changes for 12 h in 34 nondiabetic patients undergoing craniotomy and compared patients who received intraoperative dexamethasone (10 mg IV on induction and 4 mg IV 6 h later), ..
- Effect of clipping, craniotomy, or intravascular coiling on cerebral vasospasm and patient outcome after aneurysmal subarachnoid hemorrhageBrian L Hoh
Neurosurgical Service, Endovascular Neurosurgery and Interventional Neuroradiology, and Cerebrovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurgery 55:779-86; discussion 786-9. 2004..We reviewed our experience over 8 years and assessed whether clipping, craniotomy, or coiling affects patient outcomes or the risk for vasospasm.
- Use of hinge craniotomy for cerebral decompression. Technical noteJohn H Schmidt
Department of Surgery, School of Medicine, West Virginia University Health Sciences Center, Charleston Division, USA
J Neurosurg 107:678-82. 2007..The authors developed a novel craniotomy technique using titanium bone plates in a hinged fashion, which maintains cerebral protection while reducing ..
- Relationship between drainage catheter location and postoperative recurrence of chronic subdural hematoma after burr-hole irrigation and closed-system drainageH Nakaguchi
Department of Neurosurgery, Tokyo Kosei Nenkin Hospital, Tokyo, Japan
J Neurosurg 93:791-5. 2000..This study was conducted to determine the best position for the subdural drainage catheter to achieve a low recurrence rate after burr-hole irrigation and closed-system drainage of chronic subdural hematoma (CSDH)...
- Customised fabricated implants after previous failed cranioplastyRaymond C W Goh
Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5 Fu Shin Street, Kwei Shan, Taoyuan 333, Taiwan
J Plast Reconstr Aesthet Surg 63:1479-84. 2010..Customised fabricated alloplastic implants provide a safe, accurate and efficient way of restoring normal cranial contours in patients with cranial defects who have had previous failed cranioplasties...
- Taylored implants for alloplastic cranioplasty--clinical and surgical considerationsB Hoffmann
Neurosurgical Clinic, Clemenshospital Münster, Germany
Acta Neurochir Suppl 93:127-9. 2005..Application of this technique is limited by cost, nonetheless it is recommended for extensive reconstruction of the skull...
- Craniotomy for the resection of metastatic brain tumors in the U.S., 1988-2000: decreasing mortality and the effect of provider caseloadFred G Barker
Brain Tumor Center, Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 100:999-1007. 2004....
- Combined trans-sphenoidal and simultaneous trans-ventricular-endoscopic decompression of a giant pituitary adenoma: case reportBal Krishna Ojha
Department of Neurosurgery, CSM Earlier King George s Medical University, Lucknow 226003, India
Acta Neurochir (Wien) 151:843-7; discussion 847. 2009..This is the first report of the simultaneous combined use of trans-sphenoidal and trans-ventricular-endoscopic route for decompression of a giant pituitary adenoma...
- Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesiaKurt D Petersen
Department of Anesthesia and Neurosurgery, Aarhus University Hospital, Denmark
Anesthesiology 98:329-36. 2003A critical point during craniotomy is opening of dura, where a high intracranial pressure (ICP) results in swelling of cerebral tissue...
- Bone flap preservation after decompressive craniectomy--experience with 55 casesPrasad Krishnan
Department of Neurosurgery, National Neurosciences Centre, Kolkata, 700 031, India
Neurol India 54:291-2. 2006....
- Craniotomy for resection of pediatric brain tumors in the United States, 1988 to 2000: effects of provider caseloads and progressive centralization and specialization of careEdward R Smith
Massachusetts General Hospital, and Department of Surgery Neurosurgery, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurgery 54:553-63; discussion 563-5. 2004..We used a national hospital discharge database to study the volume-outcome relationship for craniotomy performed for pediatric brain tumor resection, as well as trends toward centralization and specialization.
- Inhalational or intravenous anesthetics for craniotomies? Pro inhalationalKristin Engelhard
Klinik fur Anasthesiologie, Johannes Gutenberg Universitat, Mainz, Germany
Curr Opin Anaesthesiol 19:504-8. 2006....
- Effect of prophylactic ondansetron on postoperative nausea and vomiting in patients on preoperative steroids undergoing craniotomy for supratentorial tumorsJyotsna Wig
Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India
J Neurosurg Anesthesiol 19:239-42. 2007..sex who had received preoperative steroids (dexamethasone) for at least 24 hours and were scheduled to undergo craniotomy for supratentorial tumors were included...
- Prevention and control of postoperative nausea and vomiting in post-craniotomy patientsL H J Eberhart
Department of Anaesthesiology and Intensive Care, Philipps University Marburg, Baldingerstrasse, D 35033 Marburg, Germany
Best Pract Res Clin Anaesthesiol 21:575-93. 2007..However, emetic symptoms can also cause major medical complications, and post-craniotomy patients may be at an increased risk...
- Preservation of bone flap after craniotomy infectionPedro David Delgado-López
Servicio de Neurocirugia, Hospital General Yague, Burgos
Neurocirugia (Astur) 20:124-31. 2009The estimated incidence of craniotomy infection is 5%, ranging from 1-11% depending on the presence of certain risk factors, such as, prior radiation therapy, repeated surgery, CSF leak, duration of surgery over 4h, interventions ..
- Standard large trauma craniotomy for severe traumatic brain injuryLi quan Lü
Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Chin J Traumatol 6:302-4. 2003To study the effect of standard large trauma craniotomy (SLTC) on outcomes of patients with severe traumatic brain injury (TBI) (GCS<=8).
- Early recovery and better evacuation rate in neuroendoscopic surgery for spontaneous intracerebral hemorrhage using a multifunctional cannula: preliminary study in comparison with craniotomyToru Nagasaka
Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65Tsurumai Cho, Nagoya, Aichi, Japan
J Stroke Cerebrovasc Dis 20:208-13. 2011..We sought to compare the clinical outcomes between neuroendoscopic surgery and craniotomy for spontaneous ICH...
- Age and salvageability: analysis of outcome of patients older than 65 years undergoing craniotomy for acute traumatic subdural hematomaPhilipp Taussky
Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
World Neurosurg 78:306-11. 2012..Yet, the operative treatment of patients older than 65 years of age for aSDH remains controversial, and very limited data exists with regard to expected outcome in this elderly patient group...
- Bilateral orbital infarction syndrome after bifrontal craniotomyPhilip Maier
University Eye Hospital Freiburg, Killianstr 5, 79106 Freiburg, Germany
Arch Ophthalmol 125:422-3. 2007
- Day surgery awake craniotomy for removing brain tumours: technical note describing a simple protocolG Carrabba
Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada
Minim Invasive Neurosurg 51:208-10. 2008Day surgery awake craniotomy has been recently proposed for patients harbouring supratentorial brain tumours...
- Outpatient craniotomy for brain tumor: a pilot feasibility study in 46 patientsM Bernstein
Division of Neurosurgery, Toronto Western Hospital, University Health Network, ON, Canada
Can J Neurol Sci 28:120-4. 2001BACKGROUND: Since 1991 the author has routinely performed awake craniotomy for intra-axial brain tumors with low complication rate and low resource utilization...
- Application accuracy of computed tomography-based, image-guided navigation of temporal bonePromod Pillai
Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
Neurosurgery 63:326-32; discussion 332-3. 2008..We investigated the application accuracy of computed tomography-based, frameless, image-guided navigation to identify various bony structures in the temporal bone via a retrosigmoid approach...
- The effects of 10 degrees reverse trendelenburg position on ICP and CPP in prone positioned patients subjected to craniotomy for occipital or cerebellar tumoursA Tankisi
Department of Neuroanaesthesia, Aarhus Kommunehospital, Aarhus University Hospital, Denmark
Acta Neurochir (Wien) 144:665-70. 2002Control of ICP-hypertension is of utmost importance during craniotomy. The effects of reverse Trendelenburg position (RTP) upon ICP and CPP have recently been studied in supine positioned patients.
- Is it time to replace the Wada test and put awake craniotomy to sleep?Andrew C Papanicolaou
Department of Pediatrics, Division of Clinical Neurosciences, University of Tennessee Health Science Center, Memphis, Tennessee, U S A Neuroscience Institute, Le Bonheur Children s Hospital, Memphis, Tennessee, U S A
Epilepsia 55:629-32. 2014....
- Cerebellar hemorrhage after supratentorial craniotomyGerhard Marquardt
Neurosurgical Clinic, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
Surg Neurol 57:241-51; discussion 251-2. 2002Cerebellar hemorrhage following supratentorial craniotomy is a very seldom described but serious complication...
- Awake craniotomy for microsurgical obliteration of mycotic aneurysms: technical report of three casesJürgen C Lüders
Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Neurosurgery 56:E201; discussion E201. 2005..Three cases of awake craniotomy for microsurgical clipping of mycotic aneurysms are presented...
- [Clinical observation of granisetron in preventing postoperative nausea and vomiting following supratentorial craniotomy]Yun jiao Wang
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China
Hunan Yi Ke Da Xue Xue Bao 27:545-6. 2002To observe the prophylactic effect of granisetron on postoperative nausea and vomiting (PONV) after supratentorial craniotomy.
- Venous air embolism during awake craniotomy in a supine patientMrinalini Balki
Department of Anesthesia, The Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Can J Anaesth 50:835-8. 2003To report a non-fatal case of intraoperative venous air embolism (VAE) during an awake craniotomy. VAE presented with unusual clinical features.
- Is postoperative intensive care unit admission a prerequisite for elective craniotomy?John Q H Bui
Department of Neurosurgery, Liverpool Hospital, University of New South Wales, Sydney, New South Wales, Australia
J Neurosurg 115:1236-41. 2011..to the intensive care unit (ICU) is often considered a necessity in the treatment of patients following elective craniotomy but may strain already limited resources and is of unproven benefit...
- Outcome of fully awake craniotomy for lesions near the eloquent cortex: analysis of a prospective surgical series of 79 supratentorial primary brain tumors with long follow-upLuiz Claudio Modesto Pereira
Hospital de Base do Distrito Federal, Brasilia, Brazil
Acta Neurochir (Wien) 151:1215-30. 2009Despite possible advantages, few surgical series report specifically on awake craniotomy for intrinsic brain tumors in eloquent brain areas.
- Surgical site infections following craniotomy focusing on possible post-operative acquisition of infection: prospective cohort studyO Sneh-Arbib
Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
Eur J Clin Microbiol Infect Dis 32:1511-6. 2013..Included were adult patients undergoing clean or clean-contaminated craniotomy, including craniotomies with external CSF drainage or shunts...
- Awake craniotomy and electrophysiological mapping for eloquent area tumoursAri George Chacko
Department of Neurological Sciences, Section of Neurosurgery, Christian Medical College, Vellore, Tamil Nadu, India
Clin Neurol Neurosurg 115:329-34. 2013An awake craniotomy facilitates radical excision of eloquent area gliomas and ensures neural integrity during the excision. The study describes our experience with 67 consecutive awake craniotomies for the excision of such tumours.
- 'Scheduled' dosing of lornoxicam provides analgesia superior to that provided by 'on request' dosing following craniotomyElena V Dolmatova
Faculty of Basic Medicine, Moscow State University, Moscow, Russia
Eur J Anaesthesiol 26:633-7. 2009The aim of this study was to compare the efficacy of 'scheduled' analgesia with analgesia 'on request in patients after craniotomy.
- The keyhole concept in aneurysm surgery--a comparative study: keyhole versus standard craniotomyJ Paladino
Department of Neurosurgery, School of Medicine, University of Zagreb, Croatia
Minim Invasive Neurosurg 48:251-8. 2005The purpose of the study is to compare the results of minimally invasive keyhole craniotomy and standard larger craniotomies in the surgical treatment of patients with intracranial aneurysms.
- Salvage of infected craniotomy bone flaps with the wash-in, wash-out indwelling antibiotic irrigation system. Technical note and case series of 12 patientsKurtis I Auguste
Department of Neurological Surgery, University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
J Neurosurg 105:640-4. 2006When complicated by infection, craniotomy bone flaps are commonly removed, discarded, and delayed cranioplasty is performed...
- Sudden visual loss due to posterior ischemic optic neuropathy following craniotomy for a ruptured intracranial aneurysmKishor A Choudhari
Department of Neurosurgery, Royal Victoria Hospital, Regional Neurosciences Unit, Belfast BT12 6BA, United Kingdom
Neurol India 55:163-5. 2007The authors report a rare case of acute ipsilateral blindness that occurred after a standard fronto-temporal craniotomy for aneurysm in supine position...
- Dexmedetomidine attenuates the hemodynamic and neuroendocrinal responses to skull-pin head-holder application during craniotomyAhmet Senol Uyar
Clinic of Anesthesiology and Reanimation, The Ministry of Health Ankara Research and Training Hospital, Ankara, Turkey
J Neurosurg Anesthesiol 20:174-9. 2008..heart rate, arterial blood pressure, and neuroendocrinal responses to skull-pin head-holder application during craniotomy. In a randomized, double-blinded, placebo-controlled study, 40 patients undergoing craniotomy with attachment of ..
- Effect of head positioning on outcome after burr hole craniostomy for chronic subdural haematomaAsim Ishfaq
Department of Neurosurgery, Combined Military Hospital, Rawalpindi
J Coll Physicians Surg Pak 19:492-5. 2009..To determine the effect of position of the patient's head after burr hole craniostomy on the outcome of chronic subdural haematoma, in terms of haematoma efflux, hospital stay and recurrence rate...
- Effect of single-dose dexamethasone on blood glucose concentration in patients undergoing craniotomyJeffrey J Pasternak
Department of Anesthesiology, Mayo Clinic and College of Medicine, Rochester, Minnesota 55905, USA
J Neurosurg Anesthesiol 16:122-5. 2004..bolus of dexamethasone or a saline placebo were evaluated in nondiabetic patients undergoing elective craniotomy. Both arterial and venous blood glucose concentrations were obtained immediately before and after treatment and ..
- A randomized trial of very early decompressive craniectomy in children with traumatic brain injury and sustained intracranial hypertensionA Taylor
Intensive Care Department, Royal Children's Hospital, Melbourne, Victoria, Australia
Childs Nerv Syst 17:154-62. 2001..046; owing to multiple significance testing P <0.0221 is required for statistical significance). This pilot study suggests that very early decompressive craniectomy may be indicated in the treatment of traumatic brain injury...
- Extended pericranial flap and bone graft reconstruction in anterior skull base surgeryMichael Rodrigues
University of Maryland School of Medicine, University of Maryland Hospital, Baltimore, MD, USA
Otolaryngol Head Neck Surg 131:69-76. 2004..Study design Thirty-four patients underwent anterior craniofacial resection of anterior skull-based tumors of varying histology with reconstruction using an extended pericranial flap and split calvarial bone graft...
- Harvesting blood stem cells from cranial bone at craniotomy--a preliminary studyTomomi Iwashita
Department of Neurosurgery, Aizawa Hospital, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
J Neurooncol 64:265-70. 2003..In this study, we examined whether blood stem cells can be harvested from cranial bone at craniotomy. Bone marrow cells in cranial bone were counted in 181 craniotomy specimens after staining with hematoxylin and ..
- Routine use of postoperative ICU care for elective craniotomy: a cost-benefit analysisCurtis L Beauregard
Department of Neurological Surgery, University of Florida, Gainesville, Florida 32610, USA
Surg Neurol 60:483-9; dicussion 489. 2003Postoperative monitoring in an intensive care unit (ICU) setting following elective craniotomy is routine at many institutions, as it is believed that this reduces the incidence and potential seriousness of early postoperative ..
- Hemodynamic effects of decompressive craniotomy in MCA infarction: evaluation with perfusion CTMartin Bendszus
Department of Neuroradiolgoy, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
Eur Radiol 13:1895-8. 2003Decompressive craniotomy in hemispheric infarction has been reported to reduce mortality and improve outcome. Identifying tissue at risk and monitoring the benefit of craniotomy is hardly practical and has not been reported thus far...
- Clinical evaluation of the polypropylene-polyester knit used as a cranioplasty materialS Andrzejak
Department of Neurosurgery, Medical University of Lodz, Lodz, Poland
Acta Neurochir (Wien) 147:973-6; discussion 976. 2005..The paper presents clinical evaluation of the polypropylene-polyester knit used as a cranioplasty material...
- Dysfunction of the temporalis muscle after pterional craniotomy for intracranial aneurysms. Comparative, prospective and randomized study of one flap versus two flaps dieresisF C de Andrade Júnior
Department of Neurological Surgery and Bucomaxillofacial Surgery Service, Pontifical Catholic University of São Paulo Medical Sciences School, Sorocaba, SP, Brazil
Arq Neuropsiquiatr 56:200-5. 1998Patients with intracranial aneurysm(s) of the carotid artery territory, treated with pterional craniotomy, were prospectively and randomly addressed to one layer flap (n = 36) or myocutaneous (MC) versus two layers' dieresis (n = 32) or ..
- Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhageL B Morgenstern
Stroke Program, Department of Neurology, University of Texas Houston Medical School, 77030, USA
Neurology 56:1294-9. 2001..A modest benefit was previously demonstrated for hematoma evacuation within 12 hours of intracerebral hemorrhage onset. Perhaps surgery within 4 hours would further improve outcome...
- Postoperative epilepsy in patients undergoing craniotomy for glioblastoma multiformeA E Telfeian
Dept of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
J Exp Clin Cancer Res 20:5-10. 2001..The primary goal of this study was to determine who, of those undergoing craniotomy for GBM resection, is at risk for epilepsy...
- Remifentanil-propofol vs dexmedetomidine-propofol--anesthesia for supratentorial craniotomyNamigar Turgut
Department of Anaesthesiology and Reanimation, S B Okmeydani Teaching and Research Hospital, Istanbul, Turkey
Middle East J Anaesthesiol 20:63-70. 2009..In a prospective randomized double-blind study 50 ASAI-III patients scheduled for supratentorial craniotomy, were allocated into two equal Groups. Group D patients (n = 25), received i.v...
- [Clinical observation on effect of huoxue jieyu decoction in treating depression after craniotomy: a report of 45 cases]Ning quan Zhou
Department of Brain Surgery, Qiannan Prefacture People s Hospital, Guizhou
Zhongguo Zhong Xi Yi Jie He Za Zhi 25:1020-2. 2005To observe the therapeutic effect of Huoxue Jieyu decoction (HJD) on patients with depression after craniotomy.
- Awake craniotomy under local anaesthesia and monitored conscious sedation for resection of brain tumours in eloquent cortex--outcomes in 20 patientsDavid Low
Department of Neurosurgery, National Neuroscience Institute, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
Ann Acad Med Singapore 36:326-31. 2007..We review the safety and effectiveness of craniotomy under local anaesthesia and monitored conscious sedation for resection of mass lesions involving eloquent cortex.
- Surface landmarks for the junction between the transverse and sigmoid sinuses: application of the "strategic" burr hole for suboccipital craniotomyR Shane Tubbs
Section of Pediatric Neurosurgery, Children s Hospital, Birmingham, Alabama, USA
Neurosurgery 65:37-41; discussion 41. 2009..We have studied external skull bony landmarks to facilitate the placement of the initial "strategic" burr hole just inferior and medial to the junction of transverse-sigmoid venous sinuses during standard retrosigmoid craniotomy.
- Combined transsphenoidal and pterional craniotomy approach to giant pituitary tumorsCargill H Alleyne
Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Surg Neurol 57:380-90; discussion 390. 2002..We describe a combined simultaneous approach to giant pituitary tumors and present a review of 10 patients undergoing this procedure with emphasis on patient selection, surgical technique, and results...
- Low-profile 1-piece bifrontal craniotomy for anterior skull base approach and reconstructionFatma Ozlen
Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
J Craniofac Surg 21:233-8. 2010..These pathologic lesions are treated by bifrontal craniotomy and anterior skull base approach, either primarily or combined with facial osteotomies...
- Comparison of the analgesic efficacy and respiratory effects of morphine, tramadol and codeine after craniotomyP S Sudheer
University of Wales College of Medicine, Heath Park, Cardiff, UK
Anaesthesia 62:555-60. 2007Pain after craniotomy remains a significant problem. The effect of morphine and tramadol patient-controlled analgesia (PCA) on arterial carbon dioxide tension is unknown in patients having such surgery...
- Craniotomy procedures are associated with less analgesic requirements than other surgical proceduresP J Dunbar
Department of Anesthesiology, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104 2499, USA
Anesth Analg 88:335-40. 1999..Our results confirm that the average craniotomy patient has less postoperative pain than patients who undergo other surgical procedures, although patients who ..
- Post-craniotomy analgesia: current practices in British neurosurgical centres--a survey of post-craniotomy analgesic practicesG C Roberts
University Hospital of Wales, B4 Neurosurgery, Cardiff, Wales, UK
Eur J Anaesthesiol 22:328-32. 2005An evaluation of post-craniotomy analgesia within the University Hospital of Wales Neurosurgical Unit, Cardiff, found that many patients were experiencing moderate to severe pain post-craniotomy...
- Craniotomy for treatment of unruptured aneurysms is not associated with long-term cognitive dysfunctionElizabeth Tuffiash
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 34:2195-9. 2003..The goal of this study was to identify changes in cognitive function associated with surgical clipping of unruptured intracerebral aneurysms...
- [Craniotomy side for neck clipping of the anterior communicating aneurysm via the pterional approach]Shinichiro Okamoto
Department of Neurosurgery, Osaka Red Cross Hospital, 5 53 Fudegasaki cho, Tennoji ku, Oasaka city, Osaka 543 8555, Japan
No Shinkei Geka 30:285-91. 2002..of the anterior communicating artery (Acom) aneurysm via the pterional approach was evaluated in terms of craniotomy side in 39 consecutive cases operated on by the senior surgeon from April 1991 through March 2000...
- Does hyperventilation improve operating condition during supratentorial craniotomy? A multicenter randomized crossover trialAdrian W Gelb
Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Ave, C 450, San Francisco, CA 94143 0648, USA
Anesth Analg 106:585-94, table of contents. 2008..crossover, randomized trial to evaluate surgeon-assessed brain bulk and measured intracranial pressure (ICP) in patients undergoing craniotomy for removal of supratentorial brain tumors during moderate hypocapnia or normocapnia.
- Passive real-time identification of speech and motor cortex during an awake craniotomyJarod Roland
Department of Neurological Surgery, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
Epilepsy Behav 18:123-8. 2010..reduce the amount of necessary stimulation, we used a passive mapping procedure in the setting of an awake craniotomy for tumor in two patients resection...
- The use of recombinant activated factor VIIa in coagulopathic traumatic brain injuries requiring emergent craniotomy: is it beneficial?Nathaniel McQuay
Department of Surgery, University of Pennsylvania Health System, Trauma Critica Division, St Luke s Hosptial, USA
J Neurosurg 111:666-71. 2009..This study evaluates the outcomes of using rFVIIa as first-line therapy in patients with a severe TBI requiring emergent craniotomy that are coagulopathic.
- Awake craniotomy for aggressive resection of primary gliomas located in eloquent brainF B Meyer
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 76:677-87. 2001....
- Dural arteriovenous fistula after craniotomy for pilocytic astrocytoma in a patient with protein S deficiencyReza Yassari
Section of Neurosurgery, Department of Surgery and Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Surg Neurol 58:59-64; discussion 64. 2002..We report an unusual case, which may provide insight into the etiology and pathogenesis of dural arteriovenous malformation...
- The use of continuous positive airway pressure during an awake craniotomy in a patient with obstructive sleep apneaTessa Huncke
Department of Anesthesiology, New York University Medical Center, Rusk Institute, New York, NY 10016, USA
J Clin Anesth 20:297-9. 2008..We describe the anesthetic management of a morbidly obese patient with obstructive sleep apnea who underwent awake craniotomy. The patient's personal continuous positive airway pressure (CPAP) machine was used to support ventilation ..
- Role of craniotomy in the management of pituitary adenomas and sellar/parasellar tumorsWael Musleh
The University of Chicago, Division of Neurosurgery, Chicago, IL 60637, USA
Expert Rev Anticancer Ther 6:S79-83. 2006..Overall, craniotomies will continue to play a role in the management of patients with sellar/parasellar tumors, although patient selection and careful preoperative evaluation are key elements in choosing the most appropriate approach...
- Decompressive craniotomy: durotomy instead of duroplasty to reduce prolonged ICP elevationRalf Burger
Department of Neurosurgery, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
Acta Neurochir Suppl 102:93-7. 2008..Several longitudinal durotomies avoid these limitations, but it remains a matter of discussion if durotomies reduce ICP sufficiently...
- Application of a hydrogel sealant improves watertight closures of duraplasty onlay grafts in a canine craniotomy modelMark C Preul
Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
J Neurosurg 107:642-50. 2007..The authors evaluated whether a polyethylene glycol-based hydrogel sealant system improved dural closures with collagen-based duraplasty onlay grafts...
- Difficult airway management following supratentorial craniotomy: a useful maneuver with a new deviceIrene P Osborn
Anesth Analg 105:552-3. 2007
- Orbitozygomatic craniotomy. Technical noteJ M Zabramski
Division of Neurological Surgery, Barrow Neurological Institute, Mercy Healthcare Arizona, Phoenix, USA
J Neurosurg 89:336-41. 1998..At a follow-up evaluation after a period averaging 14 months, all patients were pleased with the cosmetic results of this approach...
- Early postoperative cognitive recovery after remifentanil-propofol or sufentanil-propofol anaesthesia for supratentorial craniotomy: a randomized trialF Bilotta
Department of Anesthesiology, Intensive Care and Pain Medicine, University of Rome La Sapienza, Viale Somalia 81, 00199 Rome, Italy
Eur J Anaesthesiol 24:122-7. 2007This study was designed to evaluate early postoperative cognitive recovery after total intravenous anaesthesia with remifentanil-propofol or sufentanil-propofol in patients undergoing craniotomy for supratentorial expanding lesions.
- Craniotomy for meningioma in the United States between 1988 and 2000: decreasing rate of mortality and the effect of provider caseloadWilliam T Curry
Brain Tumor Center, Neurosurgical Service, Massachusetts General Hospital, Boston 02114, USA
J Neurosurg 102:977-86. 2005..The goal of this study was to determine the risk of adverse outcomes after contemporary surgical treatment of meningiomas in the US and trends in patient outcomes and patterns of care...
- Recombinant factor VIIa for the correction of coagulopathy before emergent craniotomy in blunt trauma patientsCarlos V R Brown
Department of Surgery, University of Texas Southwestern Medical School Austin, University Medical Center Brackenridge Trauma Services, Austin, Texas 78701, USA
J Trauma 68:348-52. 2010..We hypothesize that rFVIIa would provide an effective and cost efficient means of correcting coagulopathy in patients with traumatic brain injury undergoing emergent craniotomy.
- HYPOTHERMIA DURING INTRACRANIAL ANEURYSM SURGERYMichael Todd; Fiscal Year: 2003..of surgery performed to obliterate the source of bleeding; as many as 25 percent of patients who undergo craniotomy for aneurysm clipping will have a new neurologic deficit when examined 12-24hrs postoperatively...
- MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMANancy Temkin; Fiscal Year: 2004..Patients with moderate or severe head injury (post-resuscitation Glasgow Coma Scale 3-12 or having an early craniotomy) are randomized to receive moderate doses of magnesium sulfate or placebo...
- Decompressive craniotomy versus medical therapy for refractory intracranial hyperRaminder Nirula; Fiscal Year: 2010..Decompressive craniotomy (DC) has been employed for refractory intracranial hypertension (ICH) for more than 50 years and has regained ..
- Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and HapticsP Pat Banerjee; Fiscal Year: 2010..This means that today, only 15% of cerebral aneurysms are treated by open craniotomy and aneurysm clipping as pioneered by M. G. Yasargil...
- Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and HapticsP Pat Banerjee; Fiscal Year: 2013DESCRIPTION (provided by applicant): IMMERSIVETOUCH(R) VIRTUAL REALITY-HAPTIC NEUROSURGERY SIMULATOR: CRANIOTOMY AND ANEURYSM CLIPPING Founded by principal investigator Dr. Pat Banerjee, ImmersiveTouch,(R) Inc...
- JAMES D KLEIN; Fiscal Year: 2014..Wireless electrodes will allow complete closure of the craniotomy used for surgical placement and will avoid the use of the transcranial multiwire cables that connect the ..
- Auditory Thalamic ImplantSTEVEN WAN CHEUNG; Fiscal Year: 2012..is implantation of intracranial devices to auditory structures accessible via infratentorial posterior fossa craniotomy under general anesthesia...
- Implementation and Effectiveness of a S. aureus Surgical Site Infection PreventioLoreen A Herwaldt; Fiscal Year: 2013..aureus SSIs among patients undergoing CO, THA, TKA, spine operations (SO), or craniotomy/craniectomy (CRANI);2) Identify facilitators and barriers to bundle implementation at the hospital, surgical ..
- Capacity Building for Decompressive Craniotomy in ColombiaJuan Carlos Puyana; Fiscal Year: 2013..We will compare outcomes for sTBI patients treated before and after the introduction of the algorithm, which will provide preliminary data to support an RCT about DC in clinical settings without ICP monitors. ..
- Kris Moe; Fiscal Year: 2014..in many instances, which has dramatically reduced the morbidity of gaining surgical access compared to an open craniotomy approach...
- Traumatic Brain Injury Clinical Trials NetworkHoward M Eisenberg; Fiscal Year: 2010..The proposed study of decompression craniotomy could be initiated in a relatively short time once the funding period begins...
- ROBERT JAMES WEBSTER; Fiscal Year: 2016..traditional approaches are highly invasive - they require either deconstruction of facial tissue and bone, or a craniotomy and associated trauma to the brain;and (3) there exists an underutilized, yet clinically proven alternative - ..
- EARLY HEMICRANIECTOMY TO MANAGE TRAUMATIC BRAIN INJURYWilliam Coplin; Fiscal Year: 1999..Group I will receive standardized hemicraniectomy; Group II will undergo traditional craniotomy with or without brain amputation, at the discretion of the attending neurosurgeon...
- JULIE GEORGIA PILITSIS; Fiscal Year: 2016..A subset of patients are candidates for open surgery and/or SRS. Open surgery via craniotomy in appropriate patients allows for tissue diagnosis, rapid relief of symptoms, and local disease control...
- Wireless Multichannel Electrocorticogram Recording for Epilepsy MonitoringStuart Cogan; Fiscal Year: 2009..The wireless subdural arrays will allow complete closure of the craniotomy used for surgical placement and will avoid the use of the transcranial multiwire cables that connect the ..
- Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth FactorArun Gosain; Fiscal Year: 2007..We will harvest tissue from both a fused suture and a patent suture from children undergoing craniotomy as part of the standard treatment for craniosynotosis...
- Revitalizing Allografts for Craniofacial ReconstructionEdward Schwarz; Fiscal Year: 2007..In addition, 30% of all major neurosurgical procedures involve craniotomy: 5% are the result of head trauma and 25% are not related to trauma...
- RAPID ESTIMATION OF HUMAN BRAIN TUMOR GROWTH KINETICSRichard Davis; Fiscal Year: 1993..of study, the BUdR labeling index (Ll) obtained from tumors that were exposed to a pulse of BUdR at the time of craniotomy have revealed that: 1) S phase fraction (or BUdR Ll) of individual brain tumors measured by BUdR labeling ..
- Patient and Health Care System Outcomes Following EEAPaula R Sherwood; Fiscal Year: 2013..following EEA and to compare outcomes between persons undergoing EEA and those who have undergone standard craniotomy matched on key variables...
- Cognitive Function After Intracranial Aneurysm SurgerySatwant Samra; Fiscal Year: 2005..partially blinded clinical study of the rate of recovery of cognitive function in patients who have undergone craniotomy for clipping of intracranial aneurysms...
- QUALITY OF LIFE--PARKINSON PATIENTS WITH NEURAL IMPLANTSCynthia McRae; Fiscal Year: 1999..Treatments include: 1) embryonic tissue implant and 2) sham surgery consisting of craniotomy alone. In the double-blind study, quality of life is assessed by a single global rating item...
- MAGNETIC RESONANCE SPECTROSCOPY--CLINICAL IMMUNOTHERAPYBrian Ross; Fiscal Year: 1991..De-bulking of the tumor during craniotomy. 4) Implantation of fully activated lymphocytes, together with IL-2, into the tumor bed...
- FUNCATIONAL ORGANIZATION OF HUMAN PRIMARY MOTOR CORTEXNancy Sicotte; Fiscal Year: 2001..intrinsic signaling (0IS) and direct cortical stimulation (DCS) in a group of tumor patients undergoing awake craniotomy. The results of this work will lead to a better understanding of the, physiology of the human motor system as ..
- MODELING OF BRAIN DEFORMATION DURING SURGERYKeith Paulsen; Fiscal Year: 2002..of these components has been demonstrated in a series of clinical cases analyzed retrospectively involving post-craniotomy brain sag which has been found to be one of the predominant modes of intraoperative brain deformation...
- NEURONAL CORRELATES OF HUMAN MEMORYGeorge Ojemann; Fiscal Year: 2001..Investigator's Abstract): Neural mechanisms of human memory are investigated utilizing a unique opportunity, craniotomy where the patient is awake under local anesthesia for a portion of the operation...
- CELLULAR MECHANISMS OF CRANIAL NONUNION FORMATIONJohn Schmitz; Fiscal Year: 1993..A craniofacial nonunion model will be developed in rats using 8 mm craniotomy defects...
- Estrogen and the Aging Blood Brain BarrierOAK CHI; Fiscal Year: 2002..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
- NABTC Member Intitution Grant (UCSF Project Leader)Susan Chang; Fiscal Year: 2008..The overall goal of this program is to more effectively treat patients with primary brain tumors, especially malignant glioma, with the purpose of increasing the duration and quality of survival. ..
- Novel MRI Contrast Agent for Monitoring Thermal AblationNathan Mcdannold; Fiscal Year: 2006..unreadable] [unreadable]..
- INVESTIGATION OF DOSE/EFFICACY PROPERTIES OF INTRAVENTR*Daniel Hanley; Fiscal Year: 2008..Abstract Not Provided ..
- Discovery of novel fluorescent reporter genesMing Zhao; Fiscal Year: 2004..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
- EGFR activity in T cell-influenced glioma invasiveness & chemosensitivityChristopher Wheeler; Fiscal Year: 2007..unreadable] [unreadable]..
- VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICINJohn Carey; Fiscal Year: 2005..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
- In Vivo Imaging of Post-Traumatic Cerebral Amyloid DepositionMarvin Bergsneider; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Intracerebral Infusion of Radiolabeled Specific AntibodyJohn Sampson; Fiscal Year: 2006..abstract_text> ..
- Dendritic Cell Immunotherapy of Malignant GliomasJohn Sampson; Fiscal Year: 2006..abstract_text> ..
- Evalution of Vestibular Function in Meniere's DiseaseJohn Carey; Fiscal Year: 2009..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..
- MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AWJohn Sampson; Fiscal Year: 2004....
- Trauma Center Brief Alcohol Treatments and Cost EffectivenesThomas J Esposito; Fiscal Year: 2010..New knowledge of the effectiveness, benefits and costs of these two Bl approaches would allow surgeons and trauma centers to make informed choices about alcohol interventions in trauma settings. ..
- ECM in Structure & Function of the Craniofacial ComplexPaul Krebsbach; Fiscal Year: 2005..The program will focus on the following areas: The Role of the Extracellular Matrix in: A) Suture formation B) Bone C) Teeth: Enamel D) Dentin and Cementum E) Temporomandibular Joint. ..
- A HEMODYNAMIC MODEL OF INTRACRANIAL PRESSURE DYNAMICSMarvin Bergsneider; Fiscal Year: 2002..An improved understanding of these disorders will offer new and better treatment modalities for millions of affected patients. ..
- Optimization of TMS for DepressionMark George; Fiscal Year: 2009..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] ..
- Antisense imaging of brain gene expression in vivoWilliam Pardridge; Fiscal Year: 2005..This technology could be extended to humans and to other organs. At present, there is no parallel technology that enables the non-invasive in vivo imaging of "any gene in any person," which is the goal of this work. ..
- Effects of Amino Acid Therapy on Hot Flashes in Postmenopausal WomenThomas Guttuso; Fiscal Year: 2007..The applicant will also attend two didactic training seminars in complementary & alternative medicine at The Osher Institute at Harvard Medical School and at the Duke Center for Integrative Medicine. ..
- GENE REGULATION AND FUNCTION OF AMELOBLASTINPaul Krebsbach; Fiscal Year: 2003....
- Cortical Basis of Perceptual GroupingCHARLES GRAY; Fiscal Year: 2005..Together, these experiments will enable us to investigate the neuronal correlate of contour integration in striate cortex, and advance our understanding of scene segmentation processes in general. ..
- Polysomal RNA Antitumor ImmunityJohn Chi; Fiscal Year: 2005..Results from these experiments will help characterize the potential use of dendritic cells transfected with polysomal RNA in creating antigen specific tumor vaccines for brain tumors. ..
- Corticocortical interactions in visual working memoryCHARLES GRAY; Fiscal Year: 2005..New analytical methods will be incorporated to evaluate and interpret the resulting data. And, completion of this initial phase of the research plan will form the basis for future applications. ..
- NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIAShailendra Joshi; Fiscal Year: 2005..abstract_text> ..
- Minimally Invasive Approaches for Craniofacial SurgeryMaria Troulis; Fiscal Year: 2005..abstract_text> ..
- Neurotrophin Blood/Brain Barrier Delivery in IschemiaWilliam Pardridge; Fiscal Year: 2006..unreadable] [unreadable]..
- BONE MARROW STROMAL CELLS FOR SKELETAL REGENERATIONPaul Krebsbach; Fiscal Year: 2005..The information gained from this study will provide an essential prerequisite for the development of regenerative approaches that utilize bone marrow stromal cells for gene-and cell-based therapies. ..
- Optimization of TMS for Depression - Coordinating CenterMark George; Fiscal Year: 2009..This coordinating Center Grant (CCG) application is submitted under a CSMD mechanism, linked to 4 clinical site grants (CSG). ..
- Genetic Analysis of Age Related Hearing ImpairmentRick A Friedman; Fiscal Year: 2010..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
- MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONSMark George; Fiscal Year: 2002..Thus, we plan to use interleaved fMRI and DBS to directly examine the effects of DBS on hypothesized brain circuits and to correlate this with immediate and longer-term (4 week) behavioral outcomes (mood and cognition). ..
- GENE REGULATION AND FUNCTION OF AMELOBLASTINPaul Krebsbach; Fiscal Year: 2002....
- Inhibitors of 5alpha-reductase for acne therapyLingna Li; Fiscal Year: 2002..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
- Study of a genetic network involved in ear developmentRick Friedman; Fiscal Year: 2005..These and future experiments represent the natural progression from my Mentored Clinical Scientist Development Award (K08). ..
- NEURONAL PROCESSING OF NATURAL IMAGESCHARLES GRAY; Fiscal Year: 2001..These data will allow us to address the questions posed above, and thus improve our understanding of the behavior of primary visual cortex under natural conditions. ..
- REGULATION OF BBB GLUT1 GLUCOSE TRANSPORTERWilliam Pardridge; Fiscal Year: 2002..These studies will provide insight into molecular mechanisms of regulation of a step crucial to the maintenance of cerebral intermediary metabolism, i.e., the continuous transport of glucose across the blood-brain barrier in vivo. ..
- CEREBELLUM--ROLE IN THE CHEMICAL CONTROL OF BREATHINGFadi Xu; Fiscal Year: 2003..Perhaps, more exciting is the emerging concept that the cerebellum may be far more involved in the planning and executing of motor responses, including respiration, than we have heretofore imagined. ..
- AIDS Neurotherapeutics and BBB Drug EffluxWilliam Pardridge; Fiscal Year: 2007..This work provides the basis for future drug discovery of AET blockers, which can be used as co-drugs to increase CNS penetration of HAART drugs. ..
- Chromatin-based cellular memory in neural stem cellsDaniel Lim; Fiscal Year: 2009..Furthermore, our studies may lead to discoveries of how derangements in chromatin remodeling can lead to the development of brain tumors. ..
- Regulation of VEGF/HIF-1 by AKT: Implications for RadiotherapyAmit Maity; Fiscal Year: 2010..Increased oxygenation should make tumors more sensitive to radiation;therefore, our studies may be important in helping to optimize the combination of EGFR inhibitors with radiation. ..
- TOPOTECAN BY INTRACEREBRAL CLYSIS FOR BRAIN TUMORSJeffrey Bruce; Fiscal Year: 2006..abstract_text> ..
- LENTIVIRAL DELIVERY OF GDNF AND BCL-2 IN PD MODELMarina Emborg; Fiscal Year: 2003..These studies will serve as the preclinical foundation to determine whether this in vivo method to deliver these potent trophic factor and antiapoptotic genes will be suitable for testing in patients with PD. ..
- Adenoviral GFP targeting of metastatic human tumors using multiple delivery routeHiroyuki Kishimoto; Fiscal Year: 2008..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
- Differential Gene Expression in the Cochlear NucleusDavid Friedland; Fiscal Year: 2008..These data will also provide a powerful template upon which to test and design novel treatments for improving hearing, discrimination and tinnitus in a significant portion of the population. ..
- Non-Viral Gene Targeting to the BrainWilliam Pardridge; Fiscal Year: 2008..abstract_text> ..
- Age-Dependent Response of Hippocampal Neurons to StressGregory Brewer; Fiscal Year: 2006..abstract_text> ..
- Participating Member Institution in NABTCLisa DeAngelis; Fiscal Year: 2008..abstract_text> ..
- Orthotopic models of tumor angiogenesis and blood flowMeng Yang; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Targeted tumoricidal bacteriaMing Zhao; Fiscal Year: 2007..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
- Ninth International Conference on the Chemistry and Biology of Mineralized TissuePaul Krebsbach; Fiscal Year: 2007..The ensuing "cross pollenization" of perspective and expertise is the ideal venue to enhance the process of discovery in this important field. [unreadable] [unreadable] [unreadable]..
- Central Mechanisms of Respiratory ArrestFadi Xu; Fiscal Year: 2007..unreadable] [unreadable]..