Summary: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.

Top Publications

  1. pmc Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
    Troy D Querec
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Immunol 10:116-25. 2009
  2. ncbi Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
    Christophe J Desmet
    Laboratory of Cellular and Molecular Immunology, GIGA Research and Faculty of Veterinary Medicine, B34, University of Liege, 1 Avenue de l Hopital, B 4000 Liege, Belgium
    Nat Rev Immunol 12:479-91. 2012
  3. ncbi Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    D Schenk
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 400:173-7. 1999
  4. ncbi Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    Punnee Pitisuttithum
    Department of Clinical Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Infect Dis 194:1661-71. 2006
  5. pmc Systems biology of vaccination for seasonal influenza in humans
    Helder I Nakaya
    Emory Vaccine Center, Emory University, Atlanta, Georgia, USA
    Nat Immunol 12:786-95. 2011
  6. pmc Induction of immunity to human immunodeficiency virus type-1 by vaccination
    M Juliana McElrath
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D3 100, Seattle, WA 98109, USA
    Immunity 33:542-54. 2010
  7. pmc Immunological mechanisms of vaccination
    Bali Pulendran
    Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Nat Immunol 12:509-17. 2011
  8. pmc Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys
    Jinyan Liu
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 457:87-91. 2009
  9. pmc Recent progress in West Nile virus diagnosis and vaccination
    Marina De Filette
    Laboratory of Gene Therapy, Faculty of Veterinary Sciences, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium
    Vet Res 43:16. 2012
  10. ncbi Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: insights for understanding the impact of rotavirus vaccination programs
    Krisztian Banyai
    Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary
    Vaccine 30:A122-30. 2012

Detail Information

Publications373 found, 100 shown here

  1. pmc Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
    Troy D Querec
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Immunol 10:116-25. 2009
    ..b>Vaccination induced genes that regulate virus innate sensing and type I interferon production...
  2. ncbi Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
    Christophe J Desmet
    Laboratory of Cellular and Molecular Immunology, GIGA Research and Faculty of Veterinary Medicine, B34, University of Liege, 1 Avenue de l Hopital, B 4000 Liege, Belgium
    Nat Rev Immunol 12:479-91. 2012
    The demand is currently high for new vaccination strategies, particularly to help combat problematic intracellular pathogens, such as HIV and malarial parasites...
  3. ncbi Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    D Schenk
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 400:173-7. 1999
    ..Our results raise the possibility that immunization with amyloid-beta may be effective in preventing and treating Alzheimer's disease...
  4. ncbi Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    Punnee Pitisuttithum
    Department of Clinical Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Infect Dis 194:1661-71. 2006
  5. pmc Systems biology of vaccination for seasonal influenza in humans
    Helder I Nakaya
    Emory Vaccine Center, Emory University, Atlanta, Georgia, USA
    Nat Immunol 12:786-95. 2011
    Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons...
  6. pmc Induction of immunity to human immunodeficiency virus type-1 by vaccination
    M Juliana McElrath
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D3 100, Seattle, WA 98109, USA
    Immunity 33:542-54. 2010
  7. pmc Immunological mechanisms of vaccination
    Bali Pulendran
    Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Nat Immunol 12:509-17. 2011
    ..Here we will discuss these advances and emerging themes on the immunology of vaccination.
  8. pmc Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys
    Jinyan Liu
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 457:87-91. 2009
    ..These findings have important implications for the development of next-generation T-cell-based vaccine candidates for HIV-1...
  9. pmc Recent progress in West Nile virus diagnosis and vaccination
    Marina De Filette
    Laboratory of Gene Therapy, Faculty of Veterinary Sciences, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium
    Vet Res 43:16. 2012
    ..This review describes the molecular virology, epidemiology, pathogenesis, and highlights recent progress regarding diagnosis and vaccination against WNV infections.
  10. ncbi Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: insights for understanding the impact of rotavirus vaccination programs
    Krisztian Banyai
    Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary
    Vaccine 30:A122-30. 2012
  11. ncbi The revised global yellow fever risk map and recommendations for vaccination, 2010: consensus of the Informal WHO Working Group on Geographic Risk for Yellow Fever
    Emily S Jentes
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet Infect Dis 11:622-32. 2011
    ..for yellow fever virus transmission, to update yellow fever risk maps, and to revise the recommendations for vaccination for international travel...
  12. pmc Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites
    Noah S Butler
    Department of Microbiology, University of Iowa, 3 512 Bowen Science Building, Iowa City, IA 52242, USA
    Cell Host Microbe 9:451-62. 2011
  13. ncbi Immune response after a single vaccination against 2009 influenza A H1N1 in USA: a preliminary report of two randomised controlled phase 2 trials
    Eric Plennevaux
    Clinical Development Department, Sanofi Pasteur, Lyon, France
    Lancet 375:41-8. 2010
    ..from large clinical trials of paediatric, adult, and elderly people to find the appropriate antigen dose and vaccination schedule for the 2009 pandemic influenza A H1N1...
  14. ncbi Antibody response to influenza vaccination in the elderly: a quantitative review
    Katherine Goodwin
    National Institutes of Allergy and Infectious Diseases, Office of Global Affairs, 6610 Rockledge Drive, Room 2033, Bethesda, MD 20818, USA
    Vaccine 24:1159-69. 2006
    ..We conclude that the antibody response in the elderly is considerably lower than in younger adults. This highlights the need for more immunogenic vaccine formulations for the elderly...
  15. pmc Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
    Denis Gaucher
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal CR CHUM Saint Luc, Montreal, Quebec, Canada
    J Exp Med 205:3119-31. 2008 the yellow fever (YF) vaccine 17D (YF17D) in a cohort of 40 volunteers followed for up to 1 yr after vaccination. We show that immunization with YF17D leads to an integrated immune response that includes several effector ..
  16. ncbi Herpes zoster incidence among insured persons in the United States, 1993-2006: evaluation of impact of varicella vaccination
    Jessica Leung
    National Center for Immunization and Respiratory Diseases NCIRD, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
    Clin Infect Dis 52:332-40. 2011 introduction of HZ vaccine is not well described, and it is unclear whether introduction of the varicella vaccination program in 1995 has altered the epidemiology of HZ...
  17. ncbi Effect of a text messaging intervention on influenza vaccination in an urban, low-income pediatric and adolescent population: a randomized controlled trial
    Melissa S Stockwell
    Department of Pediatrics, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    JAMA 307:1702-8. 2012
    Influenza infection results in substantial costs, morbidity, and mortality. Vaccination against influenza is particularly important in children and adolescents who are a significant source of transmission to other high-risk populations, ..
  18. ncbi Optimizing influenza vaccine distribution
    Jan Medlock
    Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Science 325:1705-8. 2009
    ..We find that optimal vaccination is achieved by prioritization of schoolchildren and adults aged 30 to 39 years...
  19. pmc Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    J Transl Med 10:141. 2012
  20. ncbi Induction of broadly neutralizing H1N1 influenza antibodies by vaccination
    Chih Jen Wei
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892 3005, USA
    Science 329:1060-4. 2010
    ..Here, we show that vaccination with plasmid DNA encoding H1N1 influenza hemagglutinin (HA) and boosting with seasonal vaccine or replication-..
  21. ncbi From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine
    Bruno Guy
    Research and Development, Sanofi Pasteur, 69280 Marcy l Etoile, France
    Vaccine 29:7229-41. 2011
    ..A three-dose vaccination regimen induces an immune response against all four serotypes in the large majority of vaccinees...
  22. ncbi The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns
    Leonoor Wijnans
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Vaccine 31:1246-54. 2013
    ..In response to this signal, the background rates of narcolepsy in Europe were assessed to rapidly provide information for signal verification...
  23. pmc Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore
    Luis R Carrasco
    Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore
    PLoS Negl Trop Dis 5:e1426. 2011
    ..5 billion people in the tropical and subtropical regions. Little is known about the disease burden and economic impact of dengue in higher resourced countries or the cost-effectiveness of potential dengue vaccines in such settings...
  24. ncbi Reasons related to non-vaccination and under-vaccination of children in low and middle income countries: findings from a systematic review of the published literature, 1999-2009
    Jeanette J Rainey
    US Centers for Disease Control and Prevention, Global Immunization Division, USA
    Vaccine 29:8215-21. 2011
    Despite increases in routine vaccination coverage during the past three decades, the percent of children completing the recommended vaccination schedule remains below expected targets in many low and middle income countries...
  25. pmc Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
    Markku Partinen
    Helsinki Sleep Clinic, Vitalmed Research Centre, Helsinki, Finland
    PLoS ONE 7:e33723. 2012
    ..Therefore, we carried out a systematic analysis of the incidence of narcolepsy in Finland between the years 2002-2010...
  26. pmc Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1
    Stephen Mark Tompkins
    Food and Drug Administration, Bethesda, Maryland, USA
    Emerg Infect Dis 13:426-35. 2007
    ..This vaccination induced antibodies that cross-reacted with divergent M2 peptide from an H5N1 subtype...
  27. ncbi HPV vaccine acceptability in Ghana, West Africa
    Maame Aba Coleman
    Baylor College of Medicine, Department of Obstetrics and Gynecology, Houston, TX 77030, USA
    Vaccine 29:3945-50. 2011
    Cervical cancer is a leading cause of cancer-related mortality among women in Ghana. As of this writing no data are available concerning knowledge, attitudes and acceptability of human papillomavirus (HPV) vaccination by women in Ghana.
  28. ncbi Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong
    Benjamin J Cowling
    Infectious Disease Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Infect Dis 51:1370-9. 2010
    ..The relationship between seasonal influenza vaccine and susceptibility to 2009 pandemic A/H1N1 virus infection is not fully understood...
  29. ncbi Report from a WHO Working Group: standard method for detecting upper respiratory carriage of Streptococcus pneumoniae
    Katherine L O'Brien
    Pediatr Infect Dis J 22:e1-11. 2003
    ..Numerous studies evaluating the efficacy of conjugate pneumococcal vaccines are being conducted or planned throughout the world. Some of these studies are evaluating the effect of vaccine on nasopharyngeal (NP) carriage...
  30. ncbi Safety and immunogenicity of 2009 pandemic influenza A H1N1 vaccines in China: a multicentre, double-blind, randomised, placebo-controlled trial
    Xiao Feng Liang
    Chinese Center for Disease Control and Prevention, Beijing, China
    Lancet 375:56-66. 2010
    ..The current influenza pandemic calls for a safe and effective vaccine. We assessed the safety and immunogenicity of eight formulations of 2009 pandemic influenza A H1N1 vaccine produced by ten Chinese manufacturers...
  31. ncbi Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009
    Anthony E Fiore
    Influenza Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 58:1-52. 2009
    ..MMWR 2008;57[No. RR-7]). Information on vaccination issues related to the recently identified novel influenza A H1N1 virus will be published later in 2009...
  32. ncbi Measuring human papillomavirus (HPV) vaccination coverage and the role of the National HPV Vaccination Program Register, Australia
    Dorota M Gertig
    Victorian Cytology Service, PO Box 161, Carlton South, VIC 3053, Australia
    Sex Health 8:171-8. 2011
    Accurate estimates of HPV vaccination coverage are critical for determining the proportion of the target female population that is not protected by the vaccine, as well as for monitoring the performance of vaccine delivery programs...
  33. pmc Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study
    Stefan Flasche
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS Med 8:e1001017. 2011
  34. pmc Pre-vaccination nasopharyngeal pneumococcal carriage in a Nigerian population: epidemiology and population biology
    Ifedayo M O Adetifa
    Medical Research Council Unit, The Gambia, Fajara, The Gambia
    PLoS ONE 7:e30548. 2012
    ..This study was carried out to describe the pre vaccination epidemiology and population biology of pneumococcal carriage in Nigeria.
  35. pmc Vaccination strategies for epidemic cholera in Haiti with implications for the developing world
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 108:7081-5. 2011
    ..reduced morbidity and mortality, but such vaccines are in short supply and little is known about effective vaccination strategies for epidemic cholera...
  36. pmc Current status of vaccines for schistosomiasis
    Donald P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane Q4006, Australia
    Clin Microbiol Rev 21:225-42. 2008
    ..haematobium) and Asian (S. japonicum) schistosomes is then discussed, as are new approaches that may improve the efficacy of available vaccines and aid in the identification of new targets for immune attack...
  37. ncbi The near disappearance of genital warts in young women 4 years after commencing a national human papillomavirus (HPV) vaccination programme
    Tim R H Read
    Department of Public Health, Melbourne Sexual Health Centre, Alfred Hospital and School of Population Health, University of Melbourne, Carlton, Victoria, Australia
    Sex Transm Infect 87:544-7. 2011
    ..Australia provided free quadrivalent human papillomavirus vaccines to 12-18-year-old girls and women aged ≤26 years from mid-2007 until the end of 2009. After this time, only girls aged 12-13 years had access to free vaccines...
  38. pmc Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
    Jens Wrammert
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 453:667-71. 2008
    ..Here we report that after booster vaccination there was a rapid and robust influenza-specific IgG+ antibody-secreting plasma cell (ASC) response that peaked ..
  39. pmc Prevalence of seroprotection against the pandemic (H1N1) virus after the 2009 pandemic
    Danuta M Skowronski
    BC Centre for Disease Control, Vancouver, BC
    CMAJ 182:1851-6. 2010
    ..We reassessed this profile of seroprotection by age in the same region six months after the fall 2009 pandemic and vaccination campaign.
  40. pmc Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination
    Viggo F Van Tendeloo
    University of Antwerp, Faculty of Medicine, Vaccine and Infectious Disease Institute Vaxinfectio and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp B 2650, Belgium
    Proc Natl Acad Sci U S A 107:13824-9. 2010
    ..Here, in a phase I/II trial, we investigated the effect of autologous dendritic cell vaccination in 10 patients with acute myeloid leukemia (AML)...
  41. ncbi Prime-boost vectored malaria vaccines: progress and prospects
    Adrian V S Hill
    The Jenner Institute, University of Oxford, Oxford, UK
    Hum Vaccin 6:78-83. 2010
    ..Such vectored vaccination regimes represent one of only two approaches that have induced repeatable partial efficacy in human P...
  42. ncbi Exploiting the mutanome for tumor vaccination
    John C Castle
    TRON Translational Oncology at the University Medical Center Mainz, Germany
    Cancer Res 72:1081-91. 2012
    ..gene mutations derived from clonal heterogeneity therefore represents an ideal setting for multiepitope tumor vaccination. Here, we used next generation sequencing exome resequencing to identify 962 nonsynonymous somatic point ..
  43. ncbi Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites
    Philip Bejon
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom
    J Infect Dis 191:619-26. 2005
    ..Forty-eight-hour growth rates in blood from control subjects were not different from those in blood from any vaccination group (mean, 14.4-fold [95% confidence interval, 11-19-fold]).
  44. ncbi Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period?
    Peter Aaby
    Bandim Health Project, INDEPTH Network, Bissau, Guinea Bissau
    J Infect Dis 204:245-52. 2011
    ..Low-birth-weight (LBW) children are not given BCG at birth in Guinea-Bissau; we conducted a randomized trial of BCG at birth (early BCG) vs delayed BCG...
  45. ncbi A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    D Morgan
    Department of Pharmacology, University of South Florida, Tampa 33612, USA
    Nature 408:982-5. 2000
    ..if the vaccinations had deleterious or beneficial functional consequences, we tested eight months of A beta vaccination in a different transgenic model for Alzheimer's disease in which mice develop learning deficits as amyloid ..
  46. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ..the immunizing functions of maturing dendritic cells, antibody-mediated antigen targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity, including systemic and mucosal resistance in disease models.
  47. ncbi A mathematical model to estimate global hepatitis B disease burden and vaccination impact
    Susan T Goldstein
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Int J Epidemiol 34:1329-39. 2005
    Limited data are available regarding global hepatitis B virus (HBV)-related morbidity and mortality and potential reduction in disease burden from hepatitis B vaccination.
  48. ncbi Vaccination against pandemic influenza A/H1N1v in England: a real-time economic evaluation
    Marc Baguelin
    Centre for Infections, Health Protection Agency, United Kingdom
    Vaccine 28:2370-84. 2010
    ..We present a real-time assessment of the effectiveness and cost-effectiveness of alternative influenza A/H1N1v vaccination strategies...
  49. ncbi Vaccine-derived polioviruses and the endgame strategy for global polio eradication
    Olen M Kew
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Microbiol 59:587-635. 2005
    ..Developing a posteradication strategy to minimize the risks of VDPV emergence and spread has become an urgent WHO priority...
  50. ncbi Quadrivalent human papillomavirus vaccination and trends in genital warts in Australia: analysis of national sentinel surveillance data
    Basil Donovan
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, Australia
    Lancet Infect Dis 11:39-44. 2011
    ..From July, 2007, Australia was the first country to fund a vaccination programme for all women aged 12-26 years...
  51. ncbi Quadrivalent Human Papillomavirus Vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP)
    Lauri E Markowitz
    Division of STD Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention Proposed, Atlanta, GA 30333, USA
    MMWR Recomm Rep 56:1-24. 2007
    ..HPV and associated diseases, describes the licensed HPV vaccine, and provides recommendations for its use for vaccination among females aged 9-26 years in the United States...
  52. ncbi Timing of children's vaccinations in 45 low-income and middle-income countries: an analysis of survey data
    Andrew Clark
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 373:1543-9. 2009
    ..We estimated vaccination coverage at different ages, and delays in administration, in 45 low-income and middle-income countries.
  53. pmc HIV vaccines: lessons learned and the way forward
    Jerome H Kim
    Walter Reed Army Institute of Research, U S Military HIV Research Program, Rockville, Maryland, USA
    Curr Opin HIV AIDS 5:428-34. 2010
    ..An effective HIV vaccine is a global health priority. We describe lessons learned from four HIV vaccine trials that failed to demonstrate efficacy and one that showed modest protection as a pathway forward...
  54. ncbi Safety and immunogenicity of a 2009 pandemic influenza A H1N1 vaccine when administered alone or simultaneously with the seasonal influenza vaccine for the 2009-10 influenza season: a multicentre, randomised controlled trial
    Zoltan Vajo
    University of Debrecen, Medical and Health Sciences Centre, Debrecen, Hungary
    Lancet 375:49-55. 2010
    ..We investigated the safety and immunogenicity of a whole-virion, inactivated, adjuvanted pandemic H1N1 vaccine in adult and elderly volunteers, given without or simultaneously with the 2009-10 seasonal trivalent influenza vaccine...
  55. pmc Heterologous prime-boost vaccination
    Shan Lu
    China US Vaccine Research Center and Department of Infectious Diseases, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
    Curr Opin Immunol 21:346-51. 2009
    ..Heterologous prime-boost represents a new way of immunization and will stimulate better understanding on the immunological basis of vaccines...
  56. ncbi Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine in women aged 24-45 years: a randomised, double-blind trial
    Nubia Munoz
    National Institute of Cancer, Bogota, Colombia
    Lancet 373:1949-57. 2009
    ..We tested the safety, immunogenicity, and efficacy of the quadrivalent HPV (types 6, 11, 16, 18) L1 virus-like-particle vaccine in women aged 24-45 years...
  57. ncbi Impact of the implementation of a vaccination strategy on hepatitis B virus infections in China over a 20-year period
    Zhuanbo Luo
    National Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qing Chun Road, Hangzhou 310003, People s Republic of China
    Int J Infect Dis 16:e82-8. 2012
    Hepatitis B virus (HBV) vaccination has been recommended for all neonates in China since 1992. This article reviews the impact of HBV vaccination throughout the past 20 years in China...
  58. ncbi A simple model for complex dynamical transitions in epidemics
    D J Earn
    Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Science 287:667-70. 2000
    ..A simple model can explain both kinds of transitions as the consequences of changes in birth and vaccination rates...
  59. pmc Efficacy of a low-cost, inactivated whole-cell oral cholera vaccine: results from 3 years of follow-up of a randomized, controlled trial
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    PLoS Negl Trop Dis 5:e1289. 2011
    ..Killed oral cholera vaccines (OCVs) have been licensed for use in developing countries, but protection conferred by licensed OCVs beyond two years of follow-up has not been demonstrated in randomized, clinical trials...
  60. ncbi A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea
    Blaise Genton
    Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    J Infect Dis 185:820-7. 2002
    ..The vaccine-induced selection pressure exerted on the parasites and its consequences for morbidity strongly argue for developing vaccines comprising conserved antigens and/or multiple components covering all important allelic types...
  61. pmc Text4Health: impact of text message reminder-recalls for pediatric and adolescent immunizations
    Melissa S Stockwell
    Division of Child and Adolescent Health and the Heilbrunn Department of Population and Family Health, Columbia University, New York, NY, USA
    Am J Public Health 102:e15-21. 2012
    ..We conducted 2 studies to determine the impact of text message immunization reminder-recalls in an urban, low-income population...
  62. pmc What led to the Nigerian boycott of the polio vaccination campaign?
    Ayodele Samuel Jegede
    University of Toronto Joint Centre for Bioethics, Toronto, ON, Canada
    PLoS Med 4:e73. 2007
  63. pmc Factors affecting intention to receive and self-reported receipt of 2009 pandemic (H1N1) vaccine in Hong Kong: a longitudinal study
    Qiuyan Liao
    Health Behaviours Research Group, Department of Community Medicine and School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China
    PLoS ONE 6:e17713. 2011
    b>Vaccination was a core component for mitigating the 2009 influenza pandemic (pH1N1). However, a vaccination program's efficacy largely depends on population compliance...
  64. pmc Knowledge and acceptability of pap smears, self-sampling and HPV vaccination among adult women in Kenya
    Anne F Rositch
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e40766. 2012
    ..Our study aimed to assess adult women's knowledge of human papillomavirus (HPV) and cervical cancer, and characterize their attitudes towards potential screening and prevention strategies...
  65. ncbi The dynamics of measles in sub-Saharan Africa
    Matthew J Ferrari
    Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 451:679-84. 2008
    Although vaccination has almost eliminated measles in parts of the world, the disease remains a major killer in some high birth rate countries of the Sahel...
  66. ncbi Whole parasite vaccination approaches for prevention of malaria infection
    Noah S Butler
    Department of Microbiology, University of Iowa, Iowa City, IA, USA
    Trends Immunol 33:247-54. 2012
    ..This model gave the rationale for development of recombinant and vectored subunit vaccination strategies that have, however, not yet matched whole sporozoite protective efficacy...
  67. pmc Social determinants of health and seasonal influenza vaccination in adults ≥65 years: a systematic review of qualitative and quantitative data
    Jason M Nagata
    Social Determinants of Health, Department of Ethics and Social Determinants, World Health Organization, 20 Avenue Appia, Geneva, CH 1211, Switzerland
    BMC Public Health 13:388. 2013
    b>Vaccination against influenza is considered the most important public health intervention to prevent unnecessary hospitalizations and premature deaths related to influenza in the elderly, though there are significant inequities among ..
  68. pmc Risk factors for incomplete vaccination and missed opportunity for immunization in rural Mozambique
    Jagrati V Jani
    Department of Immunology, Instituto Nacional de Saude, Maputo, Mozambique
    BMC Public Health 8:161. 2008
    ..Nonetheless, the reasons for incomplete vaccination and non-uptake of immunization services are poorly understood...
  69. pmc Human papillomavirus vaccination in Tanzanian schoolgirls: cluster-randomized trial comparing 2 vaccine-delivery strategies
    Deborah Watson-Jones
    London School of Hygiene and Tropical Medicine, London, UK
    J Infect Dis 206:678-86. 2012
    ..We compared vaccine coverage achieved by 2 different delivery strategies for the quadrivalent human papillomavirus (HPV) vaccine in Tanzanian schoolgirls...
  70. ncbi Active, population-based surveillance for severe rotavirus gastroenteritis in children in the United States
    Daniel C Payne
    Epidemiology Branch, Division of Viral Diseases, National Center for Immunizations and Respiratory Disease, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS A34, Atlanta, GA 30333, USA
    Pediatrics 122:1235-43. 2008
    Routine vaccination of US infants against rotavirus was implemented in 2006, prompting the Centers for Disease Control and Prevention New Vaccine Surveillance Network to begin population-based acute gastroenteritis surveillance among US ..
  71. ncbi Safety and immunogenicity study of a killed bivalent (O1 and O139) whole-cell oral cholera vaccine Shanchol, in Bangladeshi adults and children as young as 1 year of age
    Amit Saha
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Vaccine 29:8285-92. 2011
    ..Safety and immunogenicity study of an oral, killed, bivalent whole-cell, cholera vaccine, Shanchol was carried out in Bangladeshi participants. This study was conducted prior to initiating a feasibility study in Bangladesh...
  72. pmc Impact of pneumococcal conjugate vaccination of infants on pneumonia and influenza hospitalization and mortality in all age groups in the United States
    Lone Simonsen
    Sage Analytica, Bethesda, Maryland, USA
    MBio 2:e00309-10. 2011
    ..A model developed to calculate the total burden of pneumococcal pneumonia prevented by infant PCV7 vaccination in the United States from 2000 to 2006 estimated a reduction of 788,838 (CI, 695,406 to 875,476) ..
  73. ncbi Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australia's National Childhood vaccine schedule
    Jim P Buttery
    Department of General Medicine and Murdoch Children s Research Institute, Royal Children s Hospital Melbourne, Parkville, Victoria, Australia Paediatric Infectious Diseases Unit, Monash Children s Hospital, Department of Paediatrics, Monash University, Melbourne, Victoria
    Pediatr Infect Dis J 30:S25-9. 2011
    ..This allowed comparison of both vaccines in similar populations with high infant vaccination coverage.
  74. ncbi Factors associated with uptake of vaccination against pandemic influenza: a systematic review
    Alison Bish
    Department of Clinical, Educational and Health Psychology, University College London, 1 19 Torrington Place, London WC1E 7HB, UK
    Vaccine 29:6472-84. 2011
    In June 2009 a global influenza pandemic was declared by the World Health Organisation. A vaccination programme against H1N1 influenza was introduced in many countries from September 2009, but there was low uptake in both the general ..
  75. pmc Carriage of Streptococcus pneumoniae 3 years after start of vaccination program, the Netherlands
    Judith Spijkerman
    University Medical Center, Utrecht, The Netherlands
    Emerg Infect Dis 17:584-91. 2011
    ..PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination.
  76. ncbi The cost-effectiveness of male HPV vaccination in the United States
    Harrell W Chesson
    National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Vaccine 29:8443-50. 2011
    The objective of this study was to estimate the cost-effectiveness of adding human papillomavirus (HPV) vaccination of 12-year-old males to a female-only vaccination program for ages 12-26 years in the United States.
  77. pmc Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A
    Kristin L Griffiths
    The Jenner Institute, Oxford University, Oxford, United Kingdom
    PLoS ONE 6:e23463. 2011
    b>Vaccination with Bacille Calmette-Guérin (BCG) has traditionally been used for protection against disease caused by the bacterium Mycobacterium tuberculosis (M.tb)...
  78. ncbi Pneumococcal polysaccharide vaccination for adults: new perspectives for Europe
    David S Fedson
    57 Chemin du Lavoir, 01630 Sergy Haut, France
    Expert Rev Vaccines 10:1143-67. 2011
    b>Vaccination is the only public-health measure likely to reduce the burden of pneumococcal diseases...
  79. ncbi Breaking the chain: Rift Valley fever virus control via livestock vaccination
    Brian H Bird
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30333, USA
    Curr Opin Virol 2:315-23. 2012
    ..b>Vaccination programs targeting livestock during non-epidemic periods or as an early countermeasure against nascent ..
  80. ncbi Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
    Fang Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Ann Neurol 70:410-7. 2011
    ..Recently, concern has been raised over reports of narcolepsy in northern Europe following H1N1 vaccination.
  81. ncbi Insight into the immunobiology of human skin and functional specialization of skin dendritic cell subsets to innovate intradermal vaccination design
    M B M Teunissen
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Curr Top Microbiol Immunol 351:25-76. 2012
    ..The skin is an attractive site for vaccination given the extended local network of DCs and the easy access to the skin-draining lymph nodes to generate ..
  82. pmc Vaccination and the theory of games
    Chris T Bauch
    Department of Mathematics and Statistics, University of Guelph, Guelph, ON, Canada N1G 2W1
    Proc Natl Acad Sci U S A 101:13391-4. 2004
    Voluntary vaccination policies for childhood diseases present parents with a subtle challenge: if a sufficient proportion of the population is already immune, either naturally or by vaccination, then even the slightest risk associated ..
  83. ncbi Infant rotavirus vaccination may provide indirect protection to older children and adults in the United States
    Ben A Lopman
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 204:980-6. 2011
    Following the introduction of rotavirus vaccination in the United States, rotavirus and cause-unspecified gastroenteritis discharges significantly decreased in 2008 in the 0-4, 5-14, and 15-24-year age groups, with significant reductions ..
  84. pmc Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870
    Vega Masignani
    IRIS, Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy
    J Exp Med 197:789-99. 2003
    ..B meningococcus are devastating diseases of infants and young adults, which cannot yet be prevented by vaccination. By genome mining, we discovered GNA1870, a new surface-exposed lipoprotein of Neisseria meningitidis that ..
  85. ncbi Pathogenesis of chronic Chagas heart disease
    Jose Antonio Marin-Neto
    Cardiology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Circulation 115:1109-23. 2007
    ..Despite nearly 1 century of research, the pathogenesis of chronic Chagas cardiomyopathy is incompletely understood, the most intriguing challenge of which is the complex host-parasite interaction...
  86. ncbi Decrease of the incidence of human and canine visceral leishmaniasis after dog vaccination with Leishmune in Brazilian endemic areas
    Clarisa B Palatnik-de-Sousa
    Department of General Microbiology, Institute of Microbiology Prof Paulo de Góes, Federal University of Rio de Janeiro UFRJ, Rio de Janeiro, RJ, Brazil
    Vaccine 27:3505-12. 2009
    ..We demonstrate here that vaccination with Leishmune does not interfere with the serological control campaign (110,000 dogs). Only 1...
  87. ncbi Population and risk group uptake of H1N1 influenza vaccine in mainland France 2009-2010: results of a national vaccination campaign
    Angie Bone
    Institut de veille sanitaire French Institute for Public Health Surveillance, 12 Rue du Val d Osne, 94415 Saint Maurice Cedex, France
    Vaccine 28:8157-61. 2010
    A mass vaccination campaign against influenza A/H1N1 was launched in France in October 2009. Vaccination was offered free of charge to the entire population according to a pre-defined order of priority...
  88. ncbi Future vaccination strategies against tuberculosis: thinking outside the box
    Stefan H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
    Immunity 33:567-77. 2010
    ..Here, we review current and future strategies toward the rational design of novel vaccines against TB, as well as the progress made thus far, and the hurdles that need to be overcome in the near and distant future...
  89. pmc Economic evaluation of human papillomavirus vaccination in the United Kingdom
    Mark Jit
    Modelling and Economics Unit, Centre for Infections, Health Protection Agency, London NW9 6BT
    BMJ 337:a769. 2008
    To assess the cost effectiveness of routine vaccination of 12 year old schoolgirls against human papillomavirus infection in the United Kingdom.
  90. ncbi Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus
    Olen Kew
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention CDC, 1600 Clifton Road, Atlanta, GA 30333, USA
    Science 296:356-9. 2002
    ..The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus...
  91. ncbi The aging of the immune system
    Daniela Weiskopf
    Immunology Division, Institute for Biomedical Aging Research, Innsbruck, Austria
    Transpl Int 22:1041-50. 2009
    ..partially responsible for the increased prevalence and severity of infectious diseases, and the low efficacy of vaccination in elderly persons...
  92. ncbi Global status of Haemophilus influenzae type b and pneumococcal conjugate vaccines: evidence, policies, and introductions
    Orin S Levine
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, International Vaccine Access Center, Baltimore, Maryland, USA
    Curr Opin Infect Dis 23:236-41. 2010
    ..This study reviews the status of vaccine use globally and the evidence base that supports policy recommendations for use of these vaccines in children...
  93. pmc Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination
    Bruna C G de Alencar
    Centro Interdisciplinar de Terapia Gênica CINTERGEN, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Mirassol 207, Sao Paulo, SP 04044 010, Brazil
    Infect Immun 77:4383-95. 2009
    ..Our study thus demonstrated a role for perforin and IFN-gamma in a number of T-cell-mediated effector functions and in the antiparasitic immunity generated by a heterologous plasmid DNA prime-adenovirus boost vaccination strategy.
  94. ncbi Vaccines and vaccination strategies against human cutaneous leishmaniasis
    Ifeoma Okwor
    Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, CA
    Hum Vaccin 5:291-301. 2009
    ..However, there is as yet no effective vaccine against the disease in humans. Although vaccination in murine studies has yielded promising results, these vaccines have failed miserably when tested in primates ..
  95. pmc From vaccines to memory and back
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Immunity 33:451-63. 2010
    ..immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies...
  96. pmc Regulation of antinucleoprotein IgG by systemic vaccination and its effect on influenza virus clearance
    Mark W Lamere
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Virol 85:5027-35. 2011
    ..The high conservation of NP antigen and the known longevity of antibody responses suggest that the antiviral activity of anti-NP IgG may provide a critically needed component of a universal influenza vaccine...
  97. ncbi Haemophilus influenzae: a significant pathogen in acute otitis media
    Eugene Leibovitz
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 23:1142-52. 2004
    ..influenzae from the middle ear space. In the United States, widespread pneumococcal vaccination has increased the importance of H. influenzae as a major therapeutic challenge in the treatment of AOM.
  98. ncbi Tularemia as a biological weapon: medical and public health management
    D T Dennis
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
    JAMA 285:2763-73. 2001
    ..The Working Group on Civilian Biodefense has developed consensus-based recommendations for measures to be taken by medical and public health professionals if tularemia is used as a biological weapon against a civilian population...
  99. ncbi Tutorial in biostatistics: the self-controlled case series method
    Heather J Whitaker
    Department of Statistics, The Open University, Milton Keynes, MK7 6AA, UK
    Stat Med 25:1768-97. 2006
    ..Some brief pointers on the design of case series studies are provided. The data sets, STATA code, and further implementation details in SAS, GENSTAT and GLIM are available from an associated website...
  100. pmc 7-Valent pneumococcal conjugate vaccination in England and Wales: is it still beneficial despite high levels of serotype replacement?
    Yoon Hong Choi
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS ONE 6:e26190. 2011
    The UK introduced the 7-valent pneumococcal conjugate vaccine (PCV7) into the national vaccination program in September 2006...
  101. pmc The HIV/AIDS vaccine candidate MVA-B administered as a single immunogen in humans triggers robust, polyfunctional, and selective effector memory T cell responses to HIV-1 antigens
    Carmen Elena Gómez
    Centro Nacional de Biotecnologia, CSIC, Madrid 28049, Spain
    J Virol 85:11468-78. 2011
    ..proportion of responders after two doses of MVA-B was similar to that obtained after the third dose of MVA-B vaccination, and the responses were sustained (84.6% at week 48)...

Research Grants75

  1. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    Project Summary Prior to implementing universal childhood vaccination in Alaska, rates of hepatitis A in Alaska Native persons were more than five times higher than those in other racial/ethnic populations...
  2. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..dysenteriae 1 and longevity of the responses to vaccination in humans, (3) To evaluate the effects of immunization of monkeys with attenuated S...
  3. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..A different anti-AD strategy, vaccination with the A( peptide, also reduces A( deposition in AD transgenic mice and improves cognition...
  4. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
    ..Currently, live attenuated TC-83 vaccine is used under IND protocol for vaccination of personnel at risk...
  5. Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanoma
    ANDREW GREGORY SIKORA; Fiscal Year: 2013
    ..targeted inhibition of iNOS with small-molecule chemical antagonists will enhance the response to anti-tumor vaccination by suppressing the recruitment and suppressive capacity of intratumoral MDSC...
  6. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ..PROJECT 1: Human CD8+ and CD4+ T Cells Responses to Influenza Infection and Vaccination (TERAJIMA, M) PROJECT 1 The overall goal of this project is to define the human T-cell responses to influenza ..
  7. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..supported the infrastructure services are finding: 1) an effective community-based hepatitis B testing and vaccination intervention, 2) an effective cervical cancer screening lay health worker intervention model for sexually ..
  8. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012 gene carrier;however, induction of self-immunity is still the hurdle in using HEV-VLP for therapeutical vaccination. Our studies on HEV-VLP crystal structure and antigenic structure reveal a structural modularity, with which ..
  9. Development of Vaccines against Clostridium difficile Infection
    SAUL R TZIPORI; Fiscal Year: 2013
    ..Preliminary studies showed that atoxic TcdB vaccination induced antibody responses against a wide-spectrum of epitopes and potent protective immunity superior to ..
  10. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..immunity, (b) ability to induce protective immunity against specific enteric pathogens, (c) consequences of vaccination on normal flora, (d) efficacy of mixtures of vaccines to protect against Salmonella and one or two other ..
    Rafi Ahmed; Fiscal Year: 2013
    ..the cellular basis of immune senescence and develop strategies for improving responses of the elderly to vaccination. A major emphasis of this proposal was to use genomics to define molecular signatures of a successful vaccine, ..
  12. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..In preliminary data, we found that T17 cells also are induced by vaccination and confer resistance against B...
  13. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..The immune response to infection or vaccination is the outcome of such a complex network of positive and negative regulatory pathways that it is often ..
  14. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..that can 1) be used to express proteins in cultured cells, 2) be used to directly vaccinate animals (genetic vaccination), and 3) serve as templates to direct cell-free in vitro transcription and translation reactions that yield ..
  15. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..pattern of young animals, will ameliorate major biomarkers of immune senescence and improve T cell responses to vaccination. We will first determine the impact of physiological androgen supplementation on the severity of immune ..
  16. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..proposed studies testing the impact of DM on the secondary response to Mtb in clinically relevant models of BCG vaccination and antimicrobial therapy...
  17. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    Aging is associated with decreased efficacy of vaccination, and increased morbidity and mortality following infection by agents such as pneumococcus, influenza and West Nile virus...
  18. Modulation of host immune defense by Pneumocystis beta-glucans
    ..In addition, we expect to develop a mouse model of Pneumocystis vaccination that could potentially be translated to human use...
  19. Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B Cells
    HARRY BERNARD GREENBERG; Fiscal Year: 2010
    ..a critical component of the influenza mucosal immunity, traditional analyses of B cell immunity after influenza vaccination have been largely limited to studies of serum antibodies, which do not provide adequate or unified markers for ..
  20. Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast Milk
    Lynn Puddington; Fiscal Year: 2010
    ..Susceptible individuals share significant challenges for vaccination, as they are less competent to generate long-term protective immunity...
  21. Mechanism of Translation Elongation Factor 2 Inhibition by Bacterial Toxins
    Terri Goss Kinzy; Fiscal Year: 2010
    ..In the developing world Diphtheria remains a significant health concern, even with vaccination campaigns...
  22. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..Immune based therapies with the potential to benefit IA include vaccination and adoptive T cell transfers...
  23. Host Defense Mechanisms in Polyaromatic Hydrogen Carcinogenesis
    Craig A Elmets; Fiscal Year: 2013
    ..Based on these findings, we hypothesize that vaccination strategies resulting T-cell mediated immunity to oncogene mutations produced by polyaromatic hydrocarbons ..
  24. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..HIFU would be used to ablate the local tumor and release tumor-derived HSPs and peptides for an in situ auto-vaccination. In a recently completed phase I SBIR proposal (PI, Naren Sanghvi, Focus Surgery), we demonstrated that cycles ..
  25. Expression signatures of TB-specific memory responses within the human lung
    Richard F Silver; Fiscal Year: 2013
    ..understanding of local immunity to Mtb within the human lung is critical to development of more effective TB vaccination programs, and, more generally, to understanding the mechanisms by which cell-mediated immunity functions within ..
  26. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..These live vaccines stimulate robust humoral and cell-mediated immunity that can persist for decades after vaccination. Despite their effectiveness, there are disadvantages of using live attenuated vaccines, which include ..
  27. Preclinical studies of a heroin/morphine vaccine for opiate addiction
    Paul R Pentel; Fiscal Year: 2013
    ..b>Vaccination with M-TT elicits high concentrations of high affinity antibodies, and robustly blocks heroin or morphine self- ..
  28. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..b>Vaccination with recombinant MSCRAMMs or inhibition of their functions resulted in significant protection against disease...
  29. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..This, our most successful vaccination modality, has not been adequately considered for its potential to control genital herpes...
  30. Predictors of Immunologic Failure in Older Adults
    David H Canaday; Fiscal Year: 2012
    ..It has been established that increasing age leads to both immunologic dysfunction and poor responses to vaccination. The overall hypothesis that frailty and age predict immunologic and vaccination failure in older adults...
  31. Protective orthopox immunization in normals and patients with cancer or eczema
    Ellis Reinherz; Fiscal Year: 2009
    ..with cancer and eczema, comprise a large percentage of the US population, mandating against massive large-scale vaccination. Recent developments in immunology, both with regard to mechanistic understanding of adaptive and innate immune ..
  32. Prevention and therapy of Staphylococcus aureus infections
    Olaf Schneewind; Fiscal Year: 2010
    ..Science Discoveries into New and Better Treatments) through the invention of a novel treatment - therapeutic vaccination - for human MRSA infections...
  33. The human gut microbiome, malnutrition and vaccine responses
    ANDREW LEON KAU; Fiscal Year: 2013
    ..I will follow their responses to mucosal vaccination with cholera toxin and ovalbumin (a model mucosal adjuvant/antigen) using antigen-specific ELISA...
  34. Complement Activation on Neisseria meningitidis
    Sanjay Ram; Fiscal Year: 2013
    ..The emergence of disease caused by strains that lack a capsule following vaccination campaigns using capsular polysaccharide-based vaccines is of concern...
  35. Multivalent Vaccine for Opiate Addiction
    Paul R Pentel; Fiscal Year: 2012
    ..Vaccines have been developed for nicotine or cocaine addiction whereby vaccination stimulates the production of antibodies that can bind the addictive drug and reduce the amount that reaches ..
  36. Host defense against poxviruses and viral immune evasion
    Liang Deng; Fiscal Year: 2011
    ..system are of importance because of the threat of using smallpox as a bioterror weapon, the need for improved vaccination strategies to minimize vaccine-associated complications, such as eczema vaccinatum, and the reimmergence of ..
  37. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012
    ..Second objective will be to examine the potential of a protective prophylactic vaccination strategy as a therapeutic treatment modality in an attempt to resolve a chronic parasitic infection and ..
  38. Lung and bone marrow crosstalk during a respiratory infection
    CAROLINA B LOPEZ; Fiscal Year: 2010
    ..compartments could create novel modes of intervention for the modulation of mucosal immunity during therapy and vaccination. The interaction between lung-derived signals and bone marrow cells during a respiratory virus infection has ..
  39. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..hepatica suggest a need to develop sustainable strategies, such as vaccination for the control of this disease...
  40. Microneedle-based immunization against pandemic influenza
    Mark R Prausnitz; Fiscal Year: 2011 medical personnel is extremely time consuming, as seen during the prolonged and inefficient annual influenza vaccination campaigns...
    Jay A Nelson; Fiscal Year: 2012
    ..mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and ..
  42. The development of probiotic yeast as an inexpensive vaccine delivery platform
    TRACEY JANE LAMB; Fiscal Year: 2013
    ..b>Vaccination is one of the most cost-effective health interventions that can protect people from infection in endemic areas, ..
  43. Vaccines for Sustainable Therapy of Opiate Addiction
    Frank M Orson; Fiscal Year: 2012
    ..An especially attractive alternative approach to help treat opiate addiction is vaccination against these drugs, which could become a powerful tool in assisting individuals to stop their abuse of these ..
  44. Development of a novel vaccine against congenital cytomegalovirus infection
    Christopher S Morello; Fiscal Year: 2010
    ..cells specific for an immunodominant antigen are ineffective at limiting viral replication, we speculated that vaccination using these antigens may at best elicit immunity that is not significantly greater than that generated during ..
  45. Mechanisms of Peripheral Induction of T-Cell Tolerance
    ..for promoting tolerance in autoimmune diseases or avoiding tolerance during protective or therapeutic vaccination. RELEVANCE: Each project uses autoimmune disease models to study the cellular and molecular mechanisms for ..
  46. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..Aim 3. Determine if vaccination with recombinant PsrP Basic Region protects against challenge...
  47. A. L. lactis-based vaccine for children with broad spectrum for enteric pathogens
    Wendy L Picking; Fiscal Year: 2013
    ..include: an outstanding safety profile, broad protection against multiple pathogens, ease of delivery (mucosal vaccination) and simple and inexpensive production...
  48. Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKL
    Ifor R Williams; Fiscal Year: 2012
    ..development of tolerance of antigens normally encountered in the gut lumen may be useful in developing oral vaccination strategies and in the treatment of human inflammatory bowel disease...
  49. Antibody cytokine fusion proteins against Cryptococcus neoformans
    DAVID OWEN BEENHOUWER; Fiscal Year: 2012
    ..neoformans infection with the goal of developing novel prophylactic and therapeutic vaccination strategies. For these fusion proteins, we will use an antibody specific for the outer capsule of C...
  50. The Role of CD1a in Protecting Against Human Tuberculosis
    Chetan Seshadri; Fiscal Year: 2013
    ..immediate goals are to study the role of lipid antigen presentation in the immunologic and clinical response to vaccination against tuberculosis...
  51. Biophysics of Drug Interactions with Viral Episomes
    James K Bashkin; Fiscal Year: 2013
    ..discovered, and which we study here, have the potential to save lives when used in conjunction with regular check-ups and vaccination, and have the potential to contribute significantly to the control and elimination of cervical cancer.
  52. Targeting the oral cavity epithelium for inducing mucosal immunity against HIV
    Harvinder Singh Gill; Fiscal Year: 2012
    ..We will engineer and develop a vaccination approach based on microscopic needles called microneedles (MNs) that can target vaccines in close proximity to ..
    Jay A Nelson; Fiscal Year: 2011
    ..mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and ..
  54. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..b>Vaccination is the most effective tool for preventing morbidity and mortality due to influenza...
  55. Crossprotective CTL Against Influenza
    Ellis L Reinherz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Current vaccination strategies against influenza A viruses are primarily based upon elicitation of neutralizing antibodies directed at virion surface expressed hemagglutinin (HA) and neuraminidase (..
  56. Causes of rotavirus vaccine failure in Zambian children
    Roma Chilengi; Fiscal Year: 2013
    ..of anti-rotavirus breast milk IgA and transplacental serum IgG) contributes to failed seroconversion following vaccination. (ii) Malnutrition negatively impacts infant immunity and increases the risk of post-vaccination rotavirus ..
  57. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..the incidence of microbial infection, testing the recall T cel and antibody responses to influenza virus vaccination after transplantation, as well as recall T cell responses to herpes zoster, herpes simplex, cytomegalovirus ..
  58. Role of innate immune responses in the activity of an Alphavirus based adjuvant.
    Robert E Johnston; Fiscal Year: 2013
    ..vaccine design by identification of pathways that can be targeted in order to achieve stronger immunity after vaccination. Our published and preliminary data indicate that VRP infect specific subsets of dendritic cells (DCs), ..
  59. Hepatitis C: Studies of Immunity and Pathogenesis
    Charles Rice; Fiscal Year: 2009 establish a database of conserved neutralization determinants that can be integrated into strategies for vaccination or passive immunotherapy...
  60. Role of liver fluke granulin in cholangiocarcinogenesis
    Jason P Mulvenna; Fiscal Year: 2013
    ..In addition, we propose to use gene silencing and vaccination of hamsters to determine whether Ov-GRN-1 is the major, or even sole, growth factor secreted by the parasite...
  61. Antigen presentation by epithelial stem cells to promote life long immunity
    ..Of the vaccine approaches tested in the SIV/macaque model, vaccination with live attenuated lentiviruses has consistently yielded the most effective and durable protection against ..
  62. Toward suicidal automation of porphyric Leishmania for photodynamic vaccination
    Kwang Poo Chang; Fiscal Year: 2010
    ..It is possible to increase the safety margin of live Leishmania for vaccination by molecular genetic approaches to attenuate their pathogenicity or to construct suicidal mutants...
  63. Anti-Idiotype Therapy of Human B Cell Malignancy
    Ronald Levy; Fiscal Year: 2007
    ..Animal models of B cell lymphoma will be used to develop more powerful methods of vaccination against the idiotype and to study the mechanisms of tumor immunity...
  64. Evaluation of vaccination reminder/recall systems for adolescent patients
    Peter Szilagyi; Fiscal Year: 2009
    ..and recall adolescents for needed immunizations, particularly among low-income adolescents who have lower vaccination rates and fewer preventive healthcare visits...
  65. Improving the efficacy of anti-nicotine immunotherapy
    Alexey G Mukhin; Fiscal Year: 2010 applicant): The long-term goal of this research project is to improve the efficacy of anti-nicotine vaccination/immunotherapy for smoking cessation...
  66. Decision-Making about Childhood HPV Vaccination among Low SES Mothers
    TIFFANY FLOYD; Fiscal Year: 2009
    ..Given the necessity of parental consent for the vaccination of minors, as well as the enhanced efficacy of the vaccine when delivered prior to the onset of the sexual ..
    Danuta Kozbor; Fiscal Year: 2001 explore the possibility of using poly(DL-lactide-co-glycolide) (PLG) microparticles as vehicles for oral vaccination with plasmid DNA encoding gp160 in combination with recombinant viral vectors expressing the env gene products ..
  68. Mechanisms of non-neutralizing antibody-mediated protection from influenza virus
    DENISE KAMINSKI; Fiscal Year: 2009
    ..S. per year. Humans can be protected by vaccination against seasonal influenza strains...
  69. Adjuvant-containing chimeric virus-like particles as improved influenza vaccines
    FU SHI contact QUAN; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): Although the influenza vaccine has been used for over 60 years, the current vaccination strategy against influenza A and B viruses is vulnerable to the unanticipated emergence of epidemic strains ..
  70. Minor Histocompatilibity Vaccination After Allo-Transpl*
    Koen Van Besien; Fiscal Year: 2004
    ..We hypothesize that post-transplant vaccination with HA1 or HA2 peptides in combination with GM-CSF in donor-recipient pairs that are HLA-identical, but ..
  71. Poxvirus adverse effects on cardiac cells and the heart
    Barbara Sherry; Fiscal Year: 2005
    ..bioterrorists may release smallpox virus in the United States, the government has implemented a multi-stage vaccination program...
  72. Risk Factors for Eczema Vaccinatum in Atopic Dermatitis
    Walter Holleran; Fiscal Year: 2009
    ..that smallpox virus might be employed as a bioterrorism agent has led to an early implementation of a limited vaccination program...
    Stanley R Riddell; Fiscal Year: 2010
    ..T cells is a hallmark of the host response to acute and persistent viral infections and a major objective of vaccination for infectious diseases and cancer...
  74. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..We have also found that: 1) antibody titers d Als3p (rAls3p-N). We have found that vaccination of mice with r a vaccine to prevent life threatening Candida i Furthermore, infections caused by strains and ..
  75. Evaluation of vaccination reminder/recall systems for adolescent patients
    Allison Kempe; Fiscal Year: 2009
    ..provided by applicant): Although patient reminder/recall systems have been shown to be effective at improving vaccination coverage levels for infants and younger children, little is known about the effectiveness of such systems for ..